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Ohashi Toya  大橋 十也

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… Alternative Names

OHASHI TOYA  大橋 十也

OHASHI T.  大橋 十也

OHASHI Toya  大橋 十也

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Researcher Number 60160595
Other IDs
External Links
Affiliation (Current) 2022: 東京慈恵会医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2012 – 2020: 東京慈恵会医科大学, 医学部, 教授
2001 – 2004: Jikei Univ. Sch. Med., Gene Therapy, Assoc. Professor, DNA医学研究所, 助教授
2001 – 2004: Jikei Univ.,Dept. of Pedatrics, asso prof., 医学部, 助教授
2003: Jikei University School of Medicine, Associate Professor, 医学部, 助教授
2000: 東京慈恵会医科大学, DNA医学研究所, 講師 … More
1999 – 2000: 東京慈恵会医科大学, 医学部, 講師
1997 – 1999: Jikei University School of Medicine assi prof., 医学部・小児科, 講師
1998: 東京慈恵会医科大学, 小児科学講座, 講師
1997: 東京慈恵会医科大学, 医学部・小児科学講座, 講師
1996: 東京慈恵会医科大学, 医学部小児科, 講師
1996: The Jikei University School of Medicine assi.prof., 小児科, 講師
1995: 東京慈恵会医科大学, 医学部・小児科学, 助手
1995: 東京慈恵会医科大学, 医学部・微生物学第一, 助手
1995: 東京慈恵会医科大学, 小児科学, 助手
1992 – 1995: 東京慈恵会医科大学, 医学部, 助手
1993: 東京慈恵会医科大学, 医学部・小児科, 助手
1993: assistant, 小児科, 助手
1988: THE JIKEI UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PEDIATRICS
1988: 東京慈恵会医科大学, 小児科, 助手
1986 – 1987: 東京慈恵会医科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related
Except Principal Investigator
Pediatrics / Pediatrics / Neurology / Digestive surgery / Basic Section 52050:Embryonic medicine and pediatrics-related
Keywords
Principal Investigator
遺伝子治療 / ムコ多糖症 / Sly病 / Sly disease / beta-glucuronidase / ファブリー病 / 酵素補充療法 / 抗体 / 免疫寛容 / ライソゾーム病 … More / β-glucuronidase / retrovirus / MPS VII / HIV-Tat / 脳血管関門 / ライソゾーム病蓄積症 / ポンぺ病 / 抗CD3抗体 / 経口投与 / ポンペ病 / 免疫寛容療法 / レトロウイルス / アデノウイルス / 骨髄細胞 / 骨髄幹細胞(CD34+細胞) / NOD-SCIDマウス / LTCIC(Long Term Culture Iniciating Cell) / ムコ多糖症VII型 / ヒト骨髄細胞 / β-glucuronidase遺伝子 / CD34+細胞 / サザンブロット法 / 骨髄前駆細胞 / モデルマウス / adenovirus / CD34+ cells / transduction / マクロファージ / レトロウイルスベクター / Slyマウス / 遺伝子導入 / Sly病(Sly disease) / Macrophage / gene therapy / アデノ随伴ウイルス / MPSVII / Gene Therapy / AAV / 遺伝・先天異常 / 先天代謝異常症 / 先天代謝異常 / 遺伝・先天異常学 / 先天代謝異常学 / GM1ガングリオシド―シス / 造血幹細胞 / レンチウイルスベクター / アデノ随伴ウイルスベクター / GM1ガングリオシドーシス / GM1ガングリオシドーシス … More
Except Principal Investigator
遺伝子治療 / アデノウイルスベクター / Gaucher disease / ゴーシェ病 / gene therapy / MLD / 異染性脳白質変性症 / Gaucher病 / 遺伝子変異 / レトロウイルスベクター / ゴ-シェ病 / 動物モデル / Twitcherマウス / アデノウイルス / 臨床表現型 / 酵素補充療法 / Adenovirus / Krabbe病 / レトロウイルス / リピドーシス / 遺伝子解析 / genotype / 骨髄移植 / Neurolipidosis / リソゾーム病 / 中枢神経 / 中枢神経症状 / Gene Tharapy / 神経栄養因子 / 運動ニューロン / Avulsion / Facial nerve / Motoneuron / SOD1 / オリゴデンドロサイト / サルファターゼ / クラッベ病マウス / ニーマンピック病マウス / ヘルペスウイルスベクター / SV-40 / CMVpromotor / RSV / 肝臓 / 投与条件 / ADENO VIRUS / 外科 / ケミカルシャペロン / 