OHARA Kenzo 大原賢三

… Alternative Names

Ohara Kenzo 大原賢三

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Researcher Number	20596308
Other IDs
Affiliation (Current)	2025: 旭川医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 旭川医科大学, 医学部, 講師 2018 – 2021: 旭川医科大学, 医学部, 助教 2017: 旭川医科大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related
Keywords	Principal Investigator Mal d 1 / Bet v 1 / PFAS / シラカバ花粉症 / 花粉食物アレルギー症候群 / 免疫療法 / 頭頸部外科 / 悪性腫瘍 / p53 Except Principal Investigator 鼻性NK/T細胞リンパ腫 … More / NK/T細胞リンパ腫 / 口蓋扁桃 / 口蓋扁桃摘出術 / IgA腎症 / 掌蹠膿疱症 / 扁桃病巣疾患 / ワクチン / ペプチド / 免疫療法 / 免疫抑制 / 腫瘍抗原 / EBウイルス / ペプチドワクチン / 免疫チェックポイント Less

花粉食物アレルギー症候群マウスモデルの作製と新規治療法の開発Principal Investigator
- Principal Investigator
  
  大原賢三
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
扁桃病巣疾患における基礎的、臨床的エビデンスの構築
- Principal Investigator
  
  高原幹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
Establishment of novel immunotherapy against nasal NK/T cell lymphoma
- Principal Investigator
  
  Harabuchi Yasuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
癌特異的翻訳後修飾を受けたビメンチンを標的とした頭頸部扁平上皮癌の免疫治療Principal Investigator
- Principal Investigator
  
  大原賢三
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
Developing novel immunotherapy against nasal NK/T cell lymphoma
- Principal Investigator
  
  Harabuchi Yasuaki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Asahikawa Medical College
Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinomaPrincipal Investigator
- Principal Investigator
  
  Ohara Kenzo
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Asahikawa Medical College

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma2024
- Author(s)
  Nagato T, Komatsuda H, Hayashi R, Takahara M, Ujiie N, Kosaka A, Ohkuri T, Oikawa K, Sato R, Wakisaka R, Kono M, Yamaki H, Ohara K, Kumai T, Kishibe K, Katada A, Hayashi T, Kobayashi H
- Journal Title
  
  Cancer Science
  
  Volume: 115 Issue: 4 Pages: 1073-1084
- DOI
  10.1111/cas.16079
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09599, KAKENHI-PROJECT-21H03082
[Journal Article] Expression of soluble CD27 in extranodal natural killer/T-cell lymphoma, nasal type: potential as a biomarker for diagnosis and CD27/CD70-targeted therapy2023
- Author(s)
  Nagato T, Komatsuda H, Hayashi R, Takahara M, Kishibe K, Yasuda S, Yajima Y, Kosaka A, Ohkuri T, Oikawa K, Harabuchi S, Kono M, Yamaki H, Wakisaka R, Hirata-Nozaki Y, Ohara K, Kumai T, Katada A, Hayashi T, Harabuchi Y, Kobayashi H
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: 72 Issue: 7 Pages: 2087-2098
- DOI
  10.1007/s00262-023-03394-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09599, KAKENHI-PROJECT-21H03082
[Journal Article] Mitogen‐activated protein kinase inhibition augments the T cell response against HOXB7‐expressing tumor through human leukocyte antigen upregulation2022
- Author(s)
  Komatsuda Hiroki、Wakisaka Risa、Kono Michihisa、Kumai Takumi、Hayashi Ryusuke、Yamaki Hidekiyo、Sato Ryosuke、Nagato Toshihiro、Ohkuri Takayuki、Kosaka Akemi、Ohara Kenzo、Takahara Miki、Katada Akihiro、Kobayashi Hiroya
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 2 Pages: 399-409
- DOI
  10.1111/cas.15619
- Data Source
  KAKENHI-PROJECT-21H03082, KAKENHI-PROJECT-20K09724
[Journal Article] Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery2021
- Author(s)
  Kono Michihisa、Kumai Takumi、Hayashi Ryusuke、Yamaki Hidekiyo、Komatsuda Hiroki、Wakisaka Risa、Nagato Toshihiro、Ohkuri Takayuki、Kosaka Akemi、Ohara Kenzo、Kishibe Kan、Takahara Miki、Katada Akihiro、Hayashi Tatsuya、Celis Esteban、Kobayashi Hiroya、Harabuchi Yasuaki
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: epub Issue: 12 Pages: 3421-3434
- DOI
  10.1007/s00262-021-02940-5
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] A critical role of STING-triggered tumor-migrating neutrophils for anti-tumor effect of intratumoral cGAMP treatment2021
- Author(s)
  Nagata Marino、Kosaka Akemi、Yajima Yuki、Yasuda Syunsuke、Ohara Mizuho、Ohara Kenzo、Harabuchi Shohei、Hayashi Ryusuke、Funakoshi Hiroshi、Ueda Jun、Kumai Takumi、Nagato Toshihiro、Oikawa Kensuke、Harabuchi Yasuaki、Esteban Celis、Ohkuri Takayuki、Kobayashi Hiroya
- Journal Title
  
