HANADA Kentaro 花田賢太郎

Researcher Number	30192701
Other IDs
External Links
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所品質管理研究センター, 主任研究員
Affiliation (based on the past Project Information) *help	2024: 国立感染症研究所, 品質管理研究センター, 主任研究官 2020 – 2023: 国立感染症研究所, 品質保証・管理部, 主任研究官 2006 – 2020: 国立感染症研究所, 細胞化学部, 部長 2012: 国立感染症研究所, その他部局等, 部長 2007: 国立感染研究所, 細胞化学部, 部長 … More 1998 – 2004: 国立感染症研究所, 細胞化学部, 室長 1997 – 1998: 国立感染症研究所, 細胞化学部, 主任研究官 1997: NIID,Senior Researcher, 細胞化学部, 主任研究員 1995 – 1996: 国立予防衛生研究所, 細胞化学部, 主任研究官 Less
Review Section/Research Field	Principal Investigator Environmental and hygienic pharmacy / Biological pharmacy / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological Sciences / Structural biochemistry / Functional biochemistry / Structural biochemistry / Biological Sciences Except Principal Investigator Biological pharmacy / Biological pharmacy / Biological Sciences / Biological Sciences
Keywords	Principal Investigator スフィンゴ脂質 / ゲノム編集 / セラミド / スフィンゴミエリン / Vero細胞 / 脂質輸送 / 脂質 / ワクチン / ウイルス / 宿主細胞 … More / 感染症 / ゴルジ体 / 小胞体 / 膜輸送 / セリンパルミトイル転移酵素 / レギュラトリーサイエンス / 内在性レトロウイルス / フラビウイルス / ベロ細胞 / ゲノム / クラミジア / HeLa細胞 / リン酸化 / 阻害剤 / 生体膜 / コレステロール / 突然変異株 / 遺伝性感覚神経障害 / CERT / 細胞内輸送 / CHO細胞 / ウイルス安全性評価 / アポダイズド位相差 / 位相差顕微鏡 / コロナウイルス / 細胞 / ヒト神経芽腫由来細胞 / Huh7細胞 / プリオン / ポリオウイルス / 超解像イメージング / オルガネラ膜接触部位 / 超解像蛍光顕微鏡 / PAH / 葉緑体 / オルガネラ間脂質輸送 / Huh細胞 / ウイルス感染症 / 細胞基材 / mutant / Serine palmitoyltransferase / Hereditary sensory neuropathy / Lipids / Intracellular trafficking / Sphingolipids / Ceramide / Sphingomyelin / HPA-12 / 膜脂質 / 知覚神経障害 / セリパリミトイル転移酵素 / caveolae / latex beads / proteoglycans / phagocytosis / CHO cells / GPI-anchored proteins / cholesterol / sphingolipids / リポ多糖 / カベオレ / GPI-アンカー蛋白質 / ヘパリン / 貪食 / カベオラ / ラテックスビーズ / プロテオグリカン / ファゴサイトーシス / GPIアンカー蛋白質 / プレスクトリン相同ドメイン / クラミジア菌 / 性感染症 / ワクチン細胞基材 / 細胞内寄生 / ホスホイノシチド / プレクストリン相同ドメイン / 輸送 / タンパク質リン酸化 / 輸送タンパク質 / FFATモチーフ / 多重リン酸化 / キナーゼ / 膜ドメイン / ラフト / レトロウイルスベクター / ホスファチジルイノシトール4リン酸 / 突然変異細胞 / 膜タンパク質 / ペプチド親和性クロマトグラフィー / スフィンゴシン … More Except Principal Investigator LPS / スフィンゴミエリン / スフィンゴ脂質 / コレステロール / MD-2 / Toll-like receptor / sphingolipid / ホスファチジルセリン / LCB1 / 脂質輸送 / リン酸化 / FFATモチーフ / セラミド / ウイルス / HCV / 超解像顕微鏡 / エンドソーム / 細胞生物 / ゾーン / ミトコンドリア / ゴルジ体 / 小胞体 / オルガネラ / クラミジア / メンブレンコンタクトサイト / Flavolipin / Taxol / khafrefungin / phospholipids / Baculovirus / ホスホリパーゼC / 熱帯熱マラリア原虫 / lipid raft / シンドビスウィルス / アミノ含有脂質 / アラニンスキャン法 / TLR4 / カフレファギン / 抗真菌剤 / フラボリピン / タキソール / カフレファンギン / リン脂質 / バキュロウイルス / phosphatidylcholine / phospholipase D / cardiolipin / phosphatidylserine / CHO cell / NK-κB / ホスァチジルセリン / NF-κB / マクロファージ / CD14 / ホスファチジルグリセロールリン酸 / RhoA / ホスフォリパーゼD / LCB2 / SPT(セリンパルミトイルトランスフェラーゼ) / ホスファチジルコリン / ホスフォリバーゼD / カルジオリピン / ホスファチジルグリセリン / CHO細胞 / VAP / CERT / 脂質ラフト / 脂肪滴 / ラフト / 感染実験 / 血清アルブミン / 脂肪酸 / 細胞増殖 / 細胞周期 / マラリア原虫 / Plasmodium falciparum Less

Construction of a Vero cell system that will serve as the basis for coronavirus research and vaccine developmentPrincipal Investigator
- Principal Investigator
  
  花田賢太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  National Institute of Infectious Diseases
Lipid transport via the endoplasmic reticulum communication zonesPrincipal Investigator
- Principal Investigator
  
  Hanada Kentaro
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
Construction of improved virus-susceptible host cells by genome editingPrincipal Investigator
- Principal Investigator
  
  Hanada Kentaro
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute of Infectious Diseases
Toward an integrative understanding of functional zones in organelles
- Principal Investigator
  
  Shimizu Shigeomi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Genomics-based improvement of Vero cells for virus growthPrincipal Investigator
- Principal Investigator
  
  Hanada Kentaro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute of Infectious Diseases
Molecular strategy for the prevention of Chlamydia hijacking of a host lipid transport systemPrincipal Investigator
- Principal Investigator
  
  HANADA KENTARO
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  National Institute of Infectious Diseases
Research of the regulatory mechanism of CERT-VAP interaction, from the causing factors to the caused effects.
- Principal Investigator
  
  KUMAGAI KEIGO
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
The regulatory mechanism for the CERT-VAP interaction
- Principal Investigator
  
  KUMAGAI Keigo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
Regulatory mechanism of intracellular trafficking of ceramidePrincipal Investigator
- Principal Investigator
  
  HANADA KENTARO
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Institute of Infectious Diseases
C型肝炎ウイルスの感染増殖および粒子形成における脂質の役割
- Principal Investigator
  
  脇田隆字
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
Analysis of the role of lipid in viral life cycles
- Principal Investigator
  
  WAKITA Taksji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
Determination of phosphorylation sites of the ceramide transport protein CERT, and a role of the phosphorylationPrincipal Investigator
- Principal Investigator
  
  HANADA Kentaro
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Institute of Infectious Diseases
The role of host cell membrane lipids in infection of microorganisms and in host defense mechanisms
- Principal Investigator
  
  NISHIJIMA Masahiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
細胞内スフィンゴ脂質選別輸送の分子機構と生体膜ドメイン形成にはたす役割Principal Investigator
- Principal Investigator
  
  花田賢太郎
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Infectious Diseases
Analysis of membrane lipid sorting by using an in vitro reconstitution systemPrincipal Investigator
- Principal Investigator
  
  HANADA Kentaro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Institute of Infectious Diseases
マラリア原虫の赤血球期における細胞増殖機構の解析
- Principal Investigator
  
  三田村俊秀
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Osaka University
スフィンゴシン塩基生合成の遺伝生化学的研究Principal Investigator
- Principal Investigator
  
  花田賢太郎
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
genetic and biochemical study on intracellular lipid transport and lipid functions in microdomain
- Principal Investigator
  
  NISHIJIMA Masahiro
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Infectious Diseases
A study on cooperative roles of sphingolipids and cholesterol in mammalian cell membranes.Principal Investigator
- Principal Investigator
  
  HANADA Kentaro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health

[Book] 医学のあゆみ2014
- Author(s)
  熊谷圭悟、花田賢太郎
- Total Pages
  7
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-25460086
[Journal Article] DGARM/C10orf76/ARMH3 for Ceramide Transfer Zone at the Endoplasmic ReticulumーDistal Golgi Contacts2024
- Author(s)
  Mizuike Aya、Hanada Kentaro
- Journal Title
  
  Contact
  
  Volume: 7
- DOI
  10.1177/25152564241239443
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21362
[Journal Article] The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide trafficking to the distal Golgi2023
- Author(s)
  Mizuike Aya、Sakai Shota、Katoh Kaoru、Yamaji Toshiyuki、Hanada Kentaro
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 222 Issue: 7
- DOI
  10.1083/jcb.202111069
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06417, KAKENHI-PROJECT-23K21362
[Journal Article] CERT1 mutations perturb human development by disrupting sphingolipid homeostasis2023
- Author(s)
  Gehin Charlotte、Kentaro Hanada (85名中、78番目）、et al.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 133 Issue: 10
- DOI
  10.1172/jci165019
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] Protocol for casein kinase 1γ3 CSNK1G3 gene knockout and recombinant gene expression in cultured HeLa cells2023
- Author(s)
  Goto Asako、Hanada Kentaro
- Journal Title
  
  STAR Protocols
  
  Volume: 4 Issue: 2 Pages: 102251-102251
- DOI
  10.1016/j.xpro.2023.102251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] Chlamydial Infection-Dependent Synthesis of Sphingomyelin as a Novel Anti-Chlamydial Target of Ceramide Mimetic Compounds2022
- Author(s)
  Keigo Kumagai, Shota Sakai, Masaharu Ueno, Michiyo Kataoka, Shu Kobayashi, Kentaro Hanada
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 14697-14697
- DOI
  10.3390/ijms232314697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06626, KAKENHI-PROJECT-18K06649, KAKENHI-PLANNED-17H06417
[Journal Article] Whole-Genome Sequencing of Vero E6 (VERO C1008) and Comparative Analysis of Four Vero Cell Sublines2022
- Author(s)
  Konishi Kazuhiro、Yamaji Toshiyuki、Sakuma Chisato、Kasai Fumio、Endo Toshinori、Kohara Arihiro、Hanada Kentaro、Osada Naoki
- Journal Title
  
  Frontiers in Genetics
  
  Volume: 13
- DOI
  10.3389/fgene.2022.801382
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K21362
[Journal Article] Membrane Sphingomyelin in Host Cells Is Essential for Nucleocapsid Penetration into the Cytoplasm after Hemifusion during Rubella Virus Entry2022
- Author(s)
  Mori Yoshio、Sakata Masafumi、Sakai Shota、Okamoto Toru、Nakatsu Yuichiro、Taguwa Shuhei、Otsuki Noriyuki、Maeda Yusuke、Hanada Kentaro、Matsuura Yoshiharu、Takeda Makoto
- Journal Title
  
  mBio
  
  Volume: 13 Issue: 6
- DOI
  10.1128/mbio.01698-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09586, KAKENHI-PROJECT-21K20760, KAKENHI-PROJECT-23K21362, KAKENHI-PROJECT-23K24138
[Journal Article] Compartmentalization of casein kinase 1 γ CSNK1G controls the intracellular trafficking of ceramide2022
- Author(s)
  Goto A, Sakai s, Mizuike A, Yamaji T, Hanada K
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 7 Pages: 164624-164624
- DOI
  10.1016/j.isci.2022.104624
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02435, KAKENHI-WRAPUP-22H04899, KAKENHI-PLANNED-17H06417
[Journal Article] Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT2022
- Author(s)
  Kentaro Hanada, Shota Sakai, Keigo Kumagai
- Journal Title
  
