IDA Hiroyuki 井田博幸

… Alternative Names

Researcher Number	90167255
Other IDs
External Links
Affiliation *help	2014 – 2018 : 東京慈恵会医科大学, 医学部, 教授 2002 – 2004 : Jikei Univ, Dept. of Pediatrics asso prof, 医学部, 助教授 1999 – 2001 : 東京慈恵会医科大学, 医学部, 講師 1996 – 1999 : 東京慈恵会医科大学, 医学部・小児科, 講師 1996 : The Jikei University School of Medicine assi.prof., 小児科, 講師 … More
Review Section/Research Field	Principal Investigator Pediatrics / Pediatrics Except Principal Investigator Pediatrics / Pediatrics / Medical and hospital managemen
Keywords	Principal Investigator Gaucher disease / ゴーシェ病 / 遺伝子治療 / 酵素補充療法 / Neurolipidosis / 動物モデル / 遺伝子変異 / ゴ-シェ病 / 臨床症状 / 臨床表現型 … More Except Principal Investigator 遺伝子治療 / MLD / アデノウイルスベクター / ムコ多糖症 / サイコシン / beta-glucuronidase / Gaucher病 / レトロウイルスベクター / Gaucher disease / Sly病 / MPS VII / 異染性脳白質変性症 / Krabbe病 / Twitcherマウス / gene therapy / Sly disease / レトロウイルス / リソゾーム病 / 酵素補充療法 / 中枢神経 / 脳血液関門 / Krabbe's disease / retrovirus / ファブリー病 / 動物モデル / Gene Therapy / ムコ多糖症VII型 / 遺伝子解析 / アデノウイルス / Slyマウス / DNA診断 / 臨床表現型 / β-glucuronidase / ゴ-シェ病 / (1)krabbe病 / 医療の質 / 抗体作成 / オリゴデンドロサイト / retroviral vector / multiple sulfatase deficiency / プロティンキナーゼC活性 / Sly病(Sly disease) / CD71 / マルチプルサルファタ-ゼ欠損症 / エステル化障害 / Animal model / RT-PCR / グリア細胞 / α_2ーマクログロブリン / genetic disorder / deficient cholesterol esterification / スフィンゴシングルコサイコシン / matachromatic leukodystrophy(MLD) / Twitcher mouse / RT-PCR法 / Twitcher mice / スフィンゴシェリン / neural stem cell therapy / Conduritol-B-epoxedo (CBE) / Lacz遺伝子 / Leucodystrophy / リン酸化障害 / CDS mouse / グルコセレブロシダーゼ / Gene mutation / Ca代謝 / cerebrosideーβーgalactoside / スフィンゴリピド / Inborn errors of metabolism / 酵素補充法 / Niemann-Pick disease type C / アリルサルファターゼA・B / SSCP / 骨髄幹細胞(CD34+細胞) / クラッベ病マウス / glicosylsphingosine / レトロウィルスベクター / ニーマンピック病 / C-DNAのクローニング / mannnose terminal / GLD培養細胞 / neurophic factor / Genetic homogenity / 胎児肝細胞移植 / ヒトニーマンピック病タイプC / Neural progenitor / アルチプルサルファタ-ゼ欠損症 / 薬剤性有害事象 / 神経培養 / PCR / Cross hybridization / Niemann-Pick Disease TypeC / 中枢神経培養細胞 / β-galactosidase / アデノウィルスベクター / 神経幹細胞 / コレステロ-ルエステル / Adenovirus Vector / 遺伝子導入 / NemannーPick病 / Monoclonal antibody / ガラクトサミン / ゴーシェ病 / Nieman-Pick病typeC / Niemann-Pick mouse / 細胞内カルシウム濃度 / クラベ病 / SPMマウス / Gaucher Disease / fetus gene therapy / 中枢神経症状 / 脳障害 / E-64 / maternal blood / サザンブロット法 / Metachromatic leukodystrophy(MLD) / ライソゾ-ム酵素 / ArylsulfataseA / 出生前診断 / 遺伝学的類似性 / アデノ随伴ウイルス / 遺伝性脳白質変性症 / Retrovirus / Lysosomal disorder / アリルサルファターゼA.B,C-DNAのクローニング / Gaucher's disease / リポゾ-ム / 精製 / genotype / cerebrosideβ-galactosidase / CDNAクローニング / Niemann-Pick Disease / 細胞内プロセシング / ヘルペスウイルスベクター / Cytkine / Niemann-Pick病type C / MPSVII / (2)サイコシン / Fabry disease / Macrophage / ニーマンピック病マウス / PCR-SSCP法 / psychosine / ^ース / レクチン法 / リボゾ-ム / Pre-natal Gene therapy / 脳血管関門 / 遺伝型と臨床型 / 培養神経細胞 / 費用分析研究 / 母体血 / コレステロールエステル / metachromatic leukodystrophy / 遺伝子導入効率 / スフィンゴミエリン / Arylsulfatese A / 神経細胞培養 / PMD / adenovirus / マクロファージ / Sjogren-Larsson / オリゴデンドログリア細胞 / ASO / neuronal cell / αーマンノ-ス含有リポゾ-ム / アリルサルファターゼ / 遺伝子変異 / glucosylsphingosine / Psychosine / リソゾーム蓄積症 / prenatal diagnosis / リピドーシス / 胎児血球 / CD34+ cells / β-glucuronidase遺伝子 / リポゾーム / 骨髄細胞 / ライソゾ-ム病 / (4)培養オリゴデンドロサイト / 遺伝病 / アリルスルファターゼA遺伝子 / 胎児遺伝子治療 / 出生前治療 / 臨床疫学研究 / ヒト骨髄細胞 / アリルサルファターゼA / SPM mouse / MPS VII mice / Cholesterol esterification / 母体 / 先天代謝異常症 / lectin method / glucocerebroside / アリルサルファタ-ゼA / クラッベ病 / blood brain barrier / Gene Tharapy / 酵素抗体染色 / アミノ酸配列 / 脳変性疾患 / 胎児肝臓 / 胎児血 / Adenovirus / AAV / モノクローナル抗体 / コレステロ-ル / サイトカイン / 先天性ミエリン形成異常症 / コレステロールのエステル化障害 / 染色体異常症 / transduction / 酵素精製 / CD34+細胞 / ガラクトシ-ルーβーガラクトシダ-ゼ / Sly mice / Krabbe disease / krabbe病 / Arylsulfatase A / PCR-SSCP / 遺伝子異常 / 骨髄前駆細胞 / 遺伝性白質変性症 / (5)Twitcherマウス / 遺伝子変異解析 / SV-40 / CSDマウス / fetal blood / Human Oligodendroglioma(HOG)細胞 / liposome / サルファターゼ / 骨髄移植 / 薬剤関連エラー / (3)脱髄 / ニ-マンピック病 / Glucocerebrosidase / LTCIC(Long Term Culture Iniciating Cell) / モデルマウス / 小児 / マンノ-ス / 小児医療 / CMVpromotor / Nieman-Pick病type C / NOD-SCIDマウス / Conduritol-B-epoxide(CBE) / Retrovirus vector / HIV-Tat / RSV / 細胞内転送機構 / chromosomal disorders / 遺伝性ロイコヂストロフィー症 Less

