HARA RINTARO 原倫太朗

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Rintaro Hara 原倫太朗

Hara Rintaro 原倫太朗

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Researcher Number	70709766
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help	2024: 東京医科歯科大学, 大学院医歯学総合研究科, 講師 2023 – 2024: 東京医科歯科大学, 大学院医歯学総合研究科, 特任講師 2019 – 2022: 東京医科歯科大学, 大学院医歯学総合研究科, プロジェクト講師 2016 – 2017: 東京理科大学, 薬学部生命創薬科学科, 助教 2015: 東京理科大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Bio-related chemistry Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 52020:Neurology-related / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 核酸医薬 / RNase H / glymphatic system / ペプチド / A型核酸二本鎖 / 人工カチオン性分子（ACM） / ヘテロ二本鎖核酸（HDO） / アンチセンス核酸（ASO） / メジャーグルーブ / 人工カチオン性分子 … More / アンチセンス核酸 / DNA-templated synthesis / 水中での化学反応 / ミスマッチ識別 / DNA/RNA二本鎖 / カチオン性オリゴペプチド / カチオン性オリゴ糖 / スクリーニング / リボヌクレアーゼH（RNase H） / アンチセンス核酸医薬 … More Except Principal Investigator 核酸医薬 / アンチセンス核酸 / ヘテロ核酸 / グリオーシス / マイクロRNA / EBウイルス / 臓器特異的 (脳・骨格筋) / 神経・筋疾患 / 臓器特異的 / スキッピング / カヘキシア / エクソン・スキッピング / 筋疾患 / 脂質リガンド / 遺伝性筋疾患 / 骨格筋 / 心筋 Less

脳移行促進能と核酸結合能を併せ持つ分子を用いた核酸医薬の脳内デリバリー法の開発Principal Investigator
- Principal Investigator
  
  原倫太朗
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Medical and Dental University
Development of a treatment for chronic active EB virus infection targeting virus-derived microRNAs
- Principal Investigator
  
  新井文子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  St. Marianna University School of Medicine
Development of innovative target organ-specific oligonucleotide therapy
- Principal Investigator
  
  永田哲也
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tokyo Medical and Dental University
グリオーシス回避を可能とする2本鎖核酸医薬の開発
- Principal Investigator
  
  吉岡耕太郎
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tokyo Medical and Dental University
Development of innovative nucleic acid therapy enabling any gene control in cardiac and skeletal muscle
- Principal Investigator
  
  Nagata Tetsuya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Tokyo Medical and Dental University
Development of artificial cationic caionic molecules-conjugated oligonucleotides for high efficacy and low toxicityPrincipal Investigator
- Principal Investigator
  
  Rintaro Hara
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Tokyo Medical and Dental University
Development of high-throughput screening methods for antisense oligonucleotidesPrincipal Investigator
- Principal Investigator
  
  Hara Rintaro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bio-related chemistry
- Research Institution
  Tokyo University of Science

All 2021 2019 2018 2016 2015

All Journal Article Presentation Patent

[Journal Article] Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide2021
- Author(s)
  Rintaro Iwata Hara, Takeshi Wada
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 19 Issue: 31 Pages: 6865-6870
- DOI
  10.1039/d1ob00983d
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06993, KAKENHI-PROJECT-23K21353
[Journal Article] DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo2021
- Author(s)
  Ohyagi Masaki、Nagata Tetsuya、Ihara Kensuke、Yoshida-Tanaka Kie、Nishi Rieko、Miyata Haruka、Abe Aya、Mabuchi Yo、Akazawa Chihiro、Yokota Takanori
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 7344-7344
- DOI
  10.1038/s41467-021-26902-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-21H03328, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
[Journal Article] Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.2021
- Author(s)
  Nagata T, Dwyer CA, Yoshida-Tanaka K, Ihara K, Ohyagi M, Kaburagi H, Miyata H, Ebihara S, Yoshioka K, Ishii T, Miyata K, Miyata K, Powers B, Igari T, Yamamoto S, Arimura N, Hirabayashi H, Uchihara T, Hara RI, Wada T, Bennett CF, Seth PP, Rigo F, Yokota T
- Journal Title
  