  Internal Journal of Molecular Sciences
  
  Volume: 23 Issue: 4 Pages: 2098-2098
- DOI
  10.3390/ijms23042098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-PLANNED-17H06417
[Journal Article] Ligand recognition by the lipid transfer domain of human OSBP is important for entero-virus replication2022
- Author(s)
  5. Jun Kobayashi#, Minetaro Arita*#, Shota Sakai, Hirotatsu Kojima, Miki Senda, Toshiya Senda, Kentaro Hanada and Ryuichi Kato*
- Journal Title
  
  ACS Infectious Diseases
  
  Volume: 8 Issue: 6 Pages: 1161-1170
- DOI
  10.1021/acsinfecdis.2c00108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07107, KAKENHI-PLANNED-17H06417
[Journal Article] Establishment of Vero cell lines persistently harboring a yellow fever virus 17D subgenomic replicon2022
- Author(s)
  Kyoko Saito, Kentaro Shimasaki, Masayoshi Fukasawa, Ryosuke Suzuki, Yuko Okemoto-Nakamura, Kaoru Katoh, Tomohiko Takasaki, Kentaro Hanada
- Journal Title
  
  Virus Research
  
  Volume: 322 Pages: 198935-198935
- DOI
  10.1016/j.virusres.2022.198935
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06571, KAKENHI-PROJECT-23K21362
[Journal Article] Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering Throughout the Endoplasmic Reticulum2022
- Author(s)
  Shimasaki K, Kumagai K, Sakai S, Yamaji T, Hanada K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 23 Issue: 7 Pages: 4025-4025
- DOI
  10.3390/ijms23074025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02435, KAKENHI-WRAPUP-22H04899, KAKENHI-PLANNED-17H06417
[Journal Article] 非天然骨格を有する新規CERT阻害薬の創成：産学官連携による成果創出2021
- Author(s)
  中尾直樹、小林修、花田賢太郎
- Journal Title
  
  Farumashia
  
  Volume: 57 Issue: 12 Pages: 1108-1112
- DOI
  10.14894/faruawpsj.57.12_1108
- NAID
  130008123338
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] Poliovirus-nonsusceptible Vero cell line for the World Health Organization global action plan2021
- Author(s)
  Okemoto-Nakamura Y, Someya K, Yamaji T, Saito K, Takeda M, Hanada K
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 6746-6746
- DOI
  10.1038/s41598-021-86050-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PROJECT-17H04003
[Journal Article] Seroprevalence of Flavivirus Neutralizing Antibodies in Thailand by High-Throughput Neutralization Assay: Endemic Circulation of Zika Virus before 20122021
- Author(s)
  Yamanaka Atsushi, Matsuda Mami, Okabayashi Tamaki, Pitaksajjakul Pannamthip, Ramasoota Pongrama, Saito Kyoko, Fukasawa Masayoshi, Hanada Kentaro, Matsuura Tomokazu, Muramatsu Masamichi, Shioda Tatsuo, Suzuki Ryosuke
- Journal Title
  
  mSphere
  
  Volume: 6 Issue: 4
- DOI
  10.1128/msphere.00339-21
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08362, KAKENHI-PROJECT-17H04003
[Journal Article] Golgi maturation-dependent glycoenzyme recycling controls glycosphingolipid biosynthesis and cell growth via GOLPH3.2021
- Author(s)
  Riccardo Rizzo, Domenico Russo, Kazuo Kurokawa, Alfredo Budillon, Franck Perez, Seetharaman Parashuraman, Yusuf A Hannun, Akihiko Nakano, Daniela Corda, Giovanni D’Angelo and Alberto Luini et al.,.
- Journal Title
  
  The EMBO Journal
  
  Volume: 40 Issue: 8
- DOI
  10.15252/embj.2020107238
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06650, KAKENHI-PLANNED-17H06420, KAKENHI-PROJECT-18H05275, KAKENHI-PROJECT-17K07357, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution2021
- Author(s)
  Norito Tamura, Shota Sakai, Loreto Martorell, Roser Colom, Aya Mizuike, Asako Goto, Juan Dario Ortigoza-Escobar and Kentaro Hanada
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 297 Issue: 5 Pages: 1-10
- DOI
  10.1016/j.jbc.2021.101338
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19J01972, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Identification of SYS1 as a Host Factor Required for Shiga Toxin-Mediated Cytotoxicity in Vero Cells2021
- Author(s)
  Sakuma Chisato、Sekizuka Tsuyoshi、Kuroda Makoto、Hanada Kentaro、Yamaji Toshiyuki
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 9 Pages: 4936-4936
- DOI
  10.3390/ijms22094936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PROJECT-18K14912, KAKENHI-PROJECT-21H02435, KAKENHI-PLANNED-17H06417
[Journal Article] Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT2020
- Author(s)
  Murakami Hiroaki、Tamura Norito、Enomoto Yumi、Shimasaki Kentaro、Kurosawa Kenji、Hanada Kentaro
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 12 Pages: e0243980-e0243980
- DOI
  10.1371/journal.pone.0243980
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19J01972, KAKENHI-PROJECT-16H06279, KAKENHI-PLANNED-17H06417
[Journal Article] Three‐Component, One‐Pot Tandem Sonogashira/Suzuki‐Miyaura Coupling Reactions for the Synthesis of a Library of Ceramide‐Transport Protein Inhibitors Designed In Silico2020
- Author(s)
  Ueno Masaharu、Miyoshi Norikazu、Hanada Kentaro、Kobayashi Shu
- Journal Title
  
  Asian Journal of Organic Chemistry
  
  Volume: 9 Issue: 2 Pages: 267-273
- DOI
  10.1002/ajoc.201900689
- NAID
  120007001416
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05479, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Identification of Characteristic Genomic Markers in Human Hepatoma HuH-7 and Huh7.5.1-8 Cell Lines2020
- Author(s)
  Kawamoto M#, Yamaji T#, Saito K, Shirasago Y, Satomura K, Endo T, Fukasawa M, Hanada K, Osada N.
- Journal Title
  
  Front Genet
  
  Volume: 11 Pages: 546106-546106
- DOI
  10.3389/fgene.2020.546106
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H04003
[Journal Article] Sphingolipid Metabolism at the ER-Golgi Contact Zone and Its Impact on Membrane Trafficking2020
- Author(s)
  Goto Asako、Mizuike Aya、Hanada Kentaro
- Journal Title
  
  Contact
  
  Volume: 3 Pages: 1-13
- DOI
  10.1177/2515256420959514
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] SNAP23 deficiency causes severe brain dysplasia through the loss of radial glial cell polarity2020
- Author(s)
  Kunii M、Noguchi Y、Yoshimura S、Kanda S、Iwano T、Avriyanti E、Atik N、Sato T、Sato K、Ogawa M、Harada A
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 220 Issue: 1 Pages: 1-21
- DOI
  10.1083/jcb.201910080
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06435, KAKENHI-PROJECT-19K22514, KAKENHI-PROJECT-18H02594, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422, KAKENHI-PROJECT-19H03181, KAKENHI-PROJECT-20K22655, KAKENHI-PLANNED-19H05711, KAKENHI-PROJECT-20H00466
[Journal Article] Blood group P1 antigen?bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors2020
- Author(s)
  Morimoto K, Suzuki N, Tanida I, Kakuta S, Furuta Y, Uchiyama Y, Hanada K, Suzuki Y, Yamaji T.
- Journal Title
  
  J Biol Chem
  
  Volume: 295 Issue: 28 Pages: 9490-9501
- DOI
  10.1074/jbc.ra120.013926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PROJECT-20K06520, KAKENHI-PUBLICLY-20H05342, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Impaired actin dynamics and suppression of Shank2-mediated spine enlargement in cortactin knockout mice2020
- Author(s)
  Tanaka Shinji、Masuda Yasutaka、Harada Akihiro、Okabe Shigeo
- Journal Title
  
  Microscopy
  
  Volume: 69 Issue: 1 Pages: 44-52
- DOI
  10.1093/jmicro/dfaa001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06413, KAKENHI-PUBLICLY-18H04727, KAKENHI-PROJECT-17H01387
[Journal Article] Comparative characterization of flavivirus production in two cell lines: Human hepatoma-derived Huh7.5.1-8 and African green monkey kidney-derived Vero2020
- Author(s)
  Kyoko Saito, Masayoshi Fukasawa, Yoshitaka Shirasago, Ryosuke Suzuki, Naoki Osada, Toshiyuki Yamaji, Takaji Wakita, Eiji Konishi, Kentaro Hanada
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 4 Pages: e0232274-e0232274
- DOI
  10.1371/journal.pone.0232274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08362, KAKENHI-PROJECT-17K07357, KAKENHI-PLANNED-18H05511, KAKENHI-PROJECT-17H04003
[Journal Article] Palmitoylated CKAP4 regulates mitochondrial functions through an interaction with VDAC2 at ER?mitochondria contact sites2020
- Author(s)
  Harada Takeshi、Sada Ryota、Osugi Yoshito、Matsumoto Shinji、Matsuda Tomoki、Hayashi-Nishino Mitsuko、Nagai Takeharu、Harada Akihiro、Kikuchi Akira
- Journal Title
  
  Journal of Cell Science
  
  Volume: 133 Issue: 21
- DOI
  10.1242/jcs.249045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06956, KAKENHI-PROJECT-20K07357, KAKENHI-PROJECT-16H06374, KAKENHI-PROJECT-18H02594, KAKENHI-PROJECT-17K08633, KAKENHI-PROJECT-19K22563, KAKENHI-PROJECT-16H06276, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422
[Journal Article] The activity of Sac1 across ER?TGN contact sites requires the four-phosphate-adaptor-protein-12019
- Author(s)
  Venditti Rossella、Masone Maria Chiara、Rega Laura Rita、Di Tullio Giuseppe、Santoro Michele、Polishchuk Elena、Serrano Ivan Castello、Olkkonen Vesa M.、Harada Akihiro、Medina Diego L.、La Montagna Raffaele、De Matteis Maria Antonietta
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 218 Issue: 3 Pages: 783-797
- DOI
  10.1083/jcb.201812021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422, KAKENHI-PROJECT-18H02594
[Journal Article] A CRISPR screen identifies LAPTM4A and TM9SF proteins as glycolipid-regulating factors2019
- Author(s)
  Yamaji T, Sekizuka T, Tachida Y, Sakuma C, Morimoto K, Kuroda M, Hanada K
- Journal Title
  
  iScience
  
  Volume: 11 Pages: 409-424
- DOI
  10.1016/j.isci.2018.12.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PLANNED-17H06417
[Journal Article] 蛍光脂質2019
- Author(s)
  中村浩之, 花田賢太郎
- Journal Title
  
