SHIEN KAZUHIKO 枝園和彦

… Alternative Names

SHIEN Kazuhiko 枝園和彦

枝園和彦シエンカズヒコ

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Researcher Number	30708079
Other IDs
Affiliation (Current)	2025: 岡山大学, 医療開発領域, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 岡山大学, 大学病院, 講師 2016 – 2020: 岡山大学, 大学病院, 助教 2019: 岡山大学, 大学病院, 客員研究員 2017: 岡山大学, 医歯薬学総合研究科, 助教 2015: 岡山大学, 大学院医歯薬学総合研究科, 助教 2013: 岡山大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related / Respiratory surgery / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Respiratory surgery / Basic Section 50010:Tumor biology-related / Basic Section 55010:General surgery and pediatric surgery-related / Tumor biology
Keywords	Principal Investigator 非小細胞肺がん / がん微小環境 / 薬剤耐性 / マルチオミクス解析 / 微小環境 / EGFR / 非小細胞肺癌 / ディスバイオーシス / メタゲノム解析 / COPD … More / 空間解析 / iPS細胞 / オルガノイド / 肺がん / 炎症性サイトカイン / 分子標的薬 / 薬剤反応性 / トランスレーショナルリサーチ / 癌 / マイクロRNA … More Except Principal Investigator 肺癌 / 薬剤耐性 / がん関連線維芽細胞 / がん微小環境 / 炎症 / EGFR / 線溶阻害因子 / 空間解析 / 腫瘍免疫 / B細胞 / 腫瘍免疫療法 / TLS / 腫瘍浸潤B細胞 / 空間マルチオミクス解析 / 血管内皮細胞 / マトリセルラー蛋白 / マトリセルラータンパク質 / 非小細胞肺がん / 肉腫肺転移 / 腫瘍微小環境 / 肺腺癌 / 腫瘍免疫応答 / 内在性レトロウイルス / HER2 / TDM1 / 耐性化機序 / 乳癌 / 胸部悪性腫瘍 / 抗体療法 / 癌微小環境 / EGFR遺伝子変異 / LRIG1 / 転移 / S100A8/A9受容体 / S100A8/A9 / がん / 外科 / 癌 / 次世代シーケンサー / 分子標的治療薬 / 非小細胞肺癌 / PDX / EMT / 次世代シークエンサー / 分子バーコード / 分子標的薬 / 上皮成長因子受容体チロシンキナーゼ阻害薬 / 上皮間葉移行 / 上皮成長因子受容体チロシンキナーゼ阻害剤 / 癌幹細胞 / 原発性肺癌 Less

樹状細胞の活性化を介した抗腫瘍免疫応答の増強による新規肺腺癌治療戦略の基礎的検討
- Principal Investigator
  
  土生智大
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Clarification of spatiotemporal diversity in tumor microenvironment promoting lung metastases from bone and soft tissue sarcoma
- Principal Investigator
  
  山本寛斉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Shimane University
Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancerPrincipal Investigator
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Functional analysis of TLS, tumor-infiltrating B-cell, by spatial multi-omics profiling and its application to tumor immunotherapy
- Principal Investigator
  
  冨田秀太
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
メタゲノム解析によるCOPD合併肺がんの臓器横断的ディスバイオーシスの解明Principal Investigator
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
Elucidation of Tumor Microenvironment Network Regulated by Fibrinolysis Inhibitory Factor and Its Therapeutic Application
- Principal Investigator
  
  伊達慶一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
耐性化機序に基づいたHER2陽性乳癌に対する治療戦略の開発
- Principal Investigator
  
  枝園忠彦
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Okayama University
Clarification of the mechanism for endogenous retrovirus to get involved in the antitumor immunity response
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
マトリセルラータンパク質阻害によるがん微小環境の破壊と抗腫瘍効果の検討
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Novel therapeutic approaches for lung cancer by using iPS cell-derived organoidsPrincipal Investigator
- Principal Investigator
  
