Horio Yoshiyuki 堀尾嘉幸

… Alternative Names

堀尾嘉幸ホリオヨシユキ

HORIO Yoshiyuki 堀尾嘉幸

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Researcher Number	30181530
Other IDs
External Links
Affiliation (Current)	2025: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2015 – 2022: 札幌医科大学, 医学部, 教授 2008 – 2013: 札幌医科大学, 医学部, 教授 1999 – 2004: Sapporo Medical University, Professor, 医学部, 教授 1997 – 1998: 大阪大学, 医学部, 助教授 1994 – 1996: Osaka University Faculty of Medicine, 医学部, 講師 … More 1995: 大阪大学, 医学部・, 講師 1991 – 1993: 大阪大学, 医学部, 助手 1986: Osaka University Medical School, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator General pharmacology / General pharmacology / Biological Sciences / Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / 応用薬理学・医療系薬学 Except Principal Investigator Circulatory organs internal medicine / Basic Section 47040:Pharmacology-related / Pathological medical chemistry / General medical chemistry … More / General pharmacology / Circulatory organs internal medicine / Basic Section 56010:Neurosurgery-related / General pharmacology / Nerve anatomy/Neuropathology / General physiology / Dermatology / 代謝生物化学 Less
Keywords	Principal Investigator カリウム / 脳 / CA3 / 網膜 / water channel / glia / 水チャネル / SIRT1 / 分化 / 内向き整流性カリウムチャネル … More / チャネル / synaptophysin / シナプス / ミュラー細胞 / ラミニン / グリア細胞 / 筋ジストロフィー / AQP4 / brain / ATP sensitive K^+ channel / K^+ channel / ATP感受性Kチャネル / Kチャネル / PDZドメイン / グリア / カリウムチャネル / sulfonylurea receptor / stomach / 壁細胞 / PC12 / 神経細胞 / NAD / 精巣 / 神経幹細胞 / 脱アセチル化酵素 / スルホニルウレア受容体 / ATP感受性カリウムチャネル / 海馬 / 黒質 / spatial buffering / クラスタリング / 内向き整流カリウムチャネル / 分子進化 / イントロン / Intronless遺伝子 / ゲノム遺伝子 / ヒスタミンH1受容体 / ヒスタミン / imaging / mdx mice / membrane repair / muscular dystrophy / 筋細胞 / 筋芽細胞 / 修復 / 筋力 / クレアチンキナーゼ / 運動 / 細胞膜修復 / 骨格筋 / ノックアウトマウス / 膜修復 / 細胞膜 / 福山型 / Becker型 / Duchenne型 / ROS / ミトコンドリア / 臨床研究 / 活性酸素 / マイトファジー / オートファジー / レスベラトロール / herbimycin / laminine / ポリリジン / マウス / 一次培養細胞 / モルモット / Kir4.1 / アストロサイト / 浮腫 / cDNA / チロシンリン酸化 / Parkinson disease / dopamine neuron / substantia nigra / テルチアピン / SUR / Parkinson病 / ドーパミン細胞 / スルフォニル尿素受容体(SUR) / gastric acid / cochlea / retina / channel / potassium / 胃酸 / バリウム / 胃 / 基底膜 / 蝸牛 / 色素上皮細胞 / patch clamp / chromosome / parietal cell / potassium channel / SAP97 / clustering / RT-PCR / パッチクランプ法 / 染色体地図 / パッチクランプ / Membrane protein / Chromosome / Evolution / Intronless gene / Intron / Gene / H1 receptor / Histamine / 膜蛋白質 / 染色体 / NGF / resveratrol / ユビキチン化 / p300 / メラノーマ / 神経堤 / deacetylase / Notch / PIP3 / メラノーマ細胞 / lamellipodia / neurite / 細胞移動 / 長寿遺伝子 / サーチュイン / 胎児 / ニコチンアミド / オリゴデンドロサイト / Sir2α / aldolase / helicase / subventricular zone / GFP / 上衣細胞 / 核局在シグナル / 老化 / ヒストン / ヌクレオチド / ATP / コンダクタンス / binding assay / 平滑筋 / ニコランジル / スルフォニル尿素受容体 / 相同組替え … More Except Principal Investigator クローニング / SIRT1 / G蛋白質 / ATP / ATP感受性カリウムチャネル / 心不全 / カリウムチャネル / マイトファジー / オートファジー / 膜2回貫通型カリウムチャネル / 内向き整流性カリウムチャネル / 中枢神経系 / クラスター / 中枢神経 / cloning / 培養細胞 / 心臓 / アフリカツメガエル卵母細胞 / パッチクランプ法 / 分子生物学 / 内向き整流カリウムチャネル / ヒスタミン / Jab1 / CSN-5 / G protein / inward rectifier / スルフォニルユレア受容体 / 内向き整流K^+チャネル / アンカリング蛋白 / ポリアミン / heart / G蛋白 / パッチクランプ / カリウム / スルフォニル尿素受容体 / 初代培養 / PET / 細胞死 / 酸化ストレス / グリア細胞 / ミトコンドリア / 筋ジストロフィー / clearance system / Glia / MRS / 認知障害 / 水頭症 / NAA / macromolecule / NPH / Glymphatic system / mTOR / リソソーム / オートファゴソーム / 前駆細胞 / 分化 / SIRTファミリー / 多発性硬化症 / マイクロRNA / 変性 / オリゴデンドロサイト / TISSUE DISTRIBUTION / FLUOROMETRY / HPLC / DOPAMINE / CONJUGATED DOPAMINE / DOPAMINE SULFATES / ヒト / イヌ / 生体内動態 / 代謝動態 / 生体内分布 / 蛍光分析 / 高速液体クロマトグラフィー / ドーパミン / ドーパミン硫酸抱合体 / β subunit / patch clamp / cardiomyocytes / L-type Ca2+ channel / カルシウムチャネル / βサブユニット / 心筋細胞 / L型カルシウムチャネル / tubulin / NG108-15 cells / Phosphorylation / GRK / microtubules / チュブリン / NG108-15細胞 / リン酸化反応 / G蛋白質共役型受容体キナーゼ / 細胞骨格微小管系 / sulfonylurea / K channel opener / ion channel / 血管平滑筋 / カリウムチャネル開口薬 / カリウムチャネル開口剤 / スルホニルウレア / 膵臓 / カリウムチャネルの開口剤 / neuron / substantia nigra / pituitary / hormone secretion / dopaminergic neuron / ion chanel / ラミニン / インスリン / ミュラー細胞 / 網膜 / G蛋白調整性カリウムチャネル / sulphonylurea receptor / iK1 channel / RT-PGR / ATP-sensitive inwardly rectifying K+ channels / inwardly rectifying K+ channels / iK1チャネル / RT-PCR / Hormone / Central Nervous System / Sulffonylurea receptor / Anchering protein / G-protein regulated K+channel / ATP sensitive K+channel / 2 membrane spanning K+channel / Inwardly rectifying K+channel / _CGMP / _CAMP / アンカリング蛋白質 / G蛋白質調節性K^+チャネル / ATP感受性K^+チャネル / 膜2回貫通型K^+チャネル / アクアポリン / ホルモン / スルホニルウレア受容体 / G蛋白調節性カリウムチャネル / cluster / polyamine / GTP-binding protein / synaps / knockout / brain / K^+ channels / シナプス / ノックアウト / culture cell / K^+ channel opener / sulfonylurea receptor / smooth muscle / ATP-sensitive potassium channels / NDP / K_<ATP>チャネル / cDNA / スルフォニルウレア / ATP感受性チャネル / チャネル / スルフオニル尿素受容体 / カリウムチャネルオープナ- / 平滑筋 / Southern blot / westem blot / 遺伝子配列 / 抗体 / 酵素定量 / ヒスタミンン / ジアミン酸化酵素 / S-アデノシルメチオニン / 遺伝子 / 不活性化 / メチル基転移酵素 / NMDA receptor / neurotoxin / microdialysis / upregulation / histamine H3 receptor / Histamine H1 receptor / 神経毒 / マイクロダイアリシス / NMDA受容体 / アップ・レギュレーション / ヒスタミンH3受容体 / ヒスタミンH1受容体 / [^3H]MEPYRAMINE BINDING ASSAY / DEBRISOQUINE / G PROTEIN-COUPLED RECEPTOR / CLONING / XENOPUS OOCYTE / HISTAMINE RECEPTOR / HISTAMINE / アフィニティラベル / 副腎髄質 / Ca^<++>動員受容体 / ロドプシンファミリ- / アフリカツメガエル / クロ-ニング / ヒスタミンH_1受容体 / デブリソキン水酸化酵素 / プロモーター領域 / [^3H]メピラミン / [^3H]メピラミン結合試験 / デブリソキン / G蛋白協調性受容体 / ヒスタミン受容体 / 界面活性剤 / レセプターバインディングアッセイ / カルシウム拮抗薬 / 電位依存性カルシウムチャンネル / 糖尿病 / B16F1メラノーマ細胞転移 / 悪性黒色腫 SIRT1 / 悪性黒色腫(メラノーマ) / lamellipodium / 転移 / 細胞移動 / B16F1メラノーマ細胞 / メラノーマ / 悪性黒色腫 / 色素細胞学 / 分子腫瘍学 / 細胞内局在 / ヒストン脱アセチル化酵素 / エピジェネティクス / 分子心臓病態学 / 点変異導入クローン / キメラクローン / トランスフェクション / HEK293細胞 / ATP依存性カリウムチャネル / サイクリックGMP / スライスパッチ / 内向き整流特性カリウム / in situ hybridization / 免疫組織化学 / 大腸菌での発現 / ヒスタミンNメチル基転移酵素 Less

