KIMURA Tokuhiro 木村徳宏

Researcher Number	40445200
Affiliation (based on the past Project Information) *help	2018 – 2019: 山口大学, 医学部, 特別医学研究員 2017: 山口大学, 大学院医学系研究科, 講師 2014 – 2016: 山口大学, 医学(系)研究科(研究院), 講師 2007 – 2014: Keio University, 医学部, 助教 2010: 福慶義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Human pathology Except Principal Investigator Orthopaedic surgery / Experimental pathology / Parasitology (including Sanitary zoology)
Keywords	Principal Investigator 病理学 / 細胞・組織 / 細胞生物学 / 変形性関節症 / 関節 / 脳腫瘍 / 細胞外マトリックス / 軟骨 / 微小環境 / 浸透圧 … More / 膠芽腫 / 脳神経疾患 / 癌 / 細胞運動 / 軟骨下骨 / 骨 … More Except Principal Investigator 変形性関節症 / 免疫学 / 関節軟骨 / ADAM / MMP / 血管 / EMT / 急性大動脈解離 / 悪性腫瘍 / 組織リモデリング / TIMP / ドイツ / 国際情報交換 / 遺伝子欠損マウス / 感染症 / Leishmania major / microRNA / CSF-1 / 炎症 / Ectodomain Shedding / 骨代謝学 / TACE / ADAM17 / 骨・軟骨代謝学 / 血管進入 / 血管侵入 / 血管新生因子 / 神経反発因子 / 腎癌 / ヘパラナーゼ / 筋線維芽細胞 / カルシウムペントサン硫酸 / CD44 / IL-1 / アグリカナーゼ / ADAMTS4 / 血管新生 / 癌転移 / ELISA / セマフォリン / 動脈瘤 / エンドスタチン / ヒアルロン酸 / 創傷治癒 / 転移 / 浸潤 / ノックアウトマウス Less

Analysis of peri-necrotic microenvironment of glioblastoma via NFAT family transcription factorsPrincipal Investigator
- Principal Investigator
  
  KIMURA Tokuhiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Yamaguchi University
Analysis of pathophysiology of intratumoral microenvironments in glioblastoma using spheroid culture and histopathologyPrincipal Investigator
- Principal Investigator
  
  KIMURA Tokuhiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Yamaguchi University
Snailファミリーと軟骨細胞の遊走・分化に着目した変形性関節症の病態解析Principal Investigator
- Principal Investigator
  
  木村徳宏
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Pathological study on metalloproteinases in tissue remodeling under pathological conditions
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
Migratory potential of chondrocytes in human osteoarthritic cartilagePrincipal Investigator
- Principal Investigator
  
  KIMURA Tokuhiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Analysis of the functions of microRNAs in host immune responses to infection with Leishmania major
- Principal Investigator
  
  TANABE Masanobu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Keio University
Expression and function of RECK in human osteoarthritic subchondral bone tissuePrincipal Investigator
- Principal Investigator
  
  KIMURA Tokuhiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinases
- Principal Investigator
  
  OKADA Yasunori
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Experimental pathology
- Research Institution
  Keio University
The regulation of vascularity by Semaphorin-3A in the osteo-cartilaginous tissues
- Principal Investigator
  
  FUJITA Yoshinari
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Studies of TACE in bone biology and inflammatory diseases
- Principal Investigator
  
  HORIUCHI Keisuke
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Expression and function of RECK in human osteoarthritic cartilagePrincipal Investigator
- Principal Investigator
  
  KIMURA Tokuhiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  Keio University

All 2016 2015 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Histological Characterization of the Tumorigenic "Peri-Necrotic Niche" Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma.2016
- Author(s)
  Ishii A, Kimura T, Sadahiro H, Kawano H, Takubo K, Suzuki M, Ikeda E
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 1 Pages: e0147366-e0147366
- DOI
  10.1371/journal.pone.0147366
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460434
[Journal Article] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity.2015
- Author(s)
  Chijiiwa M., Mochizuki S., Kimura T., Abe H., Tanaka Y., Fujii Y., Shimizu H., Enomoto H., Toyama Y. and Okada Y.
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249022
[Journal Article] Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones2013
- Author(s)
  Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Issue: 1 Pages: e54853-e54853
- DOI
  10.1371/journal.pone.0054853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] Systemic overexpression of TNFα-converting enzyme does not lead to enhanced shedding activity in vivo2013
- Author(s)
  Yoda M, Kimura T, Tohmonda T, Morioka H, Matsumoto M, Okada Y, Toyama Y, Horiuchi K
- Journal Title
  
  PLoS One
  
  Volume: 8(1) Issue: 1 Pages: e54412-e54412
- DOI
  10.1371/journal.pone.0054412
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592230, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24390358
[Journal Article] Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy.2012
- Author(s)
  Murata M, Noda K, Fukuhara J, Kanda A, Kase S, Saito W, Ozawa Y, Mochizuki S, Kimura S, Mashima Y, Okada Y, Ishida S.
- Journal Title
  
  Invest Ophthalmol Vis Sci.
  