小児入院患者における薬剤関連エラーによる健康被害の疫学と費用分析研究Ongoing
- Principal Investigator
  
  作間未織
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical and hospital managemen
- Research Institution
  Hyogo College of Medicine
Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic EffectPrincipal Investigator
- Principal Investigator
  
  Ida Hiroyuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
ゴーシェ病の中枢神経症状発現機序及び治療に関する研究Principal Investigator
- Principal Investigator
  
  井田博幸
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
脳血管関門を通過する酵素製剤の開発に関する研究
- Principal Investigator
  
  大橋十也
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Development of novel therapy and elucidation of pathophysiology for genetic leukodystrophy
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Gene therapy for neurogical abnormality using mouse model of lipidosisPrincipal Investigator
- Principal Investigator
  
  IDA H, 洲鎌盛一
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Molecular Pathogenesis of Brain Damage and Gene Therapy in Genetic Leukodystrophy
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University Shool of Medicine
Prenatal Diagnosis of Ingenited Metabolic Disorders Using Maternal Blood
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University Shool of Medicine
Gene therapy for central nervous involvement of Gaucher diseasePrincipal Investigator
- Principal Investigator
  
  IDA Hiroyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene Therapy for Sly disease using AAV vector.
- Principal Investigator
  
  OHASHI Touya
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Treatment for congenital metabolic disorder with brain dysfunction.
- Principal Investigator
  
  TOKORO Toshiharu
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene therapy for brain damage using animal models with lipidoses
- Principal Investigator
  
  SUGAMA Seiichi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene therapy for CNS involvement of Lysosomal storage disease using various viral vector
- Principal Investigator
  
  ITO Fumiyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Studies of inherited neurodegenerative disease ; mutation analysis and gene therapy
- Principal Investigator
  
  MAEKAWA K.
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene therapy for Sly disease
- Principal Investigator
  
  OHASHI T.
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene therapy for neuronopathic Gaucher diseasePrincipal Investigator
- Principal Investigator
  
  IDA H.
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
The cause of neuropathochemistry of inherited Neurodegeneration
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療
- Principal Investigator
  
  衛藤義勝
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Gene Therapy toward to nuerodegenerative disorders using fetal hematopoietic stem cells transplantationPrincipal Investigator
- Principal Investigator
  
  IDA Hiroyuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene Therapy for Lysosomal Strage Disease
- Principal Investigator
  
  OHASHI Touya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療
- Principal Investigator
  
  衛藤義勝
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine
Molecular Analysis and Gene Therapy in Inherited dysmyelinating disorder
- Principal Investigator
  
  MAEKAWA Kihei
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine
Gene therapy for inherited neurodegenerative disease using fetal bone marrows stem cell transplantation.
- Principal Investigator
  
  TOKORO Toshiharu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei Univ.School of Medicine
Genetic analysis of Niemann-Pick model mouse.
- Principal Investigator
  
  TOKORO Toshoharu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei Univ.School of Medicine
リピド-シスマウス神経細胞に於けるガングリオシド代謝とその機能異常の解明
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Jikei University School of Medicine
Pathogenesis of Multiple Sulfatase Deficiency
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Jikei University School of Medicine
Modified enzyme which target to neuronal cells to cross blood brain barrier
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Tokyo Jikei University School of Medicine
The Pathogenesis of Demyelination in Krabbe's disease and it's therapy
- Principal Investigator
  
  TOKORO Toshiharu
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The Jikei University School of Medicine, Department of Pediatrics
Molecular and biochemical analysis of inherited degernerative brain disorder
- Principal Investigator
  
  ETO Yoshikatsu
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Department of Pediatrics, Tokyo Jikei University School of Medicine
c DNA cloning for human Arylsulfatase A
- Principal Investigator
  
  ITO Fumiyuki
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Jikei University School of Medicine

All 2017 2016 2015 2004

All Journal Article Presentation Book

[Book] ファブリー病について,ファブリー病2004
- Author(s)
  衛藤義勝, 井田博幸
- Total Pages
  7
- Publisher
  ブレーン出版(株)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370252
[Book] ファブリー病について,ファブリー病2004
- Author(s)
  衛藤義勝, 井田博幸
- Total Pages
  7
- Publisher
  ブレーン出版(株)
- Data Source
  KAKENHI-PROJECT-14370252
[Journal Article] N-octyl-β-valienamine up-regulates activity of F213I mutantβ-glucosidase in cultured cells ; a potential chemical chaperone therapy for Gaucher disease2004
- Author(s)
  Lin H, Ida H, et al.
- Journal Title
  
  Biochim Biophys Acta 1689
  
  Pages : 219-228
- Data Source
  KAKENHI-PROJECT-16591057
[Journal Article] リピドーシススクリーニング2004
- Author(s)
  井田博幸
- Journal Title
  
  小児科 45
  
  Pages : 2034-2040
- Data Source
  KAKENHI-PROJECT-16591057
[Journal Article] 酵素補充療法2004
- Author(s)
  井田博幸
- Journal Title
  