Mechanisms of dysregulation of autophagy in heart failure
- Principal Investigator
  
  Kuno Atsushi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
Development of a novel therapeutics for muscular dystrophy by targeting mitophagy.
- Principal Investigator
  
  Hosoda Ryusuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Sapporo Medical University
Elucidation of membrane repair mechanismPrincipal Investigator
- Principal Investigator
  
  Horio Yoshiyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Sapporo Medical University
Elucidation of the function of the Glymphatic system in the human central nervous system
- Principal Investigator
  
  AKIYAMA YUKINORI
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Sapporo Medical University
Analysis of microRNA in oligodendrocyte degeneration
- Principal Investigator
  
  Hisahara Shin
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Sapporo Medical University
Novel role of SIRT1 in regulation of autophagy and its role in heart failure
- Principal Investigator
  
  Kuno Atsushi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
development of a new remedy for muscular dystrophiesPrincipal Investigator
- Principal Investigator
  
  Horio Yoshiyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Sapporo Medical University
Novel therapeutic approach for heart failure by promoting nuclear translocation of SIRT1, a protein deacetylase
- Principal Investigator
  
  TANNO Masaya
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
Functional roles of SIRT1 in the differentiation of neural cellsPrincipal Investigator
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
Development of novel melanoma therapy targeting SIRT1
- Principal Investigator
  
  YAMASITA Tosiharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Sapporo Medical University
Clarification of mechanisms to regulate the activity of protein deacetylase SIRT1 and its therapeutic application in heart failure
- Principal Investigator
  
  TANNO Masaya
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Sapporo Medical University
老化と体内時計Principal Investigator
- Principal Investigator
  
  堀尾嘉幸
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
Analysis of physiological function of calcium channel β subunit in heart muscle
- Principal Investigator
  
  TOHSE Noritsugu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Sapporo Medical University
脳Sirの老化、寿命における分子機能解析Principal Investigator
- Principal Investigator
  
  堀尾嘉幸
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Investigation for the roles of ions in the differentiation, structure and death in cellsPrincipal Investigator
- Principal Investigator
  
  HORIO Yoshiyuk
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
Mechanism of water transport; Elucidation of brain edema and development of treatment.Principal Investigator
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  2000 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  SAPPORO MEDICAL UNIVERSITY
The role of microtubules in the regulation of the signal transduction through the interaction with the G protein-coupled receptor kinase
- Principal Investigator
  
  HATTA Shinichi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Sapporo Medical University
ATP感受性カリウムチャネルの分子制御機構と生理作用Principal Investigator
- Principal Investigator
  
