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Miyagishi Makoto  宮岸 真

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宮岸 真  ミヤギシ マコト

MIYAGISHI Makoto  宮岸 真

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Researcher Number 30323538
Other IDs
Affiliation (Current) 2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
Affiliation (based on the past Project Information) *help 2022: 国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員
2017: 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長
2017: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長
2016: 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究チーム長
2016: 国立研究開発法人・産業技術総合研究所, バイオメディカル研究部門, グループ長 … More
2015: 国立研究開発法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長
2014: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長
2007: 東京大学, 医学部附属病院, 特任准教授
2007: 東京大学, 大学院・医学系研究科, 特任准教授
2007: The University of Tokyo, 21st Century COE Program, School of Medicine, Associate professor
2006: 東京大学, 大学院医学系研究科21世紀COEプログラム特任, 助教授
2004 – 2006: 東京大学, 医学部附属病院, 特任助教授
2005: 東京大学, 大学院・医学系研究科21世紀COEプログラム特任, 助教授
2004: 東京大学, 大学院・工学系研究科, 特任助教授
2001 – 2003: 東京大学, 大学院・工学系研究科, 助手 Less
Review Section/Research Field
Principal Investigator
Biomedical engineering/Biomaterial science and engineering / Biomedical engineering/Biological material science / Tumor diagnostics
Except Principal Investigator
Medium-sized Section 37:Biomolecular chemistry and related fields / Drug development chemistry / Gastroenterology / 生物・生体工学 / Structural biochemistry / Pediatrics / Biological Sciences
Keywords
Principal Investigator
siRNA / 核酸アプタマー / RNA / DNA / Biotechnology / RNA interference / Interferon Response / RNAiライブラリー / アポトシス / ジーンディスカバリー … More / バイオテクノロジー / RNA干渉 / インターフェロン応答 / miRNA / バイオマーカー / 癌 / エキソソーム … More
Except Principal Investigator
small interference RNA / RNA工学 / リボザイム / アポトーシス / siRNA / 感染症 / 遺伝子治療 / アポトシス / ジーンディスカバリー / リガーゼ / 進化分子工学 / RNA / モルヒネ / 新規核酸アプタマー探索法 / 鎮痛効果 / 膜小胞 / 新規核酸リガンド探索法 / G蛋白質受容体 / DNAアプタマー / Cell SELEX法 / 創薬基盤技術 / 鎮痛 / 探索方法 / オピオイド受容体 / GPCRs / DNA / アプタマー / RNA technology / antiviral drug / Hepatitis B virus / ウイルス複製 / マウス / 創薬 / 抗ウイルス薬 / B型肝炎ウイルス / Metastasis / Alzheimer Disease / apoptosis / Gene Discovery / Ribozyme / 遺伝子破壊 / 慢性骨髄性白血病 / ハンマーヘッドリボザイム / ジーン・ディスカバリー / RNAヘリカーゼ / poly A / RNAヘリケース / がん転移 / アルツハイマー病 / タンパク質核酸相互作用 / がん / 核酸創薬 / 転写因子 / PKCα / MAPK / アデノウイルス / 母乳 / 遺伝子 / ウイルス / polIII系 / がん遺伝子 / U6プロモーター / pol III系 / RNA interference / RNAiライブラリー / RNA干渉 Less
  • Research Projects

    (10 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (13 People)
  •  RNA分解産物をリサイクルするリガーゼリボザイムの創出

    • Principal Investigator
      加藤 義雄
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of simple and high-performance DNA/RNA chimeric nucleic acid aptamerPrincipal Investigator

    • Principal Investigator
      MIYAGISHI Makoto
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biomedical engineering/Biomaterial science and engineering
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Creation of novel DNA ligands with potent analgesic action against MOR opioid receptor and elucidation of molecular mechanisms.

    • Principal Investigator
      IKEMOTO Mitsushi
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Indentifiation of nucleic acid aptamers which specifically recognize cancer-derived exosomes and its application for diagnosticsPrincipal Investigator

    • Principal Investigator
      Miyagishi Makoto
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor diagnostics
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of nucleic acids therapeutics against multiple domains of transcription factor SATB1

    • Principal Investigator
      YAMASAKI Kazuhiko
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  小児ウイルス感染症制御に向けてのsiRNAおよびmiRNAによるアプローチ

    • Principal Investigator
      牛島 廣治
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      The International University of Kagoshima
      The University of Tokyo
  •  The study of anti-hepatitis B virus drugs using RNA technology

    • Principal Investigator
      KIMURA Kiminori
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      The University of Tokyo
      Gifu University
  •  Systematic and Comprehensive Analysis of Interferon Response induced by siRNAPrincipal Investigator

    • Principal Investigator
      MIYAGISHI Makoto
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      The University of Tokyo
  •  Pol III発現系を用いた哺乳動物細胞におけるRNA干渉の開発とがん治療への応用

    • Principal Investigator
      TAIRA Kazunari
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Development of functional analysis of genes in cells using functional nucleic acids

    • Principal Investigator
      TAIRA Kazunari
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      生物・生体工学
    • Research Institution
      University of Tokyo

