NAKAJIMA Hidemitsu 中嶋秀満

Researcher Number	30405360
Other IDs
Affiliation (Current)	2022: 大阪公立大学, 大学院獣医学研究科 , 准教授
Affiliation (based on the past Project Information) *help	2015 – 2019: 大阪府立大学, 生命環境科学研究科, 准教授 2012 – 2015: 大阪府立大学, 生命環境科学研究科(系), 准教授 2010 – 2012: 大阪府立大学, 生命環境科学研究科, 准教授 2011: 大阪府立大学, 大学院・生命環境科学研究科, 准教授 2011: 大阪府立大学, 生命環境科学研究科・獣医学専攻, 准教授 2009: 生命環境科学研究科, 助教 2007 – 2009: Osaka Prefecture University, 生命環境科学研究科, 助教
Review Section/Research Field	Principal Investigator Basic veterinary science/Basic zootechnical science / Veterinary medical science / Veterinary medical science, Animal science, and related fields Except Principal Investigator Physical pharmacy / Applied pharmacology / Applied veterinary science / Biomedical engineering/Biological material science / Veterinary medical science / Biomedical engineering/Biomaterial science and engineering / Neurochemistry/Neuropharmacology
Keywords	Principal Investigator 酸化ストレス / GAPDH / 凝集 / アミロイド / 薬理 / 神経変性疾患 / トランスジェニックマウス / 脳神経疾患 / アルツハイマー病 / 創薬 … More Except Principal Investigator DDS / 難水溶性薬剤 / 生体内輸送蛋白質 / 輸送蛋白質 / がん / 標的指向性 / SN-38 / 脳神経疾患 / ドラッグデリバリーシステム / がんターゲット / 難水溶性抗がん剤 / ターゲッティング / 疾病予防・制御 / 新規治療薬開発 / ボツリヌス菌 / C3酵素 / てんかん / パーキンソン病 / ボツリヌス毒素 / ポリグルタミン病 / 輸送タンパク質 / 薬理 / 神経科学 / シグナル伝達 / 獣医学 / ポリADPリボース / グリア細胞 / 神経栄養因子 / ＧDNF / 神経保護 / タンパク質ナノカプセル / 癌指向性 / 薬物送達システム / 生体内輸送タンパク質 / ナノカプセル / リポカリンタンパク質 / リポカリン蛋白質 / 活性イオウ分子 / レドックスシグナル / 神経変性 / 活性イオウ分子種 / 細胞内情報伝達 / レドックッスシグナル Less

最新ゲノム編集法によるネコ型GAPDHノックイン新規アルツハイマー病モデルの開発Principal Investigator
- Principal Investigator
  
  中嶋秀満
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Veterinary medical science, Animal science, and related fields
- Research Institution
  Osaka Prefecture University
Regulation of redox signaling by reactive sulfur species in nervous system
- Principal Investigator
  
  Ihara Hideshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Osaka Prefecture University
ＧＡＰＤＨカスケードを基軸としたストレス性精神疾患の発症機序解明と治療戦略の構築Principal Investigator
- Principal Investigator
  
  中嶋秀満
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Osaka Prefecture University
A neurotrophic role of extracellular poly (ADP-ribose) in neurological sdisorders
- Principal Investigator
  
  Takeuchi Tadayoshi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Osaka Prefecture University
A novel therapeutic target for neurological disoders by inhibition of GAPDH aggregationPrincipal Investigator
- Principal Investigator
  
  Nakajima Hidemitsu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Veterinary medical science
- Research Institution
  Osaka Prefecture University
Development of poorly water-soluble drug encapsulated protein nanocapsule possessing cancer directivity and application to DDS
- Principal Investigator
  
  Inui Takashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka Prefecture University
Research for therapeutic application of dominant negative GAPDH molecule on oxidative stress-induced disorderPrincipal Investigator
- Principal Investigator
  
  NAKAJIMA Hidemitsu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Osaka Prefecture University
Development of intelligent-type drug delivery system by transporter protein.
- Principal Investigator
  
  INUI Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Physical pharmacy
  Applied pharmacology
- Research Institution
  Osaka Prefecture University
Preclinical study for the therapeutic application of botulinum neurotoxin to intractable brain disorders.
- Principal Investigator
  
  KOZAKI Syunji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Osaka Prefecture University
Development of drug delivery system using intravital transporter protein.
- Principal Investigator
  
  TAKASHI Inui
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Osaka Prefecture University
Role of GAPDH amyloid-like fibrils formation in neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  NAKAJIMA Hidemitsu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Osaka Prefecture University