  堀尾嘉幸
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (B)
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
  Osaka University
Molecular dissection of inwardly rectifying KィイD1+ィエD1 channel, Kir4.1/KィイD2abィエD2-2, of glial cells.Principal Investigator
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General pharmacology
- Research Institution
  Sapporo Medical University
  Osaka University
カリウムイオン可視化によるカリウムチャネル機能評価とその応用Principal Investigator
- Principal Investigator
  
  堀尾嘉幸
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Its functional significance and molecular mechanism
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
Investigation of Molecular Diversity of ATP-Sensitive K^+ Channels.
- Principal Investigator
  
  INANOBE Atsushi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University Faculty of Medicine
Studies of inwardly rectifying K^+ channels and an approach to develop new methods for assaying K^+ channel activity.Principal Investigator
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
内向き整流特性カリウムチャネルの神経伝達調節と可塑性における役割
- Principal Investigator
  
  倉智嘉久
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Molecular Analysis of Inward Rectifier K^+channels in CNS
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Osaka University
Molecular Mechanism in Regulation of Inwardly Rectifying Potassium Channel and its Functional Disorder
- Principal Investigator
  
  KURACHI Yoshisa
- Project Period (FY)
  1995 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Molecular analysis of heart inwardly rectifying K+ channels
- Principal Investigator
  
  KURODA Masao
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
NOによる中枢神経細胞内向き整流カリウムチャネルの抑制性修飾とその分子機構
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
三量体G蛋白質による心筋細胞カリウムチャネル制御の分子機構
- Principal Investigator
  
  倉智嘉久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Intronless遺伝子の分子進化-ヒスタミンH1受容体を例として-Principal Investigator
- Principal Investigator
  
  堀尾嘉幸
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
心筋細胞ATP依存性カリウムチャネルの受容体および機械刺激依存性制御とその異常
- Principal Investigator
  
  倉智嘉久
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Molecular cloning of ATP-sensitive K^+ channels and development of the method evaluating K^+ channel openers.
- Principal Investigator
  
  KURACHI Yoshihisa
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Molecular Biology of Histamine H1 ReceptorPrincipal Investigator
- Principal Investigator
  
  HORIO Yoshiyuki
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Osaka University
New perspectives in research for histaminergic functions in CNS
- Principal Investigator
  
  WATANABE Takehiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tohoku University
ヒスタミンN-メチル基転移酵素活性変動に対する性ステロイドの効果
- Principal Investigator
  
  竹村基彦
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hyogo Medical University
ヒスタミンNメチル基転移酵素遺伝子の解析
- Principal Investigator
  
  KURODA Masao
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Osaka University
CLONING OF HISTAMINE H1-RECEPTOR cDNA
- Principal Investigator
  
  FUKUI Hiroyuki
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  OSAKA UNIVERSITY
電位依存性カルシウムチャンネルの分子レベルでの研究
- Principal Investigator
  
  FUKUI Hiroyuki
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Osaka University
An HPLC method for determination of dopamine, dopamine-3-O- and dopamine-4-O-sulfate in plasma, urine and tissues.
- Principal Investigator
  
  YAMATODANI Atsushi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University

[Book] 「レスベラトロールによる筋ジストロフィー治療の試み」レスベラトロールの基礎と応用(坪田一男監修)2012
- Author(s)
  久野篤史、堀尾嘉幸
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22590245
[Book] 「トランスレスベラトロールの機能性解明」機能性食品・素材と運動療法(大澤俊彦他監修)2012
- Author(s)
  濱田博喜、堀尾嘉幸
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Resveratrol, a SIRT1 activator, attenuates aging-associated alterations in skeletal muscle and heart in mice.2023
- Author(s)
  Hosoda Ryusuke, Nakashima Ryuta, Yano Masaki, Iwahara Naotoshi, Asakura Seidai, Nojima Iyori, Saga Yukika, Kunimoto Risa, Horio Yoshiyuki, Kuno Atsushi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 152 Issue: 2 Pages: 112-122
- DOI
  10.1016/j.jphs.2023.04.001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06632, KAKENHI-PROJECT-20K07068
[Journal Article] SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX2022
- Author(s)
  Kuno Atsushi、Hosoda Ryusuke、Tsukamoto Miki、Sato Tatsuya、Sakuragi Hiromi、Ajima Nami、Saga Yukika、Tada Kouhei、Taniguchi Yoshiki、Iwahara Naotoshi、Horio Yoshiyuki
- Journal Title
  
  Cardiovascular Research
  
  Volume: 118 Issue: 17 Pages: 3360-3373
- DOI
  10.1093/cvr/cvac026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07068, KAKENHI-PROJECT-21K15629
[Journal Article] Downregulation of IGFBP5 contributes to replicative senescence via ERK2 activation in mouse embryonic fibroblasts2022
- Author(s)
  Iyori Nojima, Ryusuke Hosoda, Yuki Toda, Yoshiki Saito, Naohiro Ueda, Kouhei Horimoto, Naotoshi Iwahara, Yoshiyuki Horio, Atsushi Kuno
- Journal Title
  
  Aging
  
  Volume: 14 Issue: 7 Pages: 2966-2988
- DOI
  10.18632/aging.203999
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17806, KAKENHI-PROJECT-20K07068
[Journal Article] Cellular effects of resveratrol in health and disease2021
- Author(s)
  久野篤史、堀尾嘉幸
- Journal Title
  