All 2017 2016 2014 2006 2005 2004

All Journal Article Presentation Book

  • [Book] Design of intracellularly active ribozymes and siRNAs. In "Non-viral Gene Therapy : Gene Design and Delivery" (Taira, K., Kataoka, K., Niidome, T.(Eds.),)2005

    • Author(s)
      Miyagishi, M., Taira, K.
    • Publisher
      Springer-Verlag Tokyo
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Biochemical and structural features of extracellular vesicle-binding RNA aptamers2017

    • Author(s)
      Murakami K, Zhao J, Yamasaki K and Miyagishi M
    • Journal Title

      Biomedical Reports

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16K12903
  • [Journal Article] Intracellular-diced dsRNA has enhanced efficacy for silencing HCV RNA and overcomes variation in the viral genotype.2006

    • Author(s)
      Watanabe T, Sudoh M, Miyagishi M, Akasi H, Arai M, Inoue K, Taira K, Yoshiba M, Kohara M.
    • Journal Title

      Gene Ther. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Intracellular-diced dsRNA has enhanced efficacy for silencing HCV RNA and overcomes variation in the viral genotype.2006

    • Author(s)
      Watanabe T, Sudoh M, Miyagishi, M., Akashi H, Arai M, Inoue K, Taira, K, Yoshiba M, Kohara M
    • Journal Title

      Gene Ther. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Intracellular-diced dsRNA has enhanced efficacy for silencing HCV RNA and overcomes variation in the viral genotype.2006

    • Author(s)
      Watanabe T, Sudoh M, Miyagishi M, Akashi H, Arai M, Inoue K, Taira K, Yoshiba M, Kohara M.
    • Journal Title

      Gene Ther. (in press)

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] A20 is a negative regulator of IFN regulatory factor 3 signaling.2005

    • Author(s)
      Saitoh, T., Yamamoto, M., Miyagishi, M., Taira, K., Nakanishi, M., Fujuta, T., Akira, S., Yamamoto, N., Yamaoka, S.
    • Journal Title

      Journal of Immunology 174

      Pages: 1507-1512

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference.2005

    • Author(s)
      Suminoto, H., Yamagata, S., Shimizu, A., Miyoshi, H., Mizuguchi, H., Hayakawa, T., Miyagishi, M., Taira, K., Kawakami, Y.
    • Journal Title

      Gene Ther. 12

      Pages: 95-100

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] siRNA becomes smart and intelligent.2005

    • Author(s)
      Miyagishi, M., Taira, K.
    • Journal Title

      Nature Biotech. 23

      Pages: 946-947

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] A20 is a negative regulator of IFN regulatory factor 3 signaling.2005

    • Author(s)
      Saitoh, T., Yamamoto, M., Miyagishi, M., Taira, K., Nakanishi, M., Fujita, T., Akira, S., Yamamoto, N., Yamaoka, S.
    • Journal Title

      Journal of Immunology 174

      Pages: 1507-1512

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA2005

    • Author(s)
      Akashi, H., Miyagishi, M, Yokota, T., Watanabe, T., Hino, T., Nishina, K., Kohara, M., Taira, K.
    • Journal Title

      Mol. BioSyst. 1

      Pages: 382-389

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] siRNA becomes smart and intelligent.2005

    • Author(s)
      Miyagishi, M., Taira, K.
    • Journal Title

      Nature Biotech 23

      Pages: 946-947

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] siRNA becomes smart and intelligent.2005

    • Author(s)
      Miyagishi, M., Taira, K
    • Journal Title

      Nature Biotech. 23

      Pages: 946-947

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library.2005

    • Author(s)
      Matsumoto, S., Miyagishi, M., Akashi, H., Nagai, R., Taira, K.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 25687-25696

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA2005

    • Author(s)
      Akashi, H., Miyagishi, M., Yokota, T., Watanabe, T., Hino, T., Nishina, K., Kohara, M., Taira, K.
    • Journal Title

      Mol. BioSyst. 1

      Pages: 382-389

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Genome-wide application of RNAi to the discovery of potential drug targets.2005

    • Author(s)
      Ito, M., Kawano, K., Miyagishi, M., Taira, K.
    • Journal Title

      Gene Ther. 12

      Pages: 95-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library.2005

    • Author(s)
      Matsumoto, S., Miyagishi, M, Akashi, H., Nagai, R., Taira, K.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 25687-25696

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Genome-wide application of RNAi to the discovery of potential drug targets.2005

    • Author(s)
      Ito, M, Kawano, M., Miyagishi, M., Taira, K.
    • Journal Title

      Gene Ther. 12

      Pages: 95-100

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA2005

    • Author(s)
      Akashi, H., Miyagishi, M., Yokota, T., Watanabe, T., Hino, T., Nishina, K., Kohara, M., Taira, K.
    • Journal Title

      Mol.BioSyst. 1

      Pages: 382-389

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library.2005

    • Author(s)
      Matsumoto, S., Miyagishi, M, Akashi, H., Nagai, R., Taira, K.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 25687-25696

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Gene therapy for human small-cell lung carcinoma by inactivation of Skp-2 with virally mediated RNA interference.2005