  Shien Kazuhiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Novel therapeutic strategy focused on EGFR-binding protein LRIG1 for EGFR-mutant lung cancer
- Principal Investigator
  
  Yamamoto Hiromasa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
Development of innovative therapeutic antibodies targeting the inflammatory tumor microenvironment in refractory thoracic tumors
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal Investigator
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Mechanistic analysis of an unidentified downstream signals of S100A8/A9 receptors that play a crucial role in acquisition of metastatic force and formation of cancer microenvironment.
- Principal Investigator
  
  Sakaguchi Masakiyo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Okayama University
Development of new therapeutic strategy based on gene expression and mutation profiles in EGFR mutant lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
EGFR-TKI resistance and epigenetic alterations in lung cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Shien Kazuhiko
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University

All 2023 2022 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Patent

[Journal Article] Correction to: Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023
- Author(s)
  Takatsu Fumiaki、Suzawa Ken、Tomida Shuta、Thu Yin Min、Sakaguchi Masakiyo、Toji Tomohiro、Ohki Masayoshi、Tsudaka Shimpei、Date Keiichi、Matsuda Naoki、Iwata Kazuma、Zhu Yidan、Nakata Kentaro、Shien Kazuhiko、Yamamoto Hiromasa、Nakayama Akiko、Okazaki Mikio、Sugimoto Seiichiro、Toyooka Shinichi
- Journal Title
  
  Journal of Molecular Medicine
  
  Volume: 102 Issue: 1 Pages: 147-147
- DOI
  10.1007/s00109-023-02408-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24421, KAKENHI-PROJECT-23K27439
[Journal Article] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023
- Author(s)
  Takatsu F, Suzawa K, Tomida S, Thu YM, Sakaguchi M, Shien K, Yamamoto H, Nakayama A, Okazaki M, Sugimoto S, Toyooka S
- Journal Title
  
  Journal of molecular medicine (Berlin, Germany)
  
  Volume: 101 Issue: 12 Pages: 1603-1614
- DOI
  10.1007/s00109-023-02384-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04923, KAKENHI-PROJECT-23K27439, KAKENHI-PROJECT-23K27688
[Journal Article] Identification of genetic loci associated with renal dysfunction after lung transplantation using an ethnic-specific single-nucleotide polymorphism array2023
- Author(s)
  Tomioka Yasuaki、Sugimoto Seiichiro、Yamamoto Haruchika、Tomida Shuta、Shiotani Toshio、Tanaka Shin、Shien Kazuhiko、Suzawa Ken、Miyoshi Kentaroh、Otani Shinji、Yamamoto Hiromasa、Okazaki Mikio、Yamane Masaomi、Toyooka Shinichi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 8912-8912
- DOI
  10.1038/s41598-023-36143-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08974, KAKENHI-PROJECT-23K27688
[Journal Article] Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.2019
- Author(s)
  Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
- Journal Title
  
  Neoplasia.
  
  Volume: 21(7) Issue: 7 Pages: 627-640
- DOI
  10.1016/j.neo.2019.04.006
- NAID
  120006948963
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08276, KAKENHI-PROJECT-19K07369, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
[Journal Article] Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.2019
- Author(s)
  Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M
- Journal Title
  
  Cancer Lett.
  
  Volume: - Pages: 178-190
- DOI
  10.1016/j.canlet.2019.03.023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-19K07369, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
[Journal Article] Anti-tumor effect of neratinib against lung cancer cells harboring HER2 oncogene alterations.2019
- Author(s)
  Ogoshi Y, Shien K, Yoshioka T, Torigoe H, Sato H, Sakaguchi M, Tomida S, Namba K, Kurihara E, Takahashi Y, Suzawa K, Yamamoto H, Soh J, Toyooka S
- Journal Title
  
  Oncol Lett.
  
  Volume: - Pages: 2729-2736
- DOI
  10.3892/ol.2019.9908
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16K10681
[Journal Article] Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression.2019
- Author(s)
  Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M
- Journal Title
  
  Mol Carcinog.
  
