KIMOTO Masao 木本雅夫

… Alternative Names

木本雅夫キモトマサオ

Less

Researcher Number	40153225
Affiliation (based on the past Project Information) *help	2009 – 2012: 佐賀大学, 医学部, 教授 2003 – 2007: 佐賀大学, 医学部, 教授 1998 – 2002: 佐賀医科大学, 医学部, 教授 1992 – 1996: 佐賀医科大学, 医学部, 教授 1992: 佐賀医科大学, 医学部 1987 – 1990: 佐賀医科大学, 医学部, 教授 1986: 佐賀医大, 医学部, 教授
Review Section/Research Field	Principal Investigator Immunology / Immunology / 免疫の制御機構 Except Principal Investigator Hematology / 膠原病・アレルギー・感染症内科学 / Human pathology
Keywords	Principal Investigator LPS / B / MD-2 / WF1マウス / クラスII分子 / トランスジェニックマウス / 融合蛋白 / LBP / CD14 / アイソフォーム … More / CD43 / ペプチドモチーフ / T細胞クローン / 結合ペプチドモチーフ / 自己ペプチド / 自己抗原ペプチド / F1マウス / BW / アイソタイプ / モノクロ-ナル抗体 / T細胞クロ-ン / pCAGG-S1 vector / epitope / NF κ B reporter gene / E coli expression / fusion protein / pET32 vector / pCAG-S1ベクター / pCAGG-S1ベクター / エピトープ / NFκBレポーター遺伝子 / 大腸菌発現系 / pET32ベクター / cytokine / ligand / bacterial expression / recombinant protein / トランスフェクタント / キメラ蛋白 / ノックアウト / CHO / 自己抗体 / SLE / MD-1 / 変異蛋白 / 川崎病 / RP105 / TLR4 / リコンピナント蛋白 / サイトカイン / リガンド / 大腸菌発現 / リコンビナント蛋白 / antibody production / helper function / T cell / isoform / C2GnT / 発現調節 / 抗体産生 / ヘルパー活性 / T細胞 / Auto-reactive T cell / Peptide motif / Class II molecule / Mixed haplotype / H-2 complex / WF1 mice / T cell self-antigen epitope / 抗DNA抗体 / ハプロタイプ混合クラスII分子 / MHCクラスII分子 / 自己反応性 / TCR / SCIDマウス / 抗DNA抗原 / 病原性T細胞クローン / ハプロタイプ混合 / 自己反応性T細胞 / H-2 / 自己免疫T細胞エピトープ / 2次元電気泳動 / アイソタイプ混合分子 / ハプロタイプ / H-2複合体 / la分子 / トランスジェニックマウス, Ia,サザンハイブリダイゼーション, 蛍光抗体法 / Ia / 自己トレランス / 新制性細胞 / 同系混合リンパ球反応 / 新生仔マウス胸腺細胞 / 感染防御 / 自然免疫 / 刺激型抗体 / TLR4/MD-2 / 免疫賦活 / 抗体 / 加齢 / 自己免疫疾患の発症 / 陰性荷電を有するアミノ酸 / TCRVβ鎖 / 自己反応性T細胞クローン / cマウス / BALB / TCRレパトリ- / 変異APC / 病原性自己ペプチド / アミノ酸シークエンス / 病原性自己反応性T細胞クローン / AαdクラスII分子 / Aβz / APC変異株 / 自己免疫疾患 / クローン化T細胞 / 自己抗原処理・提示 / MHCクラスII分子変異細胞株 / 変異株 / アロ抗原刺激能 / NOD / 混合 / クラスII / アイソタイプ混合 … More Except Principal Investigator RP105 / BCMA / SLE / 血管内皮 / TLR4 / モノクローナル抗体 / PAR / コラーゲン関節炎 / 自己抗体 / 自己免疫疾患 / B細胞 / Collgeen induced arthritis / Infectious diseases / Autoimmune diseases / Siogren's svdrome / B cells / BAFF / DNAチップ / CD40L / 感染症 / シェーグレン症候群 / inflammation / receptor / endothelial cell / protein C / 受容体 / トロンビン / 炎症 / レセプター / プロテインC / Microalley / Collagen arthritis / Autoantibody / Sjogren's syndrome / Autoimmune disease / B cell / B細胞刺激因子 / アポトーシス / マイクロアレイ / Sjogren症候群 / blood coagulation / monoclonal antibody / endothelial / thrombosis / 血液凝固 / 血栓 / lipoproteins / transgene / transgenic rabbit / animal models / atherosclerosis / hypercholesterolemia / animal cloning / clone / 細胞核融合 / 体細胞クローン / ウサギ / 遺伝子操作 / 動物モデル / リポ蛋白 / 動脈硬化 / 卵細胞活性化 / 単為発生 / トランスジェニックウサギ / クローンウサギ / 体細胞核移植技術 / 抗体 / アゴニスト / 敗血症 / TLR / ストレスシグナル / 粗面小胞体 / 血液免疫学 Less

Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vessel
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAbPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Total analysis of RP105 molecule on B cells : Its function and application to treatment in autoimmune diseases
- Principal Investigator
  
  NAGASAWA Kohei
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saga University
Structural and Functional Analysis of the MD-2 proteinPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Regulation mechanism for inflammation mediated by endothelial cell protein C receptor
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
The importance of the deletion of RP105 on B cells in autoimmune diseases and its application for the treatment
- Principal Investigator
  
  NAGASAWA Kohei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saga University
Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodies
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
  佐賀医科大学
Analysis of pathogen recognition by TLR4 and RP105 and their application to immunothrapyPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Saga University
  佐賀医科大学
DEVELOPMENT OF CLONE TRANSGENIC RABBITS FOR THE STUDY OF ATHEROSCLEROSIS
- Principal Investigator
  
