Kuzuyama Tomohisa 葛山智久

… Alternative Names

KUZUYAMA Tomohisa 葛山智久

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Researcher Number	30280952
Other IDs	https://orcid.org/0000-0002-7221-5858
External Links
Affiliation (Current)	2026: 東京大学, 大学院農学生命科学研究科(農学部), 教授
Affiliation (based on the past Project Information) *help	2018 – 2025: 東京大学, 大学院農学生命科学研究科(農学部), 教授 2014 – 2017: 東京大学, 生物生産工学研究センター, 准教授 2011: The University of Tokyo, 准教授 2011: 東京大学, 生物生産工学センター, 准教授 2009 – 2011: The University of Tokyo, 生物生産工学研究センター, 准教授 … More 2007: The University of Tokyo, Biotechnology Research Center, Associate Professor 2004 – 2006: 東京大学, 生物生産工学研究センター, 助教授 2003: 東大, 分子細胞生物学研究所, 助手 1996 – 2002: 東京大学, 分子細胞生物学研究所, 助手 1996: University of Tokyo, Institute of Molecular and Cellular Biosciences, Assist. Less
Review Section/Research Field	Principal Investigator Biological Sciences / Bioproduction chemistry/Bioorganic chemistry / Science and Engineering / Bioproduction chemistry/Bioorganic chemistry / Transformative Research Areas, Section (II) / Science and Engineering / Bioorganic chemistry / Medium-sized Section 38:Agricultural chemistry and related fields / Basic Section 38040:Bioorganic chemistry-related / Bioorganic chemistry Except Principal Investigator Science and Engineering / Bioproduction chemistry/Bioorganic chemistry / Fisheries chemistry
Keywords	Principal Investigator 生合成 / 放線菌 / 遺伝子 / 反応機構 / テルペノイド / 酵素 / テルペン / ポリケチド / ポリケタイド / Streptomyces … More / biosynthesis / 天然有機化合物 / 生物活性物質 / 環化酵素 / 抗菌剤 / 阻害剤 / メバロン酸経路 / 枯草菌 / イソプレノイド / クローニング / isoprenoid / nonmevalonate pathway / 天然物化学 / 生体分子 / ホスホン酸 / versipelostatin / 生体触媒 / ヌクレオシド / 生理活性 / 結晶構造 / プレニルトランスフェラーゼ / マクロサイクリック化合物 / 除草剤 / 抗マラリア剤 / 非メバロン酸経路 / 大腸菌 / IPP isomerase / mevalonate pathway / 生合成酵素 / メロテルペノイド / 情報科学 / 計算科学 / 有機合成 / 生物合成 / 国際交流 / 環化 / ヌクレオチド / 核酸 / 核酸系化合物 / 結晶構造解析 / 天然物 / 生合成遺伝子 / reaction mechanism / terpene / carbazole / nucleoside antibiotic / Biosynthesis / 生合成マシナリー / 電子環状反応 / 天然化合物 / cloning / gene cluster / macro-cyclic compound / グリコシルトランスフェラーゼ / 生合成遺伝子クラスター / 異種発現 / 抗生物質 / アセトアセチルコエンザイムA / チオラーゼ / 抗菌性 / 法線菌 / 微生物変換 / フラボノイド / プレニル基転移酵素 / プレニル化 / メチルエリスリトールリン酸経路 / 脱水酵素 / 糖 / 放射菌 / フラボドキシン / 形質転換株 / スクリーニング / 変異株 / 非メバロン路酸経路 / ナフテルピン / Bacillus subtilis / antibacterial compound / Staphylococcus aureus / Streptomyce / metabolic pathway / cytidylyltransferase / kinase / mevalonate / HMG-CoA reductase / terpenoid … More Except Principal Investigator BE-40644 / 天然物化学 / 生合成 / 生物分子科学 / 生合成工学 / 合成生物学 / 生合成リデザイン / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / 3-hydroxy-3-methylglutaryl coenzyme A reductase / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate / novobiocin / HMG CoA reductase / carquinostatin / longestin / 非メバロン酸経路 / メバロン酸経路 / 生物分子化学 / nonmevalonate pathway / mevalonate pathway / 1- deoxyxylulose 5-phosphate reductoisomerase / 2-phospho-4-(cytidine 5' -diphospho)-2-C-methyl-D-erythritol / 2-C-methyl-D-erythritol 4-phosphate / 1-deoxyxylulose 5-phosphate reductoisomerase / 2-C-methylerythritol / ノボビオシン / 1-deoxyxylulose / 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase / 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 2-C-methyl-D-erythriitol 4-phosphate / 1-deoxyxylulose5-phosphate reductoisomerase / 2-phospho-4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 2-C-methyl-D-erythritol4-phosphate / 3-hydroxy-3-methylglutaryl coezyme A reductase / Streptomyces aureouvifer / HMG Co-A reductase / non-mevalonate pathway / ロンゲスチンの生合成研究 / Streptomyces argenteolus / メナキノンの生合成 / ナフテルピンの生合成 / Streptomyces aeriouvifer / HMG CoAreducatase / Streptomyces aeriouvider / テルペノイド化合物の生合成 / TANGO-HMBC / BE-40644の生合成 / naphterpin / Transcriptional factor / Biosensor / Crystallin gene / Polycomb genes / Transgenics / B cell / Immunological tolerance / T cell / 転写因子 / 有機リン系農薬センサー / 水晶体特異的遺伝子発現 / ポリコ-ム遺伝子 / 発生工学 / B細胞 / 免疫寛容 / T細胞 / 生物活性 / 組換え微生物 / テルペン / マラリア / 枯草菌 / 遺伝子操作 / 抗菌活性 / テルペン生合成 / 海洋生物 / 化学酵素合成 / 大腸菌 / ペプチド合成酵素 / 天然物 / ゲノム / 抗腫瘍性物質 / 抗生物質 / 二次代謝産物 / メタボローム / バイオインフォマティクス / 物質生産 / ゲノム情報 / (E)-4-hydroxy-3-methylbut-2-eneyl 1-diphosphate reductase / プレスクアレンニリン酸 / メチルエリスリトールリン酸 / Botryococcene / プレスクアレン二リン酸 / スクアレン / イソプレノイド / Botryococcus braunii / 代替石油生産 / 炭化水素 / トリテルペン / 微細藻類 Less

Systems biosynthetics based on accumulation, prediction, and creation of biological reactionsArea Organizer
- Area Organizer
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
予知生合成科学・研究総括班Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
構造多様性一挙構築型生体反応の集積・予知・創出Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
Creation of Innovative Nucleic Acid-Based Compounds by Redesigning Biosynthetic MachineryPrincipal Investigator
- Principal Investigator
  
  Kuzuyama Tomohisa
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  The University of Tokyo
Exploratory research for innovative terpene synthases without existing motif sequencesPrincipal Investigator
- Principal Investigator
  
  Kuzuyama Tomohisa
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  The University of Tokyo
メロテルペノイド生合成マシナリーの機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for JSPS Fellows
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokyo
Redesigning Biosynthetic Machineries (Project Team)
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Development and precise functional analysis of innovative biosynthetic machinery to create complex skeletonsPrincipal Investigator
- Principal Investigator
  
  Kuzuyama Tomohisa
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Redesigning Biosynthetic Machineries (International Activity Support Team)
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Reaction mechanism of unique terpene synthases, that is elucidated by synthetic chemistry and structural biologyPrincipal Investigator
- Principal Investigator
  