  Volume: - Issue: 6 Pages: 980-995
- DOI
  10.1002/mc.22987
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-19K07369, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
[Journal Article] Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer2019
- Author(s)
  Kurihara Eisuke、Shien Kazuhiko、Torigoe Hidejiro、Takeda Tatsuaki、Takahashi Yuta、Ogoshi Yusuke、Yoshioka Takahiro、Namba Kei、Sato Hiroki、Suzawa Ken、Yamamoto Hiromasa、Soh Junichi、Okazaki Mikio、Shien Tadahiko、Tomida Shuta、Toyooka Shinichi
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 4 Pages: 1767-1775
- DOI
  10.21873/anticanres.13283
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16608
[Journal Article] Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells2019
- Author(s)
  Namba Kei、Shien Kazuhiko、Takahashi Yuta、Torigoe Hidejiro、Sato Hiroki、Yoshioka Takahiro、Takeda Tatsuaki、Kurihara Eisuke、Ogoshi Yusuke、Yamamoto Hiromasa、Soh Junichi、Tomida Shuta、Toyooka Shinichi
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 17 Issue: 2 Pages: 499-507
- DOI
  10.1158/1541-7786.mcr-18-0628
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16H05431, KAKENHI-PROJECT-17K16608
[Journal Article] Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naive lung adenocarcinoma2019
- Author(s)
  Namba Kei、Tomida Shuta、Matsubara Takehiro、Takahashi Yuta、Kurihara Eisuke、Ogoshi Yusuke、Yoshioka Takahiro、Takeda Tatsuaki、Torigoe Hidejiro、Sato Hiroki、Shien Kazuhiko、Yamamoto Hiromasa、Soh Junichi、Tsukuda Kazunori、Toyooka Shinichi
- Journal Title
  
  BMC Cancer
  
  Volume: 19 Issue: 1 Pages: 1-9
- DOI
  10.1186/s12885-019-5374-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PROJECT-16H05431
[Journal Article] Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma2018
- Author(s)
  Sato Hiroki、Sakaguchi Masakiyo、Yamamoto Hiromasa、Tomida Shuta、Aoe Keisuke、Shien Kazuhiko、Yoshioka Takahiro、Namba Kei、Torigoe Hidejiro、Soh Junichi、Tsukuda Kazunori、Tao Hiroyuki、Okabe Kazunori、Miyoshi Shinichiro、Pass Harvey I.、Toyooka Shinichi
- Journal Title
  
  Oncogenesis
  
  Volume: 7 Issue: 1 Pages: 11-11
- DOI
  10.1038/s41389-017-0017-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-17H03577
[Journal Article] Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer.2018
- Author(s)
  Sato H, Yamamoto H, Sakaguchi M, Shien K, Tomida S, Shien T, Ikeda H, Hatono M, Torigoe H, Namba K, Yoshioka T, Kurihara E, Ogoshi Y, Takahashi Y, Soh J, Toyooka S
- Journal Title
  
  Cancer Sci.
  
  Volume: 109 Issue: 10 Pages: 3183-3196
- DOI
  10.1111/cas.13763
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03577
[Journal Article] Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations2018
- Author(s)
  Torigoe Hidejiro、Shien Kazuhiko、Takeda Tatsuaki、Yoshioka Takahiro、Namba Kei、Sato Hiroki、suzawa Ken、Yamamoto Hiromasa、Soh Junichi、Sakaguchi Masakiyo、Tomida Shuta、Tsukuda Kazunori、Miyoshi Shinichiro、Toyooka Shinichi
- Journal Title
  
  Cancer Sci.
  
