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TSUKAMOTO HIROKI  塚本 宏樹

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TSUKAMOTO Hiroki  塚本 宏樹

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Researcher Number 70423605
Other IDs
Affiliation (Current) 2022: 国際医療福祉大学, 福岡薬学部, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2021: 国際医療福祉大学, 福岡薬学部, 准教授
2016 – 2019: 東北大学, 薬学研究科, 助教
2017: 東北大学, 大学院薬学研究科, 助教
2013 – 2015: 東北大学, 薬学研究科(研究院), 助教
2011 – 2012: 佐賀大学, 医学部, 助教 … More
2007 – 2009: Saga University, 医学部, 助教
2007: 佐賀大, 医学部, 助手
2006: 佐賀大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Drug development chemistry / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy
Except Principal Investigator
Immunology / Tumor diagnostics / Medical pharmacy / Medical Physics and Radiological Technology / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
免疫学 / 抗体 / Toll様受容体 / モノクローナル抗体 / 抗体医薬 / 自然免疫 / 癌 / 薬理学 / シグナル伝達 / 感染症 … More / 薬学 / 生体分子 / TLR4 / MD-2 / リポ多糖 / 敗血症 / 自己免疫疾患 / 1型糖尿病 / 免疫寛容 / 機能性抗体 / 骨髄由来免疫抑制細胞 / Toll-like receptor / 1型糖尿病 / 制御性T細胞 / がん免疫療法 / 免疫チェックポイント / 低分子創薬 / CD73 / アデノシン受容体 / アジュバント / 腫瘍免疫 / PD-L1 / 低分子薬 / アデノシン / PD-1 / 複合がん免疫療法 / 免疫抑制経路阻害薬 / 食物アレルギー / MDSC / IgE / 肥満細胞 … More
Except Principal Investigator
アデノシン / メタボロミクス / CD73 / 抗体 / 免疫賦活 / TLR4/MD-2 / LPS / 刺激型抗体 / 自然免疫 / 感染防御 / 修飾核酸 / がん免疫 / LC/MS / 腫瘍マーカー / 放射線耐性 / プロテオミクス / 脂肪酸合成酵素 / がん細胞 / CD39 / エクソソーム / 化合物ライブラリー / 免疫抑制 / CD73 / CD39 / 免疫制御 Less
  • Research Projects

    (10 results)
  • Research Products

    (110 results)
  • Co-Researchers

    (39 People)
  •  TLR4刺激抗体の食物アレルギー抑制機序解明による新規アレルギー予防・治療戦略Principal Investigator

    • Principal Investigator
      塚本 宏樹
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      International University of Health and Welfare
  •  CD39ーCD73-アデノシンカスケードを制御する分子の探索と創薬への展開

    • Principal Investigator
      富岡 佳久
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tohoku University
  •  Combination cancer immunotherapy with antigen-specific agonistic TLR4 antibody and immune checkpoint inhibitorsPrincipal Investigator

    • Principal Investigator
      TSUKAMOTO HIROKI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
    • Research Institution
      International University of Health and Welfare
      Tohoku University
  •  Investigation of the modified nucleic acid for novel cancer evaluation marker candidates and its diagnostic application.

    • Principal Investigator
      Tomioka Yoshihisa
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Tumor diagnostics
    • Research Institution
      Tohoku University
  •  Elucidation of the mechanism of radioresistance in cancer cells using trans-omics approach and development of clinical biomarkers for radiotherapy.

    • Principal Investigator
      Kanemitsu Yoshitomi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
      Medical Physics and Radiological Technology
    • Research Institution
      Tohoku University
  •  A novel immunotherapy of autoimmune disease by agonistic toll-like receptor 4 antibodyPrincipal Investigator

    • Principal Investigator
      TSUKAMOTO HIROKI
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Tohoku University
  •  Novel regulatory mechanism of human Toll-like receptor 4 function by the inhibitory monoclonal antibodyPrincipal Investigator

    • Principal Investigator
      TSUKAMOTO HIROKI
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Tohoku University
      Saga University
  •  Aanalysis of immune activation and protective mechanisms against infection using agonistic anti-TLR4 mAb

    • Principal Investigator
      KIMOTO Masao
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Saga University
  •  Recognition of lipopolysaccharide by adiponectinPrincipal Investigator

    • Principal Investigator
      TSUKAMOTO Hiroki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Saga University
  •  刺激型抗TLR抗体による新しい癌の治療法の理論構築と創薬開発への応用Principal Investigator

    • Principal Investigator
      塚本 宏樹
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Drug development chemistry
    • Research Institution
      Saga University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2010 2008 2007 2006 Other

All Journal Article Presentation Book Patent

  • [Book] Bioactive Lipid Mediators-Current Reviews and Protocols2015

    • Author(s)
      Takahashi T, Saigusa D, Takeda C, Saito K, Suzuki N, Tsukamoto H, Tomioka Y
    • Total Pages
      426
    • Publisher
      Springer Japan
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Book] Handbook of Glycosyltransferases and Related Genes, 2nd ed2014

    • Author(s)
      Ikeda Y, Ihara H, Tsukamoto H, Gu J, Taniguchi N
    • Total Pages
      1717
    • Publisher
      Springer Japan
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Book] Handbook of Glycosyltransferases and Related Genes, 2nd ed2014