  Kuzuyama Tomohisa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  The University of Tokyo
Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites
- Principal Investigator
  
  OIKAWA Hideaki
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Hokkaido University
テルペンおよびヌクレオシド系抗生物質生合成マシナリーの解明とエンジニアリングPrincipal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Search for anti-malaria agents from marine organisms
- Principal Investigator
  
  MATSUNAGA Shigeki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Fisheries chemistry
- Research Institution
  The University of Tokyo
遺伝情報を利用した放線菌二次代謝産物の同定と生合成研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Studies on the mechanisms for biosynthesis of useful hydrocarbons by a green microalga based on data from EST analyses.
- Principal Investigator
  
  OKADA Shigeru
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Fisheries chemistry
- Research Institution
  The University of Tokyo
非天然型プレニル化芳香族化合物合成系の構築とその利用Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
イソプレンユニット生合成経路を標的とした抗菌剤と抗マラリア剤開発のための探索研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
Biosynthetic studies on a novel 17-membered macro-cyclic compound produced by a Streptomyces strainPrincipal Investigator
- Principal Investigator
  
  KUZUYAMA Tomohisa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
非天然型プレニル化芳香族化合物合成系の構築Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
イソプレンユニット生合成経路を標的とした抗菌剤と抗マラリア剤開発のための探索研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
放線菌の生産する新規17員環マクロサイクリック化合物の生合成研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
新規一次代謝経路、非メバロン酸経路を標的とした抗菌剤開発のための探索研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関与する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関与する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
テルペン-ポリケタイド融合化合物ナフテルピンの生合成Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関与する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
非メバロン酸経路特異的阻害物質に関する研究Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
テルペンーポリケタイド融合化合物ナフテルピンの生合成Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Science and Engineering
- Research Institution
  The University of Tokyo
未解明一次代謝経路、非メバロン酸経路に関する遺伝子の機能解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
新規テルペン生合成経路、非メバロン酸経路の解明、及びその生合成遺伝子の取得Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Biosynthetic studies on terpenoids produced by Actinomycetes by focusing on the nonmevalonate pathway
- Principal Investigator
  
  SETO Haruo
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
放線菌の生産するテルペノイドの生合成遺伝子のクローニングと解析Principal Investigator
- Principal Investigator
  
  葛山智久
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo
Regulation of Gene Expression
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Chiba University, School of Medicine
Biosynthetic Studies of terpenoids produced by actinomycetes
- Principal Investigator
  
  SETO Haruo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  The University of Tokyo

[Book] "Chapter 12 Mevalonate Pathway in Archaea and Bacteria." In Comprehensive Natural Products II. Chemistry & Biology2010
- Author(s)
  Kuzuyama T., H.Hemmi, S.Takahashi(共著)
- Total Pages
  24
- Publisher
  Elsevier
- Data Source
  KAKENHI-ORGANIZER-22108001
[Journal Article] Mechanistic Characterization of Diterpene Synthase Pairs for Tricyclic Diterpenes from Cyanobacteria2025
- Author(s)
  Yu Jiayi、Shiraishi Taro、Taizoumbe Kizerbo A.、Karasuno Yusaku、Yoshida Ayako、Nishiyama Makoto、Dickschat Jeroen S.、Kuzuyama Tomohisa
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 147 Issue: 14 Pages: 11896-11905
- DOI
  10.1021/jacs.4c16710
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05120
[Journal Article] Biosynthesis of the tetrahydroxynaphthalene-derived meroterpenoid furaquinocin via reductive deamination and intramolecular hydroalkoxylation of an alkene2025
- Author(s)
  Noguchi Tomohiro、Zhao Fan、Moriwaki Yoshitaka、Yamamoto Hideaki、Kudo Kei、Nagata Ryuhei、Tomita Takeo、Terada Tohru、Shimizu Kentaro、Nishiyama Makoto、Kuzuyama Tomohisa
- Journal Title
  
  Chemical Science
  
  Volume: - Issue: 18 Pages: 7912-7920
- DOI
  10.1039/d4sc08319a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05120, KAKENHI-PLANNED-22H05126
[Journal Article] In vivo and in vitro Reconstitution of Biosynthesis of N‐Prenylated Phenazines Revealing Diverse Phenazine‐Modifying Enzymes2024
- Author(s)
  Kato Teruhito、Xia Dan、Ozaki Taro、Nakao Tomoyo、Zhao Ping、Nishiyama Makoto、Shiraishi Taro、Kuzuyama Tomohisa
- Journal Title
  
  ChemBioChem
  
  Volume: 26 Issue: 2
- DOI
  10.1002/cbic.202400723
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05120
[Journal Article] QM/MM Study of the Catalytic Mechanism and Substrate Specificity of the Aromatic Substrate C-Methyltransferase Fur62024
- Author(s)
  Zhao Fan、Moriwaki Yoshitaka、Noguchi Tomohiro、Shimizu Kentaro、Kuzuyama Tomohisa、Terada Tohru
- Journal Title
  
  Biochemistry
  
  Volume: 63 Issue: 6 Pages: 806-814
- DOI
  10.1021/acs.biochem.3c00556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12122, KAKENHI-PLANNED-22H05120, KAKENHI-PLANNED-22H05126
[Journal Article] Discovery of type II polyketide synthase-like enzymes for the biosynthesis of cispentacin2023
- Author(s)
  Hibi Genki、Shiraishi Taro、Umemura Tatsuki、Nemoto Kenji、Ogura Yusuke、Nishiyama Makoto、Kuzuyama Tomohisa
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 8065-8065
- DOI
  10.1038/s41467-023-43731-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22H05120
[Journal Article] Complete Biosynthetic Pathway of the Phosphonate Phosphonothrixin: Two Distinct Thiamine Diphosphate-Dependent Enzymes Divide the Work to Form a C-C Bond2022
- Author(s)
  Zhu Yuxun、Shiraishi Taro、Lin Jianwen、Inaba Keito、Ito Atsuro、Ogura Yusuke、Nishiyama Makoto、Kuzuyama Tomohisa
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 37 Pages: 16715-16719
- DOI
  10.1021/jacs.2c06546
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22H05120
[Journal Article] Total Synthesis and Stereochemistry Assignment of Nucleoside Antibiotic A‐949642022
- Author(s)
  Shao Xiaofei、Zheng Chang、Xu Peng、Shiraishi Taro、Kuzuyama Tomohisa、Molinaro Antonio、Silipo Alba、Yu Biao
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 61 Issue: 14
- DOI
  10.1002/anie.202200818
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02127
[Journal Article] Biosynthetic pathways and enzymes involved in the production of phosphonic acid natural products2021
- Author(s)
  Shiraishi T, Kuzuyama T.
- Journal Title
  
  Biosci Biotechnol Biochem
  
  Volume: 85 Issue: 1 Pages: 42-52
- DOI
  10.1093/bbb/zbaa052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Reconstitution of a Highly Reducing Type II PKS System Reveals 6π-Electrocyclization Is Required for o-Dialkylbenzene Biosynthesis2021
- Author(s)
  Zhang J, Yuzawa S, Thong WL, Shinada T, Nishiyama M, Kuzuyama T.
- Journal Title
  
