NAKANISHI Toru 中西徹

Researcher Number	30243463
External Links
Affiliation (based on the past Project Information) *help	2004 – 2023: 就実大学, 薬学部, 教授 2001 – 2003: Okayama University, Graduate School of Medicine and Dentistry, Associate Professor, 大学院・医歯学総合研究科, 助教授 1998 – 2000: 岡山大学, 歯学部, 助教授 1992 – 1997: 岡山大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Functional basic dentistry / Biological pharmacy / Drug development chemistry / Basic Section 50020:Tumor diagnostics and therapeutics-related / Functional basic dentistry Except Principal Investigator Functional basic dentistry / 補綴理工系歯学 / Morphological basic dentistry / Morphological basic dentistry / Surgical dentistry … More / General surgery / Basic Section 56020:Orthopedics-related / Orthopaedic surgery / Social dentistry / 補綴理工系歯学 / Functional basic dentistry / Prosthetic dentistry / Biological pharmacy Less
Keywords	Principal Investigator CD81 / テトラスパニン / 骨芽細胞 / 関節リウマチ / シノビオリン / DNAチップ / 軟骨細胞 / 遺伝子治療 / caspase / ATDC5 … More / MAP kinase / crosslink / CTGF / MAPキナーゼ / differential display / アポトーシス / 炎症性サイトカイン / モノクローナル抗体 / siRNA / 滑膜細胞 / 脂肪細胞 / テロメラーゼ / trk / PCR / ニューロトロフィン / 神経成長因子 / 骨肉腫 / 乳がん / エクソソーム / 免疫染色 / 定量PCR / 頭頚部がん / 間接リウマチ / 遺伝子クローニング / キメラ抗体 / adipocytes / osteoblasts / DNA methylation / DNA chips / telomerase / stem cells / DNAメチル化 / 幹細胞 / transgenic mice / rheumatoid arthritis / osteosrthritis / chemokine / microarray / HSP47 / DNA発現アレイ / caspase-9 / トランスジェニックマウス / 慢性関節リウマチ / 変形性関節症 / ケモカイン / マイクロアレイ / tyrosine kinase / integrin / proteoglycan / affinity chromatography / connective tissue growth factor (CTGF) / FGF / PDGF / Scatchard解析 / 結合組織増殖因子(CTGF) / ペプチドマッピング / 内軟骨性骨化 / レセプター / チロシンキナーゼ / インテグリン / プロテオグリカン / アフィニティークロマト / クロスリンク / 結合組織成長因子(CTGF) / 炎症生サイトカイン / ELISA / iPS細胞 / グリア細胞 / TNFalpha / サンドイッチELISA / リウマチ / 再生治療 / 再生医療 / 発現プロファイル / 間葉系幹細胞 / 遺伝子発現 / PC12 … More Except Principal Investigator CTGF / 軟骨細胞 / 遺伝子発現 / 骨芽細胞 / 結合組織成長因子 / アデノウイルスベクター / 細胞分化 / ELISA / chondrocyte / gene expression / 内軟骨性骨化 / CCN / 細胞増殖 / エコジェニン / 軟骨 / 再生 / 骨髄間葉系幹細胞 / マウス / チタン / 骨 / connective tissue growth factor (CTGF) / chondrocytes / 血管内皮細胞 / 遺伝子導入 / CD81 / 骨肉腫 / sod-1 / xab-2 / HGF / 間葉系幹細胞 / 硬組織 / CCN2 / signal transduction / ccn2 / callus / regeneration / カルス / 骨折 / ErbB4 / bone regeneration / bone marrow cells / オッセオインテグレーション / 骨再生 / 分子標的治療 / mutant animal / cbfal / mouse / 発生 / トランスジェニックマウス / Hcs24 / アポトーシス / CCNファミリー / Titanium / MC3T3-E1 cell / connective tissue growth factor / アデノウイルス / angiogenesis / 血管新生 / ecogenin / 情報伝達 / 受容体 / bone metastasis / metastasis / 骨転移 / trk / 血管 / differentiation / endothelial cells / osteoblasts / endochondral ossification / HCS-2 / 結合組織増殖因子(CTGF) / RNase Protection Assay / RT-PCR / Cell differentiation / Chondrocyte / ニューロトロフィン / 遺伝子クローニング / 口腔癌 / ラット / 歯 / タンパク質 / シグナル伝達 / 骨折治癒 / 低酸素 / シスエレメント / 結合組織成長因子(CTGF) / MC3T3-E1細胞 / CTGF遺伝子 / 分化 / 増殖 / 遺伝子治療 / 分子標的薬 / エクソソーム / テトラスパニン / テトラスパニンファミリー / 骨肉腫制御 / 分子標的治療薬 / chemotaxis / hypertrophic chondrocyte / apoptosis / osteoclast / CTGFノックアウトマウス / 肥大軟骨細胞 / c-Met / SF / 肥大軟骨 / 破骨細胞 / proteomics / medicine / saliva / protein / eldery people / 2 dimension electrophoresis / diagnosis / dry mouth / プロテオミクス / 薬剤 / 唾液 / 高齢者 / 2次元電気泳動 / 診断 / 口腔乾燥 / galection-1 / Osseointegration / Osteoblasts / 幹葉系幹細胞 / 骨組織再生 / チタン特異的遺伝子 / デンタルインプラント / galectin-1 / 培養骨芽細胞 / restitutive