OKAMOTO Hiroaki 岡本宏明

Researcher Number	30177092
Other IDs
Affiliation *help	2014 : 自治医科大学, 医学部, 教授 2010 – 2012 : Jichi Medical University, 医学部, 教授 2007 – 2008 : 自治医大, 医学部, 教授 2007 – 2008 : Jichi Medical University, 医学部, 教授 2008 : Jichi Medical University, 医学部・感染免疫学講座ウイルス学部門, 教授 … More
Review Section/Research Field	Principal Investigator Virology / Virology Except Principal Investigator Virology / Virology / Digestive surgery / Legal medicine
Keywords	Principal Investigator 遺伝子型 / E型肝炎ウイルス / TTV / 劇症肝炎 / RT-PCR / PCR / tandem dimer / 放出機構 / mRNA / 感染性cDNAクローン … More Except Principal Investigator E型肝炎ウイルス / PCR / TTV / 放出 / TTウイルス抗体 / 糖鎖構造 / TTウイルス / 遺伝子型 / Liver transplantation / Monoclonal抗体 / 非特異的免疫抑制剤 / extrahepatic disease / ハイドロダイナミクス法 / 超可変領域(HVR) / FK506 / 分子系統樹 / ABO group / MN式血液型 / E 型肝炎ウイルス / エンベロープ / 肝移植 / Non-specific immunosuppressant / 人獣血鑑別 / 物体検査 / Lewis group / 血液型検査 / phylogenetic group / KF506 / 細胞融合法 / 非特異的免没抑制剤 / エクソソーム / チンパンジー感染実験 / Viral hepatitis / Glycophorin / 血液型判定用抗体 / Blood grouping / Glycolipid / Monoclonal antibody / 超可変領域 / 塩基配列 / MN group / 電子顕微鏡像 / 糖鎖抗原 / ABO式血液型 / ラット / predisposition / 血液型判定用試薬 / エンドソーム輸送 / ウイルス性肝炎 / 赤血球膜抗原 / Tsg101 / 肝外疾患 / 血痕検査 / liver disease / ルイス式血液型 / 肝疾患 / 遺伝子銃 / genotype / Glycophorin・Glycolipid / DNAウイルス / Lewis式血液型 / DNAワクチン / 肝発がん / 特発性肺線維症 / 血清肝炎 / 遺伝子変異 / TT virus / 細胞内局在性 / エクソソーム分泌経路 / 多胞体 / 粒子形成 / 種属鑑別 / X遺伝子 / TTウイルス(TTV) / 環状1本鎖DNA / Hydrodynamic DNA injection / 癌抑制遺伝子p53 / ESCRT機構 / DNA vaccine / Vps4 / TTV DNA量 / Gene gun / HCV遺伝子型 / MVB 経路 / C型肝炎ウイルス(HCV) / B型肝炎ウイルス(HBV) / circular single-stranded DNA / TTV抗体 / 出芽 / 複製中間体 / 血液型物質 / MVB経路 / B型肝炎 / モノクローナル抗体 Less

Research on mechanism of hepatitis E virus egress utilizing membrane traffic
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEVPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Characterization of hepatitis E virus (HEV) particles and analysis of replication mechanism by using a cell culture system for HEVPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Molecular epidemiological analysis of hepatitis E as a zoonosis and investigation toward its preventionPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
Development of genotyping method for TT virus (TTV) and its application to elucidation of pathogenesis.Principal Investigator
- Principal Investigator
  
  OKAMOTO Hiroaki, 真弓忠
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
Analysis of replication and transcription mechanisms in a newly discovered circular, single-stranded DNA virus (TTV)Principal Investigator
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Development for DNA vaccination against viral hepatitis recurrence after the liver transplantation using gene gun
- Principal Investigator
  
  KOBAYASHI Eiji
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Jichi Medical University
Research on genomic characteristics and disease associations of a newly discovered human serum hepatitis virus (TT virus)
- Principal Investigator
  
  MAYUMI Makoto
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
ANALYSIS OF GENOMIC STRUCTURE OF HEPATITIS G VIRUS (GBV-C/HGV) AND DEVELOPMENT OF SENSITIVE DETECTION SYSTEM OF THE VIRAL GENOMEPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
肝炎ウイルスの増殖と肝発がん
- Principal Investigator
  