  J Am Chem Soc
  
  Volume: 143 Issue: 7 Pages: 2962-2969
- DOI
  10.1021/jacs.0c13378
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-19H04661, KAKENHI-PROJECT-17H06168
[Journal Article] Biosynthesis of the nucleoside antibiotic angustmycins: identification and characterization of the biosynthetic gene cluster reveal unprecedented dehydratase required for exo-glycal formation2021
- Author(s)
  Shiraishi Taro、Xia Jiaqi、Kato Teruhito、Kuzuyama Tomohisa
- Journal Title
  
  The Journal of Antibiotics
  
  Volume: 74 Issue: 11 Pages: 830-833
- DOI
  10.1038/s41429-021-00466-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02127
[Journal Article] Recent Advances in the Biosynthesis of Carbazoles Produced by Actinomycetes2020
- Author(s)
  Kobayashi M, Kuzuyama T.
- Journal Title
  
  Biomolecules
  
  Volume: 10 Issue: 8 Pages: 1147-1147
- DOI
  10.3390/biom10081147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] 新奇骨格を創成する革新的生合成マシナリーの開拓2019
- Author(s)
  白石太郎、葛山智久
- Journal Title
  
  Farumashia
  
  Volume: 55 Issue: 7 Pages: 679-683
- DOI
  10.14894/faruawpsj.55.7_679
- NAID
  130007671598
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Structural and mechanistic insight into terpene synthases that catalyze the irregular non-head-to-tail coupling of prenyl substrates2019
- Author(s)
  Kobayashi, M., Kuzuyama, T.
- Journal Title
  
  Chembiochem
  
  Volume: 20 Issue: 1 Pages: 29-33
- DOI
  10.1002/cbic.201800510
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces2019
- Author(s)
  Kobayashi M, Tomita T, Shin-ya K, Nishiyama M, Kuzuyama T.
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 58 Issue: 38 Pages: 13349-13353
- DOI
  10.1002/anie.201906864
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Recent advances in the biosynthesis of nucleoside antibiotics2019
- Author(s)
  Shiraishi T, Kuzuyama T.
- Journal Title
  
  J Antibiot
  
  Volume: 72 Issue: 12 Pages: 913-923
- DOI
  10.1038/s41429-019-0236-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] An Unusual Skeletal Rearrangement in the Biosynthesis of the Sesquiterpene Trichobrasilenol from Trichoderma2019
- Author(s)
  Murai K, Lauterbach L, Teramoto K, Quan Z, Barra L, Yamamoto T, Nonaka K, Shiomi K, Nishiyama M, Kuzuyama T, Dickschat JS.
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 58 Issue: 42 Pages: 15046-15050
- DOI
  10.1002/anie.201907964
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] The Amipurimycin and Miharamycin Biosynthetic Gene Clusters: Unraveling the Origins of 2-Aminopurinyl Peptidyl Nucleoside Antibiotics2019
- Author(s)
  Romo AJ, Shiraishi T, Ikeuchi H, Lin GM, Geng Y, Lee YH, Liem PH, Ma T, Ogasawara Y, Shin-ya K, Nishiyama M, Kuzuyama T, Liu HW.
- Journal Title
  
  J Am Chem Soc
  
  Volume: 141 Issue: 36 Pages: 14152-14159
- DOI
  10.1021/jacs.9b03021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: Identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway2019
- Author(s)
  Shiraishi, T., Nishiyama, M., Kuzuyama T.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 17 Issue: 3 Pages: 461-466
- DOI
  10.1039/c8ob02765j
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Biochemical and structural analysis of FomD that catalyzes the hydrolysis of cytidylyl (S)-2-hydroxypropylphosphonate in fosfomycin biosynthesis2018
- Author(s)
  Sato, S., Miyanaga, A., Kim, S. Y., Kuzuyama, T., Kudo, F., Eguchi, T.
- Journal Title
  
  Biochemistry
  
  Volume: 57 Issue: 32 Pages: 4858-4866
- DOI
  10.1021/acs.biochem.8b00690
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-18H02095
[Journal Article] Discovery of an antibacterial isoindolinone-containing tetracyclic polyketide by cryptic gene activation and characterization of its biosynthetic gene cluster2018
- Author(s)
  Thong, W. L., Shin-ya, K., Nishiyama, M., Kuzuyama, T.
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 13 Issue: 9 Pages: 2615-2622
- DOI
  10.1021/acschembio.8b00553
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] C-Methylation Catalyzed by Fom3, a Cobalamin-Dependent Radical S-adenosyl-l-methionine Enzyme in Fosfomycin Biosynthesis, Proceeds with Inversion of Configuration2018
- Author(s)
  Sato, S., Kudo, F., Kuzuyama, T., Hammerschmidt, F., Eguchi, T.
- Journal Title
  
  Biochemistry
  
  Volume: 57 Issue: 33 Pages: 4963-4966
- DOI
  10.1021/acs.biochem.8b00614
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-18H02095
[Journal Article] Discovery of Unprecedented Hydrazine-Forming Machinery in Bacteria2018
- Author(s)
  Matsuda Kenichi、Tomita Takeo、Shin-ya Kazuo、Wakimoto Toshiyuki、Kuzuyama Tomohisa、Nishiyama Makoto
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 140 Issue: 29 Pages: 9083-9086
- DOI
  10.1021/jacs.8b05354
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06448, KAKENHI-PLANNED-16H06453, KAKENHI-PROJECT-17H06168, KAKENHI-PROJECT-18H02581, KAKENHI-PROJECT-17F17114
[Journal Article] Characterization of bafilomycin biosynthesis in Kitasatospora setae KM-6054 and comparative analysis of gene clusters in Actinomycetales microorganisms2017
- Author(s)
  Nara, A., Hashimoto, T., Komatsu, M., Nishiyama, M., Kuzuyama, T., Ikeda, H.
- Journal Title
  
  J. Antibiot.
  
  Volume: 印刷中 Issue: 5 Pages: 616-624
- DOI
  10.1038/ja.2017.33
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PLANNED-16H06447
[Journal Article] Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer2017
- Author(s)
  Kei Kudo, Taro Ozaki, Kazuo Shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 139 Issue: 20 Pages: 6799-6802
- DOI
  10.1021/jacs.7b02071
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol2017
- Author(s)
  Takeo Tomita, Seung-Young Kim, Kazuya Teramoto, Ayuko Meguro, Taro Ozaki, Ayako Yoshida, Yudai Motoyoshi, Naoki Mori, Ken Ishigami, Hidenori Watanabe, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 12 Issue: 6 Pages: 1621-1628
- DOI
  10.1021/acschembio.7b00154
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PROJECT-17J40083
[Journal Article] Structure and Mechanism of the Monoterpene Cyclolavandulyl Diphosphate Synthase that Catalyzes Consecutive Condensation and Cyclization2017
- Author(s)
  Takeo Tomita, Masaya Kobayashi, Yuma Karita, Yoko Yasuno, Tetsuro Shinada, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  Angew. Chem. Int Ed.
  
  Volume: 56 Issue: 47 Pages: 14913-14917
- DOI
  10.1002/anie.201708474
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05448, KAKENHI-PROJECT-15J10131
[Journal Article] Methylcobalamin-Dependent Radical SAM C-Methyltransferase Fom3 Recognizes Cytidylyl-2-hydroxyethylphosphonate and Catalyzes the Nonstereoselective C-Methylation in Fosfomycin Biosynthesis2017
- Author(s)
  Sato Shusuke、Kudo Fumitaka、Kim Seung-Young、Kuzuyama Tomohisa、Eguchi Tadashi
- Journal Title
  
  Biochemistry
  
  Volume: 56 Issue: 28 Pages: 3519-3522
- DOI
  10.1021/acs.biochem.7b00472
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06451, KAKENHI-PLANNED-16H06453, KAKENHI-PUBLICLY-17H05434, KAKENHI-PROJECT-15H03834
[Journal Article] Mechanistic insights into Diels-Alder reactions in natural product biosynthesis2017
- Author(s)
  Hashimoto, T., Kuzuyama, T.
- Journal Title
  
  Curr. Opin. Chem. Biol.
  