All 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Book Patent

[Book] 解糖系酵素glyceraldehyde-3-phosphate dehydrogenase (GAPDH)の多機能性と酸化ストレス性細胞死における役割2010
- Author(s)
  中嶋秀満、東泰孝、竹内正吉
- Total Pages
  12
- Publisher
  放射線生物研究
- Data Source
  KAKENHI-PROJECT-22580339
[Journal Article] Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo.2017
- Author(s)
  Nakajima H, Itakura M, Sato K, Nakamura S, Azuma YT, Takeuchi T.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 484 Pages: 385-389
- DOI
  10.1016/j.bbrc.2017.01.129
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05029, KAKENHI-PROJECT-15K14857
[Journal Article] Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction During Oxidative Stress-Induced Cell Death2017
- Author(s)
  Nakajima H, Itakura M, Kubo T, Kaneshige A, Harada N, Izawa T, Azuma YT, Kuwamura M, Yamaji R, Takeuchi T.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Pages: 4727-4742
- DOI
  10.1074/jbc.m116.759084
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05029, KAKENHI-PROJECT-15J05838
[Journal Article] Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death.2016
- Author(s)
  Kubo T., Nakajima H., Nakatsuji M., Itakura M., Kaneshige A., Azuma Y. T., Inui T., and Takeuchi T.
- Journal Title
  
  Nitric Oxide, Biology and Chemistry
  
  Volume: 53 Pages: 13-21
- DOI
  10.1016/j.niox.2015.12.005
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25242046, KAKENHI-PROJECT-25450428, KAKENHI-PROJECT-25660231
[Journal Article] Glyceraldehyde-3-Phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease.2015
- Author(s)
  Itakura, M., Nakajima, H., Kubo, T., Semi, Y., Kume, S., Higashida, S., Kaneshige, A., Kuwamura, M., Harada, N., Kita, A., Azuma, Y. T., Yamaji, R., Inui, T., Takeuchi, T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Pages: 26072-26087
- DOI
  10.1074/jbc.m115.669291
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25242046, KAKENHI-PROJECT-15J05838, KAKENHI-PROJECT-25450428, KAKENHI-PROJECT-25660231
[Journal Article] Glyceraldehyde-3-phosphate dehydrogenase aggregation inhibitor peptide: A potential therapeutic strategy against oxidative stress-induced cell death.2015
- Author(s)
  Itakura M, Nakajima H, Semi Y, Higashida S, Azuma YT, Takeuchi T.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 2015 Pages: 373-376
- DOI
  10.1016/j.bbrc.2015.09.150
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450428
[Journal Article] Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade.2015
- Author(s)
  Tristan C.A., Ramos A., Shahani N., Emiliani F.E., Nakajima H., Noeh C.C., Kato Y., Takeuchi T., Noguchi T., Kadowaki H., Sedlak T.W., Ishizuka K., Ichijo H., Sawa, A.
- Journal Title
  
  J Biol Chem.
  
  Volume: 290 Pages: 56-64
- DOI
  10.1074/jbc.m114.596205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870562, KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-25450428
[Journal Article] Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke.2015
- Author(s)
  Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma Y, Inui T, Kamiya A, Sawa A, Takeuchi T
- Journal Title
  
  J Biol Chem.
  
  Volume: VOL. 290 Pages: 14493-14503
- DOI
  10.1074/jbc.m114.635607
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23120011, KAKENHI-PROJECT-25242046, KAKENHI-PROJECT-25450428, KAKENHI-PROJECT-25660231, KAKENHI-PROJECT-15H04275
[Journal Article] Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase2012
- Author(s)
  Fukuhara, A., Nakajima, H., Miyamoto, Y., Inoue, K., Kume, S., Lee, YH., Noda, M., Uchiyama, S., Shimamoto, S., Nishimura, S., Ohkubo, T., Goto, Y., Takeuchi, T., and Inui, T.
- Journal Title
  
  J. Control. Release
  
  Volume: 159巻 Pages: 143-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500428
[Journal Article] Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase2012
- Author(s)
  Fukuhara, A., Nakajima, H., Miyamoto, Y., Inoue, K., Kume, S., Lee, YH., Noda, M., Uchiyama, S., Shimamoto, S., Nishimura, S., Ohkubo, T., Goto, Y., Takeuchi, T., and Inui, T. (correspondence author)
- Journal Title
  
  J. Control. Release
  
  Volume: 159 巻 Pages: 143-150
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200076
[Journal Article] A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in theadult rat brain.2012
- Author(s)
  Hidemitsu Nakajima, Takeya Kubo, Yuko Semi, Masanori Itakura, Mitsuru Kuwamura, Takeshi Izawa, Yasu-Taka Azuma and Tadayoshi Takeuchi
- Journal Title
  
  J. Biotechnol
  
  Volume: 157 Pages: 326-333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580339
[Journal Article] A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain2012
- Author(s)
  Nakajima H, Kubo T, Semi Y, Itakura M, Kuwamura M, Izawa T, Azuma YT, Takeuchi T
- Journal Title
  
  Journal of Biotechnology
  
  Volume: 152(2) Pages: 326-333
- DOI
  10.1016/j.jbiotec.2011.10.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22580339
[Journal Article] A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain2012
- Author(s)
  Nakajima, H., Kubo, T., Semi, Y., Itakura, M., Kuwamura, M., Izawa, T., Azuma, YT., Takeuchi, T.
- Journal Title
  
  J. Biotech
  
  Volume: 157 Pages: 326-333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380188
[Journal Article] Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death2012
- Author(s)
  Fukuhara, A., Yamada, M., Fujimori, K., Kusumoto, T., Nakajima, H., and Inui, T.
- Journal Title
  
  Biochem. J.
  
