TAKAHASHI Masaharu 高橋雅春

Researcher Number	70326841
Other IDs
External Links
Affiliation (Current)	2021: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2014: 自治医科大学, 医学部, 講師 2010 – 2012: 自治医科大学, 医学部, 講師 2008: 自治医科大学, 医学部・感染免疫学講座ウイルス学部門, 講師 2003 – 2008: JICHI MEDICAL SCHOOL, SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 講師 2000 – 2002: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Virology Except Principal Investigator Virology / Virology
Keywords	Principal Investigator E型肝炎ウイルス / reservoir / HEV RNA / ワクチン / 中和抗体 / 培養細胞 / E型肝炎 / 人獣共通感染症 / HEV抗体 / ブタ … More Except Principal Investigator E型肝炎ウイルス / 劇症肝炎 / TTV / 感染性cDNAクローン / 放出機構 / Tsg101 / 放出 / 遺伝子型 / PCR / TTウイルス(TTV) / 複製中間体 / mRNA / tandem dimer / transfection / 分子 / 細胞培養 / モノクローナル抗体 / 蛍光抗体法 / ORF3欠損変異ウイルス / ORF3抗原 / 中和抗体 / ORF2抗原 / 感染培養系 / 感染性 cDNA クローン / 感受性細胞 / 吸着 / 細胞レセプター候補分子 / ゲノム変異 / ORF3蛋白質 / PSAPモチーフ / MVB sorting / E 型肝炎ウイルス / 粒子形成 / MVB 経路 / Vps4 / エンドソーム輸送 / MVB経路 / ESCRT機構 / エクソソーム / 多胞体 / 出芽 / エクソソーム分泌経路 / エンベロープ / TTウイルス / 環状1本鎖DNA / 分子系統樹 / 肝疾患 / 肝外疾患 / TTV DNA量 / 特発性肺線維症 / 電子顕微鏡像 / チンパンジー感染実験 / TTV抗体 / DNAウイルス / 超可変領域 / 血清肝炎 / 塩基配列 / TTウイルス抗体 / 遺伝子変異 / TT virus / circular single-stranded DNA / genotype / phylogenetic group / liver disease / extrahepatic disease / 1本鎖環状DNAウイルス / 肺 / 肝臓 / 骨髄 / RFLP / 培養細胞 / 転写調節機構 / Transfection / 好中球 / circular single-stranded DNA virus / replicative intermediate / liver / E型肝炎 / 人畜共通感染症 / ELISA法 / IgAクラス抗HEV抗体 / 感染源 / 食感染 / 感染経路 / 核酸診断法 / IgAクラスHEV抗体 / 輸血感染 / Hepatitis E / Hepatitis E virus / Zoonosis / ELISA / IgA class anti-HEV / Infectious source / Food-borne transmission / Genotype Less

Research on mechanism of hepatitis E virus egress utilizing membrane traffic
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Characterization of cell culture-generated hepatitis E virus particles:evaluation of neutralizing antibodies-inducing ability as the material of inactivated vaccineproductionPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Masaharu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Characterization of hepatitis E virus (HEV) particles and analysis of replication mechanism by using a cell culture system for HEV
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Investigation of zoonotic infection of hepatitis E virus among mammalians and birdsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Masaharu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Molecular epidemiological analysis of hepatitis E as a zoonosis and investigation toward its prevention
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL
Analysis of replication and transcription mechanisms in a newly discovered circular, single-stranded DNA virus (TTV)
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Research on genomic characteristics and disease associations of a newly discovered human serum hepatitis virus (TT virus)
- Principal Investigator
  
  MAYUMI Makoto
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Virology
- Research Institution
  JICHI MEDICAL SCHOOL