medicine / stem cells / notch / 幹細胞 / Notch / mouse embryonic stem cells / lentiviral vector / adipocyte / osteocyte / human bone marrow mesenchymal stem cells / マウスES細胞 / レンチウイルスベクター / 脂肪細胞 / 骨細胞 / ヒト骨髄間葉系幹細胞 / regulation of gene expression / binding molecule / hard tissue / regenerin / ゼラチンハイドロゲル / CTGF遺伝子ノックアウトマウス / CCN22 / 結合蛋白 / 歯根膜 / 遺伝子変異動物 / 遺伝子発現制御 / 結合分子 / リジェネリン / module / モジュール / rat / bone fracture / hydroxyapatito / βTCPフォーム / 生体親和性材料 / bFGF / 生態親和性材料 / 歯周組織・歯槽骨再生 / ハイドロキシアパタイト / 骨髄幹細胞 / molecular target therapy / bone destruction / bone invasion / hypercalcemia / osteoclastic bone resorption / アンチセンス / 骨破壊 / 骨浸潤 / 高カルシウム血症 / 破骨細胞性骨吸収 / development / tooth / hone / cartilage / パールカン / アクチン / 成長 / cbfa1 / 変異動物 / checkpoint / M phase / cell cycle / チェックポイント / M期 / 細胞周期 / dwarfism / transgenic mouse / Cbfa1 / 骨粗鬆 / Adenovirus / Gene therapy / Articular cartilage / Mechanical stress / Osteoarthritis / 培養軟骨細胞 / 組織変化 / 動物モデル / マトリックスメタロプロテアーゼ / 一酸化窒素 / 軟骨破壊 / 関節軟骨 / メカニカルストレス / 変形性顎関節症 / hypoxia / angiogenesis(diseases) / CCN family / 血管新生(病) / Ex vivo gene delivery / Tooth extraction socket / Adenovirus vector / TGF-β遺伝子 / BMP遺伝子 / 抜歯創時癒過程 / MC3T3-El cell / ex vivo遺伝子導入法 / 抜歯創 / odontoblast / transforming growth factor-beta / adenovirus vector / gene transfection / reparative dentin / クローニング / 炎症 / 象牙芽細胞 / β型形質転換増殖因子 / 修復象牙質 / cis-element / untranslated region / 非翻訳領域 / myocardial infarction / neovascularization / rheumatoid arthritis / anti-CTGF antibody / 抗CTGF抗体 / 心筋梗塞 / 慢性関節リウマチ / 転移 / 抗CTGF / phosphorylation / receptor / matricrine / proliferation / growth factor / ELK / MAPK / リン酸化 / マトリクリン / molecular cloning / oral squamous cell carcinoma / molecular mechanism / bone formation / bone resorption / metastatic marker / 転移性御意電子 / 心腔齲内注射 / Differental Display / 骨形成型骨転移 / 骨吸収型骨転移 / 心腔内注射 / 転移因子 / 臓器特異性 / 口腔扁平上皮癌 / osteo (chondro) neurotrophin / neurotrophin / blood vessel / nerve / cargilage / bone / 8 / 神経栄養因子 / コンドロニューロトロフィン / オステオ(コンドロ)ニューロトロフィン / 神経 / growth / アンチセンスオリゴマー / 神経細胞 / リコンビナントCTGF / レセプター / 8細胞 / Transcriptional promoter / Chondrocytes / Chondrosarcoma / Osteoblastic cell / Insulin-like growth factor I / Insulin-like growth factor II / Insulin-like growth factor-I / 転写調節 / 軟骨様細胞 / Insulim-like growth factor-I / Insulin-like growth factor-II / 転写プロモーター / 軟骨肉腫 / Insulin-like growth factor-l / Insulin-like growth factor-ll / Proliferation / Chondrosarcoma cell line / Connective tissue growth factor / Molecular cloning / Differential-display / Cartilage-specific gene / 分化マーカー / 軟骨細胞株 / 軟骨肉腫細胞株 / 結合組織増殖因子 / ディフェレンシャル・ディスプレイ / 軟骨特異的遺伝子 / Neuron associated bone / Epitheliomesenchymal interaction / differentiation factor / Growth / Homeobox gene / Positional information / Morphogen / Limb bud / Morphogenesis / 共唯点レ-ザ-顕微鏡 / レチノイン酸レセプタ- / レチノイン酸 / 共焦点レ-ザ-顕微鏡 / p53癌抑制遺伝子 / 増殖因子 / 腫瘍侵潤 / 血管新生抑制 / 骨吸収 / 無蛋白培地 / 扁平上皮癌 / ペプチド成長因子 / 骨誘導因子 / 位置価 / 共焦点レーザー顕微鏡 / in situ hybridization / 骨形成 / 神経投射組織 / 上皮間充織相互作用 / 成長分化因子 / ホメオボックス遺伝子 / 位置情報 / モルフォジェン / 肢芽 / 形態形成 / マイクロアレイ / DNAアレイ / 遺伝子 / 認知症 / 海馬 / 記憶 / 咀嚼 / 蛋白質 / 構造生物学 / 関節リウマチ / 構造解析 / アメリカ / 国際情報交換 / バイオテクノロジー / 移植・再生医療 / 再生医学 / 細胞・組織 / ヒトES細胞 / 人工臓器学 / MMPs / 組み換え体タンパク質 / MC3T3E1細胞 / LacZ遺伝子 / ポリ乳酸 / アテロコラーゲン / TGF-β / 歯周組織 / 歯根膜線維芽細胞 / インスリン様成長因子 / トランスフォーミング増殖因子 / 関節 / 顎関節 / 二成分制御系 / 転写制御 / narオペロン / 硝酸還元酵素 / 嫌気呼吸系 / FNR / NarL / DNA結合蛋白質 Less