  生化学
  
  Volume: 93 Issue: 1 Pages: 100-108
- DOI
  10.14952/SEIKAGAKU.2021.930100
- ISSN
  0037-1017
- Year and Date
  2021-02-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-20K07068
[Journal Article] Resveratrol improves motor function in patients with muscular dystrophies: an open-label, single-arm, phase IIa study2020
- Author(s)
  Kawamura Kentaro、Fukumura Shinobu、Nikaido Koki、Tachi Nobutada、Kozuka Naoki、Seino Tsugumi、Hatakeyama Kingya、Mori Mitsuru、Ito Yoichi M.、Takami Akiyoshi、Hinotsu Shiro、Kuno Atsushi、Kawasaki Yukihiko、Horio Yoshiyuki、Tsutsumi Hiroyuki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41598-020-77197-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08343, KAKENHI-PROJECT-18K06965
[Journal Article] Different Antioxidative and Antiapoptotic Effects of Piceatannol and Resveratrol2020
- Author(s)
  Hosoda Ryusuke、Hamada Hiroki、Uesugi Daisuke、Iwahara Naotoshi、Nojima Iyori、Horio Yoshiyuki、Kuno Atsushi
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 376 Issue: 3 Pages: 385-396
- DOI
  10.1124/jpet.120.000096
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07102
[Journal Article] SIRT1 deficiency interferes with membrane resealing after cell membrane injury2019
- Author(s)
  Fujiwara Daisuke、Iwahara Naotoshi、Sebori Rio、Hosoda Ryusuke、Shimohama Shun、Kuno Atsushi、Horio Yoshiyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 6 Pages: e0218329-e0218329
- DOI
  10.1371/journal.pone.0218329
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06965, KAKENHI-PROJECT-19K07102, KAKENHI-PROJECT-16H06280
[Journal Article] Resveratrol Ameliorates Mitophagy Disturbance and Improves Cardiac Pathophysiology of Dystrophin-deficient mdx Mice.2018
- Author(s)
  Kuno A, Hosoda R, Sebori R, Hayashi T, Sakuragi H, Tanabe M, Horio Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 8 Issue: 1 Pages: 15555-15555
- DOI
  10.1038/s41598-018-33930-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
[Journal Article] Resveratrol Decreases Oxidative Stress by Restoring Mitophagy and Improves the Pathophysiology of Dystrophin-Deficient mdx Mice.2018
- Author(s)
  Sebori R, Kuno A, Hosoda R, Hayashi T, Horio Y.
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: 2018 Issue: 1 Pages: 9179270-9179270
- DOI
  10.1155/2018/9179270
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08600, KAKENHI-PROJECT-17K15582
[Journal Article] 筋ジストロフィーの新治療法の開発2017
- Author(s)
  久野篤史、細田隆介、堀尾嘉幸
- Journal Title
  
  メディカル・サイエンス・ダイジェスト
  
  Volume: 42 Pages: 38-42
- Data Source
  KAKENHI-PROJECT-15K08312
[Journal Article] 筋ジストロフィーの新治療法の開発2016
- Author(s)
  久野篤史、細田隆介、堀尾嘉幸
- Journal Title
  
  Medical Science Digest
  
  Volume: 42 Pages: 642-646
- Data Source
  KAKENHI-PROJECT-15K08312
[Journal Article] Biochemical effects of the flavanol-rich lychee fruit extract on the melanin biosynthesis and reactive oxygen species.2016
- Author(s)
  Hagiwara K, Okura M, Sumikawa Y, Hida T, Kuno A, Horio Y, Yamashita T.
- Journal Title
  
  J Dermatol.
  
  Volume: 未定 Issue: 10 Pages: 1174-1183
- DOI
  10.1111/1346-8138.13326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08312, KAKENHI-PROJECT-25461705
[Journal Article] 長寿遺伝子サーチュイン2016
- Author(s)
  堀尾嘉幸、國本梨沙、久野篤史
- Journal Title
  
  THE LUNG perspectives
  
  Volume: 24 Pages: 303-306
- Data Source
  KAKENHI-PROJECT-15K08312
[Journal Article] SIRT1: A Novel Target for the Treatment of Muscular Dystrophies.2016
- Author(s)
  Kuno A, Horio Y.
- Journal Title
  
  Oxid Med Cell Longev.
  
  Volume: 未定 Issue: 1 Pages: 6714686-6714686
- DOI
  10.1155/2016/6714686
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08312
[Journal Article] The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy.2015
- Author(s)
  Kuno A, Tanno M, Horio Y.
- Journal Title
  
  Ann N Y Acad Sci.
  
  Volume: 1348 Issue: 1 Pages: 46-54
- DOI
  10.1111/nyas.12812
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08312
[Journal Article] Sirt1-deficient mice have hypogonadotropic hypogonadism due to defective GnRH neuronal migration.2015
- Author(s)
  Di Sante G, Wang L, Wang C, Jiao X, Casimiro MC, Chen K, Pestell TG, Yaman I, Di Rocco A, Sun X, Horio Y, Powell MJ, He X, McBurney MW, Pestell RG.
- Journal Title
  
  Mol Endocrinol
  
  Volume: ２９ Issue: 1 Pages: 200-212
- DOI
  10.1007/s11060-014-1686-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08312, KAKENHI-PROJECT-15K18992
[Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 Protein-mediated modulation of p300 Protein.2013
- Author(s)
  Kuno A et al.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 8 Pages: 5963-5972
- DOI
  10.1074/jbc.m112.392050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis2013
- Author(s)
  Srisuttee R, Koh SS, Malilas W, Moon J, Cho IR, Jhun BH, Horio Y, Chung YH
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 429 Pages: 45-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Differential cell-protective function of two resveratrol (trans-3,5,4'-trihydroxystilbene) glucosides against oxidative stress2013
- Author(s)
  Hosoda R, Kuno A, Hori YS, Ohtani K, Wakamiya N, Oohori A, Hamada H, Horio Y
- Journal Title
  
  J. Pharmacol. Exp. Ther
  
  Volume: 344 Pages: 124-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 Protein-mediated modulation of p300 Protein2013
- Author(s)
  Kuno A, Hori YS, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
- Journal Title
  
  J. Biol. Chem
  
  Volume: 288 Pages: 5963-5972
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of -catenin2012
- Author(s)
  Cho IR, Koh SS, Malilas W, Srisuttee R, Moon J, Choi YW, Horio Y, Oh S, Chung YH
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 423 Pages: 270-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Emerging beneficial roles of sirtuins in heart failure.2012
- Author(s)
  Tanno M et al.
- Journal Title
  
  Basic Res Cardiol.
  
