Tomita Taisuke 富田泰輔

… Alternative Names

TOMITA Taisuke 富田泰輔

Less

Researcher Number	30292957
Other IDs	https://orcid.org/0000-0002-0075-5943
Affiliation (Current)	2024: 東京大学, 大学院薬学系研究科(薬学部), 教授
Affiliation (based on the past Project Information) *help	2015 – 2024: 東京大学, 大学院薬学系研究科(薬学部), 教授 2016: 東京大学, 大学院薬学系研究科, 教授 2016: 東京大学, 大学院薬学系研究科, 教授 2015: 東京大学, 薬学部, 准教授 2014 – 2015: 東京大学, 薬学研究科(研究院), 教授 … More 2012 – 2013: 東京大学, 薬学研究科(研究院), 准教授 2007 – 2012: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Associate professor 2008: 東大, 薬学研究科(研究院), 准教授 2007: The University of Tokyo, 大学院・薬学研究科, 准教授 2006: 東京大学, 大学院薬学系研究科, 助教授 2005: 東京大学, 大学院・薬学系研究科, 講師 2004: 東大, 薬学研究科(研究院), 講師 2003: The University of Tokyo, Graduate School of Pharmaceutical Sciences, Lecturer, 大学院・薬学系研究科, 講師 1998 – 2002: 東京大学, 大学院・薬学系研究科, 助手 2001: 東京大学, 大学院・薬学研究科, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biological pharmacy / Biological Sciences / Biological pharmacy / Pharmaceutical Sciences and related fields / Pathological medical chemistry / Pharmacology in pharmacy Except Principal Investigator Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology / Biological Sciences / Neurology
Keywords	Principal Investigator アルツハイマー / セクレターゼ / アミロイド / 認知症 / 脳神経疾患 / 神経変性疾患 / シナプス / アルツハイマー病 / プロテアーゼ / アミロイドβ … More / 膜内配列切断 / βアミロイド / プレセニリン / ストレス応答 / タウ / 凝集タンパク質 / タンパク質凝集 / 接着分子 / 神経細胞 / 酵素 / 薬学 / タンパク分解 / オートファジー / ストレス顆粒 / 細胞内温度 / 相分離 / 細胞連関 / 機能連関 / プロテオミクス / セクレトーム / バルプロ酸 / 自閉症 / グリア細胞 / 神経変性 / 触媒 / 光反応 / 光触媒 / ゲノム編集 / CRIPSR / 凝集 / CRISPR/Cas9 / CRIPSR/Cas9 / 先制医療 / モデル動物 / リスク因子 / Intramembrane proteolysis / Amyloid / Secretase / Alzheimer's disease / 単粒子解析法 / 細胞内輸送 / ウイルス発現系 / RNA干渉法 / 分子生物学 / セレクターゼ / EphA4 / アストロサイト / 受容体 / スフィンゴシン1リン酸 / 分解 / バイオテクノロジー / 構造解析 / ケミカルバイオロジー / 生理活性 / 機能抗体 / Notch / γセクレターゼ / 老化 / 神経化学 / 痴呆 … More Except Principal Investigator アルツハイマー病 / βアミロイド / Alzheimer / アルツハイマー / γ-secretase / プレセニリン / α-Synuclein / Lewy小体型痴呆症 / パーキンソン病 / Amyloid-beta / APP / Sphingosine-1-phosphate / Sphingosine kinase / アストロサイト / スフィンゴシン-１-リン酸 / アポリポプロテインE / スフィンゴシン-1-リン酸 / スフィンゴシンキナーゼ / アミロイドβ / 脂質代謝酵素 / SphK2 / S1P / ウイルスベクター / 脳分子プロファイル / モデル動物 / 脳画像データベース / ブレインバンク / 技術開発支援 / 研究リソース支援 / 若手研究者育成支援 / 技術開発 / 研究リソース / 研究集会 / 研究支援 / 脳科学 / β-amyloid / Presenilin / γセレクターゼ / γセクレターゼ / amyloid / collagen / CLAC / 膜結合型コラーゲン / neuronal death / ubiquitination / phosphorylation / Lewy body / a-synuclein / Parkinson's disease / 神経変性疾患 / Lewy小体痴呆症 / αシヌクレイン / 老化 / 脳神経疾患 / 神経科学 / 神経細胞化 / ユビキチン化 / リン酸化 / Lewy小体 / α-シヌクレイン / amyloid β peptide / presenilin / Alzheimer's disease / Aβ42 / 髄液診断 / 生化学マーカー Less

中枢神経系プロテイノパチー発症機構の統合的解明Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Elucidation of the mechanism of TDP-43 dynamics regulated by intracellular temperaturePrincipal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Elucidation of the role of autophagy in photo-oxygenated amyloid degradationPrincipal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Elucidation of Molecular Pathogenesis Leading to Abnormal Synapse Formation in the Pathogenesis of AutismPrincipal Investigator
- Principal Investigator
  
  Tomita Taisuke
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Elucidation of Cellular Pathogenesis as a Key Mechanism for Neurodegenerative Processes in the Pathogenesis of DementiaPrincipal Investigator
- Principal Investigator
  
  Tomita Taisuke
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Spatial and temporal control of intracellular aggregates by photo-oxygenation catalystPrincipal Investigator
- Principal Investigator
  
  Tomita Taisuke
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  The University of Tokyo
Identification of genetic regulators for intracellular aggregation by genome-wide CRISPR screeningPrincipal Investigator
- Principal Investigator
  
  Tomita Taisuke
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokyo
Development of preemptive medicine based on the molecular mechanism of risk factors for Alzheimer diseasePrincipal Investigator
- Principal Investigator
  
  Tomita Taisuke
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
炎症反応に呼応する神経外環境因子によるアミロイドβタンパク代謝制御機構の解明Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Elucidation of molecular mechanisms for synaptic homeostasis regulated by monoaminergic neurotransmittersPrincipal Investigator
- Principal Investigator
  
  TOMITA Taisuke
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pharmacology in pharmacy
- Research Institution
  The University of Tokyo
Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signaling
- Principal Investigator
  
  TAKASUGI NOBUMASA
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Okayama University
  Juntendo University
神経炎症反応によって制御される脳内アミロイド代謝システムの分子機構Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Alterations of proteolytic processing of synaptic adhesion molecules in Alzheimer diseasePrincipal Investigator
- Principal Investigator
  
  TOMITA Taisuke
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Comprehensive Brain Science Network
- Principal Investigator
  
  Kimura Minoru
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Center for Novel Science Initatives, National Institutes of Natural Sciences
膜マイクロドメイン局在化とγセクレターゼ活性制御機構の解明Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
創薬標的分子としての新規γセクレターゼ活性制御因子群の解析Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
γセクレターゼの基質特異性に関する分子機構の解明Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Discovery for mechanism-based drugs for Alzheimer's disease by chemical biologyPrincipal Investigator
- Principal Investigator
  
  TOMITA Taisuke
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (S)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
膜内配列切断機構の理解による新規アルツハイマー病創薬標的因子の探索Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
神経細胞シナプス形成機構におけるNotchシグナルの解明Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Molecular analysis of intramembrane proteolysis by combinatorial reconstitution and chemical genetics of membrane protein complex.Principal Investigator
- Principal Investigator
  
  TOMITA Taisuke
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
γセクレターゼによる膜内配列切断・分解機構の解明Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
アルツハイマー病発症機構におけるプレセニリンとγセクレターゼの機能解析Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Analysis of presenilin/γ-secretase complex responsible for the generation of Aβ in Alzheimer's disease
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The University of Tokyo
家族性アルツハイマー病原因遺伝子プレセニリンの機能解析Principal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
脳脊髄液中α-synuclein微量測定による神経変性疾患診断方法開発の試み
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  The University of Tokyo
Title "Molecular Pathogenesis of Parkinson's Disease"
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tokyo
Development of diagnostic and therapeutic strategies for Alzheimer's disease : focus on a novel cerebral amyloid component
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The University of Tokyo
アルツハイマー病発症におけるプレセニリンの意義についてPrincipal Investigator
- Principal Investigator
  
  富田泰輔
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
MOLECULAR PATHOLOGICAL STUDIE OF ALZHEIMER'S DISEASE : ROLE OF β-AMYLOID AND PRESENILINS
- Principal Investigator
  
  IWATSUBO Takeshi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  UNIVERSITY OF TOKYO

[Book] Aβ線維の構造2022
- Author(s)
  富田泰輔
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 神経変性疾患研究の計画的セレンディピティ2022
- Author(s)
  富田泰輔
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] アルツハイマー病治療の新たなストラテジー2022
- Author(s)
  富田泰輔
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 脳神経内科2020
- Author(s)
  富田泰輔
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 認知症の最新医療11巻1号2020
- Author(s)
  富田泰輔
- Total Pages
  5
- Publisher
  フジメディカル出版
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] Geriatric Medicine（老年医学）2020
- Author(s)
  堀由起子、富田泰輔
- Total Pages
  5
- Publisher
  ライフ・サイエンス
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 医学のあゆみ273巻1号2020
- Author(s)
  富田泰輔
- Total Pages
  6
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 医学のあゆみ274巻12号2020
- Author(s)
  竹本亮太、高鳥翔、富田泰輔
- Total Pages
  2
- Publisher
  医歯薬出版
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 実験医学2019年4月号2019
- Author(s)
  富田　泰輔
- Total Pages
  145
- Publisher
  羊土社
- ISBN
  9784758125185
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 分子細胞生物学　第8版2019
- Author(s)
  H. Lodishほか、榎森　康文、堅田　利明、須藤　和夫、富田　泰輔、仁科　博史、山本　啓一
- Total Pages
  1108
- Publisher
  東京化学同人
- ISBN
  9784807909766
- Data Source
  KAKENHI-PROJECT-19H01015
[Book] 実験医学2019年4月号2019
- Author(s)
  富田　泰輔
- Total Pages
  145
- Publisher
  羊土社
- ISBN
  9784758125185
- Data Source
  KAKENHI-PROJECT-15H02492
[Book] 自閉症に関連するタンパク質 Neuroligin の神経活動に依存的な代謝はニューロンのシナプス形成を制御しているライフサイエンス新着論文レビュー2012
- Author(s)
  富田泰輔、鈴木邦道
- Data Source
  KAKENHI-PROJECT-24659028
[Book] シナプス接着分子neuroligin-1の神経活動依存的なタンパク質切断2012
- Author(s)
  鈴木邦道、富田泰輔、岩坪威
- Publisher
  実験医学vol31
- Data Source
  KAKENHI-PROJECT-24659028
[Book] アルツハイマー病治療薬創出に向けたγセクレターゼの構造解析と機能制御蛋白質核酸酵素2009
- Author(s)
  富田泰輔
- Data Source
  KAKENHI-PROJECT-19679001
[Book] アルツハイマー病治療薬創出に向けたγセクレターゼの構造解析と機能制御蛋白質核酸酵素2009
- Author(s)
  富田泰輔
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE.2023
- Author(s)
  Gao Y, Sun Y, Islam S, Nakamura T, Tomita T, Zou K, Michikawa M
- Journal Title
  
  Front Aging Neurosci
  
  Volume: 15 Pages: 1098034-1098034
- DOI
  10.3389/fnagi.2023.1098034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07352, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20K07861
[Journal Article] ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-7112023
- Author(s)
  Matsuzaki Masaya、Yokoyama Miyabishara、Yoshizawa Yota、Kaneko Naoki、Naito Hiroki、Kobayashi Honoka、Korenaga Akihito、Sekiya Sadanori、Ikemura Kentaro、Opoku Gabriel、Hirohata Satoshi、Iwamoto Shinichi、Tanaka Koichi、Tomita Taisuke
- Journal Title
  
  Molecular Psychiatry
  
  Volume: - Issue: 4 Pages: 1-11
- DOI
  10.1038/s41380-023-01946-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20H00548, KAKENHI-PROJECT-22J14778
[Journal Article] Pathogenic <scp>LRRK2</scp> compromises the subcellular distribution of lysosomes in a <scp>Rab12‐RILPL1</scp> ‐dependent manner2023
- Author(s)
  Ito Kyohei、Araki Miho、Katai Yuta、Nishimura Yuki、Imotani Sota、Inoue Haruki、Ito Genta、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 37 Issue: 5
- DOI
  10.1096/fj.202200780rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model2023
- Author(s)
  Iguchi Akihiro、Takatori Sho、Kimura Shingo、Muneto Hiroki、Wang Kai、Etani Hayato、Ito Genta、Sato Haruaki、Hori Yukiko、Sasaki Junko、Saito Takashi、Saido Takaomi C.、Ikezu Tsuneya、Takai Toshiyuki、Sasaki Takehiko、Tomita Taisuke
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 4 Pages: 106375-106375
- DOI
  10.1016/j.isci.2023.106375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06558, KAKENHI-PROJECT-22K07344, KAKENHI-PLANNED-22H05036, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21H02680, KAKENHI-PROJECT-21J13397, KAKENHI-PROJECT-22KJ0968
[Journal Article] Soluble form of the APP fragment, sAPPβ, positively regulates tau secretion2023
- Author(s)
  Sato Haruaki、Kasuga Kensaku、Isoo Noriko、Hayashi Toshihiro、Ikeuchi Takeshi、Hori Yukiko、Tomita Taisuke
- Journal Title
  
  Neuroscience Research
  
  Volume: - Pages: 63-70
- DOI
  10.1016/j.neures.2023.03.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07744, KAKENHI-PLANNED-22H05036, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-22KJ0968
[Journal Article] Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease2022
- Author(s)
  Kaneshiro Nanaka、Komai Masato、Imaoka Ryosuke、Ikeda Atsuya、Kamikubo Yuji、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Hashimoto Tadafumi、Iwatsubo Takeshi、Sakurai Takashi、Uehara Takashi、Takasugi Nobumasa
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 3 Pages: 103869-103869
- DOI
  10.1016/j.isci.2022.103869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21H02815, KAKENHI-PROJECT-19J22442, KAKENHI-PROJECT-20K07014, KAKENHI-PROJECT-20K07765, KAKENHI-PROJECT-21K07270
[Journal Article] Photo-Oxygenation as a New Therapeutic Strategy for Neurodegenerative Proteinopathies by Enhancing the Clearance of Amyloid Proteins2022
- Author(s)
  Tomizawa Ikumi、Nakagawa Hanako、Sohma Youhei、Kanai Motomu、Hori Yukiko、Tomita Taisuke
- Journal Title
  
  Frontiers in Aging Neuroscience
  
  Volume: 14
- DOI
  10.3389/fnagi.2022.945017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-23K21357
[Journal Article] The atypical Rab GTPase associated with Parkinson’s disease, Rab29, is localized to membranes2022
- Author(s)
  Nagai-Ito Yuki、Xu Lejia、Ito Kyohei、Kajihara Yotaro、Ito Genta、Tomita Taisuke
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 298 Issue: 10 Pages: 102499-102499
- DOI
  10.1016/j.jbc.2022.102499
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06558, KAKENHI-PROJECT-19H01015
[Journal Article] Promotion in the Clearance of Aggregated Aβ In Vivo Using Amyloid Selective Photo-Oxygenation Technology2022
- Author(s)
  Hori Yukiko、Sohma Youhei、Kanai Motomu、Tomita Taisuke
- Journal Title
  
  Neuroscience Insights
  
  Volume: 17
- DOI
  10.1177/26331055221126179
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-23K21357
[Journal Article] Specific Mutations in Aph1 Cause γ-Secretase Activation2022
- Author(s)
  Watanabe Hikari、Yoshida Chika、Hidaka Masafumi、Ogawa Tomohisa、Tomita Taisuke、Futai Eugene
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 507-507
- DOI
  10.3390/ijms23010507
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06558, KAKENHI-PROJECT-19H01015
[Journal Article] A red fluorescent genetically encoded biosensor for extracellular L-lactate2022
- Author(s)
  Nasu Yusuke、Kamijo Yuki、Hashizume Rina、Sato Haruaki、Hori Yukiko、Tomita Taisuke、Drobizhev Mikhail、Campbell Robert E.
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.08.30.505811
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-22KJ0968, KAKENHI-PROJECT-21K14738
[Journal Article] Mouse Models of Alzheimer’s Disease2022
- Author(s)
  Yokoyama Miyabishara、Kobayashi Honoka、Tatsumi Lisa、Tomita Taisuke
- Journal Title
  
  Frontiers in Molecular Neuroscience
  
  Volume: 15
- DOI
  10.3389/fnmol.2022.912995
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis2022
- Author(s)
  Sadequl Islam, Yang Sun, Yuan Gao, Tomohisa Nakamura, Arshad Ali Noorani, Tong Li, Philip C Wong, Noriyuki Kimura, Etsuro Matsubara, Kensaku Kasuga, Takeshi Ikeuchi, Taisuke Tomita, Kun Zou, Makoto Michikawa
- Journal Title
  
  J Neurosci
  
  Volume: 42 Issue: 8 Pages: 1574-1586
- DOI
  10.1523/jneurosci.2039-21.2021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07846, KAKENHI-PROJECT-19K07916, KAKENHI-PROJECT-19H01015
[Journal Article] 母体免疫活性化と自閉症スペクトラム障害2021
- Author(s)
  吉田文明、富田泰輔
- Journal Title
  
  生体の科学
  
  Volume: 72 Pages: 423-425
- Data Source
  KAKENHI-PROJECT-20K21471
[Journal Article] The Regulation of Rab GTPases by Phosphorylation2021
- Author(s)
  Xu Lejia、Nagai Yuki、Kajihara Yotaro、Ito Genta、Tomita Taisuke
- Journal Title
  
  Biomolecules
  
  Volume: 11 Issue: 9 Pages: 1340-1340
- DOI
  10.3390/biom11091340
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21K06558
[Journal Article] GPR120 signaling controls amyloid-β degrading activity of matrix metalloproteinases2021
- Author(s)
  Kazunori Kikuchi, Takuya Tatebe, Yuki Sudo, Miyabishara Yokoyama, Kiwami Kidana, Yung Wen Chiu, Sho Takatori, Makoto Arita, Yukiko Hori, Taisuke Tomita
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 41(28) Issue: 28 Pages: 6173-6185
- DOI
  10.1523/jneurosci.2595-20.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07080, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20H00495, KAKENHI-PROJECT-23K21357
[Journal Article] 母体免疫活性化と自閉症スペクトラム障害2021
- Author(s)
  吉田文明、富田泰輔
- Journal Title
  
  生体の科学
  
  Volume: 72 Pages: 423-725
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in the brains of Alzheimer’s disease model mice2021
- Author(s)
  Ozawa S, Hori Y, Shimizu Y, Taniguchi A, Suzuki T, Wang W, Chiu YW, Koike R, Yokoshima S, Fukuyama T, Takatori S, Sohma Y, Kanai M, Tomita T
- Journal Title
  
  Brain
  
  Volume: - Issue: 6 Pages: 1884-1897
- DOI
  10.1093/brain/awab058
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K07080, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20H00489
[Journal Article] Dietary cis-9, trans-11-conjugated linoleic acid reduces amyloid β-protein accumulation and upregulates anti-inflammatory cytokines in an Alzheimer's disease mouse model2021
- Author(s)
  Yu Fujita, Kuniyuki Kano, Shigenobu Kishino, Toshihiro Nagao, Xuefeng Shen, Chiharu Sato, Hatsune Hatakeyama, Yume Ota, Sho Niibori, Ayako Nomura, Kota Kikuchi, Wataru Yasuno, Sho Takatori, Kazunori Kikuchi, Yoshitake Sano, Taisuke Tomita, Toshiharu Suzuki, Junken Aoki, Kun Zou, Shunji Natori, Hiroto Komano
- Journal Title
  
  Scientific Reports
  
  Volume: 11(1) Issue: 1 Pages: 9749-9749
- DOI
  10.1038/s41598-021-88870-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07080, KAKENHI-PROJECT-19H01015
[Journal Article] Human tauopathy-derived tau strains determine the substrates recruited for templated amplification2021
- Author(s)
  Tarutani Airi、Miyata Haruka、Nonaka Takashi、Hasegawa Kazuko、Yoshida Mari、Saito Yuko、Murayama Shigeo、Robinson Andrew C、Mann David M A、Tomita Taisuke、Hasegawa Masato
- Journal Title
  
  Brain
  
  Volume: - Issue: 8 Pages: 2333-2348
- DOI
  10.1093/brain/awab091
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16482, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-16H06277
[Journal Article] Sequential conformational changes in transmembrane domains of presenilin 1 in Aβ42 downregulation2021
- Author(s)
  Cai Tetsuo、Tomita Taisuke
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Issue: 2 Pages: 215-227
- DOI
  10.1093/jb/mvab033
- NAID
  40022722309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Suppression of amyloid‐β secretion from neurons by cis‐9,trans‐11‐octadecadienoic acid, an isomer of conjugated linoleic acid2021
- Author(s)
  Hata Saori、Kano Kuniyuki、Kikuchi Kazunori、Kinoshita Shoichi、Sobu Yuriko、Saito Haruka、Saito Takashi、Saido Takaomi C.、Sano Yoshitake、Taru Hidenori、Aoki Junken、Komano Hiroto、Tomita Taisuke、Natori Shunji、Suzuki Toshiharu
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: 159 Issue: 3 Pages: 603-617
- DOI
  10.1111/jnc.15490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice2021
- Author(s)
  Miho Araki, Kyohei Ito, Sho Takatori, Genta Ito, Taisuke Tomita
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 30(17) Issue: 17 Pages: 1618-1631
- DOI
  10.1093/hmg/ddab146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07080, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21K06558
[Journal Article] セクレターゼ阻害薬の現状2021
- Author(s)
  富田泰輔
- Journal Title
  