    • Author(s)
      Ihara H, Tsukamoto H, Gu J, Miyoshi E, Taniguchi N, Ikeda Y
    • Total Pages
      1717
    • Publisher
      Springer Japan
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Book] Handbook of Glycosyltransferases and Related Genes, Mannosyl (β-1,4-)-glycoproteinβ-1,4-N-acetylglucosaminyltransferase (MGAT3);β1,4-N-Acetylglucosaminyltransferase III (GnT-III, GlcNAc-T III)(Taniguchi N, Honke K, Fukuda M, Narimatsu H, Yamaguchi Y, Angata T, eds)2014

    • Author(s)
      Ikeda Y, Ihara H, Tsukamoto H, Gu J, Taniguchi N
    • Publisher
      Springer Japan (Tokyo, Japan)
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Book] Handbook of Glycosyltransferases and Related Genes(FUT8), Fucosyltransferase 8. GDP-fucose N-glycan coreα6-fucosyltransferase(Taniguchi N, Honke K, Fukuda M, Narimatsu H, Yamaguchi Y, Angata T, eds)2014

    • Author(s)
      Ihara H, Tsukamoto H, Gu J, Miyoshi E, Taniguchi N, Ikeda Y
    • Publisher
      Springer Japan (Tokyo, Japan)
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Journal Article] Identification of novel biomarkers of hepatocellular carcinoma by high‐definition mass spectrometry: Ultrahigh‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry and desorption electrospray ionization mass spectrometry imaging2020

    • Author(s)
      Nagai, K. et al. Koshiba S. et al. Tomioka Y.(合計17名、本研究者は14番目)
    • Journal Title

      Rapid Communications in Mass Spectrometry

      Volume: 印刷中

    • DOI

      10.1002/rcm.8551

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-17K08233, KAKENHI-PROJECT-18K06651
  • [Journal Article] The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages.2020

    • Author(s)
      Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
    • Journal Title

      International Immunology

      Volume: 32 Pages: 785-798

    • DOI

      10.1093/intimm/dxaa055

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21612, KAKENHI-PUBLICLY-18H04856, KAKENHI-PUBLICLY-20H04900, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-16H06388, KAKENHI-PROJECT-20H03466, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K07169
  • [Journal Article] Impaired antigen‐specific lymphocyte priming in mice after Toll‐like receptor 4 activation via induction of monocytic myeloid‐derived suppressor cells2019

    • Author(s)
      Tsukamoto Hiroki、Kozakai Sao、Kobayashi Yohei、Takanashi Risako、Aoyagi Takuya、Numasaki Muneo、Ohta Shoichiro、Tomioka Yoshihisa
    • Journal Title

      European Journal of Immunology

      Volume: 49 Pages: 546-563

    • DOI

      10.1002/eji.201847805

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Journal Article] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease.2019

    • Author(s)
      Kikuchi Koichi、Saigusa Daisuke、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tsukamoto Hiroki、Abe Takaaki
    • Journal Title

      Nat Commun.

      Volume: 10 Pages: 1385-1385

    • DOI

      10.1038/s41467-019-09735-4

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-18K07076, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PLANNED-17H06394, KAKENHI-PUBLICLY-18H04805, KAKENHI-PROJECT-19H03557, KAKENHI-PROJECT-19H03675, KAKENHI-PROJECT-17K00856
  • [Journal Article] An agonistic anti‐Toll‐like receptor 4 monoclonal antibody as an effective adjuvant for cancer immunotherapy2019

    • Author(s)
      Tsukamoto Hiroki、Kubota Kanae、Shichiku Ayumi、Maekawa Masamitsu、Mano Nariyasu、Yagita Hideo、Ohta Shoichiro、Tomioka Yoshihisa
    • Journal Title

      Immunology

      Volume: 158 Pages: 136-149

    • DOI

      10.1111/imm.13095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Journal Article] Comprehensive and semi-quantitative analysis of carboxyl-containing metabolites related to gut microbiota on chronic kidney disease using 2-picolylamine isotopic labeling LC-MS/MS2019

    • Author(s)
      Kanemitsu Yoshitomi、Mishima Eikan、Maekawa Masamitsu、Matsumoto Yotaro、Saigusa Daisuke、Yamaguchi Hiroaki、Ogura Jiro、Tsukamoto Hiroki、Tomioka Yoshihisa、Abe Takaaki、Mano Nariyasu
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 19075-19075

    • DOI

      10.1038/s41598-019-55600-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-18K06742, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-19K17258
  • [Journal Article] Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1-IKKe-IRF3 axis activation.2018

    • Author(s)
      Tsukamoto Hiroki、Takeuchi Shino、Kubota Kanae、Kobayashi Yohei、Kozakai Sao、Ukai Ippo、Shichiku Ayumi、Okubo Misaki、Numasaki Muneo、Kanemitsu Yoshitomi、Matsumoto Yotaro、Nochi Tomonori、Watanabe Kouichi、Aso Hisashi、Tomioka Yoshihisa
    • Journal Title

      J. Bio. Chem.

      Volume: 293 Pages: 10186-10201

    • DOI

      10.1074/jbc.m117.796631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-17K19882, KAKENHI-PROJECT-18H03969
  • [Journal Article] Generation and Characterization of Anti-phenyl Sulfate Monoclonal Antibodies and a Potential Use for Phenyl Sulfate Analysis in Human Blood2018

    • Author(s)
      Kanemitsu Yoshitomi、Tsukamoto Hiroki、Matsumoto Yotaro、Nozawa-Kumada Kanako、Kondo Yoshinori、Abe Takaaki、Tomioka Yoshihisa
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 41 Issue: 8 Pages: 1170-1177

    • DOI

      10.1248/bpb.b17-00925

    • NAID

      130007429804

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06651, KAKENHI-PROJECT-17K15418
  • [Journal Article] Simultaneous quantitative analysis of uremic toxins by LC-MS/MS with a reversed-phase/cation-exchange/anion-exchange tri-modal mixed-mode column2017

