Yokoi Satoshi 横井聡

Researcher Number	30815460
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科(保健), 准教授 2025: 名古屋大学, 医学系研究科, 特任助教
Affiliation (based on the past Project Information) *help	2024 – 2025: 名古屋大学, 医学系研究科(保健), 准教授 2021 – 2023: 名古屋大学, 医学系研究科, 特任助教 2018 – 2020: 名古屋大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Basic Section 52020:Neurology-related Except Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields
Keywords	Principal Investigator CRISPR/Cas9 / iPS細胞 / シナプス / FUS / 筋萎縮性側索硬化症 / iPS細胞由来運動神経 / アンチセンスオリゴ / シナプス機能 / ALS / SynGAP … More Except Principal Investigator … More 筋萎縮性側索硬化症 / iPS細胞 / シヌクレイン / 運動ニューロン / 球脊髄性筋萎縮症 / 脂質代謝異常 / アストロサイト / オミクス解析 / プロテオーム解析 / リバーストランスレーショナルリサーチ / オリゴデンドロサイト / TDP-43 / 神経変性 / タンパク質凝集体 / ポリグルタミン / タンパク質凝集 / 核酸 / 神経変性疾患 / 凝集タンパク質 / 低分子干渉RNA / アンチセンス核酸 / TDP-43ノックインマウス / TDP-43凝集阻害 / ALS / コリントランスポーター / 声帯麻痺 / ノックインマウス / SLC5A7 / 遠位型遺伝性運動ニューロパチー / コホート / シナプス / トランスオミックス / カルシウムイメージング / 視覚野 / 嗅球 / 神経回路 / レビー小体病型認知症 / 神経活動 / 幻視 / レビー小体型認知症 / パーキンソン病 / α-シヌクレイン / 軸索 / 脊髄性筋萎縮症 / 運動ニューロン疾患 Less

患者血漿プロテオーム解析とiPS細胞を用いた筋萎縮性側索硬化症の病態解析
- Principal Investigator
  
  伊藤大輔
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
球脊髄性筋萎縮症の運動ニューロン病態におけるアストロサイト脂質代謝異常の役割
- Principal Investigator
  
  飯田円
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
孤発性ALS病態を反映した動物モデル作成とTDP-43凝集抑制療法の開発
- Principal Investigator
  
  井口洋平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
ALSに関連する運動ニューロン周囲オリゴデンドロサイトの機能と役割の解明
- Principal Investigator
  
  井口洋平
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Understanding of early axonal pathology in motor neuron diseases
- Principal Investigator
  
  Sahashi Kentaro
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  横井聡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Reserch to dicover disease pathogenesis of distal hereditary motor neuropathy
- Principal Investigator
  
  Iguchi Yohei
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Therapeutic development against protein aggregation
- Principal Investigator
  
  佐橋健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Nagoya University
Wide-field Ca imaging and trans-omics for mouse model of Lewy body disease
- Principal Investigator
  
  Katsuno Masahisa
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Nagoya University
Study of pathogenic mechanism of amyotrophic lateral sclerosis through excessive recrutiment of RNA-binding protein FUSPrincipal Investigator
- Principal Investigator
  
  Yokoi Satoshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University
Study of the pathogenesis of ALS toward the novel synaptic proteinPrincipal Investigator
- Principal Investigator
  
  Yokoi Satoshi
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Nagoya University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies.2024
- Author(s)
  Fukami Y, Iijima M, Koike H, Yagi S, Furukawa S, Mouri N, Ouchida J, Murakami A, Iida M, Yokoi S, Hashizume A, Iguchi Y, Imagama S, Katsuno M.
- Journal Title
  
  Neurol Neuroimmunol Neuroinflamm.
  
