KIMOTO Masao 木本雅夫

Researcher Number	40153225
Affiliation *help	2009 – 2012 : 佐賀大学, 医学部, 教授 2003 – 2007 : 佐賀大学, 医学部, 教授 1998 – 2002 : 佐賀医科大学, 医学部, 教授 1992 – 1996 : 佐賀医科大学, 医学部, 教授 1992 : 佐賀医科大学, 医学部 1987 – 1990 : 佐賀医科大学, 医学部, 教授 1986 : 佐賀医大, 医学部, 教授
Review Section/Research Field	Principal Investigator Immunology / Immunology / 免疫の制御機構 Except Principal Investigator Hematology / 膠原病・アレルギー・感染症内科学 / Human pathology
Keywords	Principal Investigator LPS / B / WF1マウス / トランスジェニックマウス / MD-2 / クラスII分子 / T細胞クローン / LBP / 結合ペプチドモチーフ / BW … More Except Principal Investigator RP105 / BCMA / 血管内皮 / SLE / モノクローナル抗体 / TLR4 / PAR / B細胞 / 自己抗体 / コラーゲン関節炎 / 自己免疫疾患 / endothelial / endothelial cell / マイクロアレイ / Infectious diseases / B cells / transgenic rabbit / DNAチップ / hypercholesterolemia / 敗血症 / Sjogren症候群 / 体細胞核移植技術 / 感染症 / ストレスシグナル / 動物モデル / リポ蛋白 / B cell / Siogren's svdrome / lipoproteins / 受容体 / 体細胞クローン / アゴニスト / Autoimmune diseases / アポトーシス / animal cloning / トランスジェニックウサギ / protein C / Collgeen induced arthritis / トロンビン / inflammation / ウサギ / レセプター / 血液凝固 / 細胞核融合 / Autoimmune disease / Autoantibody / TLR / monoclonal antibody / transgene / 粗面小胞体 / 動脈硬化 / clone / atherosclerosis / 血液免疫学 / B細胞刺激因子 / クローンウサギ / 血栓 / CD40L / animal models / 抗体 / receptor / 遺伝子操作 / Collagen arthritis / 単為発生 / BAFF / Microalley / シェーグレン症候群 / thrombosis / Sjogren's syndrome / 炎症 / 卵細胞活性化 / blood coagulation / プロテインC Less

Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vessel
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAbPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Total analysis of RP105 molecule on B cells : Its function and application to treatment in autoimmune diseases
- Principal Investigator
  
  NAGASAWA Kohei
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saga University
Structural and Functional Analysis of the MD-2 proteinPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga University
Regulation mechanism for inflammation mediated by endothelial cell protein C receptor
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
The importance of the deletion of RP105 on B cells in autoimmune diseases and its application for the treatment
- Principal Investigator
  
  NAGASAWA Kohei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Saga University
Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodies
- Principal Investigator
  
  FUKUDOME Kenji
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Saga University
  佐賀医科大学
Analysis of pathogen recognition by TLR4 and RP105 and their application to immunothrapyPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Saga University
  佐賀医科大学
DEVELOPMENT OF CLONE TRANSGENIC RABBITS FOR THE STUDY OF ATHEROSCLEROSIS
- Principal Investigator
  
  WATANABE Teruo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  SAGA MEDICAL SCHOOL
  University of Tsukuba
Regulation of the helper T cell function by a novel CD43 isoformPrincipal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Saga Medical School
自己免疫モデルB/WF1マウスT細胞レパトリ-の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  免疫の制御機構
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1993 – 1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
変異クラスII分子発現による抗腫瘍T細胞免疫応答の誘導Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  佐賀医科大学
Analysis of T cell self-antigen epitope in auto-immune model B/WF1 mice.Principal Investigator
- Principal Investigator
  
  KIMOTO Masao
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Saga Medical School
NODマウスのクラスII分子,特にアイソタイプ混合AαEβ分子の特異性と機能解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学
クラスII遺伝子導入トランスジェニックマウスの免疫学的解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
la遺伝子導入トランスジェニックマウスの系統化と遺伝的モニタリングPrincipal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
自己Ia反応性T細胞トレランス成立に対するIa分子発現の量的効果の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学
Ia遺伝子導入トランスジェニックマウスの系統化と遺伝的モニタリングPrincipal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  佐賀医科大学
新生仔マウス胸腺内に存在する自己Ia反応性T細胞特異的抑制性細胞の解析Principal Investigator
- Principal Investigator
  
  木本雅夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  佐賀医科大学

All 2013 2012 2011 2010 2007 2003 Other

All Journal Article Presentation Book

[Book] 医学大辞典.第2版
- Author(s)
  木本雅夫.伊藤正男, 井村裕夫, 高久史麿
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2013
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume : 190(1) Pages : 195-204
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] nhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation2013
- Author(s)
  Nurlaely MR, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Yanagibashi T, Nagai Y, Takatsu K, Ohta S, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume : 25(2) Pages : 117-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] The RP105/ MD-1 complex is indispensable for TLR4/ MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells2012
- Author(s)
  Nagai Y, Yanagibashi T, Watanabe Y, Ikutani M, Kariyone A, Ohta S, Hirai Y, Kimoto M, Miyake K, Takatsu K.
- Journal Title
  
