SHIEN Kazuhiko 枝園和彦

Researcher Number	30708079
Other IDs
Affiliation *help	2016 – 2018 : 岡山大学, 大学病院, 助教 2017 : 岡山大学, 医歯薬学総合研究科, 助教 2015 : 岡山大学, 大学院医歯薬学総合研究科, 助教 2013 : 岡山大学, 医歯(薬)学総合研究科, 助教
Review Section/Research Field	Principal Investigator Respiratory surgery Except Principal Investigator Respiratory surgery / Tumor biology / Basic Section 55040:Respiratory surgery-related / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Keywords	Principal Investigator 非小細胞肺癌 / EGFR / 薬剤耐性 / マイクロRNA / トランスレーショナルリサーチ / 肺がん / がん微小環境 / 癌 / 分子標的薬 / 炎症性サイトカイン / 薬剤反応性 … More Except Principal Investigator … More

EGFR結合蛋白LRIG1に着目した、EGFR変異陽性肺癌に対する新規治療戦略Ongoing
- Principal Investigator
  
  山本寛斉
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Okayama University
難治性胸部悪性腫瘍の炎症性癌微小環境を標的とした画期的抗体療法Ongoing
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Okayama University
新規S100受容体による原発巣転移前がん微小環境構築とがん転移動力獲得の分子機構Ongoing
- Principal Investigator
  
  阪口政清
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Okayama University
がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal InvestigatorOngoing
- Principal Investigator
  
  枝園和彦
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
遺伝子発現と変異プロファイル解析に基づくEGFR変異肺癌に対する新規治療法の開発Ongoing
- Principal Investigator
  
  豊岡伸一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
EGFR-TKI resistance and epigenetic alterations in lung cancer treatmentPrincipal Investigator
- Principal Investigator
  
  Shien Kazuhiko
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Research Activity start-up
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University
Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer
- Principal Investigator
  
  Toyooka Shinichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory surgery
- Research Institution
  Okayama University

All 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma2018
- Author(s)
  Sato Hiroki、Sakaguchi Masakiyo、Yamamoto Hiromasa、Tomida Shuta、Aoe Keisuke、Shien Kazuhiko、Yoshioka Takahiro、Namba Kei、Torigoe Hidejiro、Soh Junichi、Tsukuda Kazunori、Tao Hiroyuki、Okabe Kazunori、Miyoshi Shinichiro、Pass Harvey I.、Toyooka Shinichi
- Journal Title
  
  Oncogenesis.
  
  Volume : 7 Pages : 11-11
- DOI
  10.1038/s41389-017-0017-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10784, KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-17H03577
[Journal Article] Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations2018
- Author(s)
  Torigoe Hidejiro、Shien Kazuhiko、Takeda Tatsuaki、Yoshioka Takahiro、Namba Kei、Sato Hiroki、suzawa Ken、Yamamoto Hiromasa、Soh Junichi、Sakaguchi Masakiyo、Tomida Shuta、Tsukuda Kazunori、Miyoshi Shinichiro、Toyooka Shinichi
- Journal Title
  
  Cancer Sci.
  
  Volume : -
- DOI
  10.1111/cas.13571
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03577
[Journal Article] Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR2018
- Author(s)
  Torigoe H, Yamamoto H, Sakaguchi M, Youyi C, Numba K, Sato H, Shien K, Soh J, Suzawa K, Tomida S, Tsukuda K, Miyoshi S, Toyooka S
- Journal Title
  
  Carcinogenesis
  
  Volume : -
- DOI
  10.1093/carcin/bgy044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03577
[Journal Article] Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies2017
- Author(s)
  Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y, Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S.
- Journal Title
  
  Anticancer Res
  
  Volume : 14 Pages : 301-307
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03577
[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2017
- Author(s)
  Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S.
- Journal Title
  
  Scientific Reports
  
  Volume : 7 Pages : 40847-40847
- DOI
  10.1038/srep40847
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-16H01574, KAKENHI-PROJECT-16H06988, KAKENHI-PROJECT-15K19935
[Journal Article] ｂ-1,3-galactosyl-O-glycosyl-glycoprotein ｂ-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.2017
- Author(s)
  Sumardika IW, Youyi C, Kondo E, Inoue Y, Ruma IM, Murata H, Kinoshita R, Yamamoto, KI, Tomida S, Shien K, Satoh H, Yamauchi A, Futami J, Putranto EW, Hibino T, Toyooka S, Nishibori M, and Sakaguchi M.
- Journal Title
  
  Oncology Reserch
  
  Volume : -
- DOI
  10.3727/096504017x15031557924123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08728, KAKENHI-PROJECT-16K19037, KAKENHI-PROJECT-17H03577, KAKENHI-PROJECT-17H03590, KAKENHI-PROJECT-16K15245, KAKENHI-PROJECT-16K18440
[Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015
- Author(s)
  Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Yuichiro Miyoshi, Tomoaki Ohtsuka, Ken Suzawa, Mototsugu Watanabe, Yuho Maki, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Journal Title
  
  Cancer Science
  
  Volume : 10 Pages : 1377-1384
- DOI
  10.1111/cas.12749
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293302
[Journal Article] Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015
- Author(s)
  Hashida S, Yamamoto H, Shien K, Ohtsuka T, Suzawa K, Maki Y, Furukawa M, Soh J, Asano H, Tsukuda K, Miyoshi S, Kanazawa S, Toyooka S
- Journal Title
  