  認知症の最新医療
  
  Volume: 11 Pages: 185-189
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Catalytic photooxygenation degrades brain Aβ in vivo2021
- Author(s)
  Nagashima Nozomu、Ozawa Shuta、Furuta Masahiro、Oi Miku、Hori Yukiko、Tomita Taisuke、Sohma Youhei、Kanai Motomu
- Journal Title
  
  Science Advances
  
  Volume: 7 Issue: 13 Pages: 0-1
- DOI
  10.1126/sciadv.abc9750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-19J14873, KAKENHI-PROJECT-20J22142, KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K22484, KAKENHI-PROJECT-20H00489
[Journal Article] Seeded assembly in vitro does not replicate the structures of α‐synuclein filaments from multiple system atrophy2021
- Author(s)
  Lovestam Sofia、Schweighauser Manuel、Matsubara Tomoyasu、Murayama Shigeo、Tomita Taisuke、Ando Takashi、Hasegawa Kazuko、Yoshida Mari、Tarutani Airi、Hasegawa Masato、Goedert Michel、Scheres Sjors H. W.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 11 Issue: 4 Pages: 999-1013
- DOI
  10.1002/2211-5463.13110
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16482, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-19K07988, KAKENHI-PROJECT-16H06277
[Journal Article] Detection of Substrate Phosphorylation of in Tissues and Cultured Cells2021
- Author(s)
  Ito Kyohei、Xu Lejia、Ito Genta、Tomita Taisuke
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1 Pages: 53-61
- DOI
  10.1007/978-1-0716-1495-2_6
- ISBN
  9781071614945, 9781071614952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-21K06558
[Journal Article] タウ免疫療法の現状2021
- Author(s)
  富田泰輔、堀由起子
- Journal Title
  
  Geriatric Medicine（老年医学）
  
  Volume: 59 Pages: 185-189
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Photo-Oxygenation: An Innovative New Therapeutic Approach Against Amyloidoses2021
- Author(s)
  Ikeda Tetsuo、Hori Yukiko、Sohma Youhei、Kanai Motomu、Tomita Taisuke
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1 Pages: 415-422
- DOI
  10.1007/978-3-030-78787-5_52
- ISBN
  9783030787868, 9783030787875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-23K21357
[Journal Article] Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons2021
- Author(s)
  Watanabe Hirotaka、Imaizumi Kent、Cai Tetsuo、Zhou Zhi、Tomita Taisuke、Okano Hideyuki
- Journal Title
  
  eneuro
  
  Volume: 8 Issue: 2 Pages: 0-1
- DOI
  10.1523/eneuro.0500-20.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-19K16927
[Journal Article] Identification of calcium and integrin‐binding protein 1 as a novel regulator of production of amyloid β peptide using CRISPR/Cas9‐based screening system2020
- Author(s)
  Chiu Yung Wen、Hori Yukiko、Ebinuma Ihori、Sato Haruaki、Hara Norikazu、Ikeuchi Takeshi、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 6 Pages: 7661-7674
- DOI
  10.1096/fj.201902966rr
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] EphA4 regulates Aβ production via BACE1 expression in neurons2020
- Author(s)
  Tamura Kensuke、Chiu Yung‐Wen、Shiohara Azusa、Hori Yukiko、Tomita Taisuke
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 12 Pages: 16383-16396
- DOI
  10.1096/fj.202001510r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18K06653
[Journal Article] Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms2020
- Author(s)
  Yumoto Takafumi、Kimura Misaki、Nagatomo Ryota、Sato Tsukika、Utsunomiya Shun、Aoki Natsue、Kitaura Motoji、Takahashi Koji、Takemoto Hiroshi、Watanabe Hirotaka、Okano Hideyuki、Yoshida Fumiaki、Nao Yosuke、Tomita Taisuke
- Journal Title
  
  Molecular Autism
  
  Volume: 11 Issue: 1 Pages: 0-1
- DOI
  10.1186/s13229-020-00373-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21471, KAKENHI-PROJECT-19H01015
[Journal Article] Peptide-based short single β-strand mimics without hydrogen bonding or aggregation2020
- Author(s)
  Zhai Luhan、Otani Yuko、Hori Yukiko、Tomita Taisuke、Ohwada Tomohiko
- Journal Title
  
  Chemical Communications
  
  Volume: 56 Issue: 10 Pages: 1573-1576
- DOI
  10.1039/c9cc08378b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18H02552
[Journal Article] Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures2020
- Author(s)
  Pampuscenko Katryna、Morkuniene Ramune、Krasauskas Lukas、Smirnovas Vytautas、Tomita Taisuke、Borutaite Vilmante
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 58 Issue: 2 Pages: 658-667
- DOI
  10.1007/s12035-020-02150-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Structures of α-synuclein filaments from multiple system atrophy2020
- Author(s)
  Schweighauser Manuel、Shi Yang、Tarutani Airi、Kametani Fuyuki、Murzin Alexey G.、Ghetti Bernardino、Matsubara Tomoyasu、Tomita Taisuke、Ando Takashi、Hasegawa Kazuko、Murayama Shigeo、Yoshida Mari、Hasegawa Masato、Scheres Sjors H. W.、Goedert Michel
- Journal Title
  
  Nature
  
  Volume: 585 Issue: 7825 Pages: 464-469
- DOI
  10.1038/s41586-020-2317-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-20K16482, KAKENHI-PROJECT-16H06277
[Journal Article] CD2-associated protein (CD2AP) overexpression accelerates amyloid precursor protein (APP) transfer from early endosomes to the lysosomal degradation pathway2019
- Author(s)
  Furusawa K, Takasugi T, Chiu YW, Hori Y, Tomita T, Fukuda M, Hisanaga SI
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 294(28) Issue: 28 Pages: 10886-10899
- DOI
  10.1074/jbc.ra118.005385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K06942, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18J01378
[Journal Article] Conformational Dynamics of Transmembrane Domain 3 of Presenilin 1 Is Associated with the Trimming Activity of γ-Secretase2019
- Author(s)
  Cai Tetsuo、Morishima Kanan、Takagi-Niidome Shizuka、Tominaga Aya、Tomita Taisuke
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 39 Issue: 43 Pages: 8600-8610
- DOI
  10.1523/jneurosci.0838-19.2019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18J14653
[Journal Article] Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms2019
- Author(s)
  Takatori Sho、Wang Wenbo、Iguchi Akihiro、Tomita Taisuke
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 1118 Pages: 83-116
- DOI
  10.1007/978-3-030-05542-4_5
- ISBN
  9783030055417, 9783030055424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-17K15446, KAKENHI-PROJECT-19H01015
[Journal Article] Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH2019
- Author(s)
  Cai Tetsuo、Hatano Aki、Kanatsu Kunihiko、Tomita Taisuke
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 167 Issue: 5 Pages: 463-471
- DOI
  10.1093/jb/mvz110
- NAID
  40022226790
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-18J14653
[Journal Article] Photo-oxygenation inhibits tau amyloid formation2019
- Author(s)
  Suzuki T*, Hori Y*, Sawazaki T, Shimizu Y, Nemoto Y, Taniguchi A, Ozawa S, Sohma Y, Kanai M, Tomita T
- Journal Title
  
  Chem. Commun.
  
  Volume: 55(44) Issue: 44 Pages: 6165-6168
- DOI
  10.1039/c9cc01728c
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-19K07001, KAKENHI-PROJECT-19K22484, KAKENHI-PROJECT-19H01015, KAKENHI-PROJECT-19J14873, KAKENHI-PROJECT-19J23179, KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-17H01522, KAKENHI-PROJECT-16H06216
[Journal Article] Nr CAM is a marker for substrate‐selective activation of ADAM 10 in Alzheimer's disease2019
- Author(s)
  Brummer Tobias、Muller Stephan A、Pan‐Montojo Francisco、Yoshida Fumiaki、Fellgiebel Andreas、Tomita Taisuke、Endres Kristina、Lichtenthaler Stefan F
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 11 Issue: 4 Pages: 9695-9695
- DOI
  10.15252/emmm.201809695
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Journal Article] Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide2018
- Author(s)
  Ni Jizhi、Taniguchi Atsuhiko、Ozawa Shuta、Hori Yukiko、Kuninobu Yoichiro、Saito Takashi、Saido Takaomi C.、Tomita Taisuke、Sohma Youhei、Kanai Motomu
- Journal Title
  
  Chem
  
  Volume: 4 Issue: 4 Pages: 807-820
- DOI
  10.1016/j.chempr.2018.02.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19479, KAKENHI-PROJECT-17K19480, KAKENHI-PROJECT-17K13260, KAKENHI-PLANNED-17H06442, KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-16H06216, KAKENHI-PROJECT-17H01522
[Journal Article] Structural Analysis of Target Protein by Substituted Cysteine Accessibility Method2018
- Author(s)
  Cai Tetsuo、Tomita Taisuke
- Journal Title
  
  BIO-PROTOCOL
  
  Volume: 8 Issue: 17 Pages: 8-8
- DOI
  10.21769/bioprotoc.2470
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-18J14653
[Journal Article] AP180 N-Terminal Homology (ANTH) and Epsin N-Terminal Homology (ENTH) Domains: Physiological Functions and Involvement in Disease2018
- Author(s)
  Takatori Sho、Tomita Taisuke
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: in press Pages: 1-22
- DOI
  10.1007/5584_2018_218
- ISBN
  9783030143381, 9783030143398
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-17K15446
[Journal Article] Specific mutations in presenilin 1 cause conformational changes in γ-secretase to modulate amyloid β trimming2018
- Author(s)
  Imai So、Cai Tetsuo、Yoshida Chika、Tomita Taisuke、Futai Eugene
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 165 Issue: 1 Pages: 37-46
- DOI
  10.1093/jb/mvy081
- NAID
  40021789427
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-16K07290, KAKENHI-PROJECT-19K06558
[Journal Article] Physiological and pathological functions of LRRK2: implications from substrate proteins2018
- Author(s)
  Araki Miho、Ito Genta、Tomita Taisuke
- Journal Title
  
  Neuronal Signaling
  
  Volume: 2 Issue: 4
- DOI
  10.1042/ns20180005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08265, KAKENHI-PROJECT-15H02492
[Journal Article] Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production.2018
- Author(s)
  Kanatsu K, Hori Y, Ebinuma I, Chiu YW, Tomita T
- Journal Title
  
  J. Neurochem.
  
  Volume: 147(1) Issue: 1 Pages: 110-123
- DOI
  10.1111/jnc.14477
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06653, KAKENHI-PROJECT-15H02492
[Journal Article] Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer’s disease model mice2018
- Author(s)
  Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T
- Journal Title
  
  EMBO Molecular Medicine
  
  Volume: 10 Issue: 3
- DOI
  10.15252/emmm.201708184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15446, KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-15H04800, KAKENHI-PROJECT-16K18871
[Journal Article] High performance plasma amyloid-β biomarkers for Alzheimer’s disease2018
- Author(s)
  Nakamura Akinori、Kaneko Naoki、Villemagne Victor L.、Kato Takashi、Doecke James、Dor? Vincent、Fowler Chris、Li Qiao-Xin、Martins Ralph、Rowe Christopher、Tomita Taisuke、Matsuzaki Katsumi、Ishii Kenji、Ishii Kazunari、Arahata Yutaka、Iwamoto Shinichi、Ito Kengo、Tanaka Koichi、Masters Colin L.、Yanagisawa Katsuhiko
- Journal Title
  
  Nature
  
  Volume: 554 Issue: 7691 Pages: 249-254
- DOI
  10.1038/nature25456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking.2017
- Author(s)
  Ito K, Tatebe, Suzuki K, Hirayama T, Hayakawa M, Kubo H, Tomita T, Makino M
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 798 Pages: 16-25
- DOI
  10.1016/j.ejphar.2017.02.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-14J07587
[Journal Article] Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 12017
- Author(s)
  Cai Tetsuo、Yonaga Masahiro、Tomita Taisuke
- Journal Title
  
  The Journal of Neuroscience
  
  Volume: 37 Issue: 50 Pages: 12272-12280
- DOI
  10.1523/jneurosci.1628-17.2017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Probing the structure and function relationships of presenilin by substituted-cysteine accessibility method.2017
- Author(s)
  Tomita T
- Journal Title
  
  Methods in Enzymology
  
  Volume: 584 Pages: 185-205
- DOI
  10.1016/bs.mie.2016.10.033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif.2017
- Author(s)
  Sakurai S, Tomita T, Shimizu T, Ohto U
- Journal Title
  
  Acta Crystallographica Section F
  
  Volume: 73 Issue: 3 Pages: 130-137
- DOI
  10.1107/s2053230x17001911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K14471
[Journal Article] Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag2017
- Author(s)
  Genta Ito, Taisuke Tomita
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: － Issue: 130
- DOI
  10.3791/56688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08265, KAKENHI-PROJECT-15H02492
[Journal Article] Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease.2017
- Author(s)
  Kanatsu K and Tomita T
- Journal Title
  
  Front Biosci (Landmark Ed)
  
  Volume: 22 Pages: 180-192
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer’s Disease2017
- Author(s)
  Liu Collin Y.、Ohki Yu、Tomita Taisuke、Osawa Satoko、Reed Bruce R.、Jagust William、Van Berlo Victoria、Jin Lee-Way、Chui Helena C.、Coppola Giovanni、Ringman John M.
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 58 Issue: 4 Pages: 1035-1041
- DOI
  10.3233/jad-161203
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.2017
- Author(s)
  Tomita T
- Journal Title
  
  Adv Biol Regul
  
  Volume: in press Pages: 33-38
- DOI
  10.1016/j.jbior.2017.01.001
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease2017
- Author(s)
  Kikuchi Kazunori、Kidana Kiwami、Tatebe Takuya、Tomita Taisuke
- Journal Title
  
  Journal of Cellular Biochemistry
  
  Volume: 118 Issue: 12 Pages: 4183-4190
- DOI
  10.1002/jcb.26129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease2016
- Author(s)
  Kanatsu K and Tomita T
- Journal Title
  
  Front Biosci (Landmark Ed)
  
  Volume: 1
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111705
[Journal Article] BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.2016
- Author(s)
  Miyagawa T, Ebinuma I, Morohashi Y, Hori Y, Chang MY, Hattori H, Maehara T, Yokoshima S, Fukuyama T, Tsuji S, Iwatsubo T, Prendergast GC, Tomita T
- Journal Title
  
  Hum Mol Genet
  
  Volume: 25 Pages: 2948-2958
- DOI
  10.1093/hmg/ddw146
- NAID
  120006347252
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-14J11303
[Journal Article] Membrane trafficking and proteolytic activity of γ-secretase in Alzheimer disease.2016
- Author(s)
  Kanatsu K and Tomita T
- Journal Title
  
  Biol Chem
  
  Volume: 397 Issue: 9 Pages: 827-835
- DOI
  10.1515/hsz-2016-0146
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons2016
- Author(s)
  Hayashi Y, Nishimune H, Hozumi K, Saga Y, Harada A, Yuzaki M, Iwatsubo T, Kopan R, Tomita T.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 23969-23969
- DOI
  10.1038/srep23969
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23110009, KAKENHI-PROJECT-15H05772, KAKENHI-PROJECT-14J07589, KAKENHI-PROJECT-26830017, KAKENHI-PROJECT-15H02492
[Journal Article] Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.2016
- Author(s)
  Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T
- Journal Title
  
  Hum Mol Genet
  
  Volume: 25 Issue: 18 Pages: 3988-3997
- DOI
  10.1093/hmg/ddw239
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] A systematic cell-free methodology to produce mammalian membrane proteins for crystallography.2016
- Author(s)
  Shinoda T, Shinya N, Ito K, Ishizuka-Katsura Y, Ohsawa N, Terada T, Hirata K, Kawano Y, Yamamoto M, Tomita T, Ishibashi Y, Hirabayashi Y, Tomomi Kimura-Someya T, Shirouzu M, Yokoyama S
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 30442-30442
- DOI
  10.1038/srep30442
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02492, KAKENHI-PROJECT-25840028
[Journal Article] Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities2016
- Author(s)
  Eugene Futai, Satoko Osawa, Tetsuo Cai, Tomoya Fujisawa, Shoichi Ishiura and Taisuke Tomita
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Issue: 1 Pages: 435-436
- DOI
  10.1074/jbc.m114.629287
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102504, KAKENHI-PUBLICLY-26111705, KAKENHI-PROJECT-15H02492
[Journal Article] Rescue of hypovitaminosis A induces non-amyloidogenic Amyloid Precursor Protein (APP) Processing.2016
- Author(s)
  Reinhardt S, Grimm M, Stahlmann C, Hartmann T, Shudo K, Tomita T, Endres K
- Journal Title
  
  Curr Alzheimer Res
  
  Volume: 13 Pages: 1277-1289
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo2016
- Author(s)
  Kanatsu K, Hori Y, Takatori S, Watanabe T, Iwatsubo T, Tomita T
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 1
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111705
[Journal Article] Conformational changes in transmembrane domain 4 of presenilin 1 are associated with altered Aβ42 production2016
- Author(s)
  Tominaga A, Cai T, Takagi-Niidome S, Iwatsubo T, Tomita T
- Journal Title
  
  J Neurosci
  
  Volume: 36 Issue: 4 Pages: 1362-1372
- DOI
  10.1523/jneurosci.5090-14.2016
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111705, KAKENHI-PROJECT-15H02492
[Journal Article] Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.2016
- Author(s)
  Ueda N, Tomita T, Yanagisawa K, Kimura N
- Journal Title
  
  J Neurochem
  
  Volume: 137 Issue: 4 Pages: 647-658
- DOI
  10.1111/jnc.13586
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02492
[Journal Article] Cooperative roles of hydrophilic loop 1 and the C terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.2015
- Author(s)
  Shizuka Takagi-Niidome, Tomoki Sasaki, Satoko Osawa, Takeshi Sato, Kanan Morishima, Tetsuo Cai, Takeshi Iwatsubo, and Taisuke Tomita
- Journal Title
  
  J. Neurosci.
  
  Volume: 35 Issue: 6 Pages: 2646-2656
- DOI
  10.1523/jneurosci.3164-14.2015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24687013, KAKENHI-PROJECT-26650015, KAKENHI-PROJECT-15H02492
[Journal Article] Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene.2014
- Author(s)
  Qina, T., N. Sanjo, M. Hizume, M. Higuma, M. Tomita, R. Atarashi, K. Satoh, I. Nozaki, T. Hamaguchi, Y. Nakamura, A. Kobayashi, T. Kitamoto, S. Murayama, H. Murai, M. Yamada and H. Mizusawa
- Journal Title
  
  BMJ Open
  
  Volume: 4 Issue: 5 Pages: e004968-e004968
- DOI
  10.1136/bmjopen-2014-004968
- NAID
  120006986552
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23300127, KAKENHI-PROJECT-24591268, KAKENHI-PROJECT-25257506, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-26305030, KAKENHI-PROJECT-26670435
[Journal Article] Biophysical analysis of reciprocal allosteric interactions between gamma-secretase inhibitor and initial substrate binding sites give insight into human presenilin-1 complex function.2014
- Author(s)
  Li Y, Hsueh-Jeng Lu S, Tsai CJ, Bohm C, Qamar S, Dodd RB, McDonald B, Meadows W, Jeoh A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Schmitt-Ulms, S, Fraser P, St. George-Hyslop P
- Journal Title
  
  Structure
  
  Volume: 22 Issue: 1 Pages: 125-135
- DOI
  10.1016/j.str.2013.09.018
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111511
[Journal Article] Decreased CALM expression reduces Aβ42 production ratio through clathrin-mediated endocytosis of Y-secretase.2014
- Author(s)
  金津邦彦
- Journal Title
  
  Nature Communications
  
  Volume: 5 Issue: 1 Pages: 3386-3386
- DOI
  10.1038/ncomms4386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J10187, KAKENHI-PUBLICLY-24111511, KAKENHI-PROJECT-24570159
[Journal Article] Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity.2014
- Author(s)
  Nobumasa Takasugi; Tomoki Sasaki; Mitsuru Shinohara; Takeshi Iwatsubo; Taisuke Tomita
- Journal Title
  
  Biochemical and biophysical research communications.
  
  Volume: 457 Issue: 2 Pages: 194-199
- DOI
  10.1016/j.bbrc.2014.12.087
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430059
[Journal Article] Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment.2014
- Author(s)
  Okada K, Nakao T, Sanematsu H, Murayama K, Honda S, Tomita M, Togao O, Yoshiura T, Kanba S.
- Journal Title
  
  Psychiatry Clin Neurosci.
  
  Volume: 印刷中 Issue: 7 Pages: 411-421
- DOI
  10.1111/pcn.12269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-24591719, KAKENHI-PROJECT-25461732, KAKENHI-PROJECT-25861017
[Journal Article] Attenuated aggregation and neurotoxicity of amyloid-beta peptide by catalytic photo-oxidation.2014
- Author(s)
  Taniguchi A, Sasaki D, Shiohara A, Iwatsubo T, Tomita T, Sohma Y, Kanai M
- Journal Title
  
  Angew Chem Int Ed Engl
  
  Volume: 53 Issue: 5 Pages: 1382-1385
- DOI
  10.1002/anie.201308001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111511, KAKENHI-PUBLICLY-26105709
[Journal Article] Differentiation of CD11c+CX3CR1+ cells in the small intestine requires Notch signaling.2014
- Author(s)
  Ishifune C, Maruyama S, Sasaki Y, Yagita H, Hozumi K, Tomita T, Kishihara K, Yasutomo K
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 111 Issue: 16 Pages: 5986-5991
- DOI
  10.1073/pnas.1401671111
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111511
[Journal Article] Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation2014
- Author(s)
  Ohki Y, Shimada N, Osawa S, Higo T, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T.
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 9:7 Issue: 1 Pages: 7-7
- DOI
  10.1186/1750-1326-9-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04981, KAKENHI-PUBLICLY-24111511
[Journal Article] Lack of genetic association between TREM2 and late-onset Alzheimer’s disease in a Japanese population2014
- Author(s)
  Akinori Miyashitaa, Yanan Wen　他
- Journal Title
  
  J Alzheimer's Dis.
  
