Horiuchi Keisuke 堀内圭輔

… Alternative Names

HORIUCHI Keisuke 堀内圭輔

堀内圭輔ホリウチケイスケ

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Researcher Number	30327564
Other IDs	https://orcid.org/0000-0001-7063-9609
Affiliation (Current)	2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 整形外科学, 教授
Affiliation (based on the past Project Information) *help	2024: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 整形外科学, 准教授 2023: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 整形外科学, 教授 2019 – 2022: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 整形外科学, 准教授 2017 – 2018: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 整形外科学, 講師 2016: 慶應義塾大学, 医学部(信濃町), 特任准教授 … More 2016: 慶應義塾大学, 医学部(信濃町), 講師 2014 – 2015: 慶應義塾大学, 医学部, 准教授 2013 – 2015: 慶應義塾大学, 医学部, 特任准教授 2012: 慶應義塾大学, 医学部, 講師 2011 – 2012: 慶應義塾大学, 医学部, 特任講師 2011: 慶應義塾大学, 医学部, 特任准教授 2007 – 2010: Keio University, 医学部, 講師 2001: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related Except Principal Investigator Orthopaedic surgery / Basic Section 56020:Orthopedics-related / Orthopaedic surgery
Keywords	Principal Investigator 骨代謝 / TACE/ADAM10 / TACE / ADAM17 / 骨格筋変性 / 間葉系前駆細胞 / IL-33 / サルコペニア / 骨格筋萎縮 / 線維化 … More / 脂肪変性 / 筋再生 / 加齢 / fibroadipose progenitor / レチノイン酸受容体 / 筋線維化 / 筋脂肪変性 / 未分化間葉系細胞 / 筋衛星細胞 / 筋萎縮 / 骨格筋脂肪変性 / 骨格筋 / 造血制御 / 小胞体ストレス応答 / ADAM10 / 小胞体ストレス / ADAM遺伝子 / 筋代謝 / 骨軟骨代謝 / 血液幹細胞 / 軟骨代謝学 / 骨 / CSF-1 / 炎症 / Ectodomain Shedding / 骨代謝学 / 免疫学 / 骨・軟骨代謝学 … More Except Principal Investigator Notch / エネルギー代謝 / 思春期特発性側弯症 / LBX1 / ATDC5 / 発生・分化 / シグナル伝達 / シェディング / ADAM10 / Mkx / 老化 / 間葉系幹細胞 / 骨化 / LBX1遺伝子 / 表現型解析 / 側弯症 / 糖耐能 / 後弯変形 / 思春期突発性側弯症 / マウスモデル / 脊柱変形 / 脊椎 / 炎症 / 変性 / 黄色靭帯 / 腰部脊柱管狭窄症 / 椎間板 / 髄核 / 慢性炎症 / ヒアルロン酸 / 椎間板変性 / 遺伝子解析 / プロテオーム解析 / 分子標的薬 / 化学療法 / オミクス研究 / 分子標的治療 / 軟部肉腫 / 希少がん / 骨軟部肉腫 / 整形外科 / ゲノム / 癌 / 融合遺伝子 / 骨軟部腫瘍 / がんゲノム / ゲノム解析 / 肉腫 / HDAC阻害剤 / microRNA / 悪性骨軟部腫瘍 / Adenovirus vector / MC3T3-EI / Human mesenchymal stem cells / HuBone-NOD-SCID mice / 運動療法 / 力学負荷 / POEM / 軟骨細胞 / 内軟骨性骨化 / 骨芽細胞 / Signal Sequence Trap / アデノウイルスベクター / MC3T3-E1 / ヒト間葉系幹細胞 / HuBone-NOD-SCIDマウス / 細胞分化 / 破骨細胞分化 / Notchシグナル / 骨・軟骨代謝 / 免疫学 / 造血 / shedding / 骨代謝 / 治療薬 / 骨粗鬆症 / 細胞株 / レトロウイルス / Abelson virus / 不死化 / 破骨細胞 / トランスレーショナルリサーチ / 発現制御 / 細胞・組織 / 再生医学 / 外科 Less

腱・靭帯骨化と間葉系幹細胞の老化に関する研究
- Principal Investigator
  
  安田明正
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Hospital Organization Saitama National Hospital
骨格筋萎縮・変性における間葉系前駆細胞の機能解析Principal Investigator
- Principal Investigator
  
  堀内圭輔
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Defense Medical College
エネルギー代謝における思春期特発性側弯症関連遺伝子LBX1の機能解析
- Principal Investigator
  
  北村和也
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Defense Medical College
Development of novel treatment for intervertebral disc degeneration
- Principal Investigator
  
  Fujita Nobuyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Fujita Health University
Analysis of skeletal muscle homeostasis and muscle degenerationPrincipal Investigator
- Principal Investigator
  
  Horiuchi Keisuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  National Defense Medical College
Investigation of the potential involvement of LBX1 in the development of adolescent idiopathic scoliosis
- Principal Investigator
  
  IMABAYASHI Hideaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Keio University
  National Defense Medical College
Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
- Principal Investigator
  
  Matsuda Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Integrative omics analysis for novel therapeutic target molecules for soft tissue sarcoma of rare cancer
- Principal Investigator
  
  Morioka Hideo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  独立行政法人国立病院機構(東京医療センター臨床研究センター)
  Keio University
進行性悪性骨軟部腫瘍に対する治療標的としての新規microRNAの同定
- Principal Investigator
  
  西本和正
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Regulation of bone and cartilage formation by ADAM10
- Principal Investigator
  
  Yoda Masaki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Functional analysis of ADAMs in the musculoskeletal and hematopoietic systemPrincipal Investigator
- Principal Investigator
  
  Horiuchi Keisuke
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Involvement in bone metabolism of Notch signaling regulated by ADAM10
- Principal Investigator
  
  YODA MASAKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Identification and cell line establishment of human osteoclast precursor cell
- Principal Investigator
  
  FURUKAWA Mitsuru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Analysis of the functions of TACE in bone metabolism and hematopoiesisPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Keisuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
A Role of MMP-13 in Inflammatory Bone and Cartilage Destruction
- Principal Investigator
  
  TAKAISHI Hironari
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Studies of TACE in bone biology and inflammatory diseasesPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Keisuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Development of bone regeneration therapy for osteoporosis using humanized mice
- Principal Investigator
  
