Higuchi Takashi 樋口孝

… Alternative Names

Researcher Number	30595327
Other IDs
Affiliation (Current)	2021: 東京慈恵会医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2013 – 2021: 東京慈恵会医科大学, 医学部, 助教 2012: 東京慈恵会医科大学, 医学部, その他 2011 – 2012: 東京慈恵会医科大学, 医学部, ポストドクトラルフェロー
Review Section/Research Field	Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords	Principal Investigator 遺伝病 / ポンペ病 / 人工多能性幹細胞(iPS細胞) / 人工多能性幹細胞 / 酸性αグルコシダーゼ / ライソゾーム病 / iPS細胞 / アンダーソン・ファブリー病 / 末梢神経症状 / 痛み … More Except Principal Investigator ライソゾーム病 / 遺伝子治療 / 酵素補充療法 / 抗体 / 免疫寛容 / レンチウイルスベクター / ライソゾーム病蓄積症 / ファブリー病 / ポンぺ病 / 抗CD3抗体 / 経口投与 / ポンペ病 / 免疫寛容療法 / ムコ多糖症Ⅱ型 / 骨病変 / 病理 / 骨代謝 / Ｈｕｎｔｅｒ　ｓｙｎｄｒｏｍｅ / 骨芽細胞 / 骨質系 / イズロン酸サルファターゼ / レンチウイルス / 遺伝・先天異常 / 先天代謝異常症 / 先天代謝異常 / 遺伝・先天異常学 / 先天代謝異常学 / iPS細胞 / ＭＰＳ / クラッベ病 / 神経系スフェア / 治療補助用デバイス / 神経細胞デバイス / 神経系起源基細胞 / 遺伝子改変 / ムコ多糖症 / 治療用デバイス / ジンクフィンガー / デバイス / 自家移植 / 遺伝子編集 / iPS細胞を分化させて / GM1ガングリオシド―シス / 造血幹細胞 / アデノ随伴ウイルスベクター / ＧＭ１ガングリオシドーシス / GM1ガングリオシドーシス / ムコ多糖症II型 Less

BBB通過型GALC発現AAVベクターはクラッベ病マウスの寿命延長効果を持つかPrincipal InvestigatorOngoing
- Principal Investigator
  
  樋口孝
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
細胞送達能を高めた改変型酵素を用いるムコ多糖症II型の造血幹細胞遺伝子治療法開発Ongoing
- Principal Investigator
  
  嶋田洋太
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosisOngoing
- Principal Investigator
  
  大橋十也
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Jikei University School of Medicine
Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation
- Principal Investigator
  
  Ohashi Toya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Preparation of device for mucopolysaccharidosis treatment using iPS cells and gene modification system
- Principal Investigator
  
  Kobayashi Hiroshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Improvement of peripheral neuropathy by Adeno-associated virus vector expressing a-galactosidase A in murine Fabry modelPrincipal Investigator
- Principal Investigator
  
  HIGUCHI TAKASHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect
- Principal Investigator
  
  Ida Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases
- Principal Investigator
  
  OHASHI TOYA
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Generation of iPSCells from human fibroblast with Pompe Disease and Pathological Analysis of the iPS CellsPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine

All 2017 2016 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] ライソゾーム病-最新の病態,診断,治療の進歩2011
- Author(s)
  樋口孝、他
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791196
[Book] ライソゾーム病2011
- Author(s)
  樋口孝
- Total Pages
  283
- Publisher
  診断と治療社
- Data Source
  KAKENHI-PROJECT-23791196
[Journal Article] Morphological Features of iPS cells generated from Fabry disease Skin Fibroblasts using Sendai virus vector2013
- Author(s)
  Shiho Kawagoe, Takashi Higuchi,他8人
- Journal Title
  