  小池克郎
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Japanese Foundation For Cancer Research
PURIFICATION OF HEPATITIS C VIRUS PARTICLES AND ANALYSIS OF ITS STRUCTURAL PROTEINSPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
The production of monoclonal antibodies by mouse-mouse hybridoma cell lines and its application against blood grouping of the forensic materials.
- Principal Investigator
  
  IKEMOTO Shigenori
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Legal medicine
- Research Institution
  Jichi Medical School

All 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book

[Book] 症例から学ぶウイルス肝炎の治療戦略2010
- Author(s)
  岡本宏明(共著)
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] High genomic similarity between European type hepatitis E virus subgenotype 3e strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan2014
- Author(s)
  Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
- Journal Title
  
  Hepatology Research
  
  Volume : 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-22390090
[Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 22014
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Archives of Virology
  
  Volume : 159 Pages : 979-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan2014
- Author(s)
  Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Hepatology Research
  
  Volume : 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines2014
- Author(s)
  Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume : 185 Pages : 92-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies2014
- Author(s)
  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H
- Journal Title
  
  Journal of General Virology
  
  Volume : 95 Pages : 2166-2175
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis2014
- Author(s)
  Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume : 179 Pages : 102-112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains2014
- Author(s)
  Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume : 180 Pages : 59-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Features of hepatitis E virus infection in humans and animals in Japan2013
- Author(s)
  Takahashi M, Okamoto H
- Journal Title
  
  Hepatol Res
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Culture systems for hepatitis E virus2013
- Author(s)
  Okamoto H.
- Journal Title
  
  J Gastroenterol
  
  Volume : 48(2) Pages : 147-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013
- Author(s)
  Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H
- Journal Title
  
  Arch Virol
  
  Volume : 158(1) Pages : 87-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] 抗肝炎ウイルス薬(A型肝炎、E型肝炎)2013
- Author(s)
  岡本宏明
- Journal Title
  
  臨床と微生物
  
  Volume : 40 Pages : 57-63
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Culture systems for hepatitis E virus2013
- Author(s)
  Okamoto H
- Journal Title
  
  Journal of Gastroenterology
  
  Volume : 48 Pages : 147-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013
- Author(s)
  Mulyanto
- Journal Title
  
  Archives of Virology
  
  Volume : 158 Pages : 87-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains : demonstration of HEV infectivity of porcine liver sold as food2012
- Author(s)
  Takahashi H
- Journal Title
  
  Archives of Virology
  
  Volume : 157 Pages : 235-246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Res
  
  Volume : 170(1-2) Pages : 126-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Icteric acute hepatitis E with no response of immunoglobulin M class anti-hepatitis E virus antibody2012
- Author(s)
  Takikawa Y, Miyamoto Y, Onodera M, Kuroda H, Kasai K, Miyasaka A, Takahashi M, Okamoto H, Suzuki K
- Journal Title
  
  Hepatol Res
  
  Volume : 42(11) Pages : 1146-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution2012
- Author(s)
  Nakano T, Takahashi K, Pybus OG, Hashimoto N, Kato H, Okano H, Kobayashi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S.
- Journal Title
  
  Liver Int
  
  Volume : 32(4) Pages : 675-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan2012
- Author(s)
  Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H
- Journal Title
  
  Infect Genet Evol
  
  Volume : 12(7) Pages : 1524-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food2012
- Author(s)
  Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H
- Journal Title
  
  Arch Virol
  
  Volume : 157(2) Pages : 235-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] E型肝炎ウイルス感染の現状と対策2012
- Author(s)
  岡本宏明
- Journal Title
  
  血液事業
  
  Volume : 35 Pages : 228-229
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] E型肝炎ウイルス培養系2012
- Author(s)
  岡本宏明
- Journal Title
  
  化学療法の領域
  
  Volume : 28 Pages : 114-123
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] E型肝炎の現状と今後の戦略2012
- Author(s)
  岡本宏明
- Journal Title
  
  日本医事新報
  
  Volume : 4621 Pages : 71-77
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  Jirintai S
- Journal Title
  
  Virus Research
  
  Volume : 170 Pages : 126-137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Hepatitis E virus cell culture models2011
- Author(s)
  Okamoto H
- Journal Title
  