Development of CD81 Antibody Therapy for Osteosarcoma - Focused on Exosomes -
- Principal Investigator
  
  白井寿治
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Kyoto Prefectural University of Medicine
Development of anti-tumor drugs targeting CD81Principal Investigator
- Principal Investigator
  
  Nakanishi Tohru
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shujitsu University
Development of novel gene therapy for rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Nakanishi Tohru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Shujitsu University
Development of novel anti-cancer drug targeting CD81 of osteosarcoma
- Principal Investigator
  
  Shirai Toshiharu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto Prefectural University of Medicine
Development of novel therapeutic compounds for rheumatoid arthritis targeting CD81Principal Investigator
- Principal Investigator
  
  Nakanishi Tohru
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Shujitsu University
Development of novel antibody therapy targeting tetraspanin CD81Principal Investigator
- Principal Investigator
  
  NAKANISHI Tohru
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Shujitsu University
Prevention of dementia by the recovery of the mastication
- Principal Investigator
  
  HARA Tetsuya
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Prosthetic dentistry
- Research Institution
  Okayama University
Isolation and identification of CD81 as a novel target for treatment of rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  中西徹
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Shujitsu University
Hepatic differentiation of human embryonic stem cells and its application to the development of a bioartificial liver system
- Principal Investigator
  
  TANAKA Noriaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Okayama University
Structure-activity relationship of intercecullar signaling factor CCN family proteins and their application to drug deve lopment
- Principal Investigator
  
  MORI Hiroki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Shujitsu University
Analysis of stem-cell differentiation mechanism by using DNA microarray and novel bisulfite modification.Principal Investigator
- Principal Investigator
  
  NAKANISHI Tohru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Shujitsu University
Expression of connective tissue growth factor CTGF in the callus during bone regeneration and application for acceleration of regeneration.
- Principal Investigator
  
  YAMAAI Yuichiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Okayama University
Possibility of proteomic analyzation of saliva from patients with dry mouth
- Principal Investigator
  
  KISHIMOTO Etsuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Social dentistry
- Research Institution
  Okayama University
間葉系幹細胞の遺伝子発現プロファイル解析と硬組織再生への応用Principal Investigator
- Principal Investigator
  
  OHYAMA Kazumi, 中西徹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Development of Regenerative Medicine Using Reversibly Proliferating Human Bone Marrow Mesenchymal Stem Cells
- Principal Investigator
  
  TANAKA Noriaki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  OKAYAMA UNIVERSITY
Application of the CCN gene family to the regulation of osteogenic stem cells and restitutive medicine
- Principal Investigator
  
  KATSUBE Ken-ichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo Medical and Dental University
Cloning, Expression and Identification of Specific Genes related Osseointegration to Titanium.
- Principal Investigator
  
  KANYAMA Manabu
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  OKAYAMA UNIVERSITY
Establishment of a autologous cell transplantion method using mesenchymal stem cells for perio-dontal tissue and alveolus bone regeneration.
- Principal Investigator
  
  KUBOKI Takuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  OKAYAMA UNIVERSITY
The role of cells expressing connective tissue growth factor CTGF and ErbB4 receptor during regeneration and/or skeletomuscular development
- Principal Investigator
  
  YAMAAI Yuichiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  OKAYAMA UNIVERSITY
Functional dissection and medical application of the 4 modules in the chondrocyte-derived growth factor, ecogenin/CTGF.
- Principal Investigator
  
  KUBOTA Satoshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  OKAYAMA UNIVERSITY
軟骨成長因子エコジェニン/CTGFによる生体デザインを目指す研究
- Principal Investigator
  
  滝川正春
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Functional analysis of the cartilage-derived multifunctional growth factor ecogenin/CTGF by using mutant animals
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Investigation of mechanism of connective tissue growth factor (CTGF) as a molecular target against cancer-induced bone destruction
- Principal Investigator
  
  SASAKI Akira
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
Molecular cloning of the factors that biologically accelerate reparative dentin formation
- Principal Investigator
  
  KUBOKI Takuo
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  Okayama University
Ex Vivo Gene Delivery Using an Adenovirus Vector in Treatment for Dental Implant
- Principal Investigator
  
  KANYAMA Manabu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  OKAYAMA UNIVERSITY
Development of analytical method for each domain of CTGF/ecogenin and its clinical application.
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  OKAYAMA UNIVERSITY
Gene therapy for temporomandibular joint osteoarthritis
- Principal Investigator
  
  KUBOKI Takuo
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  補綴理工系歯学
- Research Institution
  OKAYAMA UNIVERSITY
Analysis on the gene expression of CTGF, an endochondral ossification factor, during mouse development and its application for a bone regeneration
- Principal Investigator
  
  YAMAAI Yuichiro
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  OKAYAMA UNIVERSITY
Analysis of gene expression in chondrocytes using DNA microarrays (DNA chips)Principal Investigator
- Principal Investigator
  
  NAKANISHI Tohru
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  OKAYAMA UNIVERSITY
Investigation of the intracellular function of human ecogenin/CTGF, a chondrocyte-derived growth factor.
- Principal Investigator
  
  KUBOTA Satoshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  OKAYAMA UNIVERSITY
軟骨由来成長因子エコジェニン/CTGFを用いた歯周組織再建への試み
- Principal Investigator
  
  滝川正春
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
アデノウイルスベクター法を用いた早期osseointegrationの獲得
- Principal Investigator
  
  KANYAMA Manabu (完山学)
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  補綴理工系歯学
- Research Institution
  Okayama University
Investigation of the regulatory mechanism of gene expression of human ecogenin/CTGF, a chondrocyte-derived growth factor.
- Principal Investigator
  