  Cancer Immunology, Immunotherapy
  
  Volume: epub Issue: 8 Pages: 2301-2312
- DOI
  10.1007/s00262-021-02864-0
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02948, KAKENHI-PROJECT-19K06452
[Journal Article] Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma2020
- Author(s)
  Hayashi Ryusuke、Nagato Toshihiro、Kumai Takumi、Ohara Kenzo、Ohara Mizuho、Ohkuri Takayuki、Hirata-Nozaki Yui、Kosaka Akemi、Yasuda Syunsuke、Oikawa Kensuke、Kono Michihisa、Kishibe Kan、Takahara Miki、Katada Akihiro、Hayashi Tatsuya、Celis Esteban、Harabuchi Yasuaki、Kobayashi Hiroya et al
- Journal Title
  
  OncoImmunology
  
  Volume: 10 Issue: 1 Pages: 1856545-1856545
- DOI
  10.1080/2162402x.2020.1856545
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] Phosphorylated vimentin as an immunotherapeutic target against metastatic colorectal cancer.2019
- Author(s)
  Ohara M, Ohara K, Kumai T, Ohkuri T, Nagato T, Hirata-Nozaki Y, Kosaka A, Nagata M, Hayashi R, Harabuchi S, Yajima Y, Oikawa K, Harabuchi Y, Sumi Y, Furukawa H, Kobayashi H.
- Journal Title
  
  Cancer Immunol Immunother.
  
  Volume: ePub Issue: 6 Pages: 989-999
- DOI
  10.1007/s00262-020-02524-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02948, KAKENHI-PROJECT-19K07452
[Journal Article] PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma.2019
- Author(s)
  Hirata-Nozaki Y, Ohkuri T, Ohara K, Kumai T, Nagata M, Harabuchi S, Kosaka A, Nagato T, Ishibashi K, Oikawa K, Aoki N, Ohara M, Harabuchi Y, Uno Y, Takei H, Celis E, Kobayashi H.
- Journal Title
  
  J Transl Med.
  
  Volume: 17 Issue: 1
- DOI
  10.1186/s12967-019-1957-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] Intratumoral STING activations overcome negative impact of cisplatin on antitumor immunity by inflaming tumor microenvironment in squamous cell carcinoma.2019
- Author(s)
  Harabuchi S, Kosaka A, Yajima Y, Nagata M, Hayashi R, Kumai T, Ohara K, Nagato T, Oikawa K, Ohara M, Harabuchi Y, Ohkuri T, Kobayashi H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 522 Issue: 2 Pages: 408-414
- DOI
  10.1016/j.bbrc.2019.11.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02948, KAKENHI-PROJECT-19K18791
[Journal Article] Cyclin-dependent kinase 1 and survivin as potential therapeutic targets against nasal natural killer/T-cell lymphoma2019
- Author(s)
  Nagato Toshihiro、Ueda Seigo、Takahara Miki、Kishibe Kan、Komabayashi Yuki、Kumai Takumi、Ohara Kenzo、Hirata-Nozaki Yui、Harabuchi Shohei、Hayashi Ryusuke、Ohkuri Takayuki、Bernasconi Michele、Nadal David、Kobayashi Hiroya、Harabuchi Yasuaki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 5 Pages: 612-624
- DOI
  10.1038/s41374-018-0182-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02948
[Journal Article] Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma2018
- Author(s)
  Ohara Kenzo、Ohkuri Takayuki、Kumai Takumi、Nagato Toshihiro、Nozaki Yui、Ishibashi Kei、Kosaka Akemi、Nagata Marino、Harabuchi Shohei、Ohara Mizuho、Oikawa Kensuke、Aoki Naoko、Harabuchi Yasuaki、Celis Esteban、Kobayashi Hiroya
- Journal Title
  
