KOKAME KOICHI 小亀浩市

… Alternative Names

KOKAME Koichi 小亀浩市

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Researcher Number	40270730
Other IDs
External Links
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Affiliation (based on the past Project Information) *help	2015 – 2024: 国立研究開発法人国立循環器病研究センター, 研究所, 部長 2012 – 2014: 独立行政法人国立循環器病研究センター, 研究所, 室長 2010 – 2011: 独立行政法人国立循環器病研究センター, 分子病態部, 室長 2009: National Cardiovascular Center Research Institute, 脈管生理部, 室長 2007 – 2009: National Cardiovascular Center Research Institute, 脈管生理部, Senior, staff … More 2008: National Cardiovascular Center Research Institute, 脈管生理部, 室長 2005 – 2006: 国立循環器病センター(研究所), 脈管生理部, 室長 2002 – 2004: NATIONAL CARDIOVASCULAR CENTER, RESEARCH INSITUTE, Laboratory chief, 脈管生理部, 室長 1995 – 2001: 国立循環器病センター研究所, 病因部, 室員 Less
Review Section/Research Field	Principal Investigator Functional biochemistry / Functional biochemistry / Biological Sciences / Basic Section 48040:Medical biochemistry-related Except Principal Investigator Structural biochemistry / Hematology / Structural biochemistry / Basic Section 54010:Hematology and medical oncology-related / Basic Section 55030:Cardiovascular surgery-related / Basic Section 55050:Anesthesiology-related / Neurosurgery / General physiology / Biological Sciences
Keywords	Principal Investigator 小胞体ストレス / Herp / 分子シャペロン / 遺伝子発現 / ストレス応答 / RTP / 血管内皮細胞 / ADAMTS13 / 酵素 / ATF4 … More / ストレス蛋白質 / 血栓症 / ホモシステイン / タンパク質品質管理 / 蛋白質 / ストレス / 小胞体 / 血栓性血小板減少性紫斑病 / フォンビルブランド因子 / 血小板 / 血液 / 品質管理 / 翻訳抑制 / 細胞傷害 / mRNA / 動脈硬化 / 血液凝固 / 心内膜 / 発現多様性 / ノックインマウス / 蛍光タンパク質 / von Willebrand因子 / 低酸素 / 低酸素ストレス / 小胞体関連分解 / 細胞内タンパク質分解 / knockout mouse / thrombotic thrombocytopenic purpura / platelet / blood / enzyme / protease / von Willebrand factor / ノックアウトマウス / プロテアーゼ / プロリン異性化酵素 / 虚血 / BDNF / NDRG4 / NDRG1 / 神経細胞 / 心機能 / 脳機能 / タンパク質 / 動物 / シグナル伝達 / 細胞情報伝達機構 / 蛋白質分解 / ADAMTS-13 / 凝固因子 / 蛋白質品質管理 / 翻訳 / IRES / リゾフォスファチジルコリン / BiP / GRP78 / ディファレンシャルディスプレイ解析 / 高ホモシステイン血症 / Differential Display法 / PTCA後再狭窄 / 細胞外マトリクス / 血管平滑筋細胞 / 細胞培養 … More Except Principal Investigator ADAMTS13 / ホモシステイン / endothelial cells / homocysteine / 血管内皮細胞 / thrombosis / 血栓 / 血栓症 / プロテインS / 凝固制御因子 / 血栓性血小板減少性紫斑病 / kidney / vascular disease / arteriosclerosis / Herp / 静脈血栓塞栓症 / VWF / 血小板 / フォンビルブランド因子 / 静脈血栓症 / 血栓性素因 / クリアランス機構 / Ndrg1 / demyelination / ニューロパチー / ノックアウトマウス / ミエリン / NDRG1 / 小胞体ストレス / phosphorylation / 小胞体 / 腎 / stress protein / 遺伝子解析 / 分子シャペロン / RTP / 動脈硬化 / diabetes / 遺伝子変異 / 結晶構造 / 遺伝子多型 / マウスモデル / 遺伝子 / 脳梗塞 / プロテアーゼ / 血小板凝集 / 血小板血栓 / 血液凝固能 / 心臓外科 / 人工心肺 / ヘパリン / 体外循環 / 血液凝固能検査 / SIGLEC / プラスミノゲン / Siglecファミリー / Siglec / 外傷 / 多発外傷 / 心臓血管手術 / 冷蔵血小板 / 血栓症修飾遺伝子 / 第三世代シーケンサー / 次世代シーケンサー / プロトロンビンバリアント / 登録研究 / modifier / 特発性血栓症 / 脳神経疾患 / 神経科学 / 神経機能回復 / リハビリテーション / 錐体外路 / MRI拡散イメージング / PET / 神経可塑性 / diffusion tensor imaging / 急性期ラクナ梗塞 / 機能回復 / 脳血流量 / 神経微細構造 / 脳PET / 急性ラクナ梗塞 / 変異体 / 静脈血栓症、 / 経口避妊薬 / Ashwell-Morell受容体 / LRP1 / 蛋白質 / クリアランス受容体 / genetic polymorphism / genetic engineered mouse / von Willbrand factor / Thrombocytopenia / Platelet / 血管障害 / 腎傷害 / 微小血管 / メタロプロテアーゼ / 臨床検査法 / 一般住民 / 性差 / 遺伝子改変マウス / 血小板減少症 / Charcot-Marie-Tooth disease / endoplasmic reticulum stress / peripheral neuropathy / 心血管系疾患 / 耐糖脳 / 脳虚血 / 耐糖性 / Charcot-Marie-Tooth病 / 遺伝子欠失マウス / 末梢神経変性 / sensory impairment / mouse model / hereditary motor and sensory neuropathy / Homocysteine / loxP / 神経障害遺伝子 / 遺伝子欠失動物 / 神経軸索 / 脱ミエリン化 / 運動障害 / シュワン細胞 / 運動感覚障害 / 末梢神経傷害 / モデル動物 / 遺伝性運動感覚性ニューロパチー / 酸化LDL / リゾホスファチジルコリン / 分化 / 細胞傷害 / hyperhomocysteinemia / 動脈硬化症 / 高ホモシステイン血症 / 内皮傷害 / 細胞障害 / 内皮障害 / 糸球体 / 尿細管 / リン酸化 / ホモシテイン / molecular chaperone / thromobosis / 先天性欠損症 / 酸化脂質 / リン酸化蛋白質 / クローニング / domain / myocardial infarction / cerebral infarction / hemostasis / coagulation / tissue factor / 蛋白分解酵素 / 血液凝固 / ドメイン / 心筋梗塞 / 糖尿病 / 止血 / 凝固反応 / 組織因子 / 抗凝固機構 / ずり応力 / 酵素動力学 / von Willebrand因子 / エクソサイト / P475S遺伝子多型 / 分子認識及び相互作用 / フォンビルランド因子 / 凝固 / 結晶解析 / 組み換え体 / 立体構造解析 / プロラアーゼ Less

止血タンパク質の発現多様性と止血機能および止血以外の機能に関する基礎研究Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of changes in electrical properties during the blood coagulation process and its use for measurement of blood coagulation status during extracorporeal circulation
- Principal Investigator
  
  松浦功泰
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Tokyo University of Agriculture and Technology
The effectiveness of cold platelet for trauma and great vessel surgery
- Principal Investigator
  
  KODAKA MITSUHARU
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Tokyo Women's Medical University
Genetic background of thrombophilia using third generation DNA sequencing
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cardiovascular Center Research Institute
Regulation of NETs formation by VWF and ADAMTS13 binding to neutrophil Siglecs
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  National Cardiovascular Center Research Institute
Study on endoplasmic reticulum-associated degradation (ERAD) dysfunction causing lethal effects in hypoxiaPrincipal Investigator
- Principal Investigator
  