  Volume: 印刷中 Issue: 4 Pages: 1301-1308
- DOI
  10.3233/jad-140225
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-221S0003, KAKENHI-PROJECT-23591231, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-24390179, KAKENHI-PROJECT-24500431, KAKENHI-PROJECT-24700371, KAKENHI-PROJECT-25670415, KAKENHI-PROJECT-26460907, KAKENHI-PROJECT-26461264
[Journal Article] Structural biology of presenilins and signal peptide peptidases.2013
- Author(s)
  Tomita T, Iwatsubo T
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Pages: 14673-14680
- Data Source
  KAKENHI-PUBLICLY-24111511
[Journal Article] FTY720/Fingolimod, a sphingosine analogue, reduces amyloid-beta production in neurons.2013
- Author(s)
  Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T*, Iwatsubo T
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111511
[Journal Article] Effect of helical conformation and side-chain structure on gamma-secretase inhibition by beta-peptide foldamers: Insight into substrate recognition.2013
- Author(s)
  Imamura Y, Umezawa N, Osawa S, Shimada N, Higo T, Yokoshima S, Fukuyama T, Iwatsubo T, Kato N, Tomita T*, Higuchi T
- Journal Title
  
  J Med Chem
  
  Volume: 56 Pages: 1443-1454
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111511
[Journal Article] FTY720/Fingolimod, a sphingosine analogue, reduces amyloid-〓 production in neurons2013
- Author(s)
  Takasugi N, Sasaki T, Ebinuma I, Osawa S, Isshiki H, Takeo K, Tomita T, Iwatsubo T
- Journal Title
  
  PloS ONE
  
  Volume: 8(5) Issue: 5 Pages: e64050-e64050
- DOI
  10.1371/journal.pone.0064050
- Data Source
  KAKENHI-PROJECT-24659028
[Journal Article] Structural biology of presenilins and signal peptide peptidases.2013
- Author(s)
  Tomita T
- Journal Title
  
  J Biol Chem
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659028
[Journal Article] Protein trafficking and maturation regulates intramembrane proteolysis.2013
- Author(s)
  Morohashi Y, Tomita T
- Journal Title
  
  BBA-Biomembranes
  
  Volume: 1828 Issue: 12 Pages: 2855-2861
- DOI
  10.1016/j.bbamem.2013.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111511, KAKENHI-PROJECT-24590076
[Journal Article] Structural biology of presenilins and signal peptide peptidases.2013
- Author(s)
  Tomita T
- Journal Title
  
  J Biol Chem
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24111511
[Journal Article] Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.2013
- Author(s)
  Hoshi, M. et al.
- Journal Title
  
  BMC Biochem.
  
  Volume: 14 Issue: 1 Pages: 16-16
- DOI
  10.1186/1471-2091-14-16
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23248058, KAKENHI-PUBLICLY-24111511, KAKENHI-PROJECT-25292068, KAKENHI-PROJECT-25560046
[Journal Article] Inhibition of g-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 12013
- Author(s)
  Shizuka Takagi-Niidome
- Journal Title
  
  Biochemistry
  
  Volume: 52 Issue: 1 Pages: 61-69
- DOI
  10.1021/bi301252r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J00097, KAKENHI-PROJECT-24659028, KAKENHI-PUBLICLY-24111511
[Journal Article] Neutralizationof theγ-secretase activity bymonoclonal antibody againstextracellular domain of nicastrin2012
- Author(s)
  Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
- Journal Title
  
  Oncogene
  
  Volume: 31 Issue: 6 Pages: 787-79
- DOI
  10.1038/onc.2011.265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001, KAKENHI-PROJECT-20221010, KAKENHI-PUBLICLY-22121513, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-23791068, KAKENHI-ORGANIZER-24111001
[Journal Article] Activity-dependent proteolytic cleavage of neuroligin-12012
- Author(s)
  Suzuki K, Hayashi Y, Nakahara S, Kumazaki H, Prox J, Horiuchi K, Zeng M, Tanimura S, Nishiyama Y, Osawa S, Sehara-Fujisawa A, Saftig P, Yokoshima S, Fukuyama T, Matsuki N, Koyama R, Tomita T, Iwatsubo T.
- Journal Title
  
  Neuron
  
  Volume: 76(2) Issue: 2 Pages: 410-422
- DOI
  10.1016/j.neuron.2012.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J10924, KAKENHI-PROJECT-12J10970, KAKENHI-PLANNED-22110003, KAKENHI-PROJECT-22370076, KAKENHI-PROJECT-22390012, KAKENHI-PROJECT-24650171, KAKENHI-PROJECT-24657154, KAKENHI-PROJECT-24659028, KAKENHI-PLANNED-22122007, KAKENHI-PUBLICLY-24111511
[Journal Article] Contribution of〓-secretase cofactors to the formation of catalytic pore of presenilin 12012
- Author(s)
  Takeo K, Watanabe N, Tomita T, Iwatsubo T
- Journal Title
  
  J Biol Chem
  
  Volume: 287(31) Issue: 31 Pages: 25834-25843
- DOI
  10.1074/jbc.m111.336347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659028, KAKENHI-PUBLICLY-24111511
[Journal Article] Three dimensional structure of signal peptide peptidase2011
- Author(s)
  Miyashita H, Maruyama Y, Isshiki H, Osawa S, Ogura T, Mio K, Sato C, Tomita T, Iwatsubo T
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 26188-26197
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] BACE1 activity ismodulated by cell-associatedsphingosine-1-phosphate in neurons2011
- Author(s)
  Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VMY, Trojanowski JQ, Tomita T, Iwatsubo T
- Journal Title
  
  J Neurosci
  
  Volume: 31 Pages: 6850-6857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Comparison of Presenilin 1 and Presenilin 2 γ-Secretase Activities Using a Yeast Reconstitution System2011
- Author(s)
  Yonemura Y, Futai E, Yagishita S, Suo S, Tomita T, Iwatsubo T, Ishiura S
- Journal Title
  
  J Biol Chem
  
  Volume: 52 Pages: 44569-44575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 12011
- Author(s)
  Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T
- Journal Title
  
  The EMBO Journal
  
  Volume: 30巻 Issue: 23 Pages: 4815-4824
- DOI
  10.1038/emboj.2011.372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J10622, KAKENHI-PROJECT-11J04981, KAKENHI-PROJECT-19679001, KAKENHI-PLANNED-22110003
[Journal Article] Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's.2011
- Author(s)
  Taisuke Tomita
- Journal Title
  
  Alzheimer's Research & Therapy
  
  Volume: 3 Pages: 7-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Iwatsubo T : BACE1 activity is modulated by cell-associated sphingosine-1-phosphate in neurons2011
- Author(s)
  Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VMY, Trojanowski JQ, Tomita T, Iwatsubo T
- Journal Title
  
  J Neurosci
  
  Volume: 31 Pages: 6850-6857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] γ-セクレターゼの構造・機能解析-プロテオミクス解析による創薬標的分子の同定-2010
- Author(s)
  富田泰輔
- Journal Title
  
  実験医学増刊創薬・タンパク質研究のためのプロテオミクス解析
  
  Pages: 197-202
- Data Source
  KAKENHI-PUBLICLY-21025004
[Journal Article] γセクレターゼ阻害/調節薬の作用の分子機構2010
- Author(s)
  富田泰輔
- Journal Title
  
  Psychiatry Today
  
  Volume: 27 Pages: 11-11
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] γセクレターゼモジュレーター:最新情報2010
- Author(s)
  富田泰輔
- Journal Title
  
  Dementia Japan
  
  Volume: 24 Pages: 136-145
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Functionalanalysis of the transmembranedomains of presenilin 1 : PARTICIPATION OFTRANSMEMBRANE DOMAINS 2AND 6 IN THE FORMATION OFINITIAL SUBSTRATE-BINDINGSITE OFγ-SECRETASE2010
- Author(s)
  Watanabe N, Takagi S, Tominaga A, Tomita T, Iwatsubo T
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 19738-19746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Participation oftransmembrane domain 1 ofpresenilin 1 in the catalytic porestructure of theγ-secretase2010
- Author(s)
  Takagi S, Tominaga A, Tomita T, Iwatsubo T
- Journal Title
  
  J Neurosci
  
  Volume: 30 Pages: 15943-15050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] 疾患メカニズム:アミロイド前駆体蛋白/アミロイドβ蛋白2010
- Author(s)
  富田泰輔
- Journal Title
  
  Psychiatry Tbday
  
  Volume: 25 Pages: 10-12
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Secretase inhibitors andmodulators for Alzheimer's diseasetreatment2009
- Author(s)
  Tomita T
- Journal Title
  
  Expert RevNeurotherapeutics
  
  Volume: 5 Pages: 661-679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Secretase inhibitors and modulators for Alzheimer's disease treatment2009
- Author(s)
  Tomita T
- Journal Title
  
  Expert Rev Neurotherapeutics 5
  
  Pages: 661-679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023007
[Journal Article] Inhibition of gamma-secretaseactivity by helical beta-peptidefoldamers2009
- Author(s)
  Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T
- Journal Title
  
  J Am Chem Soc
  
  Volume: 131 Pages: 7353-7359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Single chain variable fragmentagainst Nicastrin inhibits theγ-secretase activity2009
- Author(s)
  Hayashi I, Takatori S, Urano Y Iwanari H, Isoo N, Osawa S, FukudaMA, Kodama T, Hamakubo T, Li T, Wong PC, Tomita T, Iwatsubo T
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 27838-27847
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Inhibition of gamma-secretase activity by helical beta-peptide foldamers2009
- Author(s)
  Imamura Y, Watanabe N, Umezawa N, Iwatsubo T, Kato N, Tomita T, Higuchi T
- Journal Title
  
  J Am Chem Soc 131
  
  Pages: 7353-7359
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Secretase inhibitors and modulators for Alzheimer's disease treatment2009
- Author(s)
  Tomita T
- Journal Title
  
  Expert Rev Neurotherapeutics 5
  
  Pages: 661-679
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] S-palmitoylation of gamma-secretase subunits nicastrin and APH-12009
- Author(s)
  Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G
- Journal Title
  
  Journal of Biological Chemistry 284
  
  Pages: 1373-1384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044009
[Journal Article] Secretase inhibitors and modulators for Alzheimer's disease treatment2009
- Author(s)
  Tomita T
- Journal Title
  
  Expert Revews in Neurotherapeutics (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023007
[Journal Article] Secretase inhibitors and modulators for Alzheimer's disease treatment2009
- Author(s)
  Tomita T
- Journal Title
  
  Expert Rev Neurotherapeutics 5
  
  Pages: 661-679
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21025004
[Journal Article] Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity2009
- Author(s)
  Tomita T
- Journal Title
  
  臨床神経学 49
  
  Pages: 845-847
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Secretase inhibitors and modulators for Alzheimer's disease treatment.2009
- Author(s)
  Tomita T
- Journal Title
  
  Expert Rev Neurotherapeutics 5
  
  Pages: 661-679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Biology and pathobiology of the intramembrane proteolysis by gamma-secretase2009
- Author(s)
  Tomita T
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 1747-1753
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] The C-terminal PAL motif and transmembrane domain 9 of Presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase2008
- Author(s)
  Sato C, Takagi S, Tomita T, Iwatsubo T
- Journal Title
  
  Journal of Neuroscience 28
  
  Pages: 6264-6271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023007
[Journal Article] Synthesis and biological activity of Nsubstituted spiro[benzoxazepine-piperidine] Abeta-peptide production inhibitors2008
- Author(s)
  Laras Y, Pietrancosta N, Tomita T, Iwatsubo T, Kraus JL
- Journal Title
  
  Journal of Enzyme Inhibition and Medicinal Chemistry 23
  
  Pages: 996-1001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023007
[Journal Article] At the Frontline of Alzheimer's disease treatment:γ-secretase inhibitor/modulator mechanism.2008
- Author(s)
  Tomita T
- Journal Title
  
  Naunyn-Schmiedeberg Arch pharmacol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044009
[Journal Article] At the Frontline of Alzheimer's disease treatment: γ-secretase inhibitor/modulator mechanism.2008
- Author(s)
  Tomita T
- Journal Title
  
  Naunyn-Schmiedeberg Arch Pharmacol (掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18023010
[Journal Article] Peptides inhibiting specific cleaving activities of presenilins2008
- Author(s)
  Tomita T
- Journal Title
  
  Expert Opinion in Patents 18
  
  Pages: 1097-1100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023007
[Journal Article] At the Frontline of Alzheimer's disease treatment : γ-secretase inhibitor/modulator mechanism.2008
- Author(s)
  Tomita T
- Journal Title
  
  Naunyn-Schmiedeberg Arch Pharmacol (In press)
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] The C-terminal PAL motif and transmembrane domain 9 of Presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase2008
- Author(s)
  Sato C, Takagi S, Tomita T, Iwatsubo T
- Journal Title
  
  J Neurosci 28
  
  Pages: 6264-6271
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] At the Frontline of Alzheimer's disease treatment: γ-secretase inhibitor/modulator mechanism.2008
- Author(s)
  Tomita T
- Journal Title
  
  Naunyn-Schmiedeberg Arch Pharmacol in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Peptides inhibiting specific cleaving activities of presenilins2008
- Author(s)
  Tomita T
- Journal Title
  
  Expert Opinion in Patents 18
  
  Pages: 1097-1100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044009
[Journal Article] Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP(3) receptor channel gating2008
- Author(s)
  Cheung KH, Shineman D, Muller M, Cardenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK
- Journal Title
  
  Neuron 58
  
  Pages: 871-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023007
[Journal Article] Both Notchl and Notch2 contribute to the regulation of melanocyte stem cells2008
- Author(s)
  Kumano K, Masuda S, Sata M, Saito T, Lee SY, Yanagimoto-Sakata M, Tomita T, Iwatsubo T, Natsugari H, Kurokawa M, Ogawa S, Chiba S
- Journal Title
  
  Pigment Cell Research 21
  
  Pages: 70-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20023007
[Journal Article] The C-terminal PAL motif andtransmembrane domain 9 ofPresenilin 1 are involved in theformation of the catalytic pore of thegamma-secretase2008
- Author(s)
  Sato C, Takagi S, Tomita T, IwatsuboT
- Journal Title
  
  J Neurosci
  
  Volume: 28 Pages: 6264-6271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] At the Frontline of Alzheimer's disease treatment: γ-secretase inhibitor/modulator mechanism.2007
- Author(s)
  Tomita T
- Journal Title
  
  Naunyn-Schmiedeberg Arch Pharmacol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic y-secretase inhibitors.2007
- Author(s)
  Fuwa H, Konno Y, Takahashi Y, Sasaki M, Yokoshima S, Kan T, Fukuyama T, Natsugari H, Tomita T, Iwatsubo T
- Journal Title
  
  ACS Chem Biol 2
  
  Pages: 408-418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Aβ42 overproduction associated with structural changes in the catalytic pore of y-secretase : common effects of Pen-2 amino-terminal elongation and fenofibrate.2007
- Author(s)
  Isoo N, Sato C, Miyashita H, Shinohara M, Takasugi N, Morohashi Y, Tsuji S, Tomita T, Iwatsubo T
- Journal Title
  
  J Biol Chem 282
  
  Pages: 12388-12396
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors2007
- Author(s)
  Fuwa H, Konno Y, Takahashi Y, Sasaki M, Yokoshima S, Kan T, Fukuyama T, Natsugari H, Tomita T, Iwatsubo T
- Journal Title
  
  ACS Chem Biol 2
  
  Pages: 408-418
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Divergent synthesis ofmultifunctional molecular probes toelucidate the enzyme specificity ofdipeptidic gamma-secretase inhibitors2007
- Author(s)
  Fuwa H, Konno Y, Takahashi Y, Sasaki M, Yokoshima S, Kan T, Fukuyama T, Natsugari H, Tomita T, Iwatsubo T
- Journal Title
  
  ACS Chem Biol
  
  Volume: 2 Pages: 408-418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001
[Journal Article] Convenient synthesis of photoaffinity probes and evaluation of their cross-linking abilities2007
- Author(s)
  Kan T, Kita Y, Morohashi Y, Tominari Y, Hosoda S, Tomita T, Natsugari H, Iwatsubo T, Fukuyama T
- Journal Title
  
  Org lett 9
  
  Pages: 2055-2058
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Concise and short synthesis of functionalized 5,6-Dihydropyridin-2-ones by means of palladium(0)-catalyzed cross-coupling of ketene aminal phosphates.2006
- Author(s)
  Fuwa H, Kaneko A, Sugimoto Y, Tomita T, Iwatsubo T, Sasaki M
- Journal Title
  
  Heterocycles 70
  
  Pages: 101-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] γ-Secretase as a therapeutic target for treatment of Alzheimer's disease.2006
- Author(s)
  Tomita T, Iwatsubo T
- Journal Title
  
  Current Pharmaceutical Design 12
  
  Pages: 661-670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Presenilin-dependent intramembrane cleavage of ephrin-B1.2006
- Author(s)
  Tomita T
- Journal Title
  
  Molecular Neurodegeneration 1
  
  Pages: 2-2
- Data Source
  KAKENHI-PROJECT-18060012
[Journal Article] γ-Secretase as a therapeutic target for treatment of Alzheimer's disease.2006
- Author(s)
  Tomita T
- Journal Title
  
  Current Pharmaceutical Design 17
  
  Pages: 321-325
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] AMPAR removal underlies An-induced synaptic depression and dendritic spine loss.2006
- Author(s)
  Hsieh H, Boehm J, Sato C, Iwatsubo T, Tomita T, Sisodia S, Malinow R
- Journal Title
  
  Neuron 52
  
  Pages: 831-843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis.2006
- Author(s)
  Ozaki T, Li Y, Kikuchi H, Tomita T, Iwatsubo T, Nakagawara A
- Journal Title
  
  Biochem Biophys Res Comm 351
  
  Pages: 57-63
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Notchl signaling influences V2 interneuron and motor neuron development in the spinal cord.2006
- Author(s)
  Yang X, Tomita T, Wines-Samuelson M, Beglopoulos V, Tansey MG, Kopan R, Shen J
- Journal Title
  
  Dev Neurosci 28
  
  Pages: 102-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Naphthyl and coumarinyl biarylpiperazine derivatives as highly potent human β-secretase inhibitors. Design, synthesis, enzymatic BACE-1 and cell assays.2006
- Author(s)
  Garino C, Tomita T, Pietrancosta N, Laras Y, Rosas R, Herbette G, Maigret B, Quelever G, Iwatsubo T, Kraus J.-L
- Journal Title
  
  J Med Chem 49
  
  Pages: 4275-4285
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] A faster migrating variant masquerades as NICD when performing in vitro y-secretase assays with bacterially expressed Notch substrates.2006
- Author(s)
  Keller II PC, Tomita T, Hayashi I, Chandu D, Webber JI , Cistola DP, Kopan R
- Journal Title
  
  Biochemistry 45
  
  Pages: 5351-5358
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Novel γ-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates.2006
- Author(s)
  Takahashi Y, Fuwa H, Kaneko A, Sasaki M, Yokoshima S, Koizumi H, Takebe T, Kan T, Iwatsubo T, Tomita T, Natsugari H, Fukuyama T
- Journal Title
  
  Bioorg Med Chem Lett 16
  
  Pages: 3813-3816
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Presenilin-dependent intramembrane cleavage of ephrin-B12006
- Author(s)
  Tomita T
- Journal Title
  
  Mol Neurodegener 1
  
  Pages: 2-2
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors.2006
- Author(s)
  Fuwa H, Hiromoto K, Takahashi Y, Yokoshima S, Kan T, Fukuyama T, Iwatsubo T, Tomita T, Natsugari H
- Journal Title
  
  Bioorg Med Chem Lett 16
  
  Pages: 4184-4189
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Three-dimensional structure of the y-secretase complex.2006
- Author(s)
  Ogura T, Mio K, Hayashi I, Miyashita H, Fukuda R, Kopan R, Kodama T, Hamakubo T, Iwatsubo T, Tomita T, Sato C
- Journal Title
  
  Biochem Biophys Res Comm 343
  
  Pages: 525-534
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Presenilin-dependent intramembrane cleavage of ephrin-B1.2006
- Author(s)
  Tomita T, Tanaka S, Morohashi Y, Iwatsubo T
- Journal Title
  
  Molecular Neurodegeneration 1
  
  Pages: 2-2
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Structure of the catalytic pore of y-secretase probed by the accessibility of substituted cysteines.2006
- Author(s)
  Sato C, Morohashi Y, Tomita T, Iwatsubo T
- Journal Title
  
  J Neurosci 26
  
  Pages: 12081-12088
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] C-terminal fragment of Presenilin is the molecular target of a dipeptidic γ-secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester).2006
- Author(s)
  Morohashi Y, Kan T, Tominari Y, Fuwa H, Okamura Y, Watanabe N, Sato C, Natsugari H, Fukuyama T, Iwatsubo T, Tomita T
- Journal Title
  