  Volume: - Issue: 5 Pages: 1493-1502
- DOI
  10.1111/cas.13571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17K16608
[Journal Article] Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR2018
- Author(s)
  Torigoe H, Yamamoto H, Sakaguchi M, Youyi C, Numba K, Sato H, Shien K, Soh J, Suzawa K, Tomida S, Tsukuda K, Miyoshi S, Toyooka S
- Journal Title
  
  Carcinogenesis
  
  Volume: - Issue: 5 Pages: 719-727
- DOI
  10.1093/carcin/bgy044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-18K08783
[Journal Article] Newly developed anti-S100A8/A9 monoclonal antibody efficiently prevents lung tropic cancer metastasis.2018
- Author(s)
  Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.
- Journal Title
  
  Int J Cancer.
  
  Volume: 印刷中 Issue: 2 Pages: 569-575
- DOI
  10.1002/ijc.31982
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16K08728, KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-19K07676, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
[Journal Article] exSSSRs (extracellular S100 soil sensor receptors)-Fc fusion proteins work as prominent decoys to S100A8/A9-induced lung tropic cancer metastasis.2018
- Author(s)
  Kinoshita R, Sato H, Yamauchi A, Takahashi Y, Inoue Y, Sumardika IW, Chen Y, Tomonobu N, Araki K, Shien K, Tomida S, Torigoe H, Namba K, Kurihara E, Ogoshi Y, Murata H, Yamamoto KI, Futami J, Putranto EW, Ruma IMW, Yamamoto H, Soh J, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M
- Journal Title
  
  Int J Cancer.
  
  Volume: - Issue: 12 Pages: 3138-3145
- DOI
  10.1002/ijc.31945
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16K08728, KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-19K07474, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-18K15320
[Journal Article] ｂ-1,3-galactosyl-O-glycosyl-glycoprotein ｂ-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.2017
- Author(s)
  Sumardika I Wayan、Youyi Chen、Kondo Eisaku、Inoue Yusuke、Ruma I Made Winarsa、Murata Hitoshi、Kinoshita Rie、Yamamoto Ken-Ichi、Tomida Shuta、Shien Kazuhiko、Satoh Hiroki、Yamauchi Akira、Futami Junichiro、Putranto Endy Widya、Hibino Toshihiko、Toyooka Shinichi、Nishibori Masahiro、Sakaguchi Masakiyo
- Journal Title
  
  Oncology Reserch
  
  Volume: in press Issue: 3 Pages: 431-444
- DOI
  10.3727/096504017x15031557924123
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16K15245, KAKENHI-PROJECT-16K18440, KAKENHI-PROJECT-16K08728, KAKENHI-PROJECT-15K10201, KAKENHI-PROJECT-18K15320
[Journal Article] Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies2017
- Author(s)
  Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y, Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S.
- Journal Title
  
  Anticancer Res
  
  Volume: 14 Pages: 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03577
[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.2017
- Author(s)
  Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 40847-40847
- DOI
  10.1038/srep40847
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-16H06988, KAKENHI-PROJECT-15K19935
[Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015
- Author(s)
  Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Yuichiro Miyoshi, Tomoaki Ohtsuka, Ken Suzawa, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Journal Title
  
  Cancer Science
  
  Volume: 10 Issue: 10 Pages: 1377-1384
- DOI
  10.1111/cas.12749
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293302
[Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.2015
- Author(s)
  Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S
- Journal Title
  