神経症状 / ムコ多糖症Ⅱ型 / 骨病変 / 病理 / レンチウイルスベクター / 骨代謝 / Hunter syndrome / 骨芽細胞 / 骨質系 / イズロン酸サルファターゼ / レンチウイルス / Nerve Growth Factor / 異染性白質変性症 / クラベ病 / 脱髄 / 呼吸鎖リン酸化反応 / ミエリン形成異常症 / 制限酵素 / PCR法 / スプライスアクセプターサイト / Metachromatic / Krabbe's disease / demyelination / ヒトニーマンピック病タイプC / 胎児遺伝子治療 / コレステロールのエステル化障害 / レトロウィルスベクター / Lacz遺伝子 / 胎児肝臓 / アデノウィルスベクター / 脳血液関門 / Ca代謝 / コレステロールエステル / Niemann-Pick disease type C / fetus gene therapy / deficient cholesterol esterification / retroviral vector / 先天性ミエリン形成異常症 / matachromatic leukodystrophy(MLD) / RT-PCR法 / 遺伝子変異解析 / ArylsulfataseA / PCR-SSCP法 / PMD / PCR / ASO / SSCP / アリルスルファターゼA遺伝子 / 遺伝型と臨床型 / Gaucher Disease / RT-PCR / Arylsulfatase A / PCR-SSCP / 脳変性疾患 / 脳血液関門破壊 / 神経型ゴ-シェ病 / SSCP法 / 遺伝子変異分布 / ニーマンピック病 / 胎児造血幹細胞 / Phenotype / Genotype / transplantation / common mutation / L444P / グルコセレブロシダーゼ / Metachromatic leukodystrophy(MLD) / サイコシン / 遺伝性ロイコヂストロフィー症 / glicosylsphingosine / スフィンゴリピド / プロティンキナーゼC活性 / glucosylsphingosine / Human Oligodendroglioma(HOG)細胞 / Conduritol-B-epoxide(CBE) / 細胞内カルシウム濃度 / glucocerebroside / Conduritol-B-epoxedo (CBE) / 先天代謝異常症 / 遺伝子導入効率 / Inborn errors of metabolism / Retrovirus / Gene mutation / Animal model / 臨床症状 / モデルマウス / リソゾーム蓄積症 / ムコ多糖症VII型 / beta-glucuronidase / MPS VII mice / metachromatic leukodystrophy / 神経幹細胞 / Slyマウス / 遺伝子異常 / Sjogren-Larsson / neural stem cell therapy / Twitcher mice / Sly mice / 母体血 / 胎児血球 / 出生前診断 / レクチン法 / 染色体異常症 / 遺伝病 / ファブリー病 / 母体 / 胎児血 / CD71 / maternal blood / fetal blood / prenatal diagnosis / lectin method / chromosomal disorders / genetic disorder / Fabry disease / 遺伝子異変 / enzyme replacement therapy / phenotype / Nieman-Pick病type C / β-galactosidase / サイトカイン / Niemann-Pick病type C / Nieman-Pick病typeC / Neural progenitor / Niemann-Pick Disease TypeC / Adenovirus Vector / Cytkine / ミクログリア / Twitcher マウス / mutation / lysosomal disorder / MPS VII / krabbe病 / neurophic factor / 脳由来神経栄養因子(BDNF) / 毛様体神経栄養因子(CNTF) / TGFβ / グリア細胞株由来神経栄養因子(GDNF) / アデノウイルスベクター(3) / カルジオトロフィン-1 / Gene therapy / GDNF / BDNF / TGFβ2 / 神経細胞 / 胎児治療 / lipidosis / mouse model / CNS involvement / 遺伝性脳白質変性症 / 出生前治療 / クラッベ病 / 遺伝性白質変性症 / ムコ多糖症 / Gene Therapy / Leucodystrophy / Pre-natal Gene therapy / Krabbe disease / Retrovirus vector / 筋萎縮性側索硬化症 / シュワン細胞 / 顔面神経 / 運動神経損傷 / Adenovirus vector / Neurotrophic factor / ALS / Schwann cell / 異数染色体 / 染色体不安定性 / ウィルムス腫瘍 / チェックポイント / セントロメア / 有糸分裂 / 紡錘糸チェックポイント / aneuploidy / chromosome instability / Wilms'tumor / checkpoint / centromere / mitosis / アリルサルファターゼA / モノクローナル抗体 / CDNAクローニング / 酵素精製 / 抗体作成 / アリルサルファターゼA・B / 精製 / アミノ酸配列 / C-DNAのクローニング / アリルサルファターゼA.B,C-DNAのクローニング / DNA診断 / 細胞内プロセシング / Arylsulfatese A / Monoclonal antibody / ムコ多糖症II型 / ライソゾーム病 Less
  • Research Projects