  OHYAMA Kazumi, 服部高子
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Studies on the mechanism of actions of a cartilage-derived pleiotrophic growth factor, ecogenin/CTGF - Molecular cloning of its receptors and mechanism of inter- and intra signal transduction -
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Development of inhibitors for a angiogenesis factor CTGF and its application for angiogenetic diseases
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
アデノウイルスベクターを用いた遺伝子導入法による顎関節症の遺伝子治療の試み
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
INVESTIGATION OF MECHANISM OF BONE METTASTASIS AND MOLECULAR CLONING OF BONE METASITASIS RELATED GENE
- Principal Investigator
  
  MATSUMURA Tomohiro
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  OKAYAMA UNIVERSITY
Molecular cloning of the receptors for chondrosarcoma-derived chondrocyte growth factor Ecogenin/CTGFPrincipal Investigator
- Principal Investigator
  
  NAKANISHI Tohru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
The role of hcs-24, a newly isolated hypertrophic chondrocyte-specific gene, in endochondral ossification
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Molecular cloning of novel osteoneurotrophins and their application as therapeutic agents for bone and cartilage diseases
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
歯牙および骨組織における神経機能の分子生物学的解析Principal Investigator
- Principal Investigator
  
  中西徹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Cloning and functional analysis of novel genes related to chondrocyte differentiation using the human chondrocytic cell lines
- Principal Investigator
  
  TAKIGAWA Masaharu
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
Expression and promoter-alternation of osteoblastic insulin-like growth factors
- Principal Investigator
  
  TAKAHASHI Kojiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
歯牙および骨組織における神経機能の分子生物学的解析Principal Investigator
- Principal Investigator
  
  中西徹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
二制御因子(NarL・FNR)系によるnarオペロンの協同的転写制御
- Principal Investigator
  
  TAKAHASHI Kojiro
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okayama University
Three-dimensional molecular status of bone morphogenesis as revealed from molecular biological analyzes.
- Principal Investigator
  
  TANIGUCHI Shigehiko, 榎本昭二
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Okayama University
  Tokyo Medical and Dental University

[Book] 遺伝子工学-基礎から医療まで-2017
- Author(s)
  根岸和雄、中西　徹
- Total Pages
  266
- Publisher
  廣川書店
- ISBN
  9784567450201
- Data Source
  KAKENHI-PROJECT-17K08379
[Book] 別冊BIO Clinica　慢性炎症と疾患2016
- Author(s)
  中西　徹、山崎　勤、新井祐志、中川周士、久保俊一
- Total Pages
  168
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-26460165
[Book] 新・分子骨代謝学と骨粗鬆症(松本俊夫編:メディカルレビュー社)2001
- Author(s)
  中西徹、滝川正春
- Publisher
  軟骨細胞の分化制御と軟骨形成
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13307053
[Journal Article] Construction of an expression vector containing mouse-rat chimeric genes encoding a therapeutic antibody against CD812019
- Author(s)
  Yamasaki T, Arai Y, Nakagawa S, Kubo T, Nakanishi T
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 28 Pages: 239-244
- NAID
  130007685302
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08379
[Journal Article] The tetraspanin CD81 mediates the growth and metastasis of human osteosarcoma2019
- Author(s)
  Mizoshiri N, Shirai T, Terauchi R, Tsuchida S, Mori Y, Hayashi D, Kishida T, Arai Y, Nakanishi T, Kubo T
- Journal Title
  
  Cell Oncol
  
  Volume: on line
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08379
[Journal Article] Construction of an Expression Vector Containing Mouse-Rat Chimeric Genes Encoding a Therapeutic Antibody against CD812019
- Author(s)
  Tsutomu Yamasaki, Yuji Arai, Shuji Nakagawa, Toshikazu Kubo and Tohru Nakanishi
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: in press
- NAID
  130007685302
- Data Source
  KAKENHI-PROJECT-17K08379
[Journal Article] 関節リウマチの診断法について2018
- Author(s)
  山崎　勤、中西　徹
- Journal Title
  
  就実大学薬学雑誌
  
  Volume: 5 Pages: 1-8
- NAID
  120006535135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08379
[Journal Article] Identification of specific protein markers of rheumatoid arthritis in synovial fluid and serum.2017
- Author(s)
  Mihara K, Kohno S, Hatanaka S, Yamasaki T, Nishida K and Nakanishi T
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 27 Pages: 55-58
- NAID
  130006301942
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08379
[Journal Article] テトラスパニンCD81を標的とする新規次世代リウマチ治療薬の開発2016
- Author(s)
  中西　徹、山崎　勤、新井祐志、中川周士、久保俊一
- Journal Title
  
  アレルギーの臨床
  
  Volume: 36 Pages: 1382-1387
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460165
[Journal Article] CD81 mediated regulation of synoviolin expression in synovial sarcoma cells.2016
- Author(s)
  Fujimoto E, Matsushita U, Nakajima T, Yagishita N, Yamasaki T. Nakanishi T
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 25 Pages: 377-382
- NAID
  130005249136
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460165
[Journal Article] Establishment of sandwich enzyme-linked immunosorbent assay (ELISA) system for quantitation of CD81.2015
- Author(s)
  Hatanaka S, Mihara H, Kohno S, Fujimoto E, Tanaka M, Takehara M. Nakanishi T.
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 24 Pages: 401-404
- NAID
  130005104333
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460165
[Journal Article] Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro.2014
- Author(s)
  2)Fujita H, Yamamoto M, Ogino T, Kobuchi H, Ohmoto N, Aoyama E, Oka T, Nakanishi T, Inoue K, Sasaki
- Journal Title
  