  TOYAMA Yoshiaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University

[Book] 関節外科筋衛星細胞の機能と恒常性維持2014
- Author(s)
  堀内圭輔，水野早希子, 松本守雄, 中村雅也
- Total Pages
  9
- Publisher
  メジカルビュー社
- Data Source
  KAKENHI-PROJECT-24390358
[Book] Emerging rolesof TACE as a central component ofectodomain shedding in vivo2009
- Author(s)
  Horiuchi, K
- Publisher
  Tanpakushitsu Kakusan Koso
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Aging Aggravates the Progression of Muscle Degeneration After Rotator Cuff Tears in Mice2022
- Author(s)
  Takada Yuhei、Matsumura Noboru、Shirasawa Hideyuki、Yoda Masaki、Matsumoto Morio、Nakamura Masaya、Horiuchi Keisuke
- Journal Title
  
  Arthroscopy: The Journal of Arthroscopic & Related Surgery
  
  Volume: 38 Issue: 3 Pages: 752-760
- DOI
  10.1016/j.arthro.2021.09.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09636, KAKENHI-PROJECT-20K09488, KAKENHI-PROJECT-21K09309
[Journal Article] Retinoic Acid Receptor Agonists Suppress Muscle Fatty Infiltration in Mice2021
- Author(s)
  Shirasawa, H., Matsumura, N., Yoda, M., Okubo, K., Shimoda, M., Uezumi, A., Matsumoto, M., Nakamura, M., Horiuchi, K.
- Journal Title
  
  Am J Sports Med
  
  Volume: 2 Issue: 2 Pages: 332-339
- DOI
  10.1177/0363546520984122
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09636, KAKENHI-PROJECT-20K09488
[Journal Article] Metastasis of Renal Cell Carcinoma to the Trapezium2017
- Author(s)
  Nakagawa Rumi、Susa Michiro、Nakayama Robert、Watanabe Itsuo、Horiuchi Keisuke、Toyama Yoshiaki、Nakamura Masaya、Matsumoto Morio、Morioka Hideo
- Journal Title
  
  The Journal of Hand Surgery (Asian-Pacific Volume)
  
  Volume: 22 Issue: 02 Pages: 262-265
- DOI
  10.1142/s0218810417720212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10874
[Journal Article] Wide-spread ignorance on the treatment of subcutaneous malignant tumors; a questionnaire-based study2017
- Author(s)
  Kikuta Kazutaka、Nakayama Robert、Yamaguchi Sayaka、Nishiwaki Yuuji、Susa Michiro、Nishimoto Kazumasa、Horiuchi Keisuke、Nakamura Masaya、Matsumoto Morio、Morioka Hideo
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 48 Issue: 2 Pages: 130-134
- DOI
  10.1093/jjco/hyx184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10874, KAKENHI-PROJECT-16H02676
[Journal Article] CT guided cryoablation for locally recurrent or metastatic bone and soft tissue tumor: initial experience.2016
- Author(s)
  Susa M, Kikuta K, Nakayama R, Nishimoto K, Horiuchi K, Oguro S, Inoue M, Yashiro H, Nakatsuka S, Nakamura M, Matsumoto M, Chiba K, Morioka H.
- Journal Title
  
  BMC Cancer.
  
  Volume: 16 Pages: 798-798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10874
[Journal Article] The unfolded protein response in skeletal development and homeostasis2016
- Author(s)
  Horiuchi K, Tohmonda T, Morioka H
- Journal Title
  
  Cell and Molecular Life Science
  
  Volume: na Issue: 15 Pages: 2851-69
- DOI
  10.1007/s00018-016-2178-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-16K10836
[Journal Article] Results of sub-analysis of a phase 2 study on trabectedin treatment for extraskeletal myxoid chondrosarcoma and mesenchymal chondrosarcoma.2016
- Author(s)
  Morioka H, Takahashi S, Araki N, Sugiura H, Ueda T, Takahashi M, Yonemoto T, Hiraga H, Hiruma T, Kunisada T, Matsumine A, Susa M, Nakayama R, Nishimoto K, Kikuta K, Horiuchi K, Kawai A
- Journal Title
  
  BMC Cancer
  
  Volume: 16 Issue: 1 Pages: 479-479
- DOI
  10.1186/s12885-016-2511-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-26293342, KAKENHI-PROJECT-15K20017, KAKENHI-PROJECT-16K10862, KAKENHI-PROJECT-16K10874
[Journal Article] Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis2015
- Author(s)
  Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan DH, Kong HH, Amagai M, Nagao K
- Journal Title
  
  Immunity
  
  Volume: 42 Issue: 4 Pages: 756-66
- DOI
  10.1016/j.immuni.2015.03.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390358
[Journal Article] Generation and characterization of a novel shoulder contracture mouse model2015
- Author(s)
  Oki S, Shirasawa H, Yoda M, Matsumura N, Tohmonda T, Yuasa K, Nakamura M, Matsumoto M, Horiuchi K
- Journal Title
  
  Journal of Orthopeadic Research
  
  Volume: 33 Issue: 11 Pages: 1732-8
- DOI
  10.1002/jor.22943
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358
[Journal Article] Dysbiosis drives inflammation in a model of atopic dermatitis2015
- Author(s)
  Kobayashi T, Glatz M, Horiuchi K, Kawasaki H, Akiyama H, Kaplan D, Kong H, Amagai M, Nagao K
- Journal Title
  
  Immunity
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390358
[Journal Article] A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool2015
- Author(s)
  Mizuno S, Yoda M, Shimoda M, Tohmonda T, Okada Y, Toyama Y, Takeda S, Nakamura M, Matsumoto M, Horiuchi K.
- Journal Title
  
  Journal of Biological chemistry
  
  Volume: 290 Issue: 47 Pages: 28456-64
- DOI
  10.1074/jbc.m115.653477
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-25282202
[Journal Article] ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function.2015
- Author(s)
  Cui, D., Arima, M., Takubo, K., Kimura, T., Horiuchi, K., Minagawa, T., Matsuda, S., and Ikeda, E.
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Issue: 1 Pages: 12796-12796
- DOI
  10.1038/srep12796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15157, KAKENHI-PUBLICLY-15H01164, KAKENHI-PROJECT-24390358
[Journal Article] IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis2015
- Author(s)
  Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K.
- Journal Title
  
  J Clin Investigation
  
  Volume: 125(8) Issue: 8 Pages: 3269-79
- DOI
  10.1172/jci76765
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-24390358
[Journal Article] ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.2014
- Author(s)
  Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, Horiuchi K
- Journal Title
  
  Cytokine
  
  Volume: 71 Issue: 2 Pages: 238-245
- DOI
  10.1016/j.cyto.2014.10.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-24791566
[Journal Article] Histochemical aspects of the vascular invasion at the erosion zone of the epiphyseal cartilage in MMP-9-deficient mice2013
- Author(s)
  Kojima, T. Hasegawa, T. de Freitas, P. H. Yamamoto, T. Sasaki, M. Horiuchi, K. Hongo, H. Yamada, T. Sakagami, N. Saito, N. Yoshizawa, M. Kobayashi, T. Maeda, T. Saito, C. Amizuka, N.
- Journal Title
  
  Biomed. Res.
  
