Nishimura Shinichi 西村慎一

… Alternative Names

NISHIMURA Shinichi 西村慎一

西村慎一ニシムラシンイチ

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Researcher Number	30415260
Other IDs
External Links
Affiliation (Current)	2022: 東京大学, 大学院農学生命科学研究科(農学部), 講師
Affiliation (based on the past Project Information) *help	2018 – 2022: 東京大学, 大学院農学生命科学研究科(農学部), 講師 2016 – 2017: 京都大学, 薬学研究科, 助教 2011 – 2016: 京都大学, 薬学研究科(研究院), 助教 2013: 京都大学, 薬学研究科, 助教 2012: 京都大学, 大学院・薬学研究科, 助教 … More 2009 – 2010: Kyoto University, 薬学研究科, 助教 2007: The Institute of Physical and Chemical Research, 吉田化学遺伝学研究室, 基礎科学特別研究員 2006: 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 基礎科学特別研究員 Less
Review Section/Research Field	Principal Investigator Living organism molecular science / Science and Engineering / Biomolecular chemistry / Applied microbiology / Chemical biology / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 38040:Bioorganic chemistry-related / Medium-sized Section 38:Agricultural chemistry and related fields Except Principal Investigator Chemical biology / General physiology / Science and Engineering / Broad Section F / Medium-sized Section 38:Agricultural chemistry and related fields
Keywords	Principal Investigator 化学遺伝学 / 天然物化学 / 生体膜 / 膜脂質 / 分裂酵母 / 海洋天然物 / ケミカルジェネティクス / ケミカルゲノミクス / 代謝 / 脂質 … More / 生理活性化合物 / 化学ゲノミクス / 抗真菌化合物 / 脂質生物学 / 生育必須遺伝子 / 天然化合物 / 細胞形態 / 分子間相互作用 / 生体分子 / 共有結合 / 酵母変異株 / 組織的解析 / 再構築 / 天然物 / 生体膜脂質 / アミノ酸 / セリン / 免疫抑制剤 / ケミカルバイオロジー … More Except Principal Investigator ユビキチン / 脱ユビキチン化酵素 / activity-based probe / プローブ / 活性制御 / 酸化ストレス / ユビキチン様ドメイン / プロテアーゼ / アクティビティーベースドプローブ / プロテオミクス解析 / activety-based probe / システインプロテアーゼ / 化学コミュニケーション / 天然物化学 / 複合培養 / 生物活性リガンド / 生合成 / 内在性代謝物 / 化学遺伝学 / 創薬標的分子 / 翻訳後修飾 / 代謝フェロモン / 鉄代謝 / シデロフォア / 抗真菌抗生物質 / 微生物間コミュニケーション / ケミカルバイオロジー Less

マルチターゲットを有する膜脂質の化学オミクス解析Principal Investigator
- Principal Investigator
  
  西村慎一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  The University of Tokyo
セリン代謝の化学遺伝学的解析Principal Investigator
- Principal Investigator
  
  西村慎一
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  The University of Tokyo
Innovative chemical genetics on novel function of endogenous metabolites
- Principal Investigator
  
  吉田稔
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section F
- Research Institution
  Institute of Physical and Chemical Research
Chemical biology on siderophore-mediated inter-microbial interactions
- Principal Investigator
  
  吉田稔
- Project Period (FY)
  2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 38:Agricultural chemistry and related fields
- Research Institution
  Institute of Physical and Chemical Research
Identification of new natural products targeting cell membrane and analyses of their modes of action.Principal Investigator
- Principal Investigator
  
  Nishimura Shinichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  The University of Tokyo
Chemical communications in microbial interactions and development of useful bioactive ligands
- Principal Investigator
  
  掛谷秀昭
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Analysis of cell membrane environments targeted by marine natural productsPrincipal Investigator
- Principal Investigator
  
  Nishimura Shinichi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kyoto University
アミノ酸代謝を制御するハブ分子の多面性の理解に向けた天然物化学遺伝学Principal Investigator
- Principal Investigator
  
  西村慎一
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Development of chemical probes for linking small molecules and their receptors.Principal Investigator
- Principal Investigator
  
  NISHIMURA Shinichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Chemical genetics for understanding structure and function of cell membranesPrincipal Investigator
- Principal Investigator
  
  Nishimura Shinichi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Kyoto University
代謝と細胞形態のクロストークを解析する天然物リガンドの探索と作用機序解析Principal Investigator
- Principal Investigator
  
  西村慎一
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Kyoto University
Mechanism of unanchored polyubiquitin chain production
- Principal Investigator
  
  HATTORI Akira
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Kyoto University
Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics
- Principal Investigator
  
  HATTORI Akira
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical biology
- Research Institution
  Kyoto University
Chemical genomics using yeast essential genes for identifying target molecules/pathways of bioactive compoundsPrincipal Investigator
- Principal Investigator
  
  NISHIMURA Shinichi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied microbiology
- Research Institution
  Kyoto University
Chemical genetic research on cellular membrane using theonellamide.Principal Investigator
- Principal Investigator
  
  NISHIMURA Shinichi
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Kyoto University
分裂酵母の化学ゲノミクスによる生理活性物質の作用機序解明Principal Investigator
- Principal Investigator
  
  西村慎一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 細胞膜を撹乱する海洋天然物 -セオネラミドはステロールに結合し、異常な細胞壁合成を誘導する-.化学と生物. 492011
- Author(s)
  西村慎一, 掛谷秀昭, 吉田稔
- Data Source
  KAKENHI-PROJECT-23658077
[Journal Article] Genomic and Targeted Approaches Unveil the Cell Membrane as a Major Target of the Antifungal Cytotoxin Amantelide A2021
- Author(s)
  Elsadek, L.A., Matthews, J.H., Nishimura, S., Nakatani, T., Ito, A., Gu, T., Luo, D., Salvador-Reyes, L.A., Paul, V.J., Kakeya, H., Luesch, H.
- Journal Title
  