  Koichi Kokame
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Clearance mechanism of ADAMTS13
- Principal Investigator
  
  Akiyama Masashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  National Cardiovascular Center Research Institute
Studies on thrombotic risk of protein S K196E mutation
- Principal Investigator
  
  Miyata Toshiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Alterations of neurite morphology associated with cerebral blood flow during motor recovery in patients with acute lacuna stroke
- Principal Investigator
  
  Yokota Chiaki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  National Cardiovascular Center Research Institute
Quality control of secretory proteins containing proline residues in the cis formPrincipal Investigator
- Principal Investigator
  
  KOKAME KOICHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Thrombotic phenotypes of two antithrombotic factors, protein S and ADAMTS13
- Principal Investigator
  
  MIYATA TOSHIYUKI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Crystal structure analysis for the pathogenesis of thrombosis
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Molecular and physiological functions of NDRG1 and NDRG4Principal Investigator
- Principal Investigator
  
  KOKAME Koichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
ADAMTS13の基質認識・切断に対する細胞外環境の効果
- Principal Investigator
  
  宮田敏行
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
小胞体関連分解を担うタンパク質複合体の全容解明とその標的タンパク質の同定Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
Thrombosis due to dysfunction of anticoagulant activity and strategy for prevention of thrombosis
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.
- Principal Investigator
  
  AKIYAMA Masashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Research on protein quality control by the endoplasmic reticulum membrane proteinsPrincipal Investigator
- Principal Investigator
  
  KOKAME Koichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Studies on causative gene for thrombotic thrombocytopenic purpura, ADAMTS13
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Physiological and biochemical analysis of VWF-cleaving protease ADAMTS13Principal Investigator
- Principal Investigator
  
  KOKAME Koichi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Herpノックアウトマウスの解析および小胞体ストレス時の翻訳機構に関する研究Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
新しい血液凝固制御因子ADAMTS-13の構造と機能に関する研究Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Functional analysis of endoplasmic reticulum stress-induced genes, NDRG1 and HERPUD1
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  NATIONAL CARDIO VA SCULAR CENTER, RESEARCH INSTITUTE
小胞体ストレス時の翻訳調節機構と小胞体膜タンパク質Herpの機能に関する研究Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Cardiovascular Center Research Institute
小胞体ストレス応答性膜蛋白質Herpの機能および翻訳調節機構の解析Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Analysis of mice lacking for NDRG1 and its homolog.
- Principal Investigator
  
  MIYATA Toshiuyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  NATIONAL CARDIOVASCULAR CENTER RESEARCH INSTITUTE
小胞体ストレス応答性新規蛋白質Herp及びRTPに関する研究Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Cardiovascular Center Research Institute
新規蛋白質Herp及びRTPの小胞体ストレス応答機構解析と機能探索Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Studies on genes involved in endothelial dysfunction involved in thrombosis and atherosclerosis
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
血管内皮細胞の傷害性刺激に伴って発現量が増加する新規遺伝子産物RTPの機能探索Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Studies on new proteins involved in vascular endothelial injury
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
血管内皮細胞のホモシステイン刺激により発現する遺伝子群の解析Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Studies on genes involved in thrombois on endothelial cells
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
血管平滑筋細胞の形質変換誘導機構の分子生物学的解析Principal Investigator
- Principal Investigator
  
  小亀浩市
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  National Cardiovascular Center Research Institute
Studies on the initiation of extrinsic blood coagulation reaction
- Principal Investigator
  
  MIYATA Toshiyuki
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  National Cardiovascular Center Research Institute

[Book] 臨床に直結する血栓止血学2018
- Author(s)
  丸山慶子・小亀浩市（朝倉英策編著）
- Total Pages
  688
- Publisher
  中外医学社
- ISBN
  9784498125797
- Data Source
  KAKENHI-PROJECT-17K07358
[Book] 血栓症ナビゲーター2006
- Author(s)
  小亀浩市
- Total Pages
  317
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Book] 血液疾患 -state of arts Ver.32005
- Author(s)
  小亀浩市
- Total Pages
  798
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Book] 血液疾患-state of arts Ver.32005
- Author(s)
  小亀浩市
- Total Pages
  798
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] Mitral regurgitation is associated with similar loss of von Willebrand factor large multimers, but less anemia as compared to aortic stenosis2024
- Author(s)
  Takiguchi、Miura、Shirai、Soga、Hanyu、Sakaguchi、Soga、Arai、Watanabe、Kimura、Takahama、Yasuda、Nakayoshi、Fukumoto、Yaoita、Shimokawa、Sakatsume、Saiki、Kaikita、Tsujita、Tamura、Doman、Yamashita、Suzuki、Eura Yuka、Kokame Koichi、Hayakawa、Matsumoto、Okubo、Sugawara、Fujimaki、Kawate、Ando、Horiuchi
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 8 Issue: 4 Pages: 102431-102431
- DOI
  10.1016/j.rpth.2024.102431
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K27372
[Journal Article] Congenital thrombotic thrombocytopenic purpura diagnosed in adulthood after repeated thrombocytopenia since neonatal period2024
- Author(s)
  吉野明久、松本雅則、衛藤徹也、谷口修一、栗山拓郎、内海紗江、嶋川卓史、南満理子、林正康、松尾弥生、小亀浩市、中村恵理子
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 65 Issue: 3 Pages: 142-146
- DOI
  10.11406/rinketsu.65.142
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27372
[Journal Article] von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis2024
- Author(s)
  Okubo N, Sugawara S, Fujiwara T, Sakatsume K, Doman T, Yamashita M, Goto K, Tateishi M, Suzuki M, Shirakawa R, Eura Y, Kokame K, Hayakawa M, Matsumoto M, Kawate Y, Miura M, Takiguchi H, Soga Y, Shirai S, Ando K, Arai Y, Nakayoshi T, Fukumoto Y, Takahama H, Yasuda S, Tamura T, Watanabe S, Kimura T, et al
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 8 Issue: 1 Pages: 102284-102284
- DOI
  10.1016/j.rpth.2023.102284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08385, KAKENHI-PROJECT-23K07567, KAKENHI-PROJECT-23K25186, KAKENHI-PROJECT-23K27372
[Journal Article] Three Cases of Unprovoked Venous Thromboembolism with Prothrombin p.Arg596Gln Variant and a Literature Review of Antithrombin Resistance2023
- Author(s)
  Tsuji A, Miyata T, Sekine A, Neki R, Kokame K, Tomita T, et al.
- Journal Title
  
  Intern. Med.
  
  Volume: 62 Issue: 6 Pages: 885-888
- DOI
  10.2169/internalmedicine.9718-22
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2023-03-15
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09530, KAKENHI-PROJECT-19K08875
[Journal Article] 血栓性血小板減少性紫斑病診療ガイド20232023
- Author(s)
  松本雅則、宮川義隆、小亀浩市、上田恭典、和田英夫、日笠聡、八木秀男、小川孔幸、酒井和哉、宮田敏行、森下英理子、藤村吉博
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 64 Issue: 6 Pages: 445-460
- DOI
  10.11406/rinketsu.64.445
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K27372
[Journal Article] P2Y12 Reaction Units and Clinical Outcomes in Acute Large Artery Atherosclerotic Stroke: A Multicenter Prospective Study2023
- Author(s)
  Fukuma K, Yamagami H, Ihara M, Tanaka T, Miyata T, Miyata S, Kokame K, Nishimura K, Nakaoku Y, Yamamoto H, Hayakawa M, Kamiyama K, Enomoto Y, Itabashi R, Furui E, Manabe Y, Ezura M, Todo K, Hashikawa K, Uchiyama S, Toyoda K, Nagatsuka K, and the PRAISE Study Investigators
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 30 Issue: 1 Pages: 39-55
- DOI
  10.5551/jat.63369
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08875, KAKENHI-PROJECT-22K15721
[Journal Article] Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) in Japan 20232023
- Author(s)
  Matsumoto Masanori、Miyakawa Yoshitaka、Kokame Koichi、Ueda Yasunori、Wada Hideo、他
- Journal Title
  
