KATO HISAKAZU 加藤久和

… Alternative Names

KATO Hisakazu 加藤久和

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Researcher Number	30589312
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 助教 2016 – 2021: 大阪大学, 医学系研究科, 助教 2017: 大阪大学, 大学院医学系研究科, 助教 2016: 大阪大学, 医学系研究科, 特任助教(常勤) 2015: 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤) … More 2013 – 2014: 大阪大学, 医学(系)研究科(研究院), 特任研究員 2012 – 2014: 大阪大学, 医学(系)研究科(研究院), 研究員 2011: 大阪大学, 大学院・医学系研究科, 特任研究員 2010 – 2011: 大阪大学, 医学系研究科, 特任研究員 Less
Review Section/Research Field	Principal Investigator Cardiovascular medicine / Basic Section 49010:Pathological biochemistry-related / Circulatory organs internal medicine Except Principal Investigator Basic Section 53020:Cardiology-related / Circulatory organs internal medicine / Basic Section 55020:Digestive surgery-related / General medical chemistry / Cardiovascular medicine
Keywords	Principal Investigator ミトコンドリア / タンパク質分解 / ATP / 分子心臓学 / 循環器・高血圧 / エネルギー代謝 / 虚血 / PET / ミトコンドリア病 / スクリーニング … More / 心不全 / 薬剤スクリーニング / 虚血性心疾患 / ユビキチン / ATP合成酵素 / 細胞遊走 / 炎症性サイトカイン / タンパク質脱リン酸化酵素 / タンパク質キナーゼ / 血管内皮細胞 / 生体分子 / 組織・細胞 … More Except Principal Investigator ATP合成酵素 / 心不全 / 臨床循環器 / 分子循環器病学 / 難治性心不全 / 細胞核クロマチン / エピゲノム / 細胞死 / 創薬 / 進行再発大腸癌 / 大腸癌 / p53 / BRAF V600E変異 / 分子標的医薬品 / ミオシンATP分解酵素 / エネルギー代謝 / 遺伝子治療 / ミトコンドリア病 / アロステリック酵素活性化剤 / 酸化的リン酸化酵素群 / 低酸素 / 心臓拡張機能 / 生活習慣病 / 微小血管障害 / G0s2 / 心臓拡張不全 / ATP / 微小循環障害 / ミトコンドリア / エネルギー需給バランス / 介在版 / メカノストレス / 介在板 / 微小管 / AMPK / 細胞・組織 / 循環器・高血圧 / 生体分子 / 組織・細胞 Less

Identification of therapeutic targets for heart failure and development of intervention methods related to the control mechanism of cardiac pump function
- Principal Investigator
  
  高島成二
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
ATP産生増強作用による新規ミトコンドリア機能改善薬の創製Principal Investigator
- Principal Investigator
  
  加藤久和
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka University
BRAF変異陽性大腸癌に対する新規治療薬の開発
- Principal Investigator
  
  瀬戸寛人
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Fundamental research for elucidation of the molecular structure mechanism of oxidative phosphorylation enzymes and development of drug discovery
- Principal Investigator
  
  Takashima Seiji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Osaka University
Fundamental Research for the Development of Novel Therapeutic Agents for Mitochondrial Diseases by Stabilizing Regulators of ATP ProductionPrincipal Investigator
- Principal Investigator
  
  Kato Hisakazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka University
Development of novel therapeutic strategy for ischemic heart diseases through targeting protein degradationPrincipal Investigator
- Principal Investigator
  
  Kato Hisakazu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Elucidation of the irreversible mechanism of severe heart failure using biological monitoring murine heart failure model
- Principal Investigator
  
  ASANO Yoshihiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
Unraveling the mechanism by which G0S2 regulates mitochondrial ATP production under ischemiaPrincipal Investigator
- Principal Investigator
  
  Kato Hisakazu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
A novel AMPK singaling at the intercalated disc in heart
- Principal Investigator
  
  SHINTANI YASUNORI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Osaka University
Analysis of a novel mitochondrial protein AMF in energy metabolismPrincipal Investigator
- Principal Investigator
  