  Volume: 53 Issue: 7 Pages: 4055-62
- DOI
  10.1167/iovs.12-9857
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592588, KAKENHI-PROJECT-24249022, KAKENHI-PROJECT-24590490, KAKENHI-PROJECT-24592647
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor 165-promoted chondrocyte migration: An implication for chondrocyte cloning2011
- Author(s)
  Okubo M, Kimura T, Fujita Y, Mochizuki S, Niki Y, Enomoto H, Suda Y, Toyama Y, Okada Y.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790420
[Journal Article] Dual functions of cell-autonomous and non cell-autonomous ADAM10 activity in granulopoiesis2011
- Author(s)
  Yoda M., Kimura T., Link D.C., Chiba K., Okada Y., Matsumoto M., Toyama Y., Horiuchi K.
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 6939-6942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor 165-promoted chond rocyte migration2011
- Author(s)
  Masashi Okubo
- Journal Title
  
  Arthritis & Rheumatism
  
  Volume: 63 Issue: 10 Pages: 3000-3009
- DOI
  10.1002/art.30482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590421, KAKENHI-PROJECT-23790420
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_(165)-promoted chondrocyte migration : an implication for chondrocyte cloning2011
- Author(s)
  Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y. and Okada Y
- Journal Title
  
  Arthr itis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Semaphorin 3A is expressed in human osteoarthritic cartilage and antagonizes vascular endothelial growth factor_<165>-promoted chondrocyte migration : an implication for chondrocyte cloning2011
- Author(s)
  Okubo M., Kimura T., Fujita Y., Mochizuki S., Niki Y., Enomoto H., Suda Y., Toyama Y., Okada Y.
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Pages: 3000-3009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK Is Up-Regulated and Involved in Chondrocyte Cloning in Human Osteoarthritic Cartilage2010
- Author(s)
  Kimura T, Okada A, Yatabe T, Okubo M, Toyama Y, Noda M, Okada Y.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 176 Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790364
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.2010
- Author(s)
  Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S., Fukuda, K.
- Journal Title
  
  J Clin Invest
  
  Volume: 120 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK Is Up-Regulated and Involved in Chondrocyte Cloning in Human Osteoarthritic Cartilage.2010
- Author(s)
  Kimura T, Okada A, Yatabe T, Okubo M, Toyama Y, Noda M, Okada Y.
- Journal Title
  
  Am J Pathol. 176(6)
  
  Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790364
[Journal Article] Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents2010
- Author(s)
  Hakuno, D., Kimura, N., Yoshioka, M., Mukai, M., Kimura, T., Okada, Y., Yozu, R., Shukunami, C., Hiraki, Y., Kudo, A., Ogawa, S. and Fukuda, K
- Journal Title
  
  J. Clin. Invest
  
  Volume: 120 Pages: 2292-2306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage.2010
- Author(s)
  Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M., Okada Y.
- Journal Title
  
  Am J Pathol
  
  Volume: 176 Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] RECK is up-regulated and involved in chondrocyte cloning in human osteoarthritic cartilage2010
- Author(s)
  Kimura T., Okada A., Yatabe T., Okubo M., Toyama Y., Noda M. and Okada Y
- Journal Title
  
  Am. J. Pathol
  
  Volume: 176 Pages: 2858-2867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y, Blobel CP, and Toyama Y
- Journal Title
  
  J. Immunol
  
  Volume: 182 Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] PIAS3 negatively regulates RANKL-mediated osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblasts.2009
- Author(s)
  Hikata T, Takaishi H, Takito J, Hakozaki A, Furukawa M, Uchikawa S, Kimura T, Okada Y, Matsumoto M, Yoshimura A, Nishimura A, Reddy S V, Asahara H, Toyama Y.
- Journal Title
  
  Blood 113
  
  Pages: 2202-2212
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF.2009
- Author(s)
  Horiuchi K, Kimura T, Miyamoto T, Miyamoto K, Akiyama H, Takaishi H, Morioka H, Nakamura T, Okada Y. Blobel CP, Toyama Y
- Journal Title
  