  Cell Biochem Funct
  
  Volume: 32 Pages: 77-86
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460165
[Journal Article] Establishment of a monoclonal antibody against CD81 that decreases the proliferation of rat glioma cells.2014
- Author(s)
  Fujimoto E, Mori H, Takehara M, Tanaka M, Ohashi T, Ninomiya Y, Nakanishi T.
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 23 Pages: 131-134
- NAID
  130004480632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro2014
- Author(s)
  Fujita H, Yamamoto M, Ogino T, Kubochi H, Ohmoto N, Aoyama E, Oka T, Nakanishi T, Inoue K, Sasaki J
- Journal Title
  
  Cell Biochem Funct
  
  Volume: 32 Pages: 77-8
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Establishment of a monoclonal antibody against CD81 that decreases the proliferation of rat glioma cells.2014
- Author(s)
  1)Fujimoto E, Mori H, Takehara M, Tanaka M, Ohashi T, Ninomiya Y, Nakanishi T
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 23 Pages: 131-134
- NAID
  130004480632
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460165
[Journal Article] Necrotic and apoptotic cells serve as nuclei for calcification on osteoblastic differentiation of human mesenchymal stem cells in vitro.2014
- Author(s)
  Fujita H, Yamamoto M, Ogino T, Kobuchi H, Ohmoto N, Aoyama E, Oka T, Nakanishi T, Inoue K, Sasaki J.
- Journal Title
  
  Cell Biochem Funct
  
  Volume: 32 Pages: 77-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Establishment of a monoclonal antibody against CD81 that decreases the proliferation of rat glioma cells2014
- Author(s)
  Fujimoto E, Mori H, Takehara M, Tanaka M, Ohashi T, Ninomiya Y, Nakanishi T
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 23 Pages: 131-134
- NAID
  130004480632
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Small Interfering RNA Targeting CD81 Decreased the Expression of Tumor Necrosis Factor-alpha and Synoviolin in SW982 Cells2013
- Author(s)
  Hanada T, Fujimoto E, Mori H, Ohashi T, Ninomiya Y, Nakanishi T
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 22 Pages: 195-200
- NAID
  130004480579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Small interfering RNA targeting CD81 decreased the expression of tumor necrosis factor-alpha and synoviolin in SW982 cells2013
- Author(s)
  Hanada T, Fujimoto E, Mori H, Ohashi T, Ninomiya Y, Nakanishi T
- Journal Title
  
  J Hard Tissue Biol
  
  Volume: 22 Pages: 195-200
- NAID
  130004480579
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA)2012
- Author(s)
  Nakanishi T, Arai Y, Mori H, Nakajima T, Kubo T
- Journal Title
  
  Arthr Res Therap
  
  Volume: 14 Pages: 52-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] 就実大学・就実短期大学における食品衛生分野での教育研究2012
- Author(s)
  中西　徹
- Journal Title
  
  食品衛生学雑誌
  
  Volume: 53 Pages: 298-300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthrits (RA)2012
- Author(s)
  Nakanishi T, Arai Y, Mori H, Nakajima T, Kubo T
- Journal Title
  
  Arthr Res Therap
  
  Volume: 14 Pages: 52-52
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Effect of risedronate on osteoblast differentiation, expression of receptor activator of NF-κB ligand and apoptosis in mesenchymalstem cells2011
- Author(s)
  Fujita H, Kurokawa K, Ogino T, Ono M, Yamamoto M, Oka T, Nakanishi T, kobayashi N, Tanaka N, Ogawa T, SUzaki E, Utsumi K, Sasaki J
- Journal Title
  
  Basic Clin Pharmacol Toxicol
  
  Volume: 109 Pages: 78-84
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA)2011
- Author(s)
  Nakanishi T
- Journal Title
  
  Arthritis Research and Therapy
  
  Volume: 14 Pages: 52-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590102
[Journal Article] ポストゲノムと神経薬理研究2009
- Author(s)
  中西徹
- Journal Title
  
  日本神経精神薬理学雑誌 29
  
  Pages: 181-188
- NAID
  10029093015
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] Small interfering RNA targeting CD81 ameliorated arthritis in rats.2009
- Author(s)
  Nakagawa S, Arai Y, Mori H, Matsushita Y, Kubo T, Nakanishi T
- Journal Title
  
  Biochem Biophys Res Commun 388
  
  Pages: 467-472
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] Signal Transduction of Inflammatory Synoviocytes in Rheumatoid Arthritis2008
- Author(s)
  Mori, H., Nakanishi, T.
- Journal Title
  
  YAKUGAKU ZASSHI 128
  
  Pages: 263-268
- NAID
  110006572180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590092
[Journal Article] ポストゲノムの炎症・リウマチ研究と創薬2008
- Author(s)
  中西徹
- Journal Title
  
  薬学雑誌 128
  
  Pages: 245-245
- NAID
  110006572177
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] Isolation of a mRNA Preferentially Expressed in Synoviocytes from Rheumatoid Arthrits That is Identical with Lumican, which Encodes a Collagen Binding Extracellular Matrix Protein2008
- Author(s)
  Mori, H, Nishida, K, Ozaki, T, Inoue, H, Nakanishi, T
- Journal Title
  
  J. Hard Tissue Biol. 17
  
  Pages: 125-130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590092
[Journal Article] ポストゲノムの炎症・リウマチ研究と創薬2008
- Author(s)
  中西徹
- Journal Title
  
