Karasawa Hideaki 唐澤秀明

… Alternative Names

Hideaki Karasawa 唐澤秀明

KARASAWA Hideaki 唐澤秀明

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Researcher Number	30547401
Other IDs	https://orcid.org/0000-0003-0358-3398
Affiliation (Current)	2026: 東北大学, 大学病院, 講師
Affiliation (based on the past Project Information) *help	2024 – 2025: 東北大学, 大学病院, 講師 2018 – 2023: 東北大学, 大学病院, 助教 2013 – 2016: 東北大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 49020:Human pathology-related / Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 大腸癌 / 個別化医療 / Cripto-1 / 腸内細菌 / メチル化 / ERK阻害薬 / MAPK / オルガノイド / マイクロエクソン / 治療標的 / バイオマーカー / Ｃｒｉｐｔｏ－１ … More Except Principal Investigator … More 大腸癌 / オルガノイド / 癌関連線維芽細胞 / インドール化合物 / ミトコンドリア / GDF-15 / ミトコンドリア機能 / 酸化ストレス / 腫瘍免疫 / カルレティキュリン / 免疫原性細胞死 / 癌間質 / DR分類 / Wntシグナル / Wnt5a / Wnt2 / 産学連携 / 流体工学 / トランスレーショナルリサーチ / 低侵襲治療 / 産業連携 / 医工学 Less

Elucidation of the pathological mechanism of desmoplastic reaction characterization in colorectal cancer with a focus on the interaction between cancer cells and cancer-associated fibroblasts
- Principal Investigator
  
  村上圭吾
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Tohoku University
カルレティキュリンの細胞表面への表出に酸化ストレス抵抗性が与える役割
- Principal Investigator
  
  梶原大輝
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
腸内環境制御による高メチル化型大腸癌の新規予防・治療戦略の開発Principal Investigator
- Principal Investigator
  
  唐澤秀明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Development of new treatment for colorectal cancer through improvement of mitochondrial function using indole compounds
- Principal Investigator
  
  大沼忍
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Organoid Culture for Next Generation Personalized Medicine against Colorectal CancerPrincipal Investigator
- Principal Investigator
  
  Karasawa Hideaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Mechanisms of metastasis promoted by cancer associated fibroblast via Wnt signal pathway in colorectal cancer
- Principal Investigator
  
  MUSHA Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Identification of novel microexon involved in the regulation of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Hideaki Karasawa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Tohoku University
Development of a weak shock wave pulse jet scalpel that achieves both local control of infiltrating lesions and preservation of postoperative function
- Principal Investigator
  
  Nakagawa Atsuhiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tohoku University
The function and prognostic significance of Cripto-1 in colorectal cancerPrincipal Investigator
- Principal Investigator
  
  Hideaki Karasawa
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University
Establishment of Cripto-1 targeting therapy for colorectal cancerPrincipal Investigator
- Principal Investigator
  
  KARASAWA Hideaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Digestive surgery
- Research Institution
  Tohoku University

All 2026 2024 2022 2021 2019 2016 2015 2014

All Journal Article Presentation Book

[Book] Cancer Stem Cells, Chapter: The Role of Cripto‐1 in Cancer and Cancer Stem Cells,2014
- Author(s)
  Hideaki Karasawa, Nadia P Castro, Maria Cristina Rangel, David S Salomon
- Total Pages
  552
- Publisher
  John Wiley & Sons
- Data Source
  KAKENHI-PROJECT-25893013
[Journal Article] Wnt2 Expression in Cancer-Associated Fibroblasts Precedes Lymph Node Metastasis in Orthotopic Transplantation Mouse Model of Colorectal Cancer2026
- Author(s)
  Karasawa Hideaki、Murakami Keigo、Miura Koh、Sasaki Hiroyuki、Ono Tomoyuki、Kajiwara Taiki、Yamamura Akihiro、Kamei Takashi、Ohnuma Shinobu、Furukawa Toru、Unno Michiaki
- Journal Title
  
  Tohoku J. Exp. Med.
  