All 2014 2013 2012 2011 2010 2009 2008 2007 2005 Other

All Journal Article Presentation Book

[Book] 肝・胆道系症候群(第2版)その他の肝・胆道系疾患を含めてI肝臓編(上)2010
- Author(s)
  高橋雅春(共著)
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22390090
[Book] 肝・胆道系症候群(第2版)その他の肝・胆道系疾患を含めてI肝臓編(上)2010
- Author(s)
  高橋雅春(共著)
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22590419
[Book] 肝・胆道系症候群(第2版)I 肝臓編(上) E型肝炎2010
- Author(s)
  高橋雅春, 岡本宏明
- Total Pages
  600
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines.2014
- Author(s)
  Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 185 Pages: 92-102
- DOI
  10.1016/j.virusres.2014.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.2014
- Author(s)
  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Pages: 2166-2175
- DOI
  10.1099/vir.0.066910-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Molecular characterization of a novel hepatitis E virus (HEV) strain obtained from a wild boar in Japan that is highly divergent from the previously recognized HEV strains2014
- Author(s)
  Takahashi M, Nishizawa T, Nagashima S, Jirintai S, Kawakami M, Sonoda Y, Suzuki T, Yamamoto S, Shigemoto K, Ashida K, Sato Y, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 180 Pages: 59-69
- DOI
  10.1016/j.virusres.2013.12.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] Marked genomic heterogeneity of rat hepatitis E virus strains in Indonesia demonstrated on a full-length genome analysis2014
- Author(s)
  Mulyanto, Suparyatmo JB, Andayani IG, Khalid, Takahashi M, Ohnishi H, Jirintai S, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 179 Pages: 102-112
- DOI
  10.1016/j.virusres.2013.10.029
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.2014
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Archives of Virology
  
  Volume: 159 Pages: 979-991
- DOI
  10.1007/s00705-013-1912-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan2014
- Author(s)
  Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中
- DOI
  10.1111/hepr.12216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] High genomic similarity between European type hepatitis E virus subgenotype 3e strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan2014
- Author(s)
  Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中
- DOI
  10.1111/hepr.12155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-25860343
[Journal Article] Frequent detectionand characterization of hepatitis E virusvariants in wild rats (Rattus rattus) inIndonesia.2013
- Author(s)
  Mulyanto
- Journal Title
  
  Arch Virol
  
  Volume: 158 Pages: 87-96
- DOI
  10.1007/s00705-012-1462-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Features of hepatitis E virus infection in humans and animals in Japan2013
- Author(s)
  Takahashi M, Okamoto H
- Journal Title
  
  Hepatol Res
- DOI
  10.1111/hepr.12175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Frequent detection and characterization of hepatitis E virus variants in wild rats (Rattus rattus) in Indonesia2013
- Author(s)
  Mulyanto, Depamede SN, Sriasih M, Takahashi M, Nagashima S, Jirintai S, Nishizawa T, Okamoto H
- Journal Title
  
  Arch Virol
  
  Volume: 158(1) Pages: 87-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food.2012
- Author(s)
  Takahashi H
- Journal Title
  
  Arch Virol
  
  Volume: 157 Pages: 235-246
- DOI
  10.1007/s00705-011-1153-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food2012
- Author(s)
  Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H
- Journal Title
  
  Arch Virol
  
  Volume: 157(2) Pages: 235-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution2012
- Author(s)
  Nakano T, Takahashi K, Pybus OG, Hashimoto N, Kato H, Okano H, Kobayashi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S.
- Journal Title
  
  Liver Int
  
  Volume: 32(4) Pages: 675-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Res
  
  Volume: 170(1-2) Pages: 126-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Icteric acute hepatitis Ewith no response of immunoglobulin M classanti-hepatitis E virus antibody.2012
- Author(s)
  Takikawa Y
- Journal Title
  
  Hepatol Res
  
  Volume: 42 Pages: 1146-1149
- DOI
  10.1111/j.1872-034x.2012.01023.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419
[Journal Article] Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan2012
- Author(s)
  Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H
- Journal Title
  
  Infect Genet Evol
  
  Volume: 12(7) Pages: 1524-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular analysis of hepatits E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  Jirintai S
- Journal Title
  