  J Immunol 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Conditional inactivation of TACE by a Sox9 promoter leads to osteoporosis and increased granulopoiesis via dysregulation of IL-17 and G-CSF2009
- Author(s)
  Horiuchi, K, T. Kimura, T. Miyamoto, K. Miyamoto, H. Akiyama, H. Takaishi, H. Morioka, T. Nakamura, Y. Okada, C. P. Blobel and Y. Toyama.
- Journal Title
  
  J Immunol 182
  
  Pages: 2093-2101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic chondrocytes2009
- Author(s)
  Yatabe T., Mochizuki S., Takizawa M., Chijiiwa M., Okada A., Kimura T., Fujita Y., Matsumoto H., Toyama Y. and Okada Y
- Journal Title
  
  Ann. Rheum. Dis
  
  Volume: 68 Pages: 1051-1058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Hyaluronan inhibits expression of ADAMTS4 (aggrecanase-1)in humanosteoarthritic chondrocytes.2009
- Author(s)
  Yatabe T., Mochizuki S., Takizawa M. Chijiiwa M., Okada A., Kimura T., Fujita Y. Matsumoto H., Toyama Y, Okada Y.
- Journal Title
  
  Ann Rheum Dis (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteninase activation are associated with the rupture of the chordae tendineae cordis.2008
- Author(s)
  Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G, Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. Fukuda K.
- Journal Title
  
  Circulation 118
  
  Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis2008
- Author(s)
  Kimura N., Shukunami C., Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin' oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. and Fukuda K
- Journal Title
  
  Circulation
  
  Volume: 118 Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM12 (Meltrin α) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor-binding protein-5 in osteoarthritic cartilage2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y. and Okada Y
- Journal Title
  
  Arthritis Rheum
  
  Volume: 58 Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Local tenomodulin absence, angiogenesis, and matrix metalloproteinase activation are associated with the rupture of the chordae tendineae cordis.2008
- Author(s)
  Kimura N., Shukunami C, Hakuno D., Yoshikoka M., Miura S., Docheva D., Kimura T., Okada Y., Matsumura G., Shin'oka T., Yozu R., Kobayashi J., Ishibashi-Ueda H., Hiraki Y. And Fukuda K.
- Journal Title
  
  Circulation 118
  
  Pages: 1737-1747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] ADAM12 (Meltrin a) is involved in chondrocyte proliferation viacleavage of insulin-like growth factor-binding protein-5 in osteoarthriticcartilage.2008
- Author(s)
  Okada A., Mochizuki S., Yatabe T., Kimura T., Shiomi T., Fujita Y., Matsumoto H., Sehara-Fujisawa A., Iwamoto Y., Okada Y.
- Journal Title
  
  Arthritis Rheum 58
  
  Pages: 778-789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Journal Article] Cutting Edge : TNF-α-Converting Enzyme (TACE/ADAM17) Inactivation in Mouse Myeloid Cells Prevents Lethality from Endotoxin Shock2007
- Author(s)
  Horiuchi, K., T. Kimura, T. Miyamoto, H. Takaishi, Y. Okada, Y. Toyama, and C. P. Blobel
- Journal Title
  
  J Immunol 179
  
  Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591765
[Journal Article] TNFα-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock2007
- Author(s)
  Horiuchi K., Kimura T., Miyamoto T., Takaishi H., Okada Y., Toyama Y. and Blobel C. P
- Journal Title
  