    (33 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (38 People)
  •  細胞送達能を高めた改変型酵素を用いるムコ多糖症II型の造血幹細胞遺伝子治療法開発

    • Principal Investigator
      嶋田 洋太
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosisPrincipal Investigator

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Jikei University School of Medicine
  •  Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulationPrincipal Investigator

    • Principal Investigator
      Ohashi Toya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect

    • Principal Investigator
      Ida Hiroyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseasesPrincipal Investigator

    • Principal Investigator
      OHASHI TOYA
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  ゴーシェ病の中枢神経症状発現機序及び治療に関する研究

    • Principal Investigator
      井田 博幸
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  脳血管関門を通過する酵素製剤の開発に関する研究Principal Investigator

    • Principal Investigator
      大橋 十也
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Development of novel therapy and elucidation of pathophysiology for genetic leukodystrophy

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Neuropathological and therapeutic studies on adult motoneuron degeneration using rat peripheral nerve avulsion models

    • Principal Investigator
      WATABE Kazuhiko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Cloning of a novel tumor suppressor gene in Wilms' tumor associated with chromosome instability

    • Principal Investigator
      SUZUKI Hideaki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      JIKEI UNIVERSITY SCHOOL OF MEDICINE
  •  Gene therapy for neurogical abnormality using mouse model of lipidosis

    • Principal Investigator
      IDA H, 洲鎌 盛一
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Adenoviral gene transfer of neurotrophic factors to injured adult motoneurons

    • Principal Investigator
      WATABE Kazuhiko
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      TOKYO METROPOLITAN ORGANIZATION OF MEDICAL RESEARCH
  •  Molecular Pathogenesis of Brain Damage and Gene Therapy in Genetic Leukodystrophy

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University Shool of Medicine
  •  Prenatal Diagnosis of Ingenited Metabolic Disorders Using Maternal Blood

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University Shool of Medicine
  •  Gene therapy for central nervous involvement of Gaucher disease

    • Principal Investigator
      IDA Hiroyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene Therapy for Sly disease using AAV vector.Principal Investigator

    • Principal Investigator
      OHASHI Touya
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Treatment for congenital metabolic disorder with brain dysfunction.

    • Principal Investigator
      TOKORO Toshiharu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for Krabbe disease with microglial cells derived from brain

    • Principal Investigator
      GOMIBUCHI Ichizou
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for brain damage using animal models with lipidoses

    • Principal Investigator
      SUGAMA Seiichi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for CNS involvement of Lysosomal storage disease using various viral vector

    • Principal Investigator
      ITO Fumiyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  ADENOVIRAL VECTORを 使用した肝臓に対する遺伝子治療における投与条件の基礎的検討

    • Principal Investigator
      岡本 友好
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      Jikei University School of Medicine
  •  Studies of inherited neurodegenerative disease ; mutation analysis and gene therapy

    • Principal Investigator
      MAEKAWA K.
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for Sly diseasePrincipal Investigator