  小児科診療 67
  
  Pages : 533-537
- Data Source
  KAKENHI-PROJECT-16591057
[Presentation] ムコ多糖症モデルマウスの骨病変の分子・病理学的解析2017
- Author(s)
  和田美穂、小林博司、斎藤充、井田博幸　など
- Organizer
  第121回　日本小児科学会
- Place of Presentation
  東京
- Year and Date
  2017-04-14
- Data Source
  KAKENHI-PROJECT-26461533
[Presentation] ムコ多糖症モデルマウスの骨病変の病理・分子生物学的解析2016
- Author(s)
  和田美穂、小林博司、斎藤充、井田博幸　など
- Organizer
  第５８回　日本先天代謝異常学会
- Place of Presentation
  東京
- Year and Date
  2016-10-27
- Data Source
  KAKENHI-PROJECT-26461533
[Presentation] 小児入院患者における薬剤関連エラーの疫学　第2報：the JADE Study．2015
- Author(s)
  作間未織，井田博幸，森本剛．
- Organizer
  第118回日本小児科学会学術集会
- Place of Presentation
  大阪国際会議場（大阪府・大阪市）
- Year and Date
  2015-04-19
- Data Source
  KAKENHI-PROJECT-15K08862
[Presentation] Factors associated with medication errors in pediatric inpatients in Japan: the JADE study.2015
- Author(s)
  Sakuma M, Ida H, Morimoto T.
- Organizer
  Pediatric Academic Societies Annual Meeting
- Place of Presentation
  San Diego, USA.
- Year and Date
  2015-04-25
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08862

1. ETO Yoshikatsu (50056909)

# of Collaborated Projects : 24results

# of Collaborated Products : 2results
2. OHASHI T (60160595)

# of Collaborated Projects : 23results

# of Collaborated Products : 0results
3. HASEGAWA Yoriyasu (60256435)

# of Collaborated Projects : 11results

# of Collaborated Products : 0results
4. TOKORO Toshiharu (40112841)

# of Collaborated Projects : 9results

# of Collaborated Products : 0results
5. ETO Yoshikatsu (10057010)

# of Collaborated Projects : 7results

# of Collaborated Products : 0results
6. TSUDA Takashi (50188554)

# of Collaborated Projects : 7results

# of Collaborated Products : 0results
7. OHNO Noriya (60147288)

# of Collaborated Projects : 5results

# of Collaborated Products : 0results
8. KOBAYASHI H. (90266619)

# of Collaborated Projects : 4results

# of Collaborated Products : 2results
9. SUGAMA Seiichi (10154452)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
10. UMEZAWA Fusayo (50185063)

# of Collaborated Projects : 3results

# of Collaborated Products : 0results
11. SASAKI Nobuhiko (50170684)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
12. MAEKAWA Kihei (80056613)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
13. MATSUSHIMA Hiroshi (70190460)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
14. KAWAME H. (60246395)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
15. TOYODA Shigeru (90110931)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
16. 岩澤京子 (10301524)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
17. TAHARA Takahiro (80159029)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
18. 小林正久 (20312019)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
19. MAEDA Kazuhiro (50548849)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
20. KUSANO Kaoru (80205070)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
21. KUROSAWA Kenji (20277031)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
22. TANAKA T (50110929)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
23. OKAMOTO Aikou (20204026)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
24. MIYATA Ichiro (10200180)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
25. SUZUKI Hideaki (20206519)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
26. KANAMOTO Yurie (80130160)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
27. TADA Yuki (10179707)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
28. SEKIGUCHI Shigeru (90119818)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
29. 嶋田洋太 (20560824)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
30. 樋口孝 (30595327)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
31. 齋藤充 (50301528)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
32. 五味渕一三 (50205621)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
33. 伊藤建 (50276995)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
34. 作間未織 (60349587)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
35. 森本剛 (30378640)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
36. WADA Miho

# of Collaborated Projects : 1results

# of Collaborated Products : 2results

IDA Hiroyuki 井田 博幸

井田 博之 イダ ヒロユキ

Research Projects

Research Products

Co-Researchers

小児入院患者における薬剤関連エラーによる健康被害の疫学と費用分析研究Ongoing

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Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic EffectPrincipal Investigator

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ゴーシェ病の中枢神経症状発現機序及び治療に関する研究Principal Investigator

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Gene therapy for neurogical abnormality using mouse model of lipidosisPrincipal Investigator

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Gene therapy for central nervous involvement of Gaucher diseasePrincipal Investigator

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IDA Hiroyuki 井田博幸

井田博之イダヒロユキ