  KATO Hisakazu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  Osaka University
A New Diagnostics Method for Refractory Heart Failure
- Principal Investigator
  
  ASANO YOSHIHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
The regulation of cytoskeletal dynamics in endothelial cells during acute inflammationPrincipal Investigator
- Principal Investigator
  
  KATO Hisakazu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University
Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease
- Principal Investigator
  
  TAKASHIMA Seiji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Osaka University

[Journal Article] Restoration of Cardiac Myosin Light Chain Kinase Ameliorates Systolic Dysfunction by Reducing Superrelaxed Myosin2023
- Author(s)
  Hitsumoto T, Tsukamoto O, Matsuoka K, Li J, Liu L, Kuramoto Y, Higo S, Ogawa S, Fujino N, Yoshida S, Kioka H, Kato H, Hakui H, Saito Y, Okamoto C, Inoue H, Hyejin J, Ueda K, Segawa T, Nishimura S, Asano Y, Asanuma H, Tani A, Imamura R, Komagawa S, Kanai T, Takamura M, Sakata Y, Kitakaze M, Haruta JI, Takashima S.
- Journal Title
  
  Circulation
  
  Volume: - Issue: 25 Pages: 1902-1918
- DOI
  10.1161/circulationaha.122.062885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-23KJ1480, KAKENHI-PROJECT-22K12801, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20H03927, KAKENHI-PROJECT-23K24327
[Journal Article] Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.2022
- Author(s)
  Nishida Y, Yanagisawa S, Morita R, Shigematsu H, Shinzawa-Itoh K, Yuki H, Ogasawara S,　et al
- Journal Title
  
  Nat Commun.
  
  Volume: 13 Issue: 1 Pages: 7591-7591
- DOI
  10.1038/s41467-022-34771-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06130, KAKENHI-PROJECT-22K09391, KAKENHI-PROJECT-21H02064, KAKENHI-PROJECT-20K03794, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-21K15443, KAKENHI-PROJECT-21K15776, KAKENHI-PLANNED-18H05425, KAKENHI-PLANNED-19H05761, KAKENHI-PLANNED-19H05784, KAKENHI-PUBLICLY-22H04760, KAKENHI-PUBLICLY-22H04800, KAKENHI-PROJECT-21H02914
[Journal Article] Gene Transfer of Skeletal Muscle-Type Myosin Light Chain Kinase via Adeno-Associated Virus 6 Improves Muscle Functions in an Amyotrophic Lateral Sclerosis Mouse Model2022
- Author(s)
  Oya Ryohei、Tsukamoto Osamu、Hitsumoto Tatsuro、Nakahara Naoya、Okamoto Chisato、Matsuoka Ken、Kato Hisakazu、Inohara Hidenori、Takashima Seiji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 3 Pages: 1747-1747
- DOI
  10.3390/ijms23031747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17180, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20K07338
[Journal Article] Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation2022
- Author(s)
  Hakui Hideyuki、Kioka Hidetaka、Miyashita Yohei、Nishimura Shunsuke、Matsuoka Ken、Kato Hisakazu、Tsukamoto Osamu、（3人省略）、Saito Shigeyoshi、Ohta Kunio、Asanuma Hiroshi、Fu Hai Ying、Shinomiya Haruki、Yamada Noriaki、Ohtani Tomohito、Sawa Yoshiki、Kitakaze Masafumi、Takashima Seiji、Sakata Yasushi、Asano Yoshihiro
- Journal Title
  
  Science Translational Medicine
  
  Volume: 14 Issue: 628
- DOI
  10.1126/scitranslmed.abf3274
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-21H02914, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-21K08027, KAKENHI-PROJECT-22K08155, KAKENHI-PROJECT-21K15776, KAKENHI-PROJECT-19H03652
[Journal Article] Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy2021
- Author(s)
  Shinomiya Haruki、Kato Hisakazu、・・・・・・・・Mashimo Tomoji、・・・・・・・・・・・・・・・・Sakata Yasushi、Asano Yoshihiro
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 11
- DOI
  10.1096/fj.202100800r
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03974, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-19H03652
[Journal Article] The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression2021
- Author(s)
  Miyashita Y, Tsukamoto O, Matsuoka K, Kamikubo K, Kuramoto Y, Fu HY, Tsubota T, Hasuike H, Takayama T, Ito H, Hitsumoto T, Okamoto C, Kioka H, Oya R, Shinomiya H, Hakui H, Shintani Y, Kato H, Kitakaze M, Sakata Y, Asano Y, Takashima S
- Journal Title
  