  WATANABE Teruo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  SAGA MEDICAL SCHOOL
  University of Tsukuba
Regulation of the helper T cell function by a novel CD43 isoformPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga Medical School
自己免疫モデルB/WF1マウスT細胞レパトリ-の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  免疫の制御機構
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
変異クラスII分子発現による抗腫瘍T細胞免疫応答の誘導Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  佐賀医科大学
Analysis of T cell self-antigen epitope in auto-immune model B/WF1 mice.Principal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Saga Medical School
NODマウスのクラスII分子,特にアイソタイプ混合AαEβ分子の特異性と機能解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学
クラスII遺伝子導入トランスジェニックマウスの免疫学的解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
la遺伝子導入トランスジェニックマウスの系統化と遺伝的モニタリングPrincipal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
自己Ia反応性T細胞トレランス成立に対するIa分子発現の量的効果の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学
Ia遺伝子導入トランスジェニックマウスの系統化と遺伝的モニタリングPrincipal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
新生仔マウス胸腺内に存在する自己Ia反応性T細胞特異的抑制性細胞の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学

All 2013 2012 2011 2010 2007 2003 Other

All Journal Article Presentation Book

[Book] 医学大辞典.第2版
- Author(s)
  木本雅夫.伊藤正男, 井村裕夫, 高久史麿
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] nhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation2013
- Author(s)
  Nurlaely MR, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Yanagibashi T, Nagai Y, Takatsu K, Ohta S, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume: 25(2) Pages: 117-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2013
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume: 190(1) Pages: 195-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] The RP105/ MD-1 complex is indispensable for TLR4/ MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells2012
- Author(s)
  Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Ohta S, Hirai Y, Kimoto M, Miyake K, Takatsu K.
- Journal Title
  
  Int Immunol
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Arai H, Kadowaki T, Nagai R.: Saturated Fatty Acid and TLR Signaling LinkβCell Dysfunction and Islet Inflammation2012
- Author(s)
  Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R.
- Journal Title
  
  Cell Metab
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume: 22(4) Pages: 271-80
- NAID
  10027392279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010
- Author(s)
  Matsushita H, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K.
- Journal Title
  
  Int Immunol
  
  Volume: 22(9) Pages: 739-47
- NAID
  10030913704
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume: 22(4) Pages: 271-80
- NAID
  10027392279
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis2007
- Author(s)
  Horiuchi T, Kiyohara C, Tsukamoto H, Sawabe T, Furugo I, Yoshizawa S, Ueda A, Tada Y, Kimoto Y, Mitoma H, Harashima S, Yoshizawa S, Shimoda T, Okamura S, Nagasawa K, Harada M.
- Journal Title
  
  Ann Rheum Dis 66
  
  Pages: 320-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591115
[Journal Article] A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus:a case-control study and a meta-analysis2007
- Author(s)
  Horiuchi T, Kiyohara C, Tsukamoto H, Sawabe T, Furugo I, Yoshizawa S, Ueda A, Tada Y, Kimoto Y, Mitoma H, Harashima S, Yoshizawa S, Shimoda T, Okamura S, Nagasawa K, Harada M.
- Journal Title
  
  Ann Rheum Dis 66
  
  Pages: 320-324
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591115
[Journal Article] Role of TLR4/MD-2 and RP105/MD-1 in innate recognition of lipopolysaccharide.2003
- Author(s)
  Kimoto M
- Journal Title
  
  Scand.J.Infect.Dis. 35(9)
  
  Pages: 568-572
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13470073
[Presentation] Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/ MD-2 antibody2011
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
- Organizer
  第40回日本免疫学会
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/MD-2 antibody.2011
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉市
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants2010
- Author(s)
  Rachmawati NM, Uleng B, Fukudome K, Kimoto M
- Organizer
  第14回国際免疫学会議
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants2010
- Author(s)
  Rachmawati NM, Uleng B, Fukudome K, Kimoto M
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Lipopolysaccharidebindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Lipopolysaccharide-bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538

1. FUKUDOME Kenji (50284625)

# of Collaborated Projects: 5 results

# of Collaborated Products: 10 results
2. MIYAKE Kensuke (60229812)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. TSUNEYOSHI Naoko (80336114)

# of Collaborated Projects: 4 results

# of Collaborated Products: 5 results
4. NAGASAWA Kouhei (00108721)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. KOARADA Syuichi (50304887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TADA Yoshifumi (70284627)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
7. TSUKAMOTO Hiroki (70423605)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. WATANABE Teruo (40037396)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. FAN Jianglin (60272192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. WATANABE Keiichi (40191754)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MOTOSHIMA Hiroyuki (20312275)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 井出良浩 (70258606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 長崎比呂央 (50318664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HONDA Kazuo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KIMOTO Masao 木本 雅夫

木本 雅夫 キモト マサオ

Research Projects

Research Products

Co-Researchers

Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vessel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAbPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Total analysis of RP105 molecule on B cells : Its function and application to treatment in autoimmune diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and Functional Analysis of the MD-2 proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation mechanism for inflammation mediated by endothelial cell protein C receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The importance of the deletion of RP105 on B cells in autoimmune diseases and its application for the treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathogen recognition by TLR4 and RP105 and their application to immunothrapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF CLONE TRANSGENIC RABBITS FOR THE STUDY OF ATHEROSCLEROSIS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of the helper T cell function by a novel CD43 isoformPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

自己免疫モデルB/WF1マウスT細胞レパトリ-の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

KIMOTO Masao 木本雅夫

木本雅夫キモトマサオ