  Volume: 107 Issue: 4 Pages: 273-273
- DOI
  10.1007/s00395-012-0273-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085, KAKENHI-PROJECT-23591086
[Journal Article] Hepatitis B virus X(HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase2012
- Author(s)
  Srisuttee R, Koh SS, Kim SJ, Malilas W, Boonying W, Cho IR, Jhun BH, Ito M, Horio Y,Seto E, Oh S, Chung YH
- Journal Title
  
  Oncol Rep
  
  Volume: 28 Pages: 276-282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Emerging beneficial roles of sirtuins in heart failure2012
- Author(s)
  Tanno M, Kuno A, Horio Y, Miura T
- Journal Title
  
  Basic Res Cardiol
  
  Volume: 107 Pages: 273-275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] レスベラトロールの筋肉・神経疾患への応用2012
- Author(s)
  堀尾嘉幸、久野篤史
- Journal Title
  
  Anti-aging Medicine (アンチ・エイジング医学)
  
  Volume: Vol 8 Pages: 906-912
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse2011
- Author(s)
  Hori SY, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K and Horio Y
- Journal Title
  
  a model for Duchenne muscular dystrophy. J Pharmacol Exp Ther 338
  
  Pages: 784-794
- Data Source
  KAKENHI-PROJECT-22591228
[Journal Article] Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori SY, et al
- Journal Title
  
  J.Pharmacol.Exp.Ther.
  
  Volume: 338 Issue: 3 Pages: 784-794
- DOI
  10.1124/jpet.111.183210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245, KAKENHI-PROJECT-23591085
[Journal Article] Diabetes : Insulin signal meets SIRT1 at AKT2011
- Author(s)
  Y.Horio
- Journal Title
  
  Nat Rev Endocrinol
  
  Volume: 8 Issue: 3 Pages: 131-132
- DOI
  10.1038/nrendo.2011.208
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Cellular and molecular effects of sirtuins in health and disease2011
- Author(s)
  Horio Y, Hayashi T, Kuno A, Kunimoto R
- Journal Title
  
  Clin Sci
  
  Volume: 121 Issue: 5 Pages: 191-203
- DOI
  10.1042/cs20100587
- Data Source
  KAKENHI-PROJECT-22591228
[Journal Article] Cellular and molecular effects of sirtuins in health and disease2011
- Author(s)
  Horio Y, Hayashi T, Kuno A, Kunimoto R
- Journal Title
  
  Clin Sci
  
  Volume: 121 Pages: 191-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Longevity-relevant regulation of autophagy at the level of the acetylproteome2011
- Author(s)
  Marino G, Morselli E, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Benit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, Lopez-Otin C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G
- Journal Title
  
  Autophagy
  
  Volume: 7 Pages: 647-649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Resveratrol ameliorates muscular pathology in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori SY , Kuno A, Hosoda R, Tanno M, MiuraT, Shimamoto K and Horio Y
- Journal Title
  
  J. Pharmacol. Exp. Ther
  
  Volume: 338 Pages: 784-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Cellular and molecular effects of sirtuins in health and disease2011
- Author(s)
  Horio Y, et al
- Journal Title
  
  Clin.Sci.
  
  Volume: 121 Pages: 191-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Diabetes: Insulin signal meets SIRT1 at AKT2011
- Author(s)
  Horio Y
- Journal Title
  
  Nat Rev Endocrinol
  
  Volume: 8 Pages: 131-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Cellular and molecular effects of sirtuins in health and disease.2011
- Author(s)
  Horio Y, Hayashi T, Kuno A, Kunimoto R.
- Journal Title
  
  Clin.Sci.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome2011
- Author(s)
  Morselli E, Marino G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Benit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, Lopez-Otin C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G
- Journal Title
  
  J. Cell Biol
  
  Volume: 192 Pages: 615-629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growthfactor-induced neurite outgrowth in PC12 cells2010
- Author(s)
  Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y
- Journal Title
  
  FEBS Lett
  
  Volume: 584 Pages: 2821-2826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure2010
- Author(s)
  Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y
- Journal Title
  
  J Biol Chem 285
  
  Volume: 285 Issue: 11 Pages: 8375-8382
- DOI
  10.1074/jbc.m109.090266
- Data Source
  KAKENHI-PROJECT-22591228
[Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells.2010
- Author(s)
  Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y.
- Journal Title
  
  FEBS Lett.
  
  Volume: 584 Pages: 2821-2826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590245
[Journal Article] Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure2010
- Author(s)
  Tanno M, Kuno A, Yano T, Miura T, Hisahara S, Ishikawa S, Shimamoto K, Horio Y.
- Journal Title
  
  J Biol Chem 285
  
  Pages: 8375-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590869
[Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells2010
- Author(s)
  Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y
- Journal Title
  
  FEBS Lett 584
  
  Volume: 584 Issue: 13 Pages: 2821-2826
- DOI
  10.1016/j.febslet.2010.04.063
- Data Source
  KAKENHI-PROJECT-22591228
[Journal Article] Protein deacetylase SIRT1 in the cytoplasm promotes nerve growth factor-induced neurite outgrowth in PC12 cells2010
- Author(s)
  Sugino T, Maruyama M, Tanno M, Kuno A, Houkin K, Horio Y.
- Journal Title
  
  FEBS Lett 584
  
  Pages: 2821-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590869
[Journal Article] Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation2008
- Author(s)
  Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Horio Y.
- Journal Title
  
  Proc Natl Acad Sci U S A 105
  
  Pages: 15599-15604
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590869
[Journal Article] NAD dependent histone deacetylase SIRT12005
- Author(s)
  Hisahara S, Chiba S, Matsumoto H, Horio Y
- Journal Title
  
  J.Pharmacol.Sci. in press
- Data Source
  KAKENHI-PROJECT-15659062
[Journal Article] Predominant expression of Sir2a, an NAD-dependent histone deacetylase in the mouse embryonic heart and brain.2004
- Author(s)
  Sakamoto J, Miura T, Shimamoto K, Horio Y
- Journal Title
  
  FEBS Lett. 556
  
  Pages: 281-286
- Data Source
  KAKENHI-PROJECT-15659062
[Journal Article] Sir2の分子機能解析2003
- Author(s)
  堀尾嘉幸, 久原真, 坂本淳
- Journal Title
  