  ChemBioChem
  
  Volume: -
- DOI
  10.1002/cbic.202000685
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18K06717
[Journal Article] 天然物による細胞膜ステロールの分子認識と可視化への応用2021
- Author(s)
  西村慎一
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 32-35
- NAID
  40022520030
- Data Source
  KAKENHI-PROJECT-18K06717
[Journal Article] Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations2021
- Author(s)
  Kobayashi H, Hatakeyama H, Nishimura H, Yokota M, Suzuki S, Tomabechi Y, Shirouzu M, Osada H, Mimaki M, Goto YI, Yoshida M.
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 17 Pages: 335-343
- DOI
  10.1038/s41589-020-00676-4
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19K16728
[Journal Article] Amphiol, an Antifungal Fungal Pigment from Pseudogymnoascus sp. PF14642021
- Author(s)
  Fujita, K., Ikuta, M., Nishimura, S., Sugiyama, R., Yoshimura, A., Kakeya, H.
- Journal Title
  
  Journal of Natural Products
  
  Volume: -
- DOI
  10.1021/acs.jnatprod.0c01010
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18K06717
[Journal Article] Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products2021
- Author(s)
  Takenaka, K., Kaneko, K., Takahashi, N., Nishimura, S., Kakeya, H.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: -
- DOI
  10.1016/j.bmc.2021.116059
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06401
[Journal Article] A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells.2020
- Author(s)
  Kobayashi H, Nishimura H, Kudo N, Osada H, Yoshida M.
- Journal Title
  
  Biosci. Biotechnol. Biochem.
  
  Volume: 84 Pages: 2113-2120
- DOI
  10.1080/09168451.2020.1789445
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640
[Journal Article] Chemical diversity and mode of action of natural products targeting lipids in the eukaryotic cell membrane.2020
- Author(s)
  Nishimura, S. & Matsumori, N.
- Journal Title
  
  Natural Product Reports
  
  Volume: 37 Pages: 677-702
- DOI
  10.1039/c9np00059c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06717, KAKENHI-PROJECT-18K19149, KAKENHI-PUBLICLY-20H04781, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-20H00405
[Journal Article] Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast.2020
- Author(s)
  Kanou, A., Nishimura, S., Tabuchi, T., Matsuyama, A., Yoshida, M., Kato, T., Kakeya, H.
- Journal Title
  
  J. Antibiot (Tokyo)
  
  Volume: 73 Pages: 574-580
- DOI
  10.1038/s41429-020-0305-6
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-19H05640
[Journal Article] Theonellamide A, a marine-sponge-derived bicyclicpeptide,binds to sterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterolinteractions using hydroxylated cholesterol.2019
- Author(s)
  Cornelio Kimberly、Espiritu Rafael Atillo、Hanashima Shinya、Todokoro Yasuto、Malabed Raymond、Kinoshita Masanao、Matsumori Nobuaki、Murata Michio、Nishimura Shinichi、Kakeya Hideaki、Yoshida Minoru、Matsunaga Shigeki
- Journal Title
  
  Biochim. Biophys. Acta Biomembr.
  
  Volume: 1861 Pages: 228-235
- DOI
  10.1016/j.bbamem.2018.07.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19149, KAKENHI-PLANNED-17H06401, KAKENHI-PLANNED-17H06406, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-16H06315, KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-15H03121, KAKENHI-PROJECT-26221204
[Journal Article] Isolation, structure elucidation and conformational regulation of myropeptins, lipopeptides from a fungus Myrothecium rodium.2019
- Author(s)
  Yoshimura, A., Nishimura, S.*, Suzuki, T., Hattori, A., Dohmae, N., Kato, T. & Kakeya, H.
- Journal Title
  
  Org. Lett.
  
  Volume: 21 Pages: 7524-7528
- DOI
  10.1021/acs.orglett.9b02801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06717, KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-19H02840
[Journal Article] ビーチまで徒歩10秒．スクリプス海洋研究所で天然物化学を考える．2019
- Author(s)
  西村慎一
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 29 Pages: 8-12
- NAID
  130007981710
- Data Source
  KAKENHI-PROJECT-18K06717
[Journal Article] Identification of the common biosynthetic gene cluster forboth antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines2019
- Author(s)
  Ozaki Taro、Sugiyama Ryosuke、Shimomura Morito、Nishimura Shinichi、Asamizu Shumpei、Katsuyama Yohei、Kakeya Hideaki、Onaka Hiroyasu
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 17 Pages: 2370-2378
- DOI
  10.1039/c8ob02846j
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05385, KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-17K19233, KAKENHI-PLANNED-16H06444
[Journal Article] Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation.2019
- Author(s)
  Sugiyama Ryosuke、Nakatani Takahiro、Nishimura Shinichi、Takenaka Kei、Ozaki Taro、Asamizu Shumpei、Onaka Hiroyasu、Kakeya Hideaki
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 58 Pages: 13486-13491
- DOI
  10.1002/anie.201905970
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05385, KAKENHI-PROJECT-18K06717, KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-18H02120, KAKENHI-PROJECT-19H02840
[Journal Article] 生体膜を標的にする天然有機化合物 -天然物による厳密な脂質認識とそれに基づく表現型-2018
- Author(s)
  西村慎一, 掛谷秀昭 & 松森信明.
- Journal Title
  
  化学と生物
  
  Volume: 56 Pages: 678-685
- NAID
  130007709540
- Data Source
  KAKENHI-PROJECT-18K06717
[Journal Article] 生体膜を標的にする天然有機化合物：天然物による厳密な脂質認識とそれに基づく表現型2018
- Author(s)
  西村慎一, 掛谷秀昭, 松森信明
- Journal Title
  
  化学と生物
  
  Volume: 56 Pages: 678-685
- NAID
  130007709540
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06401
[Journal Article] Discovery of presaccharothriolide X, a retro-Michael product of saccharothriolide B, from the rare actinomycete Saccharothrix sp. A15062018
- Author(s)
  Shan Lu, Shinichi Nishimura, Kei Takenaka, Masashi Ito, Taira Kato, Hideaki Kakeya
- Journal Title
  
  Org. Lett.
  
