NAGAI Tadashi 永井正

Researcher Number	40237483
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2010 – 2014: 自治医科大学, 医学部, 准教授 2004 – 2005: Jichi Medical School, Faculty of Medicine, Associate Professor, 医学部, 助教授 2002 – 2003: Jichi Medical School, Faculty of Medicine, Assistant Professor, 医学部, 講師 2001: 自治医科大学, 医学部, 助手 1998: 東北大, 医学部, 助手 1997: Tohoku University, School of Medicine, Assistant Professor, 医学部, 助手
Review Section/Research Field	Principal Investigator Hematology / Hematology / General medical chemistry Except Principal Investigator Hematology / Functional biochemistry / General medical chemistry
Keywords	Principal Investigator K562 / R115777 / imatinib / β-globin / RR / Tipifarnib / Drug resistance / KU812 / SR / KCL22 … More / RAS / 薬剤耐性 / 慢性骨髄性白血病 / HL60 / Farnesyltransferase inhibitor / Heme / Imatinib / Chronic myeloid leukemia / ABL / BCR / drug resistance / CML / farnesyltransferase inhibitor / heme / K532 / fanesyltransferase inhibitor / Chronic Myelogeneous leukemia / γ-GCS / Nrf2 / ascorbic acid / STI571 / Farnesyltransferase阻害剤 / 5-aza-2-deoxycytidine / Uridine-cytidine kinase / Azacitidine / romidepsin / THP-1 / uridine-cytidine kinase / azacitidine / U266 / 多発性骨髄腫 / NF-AT / 32D / NFAT / calcineurin / 急性骨髄性白血病 / RCAN1 / 補助転写活性化因子 / p45 / NF-E2 / 転写因子 … More Except Principal Investigator imatinib / RhoA / ABL / BCR / 薬剤耐性 / 慢性骨髄性白血病 / all-trans retinoic acid / autocrine / drug-sensitivity / apoptosis / APL / TRAIL / FOXO3a / FKHRL1 / Bach2 / Bach1 / MafK / GATA-1 / NF-E2 / 5-アミノレブリン酸合成酵素 / ヘム / glutatione / Heme / SR / KCL22 / Drug resistance / CML / UCN-01 / Faenesyltransferase阻害薬 / Nrf2 / グルタチオン / KCL22SR / トランスジェニックマウス / siRNA / 造血 / アポトーシス / DNAマイクロアレイ / coproporphyrinogen oxidase / 5-aminolevulinate synthase / heme regulatory motif / M-TAT細胞 / メロンボポエチン / Bach因子 / p45 / コプロポルフィリノーゲンオキシダーゼ / ヘム調節モチーフ / 癌遺伝子 / レトロウイルス / RCAN1 / RELB / レトロウイルスライブラリー / T細胞性リンパ腫 / 組織特異性 / ハーダー氏腺 / ハム / 神経細胞 / 胎盤-胎児系 / ヘムオキシゲナーゼ / 造血細胞 / エンハンサー / プロモーター / GATA-2因子 / 転写因子 Less

Azacitidine耐性機序の解明に基づく新たな急性白血病治療戦略の確立Principal Investigator
- Principal Investigator
  
  永井正
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Clarification of RCAN1-mediated deregulation of cellular functionsin leukemia cellsPrincipal Investigator
- Principal Investigator
  
  NAGAI Tadashi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Identification of oncogenes in T cell lymphoma by retrovirus expression screening
- Principal Investigator
  
  FUJIWARA Shinichiro
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical University
Novel mechanisms of drug resistance in leukemia and the new molecular target therapeutic strategies.
- Principal Investigator
  
  OHMINE Ken
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  JICHI MEDICAL SCHOOL
The development of targeted therapies using FKHRL1 for the treatment of leukemia
- Principal Investigator
  
  KOMATSU Norio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Yamanashi
  Jichi Medical University
Analysis of the mechanisms of drug resistance in leukemia cellsPrincipal Investigator
- Principal Investigator
  
  NAGAI Tadashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
Investigations of mechanisms of drug-resistance in leukemia cellsPrincipal Investigator
- Principal Investigator
  
  NAGAI Tadashi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Jichi Medical School
白血病細胞における転写因子GATA-2発現の役割とインターフェロンの効果
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
血球系転写因子NF−E2の活性調節機構の解析Principal Investigator
- Principal Investigator
  