  薬学雑誌 128
  
  Pages: 245-245
- NAID
  110006572177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] Signal Transduction of Inflammatory Synoviocytes in Rheumatoid Arthritis2008
- Author(s)
  Hiroki Mori, Tohru Nakanishi
- Journal Title
  
  Yakugaku zasshi 128
  
  Pages: 263-268
- NAID
  110006572180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590092
[Journal Article] 炎症性関節リウマチ滑膜細胞のシグナル伝達2008
- Author(s)
  森宏樹、中西徹
- Journal Title
  
  薬学雑誌 128
  
  Pages: 263-268
- NAID
  110006572180
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] 炎症性関節リウマチ滑膜細胞のシグナル伝達2008
- Author(s)
  森宏樹、中西徹
- Journal Title
  
  薬学雑誌 128
  
  Pages: 263-268
- NAID
  110006572180
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] Isolation of a mRNA preferentially expressed in synoviocytes from rheumatoid arthritis that is identical with lumican, which encodes a collagen binding, extracellular matrix protein.2008
- Author(s)
  Mori H, Nishida K, Ozaki T, Inoue H, Nakanishi T
- Journal Title
  
  J Hard Tissue Biol 17
  
  Pages: 125-130
- NAID
  110007081297
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] Isolation of a mRNA Preferentially Expressed in Synoviocytes from Rheumatoid Arthritis that is Identical with Lumican, which Encodes a Collagen Binding Extracellular Matrix Protein2008
- Author(s)
  Hiroki Mori, Kei-ichiro Nishida, Toshifumi Ozaki, Hiroshi Inoue, Tohru Nakanishi
- Journal Title
  
  J. Hard Tissue Biol. 17
  
  Pages: 125-130
- NAID
  110007081297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590092
[Journal Article] Characterization and gene expression profiling of human mesenchymal stem cells.2007
- Author(s)
  Mori H, Itano Y, Kobayashi N, Kosaka Y, Tanaka N, Nakanishi T
- Journal Title
  
  J Hard Tissue Biol 16
  
  Pages: 36-41
- NAID
  110006250205
- Data Source
  KAKENHI-PROJECT-19390026
[Journal Article] Characterization and Gene Expression Profiling of Human Mesenchymal Stem Cells2007
- Author(s)
  Hiroki Mori, Yoshitaro Itano, Naoya Kobayashi, Yoshikazu Kosaka, Noriaki Tanaka, Hitoshi Nagatsuka, Masahisa Inoues, Kojun Setsu, Tohru Nakanishi
- Journal Title
  
  J. Hard Tissue Biol. 16
  
  Pages: 36-41
- NAID
  110006250205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590092
[Journal Article] Expression profiles of BDNF splice variants in cultured DRG neurons stimulated with NGF. Biochem2007
- Author(s)
  Yoshikazu Matsuoka, Masataka Yokoyama, Hiroyuki Kobayashi, Megumi Omori, Yoshitaro Itano, Kiyoshi Morita, Hiroki Mori, Tohru Nakanishi
- Journal Title
  
  Biophys. Res. Commun. 362
  
  Pages: 682-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590092
[Journal Article] Characterization and gene expression profiling of human mesenchymal stem cells.2007
- Author(s)
  Mori H, Itano Y, Kobayashi N, Kosaka Y, Tanaka N, Nakanishi T.
- Journal Title
  
  J Hard Tissue Biol 16 (in press)
- NAID
  110006250205
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Expression of WISP-1(ccn4), WISP-2(ccn5) and WISP-3(ccn6) in rheumatoid arthritic synovium evaluated by DNA microarrays.2006
- Author(s)
  Mori H.Nishida K, Ozaki T, Inoue H, Setsu K, Tsujigiwa H, Nagatsuka H, Gunduz M, Nakanishi T.
- Journal Title
  
  J Hard Tissue Biol 15
  
  Pages: 89-95
- NAID
  110006151628
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development.2005
- Author(s)
  Yamaai T, Nakanishi T, Asano M, Nawachi K, Yoshimichi G, Ohyama K, Komori T, Sugimoto, T Takigawa M
- Journal Title
  
  J Bone Miner Metab. 23(4)
  
  Pages: 280-288
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591908
[Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfal-null mutant mice in late stage of embryonic development.2005
- Author(s)
  Yamaai T, Nakanishi T, Asano M, Nawachi K, Yoshimichi G, Ohyama K, Komori T, Sugimoto T, Takigawa M.
- Journal Title
  
  J Bone Miner Metab. 23(4)
  
  Pages: 280-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591908
[Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfal-null mutant in late stage of mouse embryonic development.2005
- Author(s)
  Yamaai T, Nakanishi T, Asano M, Nawachi K, Yoshimichi G, Ohyama K, Komori T, Sugimoto T, Takigawa M.
- Journal Title
  
  J Bone Miner Metab 23
  
  Pages: 280-288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Gene expression connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development2005
- Author(s)
  Yamaai T, Nakanishi T, Asano M, Nawachi K, Yoshimichi G, Ohyama K, Komori T, Sugimoto T, Takigawa M.
- Journal Title
  
  J Bone Miner.Metab. 23(4)
  
  Pages: 280-288
- Data Source
  KAKENHI-PROJECT-17591908
[Journal Article] Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.2005
- Author(s)
  Asano M, Kubota S, Nakanishi T, Nishida T, Yamaai T, Yosimichi G, Ohyama K, Sugimoto T, Murayama Y, Takigawa M.
- Journal Title
  
  Cell Commun Signal.
- NAID
  120002311460
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591908
[Journal Article] Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.2005
- Author(s)
  Asano M, Kubota S, Nakanishi T, Nishida T, Yamaai T, Yosimichi G, Ohyama K, Sugimoto T, Murayama Y, Takigawa M.
- Journal Title
  