  Volume: 20 Pages: 4406-4410
- DOI
  10.1021/acs.orglett.8b01535
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-17H06401, KAKENHI-PROJECT-17K19233
[Journal Article] Precursor-directed in situ synthesis of saccharothriolides G and H by the actinomycete Saccharothrix sp.2017
- Author(s)
  Shan Lu, Shinich Nishimura, Masashi Ito, Taira Kato, Hideaki Kakeya
- Journal Title
  
  J. Antibiot.
  
  Volume: 70 Pages: 718-720
- DOI
  10.1038/ja.2016.153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19233, KAKENHI-PLANNED-17H06401
[Journal Article] Stereochemical assignment and biological evaluation of BE-14106 unveils the importance of one acetate unit for the antifungal activity of polyene macrolactams.2016
- Author(s)
  Fujita, K.; Sugiyama, R.; Nishimura, S.; Ishikawa, N.; Arai, M. A.; Ishibashi, M.; Kakeya, H.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 79 Pages: 1877-1880
- DOI
  10.1021/acs.jnatprod.6b00250
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04650, KAKENHI-PROJECT-25702048
[Journal Article] Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores2016
- Author(s)
  1.Espiritu, R. A., Cornelio, K., Kinoshita, M., Matsumori, N., Murata, M., Nishimura, S., Kakeya, H., Yoshida, M. & Matsunaga, S.
- Journal Title
  
  Biochem. Biophys. Acta
  
  Volume: 1858 Pages: 1373-1379
- DOI
  10.1016/j.bbamem.2016.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-26102726, KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H03121, KAKENHI-PROJECT-25702048
[Journal Article] Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by 1H NMR.2016
- Author(s)
  Kimberly Cornelio, Rafael Atillo Espiritu, Yasuto Todokoro, Shinya Hanashima, Masanao Kinoshita, Nobuaki Matsumori, Michio Murata, Shinichi Nishimura, Hideaki Kakeya, Minoru Yoshida, Shigeki Matsunaga
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Pages: 5235-5242
- DOI
  10.1016/j.bmc.2016.08.043
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-16H00773, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H03121, KAKENHI-PROJECT-25702048
[Journal Article] Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent2016
- Author(s)
  Satoe Takahashi, Kazuaki Homma, Yingjie Zhou, Shinichi Nishimura, Chongwen Duan, Jessie Chen, Aisha Ahmad, Mary Ann Cheatham & Jing Zheng
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 21973-21973
- DOI
  10.1038/srep21973
- NAID
  120005818274
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25702048
[Journal Article] Discovery and total synthesis of streptoaminals, antimicrobial [5,5]-spirohemiaminals from the combined-culture of Streptomyces nigrescens and Tsukamurella pulmonis.2016
- Author(s)
  Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H.
- Journal Title
  
  Angew. Chem. Int. Ed.
  
  Volume: 55(35) Pages: 10278-10282
- DOI
  10.1002/anie.201604126
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-25702048, KAKENHI-PROJECT-15K14721, KAKENHI-PROJECT-16K18673
[Journal Article] Tetherin is an exosomal tether.2016
- Author(s)
  Edgar, J.R., Manna, P.T., Nishimura, S., Banting, G. & Robinson, M.S.
- Journal Title
  
  eLife
  
  Volume: 5
- DOI
  10.7554/elife.17180
- NAID
  120005997859
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25702048
[Journal Article] Asymmetric total synthesis of heronamides A-C: stereochemical confirmation and impact of long-range stereochemical communication on the biological activity.2016
- Author(s)
  Kanoh, N., Itoh, S., Fujita, K., Sakanishi, K., Sugiyama, R., Terajima, Y., Iwabuchi, Y., Nishimura, S. & Kakeya, H.
- Journal Title
  
  Chem. Eur. J.
  
  Volume: 22 Pages: 8586-8595
- DOI
  10.1002/chem.201600569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25702048
[Journal Article] 5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites, produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonis.2015
- Author(s)
  Sugiyama R, Nishimura S, Ozaki T, Asamizu S, Onaka H, Kakeya H.
- Journal Title
  
  Org. Lett.
  
  Volume: 印刷中 Pages: 1918-1921
- DOI
  10.1021/acs.orglett.5b00607
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25292046, KAKENHI-PROJECT-25702048, KAKENHI-PUBLICLY-26102726, KAKENHI-PROJECT-26850044, KAKENHI-PROJECT-15K14721
[Journal Article] Structure elucidation of verucopeptin, a potent HIF-1 inhibitory polyketide-hexapeptide hybrid metabolite from an actinomycete.2015
- Author(s)
  2.Yoshimura, A., Nishimura, S., Otsuka, S., Hattori, A. & Kakeya, H.
- Journal Title
  
  Org. Lett.
  
  Volume: 17 Pages: 5364-5367
- DOI
  10.1021/acs.orglett.5b02718
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26102726
[Journal Article] 生体膜微小環境への挑戦：膜ステロールに作用する海洋天然物セオネラミド2015
- Author(s)
  西村慎一, 掛谷秀昭
- Journal Title
  
  CSJカレントレビュー「生物活性分子のケミカルバイオロジー」
  
  Volume: 19 Pages: 102-108
- Data Source
  KAKENHI-PUBLICLY-26102726
[Journal Article] In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes2015
- Author(s)
  Akihiro Moriyama, Naohiro Katagiri, Shinichi Nishimura, Nobuaki Takahashi & Hideaki Kakeya
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 17427-17427
- DOI
  10.1038/srep17427
- NAID
  120005708010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25702048
[Journal Article] Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.2015
- Author(s)
  3.Lu, S., Nishimura, S., Hirai, G., Ito, M., Kawahara, T., Izumikawa, M., Sodeoka, M., Shin-ya, K., Tsuchida, T. & Kakeya, H.
- Journal Title
  
  Chem Commun
  
  Volume: 51 Pages: 8074-8077
- DOI
  10.1039/c5cc01953b
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-26102726
[Journal Article] ステロール標的抗真菌剤の活性発現における細胞膜輸送バランスの重要性2015
- Author(s)
  西村慎一 & 掛谷秀昭
- Journal Title
  
  バイオサイエンスとインダストリー
  
  Volume: 73 Pages: 383-385
- NAID
  40020591850
- Data Source
  KAKENHI-PUBLICLY-26102726
[Journal Article] 生体膜微小環境への挑戦：膜ステロールに作用する海洋天然物セオネラミド2015
- Author(s)
  西村慎一, 掛谷秀昭
- Journal Title
  
  CSJカレントレビュー「生物活性分子のケミカルバイオロジー」
  
  Volume: 19 Pages: 102-108
- Data Source
  KAKENHI-PROJECT-25702048
[Journal Article] Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes2014
- Author(s)
  Sugiyama, R., Nishimura, S., Matsumori, N., Tsunematsu, Y., Hattori, A. & Kakeya, H.
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 136 Pages: 5209-5212
- DOI
  10.1021/ja500128u
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102515, KAKENHI-PUBLICLY-24102517, KAKENHI-PROJECT-25702048
[Journal Article] Total synthesis of the proposed structure of heronamide C.2014
- Author(s)
  K. Sakanishi, S. Itoh, R. Sugiyama, S. Nishimura, H. Kakeya, Y. Iwabuchi, N. Kanoh
- Journal Title
  
  Eur. J. Org. Chem.
  