  J Biol Chem 281
  
  Pages: 14670-14676
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] γ-secretase as a therapeutic target for treatment of Alzheimer's disease.2006
- Author(s)
  Tomita T
- Journal Title
  
  Current Phamaceutical Design 17
  
  Pages: 321-325
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Iwatsubo Aph-1 contributes to the stabilization and trafficking of the y-secretase complex through mechanisms involving inter-and intramolecular interactions.2005
- Author(s)
  Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T
- Journal Title
  
  J Biol Chem 280
  
  Pages: 12967-12975
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Association of active γ-secretase complex with lipid rafts.2005
- Author(s)
  Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo Kodama T
- Journal Title
  
  J Lipid Res 46
  
  Pages: 904-912
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Pen-2 is incorporated into the y-secretase complex through binding to transmembrane domain 4 of presenilin 1.2005
- Author(s)
  Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T
- Journal Title
  
  J Biol Chem 280
  
  Pages: 41967-41975
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.2005
- Author(s)
  Takeda T, Asahi M, Yamaguchi O, Hikoso S, Nakayama H, Kusakari Y, Kawai M, Hongo K, Higuchi Y, Kashiwase K, Watanabe T, Taniike M, Nakai A, Nishida K, Kurihara S, Donoviel DB, Bernstein A, Tomita T, Iwatsubo T, Hori M, Otsu K
- Journal Title
  
  FASEB J. 19
  
  Pages: 2069-2071
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Journal Article] At the Frontline of Alzheimer's disease treatment : γ-secretase inhibitor/modulator mechanism.
- Author(s)
  Tomita T
- Journal Title
  