  Virus Res
  
  Volume : 161(1) Pages : 65-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood2011
- Author(s)
  Okamoto H
- Journal Title
  
  Rev Med Virol
  
  Volume : 21(1) Pages : 18-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Journal Title
  
  J Gen Virol
  
  Volume : 92(Pt 12) Pages : 2838-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Hepatitis E virus cell culture models2011
- Author(s)
  Okamoto H
- Journal Title
  
  Virus Research
  
  Volume : 161 Pages : 65-77
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] E型肝炎ウイルスのウイルス学的特徴2011
- Author(s)
  岡本宏明
- Journal Title
  
  日本臨床
  
  Volume : 69 Pages : 579-587
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume : 92(Pt 2) Pages : 269-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype2011
- Author(s)
  Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume : 92(Pt 4) Pages : 902-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood.2011
- Author(s)
  Okamoto H
- Journal Title
  
  Reviews in Medical Virology
  
  Volume : 21 Pages : 18-31
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes2011
- Author(s)
  Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H.
- Journal Title
  
  Arch Virol
  
  Volume : 156(8) Pages : 1345-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions2011
- Author(s)
  Nagashima S
- Journal Title
  
  Journal of General Virology
  
  Volume : 92 Pages : 2838-2848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] E型肝炎の現況2011
- Author(s)
  岡本宏明
- Journal Title
  
  綜合臨牀
  
  Volume : 60 Pages : 95-101
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia2010
- Author(s)
  Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H
- Journal Title
  
  China. Arch Virol
  
  Volume : 155(8) Pages : 1217-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A nationwide survey of hepatitis E virus infection in the general population of Japan2010
- Author(s)
  Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H.
- Journal Title
  
  J Med Virol
  
  Volume : 82(2) Pages : 271-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation2010
- Author(s)
  Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H.
- Journal Title
  
  J Clin Microbiol
  
  Volume : 48(4) Pages : 1112-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] E型肝炎をめぐって-診断法と感染培養系の確立と基礎・臨床への応用-2010
- Author(s)
  岡本宏明
- Journal Title
  
  Minophagen Medical Review
  
  Volume : 55 Pages : 207-218
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] E型肝炎ウイルス感染2010
- Author(s)
  岡本宏明
- Journal Title
  
  治療学
  
  Volume : 44 Pages : 974-977
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] E型肝炎ウイルスの感染培養系2010
- Author(s)
  岡本宏明
- Journal Title
  
  ウイルス
  
  Volume : 60 Pages : 93-104
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] ORF3 protein of hepatitis E virus is essential for virion release from infected cells.2009
- Author(s)
  Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  J Gen Virol doi:10.1099/Vir.0.010561-0(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells.2009
- Author(s)
  Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  J Gen Virol 90(2)
  
  Pages : 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Development and characterization of a genotype 4 hepatitis E virus cell culture system using the HE-JF5/15F strain recovered from a fulminant hepatitis patient.2009
- Author(s)
  Tanaka T, Takahashi M, Takahashi H, Ichiyama K, Hoshino Y, Nagashima S, Mizuo H, Okamoto H
- Journal Title
  
  J Clin Microbiol 47
  
  Pages : 1906-1910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan.2009
- Author(s)
  Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T
- Journal Title
  
  J Gastroenterol 44
  
  Pages : 329-337
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.2008
- Author(s)
  Takahashi M, Yamada K, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  Arch Virol 153
  
  Pages : 1703-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture.2008
- Author(s)
  Lorenzo FR, Tanaka T, Takahashi H, Ichiyama K, Hoshino Y, Yamada K, Inoue J, Takahashi M, Okamoto H
- Journal Title
  
  Virus Res 137
  
  Pages : 86-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neutralizing activity in a cell culture system.2008
- Author(s)
  Takahashi M, Hoshino Y, Tanaka T, Takahashi H, Nishizawa T, Okamoto H
- Journal Title
  
  Arch Virol 153
  
  Pages : 657-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm pigs in Bali, Indonesia.2007
- Author(s)
  Wibawa IDN, Suryadarma IGA, Mulyanto, Tsuda F, Matsumoto Y, Ninomiya M, Takahashi M, Okamoto H
- Journal Title
  