  J. Immunol
  
  Volume: 179 Pages: 2686-2689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] Glioblastoma細胞におけるGINS複合体構成タンパク質の発現調節2016
- Author(s)
  木村徳宏, 石井文彩, 高倉伸幸, 河野裕夫, 池田栄二
- Organizer
  第105回日本病理学会総会
- Place of Presentation
  仙台国際センター（宮城県）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-26460434
[Presentation] HIF-1α陽性G0期腫瘍幹細胞からみた膠芽腫の腫瘍内微小環境2015
- Author(s)
  石井文彩、木村徳宏、貞廣浩和、河野裕夫、田久保圭誉、鈴木倫保、池田栄二
- Organizer
  第33回日本脳腫瘍病理学会
- Place of Presentation
  JRホテルクレメント高松（香川県）
- Year and Date
  2015-05-29
- Data Source
  KAKENHI-PROJECT-26460434
[Presentation] ヒト変形性関節症軟骨においてRECKは高発現し軟骨細胞のクローニングに関わる2012
- Author(s)
  木村徳宏、岡田愛子、谷田部拓、大久保匡、戸山芳昭、野田亮、岡田保典
- Organizer
  第25回日本軟骨代謝学会(招待講演)
- Place of Presentation
  ウィルあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-23790420
[Presentation] ヒト変形性関節症軟骨においてRECKは高発現し軟骨細胞のクローニングに関わる2012
- Author(s)
  木村徳宏, 岡田愛子, 谷田部拓, 大久保匡, 戸山芳昭, 野田亮, 岡田保典
- Organizer
  第25回日本軟骨代謝学会
- Place of Presentation
  ウィルあいち(愛知県)(招待講演)
- Year and Date
  2012-03-10
- Data Source
  KAKENHI-PROJECT-23790420
[Presentation] クローニング病変から見た関節軟骨変性の病態(シンポジウム軟骨エイジング-そのメカニズムと評価)2012
- Author(s)
  木村徳宏
- Organizer
  第40回日本関節病学会
- Place of Presentation
  鹿児島市民文化ホール(鹿児島県).(招待講演)
- Year and Date
  2012-11-09
- Data Source
  KAKENHI-PROJECT-23790420
[Presentation] 関節軟骨のリモデリング2011
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第57回日本病理学会秋期総会
- Place of Presentation
  東京・日本教育会館(招待講演)
- Data Source
  KAKENHI-PROJECT-19109004
[Presentation] 変形性関節症軟骨におけるSemaphorin 3Aの発現とVEGF165による軟骨細胞遊走における競合について2011
- Author(s)
  大久保匡、木村徳宏、藤田貴也、戸山芳昭、岡田保典
- Organizer
  第24回日本軟骨代謝学会
- Place of Presentation
  九州大学医学部(福岡県)
- Year and Date
  2011-03-04
- Data Source
  KAKENHI-PROJECT-21790364
[Presentation] Leishmania major感染に対する宿主免疫反応におけるmicroRNAシステムの機能解析(II)2011
- Author(s)
  田邊將信、木村徳宏、嘉陽啓之、下田耕治、気駕恒太朗、竹内勤、深尾太郎
- Organizer
  第80回日本寄生虫学会大会
- Place of Presentation
  東京都港区(慈恵医大)
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22590382
[Presentation] 関節軟骨のリモデリング(シンポジウム慢性炎症下における組織リモデリング)2011
- Author(s)
  木村徳宏, 岡田保典
- Organizer
  第57回日本病理学会秋期特別総会
- Place of Presentation
  日本教育会館(東京都)(招待講演)
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23790420
[Presentation] Leishmania major感染に対する宿主免疫反応におけるmicroRNAシステムの機能解析(II)2011
- Author(s)
  田邊將信、木村徳宏、嘉陽啓之、下田耕治、氣駕恒太朗、竹内勤、深尾太郎
- Organizer
  第80回日本寄生虫学会大会
- Place of Presentation
  東京都港区
- Year and Date
  2011-03-29
- Data Source
  KAKENHI-PROJECT-22590382
[Presentation] Leishmania major 感染に対する宿主免疫反応におけるmicroRNA システムの機能解析(II).2011
- Author(s)
  田邊將信、木村徳宏、嘉陽啓之、下田耕治、氣駕恒太朗、竹内勤、深尾太郎
- Organizer
  第80回日本寄生虫学会大会
- Place of Presentation
  東京都港区.
- Year and Date
  2011-07-17
- Data Source
  KAKENHI-PROJECT-22590382
[Presentation] Leishmania major 感染に対する宿主免疫反応におけるmicroRNA システムの機能解析.2010
- Author(s)
  田邊將信、木村徳宏、嘉陽啓之、下田耕治、竹内勤、深尾太郎
- Organizer
  第79回日本寄生虫学会大会
- Place of Presentation
  北海道旭川市.
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22590382
[Presentation] ヒト変形性関節症軟骨における、RECK分子による軟骨細胞の遊走・増殖調節2010
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第23回日本軟骨代謝学会
- Place of Presentation
  鹿児島県医師会館(鹿児島県)
- Year and Date
  2010-04-02
- Data Source
  KAKENHI-PROJECT-21790364
[Presentation] Leishmania major感染に対する宿主免疫反応におけるmicroRNAシステムの機能解析2010
- Author(s)
  田邊將信、木村徳宏、嘉陽啓之、下田耕治、竹内勤、深尾太郎
- Organizer
  第79回日本寄生虫学会大会
- Place of Presentation
  北海道旭川市
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-22590382
[Presentation] ヒト変形性関節症軟骨における膜結合型プロテアーゼインヒビターRECKの発現と機能2009
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第14回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-21790364
[Presentation] ヒト変形性関節症軟骨における膜結合型プロテアーゼインヒビターRECKの発現と機能2009
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第14回日本病態プロテアーゼ学会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府)
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-21790364
[Presentation] 変形性関節症関節軟骨におけるRECK分子の発現と機能解析2008
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第97回日本病理学会総会
- Place of Presentation
  石川県立音楽堂
- Year and Date
  2008-05-15
- Data Source
  KAKENHI-PROJECT-19790269
[Presentation] RECK分子はヒト変形性関節症軟骨に発現し軟骨細胞のcloningに関わる2008
- Author(s)
  木村徳宏、岡田保典
- Organizer
  第40回日本結合組織学会学術大会・第55回マトリックス研究会大会合同学術集会
- Place of Presentation
  こまばエミナース(東京都)
- Year and Date
  2008-05-30
- Data Source
  KAKENHI-PROJECT-19790269
[Presentation] クローニング病変から見た関節軟骨変性の病態
- Author(s)
  木村徳宏
- Organizer
  第40回日本関節病学会
- Place of Presentation
  鹿児島市民文化ホール
- Invited
- Data Source
  KAKENHI-PROJECT-23790420
[Presentation] 低酸素と腫瘍幹細胞―腫瘍切除標本からの考察
- Author(s)
  木村徳宏、石井文彩、池田栄二
- Organizer
  第103回日本病理学会総会
- Place of Presentation
  広島国際会議場・ANAクラウンプラザホテル広島（広島県）
- Year and Date
  2014-04-24 – 2014-04-26
- Invited
- Data Source
  KAKENHI-PROJECT-26460434
[Presentation] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity.
- Author(s)
  Chijiiwa M., Mochizuki S., Kimura T., Abe H., Tanaka Y., Fujii Y., Shimizu H., Enomoto H., Toyama. and Okada Y.
- Organizer
  Matrix Biology Europe 2014.
- Place of Presentation
  Rotterdam, Netherlands
- Year and Date
  2014-06-20 – 2014-06-24
- Data Source
  KAKENHI-PROJECT-24249022