  Volume: 35 Pages: 117-123
- DOI
  10.1016/j.cbpa.2016.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Fosfomycin Biosynthesis via Transient Cytidylylation of 2-Hydroxyethylphosphonate by the Bifunctional Fom1 Enzyme2017
- Author(s)
  Su-Hee Cho, Seung-Young Kim, Takeo Tomita, Taro Shiraishi, Jin-Soo Park, Shusuke Sato, Fumitaka Kudo, Tadashi Eguchi, Nobutaka Funa, Makoto Nishiyama and Tomohisa Kuzuyama
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 12 Pages: 2209-2215
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16H06453
[Journal Article] Biosynthetic studies on terpenoids produced by Streptomyces2017
- Author(s)
  Kuzuyama, T.
- Journal Title
  
  J. Antibiot.
  
  Volume: 印刷中 Issue: 7 Pages: 811-818
- DOI
  10.1038/ja.2017.12
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-16H06453, KAKENHI-PROJECT-26292058
[Journal Article] An unusaual terpene cyclization mechanism involving a carbon-carbon bond rearrangement2015
- Author(s)
  Meguro, A., Motoyoshi, Y., Teramoto, K., Ueda, S., Totsuka, Y., Tomita, T., Kim, S.-Y., Kimura, T. Igarashi, M., Sawa, R., Shinada, T., Nishiyama, M. and Kuzuyama, T.
- Journal Title
  
  Angewandte Chemie
  
  Volume: 127 Issue: 14 Pages: 4427-4430
- DOI
  10.1002/anie.201411923
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23228001, KAKENHI-PROJECT-26292058
[Journal Article] Cation-stitching cascade: exquisite control of terpene cyclization in cyclooctatin biosynthesis2015
- Author(s)
  Sato, H., Teramoto, K., Masumoto, Y., Tezuka, N., Sakai, K., Ueda, S., Totsuka, Y., Shinada, T., Nishiyama, M., Wang, C., Kuzuyama, T., Uchiyama, M.
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Issue: 1 Pages: 18471-18471
- DOI
  10.1038/srep18471
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23228001, KAKENHI-PROJECT-14F04908, KAKENHI-PROJECT-26292058, KAKENHI-PROJECT-24229001
[Journal Article] Terpene synthases are widely distributed in bacteria.2015
- Author(s)
  Y. Yamada, T. Kuzuyama, M. Komatsu, K. Shin-ya, S. Omura, D.E. Cane, H. Ikeda
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 112 Pages: 857-857
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22108001
[Journal Article] Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes2015
- Author(s)
  Y. Ye, A. Minami, A. Mandi, C. Liu, T. Taniguchi, T. Kuzuyama, K. Monde, K. Gomi, and H. Oikawa
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Issue: 36 Pages: 11846-11853
- DOI
  10.1021/jacs.5b08319
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H01835, KAKENHI-PROJECT-15H03111, KAKENHI-PROJECT-26292058
[Journal Article] Terpene synthases are widely distributed in bacteria2015
- Author(s)
  Y. Yamada, T. Kuzuyama, M. Komatsu, K. Shin-ya, S. Omura, D.E. Cane, H. Ikeda
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 112 Issue: 3 Pages: 857-862
- DOI
  10.1073/pnas.1422108112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22108006, KAKENHI-PROJECT-25450112, KAKENHI-PROJECT-26292058
[Journal Article] Crystallization and preliminary X-ray diffraction analysis of cyclolavandulyl diphosphate synthase, a new member of the cis-isoprenyl diphosphate synthase superfamily2014
- Author(s)
  Tomita T, Ozaki T, Matsuda K, Nishiyama M, Kuzuyama T.
- Journal Title
  
  Acta Crystallographica Section F Structural Biology Communications
  
  Volume: 70 Issue: 10 Pages: 1410-1413
- DOI
  10.1107/s2053230x14018883
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26292058
[Journal Article] Cyclolavandulyl skeleton biosynthesis via both condensation and cyclization catalyzed by an unprecedented member of the cis-isoprenyl diphosphate synthase superfamily2014
- Author(s)
  Ozaki T, Zhao P, Shinada T, Nishiyama M, Kuzuyama T.
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 136 Issue: 13 Pages: 4837-4840
- DOI
  10.1021/ja500270m
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26292058
[Journal Article] 構造多様性を創出する新奇テルペノイド合成酵素の発見2014
- Author(s)
  尾崎太郎、葛山智久
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 72 Pages: 412-414
- NAID
  40020209341
- Data Source
  KAKENHI-PROJECT-26292058
[Journal Article] The single cellular green microalga Botryococcus braunii, race B possesses three distinct 1-deoxy-D-xylulose 5-phosphate synthases2012
- Author(s)
  D. Matsushima、H. Jenke-Kodama、Y. Sato、Y. Fukunaga、K. Sumimoto、T. Kuzuyama、S. Matsunaga、S. Okada
- Journal Title
  
  Plant Sci.
  
  Volume: 185-186 Pages: 309-320
- DOI
  10.1016/j.plantsci.2012.01.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380130
[Journal Article] テルペノイドの増産を可能にする新規アセトアセチルCoA合成酵素2011
- Author(s)
  岡村英治、葛山智久
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 69 Pages: 125-126
- NAID
  10027781267
- Data Source
  KAKENHI-PROJECT-21380071
[Journal Article] Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway2010
- Author(s)
  Eiji Okamura, Takeo Tomita, Ryuichi Sawa, Makoto Nishiyama, Tomohisa Kuzuyama
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 11265-11270
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380071
[Journal Article] Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway2010
- Author(s)
  Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T
- Journal Title
  
  Proc.Natl.Acad.Sci.USA
  
  Volume: 107 Pages: 11265-11270
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22108001
[Journal Article] Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford aditerpene cyclase and two P450 hydroxylases2009
- Author(s)
  Kim S-Y., P.Zhao, M.Igarashi, R.Sawa, M.Nishiyama, T.Kuzuyama
- Journal Title
  
  Chemistry & Biology 16
  
  Pages: 736-743
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380071
[Journal Article] テルペノイドーポリケチド融合化合物の生合成とその鍵酵素を利用した有用物質生産2007
- Author(s)
  T. Kuzuyama
- Journal Title
  
  蛋白質・核酸・酵素 52
  
  Pages: 1736-1741
- Data Source
  KAKENHI-PROJECT-18018008
[Journal Article] Preferential recognition of a microbial metabolite by human Vγ2Vδ2 T cells.2007
- Author(s)
  Puan, K.J., C. Jin, H. Wang, G. Sarikonda, A.M. Raker, H.K. Lee, M.I. Samuelson, E. Marker-Hermann, L. Pasa-Tolic, E. Nieves, J.L. Giner, T. Kuzuyama, and C.T. Morita.
- Journal Title
  