  永井正
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
生命の適応戦略:ヘムの機能の考案
- Principal Investigator
  
  藤田博美
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Hokkaido University
  Tohoku University
Regulation of erythroid differentiation by trnscription factors and heme
- Principal Investigator
  
  HAYASHI Norio
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tohoku University

All 2014 2013 2012 2011 2010 2009 2005 2003 Other

All Journal Article Presentation

[Journal Article] Romidepsin overcomes cell adhesion-mediated drug resistance in multiple myeloma cells.2014
- Author(s)
  Sripayap P, Nagai T, Hatano K, Kikuchi J, Furukawa Y, Ozawa K
- Journal Title
  
  Acta Haematologica
  
  Volume: 132 Issue: 1 Pages: 1-4
- DOI
  10.1159/000357213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461435, KAKENHI-PROJECT-26461430
[Journal Article] Leukemia cells directly phagocytose blood cells in AML-associated hemophagocytic lymphohistiocytosis: A case report and review of the literature.2014
- Author(s)
  Hatano K, Nagai T, Matsuyama T, Sakaguchi , Fujiwara S.I, Oh I, Muroi K, and Ozawa K.
- Journal Title
  
  Acta Haematol.
  
  Volume: 133 Issue: 1 Pages: 98-100
- DOI
  10.1159/000360840
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25461435, KAKENHI-PROJECT-25461459
[Journal Article] Cytokine adsorption therapy for Hodgkin lymphoma-associated haemophagocytic lymphohistiocytosis.2014
- Author(s)
  Tatara R, Sato M, Fujiwara S, Oh I, Muroi K, Ozawa K, Nagai T.
- Journal Title
  
  Internal Med
  
  Volume: 53 Pages: 2365-2368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461435
[Journal Article] Mechanisms of resistance to azacitidine in human leukemia cell lines.2014
- Author(s)
  Sripayap P, Nagai T, Uesawa M, Kobayashi H, Tsukahara T, Ohmine K, Muroi K, Ozawa K.
- Journal Title
  
  Exp Hematol.
  
  Volume: 42 Issue: 4 Pages: 294-306
- DOI
  10.1016/j.exphem.2013.12.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390247, KAKENHI-PROJECT-25461435, KAKENHI-PROJECT-26430168
[Journal Article] Development of psoriasis in a patient with chronic myelogenous leukemia during nilotinib treatment.2013
- Author(s)
  Nagai T, Karakawa M, Komine M, Muroi K, Ohtsuki M, Ozawa K
- Journal Title
  
  Eur J Haematol
  
  Volume: 91 Issue: 3 Pages: 270-272
- DOI
  10.1111/ejh.12153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461435
[Journal Article] Combined azacitidine and romidepsin enhances cytotoxicity in azacitidine-sensitive but not in azacitidine-resistant multiple myeloma cell lines.2013
- Author(s)
  Sripayap P, Nagai T, Ozawa K
- Journal Title
  
  Jichi Med Univ J
  
  Volume: 36 Pages: 13-21
- NAID
  120006408371
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461435
[Journal Article] Sepsis and Meningoencephalitis Caused by <i>Bacillus cereus</i> in a Patient with Myelodysplastic Syndrome2013
- Author(s)
  Tatara R, Nagai T, Suzuki M, Oh I, Fujiwara S, Norizuki M, Muroi K, Ozawa K
- Journal Title
  
  Intern. Med.
  
  Volume: 52 Issue: 17 Pages: 1987-1990
- DOI
  10.2169/internalmedicine.52.0529
- NAID
  130003365783
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461435
[Journal Article] Prediction of progression fromrefractory cytopenia with unilineagedysplasia by analysis of bone marrow blastcell composition.2012
- Author(s)
  Oka, S., Nagai, T., Hanafusa, T.
- Journal Title
  
  J Clin. Exp. Hematop.
  
  Volume: 52 Pages: 63-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Alteration of chromosome 13 abnormalities after therapeutic heamatopoiesis recovery in myelodysplastic syndrome.2012
- Author(s)
  Nagai, T.
- Journal Title
  
  Open J Hematol.
  