  Naunyn-Schmiedeberg Arch Pharmacol (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Patent] ADAMTS4のAPP切断活性制御物質のスクリーニング方法2019
- Inventor(s)
  金子直樹、富田泰輔、吉澤遥太、松崎将也、横山雅シャラ
- Industrial Property Rights Holder
  金子直樹、富田泰輔、吉澤遥太、松崎将也、横山雅シャラ
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-19H01015
[Patent] 自閉症発症機構に関連する接着分子2019
- Inventor(s)
  富田泰輔、伊藤弦太、高鳥翔、長友亮太、吉田文明
- Industrial Property Rights Holder
  富田泰輔、伊藤弦太、高鳥翔、長友亮太、吉田文明
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-15H02492
[Patent] 情報処理装置、トレーニングシステム、情報処理方法および情報処理プログラム2018
- Inventor(s)
  富田泰輔、他
- Industrial Property Rights Holder
  富田泰輔、他
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-15H02492
[Patent] GPR120シグナル制御によるアルツハイマー病治療法2017
- Inventor(s)
  富田泰輔、菊池一徳、建部卓也、木棚究
- Industrial Property Rights Holder
  富田泰輔、菊池一徳、建部卓也、木棚究
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-15H02492
[Patent] γセクレターゼ活性調節因子2009
- Inventor(s)
  富田泰輔
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2009-277604
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PUBLICLY-21025004
[Patent] γセクレターゼ活性調節因子2009
- Inventor(s)
  富田泰輔
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2009-277604
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-19679001
[Patent] γセクレターゼの活性の阻害によるアルツハイマー病の治療薬探索2009
- Inventor(s)
  富田泰輔, 他8名
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2009-02-03
- Overseas
- Data Source
  KAKENHI-PROJECT-19044009
[Patent] γセクレターゼ活性調節因子2009
- Inventor(s)
  富田泰輔ら
- Industrial Property Rights Holder
  東京大学
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-19679001
[Patent] アルツハイマー病および癌の治療薬2009
- Inventor(s)
  富田泰輔
- Industrial Property Rights Holder
  東京大学
- Acquisition Date
  2009-04-25
- Data Source
  KAKENHI-PROJECT-19679001
[Patent] γセクレターゼ活性調節因子2009
- Inventor(s)
  富田泰輔
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2009-277604
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-20023007
[Patent] γセクレターゼ活性調節因子2009
- Inventor(s)
  富田泰輔, ら
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2009-277604
- Filing Date
  2009-12-07
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Catalytic photo-oxygenation of pathological aggregated tau in vivo.2023
- Author(s)
  富田泰輔
- Organizer
  The 19th Conference of Peace through Mind/Brain Science.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の分子・細胞病態解明2023
- Author(s)
  富田泰輔
- Organizer
  令和4年度山梨大学ライフサイエンスコース冬季リトリート
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の分子細胞病態解明2023
- Author(s)
  富田泰輔
- Organizer
  令和4年度認知症専門研修会（兵庫県医師会）
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の医療・予防法開発に向けて2023
- Author(s)
  富田泰輔
- Organizer
  EMPセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Illuminating the amyloids by photo-oxygenation strategy against Alzheimer disease.2023
- Author(s)
  富田泰輔
- Organizer
  Sweden-Tokyo University Partnership Workshop Theme1.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病に対する先制医療・予防法の開発に向けて2022
- Author(s)
  富田泰輔
- Organizer
  FDDセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症療法＜神経変性疾患に対する新規治療法開発＞2022
- Author(s)
  富田泰輔
- Organizer
  第129回有機デバイス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Pathological roles of microglial gene INPP5D in a mouse model of Alzheimer disease.2022
- Author(s)
  Sho Takatori, Akihiro Iguchi, Shingo Kimura, Hiroki Muneto, Kai Wang, Hayato Etani, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  ISMND2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症をモデル化する　その現状と限界、将来2022
- Author(s)
  富田泰輔
- Organizer
  ケー・エー・シーKAC　セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 運動プログラムの定期的実施による認知機能改善効果と睡眠関連パラメータに関する観察研究2022
- Author(s)
  蓼沼豊、鈴木宏幸、栢森藍佳、加藤美和子、古奥奈保子、岩中伸幸、千代和弘、鮫島智啓、山本恵里花、中村健太郎、藤原佳典、徳渕慎一郎、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症研究の最前線2022
- Author(s)
  富田泰輔
- Organizer
  岡山大学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病に対する創薬研究2022
- Author(s)
  富田泰輔
- Organizer
  和漢研　生体防御学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Elucidation of pathological roles of INPP5D in Alzheimer disease2022
- Author(s)
  高鳥翔、井口明優、木村新伍、堀由起子、佐々木純子、斉藤貴志、西道隆臣、池津庸哉、高井俊行、佐々木雄彦、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化触媒を用いた新規AD治療戦略の開発2022
- Author(s)
  堀由起子、相馬洋平、金井求、富田泰輔
- Organizer
  第95回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] シヌクレイノパチー治療を目指したα-シヌクレインに対する光酸素化2022
- Author(s)
  中村麗人、堀由起子、富澤郁美、池田哲生、平山皓太、岩井篤志、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] パーキンソン病リスク遺伝子Rab29近傍タンパク質の網羅的同定と機能解析2022
- Author(s)
  徐楽佳、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Inhibition of NF-κB pathway in the astrocytes facilitates the proteolytic clearance of amyloid-β by kallikrein-related peptidase 72022
- Author(s)
  Taisuke Tomita, Yuki Sudo, Kazunori Kikuchi, Chia Jen Sung, Sho Takatori, Yukiko Hori
- Organizer
  Neuroscience 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ミクログリアによるAmyloid-β凝集体貪食機構の解明2022
- Author(s)
  惠谷隼、王文博、高鳥翔、井口明優、富田泰輔
- Organizer
  第２１回次世代を担う若手のためのファーマ・バイオフォーラム2022
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向けて2022
- Author(s)
  富田泰輔
- Organizer
  第37回創薬セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Novel therapeutic strategies for Alzheimer disease by regulation of microglial activities in the brain2022
- Author(s)
  富田泰輔
- Organizer
  第26回グリア研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 非侵襲的光酸素化による脳内タウアミロイドの除去2022
- Author(s)
  堀由起子、鈴木崇允、澤崎鷹、高橋真奈美、田桑弘之、水島昇、樋口真人、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症を克服せよ2022
- Author(s)
  富田泰輔
- Organizer
  洛星高校模擬講義
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Alzheimer disease risk factor TREM2 and INPP5D oppositely regulate microglial uptake of Amyloid beta fibrils2022
- Author(s)
  Hayato Etani, Sho Takatori, Taisuke Tomita
- Organizer
  第26回グリア研究会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Molecular and cellular pathomechanisms of Alzheimer disease.2022
- Author(s)
  富田泰輔
- Organizer
  Serendipity Seminar, The University of Tokyo
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] プロテアーゼを利用したRab29ヌクレオチド結合状態解析系の確立2022
- Author(s)
  梶原陽太郎、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] APP依存的な新規タウ分泌現象の発見2022
- Author(s)
  佐藤玄謙、春日健作、磯尾紀子、林俊宏、堀由起子、池内健、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Molecular mechanisms of microglial response in amyloid-β accumulation in Alzheimer disease.2022
- Author(s)
  富田泰輔
- Organizer
  5th Worldwide conference on GeNeDis2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ミクログリアにおけるTREM2機能新規制御因子の探索と同定2022
- Author(s)
  加藤由真、王文博、高鳥翔、富田泰輔
- Organizer
  第44回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 酸素化Aβ分解プロテアーゼの性状解析2022
- Author(s)
  池田哲生、堀由起子、相馬洋平、金井求、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Alzheimer disease resilience factor RAB10 regulates tau uptake in microglia2022
- Author(s)
  Kai Wang、高鳥翔、富田泰輔
- Organizer
  第41回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] パーキンソン病原因遺伝子LRRK2が引き起こすリソソーム局在変化2022
- Author(s)
  伊藤恭平、荒木美保、片井悠太、西村佑紀、井上晴幾、伊藤弦太、富田泰輔
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 細胞内温度勾配によるTDP-43凝縮体形成機構の解析2022
- Author(s)
  山根大典、寳田雅治、岡部弘基、須藤優喜、船津高志、堀由起子、富田泰輔
- Organizer
  第44回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] INPP5D modulates TREM2 loss-of-function phenotypes in a mouse model of Alzheimer disease.2022
- Author(s)
  Akihiro Iguchi, Sho Takatori, Shingo Kimura, Yukiko Hori, Junko Sasaki, Takashi Saito, Takaomi C Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  CINF2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] LRRK2によるリソソームの細胞内局在制御2022
- Author(s)
  伊藤弦太、伊藤恭平、片井悠太、西村佑紀、井上晴幾、富田泰輔
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化によるアルツハイマー病治療薬の開発2022
- Author(s)
  富田泰輔
- Organizer
  第9回日本アミロイドーシス学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向け2022
- Author(s)
  富田泰輔
- Organizer
  第30回クリニカルファーマシーシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Aβアミロイドーシスとしてのアルツハイマー病に対する創薬研究2022
- Author(s)
  富田泰輔
- Organizer
  第63回日本神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ovel Strategies for Enhanced Amyloid Clearance for Alzheimer Disease.2022
- Author(s)
  富田泰輔
- Organizer
  Seminar at Cellular & Molecular Physiology, Yale University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ADAMTS4 as an enzyme cleaving at APP669 site.2022
- Author(s)
  Naoki Kaneko, Miyabishara Yokoyama, Masaya Matsuzaki, Kentaro Ikemura, Gabriel Opoku, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Satoshi Hirohata, Koichi Tanaka, Taisuke Tomita
- Organizer
  AAIC2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光認知症療法の開発に向けて2022
- Author(s)
  富田泰輔
- Organizer
  第22回日本早期認知症学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 高次構造の異なるαヌクレインは異なる細胞内凝集パターンを形成する2021
- Author(s)
  鵜川佑太、間野達雄、栗原正典、戸田達史、岩田淳、樽谷愛理、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病に対する先制医療・予防法の開発に向けて2021
- Author(s)
  富田泰輔
- Organizer
  FDDセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向けて2021
- Author(s)
  富田泰輔
- Organizer
  EMPセミナー（2021年度下半期）
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Novel strategies for enhanced amyloid clearance in the Alzheimer disease model mice2021
- Author(s)
  Taisuke Tomita
- Organizer
  The 12th BRI International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ADAMTS4 cleaves APP at 669 site to produce APP669-711, a plasma biomarker for amyloid deposition.2021
- Author(s)
  Miyabishara Yokoyama, Naoki Kaneko, Masaya Matsuzaki, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamotor, Koichi Tanaka, Taisuke Tomita
- Organizer
  New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病におけるミクログリア分子病態の解明2021
- Author(s)
  富田泰輔
- Organizer
  第10回日本認知症予防学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] The APP669-711/Aβ1-40 as a plasma biomarker for the brain Aβ deposition in APP/PS1 mouse.2021
- Author(s)
  Naoki Kaneko, Masaya Matsuzaki, Miyabishara Yokoyama, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 運動プログラムの定期的実施による認知機能改善効果と睡眠パラメータに関する観察研究2021
- Author(s)
  蓼沼豊、鈴木宏幸、栢森藍佳、加藤美和子、古奥奈保、岩中伸幸、千代和弘、中村健太郎、藤原佳典、徳渕慎一郎、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 脳内炎症制御による新たな認知症治療戦略2021
- Author(s)
  富田泰輔
- Organizer
  認知症の早期発見、予防・治療研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の予防・治療に向けた創薬研究2021
- Author(s)
  富田泰輔
- Organizer
  第40回日本認知症学会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病におけるアストロサイト由来Aβ分解酵素KLK7の発現制御機構の解明2021
- Author(s)
  宋家禎、須藤優喜、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] INPP5D haplodeficiency rescued TREM2-loss-of-function phenotype of microglia in Alzheimer disease model mice.2021
- Author(s)
  Akihiro Iguchi, Sho Takatori, Shingo Kimura, Yukiko Hori, Junko Sasaki, Takashi Saito, Sakaomi C. Saido, Tsuneya Ikezu, Toshiyuki Takai, Takehiko Sasaki, Taisuke Tomita
- Organizer
  New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 自閉症モデルマウスにおけるシナプス形成異常関連分子Lingo2の代謝機構解析2021
- Author(s)
  熊詩若、吉田文明、伊藤弦太、高鳥翔、富田泰輔
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K21471
[Presentation] アルツハイマー病遺伝学的リスク因子BIN1がタウ蓄積病理および伝播に及ぼす影響の解析2021
- Author(s)
  根本侑、鴇巣正樹、堀由起子、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] パーキンソン病リスク遺伝子Rab29の生化学的解析2021
- Author(s)
  長井ゆき、伊藤弦太、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photo-oxygenation by biocompatible catalyst reduced the Aβ level in the brains of Alzheimer disease model mice.2021
- Author(s)
  Taisuke Tomita, Shuta Ozawa, Nozomu Nagashima, Youhei Sohma, Motomu Kanai, Yukiko Hori
- Organizer
  第44回神経科学大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症治療・予防の最前線2021
- Author(s)
  富田泰輔
- Organizer
  日本抗加齢医学会研修講習会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向けて2021
- Author(s)
  富田泰輔
- Organizer
  EMPセミナー（2021年度上半期）
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 細胞内温度勾配による液液層分離および液固相分離制御機構2021
- Author(s)
  山根大典、岡部弘基、須藤優喜、船津高志、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 自閉症モデルマウスにおけるシナプス形成異常関連分子Lingo2の代謝機構解析2021
- Author(s)
  熊詩若、吉田文明、伊藤弦太、高鳥翔、富田泰輔
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法の開発に向けて2021
- Author(s)
  富田泰輔
- Organizer
  第一回EMPリフレッシュ教育プログラム
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アストロサイト由来Aβ分解酵素Kallikrein-related peptidase 7はNMDA受容体及びNF-κB経路によって発現が制御される2021
- Author(s)
  須藤優喜、木棚究、建部卓也、菊池一徳、堀由起子、高鳥翔、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] The APP669-711/Aβ1-40 ratio as a plasma biomarker specific for the brain Aβ deposition in APP/PS1 mouse.2021
- Author(s)
  Naoki Kaneko, Masaya Matsuzaki, Miyabishara Yokoyama, Akihito Korenaga, Sadanori Sekiya, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita
- Organizer
  AAIC2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photo-oxygenation inhibits tau aggregation and seeding activity.2021
- Author(s)
  Takanobu Suzuki, Yukiko Hori, Taka Sawazaki, Yu Nemoto, Yohei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  New Horizons in Alzheimer's Disease (Hybrid edition)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] グリア細胞を標的とした認知症治療戦略2021
- Author(s)
  富田泰輔
- Organizer
  第21回日本抗加齢医学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症に対する創薬研究の現状と問題点2021
- Author(s)
  富田泰輔
- Organizer
  第28回HAB研究機構学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] BORCS6はLrrk2ノックアウトマウスにおける層板小体肥大化に関与する2021
- Author(s)
  荒木美保、伊藤恭平、高鳥翔、伊藤弦太、富田泰輔
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ミクログリアによるタウ線維の取込みと分泌の分子機構に関する研究2021
- Author(s)
  竹本亮太、高鳥翔、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病治療標的としてのミクログリア生存性回復因子の探索2021
- Author(s)
  加藤由真、高鳥翔、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アミロイドβ蓄積に呼応したミクログリア応答の分子機構解明2021
- Author(s)
  富田泰輔
- Organizer
  第39回日本神経治療学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] LRRK2によるリソソーム局在化制御と生物学的意義2021
- Author(s)
  伊藤弦太、伊藤恭平、富田泰輔
- Organizer
  第40回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Discovery of a novel APP-dependent tau secretion2020
- Author(s)
  Haruaki Sato, Yukiko Hori, Takeshi Ikeuchi, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Pathogenic mechanisms and novel therapeutic approaches for Alzheimer disease2020
- Author(s)
  Taisuke Tomita
- Organizer
  GeNeDis 2020 online
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Novel strategies for enhanced amyloid clearance in the Alzheimer disease brain2020
- Author(s)
  Taisuke Tomita
- Organizer
  The 15th nternational symposium on Geriatrics and Gerontology
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Elucidation of molecular mechanism that induce abnormal excitatory synapse formation in valproic acid-induced rodent model of autism spectrum disorders2020
- Author(s)
  Fumiaki Yoshida, Ryota Nagatomo, Misaki Kimura, Genta Ito, Sho Takatori, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-20K21471
[Presentation] マイクログリアによる光酸素化Aβ代謝促進機構の解明2020
- Author(s)
  小澤柊太、谷口敦彦、清水裕介、王文博、横島聡、福山透、高鳥翔、相馬洋平、金井求、堀由起子、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Identification of ADAMTS4 as an Amyloid Precursor Protein Cleaving Enzyme at 669 Site in APP669-711 Production Pathway2020
- Author(s)
  Taisuke Tomita, Masaya Matsuzaki, Naoki Kaneko, Miyabishara Yokoyama, Yota Yoshizawa, Yusaku Hioki, Shinichi Iwamoto, Koichi Tanaka
- Organizer
  CTAD2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] INPP5D modulates Trem2-loss-of-function phenotype of AD model mice2020
- Author(s)
  井口明優、高鳥翔、木村新伍、佐々木純子、斉藤貴志、西道隆臣、高井俊行、佐々木雄彦、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Enhanced clearance of amyloid proteins by photo-oxygenenation catalyst.2020
- Author(s)
  Taisuke Tomita
- Organizer
  International symposium for Bilateral Joint Research Project between Lithuania and Japan
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] APP依存的な新規タウ分泌現象の発見2020
- Author(s)
  佐藤玄謙、堀由起子、春日健作、池内健、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Elucidation of molecular mechanism that induce abnormal excitatory synapse formation in valproic acid-induced rodent model of autism spectrum disorders2020
- Author(s)
  Fumiaki Yoshida, Ryota Nagatomo, Misaki Kimura, Genta Ito, Sho Takatori, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症を克服せよ：アルツハイマー病の先制医療法開発2020
- Author(s)
  富田泰輔
- Organizer
  五月祭
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photo-oxygenation by biocompatible catalyst reduced the Aβ level in the brains of Alzheimer disease model mice2020
- Author(s)
  Shuta Ozawa, Yukiko Hori, Yusuke Shimizu, Atsuhiko Taniguchi, Takanobu Suzuki, Takashi Saito, Takaomi C. Saido, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の撲滅に向けて＜予防・治療法の開発の現状と未来＞2020
- Author(s)
  富田泰輔
- Organizer
  東京大学ホームカミングデイ
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Pathogenic mechanisms and novel therapeutic approaches for Alzheimer disease2020
- Author(s)
  Taisuke Tomita
- Organizer
  The third interdisciplinary Workshop within the strategic partnership between the University of Tokyo and the Stockholm Trio
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病に対する先制医療・予防法の開発に向けて2020
- Author(s)
  富田泰輔
- Organizer
  FDDセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] マウスにおけるアルツハイマー病血漿バイオマーカー分子APP669-711の解析2020
- Author(s)
  松崎将也、吉澤遥太、横山雅シャラ、菊池一徳、金子直樹、岩本慎一、田中耕一、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Novel strategies for enhanced amyloid clearance in the Alzheimer disease brain2020
- Author(s)
  Taisuke Tomita
- Organizer
  Novel strategies for enhanced amyloid clearance in the Alzheimer disease brain
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] The pathological link of glial pathway with amyloid clearance in Alzheimer disease2020
- Author(s)
  Taisuke Tomita
- Organizer
  第61回日本神経学会学術大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Regulation of intracellular lysosomal positioning by LRRK22020
- Author(s)
  Kyohei Ito, Genta Ito, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Characterization of propagation patterns of distinctive alpha-synuclein strains2020
- Author(s)
  Yanchen Liu, Yuta Ukawa, Tatsuo Mano, Masanori Kurihara, Tatsushi Toda, Atushi Iwata, Airi Tarutani, Taisuke Tomita
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ミクログリアによるアミロイドβ線維貪食機構の解明2020
- Author(s)
  王文博、高鳥翔、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 新規光酸素化触媒による非侵襲的光酸素化反応の確立2020
- Author(s)
  堀由起子、永島臨、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Understanding the molecular microglial pathology in Alzheimer disease2020
- Author(s)
  Taisuke Tomita
- Organizer
  第63回神経化学会大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の予防・治療薬開発に向けた分子細胞病態解明2020
- Author(s)
  富田泰輔
- Organizer
  名古屋市立大学医学部セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の予防・治療薬開発に向けた分子細胞病態解明2020
- Author(s)
  富田泰輔
- Organizer
  名古屋大学環境医学研究所セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病におけるミクログリア分子病態の解明2020
- Author(s)
  富田泰輔
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向けて2020
- Author(s)
  富田泰輔
- Organizer
  東京大学EMP
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病におけるアミロイドβの病的機能解明と治療・予防法開発2020
- Author(s)
  富田泰輔
- Organizer
  首都大学東京セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Identification of ADAMTS4 as an APP-cleaving enzyme at 669 site in APP669-711 production pathway2020
- Author(s)
  Taisuke Tomita, Masaya Matsuzaki, Naoki Kaneko, Miyabishara Yokoyama, Yota Yoshizawa, Shinichi Iwamoto, Koichi Tanaka
- Organizer
  AAIC2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 運動プログラムの定期的実施による認知機能改善効果と睡眠パラメータに関する観察研究2020
- Author(s)
  富田泰輔、蓼沼豊、鈴木宏幸、大島典子、栢森藍佳、加藤美和子、岩中伸幸、中村健太郎、藤原佳典、徳渕慎一郎
- Organizer
  第39回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation by biocompatible catalyst reduces the Aβ level in the brains of Alzheimer disease model mice.2019
- Author(s)
  Taisuke Tomita, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Yukiko Hori
- Organizer
  AD/PD 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病治療を目指した光酸素化触媒によるタウの凝集抑制2019
- Author(s)
  鈴木崇允、堀由起子、澤崎鷹、清水裕介、根本侑、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病治療を目指した光酸素化触媒によるタウアミロイド動態制御2019
- Author(s)
  鈴木崇允、堀由起子、澤崎鷹、清水裕介、根本侑、谷口敦彦、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向けて2019
- Author(s)
  富田泰輔
- Organizer
  旭中央病院臨床病理科・エム・シー・オー・東京大学アイソトープ総合センター秋光研究室合同研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Genome wide screening of genetic factors for tau aggregation2019
- Author(s)
  Taisuke Tomita
- Organizer
  Seminar at Lithuanian University of Health Sciences
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of the genetic regulators for Aβ production by CRISPR/Cas9.2019
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の予防・治療薬開発に向けた分子細胞病態解明2019
- Author(s)
  富田泰輔
- Organizer
  広島大学大学院理学系研究科第14回細胞生物学研究室セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] ミクログリアによるアミロイドβの認識・応答とその分子機構2019
- Author(s)
  高鳥翔、井口明優、木村新伍、佐々木純子、佐々木雄彦、高井俊行、斉藤貴志、西道隆臣、富田泰輔
- Organizer
  Neuro2019
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 脳内アミロイド動態制御によるアルツハイマー病治療法の新展開2019
- Author(s)
  富田泰輔
- Organizer
  関西・中部認知症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Genome-wide screening of genes involved in tau aggregation by CRIPSR/Cas9 system.2019
- Author(s)
  Ihori Ebinuma, Yu Nemoto, Yukiko Hori, Taisuke Tomita
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] シナプス接着分子Neuroligin2切断を介した抑制性シナプス制御機構の解明2019
- Author(s)
  木村美咲、名尾洋介、富田泰輔
- Organizer
  第41回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] バルプロ酸母体投与自閉症モデルマウスにおいて興奮性シナプス形成異常をもたらす分子メカニズムの解明2019
- Author(s)
  吉田文明、長友亮太、木村美咲、伊藤弦太、高鳥翔、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病リスク遺伝子INPP5DがTREM2シグナル伝達において果たす役割の解明2019
- Author(s)
  井口明優、高鳥翔、木村新伍、佐々木純子、斉藤貴志、西道隆臣、高井俊行、佐々木雄彦、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Expression of kallikrein-related peptidase 7, an astrocyte-derived novel amyloid-β degrading protease, is negatively regulated by NMDA receptor and NF-κB signaling pathways.2019
- Author(s)
  Yuki Sudo, Kiwami Kidana, Takuya Tatebe, Yukiko Hori, Sho Takatori, Taisuke Tomita
- Organizer
  IPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Novel strategies for enhanced amyloid clearance in the Alzheimer disease brain2019
- Author(s)
  Taisuke Tomita
- Organizer
  IIIS Seminar
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Systematic analysis on the seeding activity of familial mutant forms of α-synuclein.2019
- Author(s)
  Ning Xu, Genta Ito, Airi Tarutani, Taisuke Tomita
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病血漿バイオマーカー分子APP669-711産生機構の解析2019
- Author(s)
  横山雅シャラ、吉澤遥太、金子直樹、松崎将也、岩本慎一、田中耕一、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Genome-wide screening of genes involved in tau aggregation by CRIPSR/Cas9 system.2019
- Author(s)
  Ihori Ebinuma, Yu Nemoto, Yukiko Hori, Taisuke Tomita
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病遺伝学的リスク因子INPP5Dの病態関与に関する研究2019
- Author(s)
  高鳥翔、井口明優、木村新伍、佐々木純子、佐々木雄彦、高井俊行、斉藤貴志、西道隆臣、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病に対する先制医療・予防法の開発に向けて2019
- Author(s)
  富田泰輔
- Organizer
  FDDセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Elucidation of molecular mechanism that induce abnormal excitatory synapse formation in valproic acid-induced rodent model of autism spectrum disorders.2019
- Author(s)
  Fumiaki Yoshida, Ryota Nagatomo, Misaki Kimura, Genta Ito, Sho Takatori, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の予防・治療薬開発に向けた分子細胞病態解明2019
- Author(s)
  富田泰輔
- Organizer
  OYCバイオシンポジウム2019
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Structural dynamics of presenilin 1, a protein regulating Alzheimer’s disease associated Aβ42 peptide production.2019
- Author(s)
  Tetsuo Cai, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アミロイドβ分解活性新規制御因子GPR120の同定2019
- Author(s)
  菊池一徳、木棚究、堀由起子、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] dentification of genetic regulators for Aβ production by CRISPR/Cas9 based screening.2019
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 脳内アミロイド動態制御によるアルツハイマー病治療法の新展開2019
- Author(s)
  富田泰輔
- Organizer
  新潟認知症セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アミロイドβ分解の新規制御因子GPR120の同定2019
- Author(s)
  菊池一徳、木棚究、堀由起子、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アストロサイト由来Aβ分解酵素Kallikrein-related peptidase 7の発現制御機構の解析2019
- Author(s)
  須藤優喜、木棚究、建部卓也、堀由起子、高鳥翔、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation by biocompatible catalyst reduces the Aβ level in the brains of Alzheimer disease model mice.2019
- Author(s)
  Taisuke Tomita, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Yukiko Hori
- Organizer
  AAIC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病リスク因子TREM2/DAP12と相互作用するタンパク質の解明2019
- Author(s)
  木村新伍、高鳥翔、井口明優、荒木美保、伊藤弦太、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 運動プログラムの定期的実施による認知機能改善効果と睡眠関連パラメータに関する観察研究2019
- Author(s)
  富田泰輔、鈴木宏幸、山本大輔、高藤慎介、中村健太郎、藤原佳典、徳渕慎一郎
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の分子病態解明2019
- Author(s)
  富田泰輔
- Organizer
  第一回島津奨励賞記念講演
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Photooxygenation inhibits tau amyloid formation.2019
- Author(s)
  Yukiko Hori, Takanobu Suzuki, Taka Sawazaki, Yusuke Shimizu, Yu Nemoto, Atsuhiko Taniguchi, Shuta Ozawa, Yohei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Novel strategies for enhanced amyloid clearance in the Alzheimer disease brain.2019
- Author(s)
  Taisuke Tomita
- Organizer
  Edward Koo’s Farewell Symposium at NUS
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Proteomic analysis of lamellar bodies in Lrrk2 knockout mice.2019
- Author(s)
  Miho Araki, Sho Takatori, Genta Ito, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病血漿バイオマーカー分子APP669-711産生責任酵素ADAMTS4の同定2019
- Author(s)
  横山雅シャラ、金子直樹、松崎将也、吉澤遥太、岩本慎一、田中耕一、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation reduces the Aβ level in the brains of Alzheimer disease model mice.2019
- Author(s)
  Yukiko Hori, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] シナプス接着分子Neuroligin2のタンパク質切断を介したGABA作動性シナプスの形成・分解制御機構の解明2019
- Author(s)
  菊池一徳、木棚究、堀由起子、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 光酸素化反応による酸素化Aβの代謝機構の解析2019
- Author(s)
  堀由起子、小澤柊太、清水裕介、谷口敦彦、相馬洋平、金井求、富田泰輔
- Organizer
  第38回日本認知症学会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Transcriptional regulation of kallikrein-related peptidase 7, an astrocyte-derived amyloid-β degrading protease, in the pathogenesis of Alzheimer disease.2019
- Author(s)
  Taisuke Tomita, Yuki Sudo, Kiwami Kidana, Takuya Tatebe, Sho Takatori, Yukiko Hori
- Organizer
  IPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation by biocompatible catalyst reduces the Aβ level in the brains of Alzheimer disease model mice.2019
- Author(s)
  Taisuke Tomita, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Yukiko Hori
- Organizer
  AD/PD 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] マウスにおけるアルツハイマー病血漿バイオマーカー分子APP669-711の産生機構の解明2019
- Author(s)
  松崎将也、金子直樹、吉澤遥太、岩本慎一、田中耕一、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Systematic analysis on the seeding activity of familial mutant forms of α-synuclein.2019
- Author(s)
  Taisuke Tomita, Nung Xu, Airi Tarutani, Genta Ito
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症発症のメカニズムと治療・予防法開発2019
- Author(s)
  富田泰輔
- Organizer
  キャピタルメディカ　セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病発症関連分子Aβ42産生に寄与するPresenilin 1の構造活性相関解明2019
- Author(s)
  蔡哲夫、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向けて2019
- Author(s)
  富田泰輔
- Organizer
  東京大学EMP
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 脳アミロイドクリアランス促進によるアルツハイマー病疾患修飾薬の開発に向けて2019
- Author(s)
  富田泰輔
- Organizer
  AD Medical Symposium 2019
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 脳アミロイドクリアランス促進によるアルツハイマー病疾患修飾薬の開発に向けて2019
- Author(s)
  富田泰輔
- Organizer
  Neurocognitive Impairment Forum
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病の予防・治療薬開発に向けた分子細胞病態解明2019
- Author(s)
  富田泰輔
- Organizer
  第14回小胞体ストレス研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] The effect of synaptic adhesion molecules on in vitro tau propagation model.2019
- Author(s)
  Yu Nemoto, Yukiko Hori, Taisuke Tomita
- Organizer
  Neuroscience 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 画期的アルツハイマー病創薬を目指した光触媒の開発2019
- Author(s)
  富田泰輔
- Organizer
  第二回三融会・武田神経科学シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Novel strategies for enhanced amyloid clearance in the Alzheimer disease brain.2019
- Author(s)
  Taisuke Tomita
- Organizer
  JKiC Seminar “Molecular Mechanisms and Therapeutic Opportunities in Alzheimer’s Disease”
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病リスク遺伝子INPP5DとTREM2シグナルの相互作用解析2019
- Author(s)
  井口明優、高鳥翔、木村新伍、佐々木純子、斉藤貴志、西道隆臣、高井俊行、佐々木雄彦、富田泰輔
- Organizer
  BIOUT
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 層板小体の恒常性維持におけるLRRK2の役割2019
- Author(s)
  伊藤弦太、荒木美保、高鳥翔、富田泰輔
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アミロイドクリアランス促進による認知症疾患修飾薬の開発2019
- Author(s)
  富田泰輔
- Organizer
  第33回老年期認知症研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Novel strategy for enhanced amyloid clearance for therapeutic approach against dementia.2019
- Author(s)
  Taisuke Tomita
- Organizer
  Neuroscience seminar. University of Yamanashi
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] 認知症の先制医療・予防法開発に向けて2019
- Author(s)
  富田泰輔
- Organizer
  EMPセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] Photooxygenation reduces the Aβ level in the brains of Alzheimer disease model mice.2019
- Author(s)
  Yukiko Hori, Shuta Ozawa, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  9th FAOPS Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of ADAMTS4 as an APP-cleaving enzyme at 669 site in APP669-711 production pathway.2019
- Author(s)
  Masaya Matsuzaki, Naoki Kaneko, Miyabishara Yokoyama, Yota Yoshizawa, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita
- Organizer
  IPS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01015
[Presentation] アルツハイマー病モデルマウスにおけるAβアミロイドに対するin vivo光酸素化反応2018
- Author(s)
  堀由起子、金井求、富田泰輔
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] タウ細胞間伝播培養細胞モデルの構築2018
- Author(s)
  根本侑、堀由起子、富田泰輔
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病リスク遺伝子INPP5Dの病理学的役割の解明2018
- Author(s)
  井口明優、高鳥翔、木村新伍、佐々木純子、斉藤貴志、西道隆臣、高井俊行、佐々木雄彦、富田泰輔
- Organizer
  第40回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 光酸素化触媒によるタウの酸素化は凝集を抑制する2018
- Author(s)
  鈴木崇允、堀由起子、澤崎鷹、根本侑、小澤柊太、相馬洋平、金井求、富田泰輔
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病に対する早期診断・先制医療の開発に向けて2018
- Author(s)
  富田泰輔
- Organizer
  第4回トランスレーショナルリサーチ・コロキアム
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 凝集タウ蛋白質を標的とした光酸素化触媒の開発2018
- Author(s)
  澤崎鷹、鈴木崇允、根本侑、小澤柊太、倪積智、堀由起子、富田泰輔、相馬洋平、金井求