    • Author(s)
      Kanemitsu Yoshitomi、Asaji Kei、Matsumoto Yotaro、Tsukamoto Hiroki、Saigusa Daisuke、Mukawa Chikahisa、Tachikawa Tatsuki、Abe Takaaki、Tomioka Yoshihisa
    • Journal Title

      Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

      Volume: 1068-1069 Pages: 1-8

    • DOI

      10.1016/j.jchromb.2017.10.009

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K20909
  • [Journal Article] Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS?based metabolomics approach2017

    • Author(s)
      †Mishima, E., †Fukuda, S. (†equally contributed), Mukawa, C., Yuri, A., Kanemitsu, Y., Matsumoto, Y., Akiyama, Y., Fukuda, NN., Tsukamoto, H., Asaji, K., Shima, H., Kikuchi, K., Suzuki, T., Tomioka, Y., Soga, T., Ito, S., Abe, T.
    • Journal Title

      Kidney international

      Volume: 92 Pages: 634-645

    • DOI

      10.1016/j.kint.2017.02.011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04901, KAKENHI-PROJECT-16K19474, KAKENHI-PROJECT-16K20909
  • [Journal Article] Rapid and selective simultaneous quantitative analysis of modified nucleosides using multi-column liquid chromatography-tandem mass spectrometry2017

    • Author(s)
      4.Jinno D, Kanemitsu Y, Saitoh K, Nankumo S, Tsukamoto H, Matsumoto Y, Abe T, Tomioka Y
    • Journal Title

      J Anal Sci Technol

      Volume: 8 Pages: 1-9

    • DOI

      10.1186/s40543-017-0110-4

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04704, KAKENHI-PROJECT-26460058
  • [Journal Article] An inhibitory epitope of human Toll-like receptor 4 resides on leucine-rich repeat 13 and is recognized by a monoclonal antibody2017

    • Author(s)
      Tsukamoto Hiroki、Yamagata Yuki、Ukai Ippo、Takeuchi Shino、Okubo Misaki、Kobayashi Yohei、Kozakai Sao、Kubota Kanae、Mumasaki Muneo、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tomioka Yoshihisa
    • Journal Title

      FEBS Letters

      Volume: 591 Pages: 2406-2416

    • DOI

      10.1002/1873-3468.12768

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K20909
  • [Journal Article] A Heterodimeric Cytokine, Consisting of IL-17A and IL-17F, Promotes Migration and Capillary-Like Tube Formation of Human Vascular Endothelial Cells2016

    • Author(s)
      Numasaki M, Tsukamoto H, Tomioka Y, Nishioka Y, Ohrui T.
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 240(1) Issue: 1 Pages: 47-56

    • DOI

      10.1620/tjem.240.47

    • NAID

      130005261734

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-26460058, KAKENHI-PROJECT-26670418, KAKENHI-PROJECT-26460900
  • [Journal Article] Toll様受容体4抑制抗体の作用機序とそのエピトープ2016

    • Author(s)
      塚本宏樹
    • Journal Title

      細胞

      Volume: 48(4) Pages: 50-52

    • Data Source
      KAKENHI-PROJECT-26460058
  • [Journal Article] TEX101, a glycoprotein essential for sperm fertility, is required for stable expression of Ly6k on testicular germ cells.2016

    • Author(s)
      Endo S, Yoshitake H, Tsukamoto H, Matsuura H, Kato K, Sakuraba M, Takamori K, Fujiwara H, Takeda S, Araki Y
    • Journal Title

      Sci.Rep.

      Volume: 6 Pages: 23616-23616

    • DOI

      10.1038/srep23616

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460058, KAKENHI-PROJECT-25460727, KAKENHI-PROJECT-25462575, KAKENHI-PROJECT-16K11111
  • [Journal Article] Antitumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ12016

    • Author(s)
      Hasegawa K, Tagawa M, Takagi K, Tsukamoto H, Tomioka Y, Suzuki T, Nishioka Y, Ohrui T, Numasaki M.
    • Journal Title

      Cancer Gene Ther.

      Volume: 23(8) Pages: 266-277

    • DOI

      10.1038/cgt.2016.29

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-26460058, KAKENHI-PROJECT-26670418, KAKENHI-PROJECT-16K08645
  • [Journal Article] イナビル添加乳糖に夾雑する乳タンパク質によってアナフィラキシーを呈した1例2016

    • Author(s)
      森川みき、金光祥臣、塚本宏樹、富岡佳久
    • Journal Title

      アレルギー

      Volume: 65(3)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Journal Article] Leucine-rich repeat 2 of human Toll-like receptor 4 contains the binding site for inhibitory monoclonal antibodies2015

    • Author(s)
      Tsukamoto H, Ukai I, Yamagata Y, Takeuchi S, Kubota K, Kozakai S, Suzuki N, Kimoto M, Tomioka Y
    • Journal Title

      FEBS Lett

      Volume: 589(24 Pt B) Pages: 3893-3898

    • DOI

      10.1016/j.febslet.2015.11.018

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Journal Article] Reversal of new-onset type 1 diabetes with an agonistic TLR4/MD-2 monoclonal antibody2015

    • Author(s)
      Bednar, K.J., Tsukamoto, H., Kachapati, K., Ohta, S., Wu, Y., Katz, J.D., Ascherman, D.P. & Ridgway, W.M.
    • Journal Title