  The FASEB Journal
  
  Volume: 35 Issue: 4
- DOI
  10.1096/fj.202002111rr
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-20K17151, KAKENHI-PROJECT-19H03652
[Journal Article] In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance2020
- Author(s)
  Kioka Hidetaka、Kato Hisakazu、Fujita Takeshi、Asano Yoshihiro、Shintani Yasunori、Yamazaki Satoru、Tsukamoto Osamu、Imamura Hiromi、Kogo Mikihiko、Kitakaze Masafumi、Sakata Yasushi、Takashima Seiji
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 2 Pages: 2041-2054
- DOI
  10.1096/fj.201901686r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
[Journal Article] AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP‐1702020
- Author(s)
  Yashirogi Shohei、Nagao Takemasa、Nishida Yuya、Takahashi Yusuke、Qaqorh Tasneem、Yazawa Issei、Katayama Toru、Kioka Hidetaka、Matsui Tsubasa S、Saito Shigeyoshi、Masumura Yuki、Tsukamoto Osamu、Kato Hisakazu、Ueda Hiromichi、Yamaguchi Osamu、Yashiro Kenta、Yamazaki Satoru、Takashima Seiji、Shintani Yasunori
- Journal Title
  
  EMBO reports
  
  Volume: 22 Issue: 1
- DOI
  10.15252/embr.202050949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-21K15443
[Journal Article] Non-Radioactive In Vitro Cardiac Myosin Light Chain Kinase Assays2020
- Author(s)
  Kamikubo Kenta、Tsukamoto Osamu、Uyama-Saito Yuki、Oya Ryohei、Tsubota Tomoya、Fujino Noboru、Asano Yoshihiro、Kato Hisakazu、Matsuoka Ken、Takashima Seiji
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: 160 Issue: 160 Pages: 1-1
- DOI
  10.3791/61168
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07338, KAKENHI-PROJECT-18H04050, KAKENHI-PROJECT-19H03652
[Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.2019
- Author(s)
  Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, et al.
- Journal Title
  
  Circulation
  
  Volume: In press Issue: 18 Pages: 2157-2169
- DOI
  10.1161/circulationaha.118.036761
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08627, KAKENHI-PROJECT-17K08657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-17K09578, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-18K08100, KAKENHI-PROJECT-17F17418, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15KK0302, KAKENHI-PROJECT-17K07251, KAKENHI-PROJECT-18K08033, KAKENHI-PROJECT-19K08538, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H01560, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-17H04018, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-18H04074, KAKENHI-PROJECT-18H02803, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-19H03652
[Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2019
- Author(s)
  Nagao Takemasa、Shintani Yasunori、Hayashi Takaharu、Kioka Hidetaka、Kato Hisakazu、Nishida Yuya、Yamazaki Satoru、Tsukamoto Osamu、Yashirogi Shohei、Yazawa Issei、Asano Yoshihiro、Shinzawa‐Itoh Kyoko、Imamura Hiromi、Suzuki Takeo、Suzuki Tsutomu、Goto Yu‐ichi、Takashima Seiji
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 1 Pages: 1859-1871
- DOI
  10.1096/fj.201800389r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K22246, KAKENHI-PROJECT-17H03646, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-18H02094, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K09408, KAKENHI-PROJECT-18H05272, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
[Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 22019
- Author(s)
  Kamikubo Kenta、Kato Hisakazu、Kioka Hidetaka、Yamazaki Satoru、Tsukamoto Osamu、Nishida Yuya、Asano Yoshihiro、Imamura Hiromi、Kawahara Hiroyuki、Shintani Yasunori、Takashima Seiji
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 40 Pages: 14562-14573
- DOI
  10.1074/jbc.ra119.008544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08105, KAKENHI-PROJECT-19K08581, KAKENHI-PROJECT-19K09408, KAKENHI-PUBLICLY-19H05293, KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-17H03657, KAKENHI-PROJECT-17K09577, KAKENHI-PROJECT-19K22386, KAKENHI-PROJECT-19H03652, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-17K09578
[Journal Article] Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms2017
- Author(s)
  Kondo H, Maksimova N, Otomo T*,Kato H, Imai A, Asano Y, Kobayashi K, Nojima S, Nakaya A, Hamada Y, Irahara K, Gurinova E, Sukhomyasova A, Nogovicina A, Savvina M, Yoshimori T, Ozono K Sakai N*
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 26 Pages: 173-183
- DOI
  10.1093/hmg/ddw377
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25111002, KAKENHI-PROJECT-15H05673, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08423, KAKENHI-PROJECT-16K19404, KAKENHI-PROJECT-15K09139
[Journal Article] A Development of Nucleic Chromatin Measurements as a New Prognostic Marker for Severe Chronic Heart Failure.2016
- Author(s)
  Kanzaki M, Asano Y, Ishibashi-Ueda H, Oiki E, Nishida T, Asanuma H, Kato H, Oka T, Ohtani T, Tsukamoto O, Higo S, Kioka H, Matsuoka K, Sawa Y, Komuro I, Kitakaze M, Takashima S, Sakata Y.
- Journal Title
  