1. OKADA Yasunori (00115221)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. IKEDA Eiji (30232177)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. MOCHIZUKI Satsuki (80365428)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. SHIMODA Masayuki (70383734)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. FUJII Yutaka (80211522)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. SASAKI Aya (60343381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FUJITA Yoshinari (10296642)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKAISHI Hironari (60236180)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. OKUBO Masashi (30445225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HORIUCHI Keisuke (30327564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. TOYAMA Yoshiaki (40129549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. MIYAMOTO Takeshi (70383768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. TANABE Masanobu (80051928)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. SHIMODA Koji (00129470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. FUKAO Taro (20401127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
16. 石井文彩 (50634747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
17. KIRAN Chada

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. JEANINE D' armiento

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 依田昌樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 小沢洋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KIMURA Tokuhiro 木村 徳宏

Research Projects

Research Products

Co-Researchers

Analysis of peri-necrotic microenvironment of glioblastoma via NFAT family transcription factorsPrincipal Investigator

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Analysis of pathophysiology of intratumoral microenvironments in glioblastoma using spheroid culture and histopathologyPrincipal Investigator

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Snailファミリーと軟骨細胞の遊走・分化に着目した変形性関節症の病態解析Principal Investigator

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Pathological study on metalloproteinases in tissue remodeling under pathological conditions

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Migratory potential of chondrocytes in human osteoarthritic cartilagePrincipal Investigator

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Analysis of the functions of microRNAs in host immune responses to infection with Leishmania major

Principal Investigator

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Expression and function of RECK in human osteoarthritic subchondral bone tissuePrincipal Investigator

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Functional analyses and regulation of the metabolism of tissue microenvironmental factors by metalloproteinases

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The regulation of vascularity by Semaphorin-3A in the osteo-cartilaginous tissues

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Studies of TACE in bone biology and inflammatory diseases

Principal Investigator

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Expression and function of RECK in human osteoarthritic cartilagePrincipal Investigator

Principal Investigator

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[Journal Article] Histological Characterization of the Tumorigenic "Peri-Necrotic Niche" Harboring Quiescent Stem-Like Tumor Cells in Glioblastoma.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CCN1 (Cyr61) is overexpressed in human osteoarthritic cartilage and inhibits ADAMTS4 (aggrecanase-1) activity.2015

Author(s)

Journal Title

Data Source

[Journal Article] Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones2013

KIMURA Tokuhiro 木村徳宏