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Nito Chikako  仁藤 智香子

ORCIDConnect your ORCID iD *help
… Alternative Names

永田 智香子(仁藤智香子)  ナガタ チカコ

NAGATA Chikako  永田 智香子

NITO Chikako  仁藤 智香子

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Researcher Number 30409172
Other IDs
Affiliation (Current) 2025: 日本医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2021 – 2025: 日本医科大学, 医学部, 教授
2016 – 2020: 日本医科大学, 医学部, 准教授
2015: 日本医科大学, 医学部, 講師
2011 – 2012: 日本医科大学, 医学部, 講師
2010: 日本医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 56010:Neurosurgery-related / Neurosurgery / Neurology
Except Principal Investigator
Basic Section 56010:Neurosurgery-related / Basic Section 90120:Biomaterials-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Neurosurgery
Keywords
Principal Investigator
脳梗塞 / 脳虚血 / 血管新生 / 炎症抑制 / 肝細胞増殖因子 / 局所脳虚血モデル / 幹細胞移植 / 遺伝子治療 / 歯髄幹細胞 / 血液脳関門障害 … More / 局所脳虚血 / 細胞治療 / エクソソーム / 間葉系幹細胞 / 神経細胞保護 / 血液脳関門 / アデノ随伴ウイルスベクター / 脳虚血モデル / 歯髄由来間葉系幹細胞 / 脳保護効果 / AAVベクター / 幹細胞治療 / アデノ随伴ウィルスベクター / 神経細胞死 / Cdk5 … More
Except Principal Investigator
細胞治療 / 脳卒中 / 幹細胞 / ゲノム編集治療 / ウイルス様粒子 / iPS細胞 / 間葉系幹細胞 / ケモカイン / ケモカイン受容体 / ドラッグリポジショニング / 血管性認知症 / 臓器特異的 (脳・骨格筋) / 神経・筋疾患 / 臓器特異的 / ヘテロ核酸 / 核酸医薬 / 感染 / トランスレーショナルリサーチ / 脳梗塞 / 免疫調整 / 幹細胞治療 / 肺炎 / 神経栄養因子 / 神経再生医療 / 神経再生因子 / 頭部外傷 / 脳内出血 / 歯髄由来幹細胞 / 神経保護 / 再生 / 歯髄幹細胞 / ヒストン脱アセチル化酵素阻害剤 / 脳出血 Less
  • Research Projects

    (11 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (14 People)
  •  miRNAを利用した機能強化型間葉系幹細胞による新規脳梗塞治療法の開発Principal Investigator

    • Principal Investigator
      仁藤 智香子
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Nippon Medical School
  •  改変iPS細胞由来間葉系幹細胞を用いた標的化ゲノム編集遺伝子治療法の開発

    • Principal Investigator
      山崎 吉之
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 90120:Biomaterials-related
    • Research Institution
      Nippon Medical School
  •  Development of innovative target organ-specific oligonucleotide therapy

    • Principal Investigator
      永田 哲也
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  ケモカイン受容体デュアル制御分子に着目した血管性認知症に対する疾患修飾薬の確立

    • Principal Investigator
      須田 智
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Saitama Medical University
      Nippon Medical School
  •  羊膜間葉系幹細胞由来エクソソームを利用した次世代型脳梗塞治療法の確立Principal Investigator

    • Principal Investigator
      仁藤 智香子
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Nippon Medical School
  •  重症頭部外傷に対する新規神経栄養因子を用いた再生治療の効率化

    • Principal Investigator
      佐々木 和馬
    • Project Period (FY)
      2019 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Dokkyo Medical University
      Nippon Medical School
  •  Dental pulp-derived stem cell therapy for post-stroke pneumonia: Focusing on intrapulmonary immunity and exploring the possibility of therapeutic application.

    • Principal Investigator
      Suda Satoshi
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Nippon Medical School
  •  Therapeutic gene transfer enhances neuroprotective effects of dental pulp stem cells following focal cerebral ischemia ~ for clinical application ~Principal Investigator

    • Principal Investigator
      Chikako Nito
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Nippon Medical School
  •  Combination therapy with dental pulp stem cells and histone deacetylase inhibitor against intracerebral hemorrhage in rat

    • Principal Investigator
      SUDA SATOSHI
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Nippon Medical School
  •  Effect of Dental Pulp Stem Cells Overexpressing Therapeutic Gene in a Rat Stroke Model.Principal Investigator

    • Principal Investigator
      Nito Chikako
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Nippon Medical School
  •  The role of CDK5 activation in neuronal death and angiogenesis after ischemic strokePrincipal Investigator