  Volume: 443巻 Pages: 75-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500428
[Journal Article] Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death.2012
- Author(s)
  Fukuhara, A., Yamada, M., Fujimori, K., Kusumoto, T., Nakajima, H., and Inui, T. (correspondence author)
- Journal Title
  
  Biochem. J.
  
  Volume: 443 巻 Pages: 75-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200076
[Journal Article] An aggregate-prone mutant of human glyceraldehyde-3-phosphate dehydrogenase augments oxidative stress-induced cell death in SH-SY5Y cells.2009
- Author(s)
  Hidemitsu Nakajima, 他
- Journal Title
  
  Biochem.Biophys.Res.Commun 390巻
  
  Pages: 1066-1071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200076
[Journal Article] An aggregate-prone mutant of human glyceraldehyde-3-phosphate dehyd rogenase augments oxidative stress-induced cell death in SH-SY5Y cells.2009
- Author(s)
  Hidemitsu Nakajima, 他
- Journal Title
  
  Biochem.Biophys.Res.Commun. 390巻
  
  Pages: 1066-1071
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500428
[Journal Article] GAPDH aggregate formation participates in oxidative stress-induced cell death.2009
- Author(s)
  Hidemitsu Nakajima, 他
- Journal Title
  
  J.Biol.Chem. 284巻
  
  Pages: 34331-34341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500428
[Journal Article] GAPDH aggregate formation participates in oxidative stress-induced cell death.2009
- Author(s)
  Nakajima, H., Amano, W., Kubo, T., Fukuhara, A., Ihara, H., Azuma, Y., Tajima, H., Inui, T., Sawa, A., and Takeuchi, T.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 284 巻 Pages: 34331-34341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200076
[Journal Article] GAPDH aggregate formation participates in oxidative stress-induced celldeath.2009
- Author(s)
  Hidemitau Nakajima, 他
- Journal Title
  
  J.Biol.Chem. 284
  
  Pages: 34331-34341
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200076
[Journal Article] The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death2007
- Author(s)
  Nakajima H., Amano A., Fujita A., Fukuhara A., Azuma YT., Hata F., Inui T., Takeuchi T.
- Journal Title
  
  J. Biol. Chem. 282(36)
  
  Pages: 26562-26574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580346
[Journal Article] The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death2007
- Author(s)
  Nakajima, H
- Journal Title
  