  International Journal of Hematology
  
  Volume: 118 Issue: 5 Pages: 529-546
- DOI
  10.1007/s12185-023-03657-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K07441, KAKENHI-PROJECT-22K08461, KAKENHI-PROJECT-23K25186, KAKENHI-PROJECT-23K27372
[Journal Article] Current prophylactic plasma infusion protocols do not adequately prevent long-term cumulative organ damage in the Japanese congenital thrombotic thrombocytopenic purpura cohort2021
- Author(s)
  Sakai, K. Fujimura, Y. Miyata, T. Isonishi, A. Kokame, K. Matsumoto, M.
- Journal Title
  
  Br J Haematol,
  
  Volume: 194 Issue: 2 Pages: 444-452
- DOI
  10.1111/bjh.17560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08875
[Journal Article] Derlin-3 is required for changes in ERAD complex formation under ER stress2020
- Author(s)
  Eura Y, Miyata T, Kokame K
- Journal Title
  
  Int J Mol Sci
  
  Volume: 21 Issue: 17 Pages: 6146-6146
- DOI
  10.3390/ijms21176146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08875
[Journal Article] Predictive value of protein S-specific activity and ELISA testing in patients with the protein S K196E mutation.2020
- Author(s)
  Miyoshi T, Maruyama K, Oku H, Asahara S, Hanada H, Neki R, Yoshimatsu J, Kokame K, Miyata T.
- Journal Title
  
  Thrombosis Research
  
  Volume: 185 Pages: 1-4
- DOI
  10.1016/j.thromres.2019.10.026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08343, KAKENHI-PROJECT-17J11206, KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-17K16316, KAKENHI-PROJECT-18K09277
[Journal Article] Success and limitations of plasma treatment in pregnant women with congenital thrombotic thrombocytopenic purpura2020
- Author(s)
  Sakai Kazuya、Fujimura Yoshihiro、Nagata Yasuyuki、Higasa Satoshi、Moriyama Masato、Isonishi Ayami、Konno Mutsuko、Kajiwara Michiko、Ogawa Yoshiyuki、Kaburagi Shigehiko、Hara Tomoko、Kokame Koichi、Miyata Toshiyuki、Hatakeyama Kinta、Matsumoto Masanori
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 18 Issue: 11 Pages: 2929-2941
- DOI
  10.1111/jth.15064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08875
[Journal Article] Low-Dose Activated Protein C Suppresses the Development of Cerebral Infarction and Neurological Deficits in Mice2020
- Author(s)
  Yamato Keiko、Nakajo Yukako、Yamamoto-Imoto Hitomi、Kokame Koichi、Miyata Toshiyuki、Takahashi Jun C、Kataoka Hiroharu、Yanamoto Hiroji
- Journal Title
  
  Neurosurgery Open
  
  Volume: 1 Issue: 4 Pages: 1-12
- DOI
  10.1093/neuopn/okaa014
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08875
[Journal Article] Genetic diagnosis of TMA: TTP and aHUS2020
- Author(s)
  Miyata Toshiyuki、Kokame Koichi
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 31 Issue: 1 Pages: 17-27
- DOI
  10.2491/jjsth.31.17
- NAID
  130007801461
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] Cerebral venous sinus thrombosis associated with protein S deficiency during pregnancy: a case report.2020
- Author(s)
  Usui M, Ozawa T, Kim Y, Mashiko T, Matsuzono K, Maruyama K, Kokame K, Usui R, Koide R, Fujimoto S.
- Journal Title
  
  J Obstet Gynaecol
  
  Volume: 40 Issue: 1 Pages: 135-6
- DOI
  10.1080/01443615.2019.1606789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17J11206, KAKENHI-PROJECT-17K07358
[Journal Article] Acquired von Willebrand Syndrome Associated with Cardiovascular Diseases2019
- Author(s)
  Hisanori Horiuchi, Tsuyoshi Doman, Koichi Kokame, Yoshikatsu Saiki, Masanori Matsumoto
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 26 Issue: 4 Pages: 303-314
- DOI
  10.5551/jat.RV17031
- NAID
  130007621871
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2019-04-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] Knock‐in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction2019
- Author(s)
  Akuta Keigo、Kiyomizu Kazunobu、Kashiwagi Hirokazu、Kunishima Shinji、Nishiura Nobuko、Banno Fumiaki、Kokame Koichi、Kato Hisashi、Kanakura Yuzuru、Miyata Toshiyuki、Tomiyama Yoshiaki
- Journal Title
  
  Journal of Thrombosis and Haemostasis
  
  Volume: 18 Issue: 2 Pages: 497-509
- DOI
  10.1111/jth.14678
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-19K08813, KAKENHI-PROJECT-19K08875, KAKENHI-PROJECT-19K11725
[Journal Article] Experience of the use of octreotide for refractory gastrointestinal bleeding in a patient with Jarvik2000 left ventricular assist device2019
- Author(s)
  Nakajima-Doi Seiko、Seguchi O、Shintani Y、Fujita T、Fukushima S、Matsumoto Y、Eura Yuka、Kokame Koichi、Miyata S、Matsuda S、Mochizuki H、Iwasaki K、Kimura Y、Toda K、Kumai Y、Kuroda K、Watanabe T、Yanase M、Kobayashi J、Fukushima Norihide
- Journal Title
  
  Journal of Artificial Organs
  
  Volume: 22 Issue: 4 Pages: 334-337
- DOI
  10.1007/s10047-019-01121-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] ADAMTS13の構造変化と機能発現2019
- Author(s)
  秋山正志、小亀浩市
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 9 Pages: 196-205
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] Patent ductus arteriosus generates neonatal hemolytic jaundice with thrombocytopenia in Upshaw-Schulman syndrome2019
- Author(s)
  Fujimura Yoshihiro、Lammle Bernhard、Tanabe Saori、Sakai Kazuya、Kimura Toshiyuki、Kokame Koichi、Miyata Toshiyuki、Takahashi Yukihiro、Taniguchi Shigeki、Matsumoto Masanori
- Journal Title
  
  Blood Advances
  
  Volume: 3 Issue: 21 Pages: 3191-3195
- DOI
  10.1182/bloodadvances.2019000601
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] The international hereditary thrombotic thrombocytopenic purpura (TTP) registry: Key findings at enrolment until 20172019
- Author(s)
  van Dorland HA, Mansouri Taleghani M, Sakai K, Friedman KD, George JN, Hrachovinova I, Knobl PN, von Krogh AS, Schneppenheim R, Aebi-Huber I, Butikofer L, Largiader CR, Cermakova Z, Kokame K, Miyata T, Yagi H, Terrell DR, Vesely SK, Matsumoto M, Lammle B, Fujimura Y, Kremer Hovinga JA
- Journal Title
  
  Haematologica
  
  Volume: 印刷中 Issue: 10 Pages: 2107-2115
- DOI
  10.3324/haematol.2019.216796
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-16K09834
[Journal Article] ADAMTS13 の構造変化と機能発現2019
- Author(s)
  秋山正志、小亀浩市
- Journal Title
  
  Thrombosis Medicine
  
  Volume: 9(3) Pages: 12-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08829
[Journal Article] Effects of low-dose combined oral contraceptives and protein S K196E mutation on anticoagulation factors: a prospective observational study2019
- Author(s)
  Takekazu Miyoshi, Hisato Oku, Saiko Asahara, Akira Okamoto, Koichi Kokame, Michikazu Nakai, Kunihiro Nishimura, Fumiyuki Otsuka, Aya Higashiyama, Jun Yoshimatsu, Toshiyuki Miyata
- Journal Title
  
  International Journal of Hematology
  
  Volume: 印刷中 Issue: 6 Pages: 641-649
- DOI
  10.1007/s12185-019-02633-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-19K08343, KAKENHI-PROJECT-17K16316
[Journal Article] Novel CFHR2-CFHR1 Hybrid in C3 Glomerulopathy Identified by Genomic Structural Variation Analysis2019
- Author(s)
  Sugawara Y, Kato H, Yoshida Y, Fujisawa M, Kokame K, Miyata T, Akioka Y, Miura K, Hattori M, Nangaku M.
- Journal Title
  
  Kidney Int Rep.
  