  J Med Virol 79
  
  Pages : 1138-1146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Genetic variability and evolution of hepatitis E virus.2007
- Author(s)
  Okamoto H.
- Journal Title
  
  Virus Res 127(2)
  
  Pages : 216-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan.2007
- Author(s)
  Gotanda Y, Iwata A, Ohnuma H, Yoshikawa A, Mizoguchi H, Endo K, Takahashi M, Okamoto H
- Journal Title
  
  J Med Virol 79
  
  Pages : 734-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia.2007
- Author(s)
  Lorenzo FR, Tsatsralt-Od B, Ganbat S, Takahashi M, Okamoto H
- Journal Title
  
  J Med Virol 79
  
  Pages : 1128-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006.2007
- Author(s)
  Fukuda S, Ishikawa M, Ochiai N, Suzuki Y, Sunaga J, Shinohara N, Nozawa K, Tsuda F, Takahashi M, Okamoto H
- Journal Title
  
  Arch Virol 152
  
  Pages : 1623-1635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system.2007
- Author(s)
  Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H
- Journal Title
  
  J Clin Microbiol 45(11)
  
  Pages : 3671-3679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Development and evaluation of an efficient cell-culture system for Hepatitis E virus.2007
- Author(s)
  Tanaka T, Takahashi M, Kusano E, Okamoto H.
- Journal Title
  
  J Gen Virol 88
  
  Pages : 903-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Genetic variability and evolution of hepatitis E virus2007
- Author(s)
  Okamoto H
- Journal Title
  
  Virus Research 127
  
  Pages : 216-228
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] A high genomic similarity between European type hepatitis E virus subgenotype 3e Jirintai S, Jinshan, Tanggis, Manglai 18. strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan
- Author(s)
  Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
- Journal Title
  
  Jinshan, Tanggis, Manglai
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 細胞内膜輸送系を利用したE型肝炎ウイルスの放出機構の解析2013
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、小林富成、西澤勉、岡本宏明
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860343
[Presentation] 特別講演「経口肝炎ウイルス:最近の知見」2012
- Author(s)
  岡本宏明
- Organizer
  第60回日本輸血細胞治療学会総会
- Place of Presentation
  郡山市
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] シンポジウム「E 型肝炎ウイルスについての最近の知見」2012
- Author(s)
  岡本宏明
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪市
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] Culture systems for hepatitis E virus2012
- Author(s)
  Okamoto, H.
- Organizer
  The 3rd International Forum of the 98th General Meeting of the Japanese Society of Gastroenterology
- Place of Presentation
  Tokyo
- Year and Date
  2012-04-21
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 培養細胞から放出された E 型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、西澤勉、小林富成、岡本宏明
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] E型肝炎ウイルスについての最近の知見2012
- Author(s)
  岡本宏明
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪国際会議場(大阪市)
- Invited
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 輸血によるウイルス感染の更なる減少を目指して2012
- Author(s)
  岡本宏明
- Organizer
  第36回日本血液事業学会総会
- Place of Presentation
  仙台国際センター(仙台市)
- Invited
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 経口肝炎ウイルス：最近の知見2012
- Author(s)
  岡本宏明
- Organizer
  第60回日本輸血細胞治療学会総会
- Place of Presentation
  ホテルハマツ(郡山市)
- Invited
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] Tsg101 and vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima, S., Takahashi, M., Jirintai, Tanaka, T., Nishizawa, T., Yasuda J, Okamoto, H
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Organizer
  15th International Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H
- Organizer
  15thInternational Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] E型肝炎ウイルス感染の現状と対策2011
- Author(s)
  岡本宏明
- Organizer
  第35回日本血液事業学会総会
- Place of Presentation
  浦和市
- Year and Date
  2011-10-23
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 肝炎ウイルスと肝炎重症化(劇症化)2010
- Author(s)
  岡本宏明
- Organizer
  第36回日本急性肝不全研究会
- Place of Presentation
  山形市
- Year and Date
  2010-05-26
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 肝炎ウイルス研究のカッティングエッジ基礎から臨床への贈り物 E 型肝炎ウイルス研究の進歩2008
- Author(s)
  岡本宏明
- Organizer
  第12 回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19390134
[Presentation] 札幌市内3 医療機関に於ける最近10 年間の急性E 型肝炎の変遷2008
- Author(s)
  水尾仁志, 姜貞憲, 狩野吉康, 本城信吾, 松居剛志, 荒川智宏, 岡本宏明, 三代俊治
- Organizer
  第44 回日本肝臓学会総会
- Place of Presentation
  松山
- Year and Date
  2008-06-05
- Data Source
  KAKENHI-PROJECT-19390134
[Presentation] Viral genotyping/sequencing の臨床的意義Genotype 4 のE 型肝炎ウイルスの全長塩基配列の解析による劇症化に関連する塩基の同定2008
- Author(s)
  井上淳, 上野義之, 岡本宏明
- Organizer
  第12 回日本肝臓学会大会
- Place of Presentation
  東京
- Year and Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-19390134
[Presentation] 当院で経験した急性E 型肝炎の2 症例2007
- Author(s)
  岡野宏,西村晃,村田一素,岡本宏明
- Organizer
  第37 回日本肝臓学会西部会
- Place of Presentation
  長崎
- Year and Date
  2007-12-07
- Data Source
  KAKENHI-PROJECT-19390134
[Presentation] E型肝炎ウイルスの細胞侵入機構の解析
- Author(s)
  長嶋茂雄、吉林台、小林富成、唐吉思、高橋雅春、西澤勉、岡本宏明
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25860343