  Volume: 3 Pages: 3-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Rituximab-induced interstitial pneumonia dueto CD8-positive T-cell infiltration2012
- Author(s)
  Sato, K., Nagai, T., Izumi, T., Ohmine, K.,Ozaki, K., Muroi, K., and Ozawa, K.
- Journal Title
  
  ActaHaematologica
  
  Volume: 128 Issue: 2 Pages: 107-109
- DOI
  10.1159/000338259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Rituximab plus 70%cyclophosphamide, doxorubicin, vincristineand prednisone for Japanese patients withdiffuse large B-cell lymphoma aged 70 yearsand older.2012
- Author(s)
  Meguro, A., Nagai, T., Ozawa, K.
- Journal Title
  
  Leuk Lymphoma.
  
  Volume: 53 Pages: 43-49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Alteration of chromosome 13 abnormalitiesafter therapeutic heamatopoiesis recovery inmyelodysplastic syndrome2012
- Author(s)
  Nagai, T., Suzuki, T., Komatsu, N.,Hosokawa, K., Nakao, S., and Ozawa, K.
- Journal Title
  
  Open J Hematol.
  
  Volume: 3 Issue: 1 Pages: 3-7
- DOI
  10.13055/ojhmt_3_1_7.121227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Autologous Hematopoietic Recovery with Aberrant Antigen Expression after Allogeneic Bone Marrow Transplantation2012
- Author(s)
  Kobayashi, H., Nagai, T., Muroi, K.
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 52 Issue: 1 Pages: 81-83
- DOI
  10.3960/jslrt.52.81
- NAID
  10030615702
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048, KAKENHI-PROJECT-23590686
[Journal Article] Vincristine potentiates the anti-proliferativeeffect of an aurora kinase inhibitor, VE-465,in myeloid leukemia cells.2011
- Author(s)
  Yoshida, K., Nagai, T., Ohmine, K., Uesawa,M., Sripayap, P., Ishida, Y., and Ozawa, K.
- Journal Title
  
  Biochem.Pharmcol.
  
  Volume: 82 Pages: 1884-1890
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Reciprocal upregulationof Notch signaling molecules inhematopoietic progenitor and mesenchymalstromal cells.2011
- Author(s)
  Kikuchi, Y., Kume, A., Urabe, M.,Mizukami, H., Suzuki, T., Ozaki, K., Nagai,T., and Ozawa, K.
- Journal Title
  
  J Stem Cells Regenerative Med
  
  Volume: 7 Pages: 61-68
- URL
  http://www.pubstemcell.com/monthly/007020300010.htm
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Incidental carcinomasdetected by PET/CT scans in patients withmalignant lymphoma.2010
- Author(s)
  Sato, K., Ozaki, K., Matsuyama, T., Ohmine,K., Suzuki, T., Mori, M., Nagai, T., Muroi,K., and Ozawa, K.:
- Journal Title
  
  Int J Hematol
  
  Volume: 92 Issue: 4 Pages: 647-650
- DOI
  10.1007/s12185-010-0702-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Combination of tipifarnib and rapamycinsynergistically inhibits the growth ofleukemia cells and overcomes resistance totipifarnib via alteration of cellular signalingpathways.2010
- Author(s)
  Nagai, T., Ohmine, K., Fujiwara, S., Uesawa,M., Sakurai, C., and Ozawa, K.
- Journal Title
  
  Leukemia Res.
  
  Volume: 34 Pages: 1057-1063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Imatinib for Newly DiagnosedChronic-Phase Chronic Myeloid Leukemia:Results of a Prospective Study in Japan2010
- Author(s)
  Nagai, T., Takeuchi, J., Usui, N.
- Journal Title
  
  Int Jhematol
  
  Volume: 92 Issue: 1 Pages: 111-117
- DOI
  10.1007/s12185-010-0621-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Imatinib for Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia : Results of a Prospective Study in Japan.2010
- Author(s)
  Nagai, T.
- Journal Title
  
  Int J Hematol.
  