  J.Biol.Chem 282
  
  Pages: 26562-26574
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19580346
[Patent] GAPDH凝集阻害剤2015
- Inventor(s)
  中嶋秀満
- Industrial Property Rights Holder
  中嶋秀満
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-116140
- Filing Date
  2015-06-08
- Data Source
  KAKENHI-PROJECT-25450428
[Presentation] Contribution of GAPDH nuclear translocation in the hippocampus to depression and anxiety-Like behavior in social stressed mice.2018
- Author(s)
  1.Nakamura S, Kuwamura M, Azuma YT, Takeuchi T, Hikida T, Nakajima H.
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology (WCP2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] 新規メカニズム：GAPDH核移行阻害によるストレス性精神疾患治療薬の探索2017
- Author(s)
  中嶋秀満
- Organizer
  メディカルジャパン2017大阪
- Place of Presentation
  インテックス大阪
- Invited
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] Blockade of GAPDH nuclear translocation in the hippocampus contributes to anti-depressant-like action in stressed mice.2017
- Author(s)
  Hidemitsu Nakajima, Sunao Nakamura, Akinori Kita, Chiho Senami, Mitsuru Kuwamura, Takatoshi Hikida, Yasu-Taka Azuma, and Tadayoshi Takeuchi
- Organizer
  47th annual meeting of the Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] 核移行GAPDHによるストレス性精神疾患発症機序と治療法に関する基盤研究2017
- Author(s)
  板倉正典、中嶋秀満
- Organizer
  Bio Medical Forum 2017/第7回シンポジウム「バイオインターフェース先端マテリアルの創生」・第6回バイオメディカルフォーラム
- Place of Presentation
  あべのメディックス・大阪
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] ストレス性精神疾患モデルにおける海馬GAPDH核移行の病態生理学的意義2017
- Author(s)
  瀬浪千穂、中嶋秀満、東　泰孝、竹内正吉
- Organizer
  第160回日本獣医学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] 多機能性酵素GAPDHのレドックス制御と脳神経疾患-GAPDHを標的とした創薬研究と治療戦略-2017
- Author(s)
  中嶋秀満
- Organizer
  第14回レドックス・ライフイノベーションシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] 多機能性酵素GAPDHの活性中心チオール酸化修飾と脳神経疾患：新規GAPDH凝集阻害薬の創製2017
- Author(s)
  中嶋秀満
- Organizer
  Bio Medical Forum 2017/第7回シンポジウム「バイオインターフェース先端マテリアルの創生」・第6回バイオメディカルフォーラム
- Place of Presentation
  あべのメディックス・大阪
- Invited
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] Pharmacological Strategies to Prevent Injury from Stroke Molecular Factors2016
- Author(s)
  Itakura M, Kubo T, Kaneshige A, Azuma YT, Hikida T, Takeuchi T, Nakajima H.
- Organizer
  46th annual meeting of the Society for Neuroscience
- Place of Presentation
  SanDiego (CA, USA).
- Year and Date
  2016-11-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] Glycelaldehyde-3-phosphate dehydrogenase (GAPDH) aggregates contribute to the pathogenesis of Alzheimer’s disease．2016
- Author(s)
  板倉正典、中嶋秀満、東田周作、瀬見優子、久保岳也、東　泰孝、竹内正吉
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  神奈川県横浜市・パシフィコ横浜会議センター
- Year and Date
  2016-03-10
- Data Source
  KAKENHI-PROJECT-25450428
[Presentation] 細胞外ポリADPリボース(EC-PAR)のグリア細胞株由来神経栄養因子(GDNF)産生に及ぼす影響2016
- Author(s)
  佐藤啓志、中嶋秀満、板倉正典、東　泰孝、竹内正吉
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-15K14857
[Presentation] 細胞外ポリADPリボース（EC-PAR）のグリア細胞株由来神経栄養因子（GDNF）産生機構の解明2016
- Author(s)
  佐藤啓志、中嶋秀満、板倉正典、東　泰孝、竹内正吉
- Organizer
  第159回日本獣医学会学術集会
- Place of Presentation
  藤沢（日本大学）
- Data Source
  KAKENHI-PROJECT-15K14857
[Presentation] GAPDHを基軸としたストレス性精神疾患の発症機序の解明2016
- Author(s)
  北　明讓、東　泰孝、中嶋秀満、竹内正吉
- Organizer
  第159回日本獣医学会学術集会
- Place of Presentation
  藤沢・日本大学
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] 多機能性酵素GAPDHの活性中心チオール酸化修飾と脳神経疾患：創薬標的としての可能性2016
- Author(s)
  中嶋秀満
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台市・東北大学
- Invited
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] GAPDH カスケードを基軸としたストレス性精神疾患の発症機序の解明2016
- Author(s)
  北　明讓、中嶋秀満、東　泰孝、竹内正吉
- Organizer
  第129回日本薬理学会近畿部会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-16H05029
[Presentation] Glyceraldehyde-3-phosphate dehydrogenase aggregation inhibitor: Exploring a drug targeting for Alzheimer’s disease.2015
- Author(s)
  Kita A, Kubo T, Semi Y, Higashida S, Kaneshige A, Itakura M, Azuma YT, Takeuchi T, Nakajima H.
- Organizer
  45th annual meeting of the Society for Neuroscience
- Place of Presentation
  米国イリノイ州シカゴ・McCormick Place
- Year and Date
  2015-10-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450428
[Presentation] Glyceraldehyde-3-phosphate dehydrogenase regulates c-jun N-terminal kinase activation under oxidative stress conditions.2015
- Author(s)
  Sato K, Itakura M, Azuma YT, Takeuchi T, Nakajima H.