1. TAKAHASHI Masaharu (70326841)

# of Collaborated Projects : 7results

# of Collaborated Products : 45results
2. NISHIZAWA Tsutomu (30306112)

# of Collaborated Projects : 5results

# of Collaborated Products : 15results
3. NAGASHIMA Shigeo (60433116)

# of Collaborated Projects : 3results

# of Collaborated Products : 28results
4. KOBAYASHI Tominari (00634164)

# of Collaborated Projects : 3results

# of Collaborated Products : 11results
5. TANAKA Toshinori (30146154)

# of Collaborated Projects : 2results

# of Collaborated Products : 13results
6. MAYUMI Makoto (00049016)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. YASUDA Jiro (10282518)

# of Collaborated Projects : 1results

# of Collaborated Products : 3results
8. YASHIRO Takashi (80119859)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
9. KOUKI Tom (70350436)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
10. TOKITA Hajime (70254935)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. KOBAYASHI Eiji (00245044)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. MURAKAMI Takashi (00326852)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. KAWAMATA Yoji (00218380)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. TANAKA Koichi (20115877)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
15. KANEKO Takashi (10254913)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
16. IKEMOTO Shigenori (90048942)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
17. KAJII Eiji (40204391)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
18. 小池克郎 (30085625)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
19. 小原道法 (10250218)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. 小俣政男 (90125914)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. 吉倉廣 (60012754)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. 村上清史 (90019878)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

OKAMOTO Hiroaki 岡本 宏明

Research Projects

Research Products

Co-Researchers

Research on mechanism of hepatitis E virus egress utilizing membrane traffic

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Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles

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Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEVPrincipal Investigator

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Characterization of hepatitis E virus (HEV) particles and analysis of replication mechanism by using a cell culture system for HEVPrincipal Investigator

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Molecular epidemiological analysis of hepatitis E as a zoonosis and investigation toward its preventionPrincipal Investigator

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Development of genotyping method for TT virus (TTV) and its application to elucidation of pathogenesis.Principal Investigator

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Analysis of replication and transcription mechanisms in a newly discovered circular, single-stranded DNA virus (TTV)Principal Investigator

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Development for DNA vaccination against viral hepatitis recurrence after the liver transplantation using gene gun

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Research on genomic characteristics and disease associations of a newly discovered human serum hepatitis virus (TT virus)

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ANALYSIS OF GENOMIC STRUCTURE OF HEPATITIS G VIRUS (GBV-C/HGV) AND DEVELOPMENT OF SENSITIVE DETECTION SYSTEM OF THE VIRAL GENOMEPrincipal Investigator

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肝炎ウイルスの増殖と肝発がん

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PURIFICATION OF HEPATITIS C VIRUS PARTICLES AND ANALYSIS OF ITS STRUCTURAL PROTEINSPrincipal Investigator

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The production of monoclonal antibodies by mouse-mouse hybridoma cell lines and its application against blood grouping of the forensic materials.

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OKAMOTO Hiroaki 岡本宏明