  Volume: 4 Issue: 12 Pages: 1759-1762
- DOI
  10.1016/j.ekir.2019.09.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16073, KAKENHI-PROJECT-17K07358
[Journal Article] Upshaw-Schulman syndrome diagnosed during pregnancy complicated by reversible cerebral vasoconstriction syndrome2018
- Author(s)
  Mariko Tsuda, Motoaki Shiratsuchi, Motohiko Ikeda, Masanori Matsumoto, Yoshihiro Fujimura, Koichi Kokame, Takamitsu Matsushima, Yasuhiro Nakashima, Yoshihiro Ogawa
- Journal Title
  
  Transfusion and Apheresis Science
  
  Volume: 57 Issue: 6 Pages: 790-792
- DOI
  10.1016/j.transci.2018.10.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-16K10580
[Journal Article] Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis2018
- Author(s)
  Navarro-Marquez Mario、Torrealba Natalia、Troncoso Rodrigo、V?squez-Trincado Cesar、Rodriguez Marcelo、Morales Pablo E.、Villalobos Elisa、Eura Yuka、Garcia Lorena、Chiong Mario、Klip Amira、Jaimovich Enrique、Kokame Koichi、Lavandero Sergio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1864 Issue: 5 Pages: 1653-1662
- DOI
  10.1016/j.bbadis.2018.02.018
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-15K18510
[Journal Article] Clinical characteristics and genetic backgrounds of Japanese patients with atypical hemolytic uremic syndrome2018
- Author(s)
  Fujisawa Madoka、Kato Hideki、Yoshida Yoko、Usui Tomoko、Takata Munenori、Fujimoto Mika、Wada Hideo、Uchida Yumiko、Kokame Koichi、Matsumoto Masanori、Fujimura Yoshihiro、Miyata Toshiyuki、Nangaku Masaomi
- Journal Title
  
  Clinical and Experimental Nephrology
  
  Volume: 印刷中 Issue: 5 Pages: 1088-1099
- DOI
  10.1007/s10157-018-1549-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-17K16073, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-15K09246
[Journal Article] ADAMTS132018
- Author(s)
  小亀浩市
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 29 Issue: 6 Pages: 586-588
- DOI
  10.2491/jjsth.29.586
- NAID
  130007530558
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] Protein S K196E mutation reduces its cofactor activity for APC but not for TFPI2018
- Author(s)
  Keiko Maruyama, Masashi Akiyama, Toshiyuki Miyata, Koichi Kokame
- Journal Title
  
  Research and Practice in Thrombosis and Haemostasis
  
  Volume: 2 Issue: 4 Pages: 751-756
- DOI
  10.1002/rth2.12152
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-17J11206, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K08515
[Journal Article] 血栓性血小板減少性紫斑病 (TTP)診療ガイド20172017
- Author(s)
  松本雅則、藤村吉博、和田英夫、小亀浩市、宮川義隆、上田恭典、日笠聡、森木隆典、八木秀男、宮田敏行、村田満
- Journal Title
  
  臨床血液
  
  Volume: 58 Pages: 271-281
- NAID
  40021201622
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09834
[Journal Article] ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in MiceHighlights2017
- Author(s)
  Dhanesha Nirav、Doddapattar Prakash、Chorawala Mehul R.、Nayak Manasa K.、Kokame Koichi、Staber Janice M.、Lentz Steven R.、Chauhan Anil K.
- Journal Title
  
  Arteriosclerosis, Thrombosis, and Vascular Biology
  
  Volume: 37 Issue: 7 Pages: 1332-1338
- DOI
  10.1161/atvbaha.117.309539
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] Siblings with congenital thrombotic thrombocytopenic purpura2017
- Author(s)
  舩越康智、岡田雅彦、松本雅則、小亀浩市、森内浩幸
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 8 Pages: 933-937
- DOI
  10.11406/rinketsu.58.933
- NAID
  130006067978
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation2017
- Author(s)
  Torrealba Natalia、Navarro-Marquez Mario、Garrido Valeria、Pedrozo Zully、Romero Diego、Eura Yuka、Villalobos Elisa、Roa Juan Carlos、Chiong Mario、Kokame Koichi、Lavandero Sergio
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 13402-13402
- DOI
  10.1038/s41598-017-13797-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358, KAKENHI-PROJECT-15K18510
[Journal Article] Consensus report on the diagnosis and management of thrombotic thrombocytopenic purpura 20172017
- Author(s)
  難治性疾患等政策研究事業「血液凝固異常症に関する調査研究班」TTPグループ、八木秀男、宮田敏行、村田満、松本雅則、藤村吉博、和田英夫、小亀浩市、宮川義隆、上田恭典、日笠聡、森木隆典
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 4 Pages: 271-281
- DOI
  10.11406/rinketsu.58.271
- NAID
  130006882225
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07358
[Journal Article] For TTP group of Blood Coagulation Abnormalities Research Team, Research on Rare and Intractable Disease supported by Health, Labour, and Welfare Sciences Research Grants.: Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) 2017 in Japan.2017
- Author(s)
  Matsumoto M, Fujimura Y, Wada H, Kokame K, Miyakawa Y, Ueda Y, Higasa S, Moriki T, Yagi H, Miyata T, Murata M;
- Journal Title
  
  Int J Hematol
  
  Volume: 106 Issue: 1 Pages: 3-15
- DOI
  10.1007/s12185-017-2264-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08645, KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-17K07358
[Journal Article] No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome2016
- Author(s)
  Toshiyuki Miyata, Yumiko Uchida, Yoko Yoshida, Hideki Kato, Masanori Matsumoto, Koichi Kokame, Yoshihiro Fujimura, and Masaomi Nangaku
- Journal Title
  
  Int. J. Hematol.
  
  Volume: 未定
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] 先天性TTP（血栓性血小板減少性紫斑病）の遺伝子解析2016
- Author(s)
  樋口（江浦）由佳, 小亀浩市
- Journal Title
  
  血栓と循環
  
  Volume: 24
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Journal Club2016
- Author(s)
  秋山正志、小亀浩市
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 27 Issue: 3 Pages: 384-385
- DOI
  10.2491/jjsth.27.384
- NAID
  130005157429
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08515
[Journal Article] Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency.2016
- Author(s)
  Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lammle B, Miyata T
- Journal Title
  
  Int J Hematol
  
  Volume: 103 Issue: 3 Pages: 283-291
- DOI
  10.1007/s12185-015-1933-7
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09463, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-15K18510
[Journal Article] No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome2016
- Author(s)
  Miyata T, Uchida Y, Yoshida Y, Kato H, Matsumoto M, Kokame K, Fujimura Y, Nangaku M
- Journal Title
  
  Int J Hematol
  
  Volume: 104 Issue: 2 Pages: 223-227
- DOI
  10.1007/s12185-016-2021-3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-15K09246
[Journal Article] 循環器疾患随伴後天性フォンウィルブランド症候群の臨床的インパクト2016
- Author(s)
  堀内久徳, 松本雅則, 小亀浩市
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 未定
- NAID
  130005157425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Deletion of Herpud1 Enhances Heme Oxygenase-1 Expression in a Mouse Model of Parkinson's Disease2016
- Author(s)
  Le TM, Hashida K, Ta HM, Takarada-Iemata M, Kokame K, Kitao Y, Hori O
- Journal Title
  
  Parkinsons Dis.
  