    • Author(s)
      Sumimoto, H., Yamagata, S., Shimizu, A., Miyoshi, H., Mizuguchi, H., Hayakawa, T., Miyagishi, M., Taira, K, Kawakami, Y.
    • Journal Title

      Gene Ther. 12

      Pages: 95-100

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.2004

    • Author(s)
      Yoneyama, M., Kikuchi, M., Natsukawa, T., Shinobu, N., Imaizumi, T., Miyagishi, M., Taira, K., Akira, S., Fujita, T.
    • Journal Title

      Nature Immunol. 5

      Pages: 730-737

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Control of siRNA expression using the Cre-loxP recombination system.2004

    • Author(s)
      Kasim V., Miyagishi M., Taira K.
    • Journal Title

      Nucleic Acids Res. 32

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Identification of metastasis-related genes using a library of randomized ribozymes in a mouse model.2004

    • Author(s)
      Suyama, E., Wadhwa, R., Kaur, K., Miyagishi, M., Kaul, S.C., Kawasaki, H., Taira, K.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 38083-38086

    • Data Source
      KAKENHI-PROJECT-14030011
  • [Journal Article] A20 is a negative regulator of interferon regulatory factor 3 signaling.2004

    • Author(s)
      Saitoh, T., Yamamoto, M., Miyagishi, M., Taira, K., Nakanishi, M., Fujita, T., kira, S., Yamamoto, N., Yamaoka, S.
    • Journal Title

      Journal of Immunology 174

      Pages: 1507-1512

    • Data Source
      KAKENHI-PROJECT-14030011
  • [Journal Article] Identification of a network involved in thapsigargin-induced apoptosis using a library of siRNA-expression vectors.2004

    • Author(s)
      Futami, T., Miyagishi, M., Taira, K.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 826-831

    • Data Source
      KAKENHI-PROJECT-14030011
  • [Journal Article] Generation of shRNAi expression library against the whole human transcripts.2004

    • Author(s)
      Miyagishi, M., Matsumoto, S., Taira, K.
    • Journal Title

      Virus Res. 102

      Pages: 117-124

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells.2004

    • Author(s)
      Miyagishi, M., Sumimoto, H., Miyoshi, H., Kawakami, Y., Taira, K.
    • Journal Title

      Journal of Gene Medicine 6

      Pages: 715-723

    • Data Source
      KAKENHI-PROJECT-14030011
  • [Journal Article] Effects on RNAi of the tight structure, sequence and position of the targeted region.2004

    • Author(s)
      Yoshinari, K., Miyagishi, M., Taira, K.
    • Journal Title

      Nucleic Acids Res. 32

      Pages: 691-699

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Optimization of an siRNA-expression system with an improved hairpin and its significant suppressive effects in mammalian cells.2004

    • Author(s)
      Miyagishi, M., Sumimoto, H., Miyoshi, H., Kawakami Y., Taira, K.
    • Journal Title

      Journal of Gene Medicine 6

      Pages: 715-723

    • Data Source
      KAKENHI-PROJECT-16300151
  • [Journal Article] Know-how of RNA interference and its applications in research and therapy.2004

    • Author(s)
      Wadhwa, R., Kaul, S.C., Miyagishi, M., Taira, K.
    • Journal Title

      Mutat.Res. 567

      Pages: 71-84

    • Data Source
      KAKENHI-PROJECT-14030011
  • [Presentation] 核酸アプタマーを用いたエキソソームの精製法の検討2016

    • Author(s)
      猪股 梨華、Zhao Jing、宮岸 真
    • Organizer
      LS-BT合同研究発表会
    • Place of Presentation
      つくば
    • Year and Date
      2016-02-01
    • Data Source
      KAKENHI-PROJECT-26640097
  • [Presentation] ストレプトアビジンに対する新規Gカルテット核酸アプタマーの同定と特性解析2016

    • Author(s)
      猪股 梨華、Zhao Jing、山崎 和彦、宮岸 真
    • Organizer
      日本核酸医薬学会
    • Place of Presentation
      千葉県野田市東京理科大学葛飾キャンパス図書館大ホール
    • Year and Date
      2016-11-15
    • Data Source
      KAKENHI-PROJECT-16K12903
  • [Presentation] 細胞外ベシクルに結合するRNAアプタマーの生化学的および構造学的特徴2014

    • Author(s)
      村上 和由、Zhao Jing、山崎 和彦、池本 光志、宮岸 真
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-27
    • Data Source
      KAKENHI-PROJECT-26640097
  • 1.  YAMASAKI Kazuhiko (00358243)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 2.  TAIRA Kazunari (10261778)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 3.  OKADA Tomoko (30344146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  KAWASAKI Hiroaki (60332623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KURATA Hiroyuki (90251371)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  AWAI Shigenori (10168544)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  KIMURA Kiminori (70397339)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  MORIWAKI Hisataka (50174470)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NAGAKI Masahito (30293559)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  IKEMOTO Mitsushi (50356424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  ISHII Noriyuki (10261174)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  牛島 廣治 (10091068)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  加藤 義雄 (20415657)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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