      Diabetes

      Volume: 64 Pages: 3614-3626

    • DOI

      10.2337/db14-1868

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-26460058
  • [Journal Article] Multi-inhibitory effects of A2A adenosine receptor signaling on neutrophil adhesion under flow2015

    • Author(s)
      Yago T, Tsukamoto H, Liu Z, Wang Y, Thompson LF, McEver RP
    • Journal Title

      J Immunol

      Volume: 195(8) Pages: 3880-3889

    • DOI

      10.4049/jimmunol.1500775

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Journal Article] 【研究戦略・YAKU学~研究現場から~】 機能性抗体によるToll様受容体の活性制御を基盤とした敗血症治療薬開発2015

    • Author(s)
      塚本宏樹
    • Journal Title

      薬事日報

      Volume: 11542 Pages: 8-8

    • Data Source
      KAKENHI-PROJECT-26460058
  • [Journal Article] Immune regulation via the generation of extracellular adenosine by CD732014

    • Author(s)
      Tsukamoto H
    • Journal Title

      Seikagaku

      Volume: 86 Pages: 766-769

    • NAID

      40020314143

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Journal Article] A validated quantitative liquid chromatography-tandem quadrupole mass spectrometry method for monitoring isotopologues to evaluate global modified cytosine ratios in genomic DNA.2014

    • Author(s)
      Tsuji M, Matsunaga H, Jinno D, Tsukamoto H, Suzuki N, Tomioka Y
    • Journal Title

      Journal of Chromatography B

      Volume: 953-954 Pages: 38-47

    • DOI

      10.1016/j.jchromb.2014.01.050

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790112, KAKENHI-PROJECT-25430135, KAKENHI-PROJECT-26460058
  • [Journal Article] Extracellular Adenosine Is a Therapeutic Target for Limiting Graft-<i>versus</i>-Host Disease and Enhancing the Graft-<i>versus</i>-Tumor Effect against Hematopoietic Malignancy2014

    • Author(s)
      Tsukamoto H
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 134 Issue: 10 Pages: 1021-1027

    • DOI

      10.1248/yakushi.14-00184

    • NAID

      130004693882

    • ISSN
      0031-6903, 1347-5231
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Journal Article] Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation2013

    • Author(s)
      Nurlaely Mida Rachmawati, Kenji Fukudome, Naoko Tsuneyoshi, Uleng Bahrun, Hiroki Tsukamoto, Tsutomu Yanagibashi, Yoshinori Nagai, Kiyoshi Takatsu, Shoichiro Ohta, and Masao Kimoto
    • Journal Title

      Int Immunol

      Volume: 25 Pages: 117-128

    • DOI

      10.1093/intimm/dxs096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591466, KAKENHI-PROJECT-24790112, KAKENHI-PUBLICLY-24117708
  • [Journal Article] A Delicate Balance: CD73-generated adenosine limits the severity of graft vs. host disease, but also constrains the allogeneic graft vs. tumor effect2013

    • Author(s)
      Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R
    • Journal Title

      OncoImmunology

      Volume: 2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Journal Article] Difucosylation of chitooligosaccharides by eukaryote and prokaryote a1, 6-fucosyltransferases.2013

    • Author(s)
      Ihara H, Hanashima S, Tsukamoto H, Yamaguchi Y, Taniguchi N, Ikeda Y
    • Journal Title

      Biochim Biophys Acta

      Volume: 1830 Pages: 4482-449

    • DOI

      10.1016/j.bbagen.2013.05.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
  • [Journal Article] Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells2013

    • Author(s)
      Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M
    • Journal Title

      J Immunol

      Volume: 190 Pages: 195-204

    • DOI

      10.4049/jimmunol.1201047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24590577, KAKENHI-PROJECT-24591466, KAKENHI-PROJECT-24790112
  • [Journal Article] MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor 4 with extrinsic soluble MD-2 on the cell surface2013

    • Author(s)
      Tsukamoto H, Ihara H, Ito R, Ukai I, Suzuki N, Kimoto M, Tomioka Y, Ikeda Y
    • Journal Title

      Biochem. Biophys. Res. Comm

      Volume: 440 Pages: 31-36

    • DOI

      10.1016/j.bbrc.2013.09.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112, KAKENHI-PROJECT-25430135
  • [Journal Article] An assay for alpha1, 6-fucosyltransferase (FUT8) activity based on the HPLC separation of a reaction product with fluorescence detection2013

    • Author(s)
      Ihara H, Tsukamoto H, Taniguchi N, Ikeda Y
    • Journal Title

      Methods Mol Biol

      Volume: 1022 Pages: 335-348

    • DOI

      10.1007/978-1-62703-465-4_25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
  • [Journal Article] An Assay forα1,6-Fucosyltransferase (FUT8) Activity based on the HPLC Separation of a Reaction Product with Fluorescence Detection2013

    • Author(s)
      Ihara H, Tsukamoto H, Taniguchi N, Ikeda Y
    • Journal Title

      Methods Mol Biol

      Volume: 1022 Pages: 335-48

    • DOI

      10.1007/978-1-62703-465-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Journal Article] A Delicate Balance–CD73 generated adenosine limits the severity of graft vs. host disease, but also constrains the allogeneic graft vs. tumor effect2013

    • Author(s)
      Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R
    • Journal Title

      OncoImmunology

      Volume: 2(1) Pages: 22107-22107

    • DOI

      10.4161/onci.22107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2012

    • Author(s)
      Tsukamoto H, Fukudome K, Takao S, .
    • Journal Title

      Int Immunol

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-21590538
  • [Journal Article] Measurement of peroxiredoxin-4 in rat tissues and implication of its serum level as a potential marker for hepatic disease.2012