  日薬理誌 122
  
  Pages: 30-32
- NAID
  10018622274
- Data Source
  KAKENHI-PROJECT-15659062
[Patent] 筋ジストロフィーを処置するための組成物2011
- Inventor(s)
  堀尾嘉幸、堀佑輔、久野篤史
- Industrial Property Rights Holder
  堀尾嘉幸、堀佑輔、久野篤史
- Filing Date
  2011-09-13
- Overseas
- Data Source
  KAKENHI-PROJECT-22590245
[Patent] 筋ジストロフィーを処置するための組2011
- Inventor(s)
  堀尾嘉幸、久野篤史、堀佑輔権
- Industrial Property Rights Holder
  札幌医科大学
- Filing Date
  2011-09-14
- Data Source
  KAKENHI-PROJECT-22590245
[Patent] レスベラトロールを含む剤、及び組成物2011
- Inventor(s)
  堀尾嘉幸、濱田博喜、清水芳雄
- Industrial Property Rights Holder
  堀尾嘉幸、濱田博喜、清水芳雄
- Industrial Property Number
  2011-111971
- Filing Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22590245
[Patent] レスベラトロールを含む剤、及び組成2011
- Inventor(s)
  濱田博喜、堀尾嘉幸、清水芳雄
- Industrial Property Rights Holder
  備前化成株式会社
- Industrial Property Number
  2011-111971
- Filing Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22590245
[Patent] 筋ジストロフィーを処置するための組成物2010
- Inventor(s)
  堀尾嘉幸、堀佑輔、久野篤史
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Number
  2010-205453
- Filing Date
  2010-09-14
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロールはオートTreatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.ファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2022
- Author(s)
  Ryusuke Hosoda, Atsushi Kuno, Ryuta Nakashima, Seidai Asakura, Naotoshi Iwahara, Iyori Nojima, Risa Kunimoto, Yoshiyuki Horio.
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] レスベラトロールはオートファジーを活性化して加齢による筋委縮と運動機能低下を軽減する2021
- Author(s)
  細田隆介、久野篤史、中島龍汰、朝倉聖大、岩原直敏、野島伊世里、國本梨沙、堀尾嘉幸
- Organizer
  第72回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] レスベラトロールは加齢による筋委縮と筋機能障害を軽減する2021
- Author(s)
  細田隆介, 久野篤史, 朝倉聖大, 岩原直敏, 野島伊世里, 國本梨沙, 堀尾嘉幸
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07068
[Presentation] レスベラトロールは加齢による筋委縮を抑制し運動機能を維持する2021
- Author(s)
  Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
- Organizer
  第43回分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] Treatment with resveratrol attenuates aging-related loss of muscle mass and function in mice.2021
- Author(s)
  Hosoda R, Kuno A, Asakura S, Iwahara N, Nojima I, Kunimoto R, Horio Y.
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] 植物由来ポリフェノールであるピセアタンノールとレスベラトロールのSIRT1活性化を介した細胞保護作用の比較2020
- Author(s)
  細田隆介久野篤史濱田博喜堀尾嘉幸
- Organizer
  第71回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] The histone deacetylase SIRT1 mediates the proper DNA repair response by targeting histone H2AX to protect against doxorubicin-induced cardiotoxicity.2020
- Author(s)
  Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Horio
- Organizer
  ESC Congress 2020
- Data Source
  KAKENHI-PROJECT-20K07068
[Presentation] Deletion of SIRT1 in the skeletal muscle decreases type IIa oxidative muscle fiber in mice.2020
- Author(s)
  Hosoda R, Kuno A, Asakura S, Horio Y.
- Organizer
  Experimental Biology 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] マイトファジー活性を標的とした筋ジストロフィーの新規治療法開発2019
- Author(s)
  細田隆介、久野篤史、堀尾嘉幸
- Organizer
  第70回薬理学会北部会
- Data Source
  KAKENHI-PROJECT-19K07102
[Presentation] レスベラトロールの生体作用とその標的としてのタンパク質脱アセチル化酵素SIRT12019
- Author(s)
  堀尾嘉幸
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-18K06965
[Presentation] Role of impaired autophagosome clearance in cardomyopathy of dystrophin-deficient mice.2018
- Author(s)
  久野篤史、細田隆介、堀尾嘉幸
- Organizer
  第82回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] Restoration of impaired autophagosome clearance underlies amelioration of cardiomyopathy afforded by SIRT1 activation in dystrophin-deficient mice.2017
- Author(s)
  Kuno A, Hosoda R, Horio Y.
- Organizer
  Cardiovascular and Metabolic Week 2017 (CVMW2017)
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] 筋ジストロフィー心筋におけるオートファジー不全の意義2017
- Author(s)
  久野篤史、細田隆介、瀬堀理生、堀尾嘉幸
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] タンパク質脱アセチル化酵素SIRT1の分子機能とその筋ジストロフィーへの応用2017
- Author(s)
  堀尾嘉幸
- Organizer
  第69回北日本小児科学会
- Invited
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] SIRT1はドキソルビシン誘導性心筋障害を悪化させる2017
- Author(s)
  細田隆介、久野篤史、塚本美樹、堀尾嘉幸
- Organizer
  日本薬理学会
- Place of Presentation
  長崎新聞文化ホール（長崎県長崎市）
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] SIRT1は筋機能維持と筋障害軽減に働く2017
- Author(s)
  瀬堀理生、久野篤史、細田隆介、堀尾嘉幸
- Organizer
  第42回　日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] Role of impaired autophagy caused by aberrant activation of mTORC1 in dystrophic cardiomyopathy.2017
- Author(s)
  Kuno A, Hosoda R, Horio Y
- Organizer
  Keystone Symposia Conference: Aging and Mechanisms of Aging-Related Disease
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] 筋ジストロフィー心筋におけるオートファジー不全の意義2017
- Author(s)
  久野篤史、細田隆介、瀬堀理生、堀尾嘉幸
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-17K08600
[Presentation] レスベラトロールによる筋ジストロフィー改善におけるミトコンドリアオートファジーの役割2017
- Author(s)
  瀬堀理生、久野篤史、細田隆介、堀尾嘉幸
- Organizer
  第68回日本薬理学会北部会
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] 筋ジストロフィーに対するレスベラトロールの探索的臨床研究2015
- Author(s)
  堀尾嘉幸、川村健太郎、福村忍、二階堂弘輝、舘延忠、畠山欣也、久原真、下濱俊、小塚直樹、林貴士、久野篤史、堤裕幸
- Organizer
  第６６回薬理学会北部会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-18
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] SIRT1の筋保護作用とその応用2015
- Author(s)
  堀尾嘉幸、久野篤史、林貴士、國本梨沙、細田隆介、瀬堀理生、塚本美樹、川村健太郎、福村忍、二階堂弘輝、舘延忠、畠山欣也、久原真、下濱俊、小塚直樹、堤裕幸
- Organizer
  第１７回薬物活性シンポジウム
- Place of Presentation
  新潟大学医学部有壬記念館
- Year and Date
  2015-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-15K08312
[Presentation] Role of SIRT3, a Mitochondrial Protein Deacetylase, in Type 2 Diabetic Myocardium2013
- Author(s)
  Kuno A, Itoh T, Sato T, Kouzu H, Tanno M, Miki T, Horio Y, Miura T
- Organizer
  第77回日本循環器学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2013-03-17
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] Function of SIRT1 in health and disease2012
- Author(s)
  堀尾嘉幸
- Organizer
  International Symposium of　Asian Association of Aging Research　2012
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Function of SIRT1 in health and Desease2012
- Author(s)
  Horio Y
- Organizer
  International Symposium of Asian Association of Aging Research 2012 in Fukuoka
- Place of Presentation
  Fukuoka
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] FOXOtranscription factors play a crucial role in the anti-cell death effects of SIRT1 under oxidative stress2012
- Author(s)
  Hori YS, Kuno A, Hosoda R, Horio Y
- Organizer
  Keystone Symposia "Aging and Diseases of Aging"
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] 酸化ストレスに対する蛋白質脱アセチル化酵素SIRT3の神経保護作用2012
- Author(s)
  堀尾嘉幸ら
- Organizer
  神経科学学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1 drives melanoma cell migration by modulating phosphatidyl inositol trisphosphate at the leading edge2012
- Author(s)
  Kunimoto R, Jimbow K, Tanimura A, Sato M, Hisahara S, Sugino T, Hirobe T, Yamashita T, Horio Y
- Organizer
  Keystone Symposia "Aging and Diseases of Aging"
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Resveratrol, a SIRT1 activator, prevents cardiomyopathy in dystrophin-deficient mice by down-regulation of p3002012
- Author(s)
  Kuno A, Tanno M, Miki T, Ishikawa S, Horio Y, Miura T.
- Organizer
  European Society of Cardiology Congress 2012
- Place of Presentation
  Munich
