SHIEN Kazuhiko 枝園和彦

Researcher Number	30708079
Other IDs
Affiliation *help	2016 – 2018 : 岡山大学, 大学病院, 助教 2015 : 岡山大学, 大学院医歯薬学総合研究科, 助教 2013 : 岡山大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Respiratory surgery Except Principal Investigator Respiratory surgery / Tumor biology / Basic Section 55040:Respiratory surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator EGFR / 薬剤耐性 / マイクロRNA / 分子標的薬 / 非小細胞肺癌 / 肺がん / 癌 / 炎症性サイトカイン / トランスレーショナルリサーチ / 薬剤反応性 … More Except Principal Investigator … More

EGFR結合蛋白LRIG1に着目した、EGFR変異陽性肺癌に対する新規治療戦略Ongoing
- Principal Investigator
  
  山本寛斉
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
難治性胸部悪性腫瘍の炎症性癌微小環境を標的とした画期的抗体療法Ongoing
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal InvestigatorOngoing
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
新規S100受容体による原発巣転移前がん微小環境構築とがん転移動力獲得の分子機構Ongoing
- Principal Investigator
  
  阪口政清
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Okayama University
遺伝子発現と変異プロファイル解析に基づくEGFR変異肺癌に対する新規治療法の開発Ongoing
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
EGFR-TKI resistance and epigenetic alterations in lung cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Shien Kazuhiko
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University

All 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2017
- Author(s)
  Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
- Journal Title
  
  Scientific Reports
  
  Volume : 7 Pages : 40847-40847
- DOI
  10.1038/srep40847
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-16H06988, KAKENHI-PROJECT-15K19935
[Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015
- Author(s)
  Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Yuichiro Miyoshi, Tomoaki Ohtsuka, Ken Suzawa, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Journal Title
  
  Cancer Science
  
  Volume : 10 Pages : 1377-1384
- DOI
  10.1111/cas.12749
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293302
[Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015
- Author(s)
  Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S
- Journal Title
  
  Oncology Reports
  
  Volume : 33 Pages : 1499-1504
- DOI
  10.3892/or.2015.3735
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791462, KAKENHI-PROJECT-25293302
[Presentation] Targeting miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2016
- Author(s)
  Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  IASCL World Congress on Lung Cancer 2016
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06988
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016
- Author(s)
  Kei Namba, Shuta Tomida, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第57回日本肺癌学会総会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015
- Author(s)
  Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka
- Organizer
  AACR 106th Annual Meeting
- Place of Presentation
  米国
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda,Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] The molecular characters of acquired resistant non－small cell lung cancer cells to afatinib
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyosh
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25293302

1. Toyooka Shinichi (30397880)

# of Collaborated Projects : 6results

# of Collaborated Products : 8results
2. 冨田秀太 (10372111)

# of Collaborated Projects : 5results

# of Collaborated Products : 4results
3. SOH Junichi (90559890)

# of Collaborated Projects : 4results

# of Collaborated Products : 6results
4. YAMAMOTO Hiromasa (40467733)

# of Collaborated Projects : 4results

# of Collaborated Products : 7results
5. MIYOSHI Shinichiro (00190827)

# of Collaborated Projects : 2results

# of Collaborated Products : 5results
6. 阪口政清 (70379840)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. MATSUDA Fumihiko (50212220)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. TSUKUDA Kazunori (20346430)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
9. ASANO Hiroaki (70534775)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
10. 山本健一 (00711798)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 木下理恵 (40518297)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. 村田等 (90579096)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. SATO Hiroki

# of Collaborated Projects : 1results

# of Collaborated Products : 2results

SHIEN Kazuhiko 枝園 和彦

Research Projects

Research Products

Co-Researchers

EGFR結合蛋白LRIG1に着目した、EGFR変異陽性肺癌に対する新規治療戦略Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性胸部悪性腫瘍の炎症性癌微小環境を標的とした画期的抗体療法Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規S100受容体による原発巣転移前がん微小環境構築とがん転移動力獲得の分子機構Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子発現と変異プロファイル解析に基づくEGFR変異肺癌に対する新規治療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EGFR-TKI resistance and epigenetic alterations in lung cancer treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015

Author(s)

Journal Title

DOI

Data Source

[Presentation] Targeting miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014

SHIEN Kazuhiko 枝園和彦