    • Author(s)
      Ritsu Ito
    • Journal Title

      Mol. Med. Report

      Volume: 6 Pages: 379-384

    • DOI

      10.3892/mmr.2012.935

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590262, KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
  • [Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2012

    • Author(s)
      Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ihara H, Ikeda Y, Kimoto M
    • Journal Title

      Int Immunol

      Volume: 24 Pages: 495-506

    • DOI

      10.1093/intimm/dxs053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23550099, KAKENHI-PROJECT-24790112
  • [Journal Article] Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease2012

    • Author(s)
      Tsukamoto H, Chernogorova P, Ayata K, Gerlach UV, Rughani A, Ritchey JW, Ganesan J, Follo M, Zeiser R, Thompson LF, Idzko M
    • Journal Title

      Blood

      Volume: 119(19) Pages: 4554-4564

    • DOI

      10.1182/blood-2011-09-375899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Journal Article] Multiple potential regulatory sites of TLR4 activation induced by LPS as revealed by novel inhibitory human TLR4 mAbs2012

    • Author(s)
      Tsukamoto H
    • Journal Title

      Int Immunol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590538
  • [Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.2010

    • Author(s)
      Tsukamoto H
    • Journal Title

      Int Immunol.

      Volume: 22(4) Pages: 271-280

    • NAID

      10027392279

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590538
  • [Journal Article] Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010

    • Author(s)
      Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
    • Journal Title

      Int Immunol

      Volume: 22(4) Pages: 271-80

    • NAID

      10027392279

    • Data Source
      KAKENHI-PROJECT-21590538
  • [Journal Article] TEX101, a Germ Cell-Marker Glycoprotein, is Associated with Lymphocyte Antigen 6 Complex Locusk within the Mouse Testis Biochem2008

    • Author(s)
      Hiroshi Yoshitake, Hiroki Tsukamoto, Mayuko Maruyama-Fukushima, Kenji Takamori, Hideoki Ogawa, Yoshihiko Araki
    • Journal Title

      Biophys. Res. Commun 372(2)

      Pages: 277-282

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Journal Article] Genomic organization and structure of the 5'-flanking region of the TEX101 gene: Alternative promoter usage and splicinggenerate transcript variants with distinct 5'-untranslated region.2007

    • Author(s)
      Tsukamoto H
    • Journal Title

      Mol Reprod Dev. 74(2)

      Pages: 154-162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Journal Article] Genomic organization and structure of the 5-flanking region of the TEX101 gene : Alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region.2007

    • Author(s)
      Tsukamoto H
    • Journal Title

      Mol Rep rod Dev. 74(2)

      Pages: 154-162

    • Data Source
      KAKENHI-PROJECT-18890140
  • [Journal Article] Preparation and Characterization of Agonistic Monoclonal Antibodies Against Toll-Like Receptor 4-MD-2 Complex2007

    • Author(s)
      Bahrun U, Kimoto M, Tsukamoto H, Tsuneyoshi N, Kohara J, Fukudome K
    • Journal Title

      Hybridoma 26

      Pages: 393-399

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Journal Article] Preparation of recombinant murine tumor necrosis factor-alpha in Escherichia coli : a rapid method to remove tags from fusion proteins by thrombin-cleavage and ion-exchange chromatography2007

    • Author(s)
      Tsukamoto H, Fukudome K, Kohara J, Nakatake H, Kimoto M
    • Journal Title

      Protein Expr Purif 56(1)

      Pages: 138-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Journal Article] Genomic organization and structure of the 5'-flanking region of the TEX101 gene : Alternative promoter usage and splicing generate transcript variants with distinct 5'-untranslated region2007

    • Author(s)
      Tsukamoto H, Takizawa T, Takamori K, Ogawa H, Araki Y
    • Journal Title

      Mol Reprod Dev 74(2)

      Pages: 154-162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Journal Article] Testicular proteins associated with the germ celトmarker, TEX101 : Involvement of cellubrevin in TEX101-trafficking to the cell surface during spermatogenesis.2006

    • Author(s)
      Tsukamoto H
    • Journal Title

      Biochem Biophys Res Commun 345

      Pages: 229-238

    • Data Source
      KAKENHI-PROJECT-18890140
  • [Patent] 炎症治療用医薬組成物2012

    • Inventor(s)
      木本雅夫、塚本宏樹、福留健司、常吉直子
    • Industrial Property Rights Holder
      佐賀大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-06-15
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Patent] 炎症治療用医薬組成物2012

    • Inventor(s)
      木本雅夫、塚本宏樹、福留健司、常吉直子
    • Industrial Property Rights Holder
      佐賀大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-06-15
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] Toll 様受容体4 刺激抗体の肥満細胞抑制作用2020

    • Author(s)
      渡邉悠理香、塚本宏樹、小林洋平、富岡佳久
    • Organizer
      第59回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] ヒトperoxiredoxin 4モノクローナル抗体の作製とエピトープ解析2020

    • Author(s)
      塚本宏樹、紫竹歩、後藤裕徳、小坂井沙緒、富岡佳久、池田義孝
    • Organizer
      第93回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] 安定同位体内標準物質を用いた修飾核酸一斉定量系の構築2020

    • Author(s)
      平本航大、渡辺匠、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-19H03509
  • [Presentation] 安定同位体内標準物質を用いた修飾核酸一斉定量系の構築2020

    • Author(s)
      平本航大、渡辺匠、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会第140年会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] Toll様受容体4刺激抗体によるアレルギー性接触皮膚炎抑制効果2019