  実験医学別冊「脂質解析ハンドブック」
  
  Volume: - Pages: 241-249
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] A CRISPR Screen Using Subtilase Cytotoxin Identifies SLC39A9 as a Glycan-Regulating Factor2019
- Author(s)
  Yamaji Toshiyuki、Hanamatsu Hisatoshi、Sekizuka Tsuyoshi、Kuroda Makoto、Iwasaki Norimasa、Ohnishi Makoto、Furukawa Jun-ichi、Yahiro Kinnosuke、Hanada Kentaro
- Journal Title
  
  iScience
  
  Volume: 15 Pages: 407-420
- DOI
  10.1016/j.isci.2019.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PROJECT-19K07534, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] スフィンゴリン脂質2019
- Author(s)
  花田賢太郎
- Journal Title
  
  実験医学別冊「脂質解析ハンドブック」
  
  Volume: - Pages: 109-118
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] Roles of collagen XXV and its putative receptors PTP s/d in intramuscular motor innervation and congenital cranial dysinnervation disorder2019
- Author(s)
  Haruka Munezane, Hiroaki Oizumi, Tomoko Wakabayashi, Shu Nishio, Tomoko Hirasawa, Takashi Sato, Akihiro Harada, Tomoyuki Yoshida, Takahiro Eguchi, Yuji Yamanashi, Tadafumi Hashimoto, Takeshi Iwatsubo
- Journal Title
  
  Cell Reports
  
  Volume: 29 Issue: 13 Pages: 4362-4376
- DOI
  10.1016/j.celrep.2019.11.112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07364, KAKENHI-PROJECT-19K06435, KAKENHI-ORGANIZER-17H06413, KAKENHI-PUBLICLY-19H04744, KAKENHI-PROJECT-17K07091, KAKENHI-PROJECT-17H01532, KAKENHI-PROJECT-17H04193
[Journal Article] Natural ligand-nonmimetic inhibitors to the lipid transfer protein CERT2019
- Author(s)
  Naoki Nakao, Masaharu Ueno, Shota Sakai, Daichi Egawa, Hiroyuki Hanzawa, Shohei Kawasaki, Keigo Kumagai, Makoto Suzuki, Shu Kobayashi and Kentaro Hanada
- Journal Title
  
  Communications Chemistry
  
  Volume: 2 Issue: 1 Pages: 20-20
- DOI
  10.1038/s42004-019-0118-3
- NAID
  120006558385
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417, KAKENHI-PROJECT-19K05479, KAKENHI-PROJECT-15H05698
[Journal Article] Characterization of monoclonal antibodies recognizing each extracellular loop domain of occludin2019
- Author(s)
  Shimizu Yoshimi、Shirasago Yoshitaka、Suzuki Takeru、Hata Tomoyuki、Kondoh Masuo、Hanada Kentaro、Yagi Kiyohito、Fukasawa Masayoshi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 166 Issue: 4 Pages: 297-308
- DOI
  10.1093/jb/mvz037
- NAID
  40022023629
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417, KAKENHI-PROJECT-18H02856
[Journal Article] Organelle contacts: Sub‐organelle zones to facilitate rapid and accurate inter‐organelle trafficking of lipids2019
- Author(s)
  Hanada Kentaro
- Journal Title
  
  Traffic
  
  Volume: 21 Issue: 1 Pages: 189-196
- DOI
  10.1111/tra.12716
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Chlamydia trachomatis‐infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 22019
- Author(s)
  Tachida Yuriko、Kumagai Keigo、Sakai Shota、Ando Shuji、Yamaji Toshiyuki、Hanada Kentaro
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 3 Pages: 519-529
- DOI
  10.1002/1873-3468.13632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07357, KAKENHI-PROJECT-18K06649, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] Structure, functions and regulation of CERT, a lipid‐transfer protein for the delivery of ceramide at the ER?Golgi membrane contact sites2019
- Author(s)
  Kumagai Keigo、Hanada Kentaro
- Journal Title
  
  FEBS Letters
  
  Volume: 593 Issue: 17 Pages: 2366-2377
- DOI
  10.1002/1873-3468.13511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06417
[Journal Article] 1.A PRNP-Disrupted Human Neuroblastoma Cell Line and Its Stable Transformants Expressing Prion Protein Variants2019
- Author(s)
  Yuko Okemoto-Nakamura , Isei Tanida, Toshiyuki Yamaji , Kentaro Hanada , Ken’ichi Hagiwara
- Journal Title
  
  BPB Reports
  
  Volume: 2 Pages: 73-79
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04003
[Journal Article] Thermostable hepatitis C virus JFH1-derived variant isolated by adaptation to Huh7.5.1 cells2018
- Author(s)
  Shirasago Yoshitaka、Fukazawa Hidesuke、Aizaki Hideki、Suzuki Tetsuro、Suzuki Takeru、Sugiyama Kazuo、Wakita Takaji、Hanada Kentaro、Abe Ryo、Fukasawa Masayoshi
- Journal Title
  
  Journal of General Virology
  
  Volume: 99 Issue: 10 Pages: 1407-1417
- DOI
  10.1099/jgv.0.001117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09447, KAKENHI-PROJECT-17H04003, KAKENHI-PROJECT-18H02661, KAKENHI-PROJECT-15K09034, KAKENHI-PROJECT-16K08260
[Journal Article] Novel endogenous simian retroviral integrations in Vero cells: implications for quality control of a human vaccine cell substrate2018
- Author(s)
  Sakuma Chisato、Sekizuka Tsuyoshi、Kuroda Makoto、Kasai Fumio、Saito Kyoko、Ikeda Masaki、Yamaji Toshiyuki、Osada Naoki、Hanada Kentaro
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 644-644
- DOI
  10.1038/s41598-017-18934-2
- NAID
  120006401475
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01623, KAKENHI-PROJECT-17H04003, KAKENHI-PLANNED-18H05511
[Journal Article] The Rab11-binding protein RELCH/KIAA1468 controls intracellular cholesterol distribution.2018
- Author(s)
  Sobajima T., Yoshimura S*., Maeda T., Miyata H., Miyoshi E., and Harada A*. （*共同責任著者）
- Journal Title
  
  J Cell Biol
  
  Volume: pii: jcb.201709123 Issue: 5 Pages: 1-15
- DOI
  10.1083/jcb.201709123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07348, KAKENHI-PROJECT-16K15171, KAKENHI-PROJECT-15H04668, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-16H05226, KAKENHI-PLANNED-17H06422
[Journal Article] Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy2018
- Author(s)
  Shimasaki K, Watanabe-Takahashi M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, Hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, Nishikawa K.
- Journal Title
  
  Genes to Cells
  
  Volume: 23 Issue: 1 Pages: 22-34
- DOI
  10.1111/gtc.12544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07044, KAKENHI-PLANNED-15H05930, KAKENHI-PROJECT-17H03805, KAKENHI-PROJECT-15K08480, KAKENHI-ORGANIZER-17H06413, KAKENHI-PROJECT-17H03821
[Journal Article] 小胞体連携ゾーンを介した脂質輸送機構2018
- Author(s)
  水池彩、花田賢太郎
- Journal Title
  
  生体の科学
  
  Volume: 69 Pages: 541-545
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] Phosphoinositide binding by the PH domain in ceramide transfer protein (CERT) is inhibited by hyperphosphorylation of an adjacent serine-repeat motif2018
- Author(s)
  Sugiki Toshihiko、Egawa Daichi、Kumagai Keigo、Kojima Chojiro、Fujiwara Toshimichi、Takeuchi Koh、Shimada Ichio、Hanada Kentaro、Takahashi Hideo
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 28 Pages: 11206-11217
- DOI
  10.1074/jbc.ra118.002465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-PUBLICLY-17H05836, KAKENHI-PUBLICLY-17H05873, KAKENHI-PLANNED-17H06417, KAKENHI-PUBLICLY-18H04626, KAKENHI-PROJECT-18H02393, KAKENHI-PROJECT-17H06097, KAKENHI-PROJECT-17H03641
[Journal Article] A Novel Contact by a Novel Protein Complex Supports Cholesterol Transport to the Endoplasmic Reticulum2018
- Author(s)
  Harada Akihiro
- Journal Title
  
  Contact
  
  Volume: 1 Pages: 77968-77968
- DOI
  10.1177/2515256418779685
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06413, KAKENHI-PLANNED-17H06422, KAKENHI-PROJECT-18H02594, KAKENHI-PROJECT-16K15171
[Journal Article] Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT2018
- Author(s)
  Kumagai Keigo、Elwell Cherilyn A.、Ando Shuji、Engel Joanne N.、Hanada Kentaro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 505 Issue: 4 Pages: 1070-1076
- DOI
  10.1016/j.bbrc.2018.09.168
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06649, KAKENHI-PLANNED-17H06417
[Journal Article] Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites2018
- Author(s)
  Kentaro Hanada
- Journal Title
  
  Journal of Lipid Research
  
  Volume: 59 Issue: 8 Pages: 1341-1366
- DOI
  10.1194/jlr.r085324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06417
[Journal Article] Organelle Contact Sites2017
- Author(s)
  Hanada Kentaro
- Journal Title
  
  Advances in Experimental Medicine and Biology
  
  Volume: 997 Pages: 69-81
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Journal Article] In Vitro Assay to Extract Specific Lipid Types from Phospholipid Membranes Using Lipid-Transfer Proteins: A Lesson from the Ceramide Transport Protein CERT2017
- Author(s)
  Hanada Kentaro、Sugiki Toshihiko
- Journal Title
  
  “Lipidomics” (Ed., Paul Wood). Series: Neuromethods
  
  Volume: 125 Pages: 81-98
- DOI
  10.1007/978-1-4939-6946-3_6
- ISBN
  9781493969449, 9781493969463
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Journal Article] Meeting report: The first meeting of the national control laboratories for vaccines and biologicals in the Western pacific in 20162016
- Author(s)
  Hokyung Oh, Jinho Shin, Manabu Ato, Xiao Ma, David Williams, Kiwon Han, Yang Jin Kim, Hyung Goo Kang, Kikyung Jung, Kentaro Hanada, Masaki Ochiai, Pham Van Hug, Sangmi Park, and Chiyoung Ahn
- Journal Title
  
  Osong Public Health and Research Perspectives
  
  Volume: 8 Issue: 1 Pages: 91-103
- DOI
  10.24171/j.phrp.2017.8.1.13
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14993
[Journal Article] Sphingolipid metabolism and interorganellar transport: localization of sphingolipid enzymes and lipid transfer proteins2015
- Author(s)
  Toshiyuki Yamaji and Kentaro Hanada
- Journal Title
  
  Traffic
  
  Volume: 16 Issue: 2 Pages: 101-122
- DOI
  10.1111/tra.12239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460086, KAKENHI-PROJECT-25670065, KAKENHI-PROJECT-26440069
[Journal Article] 効率的な細胞内セラミド輸送の仕組みとその制御2014
- Author(s)
  熊谷圭悟, 花田賢太郎
- Journal Title
  