  PLoS One.
  
  Volume: 11 Issue: 2 Pages: e0148209-e0148209
- DOI
  10.1371/journal.pone.0148209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K09139
[Journal Article] Btg2 is a Negative Regulator of Cardiomyocyte Hypertrophy through a Decrease in Cytosolic RNA.2016
- Author(s)
  Masumura Y, Higo S, Asano Y, Kato H, Yan Y, Ishino S, Tsukamoto O, Kioka H, Hayashi T, Shintani Y, Yamazaki S, Minamino T, Kitakaze M, Komuro I, Takashima S, Sakata Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 6 Issue: 1 Pages: 28592-28592
- DOI
  10.1038/srep28592
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04820, KAKENHI-PROJECT-15H04821, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15K08271, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K09139, KAKENHI-PROJECT-16K09500, KAKENHI-PROJECT-16K09501
[Journal Article] Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.2015
- Author(s)
  Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
- Journal Title
  
  Nat Commun.
  
  Volume: 6 Issue: 1 Pages: 6137-6137
- DOI
  10.1038/ncomms7137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-25461119
[Journal Article] Higdla is a oositive regulaator of cytochrome c oxidase2015
- Author(s)
  T. Hayashi, Y. Asano, Y. Shintani, H. Aoyama, H. Kioka, O. Tsukamoto, M. Hikita, K. Shinzawa-Itoh, K. Takajuji, S. Higo, H. Kato, S. Yamazaki, K. Matsuoka, A. Nakano, H. Asanuma, M. Asakura, T. Minamino, Y. Goto, T. Ogura, M. Kitakaze, I. Komuro, Y. Sakata, T. Tsukihara, S. Yoshikawa, S. Takashima
- Journal Title
  
  Proc. Nat. Acad. Sci. U.S.A.
  
  Volume: 112 Issue: 5 Pages: 1553-1558
- DOI
  10.1073/pnas.1419767112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PUBLICLY-25109540, KAKENHI-PROJECT-25860599, KAKENHI-PUBLICLY-26104532, KAKENHI-PROJECT-26291033, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26670402, KAKENHI-PROJECT-26860558, KAKENHI-PROJECT-26860559, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-25461119
[Journal Article] An interaction between GLP-1 and adenosine contributes to cardioprotection of a dipeptidyl peptidase 4 inhibitor from myocardial ischemia/reperfusion injury.2015
- Author(s)
  Ihara M, Asanuma H, Yamazaki S, Kato H, Asano Y, Shinozaki Y, Mori H, Minamino T, Asakura M, Sugimachi M, Mochizuki N, Kitakaze M.
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: in press Issue: 10 Pages: 1287-1297
- DOI
  10.1152/ajpheart.00835.2014
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-15K09111, KAKENHI-PROJECT-15K19378, KAKENHI-PROJECT-15H04821
[Journal Article] Noninvasive and quantitative live imaging reveals a potential stress-responsive enhancer in the failing heart.2014
- Author(s)
  Matsuoka K, Asano Y, Higo S, Tsukamoto O, Yan Y, Yamazaki S, Matsuzaki T, Kioka H, Kato H, Uno Y, Asakura M, Asanuma H, Minamino T, Aburatani H, Kitakaze M, Komuro I, Takashima S.
- Journal Title
  