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] SIRT1 inhibits cardiomyocyte hypertrophy via negative regulation of p3002012
- Author(s)
  Kuno A & Horio Y
- Organizer
  Keystone Symposia "Aging and Diseases of Aging"
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] a SIRT1 activator, prevents cardiomyopathy in dystrophin-deficient mice by down- regulation of p3002012
- Author(s)
  Kuno A, Tanno M, Miki T, Ishikawa S, Horio Y, Miura T
- Organizer
  European Society of Cardiology Congress 2012
- Place of Presentation
  Munich, Germany
- Year and Date
  2012-08-26
- Data Source
  KAKENHI-PROJECT-23591085
[Presentation] A neuroprotective effect of protein deacetylase SIRT3 against oxidative stress2012
- Author(s)
  Horio Y, Hayashi T
- Organizer
  Nuroscience 2012
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1活性化剤レスベラトロールはmdxマウスの筋線維化を抑制する2011
- Author(s)
  堀佑輔、久野篤史、細田隆介、堀尾嘉幸
- Organizer
  第84回日本薬理学会
- Place of Presentation
  (横浜)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Sirt1活性化剤レスベラトロールはdystrophin欠損による心筋障害を軽減する2011
- Author(s)
  久野篤史、堀佑輔、細田隆介、三浦哲嗣、堀尾嘉幸
- Organizer
  第84回日本薬理学会
- Place of Presentation
  (横浜)
- Year and Date
  2011-03-23
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Resveratrol ameliorates muscle pathogenesis in mdx mouse2011
- Author(s)
  Yusuke S. Hori Y, Hayashi T, Kuno A, Hosoda R, Horio Y
- Organizer
  a model for Duchenne muscular dystrophy. Society for Neurosci. Washington DC
- Data Source
  KAKENHI-PROJECT-22591228
[Presentation] レスベラトロールとレスベラトロール配糖体の抗酸化作用と細胞死抑制機能の比較2011
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  第84回日本薬理学会
- Place of Presentation
  (横浜)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Resveratrol ameliorates muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori YS, Hayashi T, Kuno A, Hosoda R, Horio Y
- Organizer
  neuroscience Meeting
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Resveratrol ameliorates dystrophic muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy2011
- Author(s)
  Hori YS, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
- Organizer
  Gordon Research Conference Muscle Myogenesis:New Horizons for Myogenesis
- Place of Presentation
  WaterVille Valley, USA
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Resveratrol ameliorates dystrophic muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy. Gordon Research Coference Muscle Myogenesis2011
- Author(s)
  Hori Y, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
- Organizer
  New Horizons for Myogenesis
- Place of Presentation
  Waterville Valley Resort, Waterville Valley, NH, USA
- Data Source
  KAKENHI-PROJECT-22591228
[Presentation] 神経細胞でのNAD+依存性ヒストン脱アセチル化酵素SIRT3の酸化ストレスによる核への局在2011
- Author(s)
  林貴士、下濱俊、堀尾嘉幸
- Organizer
  第84回日本薬理学会
- Place of Presentation
  (横浜)
- Year and Date
  2011-03-22
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Activation of Sirt1 suppresses hypertrophic response of cardiomyocytes by inhibition of H3K9 acetylation via p roteasome-mediated p300 degradation.2010
- Author(s)
  Kuno A, Tanno M, Ishikawa S, Horio Y, Miura T.
- Organizer
  83^<rd> Scientific Session of American Heart Association
- Place of Presentation
  Chicago,U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] 蛋白脱アセチル化酵素Sirt1による心肥大抑制におけるp300発現制御の役割2010
- Author(s)
  久野篤史、三浦哲嗣、島本和明、堀尾嘉幸
- Organizer
  第61回日本薬理学会北部会
- Place of Presentation
  札幌
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] PC12細胞で細胞質中のSIRT1はNGF誘発性神経突起を伸長させる2010
- Author(s)
  杉野寿哉、堀尾嘉幸
- Organizer
  Neuro2010
- Place of Presentation
  神戸
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロールとレスベラトロール配糖体の薬理作用の比較2010
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  第24回北海道薬物作用談話会
- Place of Presentation
  札幌
- Year and Date
  2010-07-24
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロール配糖体の酸化ストレス抑制作用2010
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  第61回日本薬理学会北部会
- Place of Presentation
  札幌
- Year and Date
  2010-09-10
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Activation of Sirt1 suppresses hypertrophic response of cardiomyocytes by inhibition of H3K9 acetylation via proteasome-mediated p300 degradation2010
- Author(s)
  Kuno A, Tanno M, Ishikawa S, Miura T, Horio Y
- Organizer
  AHA2010
- Place of Presentation
  Chicago
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] レスベラトロール配糖体の酸化ストレス誘導性細胞死に対する抑制作用2010
- Author(s)
  細田隆介、堀佑輔、久野篤史、濱田博喜、堀尾嘉幸
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] SIRT1 inhibits oxidative stress-induced cell death by suppression of p53 and the ind MnSOD through FOXO transcription factor.2010
- Author(s)
  Hori Y, Kuno A, Hosoda R, Horio Y
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Inhibition of protein deacetylase SIRT1 suppresses in vitro and in vivo invasionof melanoma cells2010
- Author(s)
  Kunimoto R, Jimbow K, Yamashita T, Okura M, Hirobe T, Sato M, Hisahara S, Horio Y
- Organizer
  The 40thAnnual Meeting of the European Society for Deramatolo- gical Resarch (ESDR)
- Place of Presentation
  Helsinki, Finland
- Data Source
  KAKENHI-PROJECT-22591228
[Presentation] レスベラトロールによる筋ジストロフィーの治療2010
- Author(s)
  堀佑輔、久野篤史、細田隆介、丹野雅也、堀尾嘉幸
- Organizer
  薬物活性シンポジウム
- Place of Presentation
  札幌
- Year and Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] 蛋白質脱アセチル化酵素SIRT1の研究2010
- Author(s)
  堀尾嘉幸
- Organizer
  蛋白研セミナー
- Place of Presentation
  大阪
- Year and Date
  2010-11-25
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Sirt1 promotes p300 deacetylation and its degradation via the proteasome pathway.2010
- Author(s)
  Kuno A, Miura T, Shimamoto K, Horio Y
- Organizer
  BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22590245
[Presentation] Activation of histone/protein deacetylase SIRT1 by resveratrol induces MnSOD up-regulation via FOXO3a and improves survival of heart failure animals.2009
- Author(s)
  Kuno A, Tanno M, Miura T, Horio Y, Shimamoto K.
- Organizer
  31^<st> Congress of the European Society of Cardiology
- Place of Presentation
  Barcelona,Spain
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] The SIRT1 activator resveratrol suppresses cardiomy ocyte hypertrophy by promoting histone H3 Lys9 deacetylation and tri-methylation.2009
- Author(s)
  Kuno A, Tanno M, Yano T, Takada A, Miura T, Horio Y, Shimamoto K.
- Organizer
  82^<nd> Scientific Session of American Heart Association
- Place of Presentation
  Orlando, U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] Resveratrol, an activator of protein deacetylase SIRT1, suppresses oxidative stress-induced cell death by upregulating MnSOD expression through transactivation of FOXO3a .2008
- Author(s)
  Kuno A, Tanno M, Miura T, Horio Y, Shimamoto K.
- Organizer
  81^<st> Scientific Session of America n Heart Association
- Place of Presentation
  New Orleans,U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869
[Presentation] Activation of a protein deacetylase,SIRT1, by resveratrol suppresses progression of heart failure and improves survival by up-regulation of Mn-SOD.2008
- Author(s)
  Tanno M, Kuno A, Miki T, Miura T, Horio Y, Shimamoto K.
- Organizer
  81^<st> Scientific Session of American Heart Association
- Place of Presentation
  New Orleans, U.S.A.
- Data Source
  KAKENHI-PROJECT-20590869

