Okamoto Takeshi 岡本健

… Alternative Names

岡本健オカモトタケシ

OKAMOTO Takeshi 岡本健

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Researcher Number	30414113
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2020: 京都大学, 医学研究科, 准教授 2016 – 2018: 京都大学, 医学研究科, 准教授 2015: 京都大学, 医学(系)研究科(研究院), 准教授 2013 – 2014: 京都大学, 医学(系)研究科(研究院), 講師 2012: 京都大学, 医学研究科, 助教 2011 – 2012: 京都大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator トランスクリプトーム解析 / エピゲノム解析 / 人工多能性幹細胞 / 遺伝子変異 / イソクエン酸デヒドロゲナーゼ / isocitrate dehydorgenase / 軟骨形成腫瘍 / oncometabolite / 細胞・組織 / マイクロアレイ … More Except Principal Investigator … More 骨軟部肉腫 / 整形外科 / ゲノム / 癌 / 融合遺伝子 / 骨軟部腫瘍 / がんゲノム / ゲノム解析 / 肉腫 / 軟骨形成腫瘍 / ヒストンメチル化 / 神経幹細胞 / 間葉系幹細胞 / 軟骨腫瘍 / iPS細胞 / 軟骨形成性腫瘍 / IDH遺伝子 / p16 / iPSC / IDH / chondrosarcoma Less

Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
- Principal Investigator
  
  Matsuda Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Investigation of functional roles of mutant IDH as specific mutations in cartilage-forming tumors and its application for the development of treatment
- Principal Investigator
  
  Toguchida Junya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University
The research on the contribution of mutant IDH gene to the formation of cartilagenous tumorsPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Takeshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University
Evaluation of mechanism of ossification of the posterior longitudinal ligament and identification of candidate disease gene associated with ossification of the posterior longitudinal ligamentPrincipal Investigator
- Principal Investigator
  
  OKAMOTO Takeshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University

All 2016 2015 2014

All Journal Article Presentation

[Journal Article] SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier.2015
- Author(s)
  Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, Hineno S, Okamoto T, Watanabe M, Woltjen K, Ikeya M, Kato T Jr, Toguchida J.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 11 Pages: e0142991-e0142991
- DOI
  10.1371/journal.pone.0142991
- NAID
  120005749920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04956
[Journal Article] Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.2015
- Author(s)
  Jin Y, Elalaf H, Watanabe M, Tamaki S, Hineno S, Matsunaga K, Woltjen K, Kobayashi Y, Nagata S, Ikeya M, Kato T Jr, Okamoto T, Matsuda S, Toguchida J.
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 7 Pages: e0131998-e0131998
- DOI
  10.1371/journal.pone.0131998
- NAID
  120005756272
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04956
[Journal Article] Screening of BCOR-CCNB3 sarcoma using immunohistochemistry for CCNB3: A clinicopathological report of three pediatric cases.2015
- Author(s)
  Shibayama T, Okamoto T, Nakashima Y, Kato T, Sakurai T, Minamiguchi S, Kataoka TR, Shibuya S, Yoshizawa A, Toguchida J, Haga H.
- Journal Title
  