  OncoImmunology
  
  Volume: 7 Issue: 9 Pages: e1466771-e1466771
- DOI
  10.1080/2162402x.2018.1466771
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20223, KAKENHI-PROJECT-17K16884
[Presentation] マウス扁平上皮癌モデルを用いた、化学療法とSTING活性化療法の併用に関する基礎研究2019
- Author(s)
  原渕翔平, 大栗敬幸, 小坂　朱, 永田真莉乃, 林　隆介, 大原賢三, 大原みずほ, 長門利純, 及川賢輔, 小林博也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] リン酸化抗原特異的T細胞を利用した悪性腫瘍に対するペプチドワクチン療法の基礎的解析2019
- Author(s)
  大原賢三, 熊井琢美, 長門利純, 林　隆介, 原渕翔平, 小林博也, 原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 癌特異的な翻訳後修飾を受けたp53タンパク質は特異的T細胞応答を惹起する2019
- Author(s)
  大原賢三, 大栗敬幸, 長門利純, 小林博也
- Organizer
  第23回日本がん免疫学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 頭頸部悪性腫瘍におけるCD74の発現2019
- Author(s)
  林　隆介, 長門利純, 永田真莉乃, 原渕翔平, 大原賢三, 大原みずほ, 小坂朱, 大栗敬幸, 及川賢輔, 小林博也
- Organizer
  第108回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] 鼻性NK/T細胞リンパ腫におけるCD27の発現2019
- Author(s)
  長門利純, 林　隆介, 原渕翔平, 野﨑　結, 大原賢三, 熊井琢美, 岸部　幹, 高原　幹, 小林博也, 原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] Cancer Immunity Cycleと化学療法2019
- Author(s)
  原渕翔平, 大原賢三, 野﨑　結, 熊井琢美, 長門利純, 林　達哉, 小林博也, 原渕保明
- Organizer
  第37回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] ストレス存在下に翻訳後修飾を受けた免疫原性を有するp53を標的としたヘルパーペプチドワクチン療法の解析2018
- Author(s)
  大原賢三//小林博也
- Organizer
  臨床ストレス応答学会
- Data Source
  KAKENHI-PROJECT-17K16884
[Presentation] リン酸化抗原を特異的に認識するT細胞の抗腫瘍効果の解析2018
- Author(s)
  大原賢三//大原みずほ//長門利純//大栗敬幸//小坂朱//林隆介//原渕翔平//永田真莉乃//及川賢輔//青木直子//小林博也
- Organizer
  北海道病理談話会
- Data Source
  KAKENHI-PROJECT-17K16884
[Presentation] 翻訳後修飾を受けたリン酸化p53を標的としたペプチドワクチン療法の検討2018
- Author(s)
  大原賢三//野﨑結//熊井琢美//長門利純//原渕翔平//小林博也//原渕保明
- Organizer
  日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K16884
[Presentation] 鼻性NK/T細胞リンパ腫におけるCDK1とサバイビンの発現2018
- Author(s)
  長門利純、大原賢三、原渕翔平、林隆介、大栗敬幸、永田真莉乃、大原みずほ、小坂朱、青木直子、及川賢輔、原渕保明、小林博也
- Organizer
  第51回北海道病理談話会
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] リン酸化抗原を標的としたヘルパーペプチドワクチン療法の基礎的解析2018
- Author(s)
  大原賢三//大原みずほ//長門利純//大栗敬幸//小坂朱//永田真莉乃//青木直子//及川賢輔//小林博也
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-17K16884
[Presentation] Expression of programmed death-ligand 1 in nasal natural killer/T-cell lymphoma2018
- Author(s)
  Nagato t, Ohkuri T, Ohara K, Nozaki Y, Kishibe K, Takahara M, Kumai T, Araki D, Komabayashi H, Kobayashi H, Harabuchi Y
- Organizer
  International Conference on EBV & KSHV 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02948
[Presentation] Targeting phosphorylated p53 to elicit tumor-reactive T helper responses agaist head and neck squamous cell carcinoma2018
- Author(s)
  Kenzo Ohara//Takumi Kumai//Toshihiro Nagato//Takayuki Ohkuri//Yui Nozaki//Mizuho Ohara//Nobuyuki Bandoh//Tatsuya Hayashi//Yasuaki Harabuchi//Hiroya Kobayashi
- Organizer
  American Association for Cancer Research Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16884
[Presentation] 翻訳後修飾を受けたリン酸化p53ペプチド特異的ヘルパーT細胞による抗腫瘍効果の解析2017
- Author(s)
  大原賢三, 平田　結, 長門利純, 熊井琢美, 大栗敬幸, 小坂　朱, 永田真莉乃, 青木直子, 及川賢輔, 小林博也
- Organizer
  第106回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-17K16884
[Presentation] Induction of tumor-reactive T helper-cell responses by phospho-peptide epitopes from tumor protein p532017
- Author(s)
  大原賢三, 野﨑　結, 熊井琢美, 長門利純, 原渕翔平, 永田真莉乃, 大栗敬幸, 小坂　朱, 及川賢輔, 青木直子, 原渕保明, 小林博也
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-17K16884
[Presentation] 翻訳後修飾を受けたリン酸化p53ペプチド特異的T細胞の抗腫瘍効果の解析2017
- Author(s)
  大原賢三, 平田　結, 長門利純, 熊井琢美, 小林博也, 原渕保明
- Organizer
  第35回日本耳鼻咽喉科免疫アレルギー学会
- Data Source
  KAKENHI-PROJECT-17K16884