  Volume: なし Pages: 1376-1380
- DOI
  10.1002/ejoc.201301487
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23102013, KAKENHI-PUBLICLY-24102515, KAKENHI-PROJECT-25702048
[Journal Article] Balance between exocytosis and endocytosis determines the efficacy of sterol-targeting antibiotics2014
- Author(s)
  Nishimura, S., Tokukura, M., Ochi, J., Yoshida, M. & Kakeya H.
- Journal Title
  
  Chemistry & Biology
  
  Volume: 21 Pages: 1690-1699
- DOI
  10.1016/j.chembiol.2014.10.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25702048, KAKENHI-PUBLICLY-26102726, KAKENHI-PROJECT-26221204
[Journal Article] Chemical tagging of a drug target using 5-sulfonyl tetrazole.2013
- Author(s)
  Otsuki S, Nishimura S, Takabatake H, Nakajima K, Takasu Y, Yagura T, Sakai Y, Hattori A, & Kakeya H
- Journal Title
  
  Bioorg Med Chem. Lettt.
  
  Volume: 23 Pages: 1608-1611
- DOI
  10.1016/j.bmcl.2013.01.092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099, KAKENHI-PROJECT-221S0001
[Journal Article] Interaction between the Marine Sponge Cyclic Peptide Theonellamide A and Sterols in Lipid Bilayers as Viewed by Surface Plasmon Resonance and Solid State 2H NMR.2013
- Author(s)
  Espiritu, R. A., Matsumori, N., Murata, M., Nishimura, S., Kakeya, H., Matsunaga, S. & Yoshida, M.
- Journal Title
  
  Biochemistry.
  
  Volume: 52 Pages: 2410-2418
- DOI
  10.1021/bi4000854
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102515, KAKENHI-PROJECT-25242073, KAKENHI-PROJECT-25702048, KAKENHI-PUBLICLY-24102517
[Journal Article] Visualization of sterol-rich membrane domains with fluorescently-labeled theonellamides2013
- Author(s)
  Nishimura, S., Ishii, K., Iwamoto, K., Matsunaga, S., Ohno-Iwashita, Y., Sato, S. B., Kakeya, H., Kobayashi, T. & Yoshida, M.
- Journal Title
  
  PLoS ONE
  
  Volume: 8
- DOI
  10.1371/journal.pone.0083716
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-24102515, KAKENHI-PROJECT-24657143, KAKENHI-PROJECT-25702048
[Journal Article] RNA-methylation-dependent RNA processing controls the speed of the circadian clock.2013
- Author(s)
  Fustin JM, Doi M, Yamaguchi Y, Hayashi H, Nishimura S, Yoshida M, Isagawa T, Suimye-Morioka M, Kakeya H, Manabe I, Okamura H
- Journal Title
  
  Cell
  
  Volume: 155 Pages: 793-806
- DOI
  10.1016/j.cell.2013.10.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01412, KAKENHI-PROJECT-21228003, KAKENHI-PROJECT-23590107, KAKENHI-PUBLICLY-24102515, KAKENHI-PUBLICLY-24111526, KAKENHI-PROJECT-24240058, KAKENHI-PROJECT-25560426
[Journal Article] Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp2012
- Author(s)
  Kishimoto S, Tsunematsu Y, Nishimura S, Hayashi Y, Hattori A, & Kakeya H
- Journal Title
  
  Tetrahedron
  
  Volume: 68 Pages: 5572-5578
- DOI
  10.1016/j.tet.2012.04.075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310160, KAKENHI-PROJECT-24659099
[Journal Article] 細胞膜を撹乱する海洋天然物-セオネラミドはステロールに結合し、異常な細胞壁合成を誘導する-2011
- Author(s)
  西村慎一, 掛谷秀昭, 吉田稔
- Journal Title
  
  化学と生物 49
  
  Pages: 295-297
- NAID
  10028273145
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] プロファイリングによる化合物の作用解析-セオネラミドの細胞内標的はステロールだった-2011
- Author(s)
  西村慎一、吉田稔
- Journal Title
  
  化学
  
  Volume: 66 Pages: 51-56
- NAID
  40017430640
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] 細胞膜を撹乱する海洋天然物-セオネラミドはステロールに結合し、異常な細胞壁合成を誘導する-2011
- Author(s)
  西村慎一、掛谷秀昭、吉田稔
- Journal Title
  
  化学と生物
  
  Volume: (印刷中)
- NAID
  10028273145
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] プロファイリングによる化合物の作用解析2011
- Author(s)
  西村慎一, 吉田稔
- Journal Title
  
  化学 66
  
  Pages: 51-56
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] Marine antifungal theonellamides target 3β-hydroxysterol toactivate Rho1 signaling.2010
- Author(s)
  Nishimura, S., et al.
- Journal Title
  
  Nat.Chem.Biol. 6
  
  Pages: 519-526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] 新規有用天然有機化合物の開拓とケミカルバイオロジー研究2010
- Author(s)
  掛谷秀昭, 西村慎一
- Journal Title
  
  有機合成化学協会誌 68
  
  Pages: 490-500
- NAID
  10026868928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] 新規有用天然有機化合物の開拓とケミカルバイオロジー研究2010
- Author(s)
  掛谷秀昭、西村慎一
- Journal Title
  
  有機合成化学協会誌
  
  Volume: 68 Pages: 490-500
- NAID
  10026868928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling.2010
- Author(s)
  Shinichi Nishimura, et al.
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 6 Pages: 519-526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710227
[Journal Article] 酵母を基盤としたケミカルゲノミクス2006
- Author(s)
  西村慎一
- Journal Title
  
  BIONICS 23
  
  Pages: 39-45
- Data Source
  KAKENHI-PROJECT-18710194
[Journal Article] Marine antifungal theonellamides target 3β-hydroxysterol to activate Rhol signaling
- Author(s)
  Shinichi Nishimura
- Journal Title
  
