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HARA RINTARO  原 倫太朗

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Rintaro Hara  原 倫太朗

Hara Rintaro  原 倫太朗

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Researcher Number 70709766
Other IDs
Affiliation (Current) 2025: 東京科学大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 講師
2023 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 特任講師
2019 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト講師
2016 – 2017: 東京理科大学, 薬学部生命創薬科学科, 助教
2015: 東京理科大学, 薬学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 90120:Biomaterials-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Bio-related chemistry
Except Principal Investigator
Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 52020:Neurology-related / Basic Section 54010:Hematology and medical oncology-related
Keywords
Principal Investigator
核酸医薬 / RNase H / glymphatic system / ペプチド / A型核酸二本鎖 / 人工カチオン性分子(ACM) / ヘテロ二本鎖核酸(HDO) / アンチセンス核酸(ASO) / メジャーグルーブ / 人工カチオン性分子 … More / アンチセンス核酸 / DNA-templated synthesis / 水中での化学反応 / ミスマッチ識別 / DNA/RNA二本鎖 / カチオン性オリゴペプチド / カチオン性オリゴ糖 / スクリーニング / リボヌクレアーゼH(RNase H) / アンチセンス核酸医薬 … More
Except Principal Investigator
核酸医薬 / アンチセンス核酸 / ヘテロ核酸 / グリオーシス / マイクロRNA / EBウイルス / 臓器特異的 (脳・骨格筋) / 神経・筋疾患 / 臓器特異的 / スキッピング / カヘキシア / エクソン・スキッピング / 筋疾患 / 脂質リガンド / 遺伝性筋疾患 / 骨格筋 / 心筋 Less
  • Research Projects

    (7 results)
  • Research Products

    (11 results)
  • Co-Researchers

    (11 People)
  •  脳移行促進能と核酸結合能を併せ持つ分子を用いた核酸医薬の脳内デリバリー法の開発Principal Investigator

    • Principal Investigator
      原 倫太朗
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 90120:Biomaterials-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of a treatment for chronic active EB virus infection targeting virus-derived microRNAs

    • Principal Investigator
      新井 文子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      St. Marianna University School of Medicine
  •  Development of innovative target organ-specific oligonucleotide therapy

    • Principal Investigator
      永田 哲也
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  グリオーシス回避を可能とする2本鎖核酸医薬の開発

    • Principal Investigator
      吉岡 耕太郎
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of innovative nucleic acid therapy enabling any gene control in cardiac and skeletal muscle

    • Principal Investigator
      Nagata Tetsuya
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 47:Pharmaceutical sciences and related fields
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of artificial cationic caionic molecules-conjugated oligonucleotides for high efficacy and low toxicityPrincipal Investigator

    • Principal Investigator
      Rintaro Hara
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of high-throughput screening methods for antisense oligonucleotidesPrincipal Investigator

    • Principal Investigator
      Hara Rintaro
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Bio-related chemistry
    • Research Institution
      Tokyo University of Science

All 2021 2019 2018 2016 2015

All Journal Article Presentation Patent

  • [Journal Article] Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide2021

    • Author(s)
      Rintaro Iwata Hara, Takeshi Wada
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 19 Issue: 31 Pages: 6865-6870

    • DOI

      10.1039/d1ob00983d

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06993, KAKENHI-PROJECT-23K21353
  • [Journal Article] DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo2021

    • Author(s)
      Ohyagi Masaki、Nagata Tetsuya、Ihara Kensuke、Yoshida-Tanaka Kie、Nishi Rieko、Miyata Haruka、Abe Aya、Mabuchi Yo、Akazawa Chihiro、Yokota Takanori
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 7344-7344

    • DOI

      10.1038/s41467-021-26902-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-21H03328, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
  • [Journal Article] Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.2021

    • Author(s)
      Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T
    • Journal Title

      Nat Biotechnol

      Volume: 39 Issue: 12 Pages: 1529-1536

    • DOI

      10.1038/s41587-021-00972-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-23K21353, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
  • [Journal Article] Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs2018

    • Author(s)
      Rintaro Iwata Hara, Yuki Hisada, Yusuke Maeda, Takanori Yokota, Takeshi Wada
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 4323-4323

    • DOI

      10.1038/s41598-018-22161-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15K17886, KAKENHI-PROJECT-15H03839
  • [Patent] 核酸医薬副作用軽減剤、該核酸医薬副作用軽減剤を含む医薬組成物、並びに核酸医薬の副作用惹起性を軽減する方法2019

    • Inventor(s)
      原倫太朗 他7名
    • Industrial Property Rights Holder
      原倫太朗 他7名
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-120908
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-19K06993
  • [Patent] RNAハイブリッド形成用核酸オリゴマー2016

    • Inventor(s)
      和田猛、吉野怜次郎、額賀陽平、原倫太朗
    • Industrial Property Rights Holder
      和田猛、吉野怜次郎、額賀陽平、原倫太朗
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-046181
    • Filing Date
      2016-03-09
    • Data Source
      KAKENHI-PROJECT-15K17886
  • [Presentation] 人工カチオン性ペプチドによるヘテロ二本鎖核酸の機能制御2019

    • Author(s)
      高木一憲、大原正裕、吉田規恵、前田雄介、原倫太朗、佐藤一樹、永田哲也、横田隆徳、和田猛
    • Organizer
      日本核酸医薬学会 第5回年会
    • Data Source
      KAKENHI-PROJECT-19K06993
  • [Presentation] Improvement of single mismatch discrimination in RNase H cleavage by artificial cationic oligosaccharides2018

    • Author(s)
      Rintaro Hara, Takeshi Wada
    • Organizer
      日本化学会第98春季年会
    • Data Source
      KAKENHI-PROJECT-15K17886
  • [Presentation] Synthesis and properties of L-2,4-diaminobutyric acid (Dab) oligomer-conjugated antisense oligonucleotides2018

    • Author(s)
      Taku Suenaga, Yusuke Maeda, Rintaro Hara, Takeshi Wada
    • Organizer
      日本化学会第98春季年会
    • Data Source
      KAKENHI-PROJECT-15K17886
  • [Presentation] Artificial cationic oligosaccharides as carriers for nucleic acid drugs2015

    • Author(s)
      Rintaro Iwata, Yusuke Maeda, Taiichi Sakamoto, Takeshi Wada
    • Organizer
      The 42nd International Symposium on Nucleic Acids Chemistry
    • Place of Presentation
      イーグレ姫路()
    • Year and Date
      2015-09-23
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K17886
  • [Presentation] RNA duplex binding molecules as carriers for siRNA2015

    • Author(s)
      Rintaro Iwata, Futoshi Nakayama, Sakie Hirochi, Kazuki Sato, Yusuke Maeda, Wenying Piao, Kazutaka Nishina, Takanori Yokota, Takeshi Wada
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015
    • Place of Presentation
      Sheraton Waikiki (Honolulu, Hawaii, USA)
    • Year and Date
      2015-12-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K17886
  • 1.  吉岡 耕太郎 (70780641)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 2.  Nagata Tetsuya (50362976)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  横田 隆徳 (90231688)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  仁藤 智香子 (30409172)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  新井 文子 (70359678)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  西尾 美和子 (30623318)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  桑原 宏哉 (80723486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YOSHIDA Mari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  井原 健介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  内原 俊記
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  和田 猛
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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