  Volume: 34 Issue: 3 Pages: 119-128
- DOI
  10.2220/biomedres.34.119
- NAID
  130004470842
- ISSN
  0388-6107, 1880-313X
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390358
[Journal Article] Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo2013
- Author(s)
  Yoda M, Kimura T, Tohmonda T, Morioka H, Matsumoto M, Okada Y, Toyama Y, Horiuchi K
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Issue: 1 Pages: e54412-e54412
- DOI
  10.1371/journal.pone.0054412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones2013
- Author(s)
  Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Issue: 1 Pages: e54853-e54853
- DOI
  10.1371/journal.pone.0054853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] iRHOM2 is a critical pathogenic mediator of inflammatory arthritis2013
- Author(s)
  Issuree, P. D. Maretzky, T. McIlwain, D. R. Monette, S. Qing, X. Lang, P. A. Swendeman, S. L. Park-Min, K. H. Binder, N. Kalliolias, G. D. Yarilina, A. Horiuchi, K. Ivashkiv, L. B. Mak, T. W. Salmon, J. E. Blobel, C. P.
- Journal Title
  
  J Clin Invest
  
  Volume: 123 Pages: 928-32
- DOI
  10.1172/jci66168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390358
[Journal Article] A Brief History of Tumor Necrosis Factor α – converting Enzyme: An Overview of Ectodomain Shedding2013
- Author(s)
  Horiuchi, K.
- Journal Title
  
  The Keio Journal of Medicine
  
  Volume: 62 Issue: 1 Pages: 29-36
- DOI
  10.2302/kjm.2012-0003-RE
- NAID
  10031160104
- ISSN
  0022-9717, 1880-1293
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390358
[Journal Article] Stress-induced production ofchemokines by hair follicles regulates thetrafficking of dendritic cells in skin2012
- Author(s)
  Nagao, K., T. Kobayashi, K. Moro, M.Ohyama, T. Adachi, D. Y. Kitashima, S.Ueha, K. Horiuchi, H. Tanizaki, K.Kabashima, A. Kubo, Y. H. Cho, B. E.Clausen, K. Matsushima, M. Suematsu,G. C. Furtado, S. A. Lira, J. M. Farber,M. C. Udey, and M. Amagai.
- Journal Title
  
  NatImmunol
  
  Volume: 13 Pages: 744-752
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Enhanced susceptibility to lipopolysaccharide-induced arthritis and endotoxin shock in interleukin-32 alpha transgenic mice through induction of tumor necrosis factor alpha2012
- Author(s)
  Nakayama M, Niki Y, Kawasaki T, Takeda Y, Horiuchi K, Sasaki A, Okada Y, Umezawa K, Ikegami H, Toyama Y, Miyamoto T.
- Journal Title
  
  Arthritis Res Ther
  
  Volume: 14(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591690
[Journal Article] TACE (ADAM17)inhibits Schwann cell myelination2012
- Author(s)
  La Marca, R., F. Cerri, K. Horiuchi, A.Bachi, M. L. Feltri, L. Wrabetz, C. P.Blobel, A. Quattrini, J. L. Salzer, and C.Taveggia.
- Journal Title
  
  NatNeurosci
  
  Volume: 14 Pages: 857-865
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Lungendothelial ADAM17 regulates the acuteinflammatory response tolipopolysaccharide.2012
- Author(s)
  Dreymueller, D., C. Martin, T. Kogel, J.Pruessmeyer, F. M. Hess, K. Horiuchi, S.Uhlig, and A. Ludwig.
- Journal Title
  
  EMBO Mol Med
  
  Volume: 4 Pages: 412-423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] EpidermalADAM17 maintains the skin barrier byregulating EGFR ligand-dependentterminal keratinocyte differentiation2012
- Author(s)
  Franzke, C. W., C. Cobzaru, A.Triantafyllopoulou, S. Loffek, K.Horiuchi, D. W. Threadgill, T. Kurz, N.van Rooijen, L. Bruckner-Tuderman,and C. P. Blobel.
- Journal Title
  
  JExp Med
  
  Volume: 209 Pages: 1105-1119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Brief report: requirement ofTACE/ADAM17 for hair follicle bulgeniche establishment.2012
- Author(s)
  Nagao, K., T. Kobayashi, M. Ohyama, H.Akiyama, K. Horiuchi, and M. Amagai
- Journal Title
  
  Stem Cells
  
  Volume: 30 Pages: 1781-1785
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis2011
- Author(s)
  Yoda M, Kimura T, Tohmonda T, Uchikawa S, Koba T, Takito J, Morioka H, Matsumoto M, Link DC, Chiba K, Okada Y, Toyama Y, Horiuchi K
- Journal Title
  
  Blood
  
  Volume: 118(26) Issue: 26 Pages: 6939-42
- DOI
  10.1182/blood-2011-06-357210
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230
[Journal Article] Activation ofTNFR1 ectodomain shedding bymitochondrial Ca2+ determines theseverity of inflammation in mouse lungmicrovessels.2011
- Author(s)
  Rowlands, D. J., M. N. Islam, S. R. Das,A. Huertas, S. K. Quadri, K. Horiuchi, N.Inamdar, M. T. Emin, J. Lindert, V. S.Ten, S. Bhattacharya, and J.Bhattacharya
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Pages: 1986-1999
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] The IRE1alpha-XBP1pathway is essential for osteoblastdifferentiation through promotingtranscription of Osterix.2011
- Author(s)
  Tohmonda, T., Y. Miyauchi, R. Ghosh,M. Yoda, S. Uchikawa, J. Takito, H.Morioka, M. Nakamura, T. Iwawaki, K.Chiba, Y. Toyama, F. Urano, and K.Horiuchi.
- Journal Title
  