  医学の歩み
  
  Volume: 248 Pages: 1125-1131
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] A role for sphingomyelin-rich lipid domains in the accumulation of phosphatidylinositol-4,5-bisphosphate to the cleavage furrow during cytokinesis2014
- Author(s)
  Abe M, Makino A, Hullin-Matsuda F, Kamijo K, Ohno-Iwashita Y, Hanada K, Mizuno H, Miyawaki A, and Kobayashi T
- Journal Title
  
  Mol Cell Biol
  
  Volume: 32 Issue: 8 Pages: 1396-1407
- DOI
  10.1128/mcb.06113-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23790115
[Journal Article] Interorganelle trafficking of lipids: preface for the thematic review series2014
- Author(s)
  Kentaro Hanada and Dennis Voelker
- Journal Title
  
  Traffic
  
  Volume: 15 Issue: 9 Pages: 889-894
- DOI
  10.1111/tra.12193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460086
[Journal Article] Establishment of HeLa cell mutants deficient in sphingolipid-related genes by using TALENs2014
- Author(s)
  Yamaji T, and Hanada K
- Journal Title
  
  PLoS ONE
  
  Volume: 9 Issue: 2 Pages: e88124-e88124
- DOI
  10.1371/journal.pone.0088124
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23770164, KAKENHI-PROJECT-25670065
[Journal Article] The genome landscape of the African green monkey kidney-derived Vero cell line.2014
- Author(s)
  Osada N, Kohara A, Yamaji T, Hirayama N, Kasai F, Sekizuka T, Kuroda M, Hanada K
- Journal Title
  
  DNA Res.
  
  Volume: 21 Issue: 6 Pages: 673-683
- DOI
  10.1093/dnares/dsu029
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23113008, KAKENHI-PLANNED-23117005, KAKENHI-PROJECT-25670065, KAKENHI-PROJECT-26251040, KAKENHI-PROJECT-26440069
[Journal Article] Co-evolution of sphingomyelin and the ceramide transport protein CERT2014
- Author(s)
  Hanada K
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1841 Issue: 5 Pages: 704-719
- DOI
  10.1016/j.bbalip.2013.06.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-25460086, KAKENHI-PROJECT-25670065
[Journal Article] Phosphoregulation of CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells2014
- Author(s)
  Kumagai K, Kawano-Kawada M, and Hanada K
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Issue: 15 Pages: 10748-10760
- DOI
  10.1074/jbc.m113.528380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-25460086, KAKENHI-PROJECT-25670065
[Journal Article] Interorganelle trafficking of lipids: preface for the thematic review series2014
- Author(s)
  Kentaro Hanada and Dennis Voelker
- Journal Title
  
  Traffic
  
  Volume: 15 Pages: 889-894
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25670065
[Journal Article] 効率的な細胞内セラミド輸送の仕組みとその制御2014
- Author(s)
  熊谷圭悟、花田賢太郎
- Journal Title
  
  医学の歩み
  
  Volume: 243 Pages: 1125-1131
- Data Source
  KAKENHI-PROJECT-25670065
[Journal Article] Structural basis for the Golgi association by the pleckstrin homology domain of the ceramide trafficking protein (CERT)2012
- Author(s)
  Sugiki T, Takeuchi K, Yamaji T, Takano T, Tokunaga Y, Kumagai K, Hanada K, Takahashi H, and Shimada I
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 40 Pages: 33706-33718
- DOI
  10.1074/jbc.m112.367730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23770164, KAKENHI-PROJECT-23790064, KAKENHI-PROJECT-23790118, KAKENHI-PROJECT-24370048, KAKENHI-PROJECT-24890263, KAKENHI-PUBLICLY-23107735, KAKENHI-PUBLICLY-24102524
[Journal Article] Reconstitution assay system for ceramide transport with semi-intact cells2012
- Author(s)
  Kumagai K, Nishijima M, and Hanada K
- Journal Title
  
  Methods Cell Biol
  
  Volume: 108 Pages: 117-129
- DOI
  10.1016/b978-0-12-386487-1.00006-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23790118
[Journal Article] Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum2012
- Author(s)
  Hullin-Matsuda F, Tomishige N, Sakai S, Ishitsuka R, Ishii K, Makino A, Greimel P, Abe M, Laviad EL, Lagarde M, Vidal H, Saito T, Osada H, Hanada K, Futerman AH, and Kobayashi T
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Issue: 30 Pages: 24397-24411
- DOI
  10.1074/jbc.m112.356733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054, KAKENHI-PROJECT-23790115
[Journal Article] Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development2011
- Author(s)
  Elwell CA, Jiang S, Kim JH, Lee A, Wittmann T, Hanada K, Melancon P, and Engel JN
- Journal Title
  
  PLoS Pathog
  
  Volume: 7 Issue: 9 Pages: e1002198-e1002198
- DOI
  10.1371/journal.ppat.1002198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] Intracellular trafficking of ceramide by ceramide transfer protein2010
- Author(s)
  Hanada K
- Journal Title
  
  Proc Jpn Acad Ser B Phys Biol Sci
  
  Volume: 86 Pages: 426-437
- NAID
  130000258738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturb a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis2010
- Author(s)
  Yamaji T, Nishikawa K, and Hanada K
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Issue: 46 Pages: 35505-35518
- DOI
  10.1074/jbc.m110.154229
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] Real-time assay method of lipid extraction activity2010
- Author(s)
  Sugiki T, Takahashi H, Nagasu M, Hanada K, Shimada I
- Journal Title
  
  Anal Biochem
  
  Volume: 399 Issue: 2 Pages: 162-167
- DOI
  10.1016/j.ab.2009.12.031
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] Intracellular trafficking of ceramide by ceramide transfer protein2010
- Author(s)
  Kentaro Hanada
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 86 Pages: 426-437
- NAID
  130000258738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] Crystal structures of the CERT START domain with inhibitors provide insights into the mechanism of ceramide transfer2010
- Author(s)
  Kudo N, Kumagai K, Matsubara R, Kobayashi S, Hanada K, Wakatsuki S, and Kato R
- Journal Title
  
  J Mol Biol
  
  Volume: 396 Issue: 2 Pages: 245-251
- DOI
  10.1016/j.jmb.2009.12.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370054
[Journal Article] CERT-mediated trafficking of ceramide.2009
- Author(s)
  Kentaro Hanada, Keigo Kumagai, Nario Tomishige, Toshiyuki Yamaji
- Journal Title
  
  Biochim. Biophys. Acta 1791
  
  Pages: 684-691
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Casein kinase Iγ2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin.2009
- Author(s)
  Nario Tomishige, Keigo Kumagai, Jun Kusuda, Masahiro Nishijima, Kentaro Hanada
- Journal Title
  
  Mol. Biol. Cell 20
  
  Pages: 348-357
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] CERT-mediated trafficking of ceramide2009
- Author(s)
  Kentaro Hanada
- Journal Title
  
  Biochimica et Biophysica Acta 1791
  
  Pages: 684-691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Cellular vimentin content regulates the protein level of hepatitis C virus core protein and the hepatitis C virus production in cultured cells.2009
- Author(s)
  Nitahara-Kasahara Y, 他5名Wakita T, Hanada K, Miyamura T, Nishijima M.
- Journal Title
  
  Virol 383(2)
  
  Pages: 319-27
- Data Source
  KAKENHI-PROJECT-19041074
[Journal Article] Casein kinase Iγ2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin2009
- Author(s)
  N. Tomishige, K. Kumagai, J. Kusuda, M. Nishijima and K. Hanada
- Journal Title
  
  Mol. Biol. Cell 20
  
  Pages: 348-357
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Protein phosphatase 2C is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes2008
- Author(s)
  S. Saito, H. Matsui, M. Kawano, K. Kumagai, N. Tomishige, K. Hanada, S. Echigo, S. Tamura and T. Kobayashi
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 6584-6593
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide2008
- Author(s)
  N. Kudo, K. Kumagai, N. Tomishige, T. Yamaji, S. Wakatsuki, M. Nishijima, K. Hanada and R. Kato
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 488-493
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.2008
- Author(s)
  Norio Kudo, Keigo Kumagai, Nario Tomishige, Toshiyuki Yamaji, Soichi Wakatsuki, Masahiro Nishijima, Kentaro Hanada, Ryuichi Kato
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 105
  
  Pages: 488-493
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Critical role of virion -associated cholesterol and sphingolipid in hepatitis C virus infection.2008
- Author(s)
  Aizaki H, M, 他7名Hanada K, Matsuura Y, Lai MM, Miyamura T, Wakita T, Suzuki T.
- Journal Title
  
  J Virol 82(12)
  
  Pages: 5715-24
- Data Source
  KAKENHI-PROJECT-19041074
[Journal Article] CERT and intracellular trafficking of ceramide2007
- Author(s)
  Kentaro Hanada
- Journal Title
  
  Biochimica et Biophysica Acta 1771
  
  Pages: 644-653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Inter-organelle trafficking of ceramide is regulated by phosphorylation-dependent co-operativity between the PH and START domains of CERT.2007
- Author(s)
  Keigo Kumagai, Miyuki Kawano, Fumiko Shinkai-Ouchi, Masahiro Nishijima, Kentaro Hanada
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 17758-17766
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] CERT and intracellular trafficking of ceramide.2007
- Author(s)
  Kentaro Hanada, Keigo Kumagai, Nario Tomishige, Miyuki Kawano
- Journal Title
  
  Biochim. Biophys. Acta 1771
  
  Pages: 644-653
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Inter-organelle trafficking of ceramide is regulated by phosphorylation-dependent co-operativity between the PH and START domains of CERT2007
- Author(s)
  K. Kumagai, M. Kawano, F. Shinkai-Ouchi, M. Nishijima and K. Hanada
- Journal Title
  
  J. Biol. Chem 282
  
  Pages: 17758-17766
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide2006
- Author(s)
  Kentaro Hanada
- Journal Title
  
  Molecular and Cellular Biochemistry 286
  
  Pages: 23-31
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] 脂質のオルガネラ間トラフィック2006
- Author(s)
  花田賢太郎
- Journal Title
  
  実験医学 24
  
  Pages: 912-917
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] 生命科学の中央舞台に歩み入る膜脂質ダイナミズム2006
- Author(s)
  花田賢太郎
- Journal Title
  
  実験医学 24
  
  Pages: 900-904
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT2006
- Author(s)
  M. Kawano, K. Kumagai, M. Nishijima and K. Hanada
- Journal Title
  