  Volume: 268 Issue: 3 Pages: 369-377
- DOI
  10.1620/tjem.2025.J039
- ISSN
  0040-8727, 1349-3329
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K10358, KAKENHI-PROJECT-21K16431, KAKENHI-PROJECT-24K11819
[Journal Article] Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis2024
- Author(s)
  Inomata Yushi、Kuroha Masatake、Shimoyama Yusuke、Naito Takeo、Moroi Rintaro、Shiga Hisashi、Kakuta Yoichi、Karasawa Hideaki、Onuma Shinobu、Kinouchi Yoshitaka、Masamune Atsushi
- Journal Title
  
  Cancer Medicine
  
  Volume: 13 Issue: 2
- DOI
  10.1002/cam4.6992
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08679
[Journal Article] Calreticulin exposure induced by anticancer drugs is associated with the p53 signaling pathway in colorectal cancer cells2024
- Author(s)
  Naito Satoru、Kajiwara Taiki、Karasawa Hideaki、Ono Tomoyuki、Saito Tatsushi、Funayama Ryo、Nakayama Keiko、Ohnuma Shinobu、Unno Michiaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 733 Pages: 150665-150665
- DOI
  10.1016/j.bbrc.2024.150665
- Data Source
  KAKENHI-PROJECT-24K11819
[Journal Article] Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer2021
- Author(s)
  Mochizuki Y*, Funayama R*, Shirota M, Kikukawa Y, Ohira M, Karasawa H, Kobayashi M, Ohnuma S, Unno M, Nakayama K. *Equal contribution.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 149 Issue: 10 Pages: 1787-1800
- DOI
  10.1002/ijc.33758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07560, KAKENHI-PROJECT-21K08679
[Journal Article] Wnt5a in cancer-associated fibroblasts promotes colorectal cancer progression2021
- Author(s)
  Hirashima Tomoaki、Karasawa Hideaki、Aizawa Takashi、Suzuki Takashi、Yamamura Akihiro、Suzuki Hideyuki、Kajiwara Taiki、Musha Hiroaki、Funayama Ryo、Shirota Matsuyuki、Ohnuma Shinobu、Nakayama Keiko、Unno Michiaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 568 Pages: 37-42
- DOI
  10.1016/j.bbrc.2021.06.062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-19K09188, KAKENHI-PROJECT-21K08679
[Journal Article] The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer2021
- Author(s)
  Tayama Hodaka、Karasawa Hideaki、Yamamura Akihiro、Okamura Yasunobu、Katsuoka Fumiki、Suzuki Hideyuki、Kajiwara Taiki、Kobayashi Minoru、Hatsuzawa Yuuri、Shiihara Masahiro、Bin Li、Gazi Md Yeashin、Sato Mizuki、Kumada Kazuki、Ito Shigehiro、Shimada Muneaki、Furukawa Toru、Kamei Takashi、Ohnuma Shinobu、Unno Michiaki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 560 Pages: 59-65
- DOI
  10.1016/j.bbrc.2021.04.130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02996, KAKENHI-PROJECT-21K08679
[Journal Article] Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer2019
- Author(s)
  Aizawa Takashi、Karasawa Hideaki、Funayama Ryo、Shirota Matsuyuki、Suzuki Takashi、Maeda Shimpei、Suzuki Hideyuki、Yamamura Akihiro、Naitoh Takeshi、Nakayama Keiko、Unno Michiaki
- Journal Title
  
  Cancer Medicine
  
  Volume: 8 Issue: 14 Pages: 6370-6382
- DOI
  10.1002/cam4.2523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-19K09188, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18K19281
[Journal Article] The expression and functional role of Cripto-1 in human colorectal cancer2016
- Author(s)
  Sato J, Karasawa H, Suzuki T et al.
- Journal Title
  