  Molecular Genetics and Metabolism
  
  Volume: (印刷中)
- URL
  http://www.journals.elsevier.com/molecular-genetics-and-metabolism/
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791196
[Presentation] Improvement of peripheral neuropathy in murine Fabry model by intrathecal administration of serotype 9 Adeno-associated virus vector expressing α-galactosidase A2017
- Author(s)
  TAKASHI HIGUCHI, YOHTA SHIMADA, HIROSHI KOBAYASHI, TAKAHIRO FUKUDA, HIDETOSHI KABURAGI, MITSUHIRO ENOMOTO, FUSAO KATO, HIROYUKI IDA, TOYA OHASHI
- Organizer
  23rd JSGCT 2017
- Data Source
  KAKENHI-PROJECT-15K19637
[Presentation] Therapeutic strategy for Fabry disease peripheral neuropathy with rAAV vector2017
- Author(s)
  TAKASHI HIGUCHI, YOHTA SHIMADA, HIROMI HIRAKI, HIROSHI KOBAYASHI, TAKAHIRO FUKUDA, FUSAO KATO, TOYA OHASHI
- Organizer
  59th JSIMD 2017
- Data Source
  KAKENHI-PROJECT-15K19637
[Presentation] Gene Therapy and Gene Editing for Lysosomal Storage diseases2017
- Author(s)
  小林博司、飯塚佐代子、有賀賢典、福田隆浩、嶋田洋太、樋口孝、岩本武夫、Katherine Ponder, Mark Haskns, 大橋十也
- Organizer
  The 23rd Annual Meeting of Japan Society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-15K09601
[Presentation] MPS II型もdルマウス脳病変における、免疫寛容導入療法併用大量酵素補充療法の効果2017
- Author(s)
  横井健太郎、横井貴之、嶋田洋太、樋口孝、小林博司、大橋十也、井田博幸
- Organizer
  日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-15K09600
[Presentation] Treatment for Fabry peripheral neuropathy with Adeno-Associated Virus Vector in Murine Fabry Disease Model2016
- Author(s)
  T HIGUCHI, Y SHIMADA, H KOBAYASHI, T OHASHI
- Organizer
  Japan Society of Gene and Cell Therapy (JSGCT)
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-15K19637
[Presentation] Treatment for Anderson-Fabry disease peripheral neuropathy with adeno-associated virus vector encoded human α- galactosidase A gene in a murine model of Fabry disease2016
- Author(s)
  T Higuchi, Y Shimada, H Kobayashi, H Ida, T Ohashi
- Organizer
  Society for the Study of Inborn Errors of Metabolism (SSIEM)
- Place of Presentation
  Rome, Italy
- Year and Date
  2016-09-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19637
[Presentation] Pathological Features of Induced Pluripotent Stem Cells (iPSCs) Generated from Skin Fibroblasts of Various Lysosomal Storage Diseases2013
- Author(s)
  Takashi Higuchi,他10人
- Organizer
  12th International Congress of Inborn Errors of Metabolism(ICIEM2013)
- Place of Presentation
  バルセロナ・スペイン
- Data Source
  KAKENHI-PROJECT-23791196
[Presentation] Generation of iPS Cells from human fibroblast with Pompe Disease and Pathological Analysis of the iPS Cells2013
- Author(s)
  Takashi Higuchi,他10人
- Organizer
  The 3rd Asian Congress for Inherited Metabolic Diseases (ACIMD), The 55th Annual Meeting of The Japanese Society for Inherited Metabolic Diseases(JSIMD)
- Place of Presentation
  舞浜市・千葉県
- Data Source
  KAKENHI-PROJECT-23791196
[Presentation] ゴーシェ病及びポンペ病患者皮膚細胞由来iPS様細胞の樹立2012
- Author(s)
  樋口孝
- Organizer
  日本先天代謝異常学会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-23791196
[Presentation] ゴーシェ病及びポンペ病患者皮膚細胞由来iPS様細胞の樹立2012
- Author(s)
  樋口孝、他9人
- Organizer
  第54回日本先天代謝異常学会総会
- Place of Presentation
  岐阜市・岐阜県
- Data Source
  KAKENHI-PROJECT-23791196
[Presentation] センダイウイルスを用いたヒトファブリー病由来iPS様細胞の樹立2012
- Author(s)
  河越しほ、樋口孝、他2人
- Organizer
  第54回日本先天代謝異常学会総会
- Place of Presentation
  岐阜市・岐阜県
- Data Source
  KAKENHI-PROJECT-23791196
[Presentation] 免疫寛容導入による効果的ポンペ病酵素補充療法の開発
- Author(s)
  大橋十也　嶋田洋太　樋口孝　飯塚佐代子　井田博幸　衞藤義勝　小林博司
- Organizer
  第56回日本先天代謝異常学会
- Place of Presentation
  仙台
- Year and Date
  2014-11-13 – 2014-11-15
- Data Source
  KAKENHI-PROJECT-24591526

1. OHASHI TOYA (60160595)

# of Collaborated Projects: 7 results

# of Collaborated Products: 7 results
2. KOBAYASHI Hiroshi (90266619)

# of Collaborated Projects: 7 results

# of Collaborated Products: 7 results
3. SHIMADA Yohta (20560824)

# of Collaborated Projects: 6 results

# of Collaborated Products: 6 results
4. Ida Hiroyuki (90167255)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. MAEDA Kazuhiro (50548849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 衞藤義勝 (50056909)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 齋藤充 (50301528)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 横井健太郎 (20459655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 渡部文子 (00334277)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 福田隆浩 (60228913)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. WADA Miho

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 衛藤義勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Higuchi Takashi 樋口 孝

HIGUCHI Takashi 樋口 孝

Research Projects

Research Products

Co-Researchers

BBB通過型GALC発現AAVベクターはクラッベ病マウスの寿命延長効果を持つかPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞送達能を高めた改変型酵素を用いるムコ多糖症II型の造血幹細胞遺伝子治療法開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosisOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Preparation of device for mucopolysaccharidosis treatment using iPS cells and gene modification system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of peripheral neuropathy by Adeno-associated virus vector expressing a-galactosidase A in murine Fabry modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of iPSCells from human fibroblast with Pompe Disease and Pathological Analysis of the iPS CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] ライソゾーム病-最新の病態,診断,治療の進歩2011

Author(s)

Publisher

Data Source

[Book] ライソゾーム病2011

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Morphological Features of iPS cells generated from Fabry disease Skin Fibroblasts using Sendai virus vector2013

Author(s)

Journal Title

URL

Data Source

[Presentation] Improvement of peripheral neuropathy in murine Fabry model by intrathecal administration of serotype 9 Adeno-associated virus vector expressing α-galactosidase A2017

Author(s)

Organizer

Data Source

[Presentation] Therapeutic strategy for Fabry disease peripheral neuropathy with rAAV vector2017

Author(s)

Organizer

Higuchi Takashi 樋口孝

HIGUCHI Takashi 樋口孝