  J. Biol. Chem 281
  
  Pages: 30279-30288
- Data Source
  KAKENHI-PROJECT-18370049
[Journal Article] Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT.2006
- Author(s)
  Miyuki Kawano, Keigo Kumagai, Masahiro Nishijima, Kentaro Hanada
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 30279-30288
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] 小胞体－遠位ゴルジ体間セラミド輸送ゾーンに必要なDGARM/C10orf762023
- Author(s)
  花田賢太郎、水池彩
- Organizer
  第16回セラミド研究会学術集会・第17回スフィンゴテラピー研究会合同年会
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] C10orf76－PI4KB軸による遠位ゴルジ体へのCERT依存性セラミド輸送の場の構築2023
- Author(s)
  水池彩、酒井祥太、加藤薫、山地俊之、花田賢太郎
- Organizer
  第65回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] Introductory remarks for the session of Breakthrough Strategies to Study Sphingolipids’ Structure and Functions2023
- Author(s)
  Hanada Kentaro
- Organizer
  FEBS special meeting in “Sphingolipid biology: The dawn of a new era”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] Vero細胞ゲノムにコードされるサル内在性レトロウイルスの特性解析2022
- Author(s)
  齊藤恭子、佐久間智理、山地俊之、花田賢太郎
- Organizer
  第69回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] 黄熱ウイルス17D株サブゲノミックレプリコンを持続的に保持するVero細胞の特性解析2022
- Author(s)
  齊藤恭子、島﨑健太朗、深澤征義、鈴木亮介、中村（桶本）優子、加藤薫、高崎智彦、花田賢太郎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] カゼインキナーゼ1γのC末端脂質修飾に依存した細胞内局在変化がスフィンゴミエリン生合成におけるセラミド輸送を制御する2022
- Author(s)
  後藤麻子、酒井祥太、水池彩、山地俊之、花田賢太郎
- Organizer
  第64回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] How does lipid transport between organelles in the cell occur, and how is it regulated? A lesson from the ceramide transport protein CERT2022
- Author(s)
  Kentaro Hanada
- Organizer
  Centenary Institute Tuesday Seminar, the University of Sydney
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Casein kinase 1γの分布区画化が小胞体―ゴルジ体間セラミド輸送を制御する2022
- Author(s)
  後藤麻子、酒井祥太、水池彩、山地俊之、花田賢太郎
- Organizer
  第15回セラミド研究会学術集会・第16回スフィンゴテラピー研究会合同年会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] C10orf76―PI4KB軸によって遠位ゴルジ体へのCERT依存性セラミド輸送が組織化される2022
- Author(s)
  水池彩、酒井祥太、加藤薫、山地俊之、花田賢太郎
- Organizer
  第65回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] SARS CoV-2 mRNA/LNPワクチンの製造と品質情報について2022
- Author(s)
  花田賢太郎
- Organizer
  日本薬学会関東支部会、第47回学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] Introductory remarks for the session of Trafficking and Metabolism2021
- Author(s)
  Kentaro Hanada
- Organizer
  11th International Ceramide Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 小胞体－ゴルジ体膜接触ゾーンで働くセラミド輸送タンパク質CERTの機能制御とその破綻2021
- Author(s)
  花田賢太郎
- Organizer
  第142回日本薬学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] COOL STRUTTIN’ オルガネラ間脂質輸送2021
- Author(s)
  花田賢太郎
- Organizer
  第63回日本脂質生化学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] カゼインキナーゼ1γのC末端領域依存的な細胞内局在の変化がスフィンゴミエリン生合成におけるセラミド輸送に影響を及ぼす2021
- Author(s)
  後藤麻子，水池彩，山地俊之，花田賢太郎
- Organizer
  第73回日本細胞生物学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 宿主細胞からクラミジア・トラコマティスへのセラミドフローを担う分子機構2021
- Author(s)
  熊谷圭悟、杉木俊彦、児嶋長次郎、花田賢太郎
- Organizer
  第94回日本生化学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Characteristics of SARS-CoV-2 mRNA/LNP vaccines and their official verification2021
- Author(s)
  花田賢太郎
- Organizer
  第95回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-23K21362
[Presentation] 生物の合理性が育んだオルガネラ間脂質輸送システム：近距離で早く正確にものを運ぶ2021
- Author(s)
  花田賢太郎
- Organizer
  第73回日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 抗がん剤OSW-1によるゴルジ体ストレス応答におけるPtdIns transfer protein beta（PITPNB）の機能解析2021
- Author(s)
  佐々木桂奈江、森下史、足立拓弥、渡部雄斗、若林貞夫、櫻井香里、養王田正文、山地俊之、花田賢太郎、吉田秀郎
- Organizer
  第73回日本細胞生物学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] アポダイズド位相差顕微鏡による無染色・非侵襲での細胞内微細構造動態の観察2021
- Author(s)
  島﨑健太朗, 加藤薫, 中村優子, 齊藤恭子, 深澤征義, 花田賢太郎
- Organizer
  第30回日本バイオイメージング学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] CERTの多重リン酸化依存的な機能抑制における塩基性アミノ酸クラスターの役割2021
- Author(s)
  後藤麻子，江川大地，冨重斉生，熊谷圭悟，花田賢太郎
- Organizer
  第63回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 寄生細菌クラミジアは宿主細胞のセラミドをいかにして利用するのか2021
- Author(s)
  花田賢太郎
- Organizer
  日本薬学会生物系薬学部会主催第21回Pharmaco-Hematologyシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 抗がん剤OSW-1が引き起こすゴルジ体ストレス依存性細胞死はホスホイノシタイド代謝因子によって制御される2021
- Author(s)
  佐々木桂奈江、森下史、足立拓弥、渡部雄斗、若林貞夫、櫻井香里、養王田正文、山地俊之、花田賢太郎、吉田秀郎
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 小胞体－ゴルジ体間セラミド輸送ゾーンの形成に重要なPI4P関連因子の解析2021
- Author(s)
  水池彩, 酒井祥太, 加藤薫, 山地俊之, 花田賢太郎
- Organizer
  第44回日本分子生物学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 非天然骨格を有するCERT阻害剤のSBDD研究2020
- Author(s)
  中尾直樹、上野雅晴、酒井祥太、江川大地、半沢宏之、川崎祥平、熊谷圭悟、鈴木誠小林修、花田賢太郎
- Organizer
  第141回日本薬学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 寄生細菌クラミジアは宿主細胞のセラミドをいかにして利用するのか2020
- Author(s)
  花田賢太郎
- Organizer
  日本薬学会生物系薬学部会主催　第21回Pharmaco-Hematologyシンポジウム～薬学の基礎と臨床～
- Invited
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] 精神発達遅滞との関連が示唆されるセラミド輸送タンパク質遺伝子CERT1上のミスセンス変異の解析2020
- Author(s)
  田村律人、村上博昭、黒澤健司、花田賢太郎
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] セラミド輸送タンパク質CERTのセリンリピートモチーフにおける機能獲得型変異は精神発達遅滞の原因となる2020
- Author(s)
  村上博昭、田村律人、榎本友美、黒澤健司、花田賢太郎
- Organizer
  第65回日本人類遺伝学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] セラミドとの構造類似性のない新規CERT阻害剤の開発2020
- Author(s)
  花田賢太郎
- Organizer
  第14回スフィンゴテラピー研究会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 高浸透圧ストレスにより誘導されるセラミド輸送タンパク質 CERT のリン酸化およびその責任キナーゼに関する解析2020
- Author(s)
  島﨑健太朗、熊谷圭悟、花田賢太郎
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] P1糖鎖エピトープを有する糖タンパク質の志賀毒素受容体としての機能解析2020
- Author(s)
  森本貫太、鈴木詔子、谷田以誠、角田宗一郎、古田陽子、内山安男、花田賢太郎、鈴木佑典、山地俊之
- Organizer
  第39回日本糖質学会年会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] オルガネラ間脂質輸送の研究：遺伝学と生化学と細胞生物学との幸せなコラボレーションーション2020
- Author(s)
  花田賢太郎
- Organizer
  第72回日本細胞生物学会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 精神発達遅滞との関連が示唆されるセラミド輸送タンパク質遺伝子CERT1上のドミナント遺伝性変異の解析2020
- Author(s)
  田村律人、村上博昭、黒澤健司、花田賢太郎
- Organizer
  第93回日本生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] バイオロジクスにおけるウイルス安全性確保の新潮流2020
- Author(s)
  花田賢太郎
- Organizer
  第141回日本薬学会
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] 初心者のための入門講座：感染症研究へのゲノム編集技術の応用 CRISPR/Cas9システムによる新規の細胞株の創出2020
- Author(s)
  中村(桶本)優子、染谷健二、齊藤恭子、山地俊之、竹田誠、花田賢太郎
- Organizer
  第69回日本感染症学会東日本地方会学術集会・第69回日本化学療法学会東日本支部総会合同学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] 小胞体-ゴルジ体連携ゾーンにおけるCERTの機能制御に関する因子の探索2020
- Author(s)
  水池彩、酒井祥太、山地俊之、花田賢太郎
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] ヒト肝癌由来Huh7.5.1-8細胞とアフリカミドリザル腎由来Vero細胞におけるフラビウイルス産生能の比較解析2019
- Author(s)
  齊藤恭子, 深澤征義, 白砂圭崇, 鈴木亮介, 山地俊之, 脇田隆字, 小西英二, 花田賢太郎
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] Systematic development of natural ligand-nonmimetic inhibitors to the ceramide transport protein CERT2019
- Author(s)
  Hanada, K
- Organizer
  FEBS special meeting in “Sphingolipid biology in health and disease”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Construction of a yellow fever virus subgenomic replicon system and characterization of cell lines harboring the replicon2019
- Author(s)
  Kyoko Saito, Masayoshi Fukasawa, Ryosuke Suzuki, Tomohiko Takasaki, Kentaro Hanada
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] クラミジアのエフェクタータンパク質IncDと宿主細胞由来のセラミド輸送タンパク質CERTのPHドメインとの結合にはIncDのN末領域とC末領域が必要である2019
- Author(s)
  熊谷圭悟, 花田賢太郎
- Organizer
  第３回　オルガネラゾーン研究会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Chlamydia trachomatis requires host ceramide-transport protein CERT but not sphingomyelin synthases for the infection and proliferation in HeLa cells2019
- Author(s)
  Kumagai K, Tachida Y, Sakai S, Yamaji T, Hanada K
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] Structural basis for the specific association between the Chlamydia trachomatis inclusion membrane protein IncD and the PH domain of the ceramide transport protein CERT2019
- Author(s)
  Sugiki T, Kumagai K, Shinya S, Kobayashi N, Egawa D, Fujiwara T, Hanada K, Kojima C
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] Natural ligand-nonmimetic inhibitors of the lipid-transfer protein2019
- Author(s)
  Sakai S, Nakao N, Ueno M, Egawa D, Hanzawa H, Kawasaki S, Kumagai K, Suzuki M, Kobayashi S, Hanada K
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Natural ligand-nonmimetic inhibitors of the lipid-transfer protein2019
- Author(s)
  Sakai S, Nakao N, Ueno M, Egawa D, Hanzawa H, Kawasaki S, Kumagai K, Suzuki M, Kobayashi S, Hanada K
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] P1糖鎖エピトープを有した糖タンパク質の志賀毒素受容体としての機能解析2019
- Author(s)
  森本貫太, 鈴木詔子, 花田賢太郎, 鈴木佑典, 山地俊之
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] セラミド輸送タンパク質CERTと細胞内寄生細菌クラミジア封入体膜タンパク質IncDとの会合機序2019
- Author(s)
  花田賢太郎, 熊谷圭悟, 杉木俊彦, 新屋粧子, 小林直宏, 江川大地, 藤原敏道, 児嶋長次郎
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Chlamydia trachomatis requires host ceramide-transport protein CERT but not sphingomyelin synthases for the infection and proliferation in HeLa cells2019
- Author(s)
  Kumagai K, Tachida Y, Sakai S, Yamaji T, Hanada K
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] ヒト肝癌由来Huh7.5.1-8細胞とアフリカミドリザル腎由来Vero細胞におけるフラビウイルス産生の比較解析2019
- Author(s)
  齊藤恭子、深澤征義、白砂圭崇、鈴木亮介、脇田隆字、小西英二、花田賢太郎
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] Chlamydia trachomatis requires host ceramide-transport protein CERT but not sphingomyelin synthases for the infection and proliferation in HeLa cells2019
- Author(s)
  Keigo Kumagai, Yuriko Tachida, Shota Sakai, Toshiyuki Yamaji, Kentaro Hanada,
- Organizer
  9th Chlamydia Basic Research Society(CBRS)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Systematic development of natural ligand-nonmimetic inhibitors to the ceramide transport protein CERT2019
- Author(s)
  Hanada Kentaro
- Organizer
  FEBS special meeting in “Sphingolipid biology in health and disease”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] Delivery of N-cadherin to the surface of neural stem cells is essential for development of the hippocampus and the cerebellum2019
- Author(s)
  Akihiro　Harada
- Organizer
  International Conference of Developmental Biology, Stem Cells and Regenerative Medicine - Exploration and Integration
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] セラミド輸送タンパク質CERTに対する二つのタイプの阻害剤開発2019
- Author(s)
  花田賢太郎
- Organizer
  第92回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Hijacking of the ceramide transport protein CERT by Chlamydia trachomatis, an obligatory intracellular bacterium2019
- Author(s)
  Hanada K
- Organizer
  60th International Conference on the Bioscience of Lipids
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Hijacking of the ceramide transport protein CERT by Chlamydia trachomatis, an obligatory intracellular bacterium2019
- Author(s)
  Hanada Kentaro
- Organizer
  60th International Conference on the Bioscience of Lipids
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] Suppression of transcription factor OASIS ameliorated kidney fibrosis.2019
- Author(s)
  Obana M, Yamamoto A, Nakae T, Miyake Y, Harada T, Mitsuoka S, Noda S, Maeda M, Imaizumi K, Matsumoto K, Fujio Y.
- Organizer
  The American Society of Nephrology (ASN)
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] Structural basis for the specific association between the Chlamydia trachomatis inclusion membrane protein IncD and the PH domain of the ceramide transport protein CERT2019
- Author(s)
  Sugiki T, Kumagai K, Shinya S, Kobayashi N, Egawa D, Fujiwara T, Hanada K, Kojima C
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] The role of SNAP23 in the brain and the pancreas2019
- Author(s)
  Akihiro　Harada
- Organizer
  Gordon conference: molecular membrane biology
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] ゲノムワイドスクリーニングによって同定された糖鎖発現制御因子の解析2019
- Author(s)
  山地俊之, 関塚剛史, 花松久寿, 黒田誠, 古川潤一, 八尋錦之助, 花田賢太郎
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Search for the factors related to HCV replication in the HuH-7 cell line lineages2018
- Author(s)
  Kawamoto M, Endo T, Fukasawa M, Hanada K, Osada N
- Organizer
  SMBE2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] リン酸化によるセラミド輸送蛋白質CERTのPHドメイン機能抑制機序2018
- Author(s)
  江川大地, 杉木俊彦, 熊谷圭悟, 児嶋長次郎, 藤原敏道, 竹内恒, 嶋田一夫, 高橋栄夫, 花田賢太郎
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 天然リガンドと構造類似性のない脂質輸送タンパク質CERTの新規阻害剤2018