  Oncology Reports
  
  Volume : 33 Pages : 1499-1504
- DOI
  10.3892/or.2015.3735
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24791462, KAKENHI-PROJECT-25293302
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2017
- Author(s)
  Kei Namba, Shuta Tomida, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Multiple acquired resistance mechanisms against third generation EGFR-TKI osimertinib in non-small cell lung cancer cells2017
- Author(s)
  Kei Namba, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichi Toyooka
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] HER2遺伝子異常肺癌に対するマルチキナーゼ阻害剤Afatinb耐性獲得機序の解明2017
- Author(s)
  鳥越英次郎, 枝園和彦, 吉岡貴裕, 難波圭, 佐藤博紀, 山本寛斉, 宗淳一, 浅野博昭, 冨田秀太, 佃和憲, 豊岡伸一
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] 分子標的薬への耐性機構の解明肺がんにおける分子標的薬耐性メカニズムの解明2017
- Author(s)
  枝園和彦, 佐藤博紀, 鳥越英次郎, 難波圭, 吉岡貴裕, 山本寛斉, 宗淳一, 豊岡伸一
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] 第3世代EGFR-TKI Osimertinib耐性肺癌細胞株における獲得耐性機構の解明2017
- Author(s)
  難波圭, 枝園和彦, 吉岡貴裕, 鳥越英次郎, 佐藤博紀, 山本寛斉, 宗淳一, 浅野博昭, 佃和憲, 豊岡伸一
- Organizer
  第58回日本肺癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16608
[Presentation] Targeting miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2016
- Author(s)
  Kazuhiko Shien, Hiroki Sato, Ken Suzawa, Shuta Tomida, Shinsuke Hashida, Hiromasa Yamamoto, Junichi Soh, Hidejiro Torigoe, Kei Namba, Mototsugu Watanabe, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  IASCL World Congress on Lung Cancer 2016
- Place of Presentation
  Vienna, Austria
- Year and Date
  2016-12-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06988
[Presentation] Detection of multiple low-frequency mutations by molecular-barcode sequencing2016
- Author(s)
  Kei Namba, Shuta Tomida, Kazuhiko Shien, Hidejiro Torigoe, Hiroki Sato, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka
- Organizer
  第57回日本肺癌学会総会
- Place of Presentation
  福岡市
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-16H05431
[Presentation] Effect of Hsp90 inhibitor NVP-AUY922 with radiation on lung adenocarcinoma cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors2015
- Author(s)
  Yuho Maki, Shinsuke Hashida, Hiromasa Yamamoto, Kazuhiko Shien, Tomoaki Ohtsuka, Ken Suzawa, Masashi Furukawa, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyoshi, Susumu Kanazawa, Shinichi Toyooka
- Organizer
  AACR 106th Annual Meeting
- Place of Presentation
  米国
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] The molecular characters of acquired resistant non-small cell lung cancer cells to afatinib2014
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda,Shinichiro Miyoshi
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Data Source
  KAKENHI-PROJECT-25293302
[Presentation] The molecular characters of acquired resistant non－small cell lung cancer cells to afatinib
- Author(s)
  Shinsuke Hashida, Shinichi Toyooka, Tomoaki Ohtsuka, Ken Suzawa, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Hiroaki Asano, Kazunori Tsukuda, Shinichiro Miyosh
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, California, U.S.A
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25293302

1. Toyooka Shinichi (30397880)

# of Collaborated Projects : 6results

# of Collaborated Products : 15results
2. 冨田秀太 (10372111)

# of Collaborated Projects : 5results

# of Collaborated Products : 10results
3. SOH Junichi (90559890)

# of Collaborated Projects : 4results

# of Collaborated Products : 9results
4. YAMAMOTO Hiromasa (40467733)

# of Collaborated Projects : 4results

# of Collaborated Products : 9results
5. MIYOSHI Shinichiro (00190827)

# of Collaborated Projects : 2results

# of Collaborated Products : 5results
6. 阪口政清 (70379840)

# of Collaborated Projects : 2results

# of Collaborated Products : 5results
7. MATSUDA Fumihiko (50212220)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
8. TSUKUDA Kazunori (20346430)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
9. ASANO Hiroaki (70534775)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
10. 山本健一 (00711798)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
11. 木下理恵 (40518297)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
12. 村田等 (90579096)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
13. SATO Hiroki

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
14. 井上裕介

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
15. 近藤英作

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

SHIEN Kazuhiko 枝園 和彦

Research Projects

Research Products

Co-Researchers

EGFR結合蛋白LRIG1に着目した、EGFR変異陽性肺癌に対する新規治療戦略Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性胸部悪性腫瘍の炎症性癌微小環境を標的とした画期的抗体療法Ongoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規S100受容体による原発巣転移前がん微小環境構築とがん転移動力獲得の分子機構Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

がん微小環境における炎症性サイトカインに着目した肺がん分子標的薬治療抵抗性の克服Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子発現と変異プロファイル解析に基づくEGFR変異肺癌に対する新規治療法の開発Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EGFR-TKI resistance and epigenetic alterations in lung cancer treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Understanding and overcoming drug resistance to EGFR-inhibitors for lung cancer

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Therapeutic strategies for afatinib-resistant lung cancer harboring HER2 alterations2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies2017

Author(s)

Journal Title

Data Source

[Journal Article] Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ｂ-1,3-galactosyl-O-glycosyl-glycoprotein ｂ-1,6-N-acetylglucosaminyltransferase 3 Increases MCAM Stability, Which Enhances S100A8/A9-Mediated Cancer Motility.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib2015

Author(s)

Journal Title

DOI

Data Source

SHIEN Kazuhiko 枝園和彦

[Presentation] 分子標的薬への耐性機構の解明肺がんにおける分子標的薬耐性メカニズムの解明2017