  Int. Immunol. 19
  
  Pages: 657-673
- NAID
  10027388917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18032022
[Journal Article] 天然有機化合物の多様性を生み出す芳香族基質プレニル基転移酵素2006
- Author(s)
  葛山智久, 熊野匠人, 西山真
- Journal Title
  
  ファインケミカル 35・2
  
  Pages: 5-14
- Data Source
  KAKENHI-PROJECT-17019011
[Journal Article] 天然有機化合物の多様性を生み出す芳香族基質プレニル基転移酵素2006
- Author(s)
  葛山智久, 熊野匠人
- Journal Title
  
  ファインケミカル 35・2
  
  Pages: 5-14
- Data Source
  KAKENHI-PROJECT-18018008
[Journal Article] Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products2005
- Author(s)
  Tomohisa Kuzuyama, Joseph P.Noel, Stephane B.Richard
- Journal Title
  
  Nature 435
  
  Pages: 983-987
- Data Source
  KAKENHI-PROJECT-17019011
[Patent] Novel Aromatic Prenyltransferases, Nucleic Acids Encoding Same and Uses2006
- Inventor(s)
  Tomohisa Kuzuyama, Joseph P.Noel, Stephane B.Richard
- Industrial Property Rights Holder
  Toudai TLO, The Salk Institute for Biological Studies
- Filing Date
  2006-01-27
- Data Source
  KAKENHI-PROJECT-17019011
[Patent] GPP synthase derived from Actinomycetes and method for producing GPP using it2005
- Inventor(s)
  Tomohisa Kuzuyama, Joseph P.Noel, Stephane B.Richard
- Industrial Property Rights Holder
  Toudai TLO, The Salk Institute for Biological Studies
- Filing Date
  2005-09-07
- Data Source
  KAKENHI-PROJECT-17019011
[Presentation] メロテルペノイドの生合成経路におけるプレニル基転移酵素Fur7の触媒機構の計算的研究2025
- Author(s)
  大村拓登, 趙凡，森脇由隆, 野口智弘, 白石太郎, 葛山智久, 寺田透
- Organizer
  日本化学会第105春季年会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 構造多様性一挙構築型生体反応の集積・予知・創出2025
- Author(s)
  葛山智久
- Organizer
  学術変革領域研究(A) 生体反応の集積・予知・創出を基盤としたシステム生物合成科学「予知生合成科学」第5 回公開シンポジウム
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] ジテルペン合成酵素を用いた3,7,18-ドラベラトリエンの化学－酵素ハイブリッド合成2025
- Author(s)
  遠藤聖也、中山淳、葛山智久、品田哲郎
- Organizer
  日本化学会第105春季年会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthesis of the nucleoside antibiotic A-949642025
- Author(s)
  Hao Xu, Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 核酸系抗生物質ヒキジマイシンの生合成に関する研究2025
- Author(s)
  井原雅盛、白石太郎、葛山智久
- Organizer
  日本農芸化学会2025年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 含ハロゲンテルペンアナログの化学-酵素ハイブリッド合成2025
- Author(s)
  福田瑛吾、黒崎飛優馬、前田尚輝、中山淳、葛山智久、品田哲郎
- Organizer
  日本化学会第105春季年会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Studies on terpene synthases from cyanobacteria2024
- Author(s)
  Jiayi Yu, Taro Shiraishi, Ayako Yoshida, Tomohisa Kuzuyama
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] プレニル基転移酵素を用いたプテロカルパン型天然物の化学酵素合成2024
- Author(s)
  三浦勇輝, 福田夢月, 白石太郎, 葛山智久, 小倉由資
- Organizer
  第 34 回イソプレノイド研究会例会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Studies on the biosynthesis of phenazine derivatives from Streptomyces purpeofuscus and S. prunicolor2024
- Author(s)
  Dan Xia, Qi Luo, Taro Shiraishi, Kazuo Shin-ya, Tomohisa Kuzuyama
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Unusual C-C bond-forming reactions in the biosynthesis of the nucleoside antibiotic A-949642024
- Author(s)
  Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  The 2nd Taiwan-Japan Bilateral Symposium on Natural Products Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 計算科学を用いた真菌由来テルペン環化酵素の反応機構解析2024
- Author(s)
  烏野祐作、佐藤　玄、白石太郎、葛山智久
- Organizer
  第24回蛋白質科学会年会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 計算科学を用いた真菌由来テルペン環化酵素の反応機構解析2024
- Author(s)
  烏野裕作, 佐藤玄, 白石太郎, 葛山智久
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Type II Polyketide Synthase-like Enzymes for Cispentacin Biosynthesis2024
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  2024 US-Japan Seminar on the Biosynthesis of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] ヒドロアルコキシ化を触媒するFur21の基質との複合体の構造予測および反応機構解析2024
- Author(s)
  青山直樹 , 白石太郎, 森脇由隆, 葛山智久, 寺田透
- Organizer
  第24回蛋白質科学会年会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 構造多様性一挙構築型生体反応の集積・予知・創出2024
- Author(s)
  葛山智久
- Organizer
  生体反応の集積・予知・創出を基盤としたシステム生物合成科学第3回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Discovery of Type II Polyketide Synthase-like Enzymes for Cispentacin Biosynthesis2024
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  3rd Japanese-German Symposium on the Biosynthesis of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 放線菌由来新規脱水酵素 Agm6 の基質認識の拡大2024
- Author(s)
  滝沢仁基, 白石太郎, 葛山智久
- Organizer
  第 38 回(2024 年度)日本放線菌学会大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 放線菌が生産する炭素五員環骨格含有天然化合物の探索2024
- Author(s)
  日比玄紀, 白石太郎, 葛山智久
- Organizer
  第 38 回(2024 年度)日本放線菌学会大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] カイトセファリンの生合成研究2024
- Author(s)
  前野優香理, 齋藤直也, 白石太郎, 小川哲弘, 丸山潤一, 新家一男 , 葛山智久
- Organizer
  日本農芸化学会2024年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Discovery of an unprecedented use of thiamine diphosphate in natural product biosynthesis2023
- Author(s)
  Yuxun ZHU, Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthetic Study on the Nucleoside Antibiotic Amipurimycin2023
- Author(s)
  Taro Shiraishi, Genki Hibi, Tatsuki Umemura, Hideo Ikeuchi, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  2023 The 1st Taiwan-Japan Bilateral Symposium on Natural Products Biosynthesis
- Invited
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Studies on Diterpene Synthases from Cyanobacteria2023
- Author(s)
  Jiayi Yu, Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  第33回イソプレノイド研究会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthesis of the acyl side chain in the nucleoside antibiotic A-94964 by unusual Type I polyketide synthase of Streptomyces sp. SANK 604042023
- Author(s)
  徐昊、白石太郎、葛山智久
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PROJECT-21H02127
[Presentation] 生体反応の集積・予知・創出を基盤としたシステム生物合成科学2023
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2023年度大会
- Invited
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 特殊アミノ酸シスペンタシン生合成の再構成を起点とした新規Ⅱ型ポリケチド生合成機構の解明2023
- Author(s)
  日比玄紀, 白石太郎, 梅村龍槻, 西山真, 葛山智久
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthesis of the acyl side chain in the nucleoside antibiotic A-94964 by unusual Type I polyketide synthase of Streptomyces sp. SANK 604042023
- Author(s)
  Hao Xu, Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  日本農芸化学会2023年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthesis of the nucleoside antibiotics angustmycins2023
- Author(s)
  Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthesis of the non-proteinogenic amino acid cispentacin in actinomycetes2023
- Author(s)
  Genki Hibi, Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  4th International Conference on Natural Product Discovery and Development in the Genomic Era
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] A C-C bond formation through the transfer of a Breslow intermediate between two distinct thiamine diphosphate-dependent enzymes2023
- Author(s)
  朱裕勛, 白石太郎, 伊藤篤朗, 小倉由資, 西山真, 葛山智久
- Organizer
  第65回天然有機化合物討論会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 構造多様性一挙構築型生体反応の集積・予知・創出2023
- Author(s)
  葛山智久
- Organizer
  学術変革領域研究（A）予知生合成科学第一回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthesis of the acyl side chain of the nucleotide antibiotic A-94964 produced by Streptomyces sp. SANK 604042022
- Author(s)
  徐昊、白石太郎、葛山智久
- Organizer
  2022年度本放線菌学会大会　福井
- Data Source
  KAKENHI-PROJECT-21H02127
[Presentation] Biosynthesis of phosphonothrixin produced by Saccharothrix sp. ST-8882022
- Author(s)
  Yuxun Zhu, Tomohisa Kuzuyama
- Organizer
  日本放線菌学会2022年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] ホスホノスリキシンの生合成に見出した二つのチアミンニリン酸依存性酵素は協働して炭素-炭素結合を形成する2022
- Author(s)
  朱裕勛, 葛山智久
- Organizer
  日本農芸化学会関東支部2022年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 放線菌由来非タンパク質性アミノ酸シスペンタシンの生合成機構2022
- Author(s)
  日比玄紀、白石太郎、葛山智久
- Organizer
  日本放線菌学会2022年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 特殊アミノ酸シスペンタシンの生産とその生合成機構の解析2022
- Author(s)
  日比玄紀, 梅村龍槻, 白石太郎, 西山真, 葛山智久
- Organizer
  日本農芸化学会関東支部2022年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] Biosynthesis of the acyl side chain of the nucleotide antibiotic A-94964 produced by Streptomyces sp. SANK 604042022