  Volume: 1 Pages: 1-9
- DOI
  10.1155/2016/6163934
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430069, KAKENHI-PROJECT-15K18374, KAKENHI-PUBLICLY-15H01374, KAKENHI-PROJECT-25440060
[Journal Article] Influence of a rotational speed modulation system used with an implantable continuous-flow left ventricular assist device (EVAHEART) on von Willebrand factor dynamics2016
- Author(s)
  Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, and Eisuke Tatsumi
- Journal Title
  
  Artif. Organs
  
  Volume: 未定 Issue: 9 Pages: 877-883
- DOI
  10.1111/aor.12666
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25560217, KAKENHI-PROJECT-25293294, KAKENHI-PROJECT-15K18510, KAKENHI-PROJECT-16K09834
[Journal Article] Exacerbated venous thromboembolism in mice carrying protein S K196E mutation2015
- Author(s)
  Fumiaki Banno, Toshiyuki Kita, Jose A. Fernandez, Hiroji Yanamoto, Yuko Tashima, Koichi Kokame, John H. Griffin, and Toshiyuki Miyata
- Journal Title
  
  Blood
  
  Volume: 126 Issue: 19 Pages: 2247-2253
- DOI
  10.1182/blood-2015-06-653162
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25461465
[Journal Article] ELISA-based detection system for protein S K196E mutation, a genetic risk factor for venous thromboembolism2015
- Author(s)
  Maruyama K, Akiyama M, Kokame K, Sekiya A, Morishita E, Miyata T
- Journal Title
  
  PLoS One
  
  Volume: 10 Issue: 7 Pages: e0133196-e0133196
- DOI
  10.1371/journal.pone.0133196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08643, KAKENHI-PROJECT-15K19176, KAKENHI-PROJECT-25440060
[Journal Article] Ndrg1 is a T cell clonal anergy factor negatively regulated by CD28-costimulation and interleukin-22015
- Author(s)
  Yu Mi Oh, Hyung Bae Park, Jae Hun Shin, Ji Eun Lee, Ha Young Park, Dhong Hyo Kho, Jun Sung Lee, Heonsik Choi, Tomohiko Okuda, Koichi Kokame, Toshiyuki Miyata, In-Hoo Kim, Seung Hoon Lee, Ronald Schwartz, and Kyungho Choi
- Journal Title
  
  Nat. Commun.
  
  Volume: 6 Issue: 1 Pages: 8698-8698
- DOI
  10.1038/ncomms9698
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] 血栓性血小板減少性紫斑病2015
- Author(s)
  小亀浩市
- Journal Title
  
  血液フロンティア
  
  Volume: 25 Pages: 51-57
- NAID
  130004920625
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] TTPの分子診断2014
- Author(s)
  小亀浩市
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 25 Pages: 689-696
- NAID
  130004847353
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] 血栓性血小板減少性紫斑病2014
- Author(s)
  藤村吉博，松本雅則，石西綾美，八木秀男，小亀浩市，宮田敏行
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 93-104
- NAID
  130004920625
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Candidate gene analysis using genomic quantitative PCR: identification of ADAMTS13 large deletions in two patients with Upshaw-Schulman syndrome.2014
- Author(s)
  Eura Y, Kokame K, Takafuta T, Tanaka R, Kobayashi H, Ishida F, Hisanaga S, Matsumoto M, Fujimura Y, Miyata T.
- Journal Title
  
  olecular Genetics & Genomic Medicine.
  
  Volume: 2 Issue: 3 Pages: 240-244
- DOI
  10.1002/mgg3.64
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25461456
[Journal Article] Case of maternal and fetal deaths due to severe congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) during pregnancy.2014
- Author(s)
  Tanaka H, Tenkumo C, Mori N, Kokame K, Fujimura Y, Hata T.
- Journal Title
  
  J Obset Gynaecol Res.
  
  Volume: 40 Issue: 1 Pages: 247-249
- DOI
  10.1111/jog.12125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-25440060
[Journal Article] Upshaw-Schulman症候群のADAMTS13遺伝子解析2014
- Author(s)
  小亀浩市，樋口（江浦）由佳
- Journal Title
  
  細胞
  
  Volume: 46 Pages: 61-63
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] ターゲット領域の異常を見逃さないゲノム定量PCR法の確立：ダイレクトシークエンシング法の弱点を補う解析方法として2014
- Author(s)
  樋口(江浦)由佳、小亀浩市、宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 25 Pages: 615-618
- NAID
  130004700440
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390250
[Journal Article] NDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury2014
- Author(s)
  Jacob Larkin, Baosheng Chen, Xiao-Hua Shi, Takuya Mishima, Koichi Kokame, Yaacov Barak, and Yoel Sadovsky
- Journal Title
  
  Endocrinology
  
  Volume: 155 Issue: 3 Pages: 1099-1106
- DOI
  10.1210/en.2013-1425
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Nonsynonymous mutations in three anticoagulant genes in Japanese patients with adverse pregnancy outcomes.2014
- Author(s)
  Neki R, Miyata T, Fujita T, Kokame K, Fujita D, Isaka S, Ikeda T, Yoshimatsu J
- Journal Title
  
  Thromb Res
  
  Volume: 133 Issue: 5 Pages: 914-918
- DOI
  10.1016/j.thromres.2014.02.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-26462507
[Journal Article] 血栓性血小板減少性紫斑病2014
- Author(s)
  藤村吉博、松本雅則、石西綾美、八木秀男、小亀浩市、宮田敏行
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 93-104
- NAID
  130004920625
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390250
[Journal Article] A first bout of thrombotic thrombocytopenic purpura triggered by herpes simplex infection in a 45-year-old nulliparous female with Upshaw-Schulman syndrome2014
- Author(s)
  Masanobu Morioka, Masanori Matsumoto, Makoto Saito, Koichi Kokame, Toshiyuki Miyata, and Yoshihiro Fujimura
- Journal Title
  
  Blood Transfus.
  
  Volume: 12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] ターゲット領域の異常を見逃さないゲノム定量PCR法の確立2014
- Author(s)
  樋口（江浦）由佳，小亀浩市，宮田敏行
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 25 Pages: 615-618
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] 先天性ADAMTS13欠損症2013
- Author(s)
  宮田敏行、小亀浩市、小久保喜弘
- Journal Title
  
  臨床検査
  
  Volume: 57 Pages: 556-561
- Data Source
  KAKENHI-PROJECT-24390250
[Journal Article] Auto-adaptive ER-associated degradation defines a pre-emptive unfolded protein response pathway2013
- Author(s)
  Riccardo Bernasconi, Carmela Galli, Koichi Kokame, and Maurizio Molinari
- Journal Title
  
  Mol. Cell
  
  Volume: 52 Issue: 6 Pages: 783-793
- DOI
  10.1016/j.molcel.2013.10.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy-related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells2013
- Author(s)
  Yoshie Takizawa, Yukiko Kosuge, Hiroyo Awaji, Emi Tamura, Ayako Takai, Takaaki Yanai, Reiko Yamamoto, Koichi Kokame, Toshiyuki Miyata, Rieko Nakata, and Hiroyasu Inoue
- Journal Title
  
  Brit. J. Nutr.
  
  Volume: 110 Issue: 12 Pages: 2150-2155
- DOI
  10.1017/s0007114513001670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] Long term follow up of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndorome) on hemodialysis for 19 years: a case report2013
- Author(s)
  Mise K, Ubara Y, Matsumoto M, Sumida K, Hiramatsu R, Hasegawa E, Yamanouchi M, Hayami N, Suwabe T, Hoshino J, Sawa N, Ohashi K, Kokame K, Miyata T, Fujimura Y, Takaichi K.
- Journal Title
  
  BMC Nephrol.
  