- Organizer
  45th annual meeting of the Society for Neuroscience
- Place of Presentation
  米国イリノイ州シカゴ・McCormick Place
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450428
[Presentation] アルツハイマー病の病態形成にGAPDH凝集体が関与する.2015
- Author(s)
  板倉正典、中嶋秀満、東田周作、瀬見優子、久保岳也、東　泰孝、竹内正吉
- Organizer
  第158回日本獣医学会学術集会
- Place of Presentation
  青森県十和田市北里大学
- Year and Date
  2015-09-08
- Data Source
  KAKENHI-PROJECT-25450428
[Presentation] リポカリン型プロスタグランジンD合成酵素による難水溶性抗癌剤SN-38対するドラッグデリバリーシステム2013
- Author(s)
  井上　遥，河野正樹，北出高志，斎藤茉有，中辻匡俊，中嶋秀満，石橋　宰，乾　隆
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25242046
[Presentation] Glyceraldehyde-3-phosphate dehydrogenase act as a seed of alfa-synuclein amyloidogensesis in oxidative stress-induced neurotoxicity both in vitro and in vivo2013
- Author(s)
  Hidemitsu Nakajima, Takeya Kubo, Ayano Fukuhara, Masanori Itakura, Mitsuru Kuwamura, Yasu-Taka Azuma, Takashi Inui, Tadayoshi Takeuchi
- Organizer
  The 11thInternational Conference On Alzheimer's & Parkinson's Diseases
- Place of Presentation
  イタリア、フィレンツェ(ポスター発表
- Year and Date
  2013-03-08
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] Glyceraldehyde-3-phosphate dehydrogenase aggregates accelerates amyloidogensesis of amyloid-β40 and promotes amyloid-・40-induced cell death2013
- Author(s)
  Takeya Kubo, Hidemitsu Nakajima, Yuko Semi, Satoshi Kume, Masanori Itakura,Shusaku Higashida, Mitsuru Kuwamura, Yasu-Taka Azuma, Takashi Inui and Tadayoshi Takeuchi
- Organizer
  The 11thInternational Conference On Alzheimer's & Parkinson's Diseases
- Place of Presentation
  イタリア、フィレンツェ(ポスター発表)
- Year and Date
  2013-03-07
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] ＧＡＰＤＨ凝集阻害による新規アルツハイマー病治療薬の創製2013
- Author(s)
  8.東田周作、久保岳也、板倉正典、中嶋秀満、東　泰孝、竹内正吉
- Organizer
  第123回日本薬理学会近畿部会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25450428
[Presentation] GAPDHペプチドのアミロイド凝集抑制効果2012
- Author(s)
  中嶋秀満
- Organizer
  Bio tech 2012 アカデミックフォーラム
- Place of Presentation
  東京ビッグサイト
- Invited
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] ラットMCAOモデルにおいて、核移行したGAPDHはPARP-1に直接結合し活性化させる2012
- Author(s)
  久保岳也、中嶋秀満、Shahani Neelam、東泰孝、竹内正吉、澤明
- Organizer
  第154回日本獣医学会学術集会
- Place of Presentation
  盛岡(口頭発表)
- Year and Date
  2012-09-15
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] Amyloid-like fibril of GAPDH enhances aggregation and neurotoxicity of a-synuclein2012
- Author(s)
  久保岳也、瀬見優子、中嶋秀満、田島久男、東泰孝、竹内正吉「Amyloid-like fibr
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都(口頭発表)
- Year and Date
  2012-03-14
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] GAPDHペプチドのアミロイド凝集抑制効果2012
- Author(s)
  中嶋秀満
- Organizer
  Bio tech 2012 アカデミックフォーラム
- Place of Presentation
  東京(口頭発表)
- Year and Date
  2012-04-25
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] AccellTMsiRNA のラット側脳室内投与による脳内遺伝子発現のサイレンシング2011
- Author(s)
  久保岳也、中嶋秀満、桑村充、井澤武史、東泰孝、竹内正吉
- Organizer
  第152回日本獣医学会学術集会
- Place of Presentation
  堺(口頭発表)
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] リポカリン蛋白質を用いた難水溶性薬剤に対するドラッグ・デリバリー・システムの開発2011
- Author(s)
  福原彩乃, 中嶋秀満, 宮本優也, 久米慧嗣, 李映昊, 野田勝紀, 内山進, 西村重徳, 大久保忠恭, 後藤祐児, 乾隆
- Organizer
  第11 回日本蛋白質科学会年会
- Place of Presentation
  ホテル阪急エキスポパーク（大阪）
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-21200076
[Presentation] 難水溶性薬物の経口投与におけるリポカリン蛋白質の効果2011
- Author(s)
  福原彩乃, 久米慧嗣, 河野正樹, 人見麻衣, 李映昊, 後藤祐児, 中嶋秀満, 乾隆
- Organizer
  第27回日本DDS学会学術集会
- Place of Presentation
  東京大学本郷キャンパス(東京)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21500428
[Presentation] Drug Delivery System for Poorly Water-soluble Compounds Using Lipocalin Protein.2011
- Author(s)
  Fukuhara, A., Nakajima, H., Miyamoto, Y., Kume, S., Lee, YH., Noda, M., Uchiyama, S., Ohkubo, T., Goto, Y. and Inui, T.
- Organizer
  The 25th Annual Symposium of The Protein Society
- Place of Presentation
  Boston Marriott Copley Place (Boston, USA)
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-21200076
[Presentation] Accell siRNAの単回脳室内投与による脳内の遺伝子サイレンシング効果2011
- Author(s)
  久保岳也、中嶋秀満、瀬見優子、桑村充、井澤武史、東泰孝、竹内正吉
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀(口頭発表)
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] Accel ITM siRNAのラット側脳室内投与による脳内遺伝子発現のサイレンシング2011
- Author(s)
  久保岳也、中嶋秀満、桑村充、井澤武史、東泰孝、竹内正吉
- Organizer
  第152回日本獣医学会学術集会
- Place of Presentation