- Author(s)
  Hao Xu, Taro Shiraishi, Tomohisa Kuzuyama
- Organizer
  日本放線菌学会2022年度大会
- Data Source
  KAKENHI-PLANNED-22H05120
[Presentation] 複雑骨格を構築する生合成マシナリーの機能予知2021
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2021年度大会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 生合成の in vitro 再構成系を利用した新規 trichostatin 類縁体の創生2021
- Author(s)
  松田悠太郎、湯澤賢、青山美和子、大澤宏祐、吉田将人、土井隆行、新家一男、西山真、葛山智久
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] スクアレン合成酵素に似た放線菌由来芳香族プレニル基転移酵素の構造学的研究2021
- Author(s)
  永田隆平、末宗周憲、山本将輝、小林正弥、品田哲郎、西山真、永野真吾、葛山智久
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of the nucleoside-derived natural product angustmycin2021
- Author(s)
  Jiaqi XIA, Taro SHIRAISHI, Tomohisa KUZUYAMA
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] イソプレノイド生合成経路は新発見の宝庫2019
- Author(s)
  葛山　智久
- Organizer
  日本農芸化学会2019年度大会シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding Biochemical Mechanism in Natural Product Biosynthesis2019
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Genentech Lecture
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding Biochemical Mechanism in Terpenoid Biosynthesis2019
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  日中分野別ハイレベル研究者交流会2019：医薬・健康領域
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 生合成再設計を指向した天然化合物骨格形成機構の解明2019
- Author(s)
  葛山智久
- Organizer
  微生物ウィークシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 微生物の多様なイソプレノイド生合成機構2019
- Author(s)
  葛山智久
- Organizer
  琉球大学熱帯生物圏研究センター第5回 TBRCセミナー
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 複雑骨格を創成する革新的生合成マシナリーの開拓と精密機能解析2019
- Author(s)
  葛山智久
- Organizer
  新学術領域生合成リデザイン第７回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Unraveling the biosynthesis of the phosphonate antibiotic fosfomycin2018
- Author(s)
  葛山　智久
- Organizer
  1st German-Japanese Joint Symposium on the Biosynthesis of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Trichoderma属糸状菌由来Brasilane型セスキテルペン合成酵素の機能解析2018
- Author(s)
  寺本　和矢、野中　健一、塩見　和朗、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化反応に関する研究2018
- Author(s)
  葛山　智久
- Organizer
  日本応用酵素協会第44回研究発表会
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Activation of cryptic gene clusters led to the discovery of novel polyketides in Streptomyces2018
- Author(s)
  葛山　智久
- Organizer
  The 3rd A3 Foresight Symposium on Chemical & Synthetic Biology of Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] プレニルインドール化合物carquinostatin Aの生合成研究2018
- Author(s)
  小林　正弥、新家　一男、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 新規thioviridamide類縁体の創出と生合成酵素の機能解析2018
- Author(s)
  工藤　慧、小岩井　花恵、新家　一男、池田　治生、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding biochemical mechanism in natural product biosynthesis2018
- Author(s)
  葛山　智久
- Organizer
  Egypt/Japan Joint Seminar on Natural Products
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] ペプチジルヌクレオシド系抗生物質Amipurimycinの生合成に関する研究2018
- Author(s)
  池内　秀雄、白石　太郎、新家　一男、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 複雑骨格を創成する革新的生合成マシナリーの開拓と精密機能解析2018
- Author(s)
  葛山　智久
- Organizer
  新学術領域生合成リデザイン第5回公開シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化機構の解析2018
- Author(s)
  野口　智弘、工藤　慧、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 原核生物由来テルペン合成酵素の探索と解析2018
- Author(s)
  村井恵一、新家　一男、西山　真、葛山　智久
- Organizer
  日本農芸化学会2018年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Activation of cryptic gene clusters led to the discovery of novel polyketides in Streptomyces2017
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  JSPS-NRCT2017
- Place of Presentation
  バンコク（タイ）
- Year and Date
  2017-03-01
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 原核生物由来テルペン合成酵素の探索と解析2017
- Author(s)
  村井　恵一、新家　一男、西山　真、葛山　智久
- Organizer
  第27回イソプレノイド研究会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Investigating Biosynthetic of the Antituberculous Agent Caprazamycin2017
- Author(s)
  Taro Shiraishi, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] シクロラバンデュリル二リン酸合成酵素の結晶構造解析2017
- Author(s)
  小林正弥, 富田武郎, 品田哲郎, 西山真, 葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Elucidation of Multistep Reaction Cascade Catalyzed by the Diterpene Cyclase CotB22017
- Author(s)
  Kazuya Teramoto, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Discovery and biosynthetic characterization of a natural product biosynthesized via AmCP-mediated machinery2017
- Author(s)
  Matsuda, K., Hasebe, F., Shiwa, Y., Kanesaki, Y., Tomita, T., Yoshikawa, H., Shin-ya, K., Kuzuyama, T. Nishiyama, M.
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Novel Polyketides Discovered via Activation of Cryptic Genes from Streptomyces2017
- Author(s)
  Wei li Thong, Kazuo Shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化機構の解析2017
- Author(s)
  野口智弘、工藤慧、西山真、葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] カプラザマイシン生合成に関与する特異なメチル基転移酵素の機能解析2017
- Author(s)
  白石　太郎、五十嵐　雅之、西山真、葛山　智久
- Organizer
  日本放線菌学会2017年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding Biochemical Mechanism in Natural Product Biosynthesis2017
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  1st China-Japan Joint Symposium on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of a Histone Deacetylase Inhibitor Trichostatin A2017
- Author(s)
  Kudo K, Shin-ya, K, Nishiyama, M., Kuzuyama, K.
- Organizer
  Biosynthesis of a Histone Deacetylase Inhibitor Trichostatin A
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Structural Studies on the Biosynthesis of Cyclolavandulyl Skeleton Catalyzed by an Unprecedented Terpene Synthase2017
- Author(s)
  Masaya Kobayashi, Takeo Tomita, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of Prenylated Indole Alkaloids in Streptomyces2017
- Author(s)
  Masaya Kobayashi, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of the Nucleoside Antibiotic A-949642017
- Author(s)
  Shiraishi, T., Nishiyama, M., Kuzuyama, T.
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌のメロテルペノイド生合成における普遍的脱アミノ化機構の解析2017
- Author(s)
  野口智弘, 工藤慧, 西山真, 葛山智久
- Organizer
  日本放線菌学会2017年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] カプラザマイシン生合成における小タンパク質を介したアシル化反応の発見2017
- Author(s)
  白石太郎、廣昇、五十嵐雅之、西山真、葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Understanding biochemical mechanism in natural product biosynthesis2017
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Directing Biosynthesis V
- Place of Presentation
  コベントリー（英国）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Novel Polyketides Discovered via Activation of Cryptic Genes from Streptomyces2017
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  US-Japan Seminar on the Biosynthesis of Natural Products for Young Researchers
- Place of Presentation
  東京工業大学（東京都目黒区）
- Year and Date
  2017-03-04
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 複雑骨格を創成する革新的生合成マシナリーの開拓と精密機能解析2017
- Author(s)
  葛山智久
- Organizer
  新学術領域「生合成リデザイン」第一回公開シンポジウム
- Place of Presentation
  東京大学（東京都文京区）
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] プレニルインドール化合物carquinostatin Aの生合成研究2017
- Author(s)
  小林　正弥,　新家　一男,　西山　真,　葛山　智久
- Organizer
  日本放線菌学会2017年度大会
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Trichoderma属糸状菌由来テルペン合成酵素の探索と機能解析2017
- Author(s)
  寺本和矢、石神健、野中健一、塩見和朗、西山真、葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府京都市）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthetic Origin of the Hydroxamic Acid Moiety of Trichostatin A: Identification of Unprecedented Enzymatic Machinery Involved in Hydroxylamine Transfer2017
- Author(s)
  Kei Kudo, Taro Ozaki, Kazuo Shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  International Symposium on Biology of Actinomycetes
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Mechanistic insights into terpene cyclization reactions2017
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  U.S./Japan Seminar on Natural Product Biosynthesis
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Isolation of isoindolinomycin, a novel isoindolinone-derived natural product discovered via activation of cryptic gene cluster from Streptomyces2017