  Volume: 11(2) Issue: 2
- DOI
  10.1212/nxi.0000000000200199
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14751, KAKENHI-PROJECT-23K06926, KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-22K15705
[Journal Article] IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation2024
- Author(s)
  Iguchi Yohei、Takahashi Yuhei、Li Jiayi、Araki Kunihiko、Amakusa Yoshinobu、Kawakami Yu、Kobayashi Kenta、Yokoi Satoshi、Katsuno Masahisa
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 223 Issue: 2
- DOI
  10.1083/jcb.202302048
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19506, KAKENHI-PROJECT-22K15707
[Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022
- Author(s)
  Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y*, Sobue G*
- Journal Title
  
  Journal of Neuroscience
  
  Volume: 42 Issue: 47 Pages: 8881-8896
- DOI
  10.1523/jneurosci.0455-22.2022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07539, KAKENHI-PROJECT-19K07969, KAKENHI-PROJECT-19K07973, KAKENHI-PROJECT-21K07471, KAKENHI-PROJECT-22K07509, KAKENHI-PROJECT-22K07515, KAKENHI-PROJECT-22K07545, KAKENHI-PROJECT-20K16611, KAKENHI-PROJECT-21K15622, KAKENHI-PROJECT-17K19465, KAKENHI-PROJECT-18K15470, KAKENHI-PROJECT-19H03576, KAKENHI-PROJECT-23K24249, KAKENHI-PROJECT-23K21410
[Presentation] Simple and efficient scarless genome-editing in patient-derived lymphoblastoid cell lines2023
- Author(s)
  Satoshi Yokoi, Ryoichi Nakamura, Genki Tohnai, Naoki Atsuta, Yohei Okada, Gen Sobue, Masahisa Katsuno
- Organizer
  第64回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K07515
[Presentation] Analysis of visual abnormalities in synucleinopathy2022
- Author(s)
  天草善信, 井口洋平, 横井聡, 川上裕, 勝野雅央
- Organizer
  第63回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-22K19506
[Presentation] The SYNGAP1 3’UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022
- Author(s)
  Satoshi Yokoi
- Organizer
  2022 Cold Spring Harbor meeting: Translational Control
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07515
[Presentation] An ALS patient SynGAP 3’UTR variant at the FUS binding site causes aberrant SynGAP splicing and spine abnormalities by recruiting hnRNPK2021
- Author(s)
  横井聡, 伊藤卓治, 佐橋健太郎, 中村亮一, 石垣診祐, 熱田直樹、勝野雅央, 岡田洋平,祖父江元
- Organizer
  PACTALS 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16489
[Presentation] SynGAP 3'UTR mutation from ALS cohort causes aberrant FUS-SynGAP mRNA regulation and spine formation2021
- Author(s)
  横井聡, 伊藤卓治, 佐橋健太郎, 中村亮一, 石垣診祐, 熱田直樹、勝野雅央, 岡田洋平,祖父江元
- Organizer
  第62回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16489
[Presentation] SynGAP 3'UTR mutation from ALS cohort causes aberrant FUS-SynG AP mRNA regulation and spine formation2020
- Author(s)
  Satoshi Yokoi, Takuji Ito, Kentaro Sahashi, Ryoichi Nakamura, Shinsuke Ishigaki, Naoki Atsuta, Masahisa Katsuno, Yohei Okada, Gen Sobue
- Organizer
  第61回日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-20K16489
[Presentation] FUS depletion induces spine abnormality and SynGAP depletion in hiPSC-derived motor neuron2019
- Author(s)
  Satoshi Yokoi, Takuji Ito, Kentaro Sahashi, Shinsuke Ishigaki, Masahisa Katsuno, Yohei Okada, Gen Sobue
- Organizer
  第60回日本神経学会学術集会
- Data Source
  KAKENHI-PROJECT-18K15362

1. Katsuno Masahisa (50402566)

# of Collaborated Projects: 9 results

# of Collaborated Products: 3 results
2. Iguchi Yohei (80790659)

# of Collaborated Projects: 7 results

# of Collaborated Products: 3 results
3. Sahashi Kentaro (90710103)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. 蛭薙智紀 (00927527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 飯田円 (40815437)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 伊藤大輔 (20879944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 深見祐樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 岡田洋平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 伊藤卓治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yokoi Satoshi 横井 聡

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Study of synaptic pahtology caused by FUS in amyotrophic lateral sclerosisPrincipal Investigator

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Study of pathogenic mechanism of amyotrophic lateral sclerosis through excessive recrutiment of RNA-binding protein FUSPrincipal Investigator

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Study of the pathogenesis of ALS toward the novel synaptic proteinPrincipal Investigator

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[Journal Article] Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies.2024

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[Journal Article] IκB kinase phosphorylates cytoplasmic TDP-43 and promotes its proteasome degradation2024

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[Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022

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[Presentation] Simple and efficient scarless genome-editing in patient-derived lymphoblastoid cell lines2023

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Yokoi Satoshi 横井聡