  EMBO Rep
  
  Volume: 12 Pages: 451-457
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Leukocyte ADAM17 RegulatesAcute Pulmonary Inflammation.2011
- Author(s)
  Arndt, P. G., B. Strahan, Y. Wang, C.Long, K. Horiuchi, and B. Walcheck
- Journal Title
  
  PLoSOne
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Dual functions ofcell-autonomous and non-cell-autonomous ADAM10 activityin granulopoiesis2011
- Author(s)
  Yoda, M., T. Kimura, T. Tohmonda, S.Uchikawa, T. Koba, J. Takito, H.Morioka, M. Matsumoto, D. C. Link, K.Chiba, Y. Okada, Y. Toyama, and K.Horiuchi.
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 6939-6942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Gene expression profilingof mouse growth plate cartilage by lasermicrodissection and microarray analysis.2011
- Author(s)
  Isshiki, H., K. Sato, K. Horiuchi, S.Tsutsumi, M. Kano, H. Ikegami, H. Abe,A. Umezawa, H. Aburatani, and Y.Toyama.
- Journal Title
  
  J Orthop Sci
  
  Volume: 16 Pages: 670-672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Tumor Necrosis Factor-alphaConverting Enzyme InactivationAmeliorates High-Fat Diet-InducedInsulin Resistance and Altered EnergyHomeostasis2011
- Author(s)
  Kaneko, H., T. Anzai, K. Horiuchi, K.Morimoto, A. Anzai, T. Nagai, Y. Sugano,Y. Maekawa, H. Itoh, T. Yoshikawa, Y.Okada, S. Ogawa, and K. Fukuda
- Journal Title
  
  Circ J
  
  Volume: 75 Pages: 2482-2490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Tumornecrosis factor-alpha converting enzymeis a key mediator of abdominal aorticaneurysm development.2011
- Author(s)
  Kaneko, H., T. Anzai, K. Horiuchi, T.Kohno, T. Nagai, A. Anzai, T. Takahashi,A. Sasaki, M. Shimoda, Y. Maekawa, H.Shimizu, T. Yoshikawa, Y. Okada, R.Yozu, and K. Fukuda.
- Journal Title
  
  Atherosclerosis
  
  Volume: 218 Pages: 470-478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] ADAM17 deletion in thymic epithelialcells alters aire expression withoutaffecting T cell developmentalprogression.2010
- Author(s)
  Gravano, D. M., B. T. McLelland, K.Horiuchi, and J. O. Manilay.
- Journal Title
  
  PLoS One
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Invivo role of leukocyte ADAM17 in theinflammatory and host responses duringE. coli-mediated peritonitis.2010
- Author(s)
  Long, C., Y. Wang, A. H. Herrera, K.Horiuchi, and B. Walcheck.
- Journal Title
  
  J LeukocBiol
  
  Volume: 87 Pages: 1097-1101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Ectodomain shedding ofEGFR ligands and TNFR1 dictateshepatocyte apoptosis during fulminanthepatitis in mice.2010
- Author(s)
  Murthy, A., V. Defamie, D. S. Smookler,M. A. Di Grappa, K. Horiuchi, M.Federici, M. Sibilia, C. P. Blobel, and R.Khokha.
- Journal Title
  
  J Clin Invest
  
  Volume: 120 Pages: 2731-2744
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Receptor Activator of NF-{kappa}B(RANK) Ligand Induces EctodomainShedding of RANK in Murine RAW264.7Macrophages.2010
- Author(s)
  Hakozaki, A., M. Yoda, T. Tohmonda, M.Furukawa, T. Hikata, S. Uchikawa, H.Takaishi, M. Matsumoto, K. Chiba, K.Horiuchi, and Y. Toyama
- Journal Title
  
  J Immunol
  
  Volume: 184 Pages: 2442-2448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Emerging roles of TACE as a central component of ectodomain shedding in vivo2009
- Author(s)
  Horiuchi, K
- Journal Title
  
  核酸・酵素・蛋白 54
  
  Pages: 1728-1734
- NAID
  40016835261
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Conditional inactivation of TACE by aSox9 promoter leads to osteoporosis andincreased granulopoiesis viadysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi, K., T. Kimura, T. Miyamoto, K.Miyamoto, H. Akiyama, H. Takaishi, H.Morioka, T. Nakamura, Y. Okada, C. P.Blobel, and Y. Toyama.
- Journal Title
  
  J Immunol
  
  Volume: 182 Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Ectodomain shedding ofFLT3 ligand is mediated by TNF-alphaconverting enzyme.2009
- Author(s)
  Horiuchi, K., H. Morioka, H. Takaishi,H. Akiyama, C. P. Blobel, and Y.Toyama
- Journal Title
  
  J Immunol
  
  Volume: 182 Pages: 7408-7414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.2009
- Author(s)
  Horiuchi K, Kimura T, ., et. al., 11名中6番目
- Journal Title
  
  J Immunol 182 (4)
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Conditional Inactivation of TACE by a Sox9 Promoter Leadsto Osteoporosis and Increased Granulopoiesis via Dysregulation of IL-17 and G-CSF12009
- Author(s)
  堀内圭輔
- Journal Title
  
  The Journal of Immunology 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] ADAMs 10 and 17represent differentially regulatedcomponents of a general sheddingmachinery for membrane proteins suchas transforming growth factor alpha,L-selectin, and tumor necrosis factoralpha2009
- Author(s)
  Le Gall, S. M., P. Bobe, K. Reiss, K.Horiuchi, X. D. Niu, D. Lundell, D. R.Gibb, D. Conrad, P. Saftig, and C. P.Blobel.
- Journal Title
  
  Mol Biol Cell
  
  Volume: 20 Pages: 1785-1794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Ectodomain shedding of FLT3 ligand is mediated by TACE2009
- Author(s)
  堀内圭輔
- Journal Title
  
  The Journal of Immunology 掲載決定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi, K, T. Kimura, T. Miyamoto, K. Miyamoto, H. Akiyama, H. Takaishi, H. Morioka, T. Nakamura, Y. Okada, C. P. Blobel and Y. Toyama.
- Journal Title
  
  J Immunol 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Ectodomain shedding of FLT3 ligand is mediated by TNF-alpha converting enzyme2009
- Author(s)
  Horiuchi, K., et al.
- Journal Title
  