  Oncology Reports
  
  Volume: 33 Issue: 3 Pages: 1499-1504
- DOI
  10.3892/or.2015.3735
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791462, KAKENHI-PROJECT-25293302
[Patent] 抗S100A8/A9抗体とその用途2019
- Inventor(s)
  阪口政清、豊岡伸一、冨田秀太、枝園和彦、木下理恵　他
- Industrial Property Rights Holder
  岡山大学、新潟大学、群馬大学、川崎学園
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H03577
[Presentation] 空間マルチオミクス解析を駆使した肺がんドライバー遺伝子異常と微小環境との相互作用の解明2023
- Author(s)
  枝園和彦, 大亀正義, 冨田秀太, 松岡篤志, 吉川真生, 諏澤憲, 山本寛斉, 岡崎幹生, 杉本誠一郎, 遠西大輔, 豊岡伸一
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27687
[Presentation] 空間トランスクリプトーム解析による間質性肺炎合併肺癌の病態解明2023
- Author(s)
  大亀正義, 枝園和彦, 松岡篤志, 冨田秀太, 東原朋諒, 向原史晃, 林直宏. 土生智大, 吉川真生, 諏澤憲, 山本寛斉, 遠西大輔, 豊岡伸一
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27687
[Presentation] Periostin secreted by cancer-associated fibroblasts promotes cancer progression and drug resistance in non-small cell lung cancer2023
- Author(s)
  Mao Yoshikawa, Ken Suzawa, Fumiaki Takatsu, Tomohiro Habu, Kazuma Iwata, Masayoshi Ohki, Naoki Matsuda, Yin Min Zhu, Kazuhiko Shien, Hiromasa Yamamoto, Shinichi Toyooka
- Organizer
  AACR ANNUAL MEETING 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24421
[Presentation] ショットガンメタゲノム解析を用いた難治性肺がんマイクロバイオームの解明2023
- Author(s)
  松岡篤志、枝園和彦、大亀正義、冨田秀太、田中真、橋本好平、諏澤憲、三好健太郎、山本寛斉、岡崎幹生、杉本誠一郎、遠西大輔、豊岡伸一
- Organizer
  第64回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-23K18317
[Presentation] Periostin secreted by cancer-associated fibroblast promotes cancer progression and drug resistance in non-small cell lung cancer2022
- Author(s)
  Ken Suzawa, Shuta Tomida, Kazuhiko Shien, Hiromasa Yamamoto, and Shinichi Toyooka
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K24421
[Presentation] Activation of AXL as a preclinical acquired resistance mechanism against osimertinib treatment in EGFR-mutant non-small cell lung cancer cells2019
- Author(s)
  Kei Namba, Kazuhiko Shien, Yuta Takahashi, Hiroki Sato, Takahiro Yoshioka, Ken Suzawa, Hiromasa Yamamoto, Junichi Soh, Shuta Tomida, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Clinicopathological characteristics of lung cancer patients with concomitant idiopathic pulmonary fibrosis2019
- Author(s)
  Kota Araki, Kazuhiko Shien, Shunsaku Miyauchi, Akihiro Miura, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Kei Namba, Ken Suzawa, Hiromasa Yamamoto, Shuta Tomida, Junichi Soh, Masakiyo Sakaguchi, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19581
[Presentation] Potent anti-tumor effect of ganetespib in acquired EGFR-TKI resistance NSCLC cells2018
- Author(s)
  Eisuke Kurihara, Kazuhiko Shien, Hidejiro Torigoe, Yuta Takahashi, Yusuke Ogoshi, Takahiro Yoshioka, Kei Namba, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Shinichi Toyooka
- Organizer
  IASLC 19th World Conference on Lung Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] Acquired resistance mechanisms to afatinib in lung cancer cells harboring HER2 alterations2018
- Author(s)
  Hidejiro Torigoe, Kazuhiko Shien, Tatsuaki Takeda, Takahiro Yoshioka, Kei Namba, Hiroki Sato, Ken Suzawa, Hiromasa Yamamoto, Junichi Soh, Masakiyo Sakaguchi, Shuta Tomida, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] Tumor-suppressive effect of LRIG1 in non-small cell lung cancer harboring mutant EGFR2018
- Author(s)
  鳥越英次郎、山本寛斎、阪口政清、難波圭、佐藤博紀、枝園和彦、諏澤憲、宗淳一、冨田秀太、佃和憲、三好新一郎、豊岡伸一
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17H03577
[Presentation] Ganetespib demonstrates strong anti-tumor effect in acquired EGFR-TKI resistance NSCLC cells2018
- Author(s)
  Eisuke Kurihara, Kazuhiko Shien, Hidejiro Torigoe, Yuta Takahashi, Yusuke Ogoshi, Takahiro Yoshioka, Kei Namba, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Shinichi Toyooka
- Organizer
  AACR Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] 第3世代EGFR-TKI Osimertinib耐性肺癌細胞株における獲得耐性機構の解明2017
- Author(s)
  難波圭, 枝園和彦, 吉岡貴裕, 鳥越英次郎, 佐藤博紀, 山本寛斉, 宗淳一, 浅野博昭, 佃和憲, 豊岡伸一
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] HER2遺伝子異常肺癌に対するマルチキナーゼ阻害剤Afatinb耐性獲得機序の解明2017
- Author(s)
  鳥越英次郎, 枝園和彦, 吉岡貴裕, 難波圭, 佐藤博紀, 山本寛斉, 宗淳一, 浅野博昭, 冨田秀太, 佃和憲, 豊岡伸一
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] Multiple acquired resistance mechanisms against third generation EGFR-TKI osimertinib in non-small cell lung cancer cells2017
- Author(s)
  Kei Namba, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] 分子標的薬への耐性機構の解明肺がんにおける分子標的薬耐性メカニズムの解明2017
- Author(s)
  枝園和彦, 佐藤博紀, 鳥越英次郎, 難波圭, 吉岡貴裕, 山本寛斉, 宗淳一, 豊岡伸一
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2017
- Author(s)
  Kei Namba, Shuta Tomida, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016
- Author(s)
  Kei Namba, Shuta Tomida, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第57回日本肺癌学会総会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Targeting miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2016
- Author(s)
  Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  IASCL World Congress on Lung Cancer 2016
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06988
[Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015
- Author(s)
  Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka
- Organizer
  AACR 106th Annual Meeting
- Place of Presentation
  米国
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda,Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] The molecular characters of acquired resistant non－small cell lung cancer cells to afatinib
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyosh
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25293302