  Nature Chemical Biology (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21710227
[Patent] 新規生物活性物質2014
- Inventor(s)
  掛谷秀昭、西村慎一、服部明、岸本真治、波多野和樹、五十嵐雅之
- Industrial Property Rights Holder
  掛谷秀昭、西村慎一、服部明、岸本真治、波多野和樹、五十嵐雅之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-041703
- Filing Date
  2014-03-04
- Data Source
  KAKENHI-PUBLICLY-24102515
[Patent] 新規抗真菌剤2012
- Inventor(s)
  掛谷秀昭、西村慎一、杉山龍介、尾仲宏康
- Industrial Property Number
  2012-170361
- Filing Date
  2012-07-31
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] 奇数鎖脂肪酸は分裂酵母において細胞膜極性と細胞分裂に異常を引き起こす．2021
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Li Sheena、八代田陽子、Boone Charles、吉田稔．
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 分裂酵母における窒素源としてのアミノ酸選択機構の解析2021
- Author(s)
  田渕稔二、西村慎一、松山晃久、吉田稔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] ステロール標的型天然物を用いた細胞極性とステロールの関係性の探索2021
- Author(s)
  中尾拳典、菅長昭文、西村慎一、松山晃久、吉田稔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] ステロール標的型天然物を用いた細胞極性とステロールの関係性の探索．2021
- Author(s)
  中尾拳典、菅長昭文、西村慎一、松山晃久、吉田稔．
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 機能低下したミトコンドリアを活性化させる化合物の発見とその応用2021
- Author(s)
  小林大貴、畠山英之、伊藤孝、西村はる菜、横田睦美、鈴木禎史、苫米地由里、白水美香子、長田裕之、三牧正和、後藤雄一、吉田稔
- Organizer
  J-mit 特別オンラインシンポジウム
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 糸状菌Acremonium persicinumが産生する抗真菌化合物ASP2397の生合成遺伝子の同定とシデロフォア機能の解析2021
- Author(s)
  浅井良樹、西村慎一、平塚知成、河村優美、吉田稔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 奇数鎖脂肪酸は分裂酵母において細胞膜極性と細胞分裂に異常を引き起こす2021
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Li Sheena、八代田陽子、Boone Charles、吉田稔
- Organizer
  日本農芸化学会2021年度大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 炭素鎖長15の脂肪酸とそのモノアシルグリセロールは分裂酵母の細胞分裂異常を引き起こす2020
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、Charles Boone、吉田稔
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 細胞膜ステロールを標的にする抗真菌化合物が引き起こす細胞壁異常の分子機構解析2020
- Author(s)
  西村慎一
- Organizer
  第93回日本生化学会大会シンポジウム「代謝物再興:生命機能におけるエピゲノムとダイナミズムの制御因子」
- Invited
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 奇数鎖脂肪酸は分裂酵母において細胞分裂異常を引き起こす2020
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、Charles Boone、吉田稔
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 生体膜を標的にする抗真菌化合物の探索と作用機序に関する研究2020
- Author(s)
  西村慎一
- Organizer
  メディカルサイエンスセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 生体膜を標的にする抗真菌化合物の探索と作用機序に関する研究.2020
- Author(s)
  西村慎一.
- Organizer
  メディカルサイエンスセミナー.
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 奇数鎖脂肪酸は分裂酵母において細胞分裂異常を引き起こす．2020
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、Charles Boone、吉田稔．
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 分裂酵母Schizosaccharomyces pombeにおけるセリン代謝制御機構の化学遺伝学的解析2020
- Author(s)
  佐々木舞、西村慎一、松山晃久、八代田陽子、掛谷秀昭、吉田稔
- Organizer
  第20回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 分裂酵母における栄養源感受性変異株の探索と解析2020
- Author(s)
  三浦俊一、八代田陽子、西村慎一、松山晃久、吉田稔
- Organizer
  日本農芸化学会2020年度大会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 分裂酵母の細胞間コミュニケーションにおけるシデロフォアの機能解析2020
- Author(s)
  中村優里、西村慎一、松山晃久、吉田稔
- Organizer
  第20回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 炭素鎖長15の脂肪酸とそのモノアシルグリセロール体は分裂酵母の細胞分裂異常を引き起こす．2020
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、Charles Boone、吉田稔．
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 奇数鎖脂肪酸は分裂酵母において細胞分裂異常を引き起こす2020
- Author(s)
  星川陽次郎、西村慎一、松山晃久、Sheena Li、八代田陽子、Charles Boone、吉田稔
- Organizer
  第20回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 細胞膜ステロールを標的にする抗真菌化合物が引き起こす細胞壁異常の分子機構解析．2020
- Author(s)
  西村慎一．
- Organizer
  第93回日本生化学会大会シンポジウム「代謝物再興：生命機能におけるエピゲノムとダイナミズムの制御因子」
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] Chemical Interactions of Actinomycete Metabolite 5-Alkyl-1,2,3,4-tetrahydroquinolines through Aggregate Formation.2020
- Author(s)
  Shinichi Nishimura, Ryosuke Sugiyama, Takahiro Nakatani, Kei Takenaka, Taro Ozaki, Shumpei Asamizu, Hiroyasu Onaka, & Hideaki Kakeya.
- Organizer
  Gordon Research Conference -Marine Natural Products-
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 微生物二次代謝物のインタープレイ2019
- Author(s)
  西村慎一
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」第４回若手シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] Comprehensive analysis of the mechanism of action of theonellamides, marine-derived antifungals, based on fission yeast ORFeome2019
- Author(s)
  Shinichi Nishimura, Akifumi Suganaga, Akihisa Matsuyama, Minoru Yoshida
- Organizer
  2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] ステロールの機能変調により局在変化を受ける分裂酵母タンパク質の網羅的探索．2019
- Author(s)
  西村慎一、菅長昭文、松山晃久、吉田稔．
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] Chemical genetic analysis of sterol-regulated proteins using fission yeast ORFeome2019
- Author(s)
  Nishimura, S., Suganaga, A., Matsuyama, A Yoshida, M
- Organizer
  10th International Fission Yeast Meeting (Pombe meeting 2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 糸状菌Acremonium persicinumにおけるシデロフォア型抗真菌化合物ASP2397の生産機構の解析2019
- Author(s)
  浅井良樹，西村慎一，平塚知成，河村優美，吉田稔
- Organizer
  第19回糸状菌分子生物学コンファレンス
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] Comprehensive analysis of the mechanism of action of theonellamides, marine-derived antifungals, based on fission yeast ORFeome.2019
- Author(s)
  Shinichi Nishimura, Akifumi Suganaga, Akihisa Matsuyama & Minoru Yoshida.
- Organizer
  Cold Spring Harbor Asia Conference, Chemical Biology & Drug Discovery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 海洋天然物セオネラミドを用いた生体膜脂質の機能解析．2019
- Author(s)
  西村慎一．
- Organizer
  第７回バイオ関連化学シンポジウム若手フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 特殊脂肪酸とそのモノアシルグリセロール体が示す抗真菌活性の作用機序の解明．2019
- Author(s)
  星川陽次郎、西村慎一、Sheena Li、八代田陽子、Charles Boone、吉田稔．
- Organizer
  第19回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] ステロールの機能変調により局在変化を受ける分裂酵母タンパク質の網羅的探索2019
- Author(s)
  西村慎一、菅長昭文、松山晃久、吉田稔
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19H05640
[Presentation] 分裂酵母ORFeomeを利用した海洋天然物セオネラミドの作用機序研究．2019
- Author(s)
  菅長昭文、西村慎一、松山晃久、吉田稔．
- Organizer
  第19回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] Chemical genetic analysis of sterol-regulated proteins using fission yeast ORFeome.2019
- Author(s)
  Shinichi NISHIMURA, Akifumi SUGANAGA, Akihisa MATSUYAMA & Minoru YOSHIDA.