  The Journal of Immunology 182
  
  Pages: 7408-7414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390424
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi K, Kimura T,. et. al., 11名
- Journal Title
  
  J Immunol 182(4)
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Ectodomain shedding of FLT3 ligand is mediated by TACE2009
- Author(s)
  Horiuchi K, Morioka H, et al., 6名中3番目
- Journal Title
  
  J Immunol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Posttranslational Regulation of Cell-Surface Colony-Stimulating Factor-12008
- Author(s)
  堀内圭輔
- Journal Title
  
  Critical Reviews in Immunology 28
  
  Pages: 215-227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ).2008
- Author(s)
  Horiuchi K, Morioka H, et., al., 13名中9番目
- Journal Title
  
  Cancer Lett 272
  
  Pages: 336-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Growth suppression and apoptosis induction in synovial sarcoma cell lines by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ)2008
- Author(s)
  Horiuchi K, Morioka H, et. al., 13名
- Journal Title
  
  Cancer Lett 272
  
  Pages: 336-344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] TNFα-Converting Enzyme(TACE/ADAM17)Inactivation in Mouse Myeloid Cells Prevents Lethality from Endotoxin Shock2007
- Author(s)
  堀内圭輔
- Journal Title
  
  The Journal of Immunology 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Cutting Edge : TNF-α-Converting Enzyme (TACE/ADAM17) Inactivation in Mouse Myeloid Cells Prevents Lethality from Endotoxin Shock2007
- Author(s)
  Horiuchi, K., T. Kimura, T. Miyamoto, H. Takaishi, Y. Okada, Y. Toyama, and C. P. Blobel
- Journal Title
  
  J Immunol 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Cell surface colony-stimulating factor l can be cleaved by TNFαconverting enzyme or endocytosed in a clathrin-dependent manner2007
- Author(s)
  堀内圭輔
- Journal Title
  
  The Journal of Immunology 179
  
  Pages: 6715-6724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock2007
- Author(s)
  Horiuchi K, Kimura T, et al., 7名
- Journal Title
  
  J Immunol 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Cutting edge:TNF-alpha-converting enzyme(TACE/ADAM17)inactivation in mouse my eloid cells prevents lethality from endotoxin shock2007
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Takaishi H, Okada Y, Toyama Y., Blobel CP.
- Journal Title
  
  J Immunol 179(5)
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner2007
- Author(s)
  Horiuchi, K., T. Miyamoto, H. Takaishi, A. Hakozaki, N. Kosaki, Y. Miyauchi, M. Furukawa, J. Takito, H. Kaneko, K. Matsuzaki, H. Morioka, C. P. Blobel, and Y. Toyama.
- Journal Title
  
  J Immunol 179
  
  Pages: 6715-6724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner2007
- Author(s)
  Horiuchi K, Miyamoto T, Takaishi H, Hakozaki A, Kosaki N, Miyauchi Y, Furukawa M, Takito J, Kaneko H, Matsuzaki K, Morioka H, Blobel CP, Toyama Y.
- Journal Title
  
  J Immunol 179(10)
  
  Pages: 6715-6724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] Cell surface colony-stimulating factor 1 can be cleaved by TNF-alpha converting enzyme or endocytosed in a clathrin-dependent manner2007
- Author(s)
  Horiuchi K, Miyamoto T, et al., 13名
- Journal Title
  
  J Immunol 179
  
  Pages: 6715-6724
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591764
[Journal Article] P. Saftig and C. P. Blobel1. 2009 ADAMs 10 and 17 are differentially regulated components of a general shedding machinery for TGFα, TNFα and other membrane proteins
- Author(s)
  Le Gall, S. M., P. Bob, K. Reiss, K. Horiuchi, D. Lundell, D. R. Gibb, D. Conrad
- Journal Title
  
  Mol Biol Cell 20
  
  Pages: 1785-1794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] C. P. Blobel and Y. Toyama. 2009. Ectodomain shedding of FLT3 ligand is mediated by TACE
- Author(s)
  Horiuchi, K, H. Morioka, H. Takaishi, H. Akiyama
- Journal Title
  