    • Principal Investigator
      NAGATA Chikako (NITO Chikako)
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Nippon Medical School

All 2024 2023 2022 2020 2019 2018 2017 2016 2012 2011 2010

All Journal Article Presentation Book

  • [Book] Therapeutic Windowを広げる時間を止める:t-PAと脳保護薬の併用の可能性.分子脳血管病第10巻第1号2010

    • Author(s)
      仁藤智香子、片山泰朗
    • Publisher
      先端医学社
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Journal Article] iPSC-derived mesenchymal stem cells attenuate cerebral ischemia-reperfusion injury by inhibiting inflammatory signaling and oxidative stress2023

    • Author(s)
      Arakawa Masafumi、Sakamoto Yuki、Miyagawa Yoshitaka、Nito Chikako、Takahashi Shiro、Nitahara-Kasahara Yuko、Suda Satoshi、Yamazaki Yoshiyuki、Sakai Mashito、Kimura Kazumi、Okada Takashi
    • Journal Title

      Molecular Therapy - Methods and Clinical Development

      Volume: 30 Pages: 333-349

    • DOI

      10.1016/j.omtm.2023.07.005

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K06921, KAKENHI-PROJECT-22K09268, KAKENHI-PROJECT-23K11857, KAKENHI-PROJECT-21H03828
  • [Journal Article] Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke2022

    • Author(s)
      Nito Chikako、Suda Satoshi、Nitahara-Kasahara Yuko、Okada Takashi、Kimura Kazumi
    • Journal Title

      Biomedicines

      Volume: 10 Issue: 4 Pages: 737-737

    • DOI

      10.3390/biomedicines10040737

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08981, KAKENHI-PROJECT-19K09492, KAKENHI-PROJECT-23K20328
  • [Journal Article] Recent Advances in Cell-Based Therapies for Ischemic Stroke2020

    • Author(s)
      Satoshi Suda, Chikako Nito, Shoji Yokobori, Yuki Sakamoto, Masataka Nakajima, Kota Sowa, Hirofumi Obinata, Kazuma Sasaki, Sean I Savitz, Kazumi Kimura
    • Journal Title

      Int J Mol Sci

      Volume: 21 Issue: 18 Pages: 6718-6718

    • DOI

      10.3390/ijms21186718

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K09492
  • [Journal Article] Impact of Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor after Cerebral Ischemia/Reperfusion in Rats2018

    • Author(s)
      Sowa K, Nito C, Nakajima M, Suda S, Nishiyama Y, Sakamoto Y, Nitahara-Kasahara Y, Nakamura-Takahashi A, Ueda M, Kimura K, Okada T
    • Journal Title

      Mol Ther Methods Clin Dev

      Volume: 10 Pages: 281-290

    • DOI

      10.1016/j.omtm.2018.07.009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K10742, KAKENHI-PROJECT-15K10317, KAKENHI-PROJECT-26293328
  • [Journal Article] Transplantation of human dental pulp stem cells ameliorates brain damage following acute cerebral ischemia2018

    • Author(s)
      Nito C, Sowa K, Nakajima M, Sakamoto Y, Suda S, Nishiyama Y, Nakamura-Takahashi A, Nitahara-Kasahara Y, Ueda M, Okada T, Kimura K
    • Journal Title

      Biomed Pharmacother

      Volume: 108 Pages: 1005-1014

    • DOI

      10.1016/j.biopha.2018.09.084

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10742, KAKENHI-PROJECT-26293328
  • [Journal Article] Involvement of Mitogen-Activated Protein Kinase Pathways in Expression of the Water Channel Protein Aquaporin-4 after Ischemia in Rat Cortical Astrocytes2012

    • Author(s)
      Nito C, Kamada H, Endo H, NarasimhanP, Lee Y-S, Chan PH
    • Journal Title

      J Neurotrauma

      Volume: 29 Pages: 2404-12

    • Data Source
      KAKENHI-PROJECT-22590942
  • [Journal Article] Neuroprotective Effect of an Antioxidant in Ischemic Stroke : Involvement of Neuronal Death Signaling and Blood-brain Barrier Disruption2011

    • Author(s)
      Chikako Nito
    • Journal Title

      J Nippon Med Sch.