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 凝集タウ蛋白質を標的とした光酸素化触媒の開発2018
- Author(s)
  澤崎鷹、鈴木崇允、根本侑、小澤柊太、倪積智、堀由起子、富田泰輔、相馬洋平、金井求
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] LRP1 依存的なアミロイドβ 取り込みを指標とした遺伝学的スクリーニング系の構築2018
- Author(s)
  松田友亨、海老沼五百理、堀由起子、富田泰輔
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来Aβ分解酵素KLK7を創薬標的としたアルツハイマー病治療薬創出2018
- Author(s)
  富田泰輔
- Organizer
  Stockholm-Tokyo University Partnership, Workshop on Active Ageing
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Structure-activity relationship of Alzheimer disease associated protein, Presenilin 1.2018
- Author(s)
  Tetsuo Cai, Taisuke Tomita
- Organizer
  第17回東京大学生命科学シンポジウムBIO UT
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 光酸素化反応系を用いた酸素化Aβの生化学的解析2018
- Author(s)
  堀由起子、小澤柊太、谷口敦彦、清水裕介、城野柳人、齊藤貴志、西道隆臣、相馬洋平、金井求、富田泰輔
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] アルツハイマー病モデルマウスにおけるAβアミロイドに対するin vivo光酸素化反応2018
- Author(s)
  堀由起子、金井求、富田泰輔
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Novel strategies for facilitation of amyloid clearance in the brain.2018
- Author(s)
  Taisuke Tomita
- Organizer
  Targeting Therapy of Alzheimer’s and Related Neurodegenerative Diseases Conference.
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] タウ伝播培養細胞モデルにおけるシナプス接着分子の影響2018
- Author(s)
  根本侑、堀由起子、富田泰輔
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Effect of Genetic Risk Factors for Alzheimer Disease on the Pathological Tau Uptake.2018
- Author(s)
  Taisuke Tomita, Naoki Tsuruya, Yu Nemoto, Yukiko Hori
- Organizer
  AAIC2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Understanding the molecular/cellular pathology and emerging strategies for Alzheimer disease.2018
- Author(s)
  Taisuke Tomita
- Organizer
  2018 KSBNS Annual Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 光酸素化反応系を用いた酸素化Aβの生化学的解析2018
- Author(s)
  堀由起子、小澤柊太、谷口敦彦、清水裕介、城野柳人、齊藤貴志、西道隆臣、相馬洋平、金井求、富田泰輔
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病発症関連分子Aβ42産生に寄与するPresenilin 1の構造活性相関解明2018
- Author(s)
  蔡哲夫、富田泰輔
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Understanding the molecular/cellular pathology and emerging strategies against Alzheimer disease.2018
- Author(s)
  Taisuke Tomita
- Organizer
  Seminar at Lithuanian University of Health Sciences.
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Photooxygenation by biocompatible catalyst reduces the Aβ level in the brains of Alzheimer disease model mice.2018
- Author(s)
  Shuta Ozawa, Yukiko Hori, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] アルツハイマー病の分子病態解明と創薬研究2018
- Author(s)
  富田泰輔
- Organizer
  第2回日本脳神経外科認知症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 認知症治療・予防薬開発の最前線2018
- Author(s)
  富田泰輔
- Organizer
  第2回日本脳神経外科認知症学会学術集会　市民公開講座
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病の発症機構と創薬研究2018
- Author(s)
  富田泰輔
- Organizer
  第17回認知症学会専門医教育セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Emerging roads to novel therapeutics/prevention approaches for Alzheimer disease.2018
- Author(s)
  Taisuke Tomita
- Organizer
  第59回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Phenotypic changes in glial cells in Alzheimer disease.2018
- Author(s)
  Taisuke Tomita
- Organizer
  5th International Conference on Molecular Neurodegeneration.
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Effects of missense mutations associated with neuropsychiatric disorder on the processing and function of synapse adhesion molecule Neuroligin 4X.2018
- Author(s)
  Misaki Kimura, Takafumi Yumoto, Ryota Nagatomo, Yosuke Nao, Taisuke Tomita
- Organizer
  第41回日本神経科学大会（Neuroscience2018）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来Aβ分解酵素Kallikrein-related peptidase 7の発現制御機構の解析2018
- Author(s)
  須藤優喜、木棚究、建部卓也、堀由起子、高鳥翔、富田泰輔
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Photooxygenation by biocompatible catalyst reduces the Aβ level in the brains of Alzheimer disease model mice.2018
- Author(s)
  Shuta Ozawa, Yukiko Hori, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of the genetic regulators for Aβ production by CRISPR/Cas9.2018
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 脳アミロイドクリアランス促進によるアルツハイマー病治療法の新展開2018
- Author(s)
  富田泰輔
- Organizer
  CMB Seminar at Northwestern University.
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Analysis of the amyloid β-related peptides in mouse plasma and cultured cell media.2018
- Author(s)
  Naoki Kaneko, Masaya Matsuzaki, Yota Yoshizawa, Shinichi Iwamoto, Koichi Tanaka, Taisuke Tomita
- Organizer
  AAIC2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 認知症の先制医療・予防法開発に向けて2018
- Author(s)
  富田泰輔
- Organizer
  東京大学EMP
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Education and employment at Graduate school of Pharmaceutical Sciences.2018
- Author(s)
  Taisuke Tomita
- Organizer
  ConBio2017
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 分子・細胞病態に基づく今後の認知症創薬研究の展望2018
- Author(s)
  富田泰輔
- Organizer
  福井の認知症を考える会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 病態に基づく今後の認知症創薬研究の展望2018
- Author(s)
  富田泰輔
- Organizer
  アルツハイマー病発症機構の解明と創薬研究
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] GPR120を介したアミロイドβ分解活性制御機構の解明2018
- Author(s)
  菊池一徳、木棚究、堀由起子、富田泰輔
- Organizer
  第23回日本病態プロテアーゼ学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Understanding the molecular/cellular pathology and emerging strategies for Alzheimer disease.2018
- Author(s)
  Taisuke Tomita
- Organizer
  Neuroscience in Kobe
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] LRRKファミリーキナーゼによるRabリン酸化の解析2018
- Author(s)
  伊藤弦太、富田泰輔
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Analysis of molecular mechanisms of ATP-binding Cassette Transporter A7 (ABCA7) in microglial phagocytosis of Amyloid beta.2018
- Author(s)
  王文博、高鳥翔、富田泰輔
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 層板小体の恒常性維持におけるLRRK2の役割2018
- Author(s)
  荒木美保、高鳥翔、伊藤弦太、富田泰輔
- Organizer
  第41回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] マウスにおけるアルツハイマー病血漿バイオマーカー分子APP669-711の産生機構の解明2018
- Author(s)
  松崎将也、金子直樹、吉澤遥太、岩本慎一、田中耕一、富田泰輔
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] グリア細胞病態の制御によるアルツハイマー病治療戦略2018
- Author(s)
  富田泰輔
- Organizer
  第７回都医学研シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病（AD）におけるRIN3の病態寄与に関する研究2018
- Author(s)
  藤田隆弘、王文博、高鳥翔、富田泰輔
- Organizer
  第40回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 運動プログラムの定期的実施による認知機能および関連パラメータ変化に関する観察研究2018
- Author(s)
  富田泰輔、鈴木宏幸、山本大輔、高藤慎介、中村健太郎、藤原佳典、徳渕慎一郎
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Development of cell-to-cell tau propagation model.2018
- Author(s)
  Yu Nemoto, Yukiko Hori, Taisuke Tomita
- Organizer
  第17回東京大学生命科学シンポジウムBIO UT
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Characterization and inactivation of pathogenic a-synuclein species.2018
- Author(s)
  Airi Tarutani, Tetsuaki Arai, Shigeo Murayama, Shin-ichi Hisanaga, Taisuke Tomita, Masato Hasegawa
- Organizer
  Neuroscience 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] マウスにおけるアルツハイマー病血漿バイオマーカー分子APP669-711の解析2018
- Author(s)
  金子直樹、松崎将也、吉澤遥太、岩本慎一、田中耕一、富田泰輔
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Development of personalized therapeutic/prevention approaches for Alzheimer disease.2018
- Author(s)
  Taisuke Tomita
- Organizer
  Workshop on Biomedical Engineering at Cambridge University
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Understanding the molecular/cellular pathology and emerging strategies for Alzheimer disease2018
- Author(s)
  Taisuke Tomita
- Organizer
  第36回日本認知症学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of genetic regulators for Aβ production by CRISPR/Cas9 based screening.2018
- Author(s)
  Miho Araki, Sho Takatori, Genta Ito, Taisuke Tomita
- Organizer
  平成30年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Effect of Genetic Risk Factors for Alzheimer Disease on the Pathological Tau Uptake.2018
- Author(s)
  Taisuke Tomita, Naoki Tsuruya, Yu Nemoto, Yukiko Hori
- Organizer
  AAIC2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] 認知症の撲滅に向けて2018
- Author(s)
  富田泰輔
- Organizer
  クラーチ溝の口特別講演会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来Aβ分解酵素Kallikrein-related peptidase 7の発現制御機構の解析2018
- Author(s)
  須藤優喜、木棚究、建部卓也、堀由起子、高鳥翔、富田泰輔
- Organizer
  第37回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 脳アミロイドクリアランスの画期的促進法の開発と治療への応用2018
- Author(s)
  富田泰輔
- Organizer
  第18回　認プロFD講演会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Effects of missense variations on the processing and function of synaptic adhesion molecule Neuroligin 4X.2017
- Author(s)
  Misaki Kimura, Takafumi Yumoto, Ryota Nagatomo, Yosuke Nao, Taisuke Tomita
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 脂質メディエーターによるアミロイドβ分解活性の制御機構解明2017
- Author(s)
  菊池一徳、建部卓也、木棚究、堀由起子、有田誠、富田泰輔
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 細胞内局在及びpH環境変化に伴うγセクレターゼ活性変化メカニズムの解析2017
- Author(s)
  畑野阿希、金津邦彦、蔡哲夫、富田泰輔
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病の超早期診断と介入治療戦略2017
- Author(s)
  富田泰輔
- Organizer
  第4回トランスレーショナルリサーチ・コロキアム
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Analysis of molecular mechanisms of ATP-binding Cassette Transporter A7 (ABCA7) in microglial phagocytosis of Amyloid beta.2017
- Author(s)
  王文博、高鳥翔、富田泰輔
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病発症機構の解明と創薬研究における新たな展開2017
- Author(s)
  富田泰輔
- Organizer
  日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 認知症治療薬開発の現状と未来2017
- Author(s)
  富田泰輔
- Organizer
  第７回都医学研シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Aβ分泌機構におけるRab7およびその結合分子群の機能解析2017
- Author(s)
  小座間大翔、川村暢幸、和田戈虹、和田洋、富田泰輔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 凝集タウ蛋白質を標的とした光酸素化触媒の開発2017
- Author(s)
  澤崎鷹、鈴木崇允、根本侑、小澤柊太、倪積智、堀由起子、富田泰輔、相馬洋平、金井求
- Organizer
  第３５回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 伝播能をもつタウの細胞内取り込み評価系の構築2017
- Author(s)
  鶴谷直樹、根本侑、堀由起子、富田泰輔
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] GPR120を介したアミロイドβ分解活性制御機構の解明2017
- Author(s)
  菊池一徳、建部卓也、木棚究、堀由起子、有田誠、富田泰輔
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.2017
- Author(s)
  Taisuke Tomita
- Organizer
  EMBL Symposia 2017 Mechanisms of Neurodegeneration.
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] dentification of genetic regulators for Aβ production by CRISPR/Cas9 based screening.2017
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 糖クリックケミストリーを用いたセクレトーム解析による新規自閉症バイオマーカーの探索2017
- Author(s)
  長友亮太、名尾洋亮、木村美咲、伊藤弦太、高鳥翔、富田泰輔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来Aβ分解酵素KLK7の発現制御機構の解明2017
- Author(s)
  建部卓也、木棚究、堀由起子、斉藤貴志、西道隆臣、富田泰輔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病発症機構と先制医療開発へのアプローチ2017
- Author(s)
  富田泰輔
- Organizer
  New Horizon for Neuroscience「アルツハイマー病の未来予想図」
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Novel approach for anti-amyloid-β therapeutics against Alzheimer disease.2017
- Author(s)
  Taisuke Tomita
- Organizer
  CMB Seminar at Northwestern University.
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of genetic regulators for Aβ production by CRISPR/Cas9 based screening.2017
- Author(s)
  Chiu Yung Wen, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Proteolytic regulation of GABAergic synapse formation by neuroligin-2.2017
- Author(s)
  Taisuke Tomita, Yosuke Nao, Ryota Nagatomo, Kosuke Yamashita, Misaki Kimura
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Effects of missense mutation associated with autism spectrum disorder on the processing and synaptogenic function of Neuroligin 4X.2017
- Author(s)
  Misaki Kimura, Takafumi Yumoto, Ryouta Nagatomo, Yosuke Nao, Taisuke Tomita
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 統合失調症関連遺伝子変異がシナプス接着分子Neuroligin 2に及ぼす影響の解析2017
- Author(s)
  山下耕輔、名尾洋亮、富田泰輔
- Organizer
  第39回神経組織培養研究会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Elucidation of the molecular mechanism of phenylimidazole-type γ-secretase modulator E2012.2017
- Author(s)
  蔡哲夫、富田泰輔
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Novel Aβ degrading enzyme and astrocytes.2017
- Author(s)
  Taisuke Tomita
- Organizer
  The 26th Adler Symposium will focus on four major themes: potential role of lifestyle in neurodegeneration.
- Place of Presentation
  Salk Institute（San Diego, USA）
- Year and Date
  2017-02-06
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Biochemical analysis of oxygenated Aβ by photooxygenation system.2017
- Author(s)
  Yukiko Hori, Shuta Ozawa, Atsuhiko Taniguchi, Yusuke Shimizu, Ryuto Kino, Takashi Saito, Takaomi C. Saido, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Regulation of amyloid-β degrading activity by GPR120 signaling.2017
- Author(s)
  Kazunori Kikuchi, Takuya Tatebe, Kiwami Kidana, Yukiko Hori, Makoto Arita, Taisuke Tomita
- Organizer
  10th General meeting of the international proteolysis society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Development of personalized therapeutic/prevention approaches for Alzheimer disease.2017
- Author(s)
  Taisuke Tomita
- Organizer
  Stockholm-Tokyo University Partnership, Workshop on Active Ageing
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] CRISPR/Cas9システムによるAβ取り込み経路関連分子のゲノムワイドスクリーニング2017
- Author(s)
  海老沼五百理、堀由起子、富田泰輔、富田泰輔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Neuroliginのプロセシングによる抑制性シナプス形成制御と精神疾患発症メカニズム2017
- Author(s)
  富田泰輔
- Organizer
  第40回日本神経科学大会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病発症機構の解明と創薬研究における新たな展開2017
- Author(s)
  富田泰輔
- Organizer
  第59回歯科基礎医学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] ミクログリアにおけるABCA7を介したA?貪食機構の解明2017
- Author(s)
  王文博、高鳥翔、富田泰輔
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Analysis of the effects of INPP5D/SHIP1 deficiency on amyloid pathology in Alzheimer model mice.2017
- Author(s)
  Sho Takatori, Shingo Kimura, Junko Sasaki, Takashi Saito, Takaomi C Saido, Takehiko Sasaki, Taisuke Tomita
- Organizer
  EMBL Symposia 2017 Mechanisms of Neurodegeneration
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病血漿バイオマーカー分子APP669-711産生機構の解析2017
- Author(s)
  吉澤遥太、金子直樹、岩本慎一、田中耕一、富田泰輔
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 光酸素化反応系を用いた酸素化Aβの生化学的解析2017
- Author(s)
  堀由起子、小澤柊太、谷口敦彦、清水裕介、城野柳人、齊藤貴志、西道隆臣、相馬洋平、金井求、富田泰輔
- Organizer
  第３５回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] 凝集タウ蛋白質を標的とした光酸素化触媒の開発2017
- Author(s)
  澤崎鷹、鈴木崇允、根本侑、小澤柊太、倪積智、堀由起子、富田泰輔、相馬洋平、金井求
- Organizer
  第３５回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] ミクログリアにおけるABCA7を介したAβ貪食機構2017
- Author(s)
  王文博、高鳥翔、富田泰輔
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Activation of γ-secretase trimming activity by topological changes of transmembrane domain 1 of presenilin 1.2017
- Author(s)
  Tetsuo Cai, Masahiro Yonaga, Taisuke Tomita
- Organizer
  10th General meeting of the international proteolysis society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.2017
- Author(s)
  Taisuke Tomita
- Organizer
  Tohoku Forum on Aging Science
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 光酸素化反応系を用いた酸素化Aβの生化学的解析2017
- Author(s)
  小澤柊太、谷口敦彦、清水裕介、城野柳人、齊藤貴志、西道隆臣、相馬洋平、堀由起子、金井求、富田泰輔
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] 光酸素化反応系を用いた酸素化Aβの生化学的解析2017
- Author(s)
  小澤柊太、谷口敦彦、清水裕介、城野柳人、齊藤貴志、西道隆臣、相馬洋平、堀由起子、金井求、富田泰輔
- Organizer
  第36回日本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病における小胞輸送経路の分子病態2017
- Author(s)
  富田泰輔
- Organizer
  第36回日本認知症学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Biochemical analysis of oxygenated Aβ by photooxygenation system.2017
- Author(s)
  小澤柊太、谷口敦彦、清水裕介、城野柳人、齊藤貴志、西道隆臣、相馬洋平、堀由起子、金井求、富田泰輔
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病におけるプロテオスタシス異常の解明2017
- Author(s)
  富田泰輔
- Organizer
  第20回認知症を語る会
- Place of Presentation
  エーザイ（株）（東京都新宿区）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Biochemical analysis of oxygenated Aβ by photooxygenation system.2017
- Author(s)
  Yukiko Hori, Shuta Ozawa, Atsuhiko Taniguchi, Yusuke Shimizu, Ryuto Kino, Takashi Saito, Takaomi C. Saido, Youhei Sohma, Motomu Kanai, Taisuke Tomita
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19480
[Presentation] Biochemical analysis of oxygenated Aβ by in vivo photooxygenation system.2017
- Author(s)
  Shuta Ozawa, Atsuhiko Taniguchi, Ryuto Kino, Takashi Saito, Takaomi C. Saido, Youhei Sohma, Yukiko Hori, Motomu Kanai and Taisuke Tomita
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 自閉症スペクトラム変異がシナプス接着分子Neuroligin 4X の代謝及び機能に及ぼす影響の解析2017
- Author(s)
  木村美咲、湯本貴文、長友亮太、名尾洋亮、富田泰輔
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.2017
- Author(s)
  Taisuke Tomita
- Organizer
  BRI International Symposium 2017
- Place of Presentation
  新潟大学（新潟県新潟市）
- Year and Date
  2017-03-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 光酸素化反応系を用いた酸素化Aβの生化学的解析2017
- Author(s)
  堀由起子、小澤柊太、谷口敦彦、清水裕介、城野柳人、齊藤貴志、西道隆臣、相馬洋平、金井求、富田泰輔
- Organizer
  第３５回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 脳内アミロイド病態を制御する新規アストロサイト由来プロテアーゼKLK7の同定2016
- Author(s)
  富田泰輔
- Organizer
  放医研セミナー
- Place of Presentation
  放射線医学総合研究所（千葉県千葉市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Kallikrein-related peptidase 7 is a novel amyloid-β peptide-degrading protease secreted from astrocytes.2016
- Author(s)
  Kazunori Kikuchi, Kiwami Kidana, Takuya Tatebe, Yukiko Hori, Taisuke Tomita
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Place of Presentation
  東京大学駒場キャンパス（東京都目黒区）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病リスク遺伝子INPP5Dの機能解明2016
- Author(s)
  木村新伍、高鳥翔、堀由起子、佐々木純子、佐々木雄彦、斉藤貴志、西道隆臣、富田泰輔
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] EphA4を介したアルツハイマー病原因物質Aβ産生量制御機構の解明2016
- Author(s)
  田村謙典、堀由起子、富田泰輔
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病発症における脳内プロテオスタシス異常の分子機構解明2016
- Author(s)
  富田泰輔
- Organizer
  第38回神経組織培養研究会
- Place of Presentation
  横浜ランドマークタワー（神奈川県横浜市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] The Inhibitory effect of memantine on the production of Aβ peptides.2016
- Author(s)
  Kaori Ito, Takuya tatebe, Kunimichi Suzuki, Taisuke Tomita, Mitsuhiro Makino
- Organizer
  AAIC2016
- Place of Presentation
  Metro Tronto Convention Center（Toronto, Canada）
- Year and Date
  2016-07-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 新規アストロサイト由来アミロイドβ分解酵素Kallikrein-related peptidase 7の同定と解析2016
- Author(s)
  菊池一徳、木棚究、建部卓也、堀由起子、富田泰輔
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Analysis of the pathological role of an Alzheimer’s disease genetic risk factor, INPP5D/SHIP1.2016
- Author(s)
  Sho Takatori, Shingo Kimura, Takashi Saito, Takaomi C. Saido, Junko Sasaki, Takehiko Sasaki, Taisuke Tomita
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Effects of missense mutations associated with autism spectrum disorder on the processing and function of synaptic adhesion molecule Neuroligin 4X.2016
- Author(s)
  Misaki Kimura, Takafumi Yumoto, Ryota Nagatomo, Yosuke Nao, Taisuke Tomita
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Place of Presentation
  東京大学駒場キャンパス（東京都目黒区）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.2016
- Author(s)
  Taisuke Tomita
- Organizer
  56th Advances in Biological Regulation
- Place of Presentation
  University of Bologna（Bologna, Italy）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] γセクレターゼモジュレーターE2012の作用機序解明2016
- Author(s)
  蔡哲夫、富田泰輔
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病に対する先制医療法開発に向けて2016
- Author(s)
  富田泰輔
- Organizer
  埼玉認知症研究会
- Place of Presentation
  パレスホテル大宮（埼玉県さいたま市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Retromer and Rab2-dependent trafficking are involved in PS1 degradation by proteasomes in endocytic disturbance.2016
- Author(s)
  Nobuyuki Kimura, Noya Ueda, Taisuke Tomita, Katsuhiko Yanagisawa
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego Convetion Center（San Diego, USA）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of genetic regulators for Aβ production by CRISPR/Cas9 based screening.2016
- Author(s)
  Yung Wen Chiu, Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  第38回神経組織培養研究会
- Place of Presentation
  横浜ランドマークタワー（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Genome wide screening of molecules involved in Aβ uptake by CRIPSR/Cas9 system.2016
- Author(s)
  Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego Convention Center（San Diego, USA）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15229
[Presentation] Pathological impact of astrocyte-mediated proteolytic processing on amyloid-beta deposition.2016
- Author(s)
  Taisuke Tomita
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego Convetion Center（San Diego, USA）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 膜内配列切断活性を制御するプレセニリンの構造ダイナミクスの解明2016
- Author(s)
  富田泰輔
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] EphA4を介したアルツハイマー病原因物質Aβ産生量制御機構の解明2016
- Author(s)
  田村謙典、堀由起子、富田泰輔
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Place of Presentation
  東京大学駒場キャンパス（東京都目黒区）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] EphA4を介したアルツハイマー病原因物質Aβ産生量制御機構の解明2016
- Author(s)
  田村謙典、堀由起子、富田泰輔
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来新規アミロイドβタンパク質分解酵素KLK7の病的機能解明2016
- Author(s)
  建部卓也、木棚究、菊池一徳、堀由起子、秋下雅弘、大内尉義、岩坪威、西道隆臣、富田泰輔
- Organizer
  薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来Aβ分解酵素KLK7の発現制御・活性化機構の解明2016
- Author(s)
  建部卓也、木棚究、堀由起子、富田泰輔
- Organizer
  第35回日本認知症学会学術集会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-12-01
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来プロテアーゼKLK7によって制御される脳内Aβ分解メカニズムの解明2016
- Author(s)
  富田泰輔
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of kallikrein-related peptidase 7 as a novel amyloid-β peptide-degrading protease secreted from astrocyte.2016
- Author(s)
  Taisuke Tomita, Kiwami Kidana, Takuya Tatebe, Kazunori Kikuchi, Takeshi Ikeuchi, Takaomi Saido, Masahiro Akishita, Takeshi Iwatsubo and Yukiko Hori
- Organizer
  IUBMB symposium (XVth International symposium) on Proteases, Inhibitors and Biological Control.
- Place of Presentation
  Bernadian Resort and Conference Center（Portoroz, Slovenia）
- Year and Date
  2016-09-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Analysis of functional significance of phosphoinositide phosphatase INPP5D in the pathogenesis of Alzheimer disease.2016
- Author(s)
  Shingo Kimura, Sho Takatori, Yukiko Hori, Taisuke Tomita
- Organizer
  第16回東京大学生命科学シンポジウムBIO UT
- Place of Presentation
  東京大学駒場キャンパス（東京都目黒区）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Genome wide screening of molecules involved in Aβ uptake by CRIPSR/Cas9 system.2016
- Author(s)
  Ihori Ebinuma, Yukiko Hori, Taisuke Tomita
- Organizer
  Neuroscience 2016
- Place of Presentation
  San Diego Convetion Center（San Diego, USA）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] γセクレターゼモジュレーターE-2012の作用機序解明2016
- Author(s)
  蔡哲夫、富田泰輔
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of KLK7 as a novel amyloid-β peptide-degrading prteiase secreted from astrocytes.2016
- Author(s)
  Takuya Tatebe, Kiwami Kidana, Yukiko Hori, Taisuke Tomita
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来新規アミロイドβタンパク質分解酵素KLK7の病的機能解明2016
- Author(s)
  建部卓也、木棚究、菊池一徳、堀由起子、秋下雅弘、大内尉義、岩坪威、西道隆臣、富田泰輔
- Organizer
  薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] Effects of missense mutations associated with autism spectrum disorder on the processing and function of synaptic adhesion molecule Neuroligin 4X.2016
- Author(s)
  Misaki Kimura, Takafumi Yumoto, Yosuke Nao, Taisuke Tomita
- Organizer
  第39回日本神経科学大会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Pathophysiological Impact of Astrocyte-Derived Kallikrein-Related Peptidase 7 on Aβ Metabolism in Brain.2015
- Author(s)
  Taisuke Tomita, Kiwami Kidana, Takuya Tatebe, Yasuyoshi Ouchi, Masahiro Akishita and Takeshi Iwatsubo
- Organizer
  AAIC2015
- Place of Presentation
  Washington Convention Center（Washington DC, USA）
- Year and Date
  2015-07-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病に対する先制治療法の開発に向けて2015
- Author(s)
  富田泰輔
- Organizer
  東京都医学研セミナー
- Place of Presentation
  東京
- Year and Date
  2015-03-31
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] 遺伝学的アルツハイマー病危険因子の分子病態解明と先制医療の開発2015
- Author(s)
  富田泰輔
- Organizer
  長寿研シンポジウム「アルツハイマー病先制治療薬の創出」
- Place of Presentation
  名古屋
- Year and Date
  2015-01-17
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] 認知症の克服に関する研究について2015
- Author(s)
  富田泰輔
- Organizer
  脳科学の新しい推進プログラムに関する検討会
- Place of Presentation
  東京大学医学部鉄門記念講堂（東京都文京区）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来新規Aβ分解酵素KLK7の同定と解析2015
- Author(s)
  木棚究、建部卓也、富田泰輔
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーション青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] Partial loss of CALM function impacts on the γ-secretase-mediated Aβ42 production and amyloid deposition in vivo.2015
- Author(s)
  Kunihiko Kanatsu, Yukiko Hori, Toshio Watanabe, Takeshi Iwatsubo, Taisuke Tomita
- Organizer
  9th General Meeting of the International Proteolysis Society
- Place of Presentation
  Golden Sands Hotel Conference Center（Penang, Malaysia）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Identification of kallikrein-related peptidase 7 as a novel amyloid-β peptide-degrading protease secreted from astrocytes2015
- Author(s)
  Takuya Tatebe, Kiwami Kidana, Yukiko Hori, Yasuyoshi Ouchi, Masahiro Akishita, Takeshi Iwatsubo, Taisuke Tomita
- Organizer
  第15回東京大学生命科学シンポジウムBIO UT
- Place of Presentation
  東京大学本郷キャンパス（東京都文京区）
- Year and Date
  2015-06-27
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] Astrocyte-mediated proteolytic mechanism regulates amyloid-β metabolism in brain.2015
- Author(s)
  Taisuke Tomita
- Organizer
  Cambridge - U Tokyo workshop
- Place of Presentation
  University of Cambridge（Cambridge, UK）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アストロサイト由来新規アミロイドβタンパク質分解酵素KLK7の病的機能解明2015
- Author(s)
  建部卓也、木棚究、菊池一徳、堀由起子、秋下雅弘、大内尉義、岩坪威、西道隆臣、富田泰輔
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス（千葉県千葉市）
- Year and Date
  2015-09-15
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] アストロサイト由来新規アミロイドβタンパク質分解酵素KLK7の病的機能解明2015
- Author(s)
  建部卓也、木棚究、菊池一徳、堀由起子、秋下雅弘、大内尉義、岩坪威、西道隆臣、富田泰輔
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻地区薬学キャンパス（千葉県千葉市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病予防・治療法におけるγセクレターゼ活性制御2015
- Author(s)
  富田泰輔
- Organizer
  第33回神経治療学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-11-29
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] γセクレターゼによる膜内配列が切断されるメカニズム2015
- Author(s)
  富田泰輔
- Organizer
  日本細胞生物学会大会
- Place of Presentation
  タワーホール船堀（東京都江戸川区）
- Invited
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] EphA4を介したアルツハイマー病原因物質Aβ産生量制御機構の解明2015
- Author(s)
  田村謙典、堀由起子、富田泰輔
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻地区薬学キャンパス（千葉県千葉市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Astrocyte-mediated proteolytic mechanism regulates amyloid-β metabolism in brain.2015
- Author(s)
  Taisuke Tomita
- Organizer
  Cambridge - U Tokyo workshop
- Place of Presentation
  Cambridge（UK）
- Year and Date
  2015-11-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] IDENTIFICATION OF KLK7 AS A NOVEL AMYLOID-β PEPTIDE-DEGRADING PROTEASE SECRETED FROM ASTROCYTES2015
- Author(s)
  Takuya Tatebe, Kiwami Kidana, Yukiko Hori, Masahiro Akishita, Yasuyoshi Ouchi, Takeshi Iwatsubo, Taisuke Tomita
- Organizer
  The 6th annual International Symposium on Kallikreins and Kallikrein-Related Peptidases
- Place of Presentation
  Translational Research Institute（Brisbane, Australia）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] アルツハイマー病に対する先制治療法の開発に向けて2015
- Author(s)
  富田泰輔
- Organizer
  京都大学再生医科学研究所　再生増殖制御学セミナー
- Place of Presentation
  京都
- Year and Date
  2015-02-04
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] 遺伝学的アルツハイマー病リスク因子の分子病態解明2015
- Author(s)
  富田泰輔
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.2015
- Author(s)
  Taisuke Tomita
- Organizer
  9th General Meeting of the International Proteolysis Society
- Place of Presentation
  Golden Sands Hotel Conference Center（Penang, Malaysia）
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 遺伝学的アルツハイマー病リスク因子の分子病態解明2015
- Author(s)
  富田泰輔
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.2015
- Author(s)
  Taisuke Tomita
- Organizer
  9th General Meeting of the International Proteolysis Society
- Place of Presentation
  Penang（Malaysia）
- Year and Date
  2015-10-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] アストロサイト由来新規Aβ分解酵素KLK7の同定と解析2015
- Author(s)
  木棚究、建部卓也、富田泰輔
- Organizer
  第34回日本認知症学会学術集会
- Place of Presentation
  リンクステーションホール青森（青森県青森市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] フェニルイミダゾール型γセクレターゼモジュレーターE-2012の作用機序解明2015
- Author(s)
  蔡哲夫、富田泰輔
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻地区薬学キャンパス（千葉県千葉市）
- Data Source
  KAKENHI-PROJECT-15H02492
[Presentation] 認知症の撲滅：アルツハイマー病に対する先制治療薬開発に向けて2015
- Author(s)
  富田泰輔
- Organizer
  日本薬学会東海支部特別講演会（名古屋市立大学）
- Place of Presentation
  名古屋
- Year and Date
  2015-01-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] グリア系培養細胞上清中に含まれるセリンプロテアーゼ様Aβ分解活性の解析2014
- Author(s)
  建部卓也、木棚究、秋下雅弘、大内尉義、富田泰輔、岩坪威
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県、熊本市
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] 細胞内小胞輸送を介したAβ産生制御機構の解明2014
- Author(s)
  小島良太、宮川統爾、諸橋雄一、辻省次、富田泰輔、岩坪威
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県、熊本市
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] 自閉症関連分子Neuroliginのプロテアーゼによる代謝と機能制御2014
- Author(s)
  名尾洋亮、塩原梓、湯本貴文、富田泰輔、岩坪威
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県、熊本市
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Activity-dependent proteolytic processing of synaptic adhesion molecules.2014
- Author(s)
  Taisuke Tomita, Takafumi Yumoto, Yousuke Nao
- Organizer
  Proteases at work: cues for understanding neural development and degeneration
- Place of Presentation
  Baeza, Spain
- Year and Date
  2014-10-23
- Invited
- Data Source
  KAKENHI-PROJECT-26670035
[Presentation] Activity-dependent proteolytic processing and neurodegenerative diseases.2014
- Author(s)
  Taisuke Tomita
- Organizer
  マックスプランク協会合同シンポジウム
- Place of Presentation
  Jupiter, USA
- Year and Date
  2014-05-10
- Invited
- Data Source
  KAKENHI-PROJECT-26670035
[Presentation] Proteolytic cleavage of inhibitory synapse specific adhesion molecule neuroligin-22014
- Author(s)
  Yosuke Nao, Azusa Shiohara, Takafumi Yumoto, Takeshi Iwatsubo, Taisuke Tomita
- Organizer
  Proteases at work: cues for understanding neural development and degeneration
- Place of Presentation