  大阪府立大学(堺市)
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] GAPDH凝集物はアミロイドβの線維化を促進する2011
- Author(s)
  瀬見優子、中嶋秀満、久保岳也、板倉正典、東泰孝、竹内正吉
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀(口頭発表)
- Year and Date
  2011-09-27
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] 新型siRNAのラット側脳室内単回投与によるin vivo脳内蛋白質ノックダウンの有用性2011
- Author(s)
  久保岳也、中嶋秀満、桑村充、井澤武史、東泰孝、竹内正吉
- Organizer
  第64回日本薬理学会西南部会
- Place of Presentation
  福岡(口頭発表)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] アミロイドβのアミロイド化と細胞死に対するGAPDHアミロイド様線維の増強効果2011
- Author(s)
  瀬見優子、中嶋秀満、久保岳也、板倉正典、東泰孝、竹内正吉
- Organizer
  第64回日本薬理学会西南部会
- Place of Presentation
  福岡(口頭発表)
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] 難水溶性薬物の経口投与におけるリポカリン蛋白質の効果2011
- Author(s)
  福原彩乃, 久米慧嗣, 河野正樹, 人見麻衣, 李映昊, 後藤祐児, 中嶋秀満, 乾隆
- Organizer
  第27回日本DDS 学会学術集会
- Place of Presentation
  東京大学本郷キャンパス (東京)
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-21200076
[Presentation] Accell siRNAの単回脳室内投与による脳内の遺伝子サイレンシング効果2011
- Author(s)
  久保岳也、中嶋秀満、瀬見優子、桑村充、井澤武史、東泰孝、竹内正吉
- Organizer
  第54回日本神経化学会大会
- Place of Presentation
  加賀
- Data Source
  KAKENHI-PROJECT-21380188
[Presentation] GAPDHアミロイド様線維はアミロイドβの凝集を促進する2011
- Author(s)
  瀬見優子、中嶋秀満、久保岳也、板倉正典、東泰孝、竹内正吉
- Organizer
  第152回日本獣医学会学術集会
- Place of Presentation
  堺(口頭発表)
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] 多機能性酵素GAPDHの脳神経疾患における機能的役割と創薬ターゲットとしての可能性2011
- Author(s)
  中嶋秀満
- Organizer
  大阪府立大学メディカルバイオフォーラム
- Place of Presentation
  泉佐野(口頭発表)
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] リポカリン蛋白質を用いた難水溶性薬剤に対するドラッグ・デリバリー・システムの開発2011
- Author(s)
  福原彩乃, 中嶋秀満, 宮本優也, 久米慧嗣, 李映昊, 野田勝紀, 内山進, 西村重徳, 大久保忠恭, 後藤祐児, 乾隆
- Organizer
  第11回日本蛋白質科学会年会
- Place of Presentation
  ホテル阪急エキスポパーク(大阪)
- Year and Date
  2011-06-08
- Data Source
  KAKENHI-PROJECT-21500428
[Presentation] Drug Delivery System for Poorly Water-soluble Compounds Using Lipocalin Protein2011
- Author(s)
  Fukuhara, A., Nakajima, H., Miyamoto, Y., Kume, S., Lee, YH., Noda, M., Uchiyama, S., Ohkubo, T., Goto, Y. and Inui, T.
- Organizer
  The 25th Annual Symposium of The Protein Society
- Place of Presentation
  Boston Marriott Copley Place(Boston, USA)
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-21500428
[Presentation] GAPDHアミロイド様繊維とα-synucleinのクロストークと神経細胞死2010
- Author(s)
  久保岳也、瀬見優子、中嶋秀満、田島久男、東泰孝、竹内正吉
- Organizer
  第150回日本獣医学会学術集会
- Place of Presentation
  帯広(口頭発表)
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] GAPDH凝集特異的ドミナントネガティブ分子による酸化ストレス誘導性神経細胞死の抑制2010
- Author(s)
  久保岳也、中嶋秀満、東泰孝、竹内正吉
- Organizer
  Neuro2010(第33回日本神経科学大会第53回日本神経化学会大会第20回日本神経回路学会大会合同大会)
- Place of Presentation
  神戸(口頭発表)
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] Drug Delivery System for Poorly Water-soluble Drugs by Lipocalin-type Prostaglandin D Synthase2010
- Author(s)
  Fukuhara, A., Nakajima, H., Inoue, K., Miyamoto, Y., Shimamoto, S., Nishimura, S., Ohkubo, T., Takeuchi, T., Inui, T.
- Organizer
  The 24^<th> Annual Symposium of The Protein Society
- Place of Presentation
  California, USA
- Data Source
  KAKENHI-PROJECT-21500428
[Presentation] 多機能性酵素GAPDHの神経細胞死における機能的役割と創薬標的としての可能性2010
- Author(s)
  中嶋秀満
- Organizer
  創薬薬理フォーラム第18回シンポジウム「神経細胞保護」
- Place of Presentation
  東京(口頭発表)
- Year and Date
  2010-02-17
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] GAPDH とASK1 の機能的相互作用2010
- Author(s)
  三崎翔平、中嶋秀満、東泰孝、一條秀憲、竹内正吉
- Organizer
  第118回日本薬理学会近畿部会
- Place of Presentation
  豊中(口頭発表)
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] Drug Delivery System for Poorly Water-soluble Drugs by Lipocalin-type Prostaglandin D Synthase.2010
- Author(s)
  Fukuhara, A., Nakajima, H., Inoue, K., Miyamoto, Y., Shimamoto, S., Nishimura, S., Ohkubo, T., Takeuchi, T., Inui, T.
- Organizer
  The 24^<th> Annual Symposium of The Protein Society
- Place of Presentation
  California, USA
- Data Source
  KAKENHI-PROJECT-21200076
[Presentation] 新規酸化ストレスカスケード:GAPDH-ASK1経路の病態生理学的意義の解明2010
- Author(s)
  三崎翔平、中嶋秀満、東泰孝、竹内正吉
- Organizer
  第150回日本獣医学会学術集会
- Place of Presentation
  帯広(口頭発表)
- Year and Date
  2010-09-16
- Data Source
  KAKENHI-PROJECT-22580339
[Presentation] Protective effect of lipocalin-type prostaglandin D synthase/NBQX complex on neuronal cell death induced by cerebral ischemia2009
- Author(s)
  Fukuhara, A., Nakajima, H., Inoue, K., Miyamoto, Y., Nishimura, S., Yagi, N., Takeuchi, T., Inui, T.