    • Author(s)
      紫竹歩、塚本宏樹、渡邊康一、野地智法、麻生久、富岡佳久
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] CKD評価法に用いる蛍光標識フェニルサルフェートの合成2019

    • Author(s)
      中村隆太郎、松本洋太郎、塚本 宏樹、金光祥臣、富岡佳久
    • Organizer
      第58回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-19H03509
  • [Presentation] Peroxiredoxin 4は臨床的放射線耐性口腔扁平上皮癌細胞の耐性能に寄与する2019

    • Author(s)
      後藤裕徳、金光祥臣、桑原義和、福本学、塚本宏樹、富岡佳久
    • Organizer
      第58回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] CKD評価法に用いる蛍光標識フェニルサルフェートの合成2019

    • Author(s)
      中村隆太郎、松本洋太郎、塚本 宏樹、金光祥臣、富岡佳久
    • Organizer
      第58回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] Peroxiredoxin 4は臨床的放射線耐性口腔扁平上皮癌細胞の耐性能に寄与する2019

    • Author(s)
      後藤裕徳、金光祥臣、桑原義和、福本学、塚本宏樹、富岡佳久
    • Organizer
      第58回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-19H03509
  • [Presentation] 修飾核酸の高精度一斉定量系の構築2018

    • Author(s)
      平本航大、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      第57回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] Toll 様受容体4(TLR4)刺激抗体によるがん免疫療法の開発2018

    • Author(s)
      塚本宏樹、久保田佳苗、富岡佳久
    • Organizer
      日本薬学会 医療薬学フォーラム2018
    • Data Source
      KAKENHI-PROJECT-16H04704
  • [Presentation] Toll 様受容体4 による樹状細胞の抗原取込とT 細胞抗原特異的免疫応答の抑制2018

    • Author(s)
      髙梨理紗子、小坂井沙緒、塚本宏樹、富岡佳久
    • Organizer
      第57回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] 多層オミクス手法による放射線耐性化関連分子の探索2018

    • Author(s)
      富岡佳久、金光祥臣、松本洋太郎、桑原 義和、福本 学、塚本宏樹
    • Organizer
      第3回 治療耐性がん細胞研究協議会セミナー
    • Data Source
      KAKENHI-PROJECT-16K20909
  • [Presentation] Toll様受容体4刺激抗体による抗腫瘍T細胞誘導を介したがん免疫療法2018

    • Author(s)
      塚本宏樹、久保田佳苗、富岡佳久
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16H04704
  • [Presentation] Toll様受容体4刺激抗体による抗腫瘍T細胞誘導を介したがん免疫療法2018

    • Author(s)
      塚本宏樹、久保田佳苗、富岡佳久
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-18K06651
  • [Presentation] 修飾核酸の高精度一斉定量系の構築2018

    • Author(s)
      平本航大、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会 第57回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-16H04704
  • [Presentation] 異なるシグナル誘導活性を持つToll様受容体4刺激抗体による抗原特異的抗体産生抑制効果2017

    • Author(s)
      小林洋平、小坂井沙緖、久保田佳苗、武内偲乃、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター・東北大学)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] ヒトToll様受容体4活性化に必要なleucine-rich repeat 13は抑制抗体によって認識される2017

    • Author(s)
      山形由貴、大久保美咲、鵜飼一歩、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター・東北大学)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] LC-MSを用いた細胞内サイクリックADPリボース高感度定量法の構築2017

    • Author(s)
      齋藤一樹、金光祥臣、田中晃佑、鈴木千登世、阿部高明、塚本宏樹、松本洋太郎、富岡佳久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター・東北大学)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] ミックスドモード ODS カラムを用いた LC-MS/MS による尿毒症物質一斉定量系の構築2017

    • Author(s)
      金光祥臣、淺地圭、松本洋太郎、塚本宏樹、三枝大輔、阿部高明、富岡佳久
    • Organizer
      第56回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-16K20909
  • [Presentation] サイクリックADP リボース安定同位体の合成2017

    • Author(s)
      齋藤一樹、田中晃佑、鈴木千登世、阿部高明、金光祥臣、塚本宏樹、松本洋太郎、富岡佳久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター・東北大学)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] 不活性型二量体構造の誘導を介した抑制型ヒトToll様受容体4抗体の新規作用機序2017

    • Author(s)
      山形由貴、鵜飼一歩、金光祥臣、小林洋平、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター・東北大学)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] LPS-binding proteinはToll様受容体4の二量体化・内在化を介してTRIF依存的IKKε/TBK1/IRF3経路を活性化する2017

    • Author(s)
      久保田佳苗、武内偲乃、鵜飼一歩、小坂井沙緒、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター・東北大学)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] Toll様受容体4シグナルによるGr1+CD11b+細胞誘導を介した抗原特異的抗体産生抑制機序2017

    • Author(s)
      小坂井沙緒、小林洋平、金光祥臣、松本洋太郎、塚本宏樹、富岡佳久
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台市(仙台国際センター・東北大学)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] LC-HDMS および IMS を用いたヒト肝癌組織メタボロミクスによる新規バイオマーカーの同定2017

    • Author(s)
      永井滉士、三枝大輔、山崎貴広、金光祥臣、塚本宏樹、池田均、矢冨裕、松本洋太郎 、富岡佳久
    • Organizer
      第56回日本薬学会東北支部大会
    • Data Source
      KAKENHI-PROJECT-16K20909
  • [Presentation] LC-MSを用いた高感度サイクリックADPリボース定量法の構築2016