  Baeza, Spain
- Year and Date
  2014-10-23
- Data Source
  KAKENHI-PROJECT-26670035
[Presentation] Functional analysis of Aβ-degrading serine protease activity in the supernatant from astrocytic cells.2014
- Author(s)
  Takuya Tatebe, Kiwami Kidana, Masahiro Akishita, Yasuyoshi Ouchi, Takeshi Iwatsubo, Taisuke Tomita
- Organizer
  Neuroscience 2014
- Place of Presentation
  Washington DC, USA
- Year and Date
  2014-11-19
- Data Source
  KAKENHI-PUBLICLY-26111705
[Presentation] Physiological and pathological roles of proteolytic processing of autism-related neuroligin proteins2014
- Author(s)
  Taisuke Tomita
- Organizer
  RIKEN BSI seminar
- Place of Presentation
  Wako, Japan
- Year and Date
  2014-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-26670035
[Presentation] Identification of the structural change of Presenilin 1 associated with altered Abeta42 production.2013
- Author(s)
  Aya Tominaga, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  CSH - ASIA Meeting, MEMBRANE PROTEIN STRUCTURE & FUNCTION
- Place of Presentation
  Suzhou, China
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] グリア系培養細胞上清中に含まれるセリンプロテアーゼ様Aβ分解活性の解析2013
- Author(s)
  木棚究、秋下雅弘、大内尉義、富田泰輔、岩坪威
- Organizer
  第32回日本認知症学会学術集会
- Place of Presentation
  長野県、松本市
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Molecular mechanism of phenylimidazole-type gamma-secretase modulators.2013
- Author(s)
  Taisuke Tomita, Koji Takeo, Shun Tanimura, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo
- Organizer
  CSH - ASIA Meeting, MEMBRANE PROTEIN STRUCTURE & FUNCTION
- Place of Presentation
  Suzhou, China
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Molecular mechanism of phenylimidazole-type gamma-secretase modulators.2013
- Author(s)
  Taisuke Tomita, Koji Takeo, Shun Tanimura, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] セクレターゼ活性の制御によるアルツハイマー病治療薬開発2013
- Author(s)
  富田泰輔
- Organizer
  第29回高峰カンファレンス
- Place of Presentation
  東京
- Year and Date
  2013-03-01
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] アルツハイマー病：遺伝学的・環境的リスク因子に関する実験的検証の現況2013
- Author(s)
  岩坪威、橋本唯史、若林朋子、富田泰輔、諸橋雄一
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京都、千代田区
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Hydrophilic loop 1 and the C terminus of presenilin 1 are involved in the initial substrate binding of the gamma-secretase.2013
- Author(s)
  Tomita T
- Organizer
  AD/PD 2013
- Place of Presentation
  Florence, Italy
- Year and Date
  2013-03-06
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] For the study of human cerebral neurodegeneration.2013
- Author(s)
  Taisuke Tomita
- Organizer
  Neuro2013
- Place of Presentation
  京都府、京都市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] セクレターゼ活性の制御とシナプス機能の分子連関2013
- Author(s)
  富田泰輔
- Organizer
  日本薬学会133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24659028
[Presentation] CALM impacts on Abeta42 production ratio through modulation of clathrin-mediated endocytosis of gamma-secretase.2013
- Author(s)
  Kunihiko Kanatsu, Yuichi Morohashi, Toshio Watanabe, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  Neuroscience 2013
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Pathophysiological role of proteolytic cleavage of Neuroligins.2013
- Author(s)
  Taisuke Tomita, Kunimichi Suzuki, Azusa Shiohara, Satoko Osawa, Takeshi Iwatsubo
- Organizer
  AAIC2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Development of preemptive medicine for Alzheimer disease based on molecular basis of Abeta production and synaptic toxicity.2013
- Author(s)
  Taisuke Tomita
- Organizer
  Symposium “Memory Traces and Tags”
- Place of Presentation
  Queretaro, Mexico
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Modulation of BACE1 activitiy by membrane environment.2013
- Author(s)
  Taisuke Tomita
- Organizer
  Kloster Seeon Meeting on BACE Proteases in Health and Disease
- Place of Presentation
  Bavaria, Germany
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Mechanistic insight of the gamma-secretase-mediated intramembrane cleavage.2013
- Author(s)
  Taisuke Tomita
- Organizer
  8th General Meeting of the International Proteolysis Society.
- Place of Presentation
  Cape Town, South Africa
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Biology of gamma-secretase.2013
- Author(s)
  Taisuke Tomita
- Organizer
  11th World Congress of Biological Psychiatry
- Place of Presentation
  京都府、京都市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] FTY720/Fingolimod, a sphingosine analogue, reduces amyloid-beta production in neurons.2013
- Author(s)
  Nobumasa Takasugi, Tomoki Sasaki, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  AAIC2013
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] The alpha-helical structure of the hydrophilic loop 1 of presenilin 1 contributes to the formation of the substrate binding site2012
- Author(s)
  Taisuke Tomita
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-24659028
[Presentation] PICALM regulates Abeta42 production by modulation of gamma-secretase trafficking.2012
- Author(s)
  Tomita T
- Organizer
  AAIC 2012
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2012-07-14
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Activity-dependent proteolytic cleavage of Neuroligin 12012
- Author(s)
  Taisuke Tomita, Kunimichi Suzuki, Takeshi Iwatsubo
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Fukuoka, Japan
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-24659028
[Presentation] γセクレターゼ抑制薬2012
- Author(s)
  富田泰輔
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Year and Date
  2012-10-26
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] ガンマセクレターゼ阻害フォルダマーの構造活性相関研究2012
- Author(s)
  今村優希、大沢智子、梅澤直樹、富田泰輔、岩坪威、加藤信樹、樋口恒彦
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] The alpha-helical structure of the hydrophilic loop1 of presenilin 1 contributes to the formation of the substrate binding site.2012
- Author(s)
  Tomita T
- Organizer
  Neuroscience 2012
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24659028
[Presentation] Development of pre-emptive medicine for Alzheimer disease based on molecular basis of Abeta production.2012
- Author(s)
  Tomita T
- Organizer
  The 17th Takeda Science Foundation Symposium on Bioscience.
- Place of Presentation
  Osaka
- Year and Date
  2012-10-06
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] gamma-secretase活性中心サブユニットPresenilin1の第4膜貫通領域の構造解析2012
- Author(s)
  富永綾、富田泰輔、岩坪威
- Organizer
  第31回日本認知症学会学術集会
- Place of Presentation
  つくば
- Year and Date
  2012-10-26
- Data Source
  KAKENHI-PROJECT-24659028
[Presentation] γセクレターゼ活性制御機構の理解に基づいたアルツハイマー病治療薬開発2012
- Author(s)
  富田泰輔
- Organizer
  第53回日本神経学会学術集会
- Place of Presentation
  東京
- Year and Date
  2012-05-20
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] 認知症への先制医療：アミロイド蓄積をいつ、どのように防ぐか2012
- Author(s)
  富田泰輔
- Organizer
  第34回日本生物学的精神医学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2012-09-29
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Activity-dependent proteolytic cleavage of Neuroligin 1.2012
- Author(s)
  Tomita T
- Organizer
  The 35th Annual Meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Fukuoka
- Invited
- Data Source
  KAKENHI-PROJECT-24659028
[Presentation] The role of phosphatidylinositol binding clathrin assembly protein (PICALM) in the metabolism of amyloid precursor protein2011
- Author(s)
  Kunihiko Kanatsu, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  第30回内藤カンファレンス生体膜ダイナミクスと脂質生物学[II]脂質ドメイン、脂肪滴、疾患
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] γ-Secretase interacting tetraspanin protein CD81 is involved in the internalization of the γ-secretase and its substrates to the endocytic compartment2011
- Author(s)
  Sho Takatori, Ikuo Hayashi, Takeshi Kawamura, Tatsuhiko Kodama, Takao Hamakubo, Takeshi Iwatsubo, Taisuke Tomita
- Organizer
  第30回内藤カンファレンス生体膜ダイナミクスと脂質生物学[II]脂質ドメイン、脂肪滴、疾患
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure and function relationship of the β- and γ-secretases toward development of treatment of Alzheimer disease2011
- Author(s)
  Taisuke Tomita
- Organizer
  7th Fabisch-Symposiumfor Cancer Research and Molecular Cell Biology
- Place of Presentation
  Potsdam, Germany(招待講演)
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure-functionrelationship ofγ-secretase2011
- Author(s)
  Tomita T
- Organizer
  2011 International Conference on Molecular Neurodegeneration
- Place of Presentation
  Shanghai, China
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] BACE1 activity is modulated by cell-associated sphingosine-1-phosphate2011
- Author(s)
  Taisuke Tomita, Nobumasa Takasugi, Tomoki Sasaki, Satoko Osawa, Satoshi Yokoshima, Tohru Fukuyama, Virginia Lee, John Trojanowski, Takeshi Iwatsubo
- Organizer
  The Alzheimer's Association International Conference on Alzheimer's Disease (ICAD) 2011
- Place of Presentation
  Paris, France
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Identification and functional analysis of a genetic regulator for γ-secretase substrate trafficking2011
- Author(s)
  一色隼人、山下雄大、石渡智之、諸橋雄一、富田泰輔、岩坪威
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] PICALM impacts the production and secretion of Aβ42 in cultured cells2011
- Author(s)
  Yuichi Morohashi, Kunihiko Kanatsu, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Functional analysis of sft-4 in the C.elegans Notch pathway2011
- Author(s)
  Tomoyuki Ishiwata, Hayato Isshiki, Tomoki Kuwahara, Yuichi Morohashi, Shohei Mitani, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  第6回日本Notch研究会
- Place of Presentation
  野田
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Notchのγセクレターゼ切断を制御するXPR1の機能解析2011
- Author(s)
  山下雄大、一色隼人、諸橋雄一、富田泰輔、岩坪威
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structural analysis of transmembrane domain 4 of Presenilin 1, a catalytic subunit of γ-secretase2011
- Author(s)
  Aya Tominaga, Shizuka Takagi, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Molecular target of phenylimidazole-type γ-secretase modulators2011
- Author(s)
  Koji Takeo, Shun Tanimura, Ivan Krasimirov Zahariev, Satoshi Yokoshima, Tohru Fukuyama, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  第6回日本Notch研究会
- Place of Presentation
  野田
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure-function relationship of γ-secretase2011
- Author(s)
  Taisuke Tomita
- Organizer
  2011 International Conference on Molecular Neurodegeneration
- Place of Presentation
  Shanghai, China(招待講演)
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] 光親和性標識を用いたフェニルイミダゾール型γセクレターゼモジュレーターの作用標的分子の同定2011
- Author(s)
  竹尾浩史、谷村瞬、ザハリエブイヴァンクラスイミロブ、横島聡、福山透、富田泰輔、岩坪威
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure and functionrelationship of theυ-and-secretasestoward development of treatment ofAlzheimer disease2011
- Author(s)
  Tomita T
- Organizer
  7th Fabisch-Symposium for Cancer Research and Molecular Cell Biology : Regulated Intramembrane Proteolysisin Cancer Development and Neurodegenerative Diseases
- Place of Presentation
  Potsdam, Germany
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] γ-Secretase modulator GSM-1 directly targets the N-terminal fragment of presenilin 1.2011
- Author(s)
  Taisuke Tomita
- Organizer
  The 10th International Congress on Alzheimer's & Parkinson,s Diseases
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2011-03-11
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Notch-Notch ligand interactions modulate the levels of synaptic vesicle proteins in neurons2011
- Author(s)
  Taisuke Tomita
- Organizer
  The Notch Meeting
- Place of Presentation
  Athens, Greece
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Proteolytic processing of neuroligin 1 modulates its spinogenic function2011
- Author(s)
  Kunimichi Suzuki, Yukari Hayashi, Soichiro Nakahara, Ryuta Koyama, Norio Matsuki, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  Neuroscience 2011
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Functional analyses of sft-4 in the C.elegans Notch pathway2011
- Author(s)
  石渡智之、一色隼人、桑原知樹、諸橋雄一、三谷昌平、富田泰輔、岩坪威
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] PICALM regulates the endocytosis of γ-secretase2011
- Author(s)
  Kunihiko Kanatsu, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  第6回日本Notch研究会
- Place of Presentation
  野田
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] γセクレターゼモジュレーターGSM-1のアミロイドペプチド切断調節機構の解析2011
- Author(s)
  大木優、肥後拓也、島田尚明、大沢智子、福山透、横島聡、富田泰輔、岩坪威
- Organizer
  第30回日本認知症学会学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Identification and functional analysis of a genetic regulator for the trafficking of γ-secretase substrate2011
- Author(s)
  Hayato Isshiki, Yuta Yamashita, Tomoyuki Ishiwata, Yuichi Morohashi, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  第6回日本Notch研究会
- Place of Presentation
  野田
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] The α-helical structure of the hydrophilic loopl of presenilin 1 contributes to the formation of the substrate binding site2011
- Author(s)
  Taisuke Tomita, Shizuka, Takagi, Takeshi Iwatsubo
- Organizer
  Gordon Research Conference on Regulated Proteolysis of Cell Surface Proteins
- Place of Presentation
  Davidson, USA
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] The monoclonal antibody targeting the juxtamembrane region of TMD1 of Presenilin 1 decreases the γ-secretase activity2011
- Author(s)
  Shizuka Takagi, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  Gordon Research Conference on Regulated Proteolysis of Cell Surface Proteins
- Place of Presentation
  Davidson, USA
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Functional analysis of a novel domain modulating γ-secretase-mediated cleavage within amyloid precursor protein2011
- Author(s)
  Tomoki Sasaki, Nobumasa Takasugi, Satoko Osawa, Taisuke Tomita, Takeshi Iwatsubo
- Organizer
  Gordon Research Conference on Regulated Proteolysis of Cell Surface Proteins
- Place of Presentation
  Davidson, USA
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Alzheimer drug mechanisms2010
- Author(s)
  Taisuke Tomita
- Organizer
  2010 FIP Pharmaceutical Science World Congress (PSWC)/AAPS
- Place of Presentation
  New Orleans, USA
- Year and Date
  2010-11-18
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] γセクレターゼモジュレーターGSM-1はプレセニリンN末端断片を標的とする2010
- Author(s)
  富田泰輔
- Organizer
  第29回日本認知症学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure and function relationship analysis of γ-secretase modulator GSM-1.2010
- Author(s)
  Taisuke Tomita
- Organizer
  Society for Neuroscience 40th Annual Meeting.
- Place of Presentation
  Chicago, USA
- Year and Date
  2010-11-14
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure and function relationships of γ-secretase complex.2010
- Author(s)
  富田泰輔
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会/BMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] セクレターゼ阻害薬スタディグループ「次世代の対認知症戦略-診断から予防まで-」2010
- Author(s)
  富田泰輔
- Organizer
  第20回日本臨床精神神経薬理学会・第40回日本神経精神薬理学会合同年会
- Place of Presentation
  仙台
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Alzheimer Drug Mechanisms2010
- Author(s)
  Tomita T
- Organizer
  2010 FIP Pharmaceutical Science World Congress(PSWC)/AAPS
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2010-09-18
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] 化合物を基点としたケミカルバイオロジーによるアルツハイマー病治療薬開発2010
- Author(s)
  富田泰輔
- Organizer
  平成22年度包括型脳科学研究推進支援ネットワーク夏のワークショップ
- Place of Presentation
  札幌
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Molecular mechanism of action ofγ-secretase in hibitors and modulators2010
- Author(s)
  Tomita T
- Organizer
  AAICAD2010
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Molecular mechanism of action of γ-secretase inhibitors and modulators.2010
- Author(s)
  Taisuke Tomita
- Organizer
  AAICAD2010
- Place of Presentation
  Honolulu, USA
- Year and Date
  2010-07-12
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Helical beta-peptide foldamers specifically inhibit the gamma-secretase activity2009
- Author(s)
  富田泰輔
- Organizer
  Society for Neuroscience 39th Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] Helical beta-peptide foldamers specifically inhibit the gamma-secretase activity.2009
- Author(s)
  富田泰輔
- Organizer
  Society for Neuroscience 39th Annual Meeting
- Place of Presentation
  Chicago, USA
- Year and Date
  2009-10-18
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure and function relationship of the gamma-secretase toward development of treatment of Alzheimer's disease.2009
- Author(s)
  富田泰輔
- Organizer
  International Proteolysis Society 2009
- Place of Presentation
  Gold Coast, Australia
- Year and Date
  2009-10-28
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Functional analysis of genetic modulators for the gamma-secretase activity2009
- Author(s)
  富田泰輔
- Organizer
  32nd Annual meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] アルツハイマー病治療薬開発を目指したγセクレターゼの構造活性相関2009
- Author(s)
  富田泰輔
- Organizer
  日本ヒトプロテオーム機構第7回大会
- Place of Presentation
  東京
- Year and Date
  2009-07-26
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Functional analysis genetic modulators for gamma-secretase activity(GAMMOs)2009
- Author(s)
  富田泰輔
- Organizer
  第4回 Notch 研究会
- Place of Presentation
  三島
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] 膜内配列切断酵素γセクレターゼの構造活性相関解析2009
- Author(s)
  富田泰輔
- Organizer
  タンパク質研究所セミナー
- Place of Presentation
  大阪
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure and function relationship of the γ-secretase toward development of treatment of Alzheimer's disease2009
- Author(s)
  Tomita T
- Organizer
  International Proteolysis Society 2009
- Place of Presentation
  Glod Coast, Australia
- Year and Date
  2009-10-28
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Structure and function relationship of theγ-secretase towarddevelopment of treatment of Alzheimer disease2009
- Author(s)
  Tomita T
- Organizer
  International Proteolysis Society 2009
- Place of Presentation
  Gold Coast, Australia
- Year and Date
  2009-10-28
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Single chain variable fragment against Nicastrin inhibits the gamma-secretase activity.2009
- Author(s)
  富田泰輔
- Organizer
  International Conference on Alzheimer's disease 2009
- Place of Presentation
  Vienna, Austria
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Single chain variable fragment against Nicastrin inhibits the gamma-secretase activity2009
- Author(s)
  Tomita T
- Organizer
  International Conference on Alzheimer's disease 2009
- Place of Presentation
  Vienna, Austria
- Year and Date
  2009-07-15
- Data Source
  KAKENHI-PUBLICLY-21025004
[Presentation] Functional analysis of genetic modulators for the gamma-secretase activity.2009
- Author(s)
  富田泰輔
- Organizer
  32nd Annual meeting of the Molecular Biology Society of Japan
- Place of Presentation
  Yokohama
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] γセクレターゼ活性制御によるアルツハイマー病治療2009
- Author(s)
  富田泰輔
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Identification and analysis of a substrate-specific genetic modulator for gamma-secretase activity2009
- Author(s)
  富田泰輔
- Organizer
  Notch Meeting
- Place of Presentation
  Athens, Greece
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] Functional analysis genetic modulators for gamma-secretase activity (GAMMOs)2009
- Author(s)
  富田泰輔
- Organizer
  第4回Notch研究会
- Place of Presentation
  三島
- Year and Date
  2009-07-30
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] γセクレターゼ活性制御によるアルツハイマー病治療2009
- Author(s)
  富田泰輔
- Organizer
  第50回日本神経学会総会
- Place of Presentation
  仙台
- Year and Date
  2009-05-21
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] Identification and analysis of a substrate-specific genetic modulator for gamma-secretase activity.2009
- Author(s)
  富田泰輔
- Organizer
  Notch Meeting
- Place of Presentation
  Athens, Greece
- Year and Date
  2009-09-29
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Transmembrane domain 1 of presenilin 1 contributes to the formation of the catalytic pore of gamma-secretase2008
- Author(s)
  Takagi S, Sato C, Tomita T, Iwatsubo T
- Organizer
  International Conference on Alzheimer's disease 2008
- Place of Presentation
  シカゴ、米国
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] アルツハイマー病治療を目指したγ-セクレターゼの構造活性相関の理解2008
- Author(s)
  富田泰輔
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] Identification and analysis of a substrate-specific genetic modulator for gammasecretase activity2008
- Author(s)
  Isshiki H, Takasugi N, Suzuki K, Tomita T. Iwatsubo T
- Organizer
  Society for Neuroscience 38th Annual Meeting
- Place of Presentation
  ワシントンDC、米国
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] C-terminal PAL motif of Presenilin 1 comprises the subsite of gamma-secretase within the catalytic pore2008
- Author(s)
  Tomita T, Sato C, Takagi S, Iwatsubo T
- Organizer
  International Conference on Alzheimer's disease 2008
- Place of Presentation
  シカゴ、米国
- Data Source
  KAKENHI-PROJECT-19044009
[Presentation] Both the N and C-terminal fragments of Presenilin 1 participate in the formation of the catalytic pore in gamma-secretase2008
- Author(s)
  Tomita T, Sato C, Takagi S, Iwatsubo T
- Organizer
  Society for Neuroscience 38th Annual Meeting
- Place of Presentation
  ワシントンDC、米国
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] 膜内でタンパクがどのように加水分解されるのか : 膜内配列切断プロテアーゼの構造2008
- Author(s)
  富田泰輔
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山
- Year and Date
  2008-09-13
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] The functional roles of transmembrane domains of presenilin 1 in the formation of active gamma-secretase complex2008
- Author(s)
  Watanabe N, Tomita T, Imiatsubo T
- Organizer
  International Conference on Alzheimer's disease 2008
- Place of Presentation
  シカゴ、米国
- Data Source
  KAKENHI-PROJECT-19044009
[Presentation] Functional antibody strategies for the regulation of γ-secretase activity.2008
- Author(s)
  Tomita T
- Organizer
  Keystone Meeting
- Place of Presentation
  Keystone
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19044009
[Presentation] 膜蛋白の膜蛋白による膜蛋白のための膜内配列切断2008
- Author(s)
  富田泰輔
- Organizer
  第60回日本細胞生物学会
- Place of Presentation
  横浜
- Year and Date
  2008-06-30
- Data Source
  KAKENHI-PROJECT-19044009
[Presentation] Fuldentification and analysis of a substratespecific genetic modulator for gammasecretase activity2008
- Author(s)
  Isshiki H, Takasugi N, Suzuki K, Tomita T, Iwatsubo T
- Organizer
  The 15th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] Functional antibody strategies for the regulation of gamma-secretase activity2008
- Author(s)
  Hayashi I, Takatori S, Iwanari H, Kodama T, Hamakubo T, Iwatsubo T, Tomita T
- Organizer
  The 15th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19044009
[Presentation] γセクレターゼモジュレーターによるAB産生制御機構2008
- Author(s)
  富田泰輔
- Organizer
  第27回日本認知症学会
- Place of Presentation
  前橋
- Year and Date
  2008-10-11
- Data Source
  KAKENHI-PROJECT-20023007
[Presentation] Structure and function of γ-secretase complex.2007
- Author(s)
  Tomita T
- Organizer
  Neuro2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-09-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Targeting the structure and function of γ-secretase for the treatment of Alzheimer's disease.2007
- Author(s)
  Tomita T
- Organizer
  BMB2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-12-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] γ-Secretase; intramembrane proteolysis for signaling and neurodegeneration.2007
- Author(s)
  Tomita T
- Organizer
  1st Dependence Receptor Meeting and 10th Neuroblastoma Research Meeting
- Place of Presentation
  Tokyo
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] At the frontline of Alzheimer's disease treatment : γ-secretase inhibitor/modulator mechanism.2007
- Author(s)
  Tomita T
- Organizer
  5th International Symposium on Receptor mechanisms, Signal transduction and Drug effects
- Place of Presentation
  Shizuoka
- Year and Date
  2007-05-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] γ-Secretase; intramembrane proteolysis for signaling and neurodeaeneration.2007
- Author(s)
  Tomita T
- Organizer
  1^<st> Dependence Receptor Meeting and 10^<th> Neuroblastoma Research Meeting
- Place of Presentation
  Tokyo
- Year and Date
  2007-10-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Neutralization of the γ-secretase activity by antibody against extracellular domain of nicastrin.2007
- Author(s)
  Tomita T
- Organizer
  The Notch Meeting
- Place of Presentation
  Athens
- Year and Date
  2007-09-25
- Data Source
  KAKENHI-PROJECT-19044009
[Presentation] Structure and function of y-secretase complex.2007
- Author(s)
  Tomita T
- Organizer
  Neuro 2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-09-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Neutralization of the γ-secretase activity by antibody against extracellular domain of nicastrin.2007
- Author(s)
  Tomita T
- Organizer
  Society for Neuroscience 37th Annual Meeting
- Place of Presentation
  San Diego
- Year and Date
  2007-11-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Neutralization of the γ-secretase activity by antibody against extracellular domain of nicastrin.2007
- Author(s)
  Tomita T
- Organizer
  The Notch Meeting
- Place of Presentation
  Athens
- Year and Date
  2007-09-25
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Neutralization of the γ-secretase activity by antibody against extracellular domain of nicastrin.2007
- Author(s)
  Tomita T
- Organizer
  Society for Neuroscience 37th Annual Meeting
- Place of Presentation
  San Diego
- Year and Date
  2007-11-06
- Data Source
  KAKENHI-PROJECT-19044009
[Presentation] Targeting the structure and function of γ-secretase for the treatment of Alzheimer's disease.2007
- Author(s)
  Tomita T
- Organizer
  BMB2007
- Place of Presentation
  横浜
- Year and Date
  2007-12-14
- Data Source
  KAKENHI-PROJECT-19679001
[Presentation] Different actions of small compounds against γ-secretase complex define the specificity of γ-secretase inhibitor.2006
- Author(s)
  Tomita T
- Organizer
  Keystone Symposia
- Place of Presentation
  Breckenridge
- Year and Date
  2006-02-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Different actions of dipeptidic compounds on presenilins define the enzyme specificity of γ-secretase inhibitor.2006
- Author(s)
  Tomita T
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid
- Year and Date
  2006-07-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Screening for genes and small molecules that modulate γ-secretase.2006
- Author(s)
  Tomita T
- Organizer
  The 6th annual meeting of The International College of Geriatric Psychoneuropharmacology
- Place of Presentation
  Hiroshima
- Year and Date
  2006-10-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] γ-Secretase: molecular target for Alzheimer's disease treatment.2006
- Author(s)
  Tomita T
- Organizer
  AACL-Nagasaki Symposium ASIAN AGING 2006
- Place of Presentation
  Nagasaki
- Year and Date
  2006-06-18
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] γ-Secretase as a therapeutic target for Alzheimer's disease.2006
- Author(s)
  Tomita T
- Organizer
  Japanese-German Frontiers of Science (JGFoS 2006)
- Place of Presentation
  Heidelberg
- Year and Date
  2006-11-05
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Screening for genes and small molecules that modulate γ-secretase.2006
- Author(s)
  Tomita T
- Organizer
  The 6th annual meeting of The International Colleae of Geriatric Psychoneuropharmacology
- Place of Presentation
  Hiroshima
- Year and Date
  2006-10-07
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] Different actions of dipeptidic compounds on presenilins define the enzyme specificitv of γ-secretase inhibitor.2006
- Author(s)
  Tomita T
- Organizer
  The 10th International Conference on Alzheimer's Disease and Related Disorders
- Place of Presentation
  Madrid
- Year and Date
  2006-07-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] γ-Secretase : molecular target for Alzheimer's disease treatment.2006
- Author(s)
  Tomita T
- Organizer
  AACL-Nagasaki Symposium ASIANAGING 2006
- Place of Presentation
  Nagasaki
- Year and Date
  2006-06-18
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] The roles of conserved hydrophilic residues in transmembrane domains of Aph-1 in the formation and function of γ-secretase complex.2005
- Author(s)
  Tomita T
- Organizer
  Society for Neuroscience 35th Annual Meeting
- Place of Presentation
  Washington DC
- Year and Date
  2005-11-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390015
[Presentation] 先制医療を目指したアルツハイマー病治療薬開発に向けて
- Author(s)
  富田泰輔
- Organizer
  第46回日本薬剤師会学術大会
- Place of Presentation
  大阪府、大阪市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Physiological and pathological roles of proteolytic processing of autism-related neuroligin proteins.
- Author(s)
  Taisuke Tomita
- Organizer
  New Frontier of Molecular Neuropathology 2014
- Place of Presentation
  東京都、文京区
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] 遺伝学的アルツハイマー病リスク因子がもたらす分子病態の解明
- Author(s)
  富田泰輔
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本県、熊本市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] 先制医療の開発に向けたアルツハイマー病の分子病態解明
- Author(s)
  富田泰輔
- Organizer
  第57回日本薬学会関東支部大会
- Place of Presentation
  東京都、板橋区
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] アルツハイマー病の分子病態解明：先制医療の開発に向けて
- Author(s)
  富田泰輔
- Organizer
  東京大学生命科学シンポジウム
- Place of Presentation
  東京都、文京区
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] Structure and function relationship of intramembrane-cleaving gamma-secretase.
- Author(s)
  Taisuke Tomita
- Organizer
  第86回日本生化学会
- Place of Presentation
  神奈川県、横浜市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] シナプス接着分子Neuroliginの神経活動依存性プロセシング
- Author(s)
  富田泰輔
- Organizer
  平成25年度生理学研究所研究会「シナプス恒常性維持の分子基盤とその破綻」
- Place of Presentation
  愛知県、岡崎市
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511
[Presentation] アルツハイマー病先制医療の開発に向けて：現状と展望
- Author(s)
  富田泰輔
- Organizer
  星薬科大学認定薬剤師研究　薬剤師生涯学習・講演会シリーズ
- Place of Presentation
  東京都、品川区
- Invited
- Data Source
  KAKENHI-PUBLICLY-24111511