- Author(s)
  酒井祥太, 中尾直樹, 上野雅晴, 江川大地, 半沢宏之, 川崎祥平, 熊谷圭吾, 鈴木誠, 小林修, 花田賢太郎
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Establishment of natural ligand-mimetic and nonmimetic inhibitors to the ceramide transport protein CERT2018
- Author(s)
  Kentaro Hanada
- Organizer
  2nd Japan-Korea Lipid Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Chlamydia trachomatisは細胞内寄生に宿主のスフィンゴミエリン生合成を必要としない2018
- Author(s)
  立田由里子, 熊谷圭悟, 酒井祥太, 山地俊之, 花田賢太郎
- Organizer
  第11回セラミド研究会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Chlamydia trachomatisは細胞内寄生に宿主のスフィンゴミエリン生合成を必要としない2018
- Author(s)
  立田由里子, 熊谷圭悟, 酒井祥太, 山地俊之, 花田賢太郎
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Nonvesicular comings and goings of lipids in the Golgi2018
- Author(s)
  Kentaro Hanada
- Organizer
  FEBS 2018 Advanced Course “The 2018 Golgi meeting: Membrane trafficking in cell organization and homeostasis”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Endogenous simian retrovirus variations in Vero cells: implications for quality control of a human vaccine cell substrate2018
- Author(s)
  Sakuma C, Sekizuka T, Kuroda M, Kasai F, Saito K, Ikeda M, Yamaji T, Osada N, Hanada K
- Organizer
  4th International Symposium of Medicinal Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] 宿主細胞のスフィンゴミエリン合成酵素はChlamydia trachomatisの細胞内寄生に必須ではない2018
- Author(s)
  熊谷圭悟, 立田由里子, 酒井祥太, 山地俊之, 花田賢太郎
- Organizer
  第36回日本クラミジア研究会学術集会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] 旧世界ザルゲノムに存在する内在性サルレトロウィルス（SERV）配列の探索と分子系統解析2018
- Author(s)
  池田昌輝, 里村和浩, 関塚剛史, 花田賢太郎, 遠藤俊徳, 長田直樹
- Organizer
  第90回日本遺伝学会
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] 小胞体-ゴルジ体間セラミド輸送を司るCERTの解析とその阻害剤開発2018
- Author(s)
  花田賢太郎
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Endogenous Simian Retrovirus Variations in Vero Cells: Implications for Quality Control of a Human Vaccine Cell Substrate2018
- Author(s)
  Chisato Sakuma, Tsuyoshi Sekizuka, Makoto Kuroda, Fumio Kasai, Kyoko Saito, Masaki Ikeda, Toshiyuki Yamaji, Naoki Osada, Kentaro Hanada
- Organizer
  4th International Symposium for Medicinal Sciences, 2018.3.25-28, Kanazawa
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] セラミド輸送タンパク質CERTにおけるリン酸化を介した機能抑制制御に必要な正電荷リピートを持つcoiled-coilモチーフ2017
- Author(s)
  江川大地, 富重斉生, 山地俊之, 熊谷圭悟, 花田賢太郎
- Organizer
  2017年度生命科学系学会合同年次大会第40回日本分子生物学会年会・第90回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] The molecular mechanism of apical transport in the mouse intestinal epithelial cells: The role of Rabs and their binding proteins2017
- Author(s)
  Akihiro Harada
- Organizer
  EMBO conference ‘Cell polarity and membrane dynamics'
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] Rab11a GTPase regulates apical protein localization and microvilli formation in the intestine2017
- Author(s)
  Sobajima,Tomoaki, Shin-ichiro Yoshimura and Akihiro Harada
- Organizer
  Gordon Research Conference ‘Molecular Membrane Biology’
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] セラミド輸送蛋白質CERTのリン酸化による機能制御の構造生物学的解析： CERT－Golgi体の結合がCERTのリン酸化によって抑制されるメカニズムの溶液NMR法による解明2017
- Author(s)
  杉木俊彦, 江川大地, 熊谷圭悟, 児嶋長次郎, 藤原敏道, 竹内恒, 嶋田一夫, 花田賢太郎, 高橋栄夫
- Organizer
  2017年度生命科学系学会合同年次大会第40回日本分子生物学会年会・第90回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] カルタヘナ法と関わる組換え生物生ワクチン2017
- Author(s)
  花田賢太郎
- Organizer
  バイオロジクスフォーラム第14回学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-15K14993
[Presentation] CRISPRライブラリーを用いた糖脂質生合成に影響を及ぼす因子の探索2017
- Author(s)
  山地俊之,　関塚剛史,佐久間智理,　立田由里子,　黒田誠,　花田賢太郎
- Organizer
  2017年度生命科学系学会合同年次大会第40回日本分子生物学会年会・第90回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] リン酸化によるセラミド輸送蛋白質CERTのPHドメイン機能抑制機序2017
- Author(s)
  江川大地, 杉木俊之, 熊谷圭悟, 児嶋長次郎, 藤原敏道, 竹内恒, 嶋田一夫, 高橋栄夫, 花田賢太郎
- Organizer
  セラミド研究会10周年記念大会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] CERT研究における今までの総括と今後の展望2017
- Author(s)
  花田賢太郎
- Organizer
  第12回スフィンゴテラピー研究会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] Comparative characterization of human hepatoma-derived Huh7.5.1-8 cells and African green monkey kidney-derived Vero cells in Japanese encephalitis virus production ヒト肝癌由来Huh7.5.1-8細胞とアフリカミドリザル腎由来Vero細胞における日本脳炎ウイルス産生の比較解析2017
- Author(s)
  齊藤恭子、深澤征義、白砂圭崇、鈴木亮介、脇田隆字、小西英二、花田賢太郎
- Organizer
  2017年度生命科学系学会合同年次大会（ConBio2017）
- Data Source
  KAKENHI-PROJECT-17H04003
[Presentation] クラミジアのエフェクタータンパク質IncDと宿主細胞由来のセラミド輸送タンパク質CERTのPHドメインとの結合にはIncDのN末領域とC末領域が必要である2017
- Author(s)
  熊谷圭悟, Cherilyn A. Elwell, 安藤秀二、Joanne N. Engel, 花田賢太郎
- Organizer
  2017年度生命科学系学会合同年次大会第40回日本分子生物学会年会・第90回日本生化学会大会
- Data Source
  KAKENHI-PLANNED-17H06417
[Presentation] The role of SNAP23 in secretion2017
- Author(s)
  Masataka Kunii and Akihiro Harada
- Organizer
  Gordon Research Conference ‘Molecular Membrane Biology’
- Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-17H06413
[Presentation] Vero cells: Determination of the genome landscape and its application to QC2016
- Author(s)
  Kentaro Hanada
- Organizer
  Workshop of Western Pacific National Control Laboratories for Vaccines and Blood Products
- Place of Presentation
  韓国ソウル市
- Year and Date
  2016-09-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14993
[Presentation] Vero細胞基材の品質管理に資する基盤研究2016
- Author(s)
  花田賢太郎
- Organizer
  バイオロジクスフォーラム第13回学術集会
- Place of Presentation
  東京
- Year and Date
  2016-02-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K14993
[Presentation] 宿主因子CERTがChlamydia trachomatis感染に果たす役割2015
- Author(s)
  熊谷圭悟、山地俊之、山本章嗣、安藤秀二、花田賢太郎
- Organizer
  第33回クラミジア研究会
- Place of Presentation
  岡山大学鹿田キャンパス
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-25460086
[Presentation] クラミジア・トラコマティスによってハイジャックされる宿主セラミド輸送機構2015
- Author(s)
  熊谷圭悟、山地俊之、山本章嗣、花田賢太郎
- Organizer
  BMB 2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460086
[Presentation] Introductory remarks for the session of Membrane Dynamics and Trafficking2014
- Author(s)
  Kentaro Hanada
- Organizer
  Gordon Research Conference on Glycolipid and Sphingolipid Biology
- Place of Presentation
  Ventura, CA, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] Introductory remarks for the session of Membrane Dynamics and Trafficking2014
- Author(s)
  Kentaro Hanada
- Organizer
  Gordon Research Conference on Glycolipid and Sphingolipid Biology
- Place of Presentation
  Ventura, California, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Introductory remarks for the session of membrane dynamics and Trafficking2014
- Author(s)
  Hanada K
- Organizer
  Gordon Research Conference on Glycolipid and Sphingolipid Biology
- Place of Presentation
  Ventura, CA, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] TALEN-mediated disruption of several sphingolipid-related genes in a HeLa cell line2014
- Author(s)
  Yamaji T, and Hanada K
- Organizer
  Gordon Research Conference on Glycolipid and Sphingolipid Biology
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] TALEN-Mediated Disruption of Several Sphingolipid-Related Genes in a HeLa cell line2014
- Author(s)
  Toshiyuki Yamaji and Kentaro Hanada
- Organizer
  Gordon Research Conference on Glycolipid and Sphingolipid Biology
- Place of Presentation
  Ventura, California, USA
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] TALEN-Mediated Disruption of Several Sphingolipid-Related Genes in a HeLa cell line2014
- Author(s)
  Toshiyuki Yamaji and Kentaro Hanada
- Organizer
  Gordon Research Conference on Glycolipid and Sphingolipid Biology
- Place of Presentation
  Ventura, CA, USA
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] 人工ヌクレアーゼTALENを用いた種々のスフィンゴ脂質関連遺伝子の変異株作製2013
- Author(s)
  山地俊之、花田賢太郎
- Organizer
  第32回日本糖質学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] 人工ヌクレアーゼを利用したゲノム編集技術によるスフィンゴ脂質関連遺伝子破壊HeLa細胞変異株パネル作成の試み2013
- Author(s)
  山地俊之、花田賢太郎
- Organizer
  第８回スフィンゴテラピー研究会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] Structural biology revealed the serendipity of development of HPA-12, a potent inhibitor of intracellular trafficking of ceramide2013
- Author(s)
  Kentaro Hanada
- Organizer
  , FASEB Science Research Conference: Lysophospholipid and other Related Mediators - From Bench to Clinic
- Place of Presentation
  Niseko, Hokkaido, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 遺伝生化学的手法を用いたスフィンゴ糖脂質研究2013
- Author(s)
  山地俊之、花田賢太郎
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 膜接触部位を介した宿主細胞セラミドのクラミジア菌寄生胞・封入体への輸送2013
- Author(s)
  花田賢太郎
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] 細胞内セラミド輸送をつかさどるCERTの発見2013
- Author(s)
  花田賢太郎
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] TALEN-Mediated Disruption of Sphingolipid-Related Genes in a HeLa Cell Line2013
- Author(s)
  Toshiyuki Yamaji and Kentaro Hanada
- Organizer
  54th International Conference on the Bioscience of Lipids: Linking Transcription to Physiology in Lipidomics
- Place of Presentation
  Bari, Italy
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] 遺伝生化学的手法を用いたスフィンゴ糖脂質研究2013
- Author(s)
  山地俊之, 花田賢太郎
- Organizer
  第86回日生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] TALEN-Mediated Disruption of Sphingolipid-Related Genes in a HeLa Cell Line2013
- Author(s)
  Yamaji T, and Hanada K
- Organizer
  54th International Conference on the Bioscience of Lipids : Linking Transcription to Physiology in Lipidomics
- Place of Presentation
  Bari, Italy
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 人工ヌクレアーゼTALENを用いた種々のスフィンゴ脂質関連遺伝子の変異株作製2013
- Author(s)
  山地俊之、花田賢太郎
- Organizer
  第32回日本糖質学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] TALEN-Mediated Disruption of Sphingolipid-Related Genes in a HeLa Cell Line2013
- Author(s)
  Toshiyuki Yamaji and Kentaro Hanada
- Organizer
  54th International Conference on the Bioscience of Lipids: Linking Transcription to Physiology in Lipidomics
- Place of Presentation
  Bari, Italy
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Molecular architecture of CERT for inter-organelle transport of ceramide at the ER-Golgi membrane contact sites2013
- Author(s)
  Kentaro Hanada
- Organizer
  The 14th International Membrane Research Forum
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 細胞内セラミド輸送をつかさどるCERTの発見2013
- Author(s)
  花田賢太郎
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  札幌
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 人工ヌクレアーゼを利用したゲノム編集技術によるスフィンゴ脂質関連遺伝子破壊HeLa細胞変異株パネル作成の試み2013
- Author(s)
  山地俊之、花田賢太郎
- Organizer
  第8回スフィンゴテラピー研究会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 細胞内セラミド輸送をつかさどるCERT の発見2013
- Author(s)
  花田賢太郎
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 人工ヌクレアーゼを用いた種々のスフィンゴ脂質関連遺伝子の変異株作製2013
- Author(s)
  山地俊之, 花田賢太郎
- Organizer
  第55回日本脂質生化学会大会
- Place of Presentation
  松島
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Structural biology revealed the serendipity of development of HPA-12, a potent inhibitor of intracellular trafficking of ceramide2013
- Author(s)
  Kentaro Hanada
- Organizer
  FASEB Science Research Conference: Lysophospholipid and other Related Mediators - From Bench to Clinic
- Place of Presentation
  Niseko, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] 人工ヌクレアーゼTALEN を用いた種々のスフィンゴ脂質関連遺伝子の変異株作製2013
- Author(s)
  山地俊之, 花田賢太郎
- Organizer
  第32回日本糖質学会大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Molecular architecture of CERT for inter-organelle transport of ceramide at the ER-Golgi membrane contact sites2013
- Author(s)
  Hanada K
- Organizer
  The 14th International Membrane Research Forum
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 人工ヌクレアーゼを用いた種々のスフィンゴ脂質関連遺伝子の変異株作製2013
- Author(s)
  山地俊之、花田賢太郎
- Organizer
  第55回日本脂質生化学会大会
- Place of Presentation
  松島
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] 人工ヌクレアーゼを利用したゲノム編集技術によるスフィンゴ脂質関連遺伝子破壊HeLa 細胞変異株パネル作成の試み2013
- Author(s)
  山地俊之,花田賢太郎
- Organizer
  第8回スフィンゴテラピー研究会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 遺伝生化学的手法を用いたスフィンゴ糖脂質研究2013
- Author(s)
  山地俊之、花田賢太郎
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] Introductory remarks for the session of sphingolipid metabolism and Pathology2012
- Author(s)
  Hanada K
- Organizer
  Gordon Research Conference on Glycolipid and Sphingolipid Biology
- Place of Presentation