  Volume: 14 Issue: 1 Pages: 156-156
- DOI
  10.1186/1471-2369-14-156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25461456
[Journal Article] ADAMTS13 activity and genetic mutations in Japanese subjects.2013
- Author(s)
  Toshiyuki Miyata, Koichi Kokame, Masanori Matsumoto, and Yoshihiro Fujimura.
- Journal Title
  
  Haemostaselolgie
  
  Volume: 33 Issue: 02 Pages: 131-137
- DOI
  10.5482/hamo-12-11-0017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060
[Journal Article] A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in apoE knockout mice by attenuating inflammatory responses2013
- Author(s)
  Shohei Shinozaki, Tsuyoshi Chiba, Koichi Kokame, Toshiyuki Miyata, Eiji Kaneko, and Kentaro Shimokado
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 10 Pages: e75249-e75249
- DOI
  10.1371/journal.pone.0075249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25860231
[Journal Article] Crystal structure and enzymatic activity of an ADAMTS13 mutant with the East Asian-specific P475S polymorphism.2013
- Author(s)
  Masashi Akiyama, Daisuke Nakayama, Soichi Takeda, Koichi Kokame, Junichi Takagi, and Toshiyuki Miyata.
- Journal Title
  
  J. Thromb. Haemost.
  
  Volume: (In press) Issue: 7 Pages: 1399-1406
- DOI
  10.1111/jth.12279
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PLANNED-24111006, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-25440060
[Journal Article] Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism2013
- Author(s)
  Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  J Thromb Haemost
  
  Volume: 11 Pages: 1399-1406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] ADAMTS13と血栓性血小板減少性紫斑病2013
- Author(s)
  小亀浩市
- Journal Title
  
  循環器病研究の進歩
  
  Volume: 34 Pages: 69-75
- Data Source
  KAKENHI-PROJECT-25440060
[Journal Article] The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.2013
- Author(s)
  Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y.
- Journal Title
  
  Immunity
  
  Volume: 38 Issue: 6 Pages: 1105-1115
- DOI
  10.1016/j.immuni.2013.05.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591385, KAKENHI-PROJECT-23591387, KAKENHI-PROJECT-24390121, KAKENHI-PUBLICLY-25130712, KAKENHI-PROJECT-25293220, KAKENHI-PROJECT-25440060, KAKENHI-PROJECT-25461416, KAKENHI-PROJECT-25461439, KAKENHI-PROJECT-25670451
[Journal Article] Advances in ADAMTS13 research2012
- Author(s)
  宮田敏行・小亀浩市・秋山正志・坂野史明・中山大輔・武田壮一
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 53 Issue: 7 Pages: 672-679
- DOI
  10.11406/rinketsu.53.672
- NAID
  130004501705
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-22790923
[Journal Article] STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.2012
- Author(s)
  Sato T., et.al.
- Journal Title
  
  Molecular Cell
  
  Volume: 47(1) Issue: 1 Pages: 99-110
- DOI
  10.1016/j.molcel.2012.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J08328, KAKENHI-PROJECT-22390015, KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23590082, KAKENHI-PROJECT-23790095, KAKENHI-PROJECT-23790188, KAKENHI-PROJECT-23890146, KAKENHI-PROJECT-24300135, KAKENHI-PROJECT-24390418, KAKENHI-PROJECT-24790079, KAKENHI-PUBLICLY-23110504
[Journal Article] 重度高ホモシステイン血症マウスは血栓傾向を示さないというパラドックス2012
- Author(s)
  小亀浩市
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 23 Pages: 416-416
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion iniury2012
- Author(s)
  M.Fujioka, 他16名
- Journal Title
  
  Neurol Sci
  
  Volume: 33 Issue: 5 Pages: 1107-1115
- DOI
  10.1007/s10072-011-0913-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278, KAKENHI-PROJECT-21592313, KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-22790923, KAKENHI-PROJECT-23590654, KAKENHI-PROJECT-23659494, KAKENHI-PROJECT-24390250
[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction2012
- Author(s)
  Doi M, Matsui H, Takeda H, Saito Y, Takeda M, Matsunari Y, Nishio K, Shima M, Banno F, Akiyama M, Kokame K, Miyata T, Sugimoto M.
- Journal Title
  
  Thromb Haemost
  
  Volume: 108 Pages: 1236-1238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] Binding of von Willebr and factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)2012
- Author(s)
  Yongchol Shin, Masashi Akiyama, Toshiyuki Miyata, et al
- Journal Title
  
  Journal of Biochemistry
  
  Volume: (in press) Issue: 3 Pages: 251-25
- DOI
  10.1093/jb/mvs066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500432, KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-24390250
[Journal Article] 小胞体ストレスと循環器疾患2012
- Author(s)
  小亀浩市・宮田敏行
- Journal Title
  
  生体の科学
  
  Volume: 33 Pages: 390-391
- URL
  http://www.igaku-shoin.co.jp/journalDetai1.do?journal=34660
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] 小胞体ストレスと循環器疾患2012
- Author(s)
  小亀浩市
- Journal Title
  
  生体の科学
  
  Volume: 63 Pages: 390-391
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] Binding of von Willebrand factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)2012
- Author(s)
  Shin Y, Akiyama M, Kokame K, Soejima K, Miyata T.
- Journal Title
  
  J Biochem
  
  Volume: 152 Pages: 251-258
- NAID
  10031166136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] ADAMTS13研究の最先端2012
- Author(s)
  宮田敏行、小亀浩市、秋山正志、坂野史明、中山大輔、武田壮一
- Journal Title
  
  臨床血液
  
  Volume: 53 Pages: 672-679
- NAID
  130004501705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23570155
[Journal Article] Derlin-l deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.2012
- Author(s)
  Yuka Eura, Hiroji Yanamoto, Yuji Arai, Tomohiko Okuda, Toshiyuki Miyata, and Koichi Kokame.
- Journal Title
  
  PLoS One
  
  Volume: 7 Issue: 3 Pages: e34298-e34298
- DOI
  10.1371/journal.pone.0034298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] ADAMTS13 safeguards the myocardium in a mouse model of acute myocardial infarction.2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
- Journal Title
  
  Thromb. Haemost.
  
  Volume: 108 Issue: 12 Pages: 1236-1238
- DOI
  10.1160/th12-09-0674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-22790923, KAKENHI-PROJECT-23570155, KAKENHI-PROJECT-23659494, KAKENHI-PROJECT-24390250, KAKENHI-PROJECT-24592744
[Journal Article] The effect of Ndrg2 expression on astroglial activation.2011
- Author(s)
  Toshiaki Takeichi, Mika Takarada-Iemata, Koji Hashida, Hirofumi Sudo, Tomohiko Okuda, Koichi Kokame, Taku Hatano, Masashi Takanashi, Sayaka Funabe, Nobutaka Hattori, Osamu Kitamura, Yasuko Kitao, and Osamu Hori.
- Journal Title
  
  Neurochem. Int.
  