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] ペプチジルヌクレオシド系抗生物質Amipurimycinの生合成に関する研究2017
- Author(s)
  池内秀雄,　新家一男　西山真,　葛山智久
- Organizer
  日本農芸化学会2017年度大会
- Place of Presentation
  京都女子大学（京都府東山区）
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] シクロラバンデュリル2リン酸合成酵素の結晶構造解析2016
- Author(s)
  小林正弥、富田武郎、品田哲郎、西山真、葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  長崎シーボルト大学（長崎県西彼杵郡）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌のテルペノイド生合成機構に関する研究2016
- Author(s)
  葛山智久
- Organizer
  北里大学受賞講演会
- Place of Presentation
  北里大学（東京都港区）
- Year and Date
  2016-01-29
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] テルペンに関する最近の話題2016
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-27
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Bacillus alcalophilus由来セスタテルペン/トリテルペン合成酵素ホモログの機能解析2016
- Author(s)
  田中慧里奈、石神健、富田武郎、西山真、葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  長崎シーボルト大学（長崎県西彼杵郡）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来ジテルペン環化酵素CotB2が触媒する精巧な環化反応機構の解明2016
- Author(s)
  寺本和矢、目黒亜由子、本吉祐大、佐藤玄、増本優衣、手塚則亨、坂井健太、上田翔太、遠塚悠輔、安藤祐美、富田武郎、金承榮、木村智之、五十嵐雅之、澤竜一、品田哲郎、王超、内山真伸、西山真、葛山智久
- Organizer
  日本農芸化学会2016年度大会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 微生物由来テルペノイドの生合成研究2016
- Author(s)
  葛山智久
- Organizer
  住木・梅澤記念賞受賞講演会
- Place of Presentation
  学士会館（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] アシル化反応に関与する新奇キャリアタンパク質の発見2016
- Author(s)
  白石太郎、廣昇、五十嵐雅之、西山真、葛山智久
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] ジテルペン環化酵素が触媒する多段階反応機構の解明2016
- Author(s)
  寺本和矢、目黒亜由子、本吉祐大、佐藤玄、増本優衣、手塚則亨、坂井健太、上田翔太、遠塚悠輔、安藤祐美、富田武郎、金承榮、木村智之、五十嵐雅之、澤竜一、品田哲郎、王超、内山真伸、西山真、葛山智久
- Organizer
  天然有機化合物討論会
- Place of Presentation
  東北大学（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来新奇テルペン環化酵素の結晶構造解析2016
- Author(s)
  小林正弥、尾﨑太郎、富田武郎、西山真、葛山智久
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Structural and biochemical studies of cytidylyltransferase involved in the biosynthesis of the phosphonate-antibiotic fosfomycin2016
- Author(s)
  Cho, Su-Hee, Kuzuyama, T.
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of novel polyketides discovered via activation of cryptic genes from Streptomyces2016
- Author(s)
  Thong, Wei-li, Kuzuyama, T.
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Biosynthesis of the antituberculous agent caprazamycin2016
- Author(s)
  Taro Shiraishi, Makoto Nishiyama and Tomohisa Kuzuyama
- Organizer
  2016 SIMB Annual Meeting and Exhibition
- Place of Presentation
  ニューオーリンズ（米国）
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 放線菌由来環状天然化合物の骨格形成機構2016
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2016年度第一回関東支部例会
- Place of Presentation
  東京農業大学（東京都世田谷区）
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌の生産するヌクレオシド系抗結核性抗生物質に関する研究2016
- Author(s)
  葛山智久
- Organizer
  HiHA 第８回 Workshop「代謝と健康」
- Place of Presentation
  広島大学（広島県東広島市）
- Invited
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] 微生物由来テルペノイドの生合成研究2016
- Author(s)
  葛山智久
- Organizer
  住木・梅澤記念賞受賞講演
- Place of Presentation
  学士会館（東京都千代田区）
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Studies on the Biosynthesis of the Peptidyl Nucleoside Antibiotic Amipurimycin2016
- Author(s)
  池内秀雄、新家一男、西山真、葛山智久
- Organizer
  日本放線菌学会2016年度大会
- Place of Presentation
  東京大学（東京都文京区）
- Year and Date
  2016-09-08
- Data Source
  KAKENHI-PLANNED-16H06453
[Presentation] Trichoderma属糸状菌由来モノテルペン合成酵素の探索と機能解析2016
- Author(s)
  寺本和矢、石神健、野中健一、塩見和朗、西山真、葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  長崎シーボルト大学（長崎県西彼杵郡）
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] アリル基質同士の縮合と環化反応を触媒する新奇テルペン合成酵素の発見 ○小林正弥, 尾﨑太郎1, 趙平1,富田武郎, 苅田祐馬, 保野陽子, 西村栄治, 品田哲郎, 西山真, 葛山智久2015
- Author(s)
  小林正弥, 尾﨑太郎, 趙平, 富田武郎, 苅田祐馬, 保野陽子, 西村栄治, 品田哲郎, 西山真, 葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来ジテルペン環化酵素CotB2の特異な環化反応機構の解明2015
- Author(s)
  寺本和矢, 目黒亜由子, 本吉祐大, 上田翔太, 遠塚悠輔, 安藤祐美, 坂井健太,富田武郎, 金承榮, 木村智之, 五十嵐雅之, 澤竜一, 品田哲郎, 西山真, 葛山智久
- Organizer
  イソプレノイド研究会
- Place of Presentation
  東北大学（宮城県仙台市）
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌のテルペノイド生合成機構に関する研究2015
- Author(s)
  葛山智久
- Organizer
  日本放線菌学会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-07
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of terpenoids produced by Streptomyces2015
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  2015 KMB International Symposium & Annual Meeting
- Place of Presentation
  全州（韓国）
- Year and Date
  2015-06-24
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] ゲラニルファルネソールおよびファルネシルファルネソールの合成研究2015
- Author(s)
  石神健、葛山智久、渡邉秀典
- Organizer
  香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  近畿大学（大阪府東大阪市）
- Year and Date
  2015-09-05
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Bacterial Indole Prenyltransferases for Chemoenzymatic Synthesis of Prenylated Compounds2015
- Author(s)
  Intan Timur Maisyarah, Kazuo shin-ya, Makoto Nishiyama, Tomohisa Kuzuyama
- Organizer
  日本放線菌学会
- Place of Presentation
  富山国際会議場（富山県富山市）
- Year and Date
  2015-09-07
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 多様なイソプレノイド生合成機構とその関連遺伝子2015
- Author(s)
  葛山智久
- Organizer
  千葉工大フォーラム
- Place of Presentation
  千葉工業大学（千葉県習志野市）
- Year and Date
  2015-06-19
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] イソプレノイド生合成経路の収斂進化2015
- Author(s)
  葛山智久
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] An Unusual Terpene Cyclization Mechanism Involving a Carbon－Carbon Bond Rearrangement2015
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  TERPNET2015
- Place of Presentation
  バンクーバー（カナダ）
- Year and Date
  2015-06-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来テルペノイド生合成マシナリーの解明2014
- Author(s)
  葛山智久
- Organizer
  科研費新学術領域「生合成マシナリー」第８回公開シンポジウム
- Place of Presentation
  東京大学薬学部講堂（東京都文京区）
- Year and Date
  2014-12-06
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of anti-influenza virus diterpene wickerols and other terpenoids produced by Trichoderma atroviride FKI-38492014
- Author(s)
  寺本和矢、西山真、葛山智久
- Organizer
  第14回東京大学生命科学シンポジウム
- Place of Presentation
  東京大学伊藤国際学術研究センター（東京都文京区）
- Year and Date
  2014-04-26
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of anti-influenza virus diterpene wickerols and other terpenoids produced by Trichoderma atroviride FKI-38492014
- Author(s)
  寺本和矢、西山真、葛山智久
- Organizer
  第3回生物生産工学研究センター研究発表会
- Place of Presentation
  東京大学農学部一条ホール（東京都文京区）
- Year and Date
  2014-04-22
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] Biosynthesis of terpenoids produced by Streptomyces2014
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Simposium Nasional Kimia Bahan Alam XXII
- Place of Presentation
  バンドン（インドネシア）
- Year and Date
  2014-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] 放線菌由来環状天然化合物の骨格形成機構の解明2014
- Author(s)
  葛山智久
- Organizer
  生物生産工学研究センターシンポジウム
- Place of Presentation
  東京大学農学部一条ホール（東京都文京区）
- Year and Date
  2014-12-08
- Invited
- Data Source
  KAKENHI-PROJECT-26292058
[Presentation] メバロン酸経路の新規初発反応と反応機構の解明2010
- Author(s)
  岡村英治、富田武郎、澤竜一、西山真、葛山智久
- Organizer
  第52回天然有機化合物討論会
- Place of Presentation
  静岡県コンベンションアーツセンター(静岡県)
- Year and Date
  2010-09-30
- Data Source
  KAKENHI-PROJECT-21380071
[Presentation] Functional characterization of Streptomyces ABBA prenyltransferases in the biosyntheses of naphthoquinone derivatives and novobiocin2010
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  60^<th> SIM Annual Meeting
- Place of Presentation
  San Francisco Convention Center (USA)(招待講演)
- Year and Date
  2010-08-03
- Data Source
  KAKENHI-ORGANIZER-22108001
[Presentation] 放線菌のメバロン酸経路遺伝子クラスターに見出した新規チオラーゼスーパーファミリー2010
- Author(s)
  葛山智久
- Organizer
  日本農芸化学会2010年度大会シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-21380071
[Presentation] Unusual cyclization mechanism of Streptomyces terpene cyclases
- Author(s)
  Tomohisa Kuzuyama
- Organizer
  Natural Product Discovery in the Post Genomic Era
- Place of Presentation
  サンディエゴ（米国）
- Year and Date
  2015-01-11 – 2015-01-15
- Invited
- Data Source
  KAKENHI-PROJECT-26292058