  Rucca, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Intracellular trafficking of ceramide by the ceramide trafficking protein CERT, Commemorative Symposium on the 20th Anniversary of the Mizutani Foundation for Glycoscience2012
- Author(s)
  Hanada K
- Organizer
  Glycoscience : Diversity and Integration
- Place of Presentation
  Tokyo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] A model of intracellular trafficking of the lipid ceramide2012
- Author(s)
  Hanada K
- Organizer
  2012 American Society of Photobiology
- Place of Presentation
  Montreal, Canada
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Structural basis for the preferential recognition of phosphatidylinositol 4-monophosphate by the pleckstrin homology domain of the ceramide trafficking protein CERT2012
- Author(s)
  Hanada K, Sugiki T, Takeuchi K, Tokunaga, Y, Terasawa, H, Kumagai, K, Yamaji, T, Takahashi, H, Shimada, I
- Organizer
  2012 ASBMB Special Symposium, Frontiers in Lipid Biology
- Place of Presentation
  Banff, Canada
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Structural basis for the recognition of phosphatidylinositol 4-monomphosphate by the pleckstrin homology domain of the ceramide trafficking protein CERT2012
- Author(s)
  Kentaro Hanada
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Structural basis for the recognition of phosphatidylinositol 4-monophosphate by the pleckstrin homology domain of the ceramide trafficking protein CERT2012
- Author(s)
  Kentaro Hanada, Toshihiko Sugiki, Koh Takeuchi, Yuji Tokunaga, Hiroaki Terasawa, Keigo Kumagai, Toshiyuki Yamaji, Hideo Takahashi, and Ichio Shimada
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Structural basis for the preferential recognition of phosphatidylinositol 4-monomphosphate by the pleckstrin homology domain of the ceramide trafficking protein CERT2012
- Author(s)
  Kentaro Hanada
- Organizer
  2012 ASBMB Special Symposium, Frontiers in Lipid Biology
- Place of Presentation
  Banff, Canada
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 膜接触部位を介した宿主細胞セラミドのクラミジア菌寄生胞・封入体への輸送2012
- Author(s)
  花田賢太郎
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] セラミド輸送タンパク質CERT とVAP との相互作用制御2012
- Author(s)
  熊谷圭悟, 花田賢太郎
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] クラミジア菌の宿主細胞内増殖にセラミド輸送タンパク質CERTは重要である2012
- Author(s)
  花田賢太郎
- Organizer
  第54回日本脂質生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Co-evolution of SM and CERT: Diverse lipids may require co-evolution of enzymes and trafficking system2012
- Author(s)
  Kentaro Hanada
- Organizer
  Riken Symposium, Evolution of Lipids
- Place of Presentation
  埼玉県和光市
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 日本におけるワクチン国家検定制度2012
- Author(s)
  花田賢太郎
- Organizer
  バイオロジクスフォーラム第9回学術集会
- Place of Presentation
  東京
- Year and Date
  2012-02-22
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Intracellular trafficking of ceramide by the ceramide trafficking protein CERT2012
- Author(s)
  Kentaro Hanada
- Organizer
  Commemorative Symposium on the 20th Anniversary of the Mizutani Foundation for Glycoscience, Glycoscience: Diversity and Integration
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] セラミド輸送タンパク質CERTの分子解析2012
- Author(s)
  花田賢太郎
- Organizer
  セラミド研究会第5回学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Co-evolution of SM and CERT : Diverse lipids may require co-evolution of enzymes and trafficking system2012
- Author(s)
  Hanada K
- Organizer
  Riken Symposium, Evolution of Lipids
- Place of Presentation
  Saitama, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] セラミド輸送タンパク質CERT の分子解析2012
- Author(s)
  花田賢太郎
- Organizer
  第5回セラミド研究会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] セラミド輸送タンパク質CERTのプレクストリン相同ドメインによるホスファチジルイノシトール4-リン酸認識の構造基盤2012
- Author(s)
  花田賢太郎
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-23790118
[Presentation] 哺乳動物細胞における膜脂質選別輸送2012
- Author(s)
  花田賢太郎
- Organizer
  理化学研究所・基幹研究所・細胞システムコロキウムシリーズIII 膜から探る生命秩序
- Place of Presentation
  埼玉
- Year and Date
  2012-01-25
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] ジョアン・エンゲル : クラミジア菌の宿主細胞内増殖にセラミド輸送タンパク質CERTは重要である2012
- Author(s)
  花田賢太郎
- Organizer
  第54回日本脂質生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] 抗がん性リモノイドはCERT による小胞体からのセラミドの引き抜きを阻害することによりスフィンゴミエリン合成を阻害する2011
- Author(s)
  Francoise Hullin-Matsuda,冨重斉生,牧野麻美,石塚玲子,石井久美子,Elad Lavee Laviad,Anthony Futerman,Michel Lagarde, Hubert Vidal,花田賢太郎,小林俊秀
- Organizer
  第6回スフィンゴテラピー研究会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Intracellular trafficking of ceramide by the ceramide transfer protein CERT2011
- Author(s)
  Hanada K
- Organizer
  The Annual Fall Scientific Conference of the Korean Society of Lipidology and Atherosclerosis
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Intracellular trafficking of ceramide by the ceramide transfer protein CERT2011
- Author(s)
  Kentaro Hanada
- Organizer
  The Annual Fall Scientific Conference of the Korean Society of Lipidology and Atherosclerosis
- Place of Presentation
  韓国ソウル市(招待講演)
- Year and Date
  2011-09-02
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Crystal structures of the CERT START domain in complex with lipid substrates and specific inhibitors provide insights into the molecular mechanisms of ceramide transfer2010
- Author(s)
  Kudo N, Kumagai K, Matsubara R, Kobayashi S, Wakatsuki S, Hanada, K, and Kato, R
- Organizer
  The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Globotriaosylceramide (Gb3) is reduced by the expression of hydrophobic polypeptides including TMBIM family : Isolation of Shiga toxin-resistant genes2010
- Author(s)
  Yamaji T, Nishikawa T, and Hanada K
- Organizer
  The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] CERT-dependent trafficking of ceramide2010
- Author(s)
  Kentaro Hanada
- Organizer
  The 27^<th> Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo, Hokkaido, Japan
- Year and Date
  2010-06-30
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] CERT-dependent trafficking of ceramide2010
- Author(s)
  Hanada K
- Organizer
  The 27th Naito Conference on Membrane Dynamics and Lipid Biology [I]
- Place of Presentation
  Sapporo
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] Regulation of CERT-mediated trafficking of ceramide2009
- Author(s)
  K. Hanada
- Organizer
  4th International Conference on Phospholipase A2 and Lipid Mediators (PLM2009)
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of intracellular trafficking of ceramide by phosphorylayion of CERT2009
- Author(s)
  K. Hanada
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of CERT-mediated trafficking of ceramide2009
- Author(s)
  K. Hanada
- Organizer
  4^<th> International Conference on Phospholipase A2 and Lipid Mediators (PLM2009)
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of CERT-mediated trafficking of ceramide2009
- Author(s)
  K. Hanada
- Organizer
  20th International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2009-06-22
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of CERT-mediated trafficking of ceramide2009
- Author(s)
  Kentaro Hanada
- Organizer
  4^<th> International Conference on Phospholipase A2 and Lipid Mediators(PLM2009)
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Critical roles of virion-associated cholesterol and sphingolipids in the viral infectivity2008
- Author(s)
  H Aizaki, 他4名, K Hanada, Y Matsuura, M Lai, T Miyamura, T Wakita, T Suzuki
- Organizer
  XIVth International Congress of Virology
- Place of Presentation
  Istanbul, Turkey
- Year and Date
  2008-08-15
- Data Source
  KAKENHI-PROJECT-19041074
[Presentation] セラミドの細胞内選別輸送2008
- Author(s)
  花田賢太郎
- Organizer
  第19回フォーラム・イン・ドージン
- Place of Presentation
  熊本
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] 脂質のC型肝炎ウイルス感染における役割2008
- Author(s)
  相崎英樹, 他7名、花田賢太郎、宮村達男、脇田隆字、鈴木哲朗
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19041074
[Presentation] Regulation of CERT-mediated trafficking of ceramide2007
- Author(s)
  K. Hanada
- Organizer
  48^<th> International Conference on the Bioscience of Lipids
- Place of Presentation
  Turku, Finland
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of CERT-mediated trafficking of ceramide2007
- Author(s)
  K. Hanada
- Organizer
  48th International Conference on the Bioscience of Lipids
- Place of Presentation
  Turku, Finland.
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of CERT-mediated trafficking of ceramide2007
- Author(s)
  Kentaro Hanada
- Organizer
  48^<th> International Conference on the Bioscience of Lipids
- Place of Presentation
  フィンランド
- Year and Date
  2007-09-07
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] CERT and ceramide trafficking2007
- Author(s)
  K. Hanada
- Organizer
  Japan-Switzerland 2nd Joint Seminar on synthesis and trafficking of glycolipids and glycolipid anchored proteins
- Place of Presentation
  Tsukuba, Japan.
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of intracellular trafficking of ceramide, FEBS special meeting2006
- Author(s)
  K. Hanada
- Organizer
  New concepts in lipidology : from lipidomics to disease
- Place of Presentation
  Noordwijkerhout, The Netherlands
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of intracellular trafficking of ceramide2006
- Author(s)
  K. Hanada
- Organizer
  FEBS special meeting, New concepts in lipidology: from lipidomics to disease
- Place of Presentation
  Noordwijkerhout, The Netherlands.
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] Regulation of CERT-mediated trafficking of ceramide2006
- Author(s)
  K. Hanada
- Organizer
  20^<th> International Congress of Biochemistry and Molecular Biology
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2006-06-22
- Data Source
  KAKENHI-PROJECT-18370049
[Presentation] CERT-VAP間の相互作用調節を介したセラミド輸送の制御
- Author(s)
  花田賢太郎、熊谷圭悟
- Organizer
  第9回スフィンゴテラピー研究会
- Place of Presentation
  加賀市
- Year and Date
  2014-07-18 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] Phosphoregulation of inter-organelle traffic of ceramide in mammalian cells
- Author(s)
  Kentaro Hanada
- Organizer
  The International Conference of the Korean Society for Molecular and Cellular Biology (KSMCB)
- Place of Presentation
  韓国ソウル市
- Year and Date
  2014-10-21 – 2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] アフリカミドリザル腎由来Vero細胞のゲノム構造決定
- Author(s)
  花田賢太郎、山地俊之、黒田誠、関塚剛史、小原有弘、笠井文生、平山知子、長田直樹
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都市
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] Structural biology revealed the serendipity of development of HPA-12, a potent inhibitor of intracellular trafficking of ceramide
- Author(s)
  Hanada K
- Organizer
  FASEB Science Research Conference : Lysophospholipid and other Related Mediators - From Bench to Clinic
- Place of Presentation
  Niseko, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22370054
[Presentation] セラミド輸送タンパク質CERTのリン酸化による機能制御
- Author(s)
  熊谷圭悟、花田賢太郎
- Organizer
  第56回日本脂質生化学会大会
- Place of Presentation
  東大阪市
- Year and Date
  2015-06-06 – 2015-06-07
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] CERT-VAP間の相互作用調節を介したセラミド輸送の制御
- Author(s)
  花田賢太郎，熊谷圭悟
- Organizer
  第9回スフィンゴテラピー研究会
- Place of Presentation
  Seoul
- Year and Date
  2014-07-18 – 2014-07-19
- Data Source
  KAKENHI-PROJECT-25460086
[Presentation] セラミドの構造多様性について
- Author(s)
  花田賢太郎
- Organizer
  スフィンゴ脂質データベースワークショップ
- Place of Presentation
  三島市
- Year and Date
  2014-05-22 – 2014-05-23
- Invited
- Data Source
  KAKENHI-PROJECT-25670065
[Presentation] セラミド輸送タンパク質CERTのPHドメインによるPI4P認識の構造基盤
- Author(s)
  花田賢太郎
- Organizer
  第85回　日本生化学大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23790118
[Presentation] Phosphoregulation of inter-organelle traffic of ceramide in mammalian cells
- Author(s)
  Kentaro Hanada
- Organizer
  The International Conference of the Korean Society for Molecular and Cellular Biology
- Place of Presentation
  Seoul
- Year and Date
  2014-10-21 – 2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-25460086
[Presentation] CERT-VAP間の相互作用調節を介したセラミド輸送の制御
- Author(s)
  熊谷圭悟，花田賢太郎
- Organizer
  第56回脂質生化学会
- Place of Presentation
  大阪府
- Year and Date
  2014-06-06 – 2014-06-07
- Data Source
  KAKENHI-PROJECT-25460086