  Ann Oncol (suppl)
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19867
[Presentation] 高メチル化型大腸癌発癌への腸内環境の関与2024
- Author(s)
  唐澤秀明, 齋藤達, 初沢悠人, 小野智之, 小林実, 梶原大輝, 鈴木秀幸, 渡辺和宏, 石田孝宣, 亀井尚, 大沼忍, 海野倫明
- Organizer
  第124回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-24K11819
[Presentation] 大腸癌切除検体を用いたトランスレーショナル研究～癌関連線維芽細胞とオルガノイド～2022
- Author(s)
  唐澤秀明，相澤卓，平嶋倫亮，田山穂高，市川英孝，小林実，梶原大輝，山村明寛，神山篤史，渡辺和宏，森川孝則，石田孝宣，亀井尚，大沼忍，海野倫明
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08679
[Presentation] 癌関連繊維芽細胞はWntシグナル経路を介して大腸癌におけるリンパ行性転移に関与する2022
- Author(s)
  唐澤秀明，村上圭吾, 相澤卓, 平嶋倫亮, 三浦康, 佐々木宏之小野智之, 小林実, 梶原大輝, 亀井尚, 大沼忍, 海野倫明
- Organizer
  第60回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08679
[Presentation] 大腸癌同所移植モデルにおける癌関連線維芽細胞のWnt2発現はリンパ節転移と関連する2021
- Author(s)
  唐澤秀明，三浦康，佐々木宏之，小林実，梶原大輝，亀井尚，大沼忍，海野倫明
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-19K09188
[Presentation] 大腸癌におけるERK阻害薬感受性とMAPK経路遺伝子変異の関連性2021
- Author(s)
  田山穂高，唐澤秀明，山村明寛，梶原大輝，小林実，椎原正尋，島田宗昭，古川徹，亀井尚，大沼忍，海野倫明
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08679
[Presentation] Cripto-1 expression and its function for tumor progression in human colorectal cancer2016
- Author(s)
  Karasawa H, Sato J, Nakayama S, Maeda S, Ohnuma S, Motoi F, Naitoh T, Unno M
- Organizer
  10th AACR-JCS Joint Conference
- Place of Presentation
  Maui, Hawaii
- Year and Date
  2016-02-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19867
[Presentation] The expression and functional role of Cripto-1 in human colorectal cancer2016
- Author(s)
  Sato J, Karasawa H, Suzuki T et al.
- Organizer
  ESMO asia 2016
- Place of Presentation
  Singapore (Singapore)
- Year and Date
  2016-12-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19867
[Presentation] Cripto-1 as a potent prognostic factor for human colorectal cancer2016
- Author(s)
  佐藤純，唐澤秀明，鈴木　貴ら
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜 (神奈川)
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-15K19867
[Presentation] Cripto-1 expression and its prognostic value in human colorectal cancer patients2015
- Author(s)
  佐藤純，唐澤秀明, 中山瞬, 前田晋平, 大沼忍, 元井冬彦, 内藤剛, 海野倫明
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K19867

1. 大沼忍 (70451565)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. 内藤剛 (50291258)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山村明寛 (30814678)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 村上圭吾 (60742707)

# of Collaborated Projects: 2 results

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5. Nakagawa Atsuhiro (10447162)

# of Collaborated Projects: 1 results

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6. MUSHA Hiroaki (30724322)

# of Collaborated Projects: 1 results

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7. 中山啓子 (60294972)

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8. 舟山亮 (20452295)

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9. 冨永悌二 (00217548)

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11. 中西史 (00547408)

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12. 大沢伸一郎 (00813693)

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13. 齋藤竜太 (10400243)

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14. 山下慎一 (10622425)

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27. 梶原大輝 (60844438)

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28. 小野智之 (40973516)

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32. 佐藤岳哉 (10312696)

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33. 阿部高明 (80292209)

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35. 古川徹

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36. 海野倫明

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Karasawa Hideaki 唐澤 秀明

Hideaki Karasawa 唐澤 秀明

KARASAWA Hideaki 唐澤 秀明

Research Projects

Research Products

Co-Researchers

Elucidation of the pathological mechanism of desmoplastic reaction characterization in colorectal cancer with a focus on the interaction between cancer cells and cancer-associated fibroblasts

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

カルレティキュリンの細胞表面への表出に酸化ストレス抵抗性が与える役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

腸内環境制御による高メチル化型大腸癌の新規予防・治療戦略の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatment for colorectal cancer through improvement of mitochondrial function using indole compounds

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Organoid Culture for Next Generation Personalized Medicine against Colorectal CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of metastasis promoted by cancer associated fibroblast via Wnt signal pathway in colorectal cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of novel microexon involved in the regulation of colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a weak shock wave pulse jet scalpel that achieves both local control of infiltrating lesions and preservation of postoperative function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The function and prognostic significance of Cripto-1 in colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of Cripto-1 targeting therapy for colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Cancer Stem Cells, Chapter: The Role of Cripto‐1 in Cancer and Cancer Stem Cells,2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Wnt2 Expression in Cancer-Associated Fibroblasts Precedes Lymph Node Metastasis in Orthotopic Transplantation Mouse Model of Colorectal Cancer2026

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Dickkopf 1 is expressed in normal fibroblasts during early stages of colorectal tumorigenesis2024

Author(s)

Karasawa Hideaki 唐澤秀明

Hideaki Karasawa 唐澤秀明

KARASAWA Hideaki 唐澤秀明