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52. 勝山陽平 (50646437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 大栗博毅 (80311546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 淡川孝義 (80609834)

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# of Collaborated Products: 0 results
55. 荘司長三 (90379587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
56. 吉田彩子 (90633686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
57. 小川哲弘 (40323480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
58. MATHIS D.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
59. BENOIST C

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
60. PIATIGORSKY ジェイ

# of Collaborated Projects: 1 results

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61. MARTY J.L.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
62. THOMPSON C.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
63. GOSSLER A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
64. 降旗圭子

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
65. LUO QI

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66. KOMATSU Mamoru

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# of Collaborated Products: 1 results
67. 品田哲郎

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# of Collaborated Products: 2 results
68. 清水謙多郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuzuyama Tomohisa 葛山 智久

KUZUYAMA Tomohisa 葛山 智久

Research Projects

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Systems biosynthetics based on accumulation, prediction, and creation of biological reactionsArea Organizer

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予知生合成科学・研究総括班Principal Investigator

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構造多様性一挙構築型生体反応の集積・予知・創出Principal Investigator

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Creation of Innovative Nucleic Acid-Based Compounds by Redesigning Biosynthetic MachineryPrincipal Investigator

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Exploratory research for innovative terpene synthases without existing motif sequencesPrincipal Investigator

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メロテルペノイド生合成マシナリーの機能と構造に関する研究Principal Investigator

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Redesigning Biosynthetic Machineries (Project Team)

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Development and precise functional analysis of innovative biosynthetic machinery to create complex skeletonsPrincipal Investigator

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Redesigning Biosynthetic Machineries (International Activity Support Team)

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Reaction mechanism of unique terpene synthases, that is elucidated by synthetic chemistry and structural biologyPrincipal Investigator

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Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites

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テルペンおよびヌクレオシド系抗生物質生合成マシナリーの解明とエンジニアリングPrincipal Investigator

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Search for anti-malaria agents from marine organisms

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Kuzuyama Tomohisa 葛山智久

KUZUYAMA Tomohisa 葛山智久