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Kobara Hisanori  小原 久典

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小原 久典  コバラ ヒサノリ

KOBARA Hisanori  小原 久典

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Researcher Number 30598818
Affiliation (Current) 2025: 信州大学, 学術研究院医学系(医学部附属病院), 講師
Affiliation (based on the past Project Information) *help 2022 – 2023: 信州大学, 学術研究院医学系, 助教
2017 – 2019: 信州大学, 学術研究院医学系, 助教
2014 – 2015: 信州大学, 学術研究院医学系, 助教
2013: 信州大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Obstetrics and gynecology
Except Principal Investigator
Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords
Principal Investigator
婦人科腫瘍学 / がん幹細胞マーカー / CD44 variant / NRF2 / 明細胞癌 / 卵巣癌 / 抗酸化物質 / 酸化ストレス / CD133 / CD44 … More / 酸化ストレス耐性 / 卵巣明細胞癌 / 卵巣子宮内膜症性嚢胞 / Lipocalin2 / 浸潤能 酸素濃度 / E-cadherin / 酸素濃度 / 浸潤能 / 妊娠初期 / MMP-9活性 / 絨毛外トロフォブラスト / lipocalin2 … More
Except Principal Investigator
鑑別診断 / 臨床鑑別診断 / 子宮頸部多発嚢胞 / 子宮頸部胃型粘液性癌 / 傍神経浸潤 / 深層学習 / 人工知能 / MRI / 分葉状頸管腺過形成 / 子宮頸部胃型腺癌 / 子宮頸部多発のう胞 / 造腫瘍能 / マイクロアレイ / 癌幹細胞マーカー / 抗癌剤耐性 / 子宮内膜癌 / lipocalin2 Less
  • Research Projects

    (4 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (8 People)
  •  Research on differential diagnosis of cervical multi-cystic lesions by artificial intelligence

    • Principal Investigator
      宮本 強
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56040:Obstetrics and gynecology-related
    • Research Institution
      Shinshu University
  •  Elucidation of the mechanism of oxidative stress tolerance by Lipocalin2 in ovarian clear cell carcinoma and development of treatment methodsPrincipal Investigator

    • Principal Investigator
      Kobara Hisanori
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Shinshu University
  •  Study for development of the therapy targeting the novel oncogene lipocalin2 in endometrial carcinoma

    • Principal Investigator
      MIYAMOTO Tsutomu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Shinshu University
  •  The expression and function of LCN2 in the extravillous trophoblastPrincipal Investigator

    • Principal Investigator
      KOBARA Hisanori
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Shinshu University

All 2022 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Biology and management of lobular endocervical glandular hyperplasia2022

    • Author(s)
      Miyamoto Tsutomu、Kobara Hisanori、Shiozawa Tanri
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 48 Issue: 12 Pages: 3056-3067

    • DOI

      10.1111/jog.15441

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K09593
  • [Journal Article] Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells.2016

    • Author(s)
      Miyamoto T, Kashima H, Yamada Y, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Mvunta DH, Shiozawa T
    • Journal Title

      PLoS One

      Volume: 11 Issue: 5 Pages: e0155220-e0155220

    • DOI

      10.1371/journal.pone.0155220

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25293339
  • [Journal Article] Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant.2016

    • Author(s)
      Yamada Y, Miyamoto T, Kashima H, Kobara H, Asaka R, Ando H, Higuchi S, Ida K, Shiozawa T.
    • Journal Title

      Free Radic Res.

      Volume: 50 Issue: 4 Pages: 414-25

    • DOI

      10.3109/10715762.2015.1134795

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25861484, KAKENHI-PROJECT-25293339
  • [Journal Article] Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target.2015

    • Author(s)
      Asaka R, Miyamoto T, Yamada Y, Ando H, Mvunta DH, Kobara H, Shiozawa T
    • Journal Title

      Lab Invest

      Volume: 95 Issue: 12 Pages: 1363-73

    • DOI

      10.1038/labinvest.2015.119

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K10710, KAKENHI-PROJECT-15K10711, KAKENHI-PROJECT-15K10712, KAKENHI-PROJECT-25293339
  • [Journal Article] Recurrent low-grade endometrial stromal sarcoma with intracaval and intracardiac tumor thrombus: diagnosis, treatment, and surgical management2014

    • Author(s)
      Miyamoto T, Tachibana R, Kobara H, Takano T, Kato H, Shimizu A, Ohya A, Uehara T, Shiozawa T.
    • Journal Title

      International Cancer Conference Journal

      Volume: 3 Issue: 1 Pages: 1-7

    • DOI

      10.1007/s13691-013-0134-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25670699, KAKENHI-PROJECT-25861483
  • [Journal Article] 妊娠初期に診断し保存的に治療し得た腹腔妊娠の1例2014

    • Author(s)
      今西 俊明, 宮本 強, 古川 哲平, 岡 賢二, 鹿島 大靖, 橘 涼太, 小原 久典, 芦田 敬, 近藤 沙織, 塩沢 丹里
    • Journal Title