- Organizer
  10th International Fission Yeast Meeting Pombe 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] ステロールを標的にする抗真菌化合物セオネラミドによる細胞壁異常．2019
- Author(s)
  西村慎一, 菅長昭文, 松山晃久, 吉田稔, 徳倉将人, 掛谷秀昭 , 松永茂樹, 大隅正子, 生瀬義久, Vanessa S. D. Carvalho, Juan C. G. Cortes, Juan. C. Ribas.
- Organizer
  綜合画像研究支援（IIRS）創立十五周年記念シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 海洋天然物セオネラミドによるステロールの可視化と機能変調2019
- Author(s)
  西村慎一
- Organizer
  日本農芸化学会2019年度大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 放線菌代謝産物5aTHQが示す膜親和性2018
- Author(s)
  西村慎一
- Organizer
  第9回発酵学フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 分裂酵母をもちいた生体膜標的型分子の探索と機能解析2018
- Author(s)
  西村慎一
- Organizer
  第194回酵母細胞研究会例会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] Expansion of chemical space in saccharothriolides: Precursor-directed in situ synthesis (PDSS) in a rare actinomycete Saccharothrix sp2018
- Author(s)
  Shan Lu, Shinichi Nishimura, Masashi Ito, Taira Kato, Hideaki Kakeya
- Organizer
  Natural Product Discovey & Development in the Genomic Era (Natural Products 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06401
[Presentation] 真菌膜脂質の機能攪乱分子を用いたケミカルバイオロジー：於京都 -> サンディエゴ -> 東京2018
- Author(s)
  西村慎一
- Organizer
  第29回　新薬創製談話会
- Invited
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] 微生物の複合培養で得られる5aTHQの膜親和性と生物活性. 第60回天然有機化合物討論会2018
- Author(s)
  西村慎一, 杉山龍介, 仲谷崇宏, 尾崎太郎, 浅水俊平, 尾仲宏康, 掛谷秀昭
- Organizer
  第60回天然有機化合物討論会（福岡）
- Data Source
  KAKENHI-PLANNED-17H06401
[Presentation] 微生物の複合培養で得られる5aTHQの膜親和性と生物活性．2018
- Author(s)
  西村慎一、杉山龍介、仲谷崇宏、尾崎太郎、浅水俊平、尾仲宏康、掛谷秀昭．
- Organizer
  第60回　天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-18K06717
[Presentation] Aggregate formation and lipid-related activity of 5aTHQs, cryptic actinomycete metabolites2018
- Author(s)
  Shinichi Nishimura, Ryosuke Sugiyama, Takahiro Nakatani, Taro Ozaki, Shumpei Asamizu, Hiroyasu Onaka, Hideaki Kakeya
- Organizer
  日本化学会年会　Asian International Symposium -Medicinal Chemistry-
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K13086
[Presentation] 微生物間化学コミュニケーションの理解と有用生物活性リガンドの開発2018
- Author(s)
  掛谷秀昭, 西村慎一, 倉永健史, 野中元裕, 井本正哉
- Organizer
  新学術領域研究「化学コミュニケーションのフロンティア」・第3回公開シンポジウム（東京）
- Data Source
  KAKENHI-PLANNED-17H06401
[Presentation] 多隔壁形成や細胞伸長におけるスフィンゴ脂質の重要性2018
- Author(s)
  生田実沙, 伊藤愛理, 西村慎一, 吉田稔, 掛谷秀昭
- Organizer
  酵母遺伝学フォーーラム第51回研究報告会（福岡）
- Data Source
  KAKENHI-PLANNED-17H06401
[Presentation] 放線菌のクリプティック代謝物5aTHQによる凝集体形成と脂質関連活性2017
- Author(s)
  西村慎一
- Organizer
  京都大学　生理化学研究ユニット　第7回シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K13086
[Presentation] スフィンゴ脂質の機能解明を目指した化学遺伝学的解析：エキノマイシン類の取得とその表現型2017
- Author(s)
  生田実沙, 伊藤愛理, 西村慎一, 掛谷秀昭
- Organizer
  酵母遺伝学フォーラム　第50回研究報告会
- Data Source
  KAKENHI-PROJECT-16K13086
[Presentation] ステロールを標的にする抗真菌化合物セオネラミドによる細胞壁異常2017
- Author(s)
  西村慎一、徳倉将人、掛谷秀昭、松永茂樹、大隅正子、生瀬義久、Vanessa S. D. Carvalho、 Juan C. G. Cortes、Juan. C. Ribas
- Organizer
  酵母遺伝学フォーラム　第50回研究報告会
- Data Source
  KAKENHI-PROJECT-16K13086
[Presentation] サポニンとステロールの分子間相互作用における炭化水素平面と水酸基の重要性2017
- Author(s)
  西村慎一、伊藤愛理、高橋伸明、掛谷秀昭
- Organizer
  日本ケミカルバイオロジー学会第 12 回年会
- Data Source
  KAKENHI-PROJECT-16K13086
[Presentation] 生体膜に着目した天然有機化合物の機能開拓2016
- Author(s)
  西村慎一
- Organizer
  第4回関西バイオ創薬研究会
- Place of Presentation
  大阪
- Invited
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] Strict recognition of membrane lipids by a sea cucumber saponin, holotoxin B2016
- Author(s)
  Nishimura, S., Ito, A., Kakeya, H.
- Organizer
  Gordon Research Conference-Marine Natural Products-
- Place of Presentation
  Ventura, CA, USA
- Year and Date
  2016-03-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] 微生物の複合培養で得られる5aTHQとstreptoaminalの構造と機能2016
- Author(s)
  西村慎一, 杉山龍介, 仲谷崇宏, 尾崎太郎, 浅水俊平, 尾仲宏康, 掛谷秀昭
- Organizer
  第21回天然薬物の開発と応用シンポジウム
- Place of Presentation
  千葉
- Year and Date
  2016-10-27
- Invited
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] In vivo linking of membrane lipids and membrane proteins using amphiphilic lipid probes2016
- Author(s)
  Nishimura, S., Moriyama, A., Katagiri, N., Takahashi, N., Kakeya, H.
- Organizer
  The 8th Takeda Science Foundation Symposium on PharmaSciences: Biomolecule-Based Medicinal Science: Featuring Mid-Size Drugs
- Place of Presentation
  Osaka, Japan
- Year and Date
  2016-01-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] 生体膜と相互作用する5aTHQ類の構造活性相関と蛍光プローブ開発2016
- Author(s)
  仲谷崇宏、杉山龍介、西村慎一、掛谷秀昭
- Organizer
  日本ケミカルバイオロジー学会　第11回年会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] Structure and function of heronamides, polyene macrolactams from marine-derived actinomycetes2015
- Author(s)
  Nishimura, S., Sugiyama, R., Fujita, K., Ito, S., Sakanishi, K., Iwabuchi, Y., Kanoh, N., Matsumori, N., Kakeya, H.
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (PACIFICHEM 2015)
- Place of Presentation
  Honolulu, HA, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] 5-Alkyl-1,2,3,4-tetrahydroquinolines (5aTHQs), new membrane-interacting lipophilic metabolites, produced by combined-culture of Streptomyces nigrescens and Tsukamurella pulmonis.2015
- Author(s)
  Sugiyama, R., Nishimura, S., Ozaki, T., Asamizu, S., Onaka, H., Kakeya, H.
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (PACIFICHEM 2015)
- Place of Presentation
  Honolulu, HA, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-26102726
[Presentation] Sterol-targeting antibiotics and the balance of membrane trafficking2015
- Author(s)
  Nishimura, S., Kakeya, H.
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015 (PACIFICHEM 2015)
- Place of Presentation
  Honolulu, HA, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] Abnormal cell wall deposition by heronamides, small molecules targeting phospholipids possessing saturated hydrocarbon chain2015
- Author(s)
  Nishimura, S., Sugiyama, R., Fujita, K., Kakeya, H
- Organizer
  Pombe 2105 (8th International Fission Yeast Meeting)
- Place of Presentation
  Kobe, Japan
- Year and Date
  2015-06-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] Mode of action of heronamides, polyene macrolactams from marine-derived Streptomyces sp.2014
- Author(s)
  Nishimura, S.
- Organizer