  Virus Res
  
  Volume: 170 Pages: 126-137
- DOI
  10.1016/j.virusres.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] Molecular epidemiology and genetic history ofEuropean-type genotype 3 hepatitis E virusindigenized in the central region of Japan.2012
- Author(s)
  Nakano T
- Journal Title
  
  Infect Genet Evol
  
  Volume: 12 Pages: 1524-1534
- DOI
  10.1016/j.meegid.2012.06.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419
[Journal Article] Icteric acute hepatitis E with no response of immunoglobulin M class anti-hepatitis E virus antibody2012
- Author(s)
  Takikawa Y, Miyamoto Y, Onodera M, Kuroda H, Kasai K, Miyasaka A, Takahashi M, Okamoto H, Suzuki K
- Journal Title
  
  Hepatol Res
  
  Volume: 42(11) Pages: 1146-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Analysis ofthe full-length genome of a hepatitis E virusisolate obtained from a wild boar in Japan thatis classifiable into a novel genotype2011
- Author(s)
  Takahashi M
- Journal Title
  
  J GenVirol
  
  Volume: 92 Pages: 902-908
- DOI
  10.1099/vir.0.029470-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419
[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for release of hepatitis E virions.2011
- Author(s)
  Nagashima S
- Journal Title
  
  J Gen Virol
  
  Volume: 92 Pages: 2838-2848
- DOI
  10.1099/vir.0.035378-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Journal Article] A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes2011
- Author(s)
  Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai, Nishizawa T, Okamoto H.
- Journal Title
  
  Arch Virol
  
  Volume: 156(8) Pages: 1345-58
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype2011
- Author(s)
  Takahashi M, Nishizawa T, Sato H, Sato Y, Jirintai, Nagashima S, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 4) Pages: 902-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] 北海道東部の釧路市および根室市におけるE型肝炎ウイルス感染の疫学調査:感染の地域差と食文化の相違について2011
- Author(s)
  田辺利男, 水尾仁志, 矢崎康幸, 高橋雅春, 岡本宏明
- Journal Title
  
  肝臓
  
  Volume: 52 Pages: 567-574
- NAID
  10029688070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] Tumour susceptibility gene 101 and the vacuolar protein sorting pathway are required for the release of hepatitis E virions.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 12) Pages: 2838-48
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A PSAPmotif in the ORF3 protein of hepatitis E virusis necessary for virion release from infectedcells2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T,Yamada K, Nishizawa T, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume: 92 Pages: 269-278
- DOI
  10.1099/vir.0.025791-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] Analysis of the full-length genome of a hepatitis E virus isolate obtained from a wild boar in Japan that is classifiable into a novel genotype.2011
- Author(s)
  Takahashi M
- Journal Title
  
  Journal of General Virology
  
  Volume: 92 Pages: 902-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Yamada K, Nishizawa T, Okamoto H
- Journal Title
  
  J Gen Virol
  
  Volume: 92(Pt 2) Pages: 269-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan : identification of boar HEV strains of genotype 3 and 4 and unrecognized genotypes2011
- Author(s)
  Sato Y
- Journal Title
  
  Arch Virol
  
  Volume: 156 Pages: 1345-1358
- DOI
  10.1007/s00705-011-0988-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419
[Journal Article] Hepatitis E Virus(REV)strains in serum samples can replicate efficiently incultured cells despite the coexistence of HEV antibodies : characterization of HEV virions in blood circulation.2010
- Author(s)
  Takahashi M
- Journal Title
  
  Journal of Clinical Microbiology
  
  Volume: 48 Pages: 1112-1125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] A nationwide survey of hepatitis E virus infection in the general population of Japan2010
- Author(s)
  Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H.
- Journal Title
  
  J Med Virol
  
  Volume: 82(2) Pages: 271-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Hepatitis E Virus (HEV) strains in serum samples can replicate efficiently in cultured cells despite the coexistence of HEV antibodies: characterization of HEV virions in blood circulation2010
- Author(s)
  Takahashi M, Tanaka T, Takahashi H, Hoshino Y, Nagashima S, Jirintai, Mizuo H, Yazaki Y, Takagi T, Azuma M, Kusano E, Isoda N, Sugano K, Okamoto H.
- Journal Title
  