1. 小林博也 (90280867)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
2. 熊井琢美 (00596306)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. 高原幹 (50322904)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. Harabuchi Yasuaki (80208686)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
5. 大栗敬幸 (70564061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
6. 長門利純 (80431419)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
7. 岸部幹 (80447101)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results

OHARA Kenzo 大原 賢三

Ohara Kenzo 大原 賢三

Research Projects

Research Products

Co-Researchers

花粉食物アレルギー症候群マウスモデルの作製と新規治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

扁桃病巣疾患における基礎的、臨床的エビデンスの構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of novel immunotherapy against nasal NK/T cell lymphoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

癌特異的翻訳後修飾を受けたビメンチンを標的とした頭頸部扁平上皮癌の免疫治療Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Developing novel immunotherapy against nasal NK/T cell lymphoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Soluble CD27 as a predictive biomarker for intra-tumoral CD70/CD27 interaction in nasopharyngeal carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of soluble CD27 in extranodal natural killer/T-cell lymphoma, nasal type: potential as a biomarker for diagnosis and CD27/CD70-targeted therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mitogen‐activated protein kinase inhibition augments the T cell response against HOXB7‐expressing tumor through human leukocyte antigen upregulation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A critical role of STING-triggered tumor-migrating neutrophils for anti-tumor effect of intratumoral cGAMP treatment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phosphorylated vimentin as an immunotherapeutic target against metastatic colorectal cancer.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PD-L1-specific helper T-cells exhibit effective antitumor responses: new strategy of cancer immunotherapy targeting PD-L1 in head and neck squamous cell carcinoma.2019

Author(s)

Journal Title

DOI

OHARA Kenzo 大原賢三

Ohara Kenzo 大原賢三