  Int Immunol
  
  Volume : (in press)
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Arai H, Kadowaki T, Nagai R.: Saturated Fatty Acid and TLR Signaling LinkβCell Dysfunction and Islet Inflammation2012
- Author(s)
  Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R.
- Journal Title
  
  Cell Metab
  
  Volume : (in press)
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M
- Journal Title
  
  Int Immunol
  
  Volume : 22(4) Pages : 271-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591064
[Journal Article] Endotoxin tolerance attenuates airway allergic inflammation in model mice by suppression of the T-cell stimulatory effect of dendritic cells2010
- Author(s)
  Matsushita H, Ohta S, Shiraishi H, Suzuki S, Arima K, Toda S, Tanaka H, Nagai H, Kimoto M, Inokuchi A, Izuhara K.
- Journal Title
  
  Int Immunol
  
  Volume : 22(9) Pages : 739-47
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Journal Title
  
  Int Immunol
  
  Volume : 22(4) Pages : 271-80
- Data Source
  KAKENHI-PROJECT-21590538
[Journal Article] A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis2007
- Author(s)
  Horiuchi T, Kiyohara C, Tsukamoto H, Sawabe T, Furugo I, Yoshizawa S, Ueda A, Tada Y, Kimoto Y, Mitoma H, Harashima S, Yoshizawa S, Shimoda T, Okamura S, Nagasawa K, Harada M.
- Journal Title
  
  Ann Rheum Dis 66
  
  Pages : 320-324
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591115
[Journal Article] A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus:a case-control study and a meta-analysis2007
- Author(s)
  Horiuchi T, Kiyohara C, Tsukamoto H, Sawabe T, Furugo I, Yoshizawa S, Ueda A, Tada Y, Kimoto Y, Mitoma H, Harashima S, Yoshizawa S, Shimoda T, Okamura S, Nagasawa K, Harada M.
- Journal Title
  
  Ann Rheum Dis 66
  
  Pages : 320-324
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591115
[Journal Article] Role of TLR4/MD-2 and RP105/MD-1 in innate recognition of lipopolysaccharide.2003
- Author(s)
  Kimoto M
- Journal Title
  
  Scand.J.Infect.Dis. 35(9)
  
  Pages : 568-572
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13470073
[Presentation] Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/ MD-2 antibody2011
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
- Organizer
  第40回日本免疫学会
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Inhibition of primary but not secondary humoral immune responses by pre-injection of an agonistic anti-TLR4/MD-2 antibody.2011
- Author(s)
  Rachmawati NM, Fukudome K, Tsuneyoshi N, Uleng B, Ohta S, Kimoto M
- Organizer
  第40回日本免疫学会
- Place of Presentation
  千葉市
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Lipopolysaccharidebindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591064
[Presentation] Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants2010
- Author(s)
  Rachmawati NM, Uleng B, Fukudome K, Kimoto M
- Organizer
  第14回国際免疫学会議
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Lipopolysaccharide-bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010
- Author(s)
  Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
- Organizer
  第14回国際免疫学会議
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-21590538
[Presentation] Agonistic anti-TLR4 monoclonal antibodies function as immunoadjuvants2010
- Author(s)
  Rachmawati NM, Uleng B, Fukudome K, Kimoto M
- Organizer
  第14回国際免疫学会議
- Place of Presentation
  神戸市
- Year and Date
  2010-08-27
- Data Source
  KAKENHI-PROJECT-22591064

1. FUKUDOME Kenji (50284625)

# of Collaborated Projects : 5results

# of Collaborated Products : 10results
2. MIYAKE Kensuke (60229812)

# of Collaborated Projects : 4results

# of Collaborated Products : 0results
3. TSUNEYOSHI Naoko (80336114)

# of Collaborated Projects : 4results

# of Collaborated Products : 5results
4. NAGASAWA Kouhei (00108721)

# of Collaborated Projects : 3results

# of Collaborated Products : 2results
5. KOARADA Syuichi (50304887)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. TADA Yoshifumi (70284627)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
7. TSUKAMOTO Hiroki (70423605)

# of Collaborated Projects : 1results

# of Collaborated Products : 2results
8. WATANABE Teruo (40037396)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. FAN Jianglin (60272192)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. WATANABE Keiichi (40191754)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. MOTOSHIMA Hiroyuki (20312275)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
12. 井出良浩 (70258606)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
13. 長崎比呂央 (50318664)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
14. HONDA Kazuo

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

KIMOTO Masao 木本 雅夫

Research Projects

Research Products

Co-Researchers

Pathogen moleculoar pattern recognition mechanisms inside and outsied of the blood vessel

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAbPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Total analysis of RP105 molecule on B cells : Its function and application to treatment in autoimmune diseases

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and Functional Analysis of the MD-2 proteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation mechanism for inflammation mediated by endothelial cell protein C receptor

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The importance of the deletion of RP105 on B cells in autoimmune diseases and its application for the treatment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of regulation of blood coagulation using functional-blocking monoclonal antibodies

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of pathogen recognition by TLR4 and RP105 and their application to immunothrapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

DEVELOPMENT OF CLONE TRANSGENIC RABBITS FOR THE STUDY OF ATHEROSCLEROSIS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of the helper T cell function by a novel CD43 isoformPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

自己免疫モデルB/WF1マウスT細胞レパトリ-の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

MHCクラスII分子変異細胞株を用いた自己抗原処理・提供機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

KIMOTO Masao 木本雅夫