  Nat Biotechnol
  
  Volume: 39 Issue: 12 Pages: 1529-1536
- DOI
  10.1038/s41587-021-00972-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03555, KAKENHI-PROJECT-21H02909, KAKENHI-PROJECT-23K21353, KAKENHI-PROJECT-17H06109, KAKENHI-PROJECT-19H01016
[Journal Article] Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs2018
- Author(s)
  Rintaro Iwata Hara, Yuki Hisada, Yusuke Maeda, Takanori Yokota, Takeshi Wada
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 4323-4323
- DOI
  10.1038/s41598-018-22161-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08933, KAKENHI-PROJECT-15K17886, KAKENHI-PROJECT-15H03839
[Patent] 核酸医薬副作用軽減剤、該核酸医薬副作用軽減剤を含む医薬組成物、並びに核酸医薬の副作用惹起性を軽減する方法2019
- Inventor(s)
  原倫太朗　他７名
- Industrial Property Rights Holder
  原倫太朗　他７名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2019-120908
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-19K06993
[Patent] RNAハイブリッド形成用核酸オリゴマー2016
- Inventor(s)
  和田猛、吉野怜次郎、額賀陽平、原倫太朗
- Industrial Property Rights Holder
  和田猛、吉野怜次郎、額賀陽平、原倫太朗
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-046181
- Filing Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-15K17886
[Presentation] 人工カチオン性ペプチドによるヘテロ二本鎖核酸の機能制御2019
- Author(s)
  高木一憲、大原正裕、吉田規恵、前田雄介、原倫太朗、佐藤一樹、永田哲也、横田隆徳、和田猛
- Organizer
  日本核酸医薬学会　第５回年会
- Data Source
  KAKENHI-PROJECT-19K06993
[Presentation] Improvement of single mismatch discrimination in RNase H cleavage by artificial cationic oligosaccharides2018
- Author(s)
  Rintaro Hara, Takeshi Wada
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-15K17886
[Presentation] Synthesis and properties of L-2,4-diaminobutyric acid (Dab) oligomer-conjugated antisense oligonucleotides2018
- Author(s)
  Taku Suenaga, Yusuke Maeda, Rintaro Hara, Takeshi Wada
- Organizer
  日本化学会第98春季年会
- Data Source
  KAKENHI-PROJECT-15K17886
[Presentation] Artificial cationic oligosaccharides as carriers for nucleic acid drugs2015
- Author(s)
  Rintaro Iwata, Yusuke Maeda, Taiichi Sakamoto, Takeshi Wada
- Organizer
  The 42nd International Symposium on Nucleic Acids Chemistry
- Place of Presentation
  イーグレ姫路（）
- Year and Date
  2015-09-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K17886
[Presentation] RNA duplex binding molecules as carriers for siRNA2015
- Author(s)
  Rintaro Iwata, Futoshi Nakayama, Sakie Hirochi, Kazuki Sato, Yusuke Maeda, Wenying Piao, Kazutaka Nishina, Takanori Yokota, Takeshi Wada
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015
- Place of Presentation
  Sheraton Waikiki (Honolulu, Hawaii, USA)
- Year and Date
  2015-12-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K17886

1. 吉岡耕太郎 (70780641)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Nagata Tetsuya (50362976)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 横田隆徳 (90231688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 仁藤智香子 (30409172)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 新井文子 (70359678)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 西尾美和子 (30623318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 桑原宏哉 (80723486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOSHIDA Mari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 井原健介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 内原俊記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 和田猛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARA RINTARO 原 倫太朗

Rintaro Hara 原 倫太朗

Hara Rintaro 原 倫太朗

Research Projects

Research Products

Co-Researchers

脳移行促進能と核酸結合能を併せ持つ分子を用いた核酸医薬の脳内デリバリー法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a treatment for chronic active EB virus infection targeting virus-derived microRNAs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative target organ-specific oligonucleotide therapy

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グリオーシス回避を可能とする2本鎖核酸医薬の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative nucleic acid therapy enabling any gene control in cardiac and skeletal muscle

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of artificial cationic caionic molecules-conjugated oligonucleotides for high efficacy and low toxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of high-throughput screening methods for antisense oligonucleotidesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Inhibition of off-target cleavage by RNase H using an artificial cationic oligosaccharide2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DNA/RNA heteroduplex oligonucleotide technology for regulating lymphocytes in vivo2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood-brain barrier and knock down genes in the rodent CNS.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Artificial cationic oligosaccharides for heteroduplex oligonucleotide-type drugs2018

Author(s)

Journal Title

DOI

Data Source

[Patent] 核酸医薬副作用軽減剤、該核酸医薬副作用軽減剤を含む医薬組成物、並びに核酸医薬の副作用惹起性を軽減する方法2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

Filing Date

Data Source

[Patent] RNAハイブリッド形成用核酸オリゴマー2016

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Industrial Property Number

HARA RINTARO 原倫太朗

Rintaro Hara 原倫太朗

Hara Rintaro 原倫太朗