  Pathol Int
  
  Volume: 65 Issue: 8 Pages: 410-414
- DOI
  10.1111/pin.12319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] D-2-HG産生を伴うIDH1/2変異が及ぼす骨・軟骨分化への影響2016
- Author(s)
  鎌倉武史、金永輝、渡辺真、岡本健史、吉富啓之、戸口田淳也
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] 葉系幹細胞の分化及び形質転換に対するD-2-HG産生型変異IDH1の作用2016
- Author(s)
  鎌倉武史、金永輝、渡辺真、松永一仁、玉置さくら、岡本健史、吉富啓之、戸口田淳也
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] Mutant IDH1 dysregulates the differentiation of mesenchymal stem cells in association with gene-specific histone modifications to cartilage- and bone-related genes.2016
- Author(s)
  Jin, Y., Watanabe, M., Tamaki, S., Okamoto, T., and Toguchida, J. Mutant IDH1
- Organizer
  CTOS 21th Annual Meeting
- Place of Presentation
  Lisbon（Portugal）
- Year and Date
  2016-11-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] 多能性幹細胞の肉腫研究への応用2016
- Author(s)
  戸口田淳也、玉置さくら、関口和也、金永輝、岡本健、松田秀一
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-05-12
- Invited
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] 変異型IDH1は遺伝子特異的なヒストン修飾を介して、間葉系幹細胞から軟骨及び骨への分化を脱制御する2016
- Author(s)
  金永輝、Hassan Elalaf、渡辺真、玉置さくら、日根野翔、松永一仁、Knut Woltjen,　岡本健、松田秀一、戸口田淳也
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] EXPLORATION OF CANDIDATE GENES TO INDUCE CARTILAGE TUMORS WITH MUTANT IDH1 GENE USING IPSC2016
- Author(s)
  Kamakura, T., Jin, Y., Matsunaga, K., Watanabe, M., Tamaki, S., Okamoto, T., Yoshitomi, H., Toguchida, J
- Organizer
  CTOS 2016 Annual Meeting
- Place of Presentation
  Lisbon（Portugal）
- Year and Date
  2016-11-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] Mutant IDH1 desregulates the differentiation property of human mesenchymal stem cells through gene-specific epigenetic modification2015
- Author(s)
  Toguchida J, Jin Y, Watanabe M, Okamoto T
- Organizer
  第20回CTOS
- Place of Presentation
  Salt Lake City（USA）
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] 変異型IDH1は骨・軟骨関連遺伝子のヒストンを遺伝子特異的に修飾し、間葉系幹細胞の分化能を脱制御する2015
- Author(s)
  金永輝、Hassan Elalaf、渡辺真、玉置さくら、日根野翔、松永一仁、Knut Woltjen、岡本健、松田秀一、戸口田淳也
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] SS18-SSX, the oncogenic fusion protein in synvival sarcoma, is a cellular context-dependent epigenetic modifier2015
- Author(s)
  Tamaki S, Fukuta M, Sekiguchi K, Hayakawa K, Jin Y, Hineno S, Okamoto T, Watanbe M, Woltjen K, Ikeya M, Kato T, Toguchida J
- Organizer
  第20回CTOS
- Place of Presentation
  Salt Lake City（USA）
- Year and Date
  2015-11-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] 間葉系幹細胞の骨軟骨分化能における変異型IDH1の影響2015
- Author(s)
  岡本健、金永輝、玉置さくら、松田秀一、戸口田淳也
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2015-10-31
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] 間葉系幹細胞の骨分化能における変異型IDH1の影響2015
- Author(s)
  金永輝、Hassan Elalaf、渡辺真、玉置さくら、日根野翔、松永一仁、Knut Woltjen、岡本健、松田秀一、戸口田淳也
- Organizer
  第48回日本整形外科学会骨軟部腫瘍学術集会
- Place of Presentation
  かがわ国際会議場（香川県高松市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] BCOR-CCNB3融合遺伝子陽性のEwing-like sarcomaの治療経験2015
- Author(s)
  朴憲之、岡本健、仲俣岳晴、中山富貴、松田秀一、戸口田淳也
- Organizer
  第48回日本整形外科学会骨軟部腫瘍学術集会
- Place of Presentation
  かがわ国際会議場（香川県高松市）
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15H04956
[Presentation] Mutant IDH promotes chondrogenic, but impairs osteogenic differentiation of human mesenchymal stem cells through epigenetic modulation2014
- Author(s)
  Youghui Jin, Hassan Elalaf, Makoto Watanabe, Kazuhito Matsunaga, Tomohisa Kato, Takeshi Okamoto, Shuichi Matsuda, Junya Toguchida
- Organizer
  第４７回日本整形外科学会　骨・軟部腫瘍学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-07-17
- Data Source
  KAKENHI-PROJECT-25670642

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Okamoto Takeshi 岡本 健

岡本 健 オカモト タケシ

OKAMOTO Takeshi 岡本 健

Research Projects

Research Products

Co-Researchers

Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of functional roles of mutant IDH as specific mutations in cartilage-forming tumors and its application for the development of treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The research on the contribution of mutant IDH gene to the formation of cartilagenous tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Evaluation of mechanism of ossification of the posterior longitudinal ligament and identification of candidate disease gene associated with ossification of the posterior longitudinal ligamentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Screening of BCOR-CCNB3 sarcoma using immunohistochemistry for CCNB3: A clinicopathological report of three pediatric cases.2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] D-2-HG産生を伴うIDH1/2変異が及ぼす骨・軟骨分化への影響2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 葉系幹細胞の分化及び形質転換に対するD-2-HG産生型変異IDH1の作用2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Mutant IDH1 dysregulates the differentiation of mesenchymal stem cells in association with gene-specific histone modifications to cartilage- and bone-related genes.2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 多能性幹細胞の肉腫研究への応用2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 変異型IDH1は遺伝子特異的なヒストン修飾を介して、間葉系幹細胞から軟骨及び骨への分化を脱制御する2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] EXPLORATION OF CANDIDATE GENES TO INDUCE CARTILAGE TUMORS WITH MUTANT IDH1 GENE USING IPSC2016

Author(s)

Organizer

Okamoto Takeshi 岡本健

岡本健オカモトタケシ

OKAMOTO Takeshi 岡本健