  Cell Commun.Signal Oct. 5
  
  Pages: 3-11
- NAID
  120002311460
- Data Source
  KAKENHI-PROJECT-17591908
[Journal Article] Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.2005
- Author(s)
  Asano M, Nakanishi T(3番目)
- Journal Title
  
  Cell Commun Signal 3
  
  Pages: 1-11
- NAID
  120002311460
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.2005
- Author(s)
  Asano M, Kubota S, Nakanishi T, Nishida T, Yamaai T, Yosimichi G, Ohyama K, Sugimoto T, Murayama Y, Takigawa M
- Journal Title
  
  Cell Commun Signal. Oct 5
  
  Pages: 1-11
- NAID
  120002311460
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591908
[Journal Article] Differentiation and gene expression profiling of human esenchymal stem cells.2005
- Author(s)
  Mori H(最初), Nakanishi T(最後)
- Journal Title
  
  J Hard Tissue Biol 14
  
  Pages: 267-268
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.2005
- Author(s)
  Mima S, Nakanishi T(8番目)
- Journal Title
  
  Cancer Res 65
  
  Pages: 1868-1876
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Gene expression profiling and differentiation of immortalized human mesenchymal stem cells.2005
- Author(s)
  Mori H, Kato J, Matsuo H, Kobayashi N, Kosaka Y, Oka T, Tanaka N, Nakanishi T.
- Journal Title
  
  J Hard Tissue Biol 14
  
  Pages: 267-268
- NAID
  110005853555
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Induction of claudin-4 by nonsteroidal anti-inflammatory drugs and its contribution to their chemopreventive effect.2005
- Author(s)
  Mima S, Tsutsumi S, Ushijima H, Takeda M, Fukuda I, Yokomizo K, Suzuki K, Sano K, Nakanishi T, Tomisato W, Tsuchiya T, Mizushima T.
- Journal Title
  
  Cancer Res 65
  
  Pages: 1868-1876
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfal-null mutant in late stage of mouse embryonic development.2005
- Author(s)
  Yamaai T, Nakanishi T(2番目)
- Journal Title
  
  J Bone Miner Metab 23
  
  Pages: 280-288
- Data Source
  KAKENHI-PROJECT-17590080
[Journal Article] Overexpression of connective tissue growth factor/hypertrophic chondrocyte specific geneproduct 24 decreases bone density in adult mice and induces dwarfism.2001
- Author(s)
  Tohru Nakanishi, et. al.
- Journal Title
  