  Gordon Research Conference-Marine Natural Products-
- Place of Presentation
  CA, USA
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] Mode of action of heronamides, polyene macrolactams from marine-derived Streptomyces sp.2014
- Author(s)
  Nishimura, S.
- Organizer
  Gordon Research Conference-Marine Natural Products-
- Place of Presentation
  CA, USA
- Data Source
  KAKENHI-PUBLICLY-24102515
[Presentation] Sterol-rich membrane domains and the balance of membrane traffic2013
- Author(s)
  Nishimura, S., Tokukura, M., Ochi, J., Yoshida, M. & Kakeya, H.
- Organizer
  7th International fission Yeast Meeting
- Place of Presentation
  London, UK
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] Sterol-rich membrane domains and the balance of membrane traffic2013
- Author(s)
  Nishimura, S., Tokukura, M., Ochi, J., Yoshida, M. & Kakeya, H.
- Organizer
  7th International fission Yeast Meeting
- Place of Presentation
  London, UK
- Data Source
  KAKENHI-PUBLICLY-24102515
[Presentation] 抗生物質が好む生体膜の解析2013
- Author(s)
  西村慎一、徳倉将人、越智純子、吉田稔 & 掛谷秀昭.
- Organizer
  第6回北陸合同バイオシンポジウム
- Place of Presentation
  石川
- Data Source
  KAKENHI-PROJECT-25702048
[Presentation] 放線菌が生産する新規テトラヒドロキノリン誘導体の単離・構造解析.2012
- Author(s)
  杉山龍介, 西村慎一, 森夕希子, 尾仲宏康, 掛谷秀昭
- Organizer
  日本薬学会第132 年会
- Place of Presentation
  札幌市.
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] 生体膜を解析する化学遺伝学2012
- Author(s)
  西村慎一、掛谷秀昭
- Organizer
  日本薬学会第132 年会シンポジウム-天然物化学の新しい潮流-
- Place of Presentation
  札幌市
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] 放線菌の複合培養によって得られる新規テトラヒドロキノリン誘導体に関する研究2012
- Author(s)
  杉山龍介、西村慎一、森夕希子、尾仲宏康、掛谷秀昭.
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都市
- Year and Date
  2012-06-07
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] 生体膜を解析する化学遺伝学．2012
- Author(s)
  西村慎一，掛谷秀昭
- Organizer
  日本薬学会第132年会シンポジウム -天然物化学の新しい潮流-(招待講演)
- Place of Presentation
  北海道大学（北海道）
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] 分裂酵母における細胞膜ステロールの局在制御の解析2011
- Author(s)
  越智純子, 西村慎一, 掛谷秀昭.
- Organizer
  酵母遺伝学フォーラム・第44回研究報告会
- Place of Presentation
  福岡市
- Year and Date
  2011-09-05
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] Marine natural products targeting cellular membrane.2011
- Author(s)
  Shinichi Nishimura
- Organizer
  7th U.S.-Japan Seminar on Marine Natural Products: Cross-Discipllinary Expansions in Marine Bioorganic Chemistry(招待講演)
- Place of Presentation
  沖縄コンベンションセンター（沖縄）
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] Marine natural products targeting cellular membrane.2011
- Author(s)
  Nishimura, S.
- Organizer
  7th U.S.-Japan Seminar on Marine Natural Products: Cross-Disciplinary Expansions in Marine Bioorganic Chemistry.
- Place of Presentation
  Okinawa, Japan.
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-23658077
[Presentation] 海産抗真菌物質theonellamideの作用機序解明2010
- Author(s)
  西村慎一, et al.
- Organizer
  日本薬学会近畿支部会
- Place of Presentation
  摂南大学(大阪府)
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] Modes of action oftheonellamides, antifungal bicyclicpeptides from a marine sponge.2010
- Author(s)
  Nishimura, S., Matsunaga, S., Kakeya,H., Yoshida, M.
- Organizer
  Pacifichem2010
- Place of Presentation
  Hawaii,U.S.A.
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] ステロールを標的とするtheonellamideの作用機序解析2010
- Author(s)
  西村慎一, 越智順子, 有田裕子, 松山晃久, 松永茂樹, 吉田稔, 掛谷秀昭
- Organizer
  第5回日本ケミカルバイオロジー学会年会
- Place of Presentation
  神奈川
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] Modes of action of theonellamides, antifungal bicyclic peptides from a marine sponge2010
- Author(s)
  Shinichi Nishimura, et al.
- Organizer
  Pacifichem 2010
- Place of Presentation
  Hilton Hawaiian Village (Hawaii, U.S.A.)
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] ステロールを標的とするtheonellamideの作用機序解析2010
- Author(s)
  西村慎一, et al.
- Organizer
  第5回ケミカルバイオロジー学会年会
- Place of Presentation
  慶応義塾大学(神奈川県)
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] 海産抗真菌物質theonellamideの作用機序解明2010
- Author(s)
  西村慎一, 越智順子, 有田裕子, 松山晃久, 吉田稔, 掛谷秀昭.
- Organizer
  日本薬学会近畿支部会
- Place of Presentation
  大阪
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] Regulation of sterol localization revealed by chemical genetics using theonellamide2009
- Author(s)
  Shinichi Nishimura
- Organizer
  The 5th international fission yeast meeting
- Place of Presentation
  東京、代々木
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] Regulation of sterol localization revealed by chemical genetics using the onellamide.2009
- Author(s)
  Nishimura, S., Matsuyama, A., Yoshida,M., Matsunaga, S., Kakeya, H.
- Organizer
  The 5th International Fission Yeast Meeting.
- Place of Presentation
  Tokyo, Japan.
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] ステロールを標的とするtheonellamide類が誘導する分裂酵母の形態異常2009
- Author(s)
  西村慎一, 松山晃久, 松永茂樹, 掛谷秀昭, 吉田稔
- Organizer
  第42回酵母遺伝学フォーラム研究報告会
- Place of Presentation
  茨城
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] ステロールを標的とするtheonellamide類が誘導する分裂酵母の形態異常2009
- Author(s)
  西村慎一
- Organizer
  第42回酵母遺伝学フォーラム研究報告会
- Place of Presentation
  茨城、筑波
- Data Source
  KAKENHI-PROJECT-21710227
[Presentation] 分裂酵母のゲノムリソースを利用したケミカルゲノミクス2007
- Author(s)
  西村慎一
- Organizer
  ケミカルバイオロジー研究会第2回年会
- Place of Presentation
  京都大学
- Year and Date
  2007-05-09
- Data Source
  KAKENHI-PROJECT-18710194
[Presentation] 生体膜を標的とする天然物の作用機序解析を指向したLiDEL法の開発
- Author(s)
  森山彰博, 西村慎一, 掛谷秀昭
- Organizer
  日本ケミカルバイオロジー学会・第9回年会
- Place of Presentation
  大阪
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-25560415
[Presentation] Marine natural products targeting cell membrane.
- Author(s)
  Nishimura, S., Sugiyama, R., Matsumori, N., Kakeya, H.
- Organizer
  International Chemical Biology Society 2014
- Place of Presentation
  San Francisco
- Year and Date
  2014-11-17 – 2014-11-19
- Data Source
  KAKENHI-PUBLICLY-26102726
[Presentation] Marine natural products targeting cell membrane.
- Author(s)
  Nishimura, S., Sugiyama, R., Matsumori, N., Kakeya, H.
- Organizer
  3rd Annual Conference of the International Chemical Biology Society
- Place of Presentation
  San Francisco
- Year and Date
  2014-11-17 – 2014-11-19
- Data Source
  KAKENHI-PROJECT-25702048