  Volume: 59 Issue: 1 Pages: 21-27
- DOI
  10.1016/j.neuint.2011.03.019
- NAID
  120003221535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia.2011
- Author(s)
  Hitomi Yamamoto, Koichi Kokame, Tomohiko Okuda, Yukako Nakajo, Hiroji Yanamoto, and Toshiyuki Miyata.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 286 Pages: 26158-26165
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] Natural history of Upshaw-Schulman syndrome based on ADAMTS13 gene analysis in Japan2011
- Author(s)
  Y.Fujimura, 他7名
- Journal Title
  
  J Thromb Haemost
  
  Volume: 9(review) Pages: 283-301
- DOI
  10.1111/j.1538-7836.2011.04341.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278, KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23591425
[Journal Article] von Willebrand factor-to-ADAMTS13 ratio increases with age in a Japanese population2011
- Author(s)
  K. Kokame, T. Sakata, Y. Kokubo, T. Miyata
- Journal Title
  
  J Thromb Haemost
  
  Volume: 9 Pages: 1426-1428
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] (*equalcontribution) Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1 and heat shock factor pathways2011
- Author(s)
  Hatori,M.*, Hirota,T., Fukada,Y.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 108 Issue: 12 Pages: 4864-4869
- DOI
  10.1073/pnas.1015959108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19107002, KAKENHI-PROJECT-19108002, KAKENHI-PLANNED-22132004, KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-22570151
[Journal Article] Genetic analysis of patients with deep vein thrombosis during pregnancy and postpartum2011
- Author(s)
  R. Neki, T. Fujita, K. Kokame, I. Nakanishi, M. Waguri, Y. Imayoshi, N. Suehara, T. Ikeda, T. Miyata
- Journal Title
  
  Int J Hematol
  
  Volume: 94 Issue: 2 Pages: 150-155
- DOI
  10.1007/s12185-011-0902-z
- NAID
  10029537014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278, KAKENHI-PROJECT-22570151
[Journal Article] Polymorphisms and mutations of ADAMTS13 in the Japanese population and estimation of the number of patients with Upshaw-Schulman syndrome2011
- Author(s)
  K. Kokame, Y. Kokubo, T. Miyata
- Journal Title
  
  J Thromb Haemost
  
  Volume: 9 Issue: 8 Pages: 1654-1656
- DOI
  10.1111/j.1538-7836.2011.04399.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278, KAKENHI-PROJECT-22570151
[Journal Article] ADAMTS13 of Japanese people2011
- Author(s)
  小亀浩市
- Journal Title
  
  Japanese Journal of Thrombosis and Hemostasis
  
  Volume: 22 Issue: 6 Pages: 368-373
- DOI
  10.2491/jjsth.22.368
- NAID
  10031144654
- ISSN
  0915-7441, 1880-8808
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] ER-stress-inducible Herp, facilitates the degradation of immature nicastrin.2011
- Author(s)
  Toshihiro Marutani, Tomoji Maeda, Chiaki Tanabe, Kun Zou, Wataru Araki, Koichi Kokame, Makoto Michikawa, and Hiroto Komano.
- Journal Title
  
  Biochim. Biophys. Acta-General Subjects
  
  Volume: 1810 Issue: 8 Pages: 790-798
- DOI
  10.1016/j.bbagen.2011.04.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151, KAKENHI-PROJECT-23590110
[Journal Article] ADAMTS13の生理的役割と病態への関与について教えてください2011
- Author(s)
  小亀浩市
- Journal Title
  
  血栓と循環
  
  Volume: 19 Pages: 12-14
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] Gene and protein analysis of brain derived neurotrophic factor expression in relation to neurological recovery induced by an enriched environment in a rat stroke model.2011
- Author(s)
  Kenji Hirata, Yuji Kuge, Chiaki Yokota, Akina Harada, Koichi Kokame, Hiroyasu Inoue, Hidekazu Kawashima, Hiroko Hanzawa, Yuji Shono, Hideo Saji, Kazuo Minematsu, and Nagara Tamaki.
- Journal Title
  
  Neurosci. Lett.
  
  Volume: 495 Issue: 3 Pages: 210-215
- DOI
  10.1016/j.neulet.2011.03.068
- NAID
  120003089244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] Gene expression associated with an enriched environment after transient focal ischemia.2011
- Author(s)
  Yuji Shono, Chiaki Yokota, Yuji Kuge, Shinsuke Kido, Akina Harada, Koichi Kokame, Hiroyasu Inoue, Mariko Hotta, Kenji Hirata, Hideo Saji, Nagara Tamaki, and Kazuo Minematsu.
- Journal Title
  
  Brain Res.
  
  Volume: 1376 Pages: 60-65
- DOI
  10.1016/j.brainres.2010.12.058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] von Willebrand factor-to-ADAMTS13 ratio increases with age in a Japanese population.2011
- Author(s)
  Koichi Kokame, Toshiyuki Sakata, Yoshihiro Kokubo, and Toshiyuki Miyata.
- Journal Title
  
  J. Thromb. Haemost.
  
  Volume: 9 Issue: 7 Pages: 1426-1428
- DOI
  10.1111/j.1538-7836.2011.04333.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] ADAMTS13 gene deletion aggravates ischemic brain damage : a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion2010
- Author(s)
  M. Fujioka, K. Hayakawa, K. Mishima, A. Kunizawa, K. Irie, S. Higuchi, T. Nakano, C. Muroi, H. Fukushima, M. Sugimoto, F. Banno, K. Kokame, T. Miyata, M. Fujiwara, K. Okuchi, K. Nishio
- Journal Title
  
  Blood
  
  Volume: 15 Issue: 8 Pages: 1650-1653
- DOI
  10.1182/blood-2009-06-230110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278, KAKENHI-PROJECT-22790923
[Journal Article] ADAMTS13 gene deletion aggravates ischemic brain damage : a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion.2010
- Author(s)
  M.Fujioka, K.Hayakawa, K.Mishima, A.Kunizawa, K.Irie, S.Higuchi, T.Nakano, C.Muroi, H.Fukushima, M.Sugimoto, F.Banno, K.Kokame, T.Miyata, M.Fujiwara, K.Okuchi, K.Nishio
- Journal Title
  
  Blood 115
  
  Pages: 1650-1653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] WF切断酵素ADAMTS13のエキソサイト認識機構2010
- Author(s)
  秋山正志・武田壮一・小亀浩市・高木淳一・宮田敏行
- Journal Title
  
  生化学
  
  Volume: 82 Pages: 950-956
- URL
  http://www.jbsoc.or.jp/event/magazine/pdf/82-10-05.pdf
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] VWF切断酵素ADAMTS13のエキソサイト認識機構2010
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Journal Title
  
  生化学第82巻、第10号
  
  Pages: 950-956
- NAID
  10027502769
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Deletion of Herp facilitates degradation of cytosolic proteins.2010
- Author(s)
  Hikari Miura, Koji Hashida, Hirofumi Sudo, Yoshitaka Awa, Mika Takarada-Iemata, Koichi Kokame, Tetsuya Takahashi, Masayasu Matsumoto, Yasuko Kitao, and Osamu Hori.
- Journal Title
  
  Genes Cells
  
  Volume: 15 Issue: 8 Pages: 843-853
- DOI
  10.1111/j.1365-2443.2010.01422.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor2009
- Author(s)
  M. Akiyama, S. Takeda, K. Kokame, J. Takagi, T. Miyata
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 106 Issue: 46 Pages: 19274-19279
- DOI
  10.1073/pnas.0909755106
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation2009
- Author(s)
  F. Banno, A. Chauhan, K. Kokame, J. Yang, S. Miyata, D. Wagner, and T. Miyata
- Journal Title
  
  Blood 113
  
  Pages: 5323-5329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  Proc Natl Acad Sci USA 106
  
  Pages: 19274-19279
- NAID
  10026400518
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] 血栓性血小板減少性紫斑病・診断2009
- Author(s)
  小亀浩市
- Journal Title
  
  新しい診断と治療のABC 63
  
  Pages: 133-140
- Data Source
  KAKENHI-PROJECT-20059039
[Journal Article] The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation.2009
- Author(s)
  F.Banno, AK.Chauhan, K.Kokame, J.Yang, S.Miyata, DD.Wagner, T.Miyata
- Journal Title
  
  Blood 113
  
  Pages: 5323-5329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Journal Title
  
  Proc Natl Acad Sci USA 106(46):
  
  Pages: 19274-19279
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation2009
- Author(s)
  F. Banno, AK. Chauhan, K. Kokame, J. Yang, S. Miyata, DD. Wagner, T. Miyata
- Journal Title
  