  J Clin Microbiol
  
  Volume: 48(4) Pages: 1112-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Hepatitis E virus (HEV) strains in serum samples can replicate efficiently in cultured cell despite the coexistence of HEV antibodies : characterization of HEV virions in blood circulation.2010
- Author(s)
  Takahashi M
- Journal Title
  
  Journal of Clinical Microbiology
  
  Volume: 48 Pages: 1112-1125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] Hepatitis Evirus (HEV) strains in serum samples canreplicate efficiently in cultured cells despitethe coexistence of HEV antibodies:characterization of HEV virions in bloodcirculation.2010
- Author(s)
  Takahashi M, Tanaka T, Takahashi H,Hoshino Y, Nagashima S, Jirintai, Mizuo H,Yazaki Y, Takagi T, Azuma M, Kusano E,Isoda N, Sugano K, Okamoto H
- Journal Title
  
  J Clin Microbiol
  
  Volume: 48 Pages: 1112-1125
- DOI
  10.1128/jcm.02002-09
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] 札幌圏内小流行4 型HEV株が検出された茨城県内E型肝炎の1例2010
- Author(s)
  相川達也, 池澤和人, 間宮孝, 上野ちさと, 和田由美子, 島田沙香, 津田文男, 高橋雅春, 岡本宏明
- Journal Title
  
  肝臓
  
  Volume: 51 Pages: 579-581
- NAID
  10027469901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia2010
- Author(s)
  Jinshan, Jirintai, Manglai D, Takahashi M, Nagashima S, Okamoto H
- Journal Title
  
  China. Arch Virol
  
  Volume: 155(8) Pages: 1217-26
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular andserological survey of hepatitis E virusinfection among domestic pigs in InnerMongolia2010
- Author(s)
  Jinshan, Jirintai, Manglai D, Takahashi M,Nagashima S, Okamoto H
- Journal Title
  
  China. Arch Virol
  
  Volume: 155 Pages: 1217-1226
- DOI
  10.1007/s00705-010-0706-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590419
[Journal Article] ORF3 protein of hepatitis E virus is essential for virion release from infected cells.2009
- Author(s)
  Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  J Gen Virol doi:10.1099/Vir.0.010561-0(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan.2009
- Author(s)
  Inoue J, Ueno Y, Nagasaki F, Akahane T, Fukushima K, Kogure T, Kondo Y, Kakazu E, Tamai K, Kido O, Nakagome Y, Ninomiya M, Obara N, Wakui Y, Takahashi M, Okamoto H, Shimosegawa T
- Journal Title
  
  J Gastroenterol 44
  
  Pages: 329-337
- NAID
  10025174367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Development and characterization of a genotype 4 hepatitis E virus cell culture system using the HE-JF5/15F strain recovered from a fulminant hepatitis patient.2009
- Author(s)
  Tanaka T, Takahashi M, Takahashi H, Ichiyama K, Hoshino Y, Nagashima S, Mizuo H, Okamoto H
- Journal Title
  
  J Clin Microbiol 47
  
  Pages: 1906-1910
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells.2009
- Author(s)
  Yamada K, Takahashi M, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  J Gen Virol 90(2)
  
  Pages: 457-462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Production of monoclonal antibodies against hepatitis E virus capsid protein and evaluation of their neutralizing activity in a cell culture system.2008
- Author(s)
  Takahashi M, Hoshino Y, Tanaka T, Takahashi H, Nishizawa T, Okamoto H
- Journal Title
  
  Arch Virol 153
  
  Pages: 657-666
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Monoclonal antibodies raised against the ORF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.2008
- Author(s)
  Takahashi M, Yamada K, Hoshino Y, Takahashi H, Ichiyama K, Tanaka T, Okamoto H
- Journal Title
  