1. SAITO Kyoko (70235034)

# of Collaborated Projects: 6 results

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2. KUMAGAI Keigo (40443105)

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# of Collaborated Products: 33 results
3. NISHIJIMA Masahiro (60072956)

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4. FUKASAWA Masayoshi (20291130)

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5. YAMAJI Toshiyuki (50332309)

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6. WAKITA Taksji (40280789)

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7. AIZAKI Hideki (00333360)

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8. KAWASAKI Kiyosi (60270641)

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9. KUGE Osamu (30177977)

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10. SAKUMA Chisato (80782888)

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11. 加藤薫 (80356782)

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12. 桶本優子 (30392319)

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13. TOMISHIGE Nario (10435711)

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14. KAWANO Miyuki (10454498)

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15. SUGIKI Toshihiko (70635698)

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16. OHGA Youko (50178000)

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17. Shimizu Shigeomi (70271020)

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18. 三田村俊秀 (80268846)

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19. 田井久美子 (00187907)

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# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 原田彰宏 (40251441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
23. 黒川量雄 (40333504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
24. 後藤聡 (60280575)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 齊藤達哉 (60456936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 森和俊 (70182194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 中野明彦 (90142140)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 今泉和則 (90332767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
29. KASAI Fumio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. OSADA Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. ARITA Minetaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 齋藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
33. 上野雅晴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 森嘉生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 吉村信一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 佐藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 橋本唯史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 舟本聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 松本真司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HANADA Kentaro 花田 賢太郎

Research Projects

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Construction of a Vero cell system that will serve as the basis for coronavirus research and vaccine developmentPrincipal Investigator

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Lipid transport via the endoplasmic reticulum communication zonesPrincipal Investigator

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Construction of improved virus-susceptible host cells by genome editingPrincipal Investigator

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Genomics-based improvement of Vero cells for virus growthPrincipal Investigator

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Molecular strategy for the prevention of Chlamydia hijacking of a host lipid transport systemPrincipal Investigator

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Regulatory mechanism of intracellular trafficking of ceramidePrincipal Investigator

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Determination of phosphorylation sites of the ceramide transport protein CERT, and a role of the phosphorylationPrincipal Investigator

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細胞内スフィンゴ脂質選別輸送の分子機構と生体膜ドメイン形成にはたす役割Principal Investigator

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HANADA Kentaro 花田賢太郎