      関東連合産科婦人科学会誌

      Volume: 51 Pages: 125-131

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25861483
  • [Journal Article] Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia.2013

    • Author(s)
      Kobara H, Miyamoto T, Suzuki A, Asaka R, Yamada Y, Ishikawa K, Kikuchi N, Ohira S, Shiozawa T.
    • Journal Title

      Placenta

      Volume: 34(11) Issue: 11 Pages: 1036-43

    • DOI

      10.1016/j.placenta.2013.08.004

    • Data Source
      KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-24659724, KAKENHI-PROJECT-24659725, KAKENHI-PROJECT-24791696, KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25670698, KAKENHI-PROJECT-25861483, KAKENHI-PROJECT-25861484
  • [Journal Article] Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factor.2013

    • Author(s)
      Miyamoto T
    • Journal Title

      Histopathology

      Volume: Feb 9 [Epub ahead of print] Issue: 7 Pages: 986-93

    • DOI

      10.1111/his.12107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390310, KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-24659724, KAKENHI-PROJECT-24659725, KAKENHI-PROJECT-24791696, KAKENHI-PROJECT-25293339, KAKENHI-PROJECT-25293340, KAKENHI-PROJECT-25861483
  • [Journal Article] Placental mesenchymal dysplasia: chronological observation of placental images during gestation and review of the literature.2013

    • Author(s)
      Ohira S, Ookubo N, Tanaka K, Takatsu A, Kobara H, Kikuchi N, Ohya A, Kanai M, Shiozawa T
    • Journal Title

      Gynecol Obstet Invest

      Volume: 75(4) Issue: 4 Pages: 217-23

    • DOI

      10.1159/000350661

    • NAID

      120007107419

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592442, KAKENHI-PROJECT-25460794, KAKENHI-PROJECT-25670698, KAKENHI-PROJECT-25861483
  • [Presentation] 同一症例の分葉状頸管腺過形成と胃型粘液性癌と全エクソーム配列による解析2022

    • Author(s)
      宮本 強, 田中 泰裕, 井田 耕一, 小原 久典, 山田 靖, 品川 真奈花, 小野 元紀, 浅香 亮一, 塩沢 丹里
    • Organizer
      日本産科婦人科学会学術講演会
    • Data Source
      KAKENHI-PROJECT-22K09593
  • [Presentation] Lipocalin2は妊娠初期絨毛外トロフォブラストの細胞浸潤能を促進する2013

    • Author(s)
      小原久典、宮本 強、菊地範彦、石川香織、山田 靖、浅香亮一、鈴木昭久、大平哲史、塩沢丹里
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-25861483
  • [Presentation] Lipocalin2は子宮内膜癌において新規癌遺伝子として作用する2013

    • Author(s)
      宮本 強、山田 靖、浅香亮一、安藤大史、石川香織、小原久典、鈴木昭久、塩沢丹里
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25293339
  • [Presentation] 鉄運搬に関わるLipocalin2は、子宮内膜癌で新規がん遺伝子として機能する2013

    • Author(s)
      宮本 強、浅香亮一、山田 靖、小原久典、石川香織、鈴木昭久、塩沢丹里
    • Organizer
      第65回日本産科婦人科学会学術講演会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-25293339
  • [Presentation] Lipocalin2 accelerates tumor growth and functions as a novel onvogene in endometrial carcinoma cell.2013

    • Author(s)
      Miyamoto T,Yamada Y,Kobara H,Asaka R,Ando H,Ishikawa K,David Hamisi Mvunta,Suzuki A,Shiozawa T.
    • Organizer
      第3回アジア婦人科腫瘍学会・第55回日本婦人科腫瘍学会学術講演会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-25293339
  • [Presentation] Lipocalin2は低酸素環境でMMP-9活性と絨毛外トロフォブラストの浸潤を亢進させる

    • Author(s)
      小原久典、宮本 強、浅香亮一、山田 靖、塩沢丹里
    • Organizer
      第19回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      大阪 千里ライフサイエンスセンター
    • Year and Date
      2014-08-08 – 2014-08-09
    • Data Source
      KAKENHI-PROJECT-25861483
  • [Presentation] Lipocalin2,an iron transporter,functions as a novel oncogene and enhances the proliferation and survival of endometrial carcinoma cell

    • Author(s)
      Miyamoto T,Asaka R, Yamada Y,Ishikawa k, Kobara H,Suzuki A,Shiozawa T.
    • Organizer
      American Assosiation for Cancer Research Annual Meeting 2013
    • Place of Presentation
      ワシントンD.C(アメリカ)
    • Data Source
      KAKENHI-PROJECT-25293339
  • 1.  MIYAMOTO Tsutomu (70418721)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 2.  SHIOZAWA Tanri (20235493)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 12 results
  • 3.  YAMADA Yasushi (60646652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 4.  鹿島 大靖 (70464089)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  小野 元紀 (10816432)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  大彌 歩 (60837079)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SUZUKI Akihisa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  TAKATSU Akiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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