1. Toyooka Shinichi (30397880)

# of Collaborated Projects: 15 results

# of Collaborated Products: 29 results
2. 冨田秀太 (10372111)

# of Collaborated Projects: 13 results

# of Collaborated Products: 23 results
3. YAMAMOTO Hiromasa (40467733)

# of Collaborated Projects: 12 results

# of Collaborated Products: 16 results
4. 諏澤憲 (90839713)

# of Collaborated Projects: 11 results

# of Collaborated Products: 7 results
5. SOH Junichi (90559890)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
6. Sakaguchi Masakiyo (70379840)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
7. 冨樫庸介 (80758326)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 遠西大輔 (20825096)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
9. MIYOSHI Shinichiro (00190827)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
10. MATSUDA Fumihiko (50212220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUKUDA Kazunori (20346430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. ASANO Hiroaki (70534775)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. 山本健一 (00711798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
14. 木下理恵 (40518297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. 村田等 (90579096)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
16. 枝園忠彦 (30509451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 本田知之 (80402676)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 土生智大 (00974859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 匹田貴夫 (00437005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 中山雅敬 (70740918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 中田英二 (10649304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 岡崎幹生 (50467750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 細野祥之 (60820363)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 大橋圭明 (60729193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 山中玲子 (00379760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 伊達慶一 (30974860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. SATO Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
28. SUGIMOTO Seiichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. KONDO Eisaku

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 村上孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 橘逸勢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIEN KAZUHIKO 枝園 和彦

SHIEN Kazuhiko 枝園 和彦

枝園 和彦 シエン カズヒコ

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Development of a novel therapeutic strategy targeting the microenvironment that tolerates the progression of refractory lung cancerPrincipal Investigator

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メタゲノム解析によるCOPD合併肺がんの臓器横断的ディスバイオーシスの解明Principal Investigator

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Novel therapeutic approaches for lung cancer by using iPS cell-derived organoidsPrincipal Investigator

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がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal Investigator

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SHIEN KAZUHIKO 枝園和彦

SHIEN Kazuhiko 枝園和彦

枝園和彦シエンカズヒコ