1. YAMADA Mitsuhiko (10263237)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. KURACHI Yoshihisa (30142011)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. HATTA Sinnnichi (60094223)

# of Collaborated Projects: 7 results

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4. TAKUMI Toru (00222092)

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5. INANOBE Atsuhi (00270851)

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6. ATSUSHI Miyamoto (50166196)

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7. HISAKARA Shin (80336403)

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8. TAKEMURA Haruo (20106462)

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9. 高橋尚彦 (30263239)

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10. TANEMOTO Masayuki (40303945)

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11. SAKAMOTO Jun (40336392)

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12. KUNO Atsushi (30468079)

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# of Collaborated Products: 42 results
13. KURODA Masao (90028556)

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22. YAMASITA Tosiharu (50167706)

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23. HIDA Tokimasa (90464487)

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25. WATANABE Takehiko (70028356)

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26. YANAI Kazuhiko (50192787)

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27. HORI Masatsugu (20124779)

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28. TOHSE Noritsugu (80192657)

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29. YAMADA Yoichi (30284996)

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30. KOBAYASHI Takeshi (80363688)

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34. 今村育男 (90176496)

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35. 和田博 (30028295)

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36. 竹村基彦 (70207009)

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37. 浜田博喜 (10164914)

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38. 下濱俊 (60235687)

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39. 鈴木拓 (20381254)

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48. DAVID Chella S

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50. INUZUKA Eiji

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51. HARRY Steinb

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52. HENDRIK Timm

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53. CHELLA S Dav

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54. 高見昭良

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# of Collaborated Products: 1 results

Horio Yoshiyuki 堀尾 嘉幸

堀尾 嘉幸 ホリオ ヨシユキ

HORIO Yoshiyuki 堀尾 嘉幸

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Elucidation of membrane repair mechanismPrincipal Investigator

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development of a new remedy for muscular dystrophiesPrincipal Investigator

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Functional roles of SIRT1 in the differentiation of neural cellsPrincipal Investigator

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老化と体内時計Principal Investigator

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Principal Investigator

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Research Field

Research Institution

脳Sirの老化、寿命における分子機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Horio Yoshiyuki 堀尾嘉幸

堀尾嘉幸ホリオヨシユキ

HORIO Yoshiyuki 堀尾嘉幸