    • Author(s)
      齋藤一樹、金光祥臣、松本洋太郎、塚本宏樹、鈴木千登世、阿部高明、富岡佳久
    • Organizer
      第55回日本薬学会東北支部大会
    • Place of Presentation
      郡山市(奥羽大学)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] イナビルによるアナフィラキシー症例報告と添加乳糖に夾雑するアレルゲン乳タンパク質の同定2016

    • Author(s)
      金光祥臣、森川みき、塚本宏樹、松本洋太郎、森川昭正、富岡佳久
    • Organizer
      第26回日本医療薬学会年会
    • Place of Presentation
      京都市(国立京都国際会館・グランドプリンスホテル京都)
    • Year and Date
      2016-09-17
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] LPS-binding proteinはリポ多糖によるToll様受容体4の内在化を誘導する2016

    • Author(s)
      武内偲乃、久保田佳苗、小坂井沙緒、塚本宏樹、富岡佳久
    • Organizer
      第55回日本薬学会東北支部大会
    • Place of Presentation
      郡山市(奥羽大学)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] Simultaneous quantitative analysis of modified nucleosides by liquid chromatography-tandem mass spectrometry2015

    • Author(s)
      Jinno D, Saitoh K, Nankumo S, Kanemitsu Y, Tsukamoto H, Matsumoto Y, Mishima E, Suzuki C, Abe T, Tomioka Y
    • Organizer
      Pharmaceutical Science Symposium 2015 in Sendai
    • Place of Presentation
      仙台(東北大学片平キャンパス))
    • Year and Date
      2015-11-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] LC/MS/MSによる修飾核酸一斉定量法の構築と応用2015

    • Author(s)
      陣野大輔、齋藤一樹、南雲信之介、金光祥臣、塚本宏樹、松本洋太郎、三島英換、鈴木千登世、阿部高明、富岡佳久
    • Organizer
      第54回日本薬学会東北支部大会
    • Place of Presentation
      岩手(岩手医科大学矢巾キャンパス)
    • Year and Date
      2015-09-26
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] リコカルコンAのCOX-1活性抑制メカニズムの解明2014

    • Author(s)
      菅原大貴、田代匠、三枝大輔、塚本宏樹、奥田亜沙、小原祐太郎、鈴木直人、富岡佳久
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] 抗1-methyladenosine抗体反応性分子の同定を目的としたtRNA分子種の解析法に関する研究2014

    • Author(s)
      津久井佑梨、陣野大輔、三島英換、鈴木直人、塚本宏樹、三枝大輔、伊藤邦彦、阿部高明、富岡佳久
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] シースレスインターフェイスを用いたCE-MSによる低分子化合物分析法の検討2014

    • Author(s)
      陣野大輔、齋藤一樹、由利謙典、武川力永、塚本宏樹、鈴木直人、阿部高明、富岡佳久
    • Organizer
      第53回日本薬学会東北支部大会
    • Place of Presentation
      いわき
    • Year and Date
      2014-10-05
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] 新規腎障害マーカーとしての1-メチルアデノシンの検討2013

    • Author(s)
      陣野大輔、鈴木直人、津久井佑梨、三枝大輔、三島英換、鈴木千登世、塚本宏樹、阿部高明、富岡佳久
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-10-20
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] MD-2-dependent and lipopolysaccharide-induced conformation change-sensitive monoclonal antibodies detect extracellular association of human toll-like receptor 4 with soluble MD-2 on cell surface2013

    • Author(s)
      Tsukamoto H, Ukai I, Kimoto M
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] LC/ESI‐MSを用いた血清胸腺因子(FTS)定量法の開発2013

    • Author(s)
      中曽根正皓、鈴木直人、金光祥臣、塚本宏樹、富岡佳久
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2013-10-20
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] MD-2-dependent and lipopolysaccharide-induced conformation change-sensitive monoclonal antibodies detect extracellular association of human toll-like receptor 4 with soluble MD-2 on cell surface2013

    • Author(s)
      Tsukamoto H, Ukai I, Kimoto M
    • Organizer
      第42回日本免疫学会総会・学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] Enzymatic synthesis of di-fucosylated chitooligosaccharide by human and rhizobia α1,6-fucosyltransferases2012

    • Author(s)
      Ihara H, Hanashima S, Tsukamoto H, Yamaguchi Y, Taniguchi N, Ikeda Y
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] Enzymatic synthesis of di-fucosylated chitooligosaccharide by human and rhizobiaα1,6-fucosyltransferases2012

    • Author(s)
      Ihara H, Hanashima S, Tsukamoto H, Yamaguchi Y, Taniguchi N, Ikeda Y
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] Reduced surface expression of TLR4 by a V254I point mutation may account for the low LPS responder phenotype of BALB/c B cells2012

    • Author(s)
      Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] Inhibition of antibody production in vivo by pre-injection of agonistic anti-TLR4/MD-2 monoclonal antibody before antigen priming is caused not by impairment in antigen presentation but by defective B cell priming2012

    • Author(s)
      Rachmawati NM, Fukudome K, Tsuneyoshi N, Bahrun U, Tsukamoto H, Ohta S, Kimoto M
    • Organizer
      第41回日本免疫学会総会・学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] Lipopolysaccharide-bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells2010

    • Author(s)
      Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M.
    • Organizer
      第14回国際免疫学会議
    • Year and Date
      2010-08-27
    • Data Source
      KAKENHI-PROJECT-21590538
  • [Presentation] Lipopolysaccharide-bindingprotein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells.2010