1. IWATSUBO Takeshi (50223409)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. 堀由起子 (80610683)

# of Collaborated Projects: 4 results

# of Collaborated Products: 60 results
3. Hasegawa Masato (10251232)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 高鳥翔 (80624361)

# of Collaborated Projects: 2 results

# of Collaborated Products: 35 results
5. Kimura Minoru (40118451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Tanji Jun (10001885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Takada Masahiko (00236233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Nakamura Katsuki (70243110)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. Ohtsuka Toshihisa (40401806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Aoki Shigeki (80222470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. Takao Hidemasa (10444093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. Shimoji Keigo (20348931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Goto Masami (30375844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. Yoshiura Takashi (40322747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. Nakata Yasuhiro (40362066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. Abe Osamu (50302716)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. Masumoto Tomohiko (60302717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Tokumaru Aya (60507391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. Matsumura Akira (90241819)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Kirino Eiji (90276460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. Terada Hitoshi (90277319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Sato Noriko (10322017)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. Kasai Kiyoto (80322056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. Hashimoto Ryota (10370983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. Niwa Shin-ichi (30110703)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Kato Tadafumi (30214381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. Suzuki Michio (40236013)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. Shuji Iritani (60191904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. Nemoto Kiyotaka (80550152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. Tomita Hiroaki (90295064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
31. Murayama Shigeo (50183653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
32. Akatsu Hiroyasu (00399734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. Takao Masaki (50245487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. Saito Yuko (60344066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. Bito Haruhiko (00291964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. Yoshimura Yumiko (10291907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. Matsuzaki Masanori (50353438)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. Furuta Toshiaki (90231571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. Okado Haruo (60221842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
40. Saito Izumu (70158913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. Kaibuchi Kozo (00169377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. Aiba Atsu (20271116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
43. Shiina Nobuyuki (30332175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. Igarashi Michihiro (50193173)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. Tomoki Nishioka (70435105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. Watanabe Masahiko (70210945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. Koike Masato (80347210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. Sakagami Hiroyuki (90261528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. Shigemoto Ryuichi (20221294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. Fukazawa Yugo (60343745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. Sakimura Kenji (40162325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. Mori Hisashi (00239617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. Mishina Masayoshi (80144351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. Kobayashi Kazuto (90211903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
55. Yanagawa Yuchio (90202366)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
56. Uemura Tadashi (80213396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
57. Ishihara Takeshi (10249948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
58. Nose Akinao (30260037)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
59. Iino Yuichi (40192471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
60. Miyakawa Tsuyoshi (10301780)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
61. Takao Keizo (80420397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
62. Mushiake Hajime (80219849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
63. Katayama Norihiro (20282030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
64. Tanaka Tetsu (40417382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
65. Inoue Kazuhide (80124379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
66. Okabe Shigeo (60204012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
67. Kano Masanobu (40185963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
68. Fujiyama Fumino (20244022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
69. Isa Tadashi (20212805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
70. Kageyama Ryoichiro (80224369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
71. Fujita Ichiro (60181351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
72. Yoshida Akira (70257187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
73. Nishikawa Toru (00198441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
74. Nukina Nobuyuki (10134595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
75. Fukai Tomoki (40218871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
76. Yamamori Tetsuo (80260206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
77. Okazawa Hitoshi (50261996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
78. Tanaka Keiji (00221391)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
79. Kakigi Ryusuke (10145196)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
80. Tsuda Ichiro (10207384)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
81. Kitazawa Shigeru (00251231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
82. Doya Kenji (80188846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
83. Takahashi Ryosuke (90216771)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
84. Ikenaka Kazuhiro (00144527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
85. Sobue Gen (20148315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
86. Hasegawa Toshikazu (30172894)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
87. Ota Jun (50233127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
88. Saitoe Minoru (50261839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
89. Kadomatsu Kenji (80204519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
90. Kida Satoshi (80301547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
91. Manabe Toshiya (70251212)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
92. Iwata Atsushi (40401038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
93. Murakami Ikuya (60396166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
94. Tsutsui Ken-ichiro (90396466)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
95. Hanakawa Takashi (30359830)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
96. Hirai Hirokazu (70291086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
97. Mima Tatsuya (20324618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
98. Isomura Yoshikazu (00415077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
99. Samejima Kazuyuki (30395131)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
100. Hoshi Eiji (50407681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
101. Miyata Mariko (70281631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
102. Yuzaki Michisuke (40365226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
103. Tanaka Masaki (90301887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
104. Fukata Masaki (00335027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
105. Suzuki Kyoko (20271934)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
106. Kuba Hiroshi (10362469)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
107. Masu Masayuki (20243032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
108. Kinoshita Makoto (30273460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
109. Sugihara Izumi (60187656)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
110. Shirane Michiko (90398082)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
111. Yamamoto Nobuhiko (00191429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
112. Nishijo Hisao (00189284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
113. Nambu Atsushi (80180553)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
114. Takumi Toru (00222092)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
115. Yamashita Toshihide (10301269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
116. Sakurai Takeshi (60251055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
117. Tamamaki Nobuaki (20155253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
118. Hata Yoshio (40212146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
119. Harada Akihiro (40251441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
120. Ozaki Norio (40281480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
121. Sakai Katsuyuki (70376416)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
122. Kubo Yoshihiro (80211887)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
123. Nakazawa Takanobu (00447335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
124. Tanaka Kenji (30329700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
125. Takei Nobuyuki (70221372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
126. Hitoshi Seiji (70300895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
127. Takahiroa. Kato (70546465)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
128. Kato Fusao (20169519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
129. Shirao Tomoaki (20171043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
130. Taira Masato (50179397)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
131. Okano Hideyuki (60160694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
132. Sekino Yuko (70138866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
133. Okamoto Yasumasa (70314763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
134. KOMATSU Hidehiko (00153669)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
135. Miyata Takaki (70311751)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
136. Takahashi Yoshiko (10183857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
137. Nishida Shinya (20396162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
138. Tominaga Makoto (90260041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
139. TAKASUGI NOBUMASA (60436590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
140. 寺田一志 (90227520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
141. 伊藤弦太 (10431892)

# of Collaborated Projects: 1 results

# of Collaborated Products: 34 results
142. 樽谷愛理 (10815187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
143. 木村妙子 (60748820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
144. 金井求 (20243264)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
145. マラフスカカタジナ・ヨアンナ (90986374)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
146. NISHIZAWA Yukio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
147. ZOU Kun

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
148. SATO Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
149. FUTAI Eugene

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
150. ISOO Noriko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
151. 林俊宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
152. 宮下哲典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tomita Taisuke 富田 泰輔

TOMITA Taisuke 富田 泰輔

Research Projects

Research Products

Co-Researchers

中枢神経系プロテイノパチー発症機構の統合的解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of TDP-43 dynamics regulated by intracellular temperaturePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the role of autophagy in photo-oxygenated amyloid degradationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Molecular Pathogenesis Leading to Abnormal Synapse Formation in the Pathogenesis of AutismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Cellular Pathogenesis as a Key Mechanism for Neurodegenerative Processes in the Pathogenesis of DementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Spatial and temporal control of intracellular aggregates by photo-oxygenation catalystPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of genetic regulators for intracellular aggregation by genome-wide CRISPR screeningPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of preemptive medicine based on the molecular mechanism of risk factors for Alzheimer diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

炎症反応に呼応する神経外環境因子によるアミロイドβタンパク代謝制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of molecular mechanisms for synaptic homeostasis regulated by monoaminergic neurotransmittersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Simultaneous control of the production and degradation of Amyloid be-ta by Sphingosine kinase/sphingosine-1-phosphate signaling

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経炎症反応によって制御される脳内アミロイド代謝システムの分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Alterations of proteolytic processing of synaptic adhesion molecules in Alzheimer diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Tomita Taisuke 富田泰輔

TOMITA Taisuke 富田泰輔