  J Immunol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Presentation] 側弯症関連遺伝子Lbx1 はマウスにおいてエネルギー代謝を負に制御する2023
- Author(s)
  中川敬博，堀内圭輔，石坂隆博，伊佐治雅，近藤晋哉，北村和也，千葉一裕
- Organizer
  第96回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-22K09320
[Presentation] 側弯症関連遺伝子Lbx1はマウスにおいてエネルギー代謝を負に制御する2023
- Author(s)
  中川敬博，堀内圭輔，石坂隆博，伊佐治雅，近藤晋哉，北村和也，千葉一裕
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-22K09320
[Presentation] 側弯症関連遺伝子Lbx1 はマウスにおいてエネルギー代謝を負に制御する2023
- Author(s)
  中川敬博，堀内圭輔，石坂隆博，石坂隆博，北村和也，千葉一裕
- Organizer
  第52回日本脊椎脊髄病学会
- Data Source
  KAKENHI-PROJECT-22K09320
[Presentation] 側弯症関連遺伝子Lbx1はマウスにおいてエネルギー代謝を負に制御する2023
- Author(s)
  中川敬博，堀内圭輔，近藤晋哉，伊佐治雅，石坂隆博，北村和也，千葉一裕
- Organizer
  第9回日本筋学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09320
[Presentation] マウスモデルを用いた骨格筋脂肪変性の解析2021
- Author(s)
  堀内圭輔
- Organizer
  第7回日本筋学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09636
[Presentation] ADAM10-Notchシグナル制御による筋再生促進および筋再生の画像評価2020
- Author(s)
  堀内圭輔
- Organizer
  第18回日本再生医療学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09636
[Presentation] 思春期特発性側弯症関連遺伝子 Lbx1 を骨格筋特異的に欠損したマウスは前肢の低形成を来すが, 脊柱変形は生じない2020
- Author(s)
  松橋優介，堀内圭輔，高橋洋平，渡邉航太，池川志郎，松本守雄，千葉一裕
- Organizer
  第93回日本整形外科学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09660
[Presentation] Conditional abrogation of Lbx1 in skeletal muscle results in defective forelimb development2020
- Author(s)
  松橋優介，堀内圭輔，高橋洋平，渡辺航太，池川士郎，松本守雄，千葉一裕
- Organizer
  Orthopaedic Research Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09660
[Presentation] 腱板断裂後の筋内脂肪浸潤には加齢と時間経過が必要である2020
- Author(s)
  高田裕平，松村昇，白澤英之，瀬戸貴之，辻阪亮介，中村匠，堀内圭輔
- Organizer
  第47日本肩関節学会
- Data Source
  KAKENHI-PROJECT-19K09636
[Presentation] Retinoic acid receptor agonists suppress fatty infiltration in a mouse model of rotator cuff tear2019
- Author(s)
  松村昇，白澤英之，大木聡，松本守雄，中村雅也，堀内圭輔
- Organizer
  American Shoulder and Elbow Surgeons
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09636
[Presentation] 老齢マウスを用いた腱板断裂後脂肪浸潤モデルの作成とその評価2019
- Author(s)
  高田裕平，松村昇，白澤英之，瀬戸貴之，堀内圭輔
- Organizer
  第46回日本肩関節学会
- Data Source
  KAKENHI-PROJECT-19K09636
[Presentation] TNIK is a novel molecular target for osteosarcoma treatment and controls osteosarcoma cell fate.2018
- Author(s)
  Hirozane T, Masuda M, Goto N, Sugano T, Asano N, Kobayashi E, Kawa A, Horiuchi K, Matsumoto M, Nakamura M, Sawa M, Morioka H, Nakayama R, Yamada T
- Organizer
  Conective Tissue Oncology Society 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] Spontaneous regression of soft tissue sarcoma.2018
- Author(s)
  Susa M, Horiuchi K, Saito M, Sato C, Nakayama R, Morioka H, Chiba K
- Organizer
  Conective Tissue Oncology Society 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] Treatment of soft tissue sarcomas in patients age 80 years or older2018
- Author(s)
  Susa M, Kobayashi E, Horiuchi K, Nakayama R, Watanabe I, Morioka H, Kawai A, Chiba K
- Organizer
  12th Asia Pacific Musculoskeletal Tumor Society Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] Efficacy of FDG-PET in the Detection of Local Recurrence after Limb Salvage Surgery Using Metal Implants.2017
- Author(s)
  Sekita T, Nakayama R, Kikuta K, Horiuchi K, Susa M, Nakamura M, Matsumoto M, Morioka H
- Organizer
  19th International Society of Limb Salvage General Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] Treatment of soft tissue sarcoma in patients age 80 year or older.2017
- Author(s)
  Susa M, Horiuchi K, Sato C, Chiba K, Nakayama R, Watanabe I, Morioka H
- Organizer
  22nd Connective Tissue Oncology Society Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] Clinical Outcome of Ten Cases of Lipoblastoma.2017
- Author(s)
  Sekita T, Nakayama R, Kikuta K, Horiuchi K, Susa M, Nakamura M, Matsumoto M, Morioka H
- Organizer
  19th International Society of Limb Salvage General Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] Therapeutic Potential of a Novel TRAF2 and NCK-Interacting Protein Kinase Inhibitor against Osteosarcoma.2017
- Author(s)
  Hirozane T, Masuda M, Goto N, Kobayashi E, Horiuchi K, Matsumoto M, Nakamura M, Morioka H, Sawa M, Yamada T
- Organizer
  19th International Society of Limb Salvage General Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] Efficacy of pazopanib for recurrent desmoid tumors in kamilial adenomatous polyposis patients.2017
- Author(s)
  Susa M, Horiuchi K, Sekita T, Nakayama R, Morioka H, Chiba K
- Organizer
  22nd Connective Tissue Oncology Society Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10874
[Presentation] 筋再生におけるADAM10の役割2016
- Author(s)
  堀内圭輔
- Organizer
  第21回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター（大阪府豊中市）
- Year and Date
  2016-08-06
- Invited
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] IRE1α-XBP1を介した不良タンパク質応答は破骨細胞分化を正に制御する2015
- Author(s)
  堀内圭輔
- Organizer
  第9回骨・軟骨フロンティア
- Place of Presentation
  ベルサール八重洲（東京都中央区）
- Year and Date
  2015-11-07
- Invited
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] TNFα-converting enzyme （TACE/ADAM17)はEGFRを介して成長板肥大層の吸収を間接的に制御する2013
- Author(s)
  堀内圭輔
- Organizer
  第28回日本整形外科学会基礎学術集会
- Place of Presentation
  千葉，幕張
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] The systemic overexpression of TACE does not lead to enhanced shedding activity in vivo2013
- Author(s)
  Keisuke Horiuchi
- Organizer
  Matrix Metalloprotease Gordon Research Conference
- Place of Presentation
  Lucca, Italy
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 小胞体ストレス応答分子IRE1-XBP1によるPTHRの発現制御2012
- Author(s)
  堀内圭輔
- Organizer
  第13回運動器科学研究会
- Place of Presentation
  京都
- Year and Date
  2012-09-08
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 軟骨細胞特異的にTACEを不活化したマウスは成長板の肥厚と長管骨の成長障害を生じる2012
- Author(s)
  堀内圭輔
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  ウィルあいち(名古屋)
- Year and Date
  2012-03-09
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] ADAM10-Notchシグナル伝達を介した骨髄系細胞分化はG-CSF依存的および非依存的な経路によって制御されている2012
- Author(s)
  依田昌樹,戸山芳昭,堀内圭輔
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-23592230
[Presentation] The systemic overexpression of TACE does not lead to enhanced shedding activity in vivo2012
- Author(s)
  堀内圭輔
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡(招待講演)
- Year and Date
  2012-12-13
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 軟骨細胞特異的にADAM10を欠損したマウスは著明な成長障害を呈する2012
- Author(s)
  堀内圭輔
- Organizer
  第27回日本整形外科学会基礎学術集会
- Place of Presentation
  名古屋
- Year and Date
  2012-10-27
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] ADAM10-Notch signaling regulates granulopoiesis via G-CSF-dependent and -independent manners2012
- Author(s)
  Masaki Yoda, Yoshiaki Toyama, Keisuke Horiuchi
- Organizer
  第35回　日本分子生物学会
- Place of Presentation
  福岡国際会議場、マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-23592230
[Presentation] Conditional inactivation of TACE in chondroblasts results in shorter long bones and defective fracture healing2011
- Author(s)
  Keisuke Horiuchi
- Organizer
  Gordon Research Conference (Regulated Proteolysis of Cell Surface Proteins)
- Place of Presentation
  Davidson, NC, USA
- Year and Date
  2011-07-12
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] IL-1受容体シグナリングにおけるTNF-α converting enzyme (TACE) の機能解析2011
- Author(s)
  内川伸一, 依田昌樹, 千葉一裕, 堀内圭輔, and 戸山芳昭
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2011-07-20
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] IL-1受容体シグナルにおけるTNFα converting enzyme (TACE) の機能解析2011
- Author(s)
  内川伸一, 依田昌樹, 千葉一裕, 堀内圭輔, and 戸山芳昭
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 小胞体ストレス応答機構Xbp1α-XBP1経路は,骨芽細胞分化過程において活性化されOsterixの転写を促進する2011
- Author(s)
  東門田誠一, 宮内芳輝, 千葉一裕,戸山芳昭, and 堀内圭輔
- Organizer
  第29回日本骨代謝学会学術集会
- Place of Presentation
  神戸
- Year and Date
  2011-07-20