    • Principal Investigator
      OHASHI T.
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for neuronopathic Gaucher disease

    • Principal Investigator
      IDA H.
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  The cause of neuropathochemistry of inherited Neurodegeneration

    • Principal Investigator
      ETO Yoshikatsu
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療

    • Principal Investigator
      衛藤 義勝
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Gene Therapy toward to nuerodegenerative disorders using fetal hematopoietic stem cells transplantation

    • Principal Investigator
      IDA Hiroyuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene Therapy for Lysosomal Strage DiseasePrincipal Investigator

    • Principal Investigator
      OHASHI Touya
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  リピドーシス動物モデルを用いての中枢神経障害の遺伝子治療

    • Principal Investigator
      ETO Y.
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine
  •  Molecular Analysis and Gene Therapy in Inherited dysmyelinating disorder

    • Principal Investigator
      MAEKAWA Kihei
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  Gene therapy for inherited neurodegenerative disease using fetal bone marrows stem cell transplantation.

    • Principal Investigator
      TOKORO Toshiharu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei Univ.School of Medicine
  •  Studies of genetic analysis and gene therapy for myelin-associated disorders.

    • Principal Investigator
      MAEKAWA Kihei
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      The Jikei University School of Medicine
  •  c DNA cloning for human Arylsulfatase A

    • Principal Investigator
      ITO Fumiyuki
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Jikei University School of Medicine

All 2017 2005 2004 2003 2002 Other

All Journal Article Presentation Book

  • [Book] ファブリー病の治療、酵素補充療法,ファブリー病-基礎から臨床までの最近の知見-2004

    • Author(s)
      大橋十也
    • Total Pages
      10
    • Publisher
      ブレーン出版(株)
    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Anti-BlyS antibody reduces the immune reaction against enzyme and enhances the efficacy of enzyme replacement therapy in Fabry disease model mice.2017

    • Author(s)
      Sato Y, Ida H, Ohashi T
    • Journal Title

      Clin Immunol.

      Volume: 178 Pages: 56-63

    • DOI

      10.1016/j.clim.2017.01.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09600
  • [Journal Article] GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo.2005

    • Author(s)
      Meng XL, Shen JS, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      Mol Genet Metab. (in press)

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.2005

    • Author(s)
      Shen JS, Meng XL, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo.2005

    • Author(s)
      Meng XL, Shen JS, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      Mol Genet Metab. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.2005

    • Author(s)
      Shen JS, Meng XL, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] GALC transduction leads to morphological improvement of the twitcher oligodendrocytes in vivo.2005

    • Author(s)
      Meng X-L, Shen J-S, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      Mol Gene Metab 84

      Pages: 332-343

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] 最新の遺伝子治療診断と治療 Gaucher病の遺伝子変異2005

    • Author(s)
      大橋十也
    • Journal Title

      日本臨床 63(3)

      Pages: 498-500

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.2005

    • Author(s)
      Shen JS, Meng XL, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med (in press)

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease.2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med. 6(11)

      Pages: 1206-1215

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, Mori T, Umezawa A, Ohashi T, Eto Y
    • Journal Title

      Gene Ther 11(19)

      Pages: 1475-1481

    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, Mori T, Umezawa A, Ohashi T, Eto Y
    • Journal Title

      Gene Ther 11(19)

      Pages: 1475-1481

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Treatment of lysosomal storage disorders : Cell therapy and gene therapy.2004

    • Author(s)
      Eto Y, Shen JS, Meng XL, Ohashi T.
    • Journal Title

      J Inherit Metab Dis. 27(3)

      Pages: 411-415

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease.2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med 6(11)

      Pages: 1206-1215

    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease.2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med 6(11)

      Pages: 1206-1215

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Treatment of lysosomal storage disorders : Cell therapy and gene therapy.2004

    • Author(s)
      Eto Y, Shen JS, Meng XL, Ohashi T.
    • Journal Title

      J Inherit Metab Dis. 27(3)