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド（兵庫）
- Data Source
  KAKENHI-PROJECT-21200076
[Presentation] Protective effect of lipocalin-type prostaglandin D synthase on oxidative stress-induced apoptosis in SH-SY5Y cells2009
- Author(s)
  Fukuhara, A., Yamada, M., Kusumoto, T., Nakajima, H., Nishimura, S., and Inui, T.
- Organizer
  VIII European Symposium of The Protein Society
- Place of Presentation
  Zurich, Switzerland
- Data Source
  KAKENHI-PROJECT-21500428
[Presentation] Protective effect of lipocalin-type prostaglandin D synthase on oxidative stress-induced apoptosis in SH-SY5Y cells.2009
- Author(s)
  Fukuhara, A., Yamada, M., Kusumoto, T. Nakajima, H., Nishimura, S., and Inui, T.
- Organizer
  VIII European Symposium of The Protein Society
- Place of Presentation
  Zurich, Switzerland
- Data Source
  KAKENHI-PROJECT-21200076
[Presentation] Protective effect of lipocalin-type prostaglandin D synthase/NBQX complex on neuronal cell death induced by cerebral ischemia2009
- Author(s)
  Fukuhara, A., Nakajima, H., Inoue, K., Miyamoto, Y., Nishimura, S., Yagi, N., Takeuchi, T., Inui, T.
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Data Source
  KAKENHI-PROJECT-21500428
[Presentation] 酸化ストレス誘発性細胞死における核内GAPDHのシグナル伝達経路2008
- Author(s)
  中嶋秀満
- Organizer
  第146回日本獣医学会学術集会
- Place of Presentation
  宮崎市(口頭発表)
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] 酸化ストレスによるGAPDHの核内移行とその役割2008
- Author(s)
  小野葉子、居原秀、中嶋秀満、東泰孝、竹内正吉
- Organizer
  第114回日本薬理学会近畿部会
- Place of Presentation
  神戸(口頭発表)
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] Moonlighting Protein GAPDHによる神経細胞死の分子メカニズム解明〜GAPDHによるアミロイド様凝集の発見と創薬への展望〜2008
- Author(s)
  中嶋秀満
- Organizer
  第145回日本獣医学会学術集会
- Place of Presentation
  相模原市
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] 酸化ストレス誘発性神経細胞死において、核内GAPDHがPARP-1を活性化する2008
- Author(s)
  小野葉子、居原秀、中嶋秀満、東泰孝、竹内正吉
- Organizer
  第51回日本神経化学会大会
- Place of Presentation
  富山(ポスター発表)
- Year and Date
  2008-09-11
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] 酸化ストレス誘発性細胞死における核内GAPDHのシグナル伝達経路2008
- Author(s)
  中嶋秀満、小野葉子、東泰孝、竹内正吉
- Organizer
  第146回日本獣医学会学術集会
- Place of Presentation
  宮崎(口頭発表)
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] Moolighting Protein GAPDHによる神経細胞死の分子メカニズム解明~GAPDHによるアミロイド様凝集の発見と創薬への展望~2008
- Author(s)
  中嶋秀満、東泰孝、竹内正吉
- Organizer
  第145回日本獣医学会学術集会(シンポジウム)
- Place of Presentation
  相模原(口頭発表)
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] 酸化ストレス誘発性神経細胞死におけるヒトGAPDH活性中心システインの重要性2008
- Author(s)
  中嶋秀満、天野渉、東泰孝、竹内正吉
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜(口頭発表)
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] ヒトグリセロアルデヒド3リン酸脱水素酵素の酸化ストレスによるアミロイド様凝集と神経細胞死2007
- Author(s)
  天野渉、中嶋秀満、東泰孝、竹内正吉
- Organizer
  第144回日本獣医学会学術集会
- Place of Presentation
  江別(口頭発表)
- Year and Date
  2007-09-03
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] 酸化ストレスによるグリセロアルデヒド3リン酸脱水素酵素のアミロイド様凝集には活性中心システイン残基が重要である2007
- Author(s)
  中嶋秀満、天野渉、東泰孝、竹内正吉
- Organizer
  第30回日本神経科学大会/第50回日本神経化学会大会/第17回日本神経回路学会大会合同学会
- Place of Presentation
  横浜(口頭発表)
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] 酸化ストレスによるグリセロアルデヒド3リン酸脱水素酵素のアミロイド様凝集には活性中心システイン残基が重要である2007
- Author(s)
  中嶋秀満
- Organizer
  第30回日本神経科学大会/第50回日本神経化学会大会/第17回日本神経回路学会大会合同学会
- Place of Presentation
  横浜市
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] グリセロアルデヒド3リン酸脱水素酵素のアミロイド様凝集と神経細胞死への関与2007
- Author(s)
  天野渉、中嶋秀満、東泰孝、竹内正吉
- Organizer
  第30回日本神経科学大会/第50回日本神経化学会大会/第17回日本神経回路学会大会合同学会
- Place of Presentation
  横浜(ポスター発表)
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] 酸化ストレスによるヒトグリセロアルデヒド3リン酸脱水素酵素のアミロイド様凝集と神経細胞死への関与2007
- Author(s)
  天野渉、中嶋秀満、東泰孝、竹内正吉
- Organizer
  第111回日本薬理学会近畿部会
- Place of Presentation
  名古屋(口頭発表)
- Year and Date
  2007-06-15
- Data Source
  KAKENHI-PROJECT-19580346
[Presentation] Glyceraldehyde-3-phosphate dehydrogenase aggregates acts as a seed of amyloid-β40 amyloidogenesis and enhances the cell death both in vitro and in vivo.
- Author(s)
  Nakajima H., Kubo T., Itakura M., Kaneshige A., Fukuhara A., Azuma Y., Inui T., Takeuchi T.
- Organizer
  26th International Conference of Alzheimer's Association International Conference
- Place of Presentation
  デンマーク / コペンハーゲン
- Year and Date
  2014-07-12 – 2014-07-17
- Data Source
  KAKENHI-PROJECT-25242046