  Biochem. Biophys. Res. Coommun. 281
  
  Pages: 678-681
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13307053
[Presentation] ヒト骨肉腫細胞におけるCD81の発現とその増殖及び転移への関与2023
- Author(s)
  中西、溝尻、白井　他
- Organizer
  日本口腔腫瘍学会
- Data Source
  KAKENHI-PROJECT-20K07667
[Presentation] 新規関節リウマチ抗体薬開発のためのキメラ抗体作製2019
- Author(s)
  山崎勤、新井祐志、中川周士、久保俊一、中西　徹
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] Application of tetraspanin CD81 siRNA for diagnosis and therapy of rheumatoid arthritis2019
- Author(s)
  Yamasaki T, Nakanishi T
- Organizer
  Franco-Japanese Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] Application of genome editing in medical treatment2019
- Author(s)
  Nakanishi T
- Organizer
  Franco-Japanese Seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] 関節リウマチにおけるキメラ抗体の作製2019
- Author(s)
  山崎勤、中川周士、新井祐志、久保俊一、中西　徹
- Organizer
  日本薬学会139年会
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] 新規関節リウマチ治療薬のターゲットCD81に対する抗体薬の開発2019
- Author(s)
  山崎勤、中川周士、新井祐志、久保俊一、中西　徹
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] Application of tetraspanin CD81 siRNA for diagnosis and therapy of rheumatoid arthritis2018
- Author(s)
  Yamasaki T、Nakanishi T
- Organizer
  ASEAN-JAPAN Genome Medicine Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] Development of tetraspanin CD81 as a clinical target of rheumatoid arthritis and breast cancer2018
- Author(s)
  Nakanishi T
- Organizer
  Internationak Conference on Precision Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] テトラスパニンCD81を標的とした新規次世代リウマチ治療薬の開発2017
- Author(s)
  中西　徹、山崎　勤、新井祐志、中川周士、久保俊一
- Organizer
  硬組織再生生物学会
- Data Source
  KAKENHI-PROJECT-17K08379
[Presentation] 抗CD81モノクローナル抗体を用いたリウマチ診断用サンドイッチELISAの確立2017
- Author(s)
  三島　遥、山崎　勤、秋山勝紀、秋山亮子、田仲美幸、藤本恵利香、中西　徹
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26460165
[Presentation] テトラスパニンCD81を標的とする新規リウマチ治療薬の開発2014
- Author(s)
  中川周士、新井祐志、森宏樹、松下有美、久保俊一、中西徹
- Organizer
  日本薬学会
- Place of Presentation
  熊本
- Year and Date
  2014-03-27
- Data Source
  KAKENHI-PROJECT-23590102
[Presentation] テトラスパニンCD81を標的とした新規関節リウマチ治療薬および診断薬の開発2012
- Author(s)
  中西　徹
- Organizer
  バイオテクノロジー国際会議・国際バイオEXPO
- Place of Presentation
  東京ビッグサイト（東京）
- Data Source
  KAKENHI-PROJECT-23590102
[Presentation] テトラスパニンCD81を標的とした新規関節リウマチ治療薬および診断薬の開発2011
- Author(s)
  中西徹
- Organizer
  バイオテクノロジー国際会議・国際バイオEXPO
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23590102
[Presentation] Application of Tetraspanin CD81 RNAi for Diagnosis and Therapy of Rheumatoid Arthritis (RA)2011
- Author(s)
  Nakanishi T
- Organizer
  1st Bio-Rheumatology International Congress/8th GARN Meeting Tokyo(招待講演)
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23590102
[Presentation] Application of Tetraspanin CD81 RNAi for Diagnosis and Therapy of RA2009
- Author(s)
  Nakanishi T.
- Organizer
  CEMD-2009
- Place of Presentation
  Beijin
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-19390026
[Presentation] 関節炎におけるテトラスパニンの機能解析2009
- Author(s)
  松下有美, 森宏樹, 中西徹
- Organizer
  第129回日本薬学会
- Place of Presentation
  京都国際会館
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19390026
[Presentation] 関節炎におけるテトラスパニンの機能解析2009
- Author(s)
  森宏樹, 松下有美, 岡田充泰, 中島利博, 中川周士, 新井裕志, 久保俊一, 中西徹
- Organizer
  日本薬学会第129年会
- Place of Presentation
  国立京都国際会館など(京都市)
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-19590092
[Presentation] DNAマイクロアレイによる関節リウマチ滑膜関連遺伝子の単離とWISP遺伝子を中心とするその解析(学会賞受賞講演)2008
- Author(s)
  森宏樹, 中西徹
- Organizer
  第17回硬組織再生生物学会
- Place of Presentation
  徳島文理大学
- Year and Date
  2008-08-30
- Data Source
  KAKENHI-PROJECT-19390026
[Presentation] Establishment of overexpression system of multifunctional CCN family proteins for structural analysis2008
- Author(s)
  Junko Kato, Hiroki Mori, and Tohru Nakanishi
- Organizer
  The ASCB 48th Annual Meeting
- Place of Presentation
  Moscone Center, San Francisco, CA, USA
- Year and Date
  2008-12-14
- Data Source
  KAKENHI-PROJECT-19590092
[Presentation] DNAチップを用いた関節リウマチ原因遺伝子の解明2008
- Author(s)
  松下有美, 森宏樹, 西田圭一郎, 尾崎敏文, 長塚仁, 中西徹
- Organizer
  第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山コンベンションセンター「ママカリフォーラム」(岡山市)
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-19590092
[Presentation] 炎症性疼痛においてBDNF遺伝子は後根神経節からプロモーター選択的に発現誘導される2008
- Author(s)
  松岡義和, 横山正尚, 小林宏行, 大森恵, 板野義太郎, 森田潔, 森宏樹, 中西徹
- Organizer
  日本薬学会第128年会
- Place of Presentation
  パシフィコ横浜など(横浜市)
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-19590092
[Presentation] アセチルコリン受容体ノックアウトマウスの遺伝子発現解析2008
- Author(s)
  岡田充泰, 森宏樹, Maskos Uw, Changeux Jean-Pierre, 筒井公子, 中西徹
- Organizer
  第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  岡山コンベンションセンター「ママカリフォーラム」(岡山市)
- Year and Date
  2008-11-08
- Data Source
  KAKENHI-PROJECT-19590092
[Presentation] DNAマイクロアレイによる関節リウマチ滑膜関連遺伝子の単離とWISP遺伝子を中心とするその解析2008
- Author(s)
  森宏樹, 西田圭一郎, 中西徹
- Organizer
  第17回硬組織再生生物学会
- Place of Presentation
  徳島文理大学(徳島市)
- Year and Date
  2008-08-30
- Data Source
  KAKENHI-PROJECT-19590092
[Presentation] ヒト間葉系幹細胞の遺伝子発現解析と分化制御機構の解明2007
- Author(s)
  永留舞, 森宏樹, 岡田充泰, 松下有美, 小阪芳和, 小林直哉, 田中紀章, 中西徹
- Organizer
  第46回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
- Place of Presentation
  高知市文化プラザ「かるぽーと」,四国医療工学専門学校(高知市)
- Year and Date
  2007-11-11
- Data Source
  KAKENHI-PROJECT-19590092
[Presentation] 関節リウマチ滑膜細胞におけるクラスター分化抗原CD81の役割2007
- Author(s)
  森宏樹、中西徹
- Organizer
  第17回硬組織再生生物学会
- Place of Presentation
  松本歯科大学
- Year and Date
  2007-09-22
- Data Source
  KAKENHI-PROJECT-19390026
[Presentation] テトラスパニンCD81を標的とする新規リウマチ治療薬の開発
- Author(s)
  中川周士、新井祐志、森　宏樹、松下有美、久保俊一、中西　徹
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本大学
- Data Source
  KAKENHI-PROJECT-23590102

1. TAKIGAWA Masaharu (20112063)

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NAKANISHI Toru 中西 徹

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Development of anti-tumor drugs targeting CD81Principal Investigator

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Development of novel gene therapy for rheumatoid arthritisPrincipal Investigator

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Development of novel therapeutic compounds for rheumatoid arthritis targeting CD81Principal Investigator

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Development of novel antibody therapy targeting tetraspanin CD81Principal Investigator

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Isolation and identification of CD81 as a novel target for treatment of rheumatoid arthritis.Principal Investigator

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Analysis of stem-cell differentiation mechanism by using DNA microarray and novel bisulfite modification.Principal Investigator

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間葉系幹細胞の遺伝子発現プロファイル解析と硬組織再生への応用Principal Investigator

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NAKANISHI Toru 中西徹