  FASEB J.
  
  Volume: 28(4) Issue: 4 Pages: 1870-9
- DOI
  10.1096/fj.13-245522
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24790757, KAKENHI-PUBLICLY-25118709, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26253049, KAKENHI-PROJECT-26461108, KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-26860559
[Journal Article] Evaluation of intra-mitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation2013
- Author(s)
  Kioka H, Kato H, Fujikawa M, Tsukamoto O, Suzuki T, Imamura H, Nakano A, Higo S, Yamazaki S, Matsuzaki T, Tkafuji K, Asanuma H, Asakura M, Minamino T, Shintani Y, Yoshida M, Noji H, Kitakaze M, Komuro I, Asano Y and Takashima S
- Journal Title
  
  PNAS
  
  Volume: 111 Issue: 1 Pages: 273-278
- DOI
  10.1073/pnas.1318547111
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23227006, KAKENHI-PROJECT-23591093, KAKENHI-PROJECT-24390203, KAKENHI-PROJECT-24570149, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24591097, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-24790757, KAKENHI-PROJECT-24790917, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25253047, KAKENHI-PROJECT-25461119, KAKENHI-PROJECT-25860599, KAKENHI-PROJECT-26461108
[Journal Article] Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer.2012
- Author(s)
  K. Nishikawa, T. Asai, H. Shigematsu, K. Shimizu, H. Kato, Y. Asano, S. Takashima, E. Mekada, N. Oku, T. Minamino
- Journal Title
  
  J. Control. Release
  
  Volume: 160 Issue: 2 Pages: 274-280
- DOI
  10.1016/j.jconrel.2011.10.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-22890104, KAKENHI-PROJECT-23240126, KAKENHI-PROJECT-23659416, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047
[Journal Article] Development of anti-HB-EGF immunoliposomes for the treatment of breast cancer2011
- Author(s)
  Nishikawa K, Asai T, Shigematsu H, Shimizu K, Kato H, Asano Y, Takashima S, Mekada E, Oku N, Minamino T
- Journal Title
  
  J Control Release
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890104
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1(HP1)2010
- Author(s)
  Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S
- Journal Title
  
  J Biol Chem
  
  Volume: 285 Pages: 31337-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890104
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromat in protein 1 (HP1).2010
- Author(s)
  肥後修一朗、加藤久和
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 285 Pages: 31337-31347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890104
[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010
- Author(s)
  中野敦、加藤久和
- Journal Title
  
  Nature Cell Biology
  
  Volume: 12 Pages: 583-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890104
[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.2010
- Author(s)
  Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, Seguchi O, Higo S, Shintani Y, Asanuma H, Asakura M, Minamino T, Kaibuchi K, Mochizuki N, Kitakaze M, Takashima S.
- Journal Title
  
  Nat Cell Biol. 12(6)
  
  Pages: 583-590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Isoform-specific intermolecular disulfide bond formation of heterochromatin protein 1 (HP1).2010
- Author(s)
  Higo S, Asano Y, Kato H, Yamazaki S, Nakano A, Tsukamoto O, Seguchi O, Asai M, Asakura M, Asanuma H, Sanada S, Minamino T, Komuro I, Kitakaze M, Takashima S.
- Journal Title
  
  The Journal of biological chemistry. 285(41)
  