      Volume: 78 Pages: 60-62

    • NAID

      130004147093

    • Data Source
      KAKENHI-PROJECT-22590942
  • [Journal Article] FK506 ameliorates oxidative damage and protects rat brain following transient focal cerebral ischemia2011

    • Author(s)
      Nito C, Ueda M, Inaba T, Katsura K, Katayama Y
    • Journal Title

      Neurol Res

      Volume: 33 Pages: 881-9

    • Data Source
      KAKENHI-PROJECT-22590942
  • [Journal Article] FK506 ameliorates oxidative damage and protects rat brain following transient focal cerebral ischemia2011

    • Author(s)
      Chikako Nito
    • Journal Title

      Neurological Research

      Volume: 33 Pages: 881-889

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Journal Article] Neuroprotective Effect of an Antioxidant in Ischemic Stroke: Involvement of Neuronal Death Signaling and Blood-brain Barrier Disruption2011

    • Author(s)
      Nito C, Katayama Y
    • Journal Title

      J Nippon Med Sch

      Volume: 78 Pages: 60-62

    • NAID

      130004147093

    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] 局所脳虚血モデルにおける羊膜由来間葉系幹細胞エクソソームによる脳保護効果の検討2024

    • Author(s)
      髙田慎太郎、仁藤智香子、速水萌々香、端泰雅、髙橋史郎、古寺紘人、澤百合香、木村和美
    • Organizer
      第65回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-21K09163
  • [Presentation] ラット脳虚血モデルにおける羊膜由来間葉系幹細胞投与の脳保護効果2022

    • Author(s)
      3.高橋 史郎, 仁藤 智香子, 荒川 将史, 久保田 麻紗美, 須田 智, 宮川 世志幸, 笠原 優子, 澤 百合香, 酒井 真志人, 岡田 尚巳, 木村 和美
    • Organizer
      第65回 日本脳循環代謝学会学術集
    • Data Source
      KAKENHI-PROJECT-21K09163
  • [Presentation] 脳虚血再灌流障害における羊膜由来間葉系幹細胞移植による脳保護効果の検討2022

    • Author(s)
      5.高橋史郎, 仁藤智香子, 宮川世志幸, 久保田麻沙美, 須田智, 笠原優子, 林真広, 中石智之, 上田恭義, 酒井真志人, 木村和美, 岡田尚巳
    • Organizer
      第28回 日本遺伝子細胞治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K09163
  • [Presentation] 時間で追う脳虚血の病態と治療:(3)慢性期 虚血性脳卒中における歯髄幹細胞をはじめとした細胞治療の展望2019

    • Author(s)
      仁藤智香子
    • Organizer
      日本脳循環代謝学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K10742
  • [Presentation] 歯髄幹細胞移植による新規脳梗塞治療の開発2019

    • Author(s)
      仁藤智香子
    • Organizer
      第44回日本脳卒中学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K10742
  • [Presentation] Neuroprotective effects of human dental pulp stem cells after acute cerebral ischemia.2019

    • Author(s)
      Nito C, Suda S, Sowa K, Nakajima M, Sakamoto Y, Takahashi S, Nishiyama Y, Kasahara YN, Okada T, Kimura K.
    • Organizer
      The 25th Internal Symposium on Cerebral Blood Flow, Metabolism, and Function
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08981
  • [Presentation] 脳卒中におけるトランスレーショナル・リサーチ 歯髄由来幹細胞(DPSC)による虚血性脳卒中の治療法開発2019

    • Author(s)
      仁藤智香子
    • Organizer
      神経治療学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K10742
  • [Presentation] Transplantation of human dental pulp stem cells attenuates brain injury after transient middle cerebral artery occlusion.2019

    • Author(s)
      Nito C, Sowa K, Sakamoto Y, Takahashi S, Arakawa M, Suda S, Nishiyama Y, Takahashi A N, Kasahara YN, Kimura K, Okada T.
    • Organizer
      第25回 日本遺伝子細胞治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08981
  • [Presentation] Effect of dental pulp stem cell overexpressing hepatocyte growth factor by AAV receptor in a rat stroke model.2018

    • Author(s)
      Kota Sowa, Chikako Nito, Masataka Nakajima, Satoshi Suda, Yasuhiro Nishiyama,Aki- Nakamura Takahashi, Yuko Nitahara-Kasahara, Kiwamu Imagawa, Tohru Hirato, Masayuki Ueda, Kazumi Kimura, Takashi Okada
    • Organizer
      The 24th Annual Meeting Japan Society of Gene and Cell Therapy
    • Data Source
      KAKENHI-PROJECT-15K10317
  • [Presentation] Therapeutic Effect of Human Dental Pulp Stem Cells Overexpressing Hepatocyte Growth Factor in Experimental Stroke2018

    • Author(s)
      Kota Sowa, Chikako Nito, Masataka Nakajima, Satoshi Suda, Yasuhiro Nishiyama, Aki Takahashi, Yuko Kasahara, Kiwamu Imagawa, Tohru Hirato, Masayuki Ueda, Takashi Okada, Kazumi Kimura
    • Organizer
      International Stroke Conference 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K10317
  • [Presentation] Transplantation of dental pulp stem cells ameliorates brain damage after focal cerebral ischemia2017