1. HATTORI Akira (50300893)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. OISHI Shinya (80381739)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 吉田稔 (80191617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
4. FUJIWARA Hiroshi (30252456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. INOUE Hideshi (20184765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MARUYAMA Masato (00399445)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 掛谷秀昭 (00270596)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
8. 井本正哉 (60213253)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 伊藤昭博 (40391859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 有岡学 (20242159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. Kinoshita Masanao

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
12. YAMAGUCHI Yoshiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. KANOH Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 尾仲宏康

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
15. 浅水俊平

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
16. 石橋正己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 荒井緑

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 荒井孝義

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. 甲斐正広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 松森信明

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
21. 村田道雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 花島慎弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 長田裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
24. 小林俊秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 岡村均

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 小林大貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishimura Shinichi 西村 慎一

NISHIMURA Shinichi 西村 慎一

西村 慎一 ニシムラ シンイチ

Research Projects

Research Products

Co-Researchers

マルチターゲットを有する膜脂質の化学オミクス解析Principal Investigator

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セリン代謝の化学遺伝学的解析Principal Investigator

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Innovative chemical genetics on novel function of endogenous metabolites

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Chemical biology on siderophore-mediated inter-microbial interactions

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Identification of new natural products targeting cell membrane and analyses of their modes of action.Principal Investigator

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Chemical communications in microbial interactions and development of useful bioactive ligands

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Analysis of cell membrane environments targeted by marine natural productsPrincipal Investigator

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アミノ酸代謝を制御するハブ分子の多面性の理解に向けた天然物化学遺伝学Principal Investigator

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Development of chemical probes for linking small molecules and their receptors.Principal Investigator

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Chemical genetics for understanding structure and function of cell membranesPrincipal Investigator

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代謝と細胞形態のクロストークを解析する天然物リガンドの探索と作用機序解析Principal Investigator

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Mechanism of unanchored polyubiquitin chain production

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Biochemical and physiological studies on deubiquitinating enzymes based on an analysis of the enzymatic activity dynamics

Principal Investigator

Nishimura Shinichi 西村慎一

NISHIMURA Shinichi 西村慎一

西村慎一ニシムラシンイチ