  Pages: 31337-31347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation2010
- Author(s)
  Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, Seguchi O, Higo S, Shintani Y, Asanuma H, Asakura M, Minamino T, Kaibuchi K, Mochizuki N, Kitakaze M, Takashima S
- Journal Title
  
  Nat Cell Biol
  
  Volume: 12 Pages: 583-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890104
[Journal Article] Extracellular protein kinase CK2 is a novel associating protein of neuropilin-1.2009
- Author(s)
  Shintani Y, Takashima S, Kato H, Komamura K, Kitakaze M.
- Journal Title
  
  Biochem Biophys Res Commun. 385(4)
  
  Pages: 618-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Identification of p32 as a novel substrate for ATM in heart.2008
- Author(s)
  Kato H, Takashima S, Asano Y, Shintani Y, Yamazaki S, Seguchi O, Yamamoto H, Nakano A, Higo S, Ogai A, Minamino T, Kitakaze M, Hori M.
- Journal Title
  
  Biochem Biophys Res Commun. 366(4)
  
  Pages: 885-891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Identification of a novel substrate for TNFalpha-induced kinase NUAK2.2008
- Author(s)
  Yamamoto H, Takashima S, Shintani Y, Yamazaki S, Seguchi O, Nakano A, Higo S, Kato H, Liao Y, Asano Y, Minamino T, Matsumura Y, Takeda H, Kitakaze M.
- Journal Title
  
  Biochem Biophys Res Commun. 365(3)
  
  Pages: 541-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Journal Article] Atorvastatin slows the progression of cardiac remodeling in mice with pressure overload and inhibits epidermal growth factor receptor activation.2008
- Author(s)
  Liao Y, Zhao H, Ogai A, Kato H, Asakura M, Kim J, Asanuma H, Minamino T, Takashima S, Kitakaze M.
- Journal Title
  
  Hypertens Res. 31(2)
  
  Pages: 335-344
- NAID
  10024360118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390225
[Presentation] 新鮮臨床検体を用いた大腸癌新規標的分子の探索2022
- Author(s)
  在田麻美、加藤久和、高橋秀和、関戸悠紀、波多豪、荻野崇之、三吉範克、植村守、土岐祐一郎、江口英利、高島成二
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07338
[Presentation] ATP合成酵素活性化剤による虚血性心疾患治療法の開発2022
- Author(s)
  加藤　久和
- Organizer
  WISH＆SEEDsマッチング会　～大学SEEDsと企業WISHをモダリティと疾病領域の2軸で結ぶ初の取組み～
- Invited
- Data Source
  KAKENHI-PROJECT-20K07338
[Presentation] BRAF の活性化は心筋細胞の脱分化を誘導する2022
- Author(s)
  上田響子、加藤久和、高島成二
- Organizer
  第68回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-20K07338
[Presentation] BRAF V600EによるMAPKシグナルの活性化は心筋細胞の脱分化を誘導する2022
- Author(s)
  上田響子、加藤久和、高島成二
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07338
[Presentation] p53活性化による新規大腸癌治療法の開発2021
- Author(s)
  徳山信嗣,高橋秀和, 加藤久和, 藤野志季, 荻野崇之, 三吉範克, 植村守, 山本浩文, 水島恒和, 高島成二, 土岐祐一郎, 江口英利
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K07338
[Presentation] G0s2 is degraded by RNF126 through the interaction with BAG6-mediated molecular triage process.2019
- Author(s)
  Kenta Kamikubo, Hisakazu Kato, Seiji Takashima.
- Organizer
  Cold Spring Harbor Laboratory Meeting-Ubiquitin, Autophagy&Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09577
[Presentation] ミトコンドリアATP産生制御因子G0s2を特異的に分解する新規E3 ligaseの同定と機能解析2018
- Author(s)
  神窪謙太、加藤久和、高島成二
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-17K09577
[Presentation] G0S2を分子標的とした新規ATP合成酵素活性化剤の開発2018
- Author(s)
  加藤　久和
- Organizer
  創薬シーズ事業化コンペティション
- Invited
- Data Source
  KAKENHI-PROJECT-17K09577
[Presentation] ミトコンドリアATP産生制御因子G0s2を特異的に分解するE3複合体の同定と機能解析2018
- Author(s)
  神窪謙太、加藤久和、高島成二
- Organizer
  1.第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K09577
[Presentation] ミトコンドリアATP産生を制御因子G0s2の量的制御に関する機能解析2017
- Author(s)
  神窪謙太、加藤久和、高島成二
- Organizer
  第64回　日本生化学会　近畿支部例会
- Data Source
  KAKENHI-PROJECT-17K09577
[Presentation] ミトコンドリアATP産生制御因子G0s2タンパク質を特異的に分解する新規ユビキチンリガーゼの探索2017
- Author(s)
  神窪謙太、加藤久和、高島成二
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-17K09577
[Presentation] プロテアソーム依存的タンパク質分解を制御する化合物スクリーニング系の構築2015
- Author(s)
  加藤久和、木岡　秀隆、高島成二
- Organizer
  GE Life Sciences Day 2015
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-15K19378
[Presentation] Evaluation of Mitochondrial ATP Levels in Vivo Identifies G0/G1 Switch Gene 2 as a Therapeutic Target of Ischemic Heart Failure2014
- Author(s)
  Hisakazu KATO, Hidetaka KIOKA, Yoshihiro ASANO, Seiji TAKASHIMA
- Organizer
  第18回日本心不全学会学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-25860599
[Presentation] hypoxia-inducible protein MENT enhances mitochondrial ATP production by interacting with FoF1-ATP synthase2013
- Author(s)
  Hisakazu KATO, Hidetaka Kioka, Makoto Fujikawa, Toshiharu Suzuki, Hiromi Imamura, Masasuke Yoshida, Yoshihiro Asano, Seiji Takashima
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸　ポートアイランド
- Data Source
  KAKENHI-PROJECT-25860599