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Conditionalinactivation of TACE inchondroblasts results in shorterlong bones and defective fracturehealing.2011
- Author(s)
  Horiuchi, K., K. Saito, T. Kimura, K. Sato, Y. Okada, and Y. Toyama
- Organizer
  Gordon ResearchConference (Regulated Proteolysisof Cell Surface Proteins)
- Place of Presentation
  Davidson,NC USA
- Year and Date
  2011-07-14
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 小胞体ストレス応答経路であるIRE1α-XBP1はBMPによる骨芽細胞分化に必須である2011
- Author(s)
  堀内圭輔
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  群馬県民会館(前橋)
- Year and Date
  2011-11-21
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 2型コラーゲンプロモーターによりTACEを不活化したマウスは骨の成長障害を来たす2011
- Author(s)
  堀内圭輔, 斉藤憲太, 木村徳宏, 佐藤和毅, 秋山治彦, 岡田保典, 千葉一裕, and 戸山芳昭
- Organizer
  第43回日本結合組織学会学術集会,第58回マトリックス研究会大会合同学術集会
- Place of Presentation
  別府
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 2型コラーゲンプロモーターによりTACEを不活化したマウスは骨の成長障害を来たす2011
- Author(s)
  堀内圭輔
- Organizer
  43回日本結合組織学会学術集会,第58回マトリックス研究会大会合同学術集会
- Place of Presentation
  大分ビーコンプラザ(大分)
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Regulation of myelination bysecretase: role of Adam17/TACE2011
- Author(s)
  La Marca, R., F. Cerri, K. Horiuchi,A. Bachi, M. Laura Fltri, L. Wrabetz,C. P. Blobel, J. L. Salzer, and C.Taveggia
- Organizer
  Society of Neuroscience meeting
- Place of Presentation
  Washington USA
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 小胞体ストレス応答経路であるIRE1α-XBP1はBMPによる骨芽細胞分化に必須である2011
- Author(s)
  堀内圭輔, 東門田誠一, 森岡秀夫,戸山芳昭, and 千葉一裕
- Organizer
  第26回日本整形外科学会基礎学術集会
- Place of Presentation
  前橋
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 小胞体ストレス応答機構Xbp1α-XBP1経路は,骨芽細胞分化過程において活性化されOsterixの転写を促進する2011
- Author(s)
  東門田誠一, 戸山芳昭, and 堀内圭輔
- Organizer
  第12回運動器学研究会
- Place of Presentation
  高知
- Year and Date
  2011-09-03
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 2型コラーゲンプロモーターによりTACEを不活化したマウスは骨の成長障害を来たす2010
- Author(s)
  堀内圭輔, 斎藤憲太, 高石官成, 秋山治彦, 佐藤和毅, 中村孝志, 千葉一裕, and 戸山芳昭
- Organizer
  第83回日本整形外科学会学術総会
- Place of Presentation
  東京
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Studiesfrom TACE mutant mice2010
- Author(s)
  Horiuchi, K.
- Organizer
  The 33rdAnnual Meeting of the MolecularBiology Society of Japan
- Place of Presentation
  Kobe
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 軟骨細胞分化および骨折治療過程におけるTNFαconverting enzyme(TACE)の機能解析2010
- Author(s)
  斎藤憲太, 堀内圭輔, 木村徳宏, 佐藤和毅, 千葉一裕, 秋山治彦, and 戸山芳昭
- Organizer
  第25回日本整形外科学会基礎学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 2型コラーゲンプロモーターによりTACEを不活化したマウスは骨の成長障害を来たす2010
- Author(s)
  堀内圭輔, 斉藤憲太, 木村徳宏, 佐藤和毅, 秋山治彦, 岡田保典, 千葉一裕, and 戸山芳昭
- Organizer
  第11回運動器学研究会
- Place of Presentation
  軽井沢
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 軟骨細胞分化におよび骨折治癒過程におけるTNFaconverting enzyme (TACE)の機能解析2010
- Author(s)
  斎藤憲太, 堀内圭輔, 木村徳宏, 佐藤和毅, 千葉一裕, 秋山治彦, and 戸山芳昭.
- Organizer
  第23回日本軟骨代謝学会
- Place of Presentation
  鹿児島
- Year and Date
  2010-04-02
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Studies from TACE Mutant Mice2010
- Author(s)
  Horiuchi, K
- Organizer
  Biochemistry and Molecular Biology 2010
- Place of Presentation
  Kobe
- Year and Date
  2010-12-19
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Inhibitory effect of HGF on BMP-2 induced osteoblast differentiationin vitro.2010
- Author(s)
  Kawasaki, T., Y. Niki, T. Miyamoto,K. Horiuchi, M. Matsumoto, M. Aizawa,and Y. Toyama
- Organizer
  56th Annual Meeting ofthe Orthopaedic Research Society
- Place of Presentation
  New Orleans, Louisiana USA
- Year and Date
  2010-03-06
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] TACEはFlt3リガンドを可溶化する主要な酵素である2009
- Author(s)
  堀内圭輔
- Organizer
  第24回日本整形外科学会基礎学術集会
- Place of Presentation
  横浜
- Year and Date
  2009-11-06
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Studiesfrom TACE muntant mice.2009
- Author(s)
  堀内圭輔
- Organizer
  JointConference of 8th Pan-PacificConnective Tissue SocietiesSymposium (PPCTSS), 41st AnnualMeeting of the Japanese Society ofConnective Tissue Research (JSCTR),and 56th Annual Meeting of the JapanMatrix Club (JMC)
- Place of Presentation
  横須賀
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 2型コラーゲンプロモーターによりTACEを不活化したマウスは骨の成長障害を来たす2009
- Author(s)
  堀内圭輔
- Organizer
  第27回日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Studies from TACE muntant mice2009
- Author(s)
  堀内圭輔
- Organizer
  Joint Conference of 8th Pan-Pacific Connective Tissue Societies Symposium, 41st Annual Meeting of the Japanese Society of Connective Tissue Research, and 56th Annual Meeting of the Japan Matrix Club
- Place of Presentation
  横須賀
- Year and Date
  2009-06-05
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] 2型コラーゲンプロモーターによりTACEを不活化したマウスは骨の成長障害を来たす2009
- Author(s)
  堀内圭輔, 高石官成, 秋山治彦, 中村考志, and 戸山芳昭
- Organizer
  第27回日本骨代謝学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporo sis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  堀内圭輔
- Organizer
  Gordon Research Conference(MMP)
- Place of Presentation
  Les Diablerets, Switzerland
- Year and Date
  2009-09-02
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] Conditional inactivation of TACE bya Sox9 promoter leads toosteoporosis and increasedgranulopoiesis via dysregulation ofIL-17 and G-CSF.2009
- Author(s)
  Horiuchi, K.
- Organizer
  MMP GordonResearch Conference.
- Place of Presentation
  les diablerets,Switzerland
- Year and Date
  2009-09-02
- Data Source
  KAKENHI-PROJECT-21390424
[Presentation] SOX9プロモーターにより TACEを不活化したマウスではIL-17・G-CSFの発現に異常を呈し、骨粗鬆症、造血異常を生じる2008
- Author(s)
  堀内圭輔
- Organizer
  第26回日本骨代謝学会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19591765
[Presentation] SOX9プロモーターによりTACEの不活化したマウスでは成長障害と骨粗鬆症を生じる2008
- Author(s)
  堀内圭輔
- Organizer
  日本整形外科基礎学術集会
- Place of Presentation
  京都
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-19591765
[Presentation] SOX9プロモーターによりTACEを不活化したマウスではIL-17・G-CSFの発現に異常を呈し、骨粗鬆症、造血異常を生じる2008
- Author(s)
  堀内圭輔
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19591765
[Presentation] SOX9プロモーターによりTACEの不活化したマウスでは成長障害と骨粗鬆症を生じる2008
- Author(s)
  堀内圭輔
- Organizer
  第23回日本整形外科基礎学術集会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-19591765
[Presentation] TACEはin vivoにおいてTNFαの可溶化に必須の分子である2007
- Author(s)
  堀内圭輔
- Organizer
  日本骨代謝学会
- Place of Presentation
  大阪
- Year and Date
  2007-07-19
- Data Source
  KAKENHI-PROJECT-19591765
[Presentation] 敗血症性ショックにおけるTACE/ADAM17の機能解析2007
- Author(s)
  堀内圭輔
- Organizer
  日本整形外科基礎学術集会
- Place of Presentation
  浜松
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-19591765
[Presentation] 筋肉のエイジング・アンチエイジング Notchシグナリングによる筋衛星細胞恒常性維持
- Author(s)
  堀内圭輔, 水野早希子, 戸山芳昭, 中村雅也
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 不良タンパク質応答に機能するIRE1α-XBP1経路は新規の破骨細胞分化誘導因子である
- Author(s)
  堀内圭輔, 東門田誠一, 依田昌樹, 松本守雄, 戸山芳昭
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 破骨細胞分化におけるIRE1α-XBP1経路の機能解析
- Author(s)
  東門田誠一, 依田昌樹, 松本守雄, 戸山芳昭, 堀内圭輔
- Organizer
  第32回日本骨代謝学会学
- Place of Presentation
  大阪
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] マウスを利用した新規肩関節拘縮モデルの作成およびその分子生物学的評価
- Author(s)
  大木聡, 依田昌樹, 木場健, 東門田誠一, 松村昇, 戸山芳昭, 堀内圭輔
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 軟骨特異的なADAM10-Notchシグナルの抑制は顕著な成長障害を来たす
- Author(s)
  依田昌樹，水野早希子，秋山治彦，松本守雄，戸山芳昭，堀内圭輔
- Organizer
  第32回日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-26462318
[Presentation] 軟骨細胞におけるADAM10-Notchシグナルの抑制は顕著な成長障害を来たす
- Author(s)
  依田昌樹，水野早希子，秋山治彦，戸山芳昭，松本守雄，堀内圭輔
- Organizer
  第28回日本軟骨代謝学会
- Place of Presentation
  東京
- Year and Date
  2015-03-06 – 2015-03-07
- Data Source
  KAKENHI-PROJECT-26462318
[Presentation] 廃用性筋萎縮における小胞体ストレス応答の機能解析
- Author(s)
  木場健, 湯浅和樹, 東門田誠一, 戸山芳昭, 中村雅也, 堀内圭輔
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24390358