  Arch Virol 153
  
  Pages: 1703-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Monoclonal antibodies raised against the 0RF3 protein of hepatitis E virus (HEV) can capture HEV particles in culture supernatant and serum but not those in feces.2008
- Author(s)
  Takahashi M
- Journal Title
  
  Archives of Virology 153
  
  Pages: 1703-1713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Mutational events during the primary propagation and consecutive passages of hepatitis E virus strain JE03-1760F in cell culture.2008
- Author(s)
  Lorenzo FR, Tanaka T, Takahashi H, Ichiyama K, Hoshino Y, Yamada K, Inoue J, Takahashi M, Okamoto H
- Journal Title
  
  Virus Res 137
  
  Pages: 86-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Development and evaluation of an efficient cell-culture system for Hepatitis E virus.2007
- Author(s)
  Tanaka T, Takahashi M, Kusano E, Okamoto H.
- Journal Title
  
  J Gen Virol 88
  
  Pages: 903-911
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system.2007
- Author(s)
  Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H
- Journal Title
  
  J Clin Microbiol 45(11)
  
  Pages: 3671-3679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Analysis of the full-length genome of hepatitis E virus isolates obtained from farm pigs in Mongolia.2007
- Author(s)
  Lorenzo FR, Tsatsralt-Od B, Ganbat S, Takahashi M, Okamoto H
- Journal Title
  
  J Med Virol 79
  
  Pages: 1128-1137
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Identification of genotype 4 hepatitis E virus strains from a patient with acute hepatitis E and farm pigs in Bali, Indonesia.2007
- Author(s)
  Wibawa IDN, Suryadarma IGA, Mulyanto, Tsuda F, Matsumoto Y, Ninomiya M, Takahashi M, Okamoto H
- Journal Title
  
  J Med Virol 79
  
  Pages: 1138-1146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Prolonged fecal shedding of hepatitis E virus(HEV)druing sporadic acute hepatitis E:evaluation of infectivity of HEV in fecal specimens in a cell culture system.2007
- Author(s)
  Takahashi M
- Journal Title
  
  Journal of Clinical Microbiology 45
  
  Pages: 3671-3679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Ongoing subclinical infection of hepatitis E virus among blood donors with an elevated alanine aminotransferase level in Japan.2007
- Author(s)
  Gotanda Y, Iwata A, Ohnuma H, Yoshikawa A, Mizoguchi H, Endo K, Takahashi M, Okamoto H
- Journal Title
  
  J Med Virol 79
  
  Pages: 734-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006.2007
- Author(s)
  Fukuda S, Ishikawa M, Ochiai N, Suzuki Y, Sunaga J, Shinohara N, Nozawa K, Tsuda F, Takahashi M, Okamoto H
- Journal Title
  
  Arch Virol 152
  
  Pages: 1623-1635
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390134
[Journal Article] Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific diagnosis of acute HEV infection2005
- Author(s)
  Takahashi M.
- Journal Title
  
  Journal of Clinical Microbiology 43
  
  Pages: 49-56
- Data Source
  KAKENHI-PROJECT-16390137
[Journal Article] Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan2005
- Author(s)
  Takahashi M.
- Journal Title
  
  Journal of General Virology 86-6
  
  Pages: 1807-1813
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590421
[Journal Article] Simultaneous detection of immunoglobulin A (IgA) and IgM antibodes against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection2005
- Author(s)
  Takahashi M
- Journal Title
  
  Journal of Clinical Microbiology 43
  
  Pages: 49-56
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390137
[Journal Article] Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection.2005
- Author(s)
  Takahashi M, et al.
- Journal Title
  
  J Clin Microbiol 43
  
  Pages: 49-56
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390137
[Journal Article] Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan.2005
- Author(s)
  Takahashi M.
- Journal Title
  
  Journal of General Virology 86・6
  
  Pages: 1807-1813
- Data Source
  KAKENHI-PROJECT-16390137
[Journal Article] Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan2005
- Author(s)
  Takahashi M.
- Journal Title
  