    • Author(s)
      Tsukamoto H
    • Organizer
      第14回国際免疫学会議
    • Place of Presentation
      神戸市
    • Year and Date
      2010-08-27
    • Data Source
      KAKENHI-PROJECT-21590538
  • [Presentation] Anti- human TLR4 monoclonal antibody which specifically prevents the LPS responses independently of Fc receptors2008

    • Author(s)
      Tsukamoto H
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Presentation] 機能抑制型ヒトTLR4抗体Anti-human TLR4 monoclonal antibody which specifically prevents the LPS responses independently of Fc receptors2008

    • Author(s)
      Tsukamoto H, Kimoto M, Tsuneyoshi N, Fukudome K
    • Organizer
      第38回日本免疫学会総会
    • Place of Presentation
      日本免疫学会会誌38:169
    • Year and Date
      2008-12-02
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Presentation] Oligomerization-independent TLR4-signaling in CD14-negative cells2007

    • Author(s)
      Tsukamoto H, Kohara J, Tsuneyoshi N, Kimoto M, Fukudome K
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      日本免疫学会会誌37:163
    • Year and Date
      2007-11-21
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Presentation] Oligomerization-independent TLR4-signaling in CD14-negative cells.2007

    • Author(s)
      Tsukamoto H
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Presentation] Adjuvant effects of agonistic anti-TLR4 monoclonal antibody in antibody induction2007

    • Author(s)
      Fukudome K, Kohara J, Tsukamoto H,Tsuneyoshi N, Kimoto M
    • Organizer
      第37回日本免疫学会総会
    • Place of Presentation
      日本免疫学会会誌37:227
    • Year and Date
      2007-11-22
    • Data Source
      KAKENHI-PROJECT-19790093
  • [Presentation] 機能性Toll様受容体4抗体による敗血症治療と病態解析への応用(シンポジスト)

    • Author(s)
      塚本宏樹、富岡佳久
    • Organizer
      第16回応用薬理シンポジウム
    • Place of Presentation
      松島
    • Year and Date
      2014-12-04 – 2014-12-05
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] Graft‐versus‐host diseaseにおけるCD73と細胞外アデノシンの役割

    • Author(s)
      塚本宏樹
    • Organizer
      第12回医療薬学若手研究者セミナーシンポジスト
    • Place of Presentation
      東北大学(仙台)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] 新規腎障害マーカーとしての1-メチルアデノシンの検討

    • Author(s)
      陣野大輔、鈴木直人、津久井佑梨、三枝大輔、三島英換、鈴木千登世、塚本宏樹、阿部高明、富岡佳久
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      東北大学(仙台)
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] 新規ヒトTLR4モノクローナル抑制抗体のエピトープ解析

    • Author(s)
      鵜飼一歩、塚本宏樹、山形由貴、鈴木直人、富岡佳久
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] CD14のLPS結合能とTLR4内在化の機能連関

    • Author(s)
      武内偲乃、塚本宏樹、鵜飼一歩、山形由貴、久保田佳苗、小坂井沙緒、富岡佳久
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] LC/ESI‐MS を用いた血清胸腺因子(FTS)定量法の開発

    • Author(s)
      中曽根正皓、鈴木直人、金光祥臣、塚本宏樹、富岡佳久
    • Organizer
      第52回日本薬学会東北支部大会
    • Place of Presentation
      東北大学(仙台)
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] 機能抑制型抗ヒトTLR4モノクローナル抗体は不活性型TLR4二量体構造を誘導する

    • Author(s)
      山形由貴、塚本宏樹、鵜飼一歩、鈴木直人、富岡佳久
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Data Source
      KAKENHI-PROJECT-26460058
  • [Presentation] 移植片対宿主病と移植片対腫瘍効果における細胞外アデノシン産生系の機能解析とその薬学的制御に関する研究

    • Author(s)
      塚本宏樹
    • Organizer
      東北薬学セミナー奨励賞受賞講演
    • Place of Presentation
      東北薬科大学(仙台)
    • Invited
    • Data Source
      KAKENHI-PROJECT-24790112
  • [Presentation] A validated quantitative LC-MS/MS method using isotopic MRM transitions to evaluate global ratios of modified cytosines

    • Author(s)
      Tsuji M, Matsunaga H, Jinno D, Tsukamoto H, Suzuki N, Tomioka Y
    • Organizer
      20th International Mass Spectrometry Conference (IMSC 2014)
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2014-08-24 – 2014-08-29
    • Data Source
      KAKENHI-PROJECT-26460058
  • 1.  TOMIOKA Yoshihisa (00282062)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 38 results
  • 2.  MATSUMOTO Yotato (90420041)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 10 results
  • 3.  KIMOTO Masao (40153225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  FUKUDOME Kenji (50284625)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 5.  Kanemitsu Yoshitomi (30752943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 6.  FUKUMOTO Manabu (60156809)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  KUWAHARA Yoshikazu (00392225)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  秋山 泰利 (70635557)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  NUMASAKI Muneo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KUMADA Kanako
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  OHRUI Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  IHARA Hideyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 13.  YAMAGUCHI Tamio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  WADA Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  FUKUI Ryutaro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  渡辺 康一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  麻生 久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  野地 智法
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  太田 昭一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 20.  西岡 安彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 21.  鄭 文玉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 6 results
  • 22.  阿部 高明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 23.  山口 浩明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 24.  長尾 静子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  三島 英換
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 26.  鈴木 健弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  福田 真嗣
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 28.  和田 淳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  大和田 祐二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  高森 建二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  加茂 敦子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  荒木 慶彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  吉武 洋
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  高木 清司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 35.  小柴 生造
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  三枝 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  山崎 聡
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  斉藤 伸一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  三宅 健介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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