      Pages: 411-415

    • Data Source
      KAKENHI-PROJECT-15390328
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrcts CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, ori_T, _Umezawa A, Ohashi T, Eto Y
    • Journal Title

      Gene Ther 11(19)

      Pages: 1475-1481

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Widespread gene transduction to the central nervous system by adenovirus in utero : Implication for prenatal gene therapy to brain involvement of lysosomal storage disease2004

    • Author(s)
      Shen JS, Meng XL, Maeda H, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med 6(11)

      Pages: 1206-1215

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Brain transplantation of genetically modified bone marrow stromal cells corrects CNS pathology and cognitive function in MPS VII mice.2004

    • Author(s)
      Sakurai K, Iizuka S, Shen JS, Meng XL, Mori T, Umezawa A, Ohashi T, Eto Y.
    • Journal Title

      Gene Ther. 11(19)

      Pages: 1475-1481

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Adenoviral gene transfer of GDNF, BDNF and TGFβ2, but not CNTF, cardiotrophin-1 or IGF1, protects injured adult motoneurons after facial nerve avulsion.2003

    • Author(s)
      Sakamoto T, Kawazoe Y, Shen J-S, Takeda Y, Arakawa Y, Ogawa J, Oyanagi K, Ohashi T, Watanabe K, Inoue K, Eto Y, Watabe K.
    • Journal Title

      J Neurosci Res 72

      Pages: 54-64

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] Braintransplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse.2003

    • Author(s)
      Meng XL, Shen JS, Ohashi T, Maeda H, Kim SU, Eto Y.
    • Journal Title

      J Neurosci Res. 74(2)

      Pages: 266-277

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370252
  • [Journal Article] Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils.2003

    • Author(s)
      Hakuba N, Watabe K, Hyodo J, Ohashi T, Eto Y, Taniguchi M, Yang L, Tanaka J, Hata R, Gyo K.
    • Journal Title

      Gene Ther 10

      Pages: 426-433

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] Establishment and characterization of spontaneously immortalized Schwann cells from murine model of globoid cell leukodystrophy (Twitcher).2002

    • Author(s)
      Shen J-S, Watabe K, Meng XL, Ida H, Ohashi T, Eto Y.
    • Journal Title

      J Neurosci Res 68

      Pages: 588-594

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Journal Article] Widespread and highly persistent gene transfer to the CNS by retrovirus vector in utero : Implication for gene therapy to Krabbe disease.

    • Author(s)
      Shen J-S, Meng X-L, Yokoo T, Sakurai K, Watabe K, Ohashi T, Eto Y.
    • Journal Title

      J Gene Med (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14570627
  • [Presentation] MPS II型もdルマウス脳病変における、免疫寛容導入療法併用大量酵素補充療法の効果2017

    • Author(s)
      横井健太郎、横井貴之、嶋田洋太、樋口孝、小林博司、大橋十也、井田博幸
    • Organizer
      日本先天代謝異常学会
    • Data Source
      KAKENHI-PROJECT-15K09600
  • [Presentation] 免疫寛容導入による効果的ポンペ病酵素補充療法の開発

    • Author(s)
      大橋十也 嶋田洋太 樋口孝 飯塚佐代子 井田博幸 衞藤義勝 小林博司
    • Organizer
      第56回日本先天代謝異常学会
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-13 – 2014-11-15
    • Data Source
      KAKENHI-PROJECT-24591526
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  • 2.  ETO Y. (50056909)
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  • 3.  HASEGAWA Yoriyasu (60256435)
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  • 19.  小林 正久 (20312019)
    # of Collaborated Projects: 2 results
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  • 20.  MAEDA Kazuhiro (50548849)
    # of Collaborated Projects: 1 results
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  • 21.  KUROSAWA Kenji (20277031)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TANAKA T (50110929)
    # of Collaborated Projects: 1 results
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  • 23.  OKAMOTO Aikou (20204026)
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    # of Collaborated Projects: 1 results
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  • 25.  KAWANO Hitoshi (20161341)
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    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 29.  TADA Yuki (10179707)
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  • 30.  TAHARA Takahiro (80159029)
    # of Collaborated Projects: 1 results
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