  Volume: VOL.92 Pages: 111-117
- NAID
  10026512176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] AA amyloidosis associated withmacroglobulinemia2010
- Author(s)
  Tatara, R., Nagai, T., Kobayashi, H., Hatano,K., Suzuki, T., Muroi, K., and Ozawa, K
- Journal Title
  
  (Letter) Int J Hematol
  
  Volume: 92 Issue: 4 Pages: 675-677
- DOI
  10.1007/s12185-010-0700-z
- NAID
  10027674199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048, KAKENHI-PROJECT-22790918
[Journal Article] Combination of tipifarnib and rapamycin synergistically inhibits the growth of leukemia cells and overcomes resistance to tipifarnib via alteration of cellular signaling pathways.2010
- Author(s)
  Nagai, T.
- Journal Title
  
  Leukemia Res.
  
  Volume: VOL.34 Pages: 1057-1063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591048
[Journal Article] Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion.2005
- Author(s)
  Nagai, T.
- Journal Title
  
  Internal Medicine 44・10
  
  Pages: 1090-1092
- NAID
  130000085276
- Data Source
  KAKENHI-PROJECT-16590959
[Journal Article] Oxidative stress is involved in hydroxyurea-induced erythroid differentiation.2003
- Author(s)
  Nagai, T
- Journal Title
  
  Br J Haematol 121(4)
  
  Pages: 657-661
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390306
[Journal Article] Oxidative stress is involved in hydroxyurea-induced erythroid differentiation.2003
- Author(s)
  Nagai, T
- Journal Title
  
  Br J Haematol 121・4
  
  Pages: 657-661
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390306
[Journal Article] Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion.
- Author(s)
  Nagai, T.
- Journal Title
  
  Internal Medicine (In press)
- NAID
  130000085276
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591020
[Journal Article] Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion.
- Author(s)
  Nagai, T.
- Journal Title
  
  Internal Medicine (In press)
- NAID
  130000085276
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591020
[Presentation] Crucial role of RCAN1 in leukemia progression.2010
- Author(s)
  Shin-ichiro Fujiwara, Tadashi Nagai, Satoru Kikuchi, Mitsuyo Uesawa, Chihiro Sakurai, Ken Ohmine, Jiro Kikuchi, Yusuke Furukawa, Keiya Ozawa.
- Organizer
  69^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Osaka
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21790921
[Presentation] Ectopic Expression and Role of RCAN1 in Myeloid Leukemia Cells.2009
- Author(s)
  Shin-ichiro Fujiwara, Tadashi Nagai, Satoru Kikuchi, Mitsuyo Uesawa, Chihiro Sakurai, Ken Ohmine, Jiro Kikuchi, Yusuke Furukawa, Keiya Ozawa.
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  New Orleans.
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-21790921

1. OHMINE Ken (90316521)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
2. FUJIWARA Shinichiro (20438667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. HAYASHI Norio (00004606)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 古山和道 (80280874)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MUNAKATA Hiroshi (90111294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KOMATSU Norio (50186798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KIRITO Keita (90306150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 峯岸直子 (40271895)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 五十嵐和彦 (00250738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 藤田博美 (60142931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 森政樹 (00337346)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 内田美栄 (80316520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 外島正樹 (00306151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KIKUCHI Satoru

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. UESAWA Mitsuyo

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. YAMAMOTO Chihiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TSUKAHARA Tomonri

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 小澤敬也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

NAGAI Tadashi 永井 正

Research Projects

Research Products

Co-Researchers

Azacitidine耐性機序の解明に基づく新たな急性白血病治療戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of RCAN1-mediated deregulation of cellular functionsin leukemia cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of oncogenes in T cell lymphoma by retrovirus expression screening

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel mechanisms of drug resistance in leukemia and the new molecular target therapeutic strategies.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of targeted therapies using FKHRL1 for the treatment of leukemia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the mechanisms of drug resistance in leukemia cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigations of mechanisms of drug-resistance in leukemia cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

白血病細胞における転写因子GATA-2発現の役割とインターフェロンの効果

Principal Investigator

Project Period (FY)

Research Category

Research Institution

血球系転写因子NF−E2の活性調節機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生命の適応戦略:ヘムの機能の考案

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of erythroid differentiation by trnscription factors and heme

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Romidepsin overcomes cell adhesion-mediated drug resistance in multiple myeloma cells.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Leukemia cells directly phagocytose blood cells in AML-associated hemophagocytic lymphohistiocytosis: A case report and review of the literature.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytokine adsorption therapy for Hodgkin lymphoma-associated haemophagocytic lymphohistiocytosis.2014

NAGAI Tadashi 永井正