1. TOYAMA Yoshiaki (40129549)

# of Collaborated Projects: 5 results

# of Collaborated Products: 31 results
2. YODA MASAKI (30464994)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. MIYAMOTO Takeshi (70383768)

# of Collaborated Projects: 2 results

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5. TAKAISHI Hironari (60236180)

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6. HAKOZAKI Akihiro (10365299)

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7. KIMURA Tokuhiro (40445200)

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8. OKADA Yasunori (00115221)

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11. HOZUMI Nobumichi (60051744)

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12. YAMADA Taketo (60230463)

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13. Matsuda Koichi (90401257)

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Horiuchi Keisuke 堀内 圭輔

HORIUCHI Keisuke 堀内 圭輔

堀内 圭輔 ホリウチ ケイスケ

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骨格筋萎縮・変性における間葉系前駆細胞の機能解析Principal Investigator

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Analysis of skeletal muscle homeostasis and muscle degenerationPrincipal Investigator

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Functional analysis of ADAMs in the musculoskeletal and hematopoietic systemPrincipal Investigator

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Analysis of the functions of TACE in bone metabolism and hematopoiesisPrincipal Investigator

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Horiuchi Keisuke 堀内圭輔

HORIUCHI Keisuke 堀内圭輔

堀内圭輔ホリウチケイスケ

[Book] 関節外科筋衛星細胞の機能と恒常性維持2014