NISHIZAWA Tsutomu 西澤勉

Researcher Number	30306112
Other IDs
Affiliation (Current)	2022: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2014: 自治医科大学, 医学部, 非常勤講師 2012: 自治医科大学, 医学部, 講師 2002 – 2005: Jichi Medical School, Department of Infection and Immunity, Assistant Professor, 医学部, 講師 2000 – 2002: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Virology Except Principal Investigator Virology / Virology
Keywords	Principal Investigator Western blotting / TTウイルス / 遺伝子発現 / 抗原抗体測定系 / バキュロウイルス / 抗原、抗体 / 遺伝子型 / 抗体 / TT virus / gene expression / antigen and antibody assay system / Baculovirus … More Except Principal Investigator … More TTV / PCR / E型肝炎ウイルス / 遺伝子型 / 放出 / TTウイルス / 分子系統樹 / TTウイルス(TTV) / selective PCR / E 型肝炎ウイルス / 粒子形成 / MVB 経路 / Tsg101 / Vps4 / エンドソーム輸送 / MVB経路 / ESCRT機構 / エクソソーム / 多胞体 / 出芽 / エクソソーム分泌経路 / エンベロープ / 環状1本鎖DNA / 肝疾患 / 肝外疾患 / 複製中間体 / TTV DNA量 / 特発性肺線維症 / 電子顕微鏡像 / チンパンジー感染実験 / TTV抗体 / DNAウイルス / 超可変領域 / 血清肝炎 / 塩基配列 / TTウイルス抗体 / 遺伝子変異 / TT virus / circular single-stranded DNA / genotype / phylogenetic group / liver disease / extrahepatic disease / トークテノウイルス / 遺伝子グループ / Neighbor-joining法 / Tprque genotype virus / phylogenetic tree / Genetic group / E型肝炎 / 人畜共通感染症 / ELISA法 / IgAクラス抗HEV抗体 / 感染源 / 食感染 / 感染経路 / 劇症肝炎 / 核酸診断法 / IgAクラスHEV抗体 / 輸血感染 / Hepatitis E / Hepatitis E virus / Zoonosis / ELISA / IgA class anti-HEV / Infectious source / Food-borne transmission / Genotype Less

Research on mechanism of hepatitis E virus egress utilizing membrane traffic
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Molecular epidemiological analysis of hepatitis E as a zoonosis and investigation toward its prevention
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
Development of genotyping method for TT virus (TTV) and its application to elucidation of pathogenesis.
- Principal Investigator
  
  OKAMOTO Hiroaki, 真弓忠
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
Gene expression of TT virus and development of its antigen and antibody assay systemsPrincipal Investigator
- Principal Investigator
  
  NISHIZAWA Tsutomu
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical School
Research on genomic characteristics and disease associations of a newly discovered human serum hepatitis virus (TT virus)
- Principal Investigator
  
  MAYUMI Makoto
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL

All 2014 2013 2012 2011 2005 Other

All Journal Article Presentation

[Journal Article] Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains2014
- Author(s)
  Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 180 Pages: 59-69
- DOI
  10.1016/j.virusres.2013.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis2014
- Author(s)
  Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 179 Pages: 102-112
- DOI
  10.1016/j.virusres.2013.10.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.2014
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Archives of Virology
  
  Volume: 159 Pages: 979-991
- DOI
  10.1007/s00705-013-1912-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines.2014
- Author(s)
  Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 185 Pages: 92-102
- DOI
  10.1016/j.virusres.2014.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan2014
- Author(s)
  Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中
- DOI
  10.1111/hepr.12216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.2014
- Author(s)
  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Pages: 2166-2175
- DOI
  10.1099/vir.0.066910-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Frequent detectionand characterization of hepatitis E virusvariants in wild rats (Rattus rattus) inIndonesia.2013
- Author(s)
  Mulyanto
- Journal Title
  
  Arch Virol
  
  Volume: 158 Pages: 87-96
- DOI
  10.1007/s00705-012-1462-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Molucular analysis of hepatitis E virus fromfarm rabbits in Inner Mongolia, China and itssuccessful propagation in A549 andPLC/PRF/5 cells.2012
- Author(s)
  Jirintai S
- Journal Title
  
  Virus Res
  
  Volume: 170 Pages: 126-137
- DOI
  10.1016/j.virusres.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] A549 and PLC/PRF/5cells can support the efficient propagation ofswine and wild boar hepatitis E virus (HEV)strains: demonstration of HEV infectivity ofporcine liver sold as food2012
- Author(s)
  Takahashi H
- Journal Title
  
  Arch Virol
  
  Volume: 157 Pages: 235-246
- DOI
  10.1007/s00705-011-1153-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Tumorsusceptibility gene 101 and vacuolar proteinsorting pathway are required for release ofhepatitis E virions2011
- Author(s)
  Nagashima S
- Journal Title
  
  J Gen Virol
  
  Volume: 92 Pages: 2838-2848
- DOI
  10.1099/vir.0.035378-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan.2005
- Author(s)
  Nishizawa T.
- Journal Title
  
  Journal of General Virology 86・12
  
  Pages: 3321-3326
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390137
[Journal Article] Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan.2005
- Author(s)
  Nishizawa T, et al.
- Journal Title
  
  J Gen Virol 86
  
  Pages: 3321-3326
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390137
[Presentation] 細胞内膜輸送系を利用したE型肝炎ウイルスの放出機構の解析2013
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、小林富成、西澤勉、岡本宏明
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860343
[Presentation] 培養細胞から放出された E 型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、西澤勉、小林富成、岡本宏明
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H
- Organizer
  15thInternational Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Organizer
  15th International Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] E型肝炎ウイルスの細胞侵入機構の解析
- Author(s)
  長嶋茂雄、吉林台、小林富成、唐吉思、高橋雅春、西澤勉、岡本宏明
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25860343

1. OKAMOTO Hiroaki (30177092)

# of Collaborated Projects: 6 results

# of Collaborated Products: 15 results
2. TAKAHASHI Masaharu (70326841)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
3. NAGASHIMA Shigeo (60433116)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. KOBAYASHI Tominari (00634164)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
5. MAYUMI Makoto (00049016)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YASUDA Jiro (10282518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. YASHIRO Takashi (80119859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KOUKI Tom (70350436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

NISHIZAWA Tsutomu 西澤 勉

Research Projects

Research Products

Co-Researchers

Research on mechanism of hepatitis E virus egress utilizing membrane traffic

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular epidemiological analysis of hepatitis E as a zoonosis and investigation toward its prevention

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of genotyping method for TT virus (TTV) and its application to elucidation of pathogenesis.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene expression of TT virus and development of its antigen and antibody assay systemsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on genomic characteristics and disease associations of a newly discovered human serum hepatitis virus (TT virus)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequent detectionand characterization of hepatitis E virusvariants in wild rats (Rattus rattus) inIndonesia.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molucular analysis of hepatitis E virus fromfarm rabbits in Inner Mongolia, China and itssuccessful propagation in A549 andPLC/PRF/5 cells.2012

Author(s)

Journal Title

DOI

Data Source

NISHIZAWA Tsutomu 西澤勉