1. INUI Takshi (80352912)

# of Collaborated Projects: 5 results

# of Collaborated Products: 23 results
2. KUWAMURA Mitsuru (20244668)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. FUJITA Akikazu (60282232)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. TAKEUCHI Tadayoshi (00171611)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. KOZAKI Syunji (10109895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MIYAKE Masami (10251175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KATOH Keiko (90252684)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIKIDA Takatoshi (70421378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. YUBA Eiji (80582296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. ISHIBASHI Osamu (70293214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. KATAOKA Yosuke (40291033)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. DOI Hisashi (00421818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Ihara Hideshi (60254447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 東泰孝 (50298816)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 澤智裕 (30284756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 鳩谷晋吾 (40453138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 秋吉秀保 (50420740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. WADA Koichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. YAGI Naoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KIDA Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
21. KADOWAKI Hisae

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 一條秀憲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAKAJIMA Hidemitsu 中嶋 秀満

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最新ゲノム編集法によるネコ型GAPDHノックイン新規アルツハイマー病モデルの開発Principal Investigator

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Regulation of redox signaling by reactive sulfur species in nervous system

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ＧＡＰＤＨカスケードを基軸としたストレス性精神疾患の発症機序解明と治療戦略の構築Principal Investigator

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A neurotrophic role of extracellular poly (ADP-ribose) in neurological sdisorders

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A novel therapeutic target for neurological disoders by inhibition of GAPDH aggregationPrincipal Investigator

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Development of poorly water-soluble drug encapsulated protein nanocapsule possessing cancer directivity and application to DDS

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Research for therapeutic application of dominant negative GAPDH molecule on oxidative stress-induced disorderPrincipal Investigator

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Development of intelligent-type drug delivery system by transporter protein.

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Preclinical study for the therapeutic application of botulinum neurotoxin to intractable brain disorders.

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Development of drug delivery system using intravital transporter protein.

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Role of GAPDH amyloid-like fibrils formation in neurodegenerative diseasesPrincipal Investigator

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[Book] 解糖系酵素glyceraldehyde-3-phosphate dehydrogenase (GAPDH)の多機能性と酸化ストレス性細胞死における役割2010

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[Journal Article] Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo.2017

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NAKAJIMA Hidemitsu 中嶋秀満