    • Author(s)
      仁藤智香子
    • Organizer
      第57回日本神経学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K10742
  • [Presentation] ラット局所脳虚血モデルにおけるHGF強発現歯髄幹細胞移植の神経保護効果2017

    • Author(s)
      岨 康太,仁藤智香子, 中島壯崇, 須田 智, 上田雅之, 笠原優子, 今川 究, 平戸徹,岡田尚巳, 木村和美
    • Organizer
      第42回日本脳卒中学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2017-03-16
    • Data Source
      KAKENHI-PROJECT-16K10742
  • [Presentation] 虚血再灌流障害における歯髄幹細胞移植の神経保護効果2016

    • Author(s)
      仁藤智香子、岨康太、中島壯崇、須田智、岡田尚巳、木村和美
    • Organizer
      第59回 日本脳循環代謝学会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-15K10317
  • [Presentation] ラット局所脳虚血モデルにおけるHGF強発現歯髄幹細胞移植の治療効果2016

    • Author(s)
      岨康太、仁藤智香子、中島壯崇、須田智、岡田尚巳、木村和美
    • Organizer
      第59回 日本脳循環代謝学会
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-15K10317
  • [Presentation] The neuroprotective effects of Post-treatment with atorvastatin reduces inflammatory responses and protects rat brain after transient focal ischemia2012

    • Author(s)
      Saito T, Nito C, Ueda M, Inaba T, Kamiya F, Katayama Y
    • Organizer
      42nd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] Neuroprotective effects of nicergoline against brain damage in a rat model of permanent focal cerebral ischemia2012

    • Author(s)
      Nito C, Inaba T, Ueda M, Saito T, Katayama Y
    • Organizer
      42nd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] Combination therapy with edaravone and mild hypothermia prevents MMP-9activiation and neurovascular injury after focal cerebral ischemia in rats2011

    • Author(s)
      Nito C, Ueda M, Inaba T, Okubo S, Nomur K, Kamiya F, Ohta S, Katayama Y
    • Organizer
      The 25th Internal Symposium on Cerebral Blood Flow, Metabolism, and Function
    • Place of Presentation
      Barcelona, Spain
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] Combination therapy with edaravone and mild hypothermia prevents MMP-9 activiation and neurovascular injury after focal cerebral ischemia in rats2011

    • Author(s)
      Chikako Nito
    • Organizer
      The 25th Internal Symposium on Cerebral Blood Flow, Metabolism, and Function
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2011-05-15
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] A free radical scavenger combined with mild hypothermia attenuates ischemic brain damage by suppressing matrix metalloproteinase 92011

    • Author(s)
      Chikako Nito
    • Organizer
      The 5th Korean-Japanese Joint Stroke Conference
    • Place of Presentation
      Gyeongju, Korea
    • Year and Date
      2011-10-15
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] A free radical scavenger and mild hypothemia for brain damage after focal ischemeia-Effects on MMP activation and blood-brain barrier disruption2010

    • Author(s)
      Chikako Nito-Nagata
    • Organizer
      The 1st Forum on Cerebral Blood Flow, Metabolism and Function Kyoto 2010
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-10-15
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] A free radical scavenger combined with mild hypothermia attenuates ischemic brain damage by suppressing matrix metalloproteinase 92010

    • Author(s)
      Nito C, Ueda M, Inaba T, Nomura K, Katayama Y
    • Organizer
      40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Data Source
      KAKENHI-PROJECT-22590942
  • [Presentation] A free radical scavenger combined with mild hypothermia ameriolates ischemic brain damage by suppressing matrix metalloproteinase 92010

    • Author(s)
      Chikako Nito
    • Organizer
      40th Annual Meeting of Neuroscience
    • Place of Presentation
      Chicago, U.S.A.
    • Year and Date
      2010-11-15
    • Data Source
      KAKENHI-PROJECT-22590942
  • 1.  SUDA SATOSHI (00366733)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 13 results
  • 2.  横堀 将司 (70449271)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  永田 哲也 (50362976)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  宮川 世志幸 (90415604)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  佐々木 和馬 (30832266)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  山田 真吏奈 (70508621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  阪本 太吾 (90587073)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  神尾 孝一郎 (20465305)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  原 倫太朗 (70709766)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  笠原 優子 (90391911)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 11.  寺島 裕也 (90538729)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  山崎 吉之 (90407685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  Okada Takashi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 14.  YOKOBORI Shouji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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