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SHIEN Kazuhiko  枝園 和彦

ORCIDConnect your ORCID iD *help
Researcher Number 30708079
Other IDs
Affiliation *help 2016 – 2017 : 岡山大学, 大学病院, 助教
2015 : 岡山大学, 大学院医歯薬学総合研究科, 助教
2013 : 岡山大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field
Principal Investigator
Respiratory surgery
Except Principal Investigator
Respiratory surgery / Tumor biology
Keywords
Principal Investigator
EGFR / 薬剤耐性 / マイクロRNA / 分子標的薬 / 非小細胞肺癌 / 肺がん / 癌 / 炎症性サイトカイン / トランスレーショナルリサーチ / 薬剤反応性 … More
Except Principal Investigator
… More 薬剤耐性 / 肺癌 / 分子標的薬 / 非小細胞肺癌 / 外科 / 炎症 / 転移 / PDX / 分子バーコード / EGFR / 原発性肺癌 / 癌 / 癌幹細胞 / EMT / がん / 次世代シーケンサー / 上皮成長因子受容体チロシンキナーゼ阻害剤 / 上皮間葉移行 / 分子標的治療薬 / 上皮成長因子受容体チロシンキナーゼ阻害薬 Less
  • Research Projects

    (5results)
  • Research Products

    (8results)
  • Co-Researchers

    (13People)
  •  がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal InvestigatorOngoing

    • Principal Investigator
      枝園 和彦
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University
  •  新規S100受容体による原発巣転移前がん微小環境構築とがん転移動力獲得の分子機構Ongoing

    • Principal Investigator
      阪口 政清
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor biology
    • Research Institution
      Okayama University
  •  遺伝子発現と変異プロファイル解析に基づくEGFR変異肺癌に対する新規治療法の開発Ongoing

    • Principal Investigator
      豊岡 伸一
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University
  •  EGFR-TKI resistance and epigenetic alterations in lung cancer treatmentPrincipal Investigator

    • Principal Investigator
      Shien Kazuhiko
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Research Activity start-up
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University
  •  Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer

    • Principal Investigator
      Toyooka Shinichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory surgery
    • Research Institution
      Okayama University

All 2017 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.2017

    • Author(s)
      Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
    • Journal Title

      Sci Rep.

      Volume : 7 Pages : 40847-40847

    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-16H06988, KAKENHI-PROJECT-15K19935
  • [Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015

    • Author(s)
      Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Yuichiro Miyoshi, Tomoaki Ohtsuka, Ken Suzawa, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
    • Journal Title

      Cancer Science

      Volume : 10 Pages : 1377-1384

    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293302
  • [Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.2015

    • Author(s)
      Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S
    • Journal Title

      Oncology Reports

      Volume : 33 Pages : 1499-1504

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24791462, KAKENHI-PROJECT-25293302
  • [Presentation] Targeting miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2016

    • Author(s)
      Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
    • Organizer
      IASCL World Congress on Lung Cancer 2016
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-12-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H06988
  • [Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016

    • Author(s)
      Kei Namba, Shuta Tomida, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
    • Organizer
      第57回日本肺癌学会総会
    • Place of Presentation
      福岡市
    • Year and Date
      2016-12-19
    • Data Source
      KAKENHI-PROJECT-16H05431
  • [Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015

    • Author(s)
      Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka
    • Organizer
      AACR 106th Annual Meeting
    • Place of Presentation
      米国
    • Year and Date
      2015-04-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293302
  • [Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014

    • Author(s)
      Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda,Shinichiro Miyoshi
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, California, U.S.A
    • Data Source
      KAKENHI-PROJECT-25293302
  • [Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib

    • Author(s)
      Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyosh
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, California, U.S.A
    • Year and Date
      2014-04-05 – 2014-04-09
    • Data Source
      KAKENHI-PROJECT-25293302
  • 1.  Toyooka Shinichi (30397880)
    # of Collaborated Projects : 4results
    # of Collaborated Products : 8results
  • 2.  冨田 秀太 (10372111)
    # of Collaborated Projects : 3results
    # of Collaborated Products : 4results
  • 3.  SOH Junichi (90559890)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 6results
  • 4.  YAMAMOTO Hiromasa (40467733)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 7results
  • 5.  MIYOSHI Shinichiro (00190827)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 5results
  • 6.  阪口 政清 (70379840)
    # of Collaborated Projects : 2results
    # of Collaborated Products : 0results
  • 7.  MATSUDA Fumihiko (50212220)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 8.  TSUKUDA Kazunori (20346430)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 5results
  • 9.  ASANO Hiroaki (70534775)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 5results
  • 10.  山本 健一 (00711798)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 11.  木下 理恵 (40518297)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 12.  村田 等 (90579096)
    # of Collaborated Projects : 1results
    # of Collaborated Products : 0results
  • 13.  SATO Hiroki
    # of Collaborated Projects : 1results
    # of Collaborated Products : 2results

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