1. TSUKAMOTO Osamu (80589151)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. ASANO Yoshihiro (60527670)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. TAKASHIMA Seiji (90379272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. MINAMINO Tetsuo (30379234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. YAMAZAKI Satoru (70348796)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. HIGO Shuichiro (00604034)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. OGITA Hisakazu (50379236)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. SANADA Shoji (70593797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. SHINTANI YASUNORI (20712243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. MORISHIMA Keisuke (60359114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YALIKUN Yaxiaer (30735064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMAGUCHI Osamu (90467580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松岡研 (90826190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 木岡秀隆 (70642099)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 瀬戸寛人 (10966518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 植村守 (10528483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 高橋秀和 (10528508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. NAKANO Atsushi

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. YASHIROGI Shohei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. YAZAWA Issei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. ASAKURA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
22. MIN Kyung-Duk

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
23. ITO Shin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. NAKAHARA Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. IHARA Madoka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 真下知士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 北風政史

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
28. 浅沼博司

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
29. 浅井知浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 小倉尚志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 新沢伊藤恭子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 吉森保

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 野地博行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KATO HISAKAZU 加藤 久和

KATO Hisakazu 加藤 久和

Research Projects

Research Products

Co-Researchers

Identification of therapeutic targets for heart failure and development of intervention methods related to the control mechanism of cardiac pump function

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ATP産生増強作用による新規ミトコンドリア機能改善薬の創製Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

BRAF変異陽性大腸癌に対する新規治療薬の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental research for elucidation of the molecular structure mechanism of oxidative phosphorylation enzymes and development of drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fundamental Research for the Development of Novel Therapeutic Agents for Mitochondrial Diseases by Stabilizing Regulators of ATP ProductionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic strategy for ischemic heart diseases through targeting protein degradationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the irreversible mechanism of severe heart failure using biological monitoring murine heart failure model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Unraveling the mechanism by which G0S2 regulates mitochondrial ATP production under ischemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel AMPK singaling at the intercalated disc in heart

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of a novel mitochondrial protein AMF in energy metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A New Diagnostics Method for Refractory Heart Failure

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The regulation of cytoskeletal dynamics in endothelial cells during acute inflammationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease

Principal Investigator

Project Period (FY)

KATO HISAKAZU 加藤久和

KATO Hisakazu 加藤久和