  Journal of General Virology 86・6
  
  Pages: 1807-1813
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590421
[Journal Article] Simultaneous detection of immunoglobulin A (IgA) and IgM antibodies against hepatitis E virus (HEV) is highly specific for diagnosis of acute HEV infection2005
- Author(s)
  Takahashi M.
- Journal Title
  
  Journal of Clinical Microbiology 43・1
  
  Pages: 49-56
- Data Source
  KAKENHI-PROJECT-17590421
[Journal Article] A high genomic similarity between European type hepatitis E virus subgenotype 3e Jirintai S, Jinshan, Tanggis, Manglai 18. strains isolated from an acute hepatitis patient and a wild boar in Mie, Japan
- Author(s)
  Okano H, Nakano T, Sugimoto K, Takahashi K, Nagashima S, Takahashi M, Arai M, Okamoto H
- Journal Title
  
  Jinshan, Tanggis, Manglai
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] 細胞内膜輸送系を利用したE型肝炎ウイルスの放出機構の解析2013
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、小林富成、西澤勉、岡本宏明
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860343
[Presentation] 培養細胞から放出された E 型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、西澤勉、小林富成、岡本宏明
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H
- Organizer
  15thInternational Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and the vacuolar protein sorting pathway are required for virion release of hepatitis E virus.2011
- Author(s)
  Nagashima S, Takahashi M, Jirintai, Tanaka T, Nishizawa T, Yasuda J, Okamoto H.
- Organizer
  15th International Congress of Virology (第59回日本ウイルス学会学術集会)
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] Tsg101 and vacuolar protein sorting pathway are required for virion release of hepatitis E virus2011
- Author(s)
  Nagashima, S., Takahashi, M., Jirintai, Tanaka, T., Nishizawa, T., Yasuda J, Okamoto, H
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-22390090
[Presentation] E型肝炎ウイルスの細胞侵入機構の解析
- Author(s)
  長嶋茂雄、吉林台、小林富成、唐吉思、高橋雅春、西澤勉、岡本宏明
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25860343

1. OKAMOTO Hiroaki (30177092)

# of Collaborated Projects: 7 results

# of Collaborated Products: 45 results
2. NISHIZAWA Tsutomu (30306112)

# of Collaborated Projects: 4 results

# of Collaborated Products: 15 results
3. NAGASHIMA Shigeo (60433116)

# of Collaborated Projects: 3 results

# of Collaborated Products: 28 results
4. KOBAYASHI Tominari (00634164)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
5. TANAKA Toshinori (30146154)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
6. YASUDA Jiro (10282518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. YASHIRO Takashi (80119859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. KOUKI Tom (70350436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. MAYUMI Makoto (00049016)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAHASHI Masaharu 高橋 雅春

Research Projects

Research Products

Co-Researchers

Research on mechanism of hepatitis E virus egress utilizing membrane traffic

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Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles

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Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV

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Characterization of cell culture-generated hepatitis E virus particles:evaluation of neutralizing antibodies-inducing ability as the material of inactivated vaccineproductionPrincipal Investigator

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Characterization of hepatitis E virus (HEV) particles and analysis of replication mechanism by using a cell culture system for HEV

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Investigation of zoonotic infection of hepatitis E virus among mammalians and birdsPrincipal Investigator

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Molecular epidemiological analysis of hepatitis E as a zoonosis and investigation toward its prevention

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Analysis of replication and transcription mechanisms in a newly discovered circular, single-stranded DNA virus (TTV)

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Research on genomic characteristics and disease associations of a newly discovered human serum hepatitis virus (TT virus)

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[Book] 肝・胆道系症候群(第2版)その他の肝・胆道系疾患を含めてI肝臓編(上)2010

Author(s)

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Data Source

[Book] 肝・胆道系症候群(第2版)その他の肝・胆道系疾患を含めてI肝臓編(上)2010

Author(s)

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Data Source

[Book] 肝・胆道系症候群(第2版)I 肝臓編(上) E型肝炎2010

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Total Pages

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[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.2014

Author(s)

Journal Title

DOI

TAKAHASHI Masaharu 高橋雅春