  Blood
  
  Volume: 113 Pages: 5323-5329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T.
- Journal Title
  
  Acta crystallogr Sect F 65
  
  Pages: 739-742
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Pregnancy-induced thrombocytopenia and TTP, and the risk of fetal death, in Upshaw-Schulman syndrome: a series of 15 pregnancies in 9 genotyped patients2009
- Author(s)
  Y. Fujimura, M. Matsumoto, K. Kokame, A. Isonishi, K. Soejima, N. Akiyama, J. Tomiyama, K. Natori, Y. Kuranishi, Y. Imamura, N. Inoue, S. Higasa, M. Seike, T. Kozuka, M. Hara, H. Wada, M. Murata, Y. Ikeda, T. Miyata, and J. N. George
- Journal Title
  
  Br. J. Haematol 144
  
  Pages: 742-754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Journal Title
  
  Acta Crystallogr Sect F Struct Biol Cryst Commun 65(Pt7)
  
  Pages: 739-742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] Crystal structures of the non-catalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von willebrand factor.2009
- Author(s)
  M.Akiyama, S.Takeda, K.Kokame, J.Takagi, T.Miyata
- Journal Title
  
  Proc Natl Acad Sci 106
  
  Pages: 19274-19279
- NAID
  10026400518
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis2009
- Author(s)
  T. Miyata, Y. Sato, J. Ishikawa, H. Okada, S. Takeshita, T. Sakata, K. Kokame, R. Kimura, S. Honda, T. Kawasaki, E. Suehisa, H. Tsuji, S. Madoiwa, Y. Sakata, T. Kojima, M. Murata, Y. Ikeda
- Journal Title
  
  Thromb Res
  
  Volume: 124 Issue: 1 Pages: 14-18
- DOI
  10.1016/j.thromres.2008.08.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production2009
- Author(s)
  Y. Inaoka, T. Yazawa, T. Mizutani, K. Kokame, K. Kangawa, M. Uesaka, A. Umezawa, and K. Miyamoto
- Journal Title
  
  Reprod. Biol. Endocr. 6(62)
  
  Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice2009
- Author(s)
  T. Yokota, K. Oritani, S. Butz, K. Kokame, P. W. Kincade, T. Miyata, D. Vestweber, and Y. Kanakura
- Journal Title
  
  Blood 113
  
  Pages: 2914-2923
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis2009
- Author(s)
  T. Miyata, Y. Sato, J. Ishikawa, H. Okada, S. Takeshita, T. Sakata, K. Kokame, R. Kimura, S. Honda, T. Kawasaki, E. Suehisa, H. Tsuji, S. Madoiwa, Y. Sakata, T. Kojima, M. Murata, and Y. Ikeda
- Journal Title
  
  Thromb. Res. 124
  
  Pages: 14-18
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Inherited and de novo mutations of ADAMTS13 in a patient with Upshaw-Schulman syndrome2008
- Author(s)
  Kokame K
- Journal Title
  
  J Thromb Haemost 144
  
  Pages: 213-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390278
[Journal Article] ADAMTS13 P475S polymorphism causes a lowered enzymatic activity and urea lability in vitro2008
- Author(s)
  M. Akiyama, K. Kokame, and T. Miyata
- Journal Title
  
  J. Thromb. Haemost 6
  
  Pages: 1830-1832
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Differential expression patterns of NDRG family proteins in the central nervous system2008
- Author(s)
  T. Okuda, K. Kokame, and T. Miyata
- Journal Title
  
  J. Histochem. Cytochem. 56
  
  Pages: 175-182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] ADAMTS132008
- Author(s)
  小亀浩市
- Journal Title
  
  臨床検査 52
  
  Pages: 1566-1570
- NAID
  130007530558
- Data Source
  KAKENHI-PROJECT-20059039
[Journal Article] Inherited and de novo mutations of ADAMTS13 in a patient with Upshaw-Schulman syndrome.2008
- Author(s)
  K.Kokame
- Journal Title
  
  J Thromb Haemost. 6
  
  Pages: 213-215
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Second international collaborative study evaluating performance characteristics of methods measuring the von Willebrand factor cleaving protease (ADAMTS-13)2008
- Author(s)
  A. Tripodi, F. Peyvandi, V. Chantarangkul, R. Palla, A. Afrasiabi, M. T. Canciani, D. W. Chung, S. Ferrari, Y. Fujimura, M. Karimi, K. Kokame, J. A. Kremer Hovinga, B. Lammle, S. F. De Meyer, B. Plaimauer, K. Vanhoorelbeke, K. Varadi, and P. M. Mannucci
- Journal Title
  
  J. Thromb. Haemost 6
  
  Pages: 1534-1541
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] ADAMTS132008
- Author(s)
  小亀浩市
- Journal Title
  
  臨床検査 52
  
  Pages: 1566-1570
- NAID
  130007530558
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] von Willebrand 因子の活性を制御する酵素ADAMTS13の測定法2008
- Author(s)
  小亀浩市
- Journal Title
  
  血栓と循環 16
  
  Pages: 69-74
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Polycystin-2 is regulated by endoplasmic reticulum-associated degradation2008
- Author(s)
  G. Liang, Q. Li, Y. Tang, K. Kokame, T. Kikuchi, G. Wu, and X.-Z. Chen
- Journal Title
  
  Hum. Mol. Genet. 17
  
  Pages: 1109-1119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Inherited and novo mutations of ADAMTS13 in a patient with Upshaw-Schulman syndrome.2008
- Author(s)
  K. Kokame
- Journal Title
  
  J Thromb Haemost. 6
  
  Pages: 213-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] von Willebrand因子の活性を制御する酵素ADAMTS13の測定法2008
- Author(s)
  小亀浩市
- Journal Title
  
  血栓と循環 16
  
  Pages: 69-74
- Data Source
  KAKENHI-PROJECT-20059039
[Journal Article] ADAMTS13 P475S polymorphism causes a lowered enzymatic activity and urea lability in vitro.2008
- Author(s)
  Akiyama M, Kokame K, Miyata T.
- Journal Title
  
  J. Thromb. Haemost. 144
  
  Pages: 742-754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20570120
[Journal Article] VWF切断酵素ADAMTS13の遺伝子多型2008
- Author(s)
  小亀浩市
- Journal Title
  
  BRAIN and NERVE 60
  
  Pages: 1325-1332
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Inherited and de novo mutations of ADAMTS13 in a patient with Upshaw-Schulman syndrome.2008
- Author(s)
  K. Kokame, Y. Aoyama, M. Matsumoto, Y. Fujimura, T. Miyata
- Journal Title
  
  J Thromb Haemost 6
  
  Pages: 213-215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] VWF切断酵素ADAMTS13の遺伝子多型2008
- Author(s)
  小亀浩市
- Journal Title
  
  BRAIN and NERVE 60
  
  Pages: 1325-1332
- Data Source
  KAKENHI-PROJECT-20059039
[Journal Article] Inherited and de nove mutations of ADAMTS13 in a patient with Upshaw-Schulman syndrome.2008
- Author(s)
  Koichi Kokame
- Journal Title
  
  J. Thromb. Haemost. 6
  
  Pages: 213-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Inherited and de novo mutations of ADAMTS13 in a patient with Upshaw-Schulman syndrome2008
- Author(s)
  K. Kokame, Y. Aoyama, M. Matsumoto, Y. Fujimura, and T. Miyata
- Journal Title
  
  J. Thromb. Haemost. 6
  
  Pages: 213-215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Impaired mast cell maturation and degranulation and attenuated allergic responses in Ndrg1-deficient mice2007
- Author(s)
  Y. Taketomi, K. Sunaga, S. Tanaka, M. Nakamura, S. Arata, T. Okuda, T. C. Moon, H. W. Chang, Y. Sugimoto, K. Kokame, T. Miyata, M. Murakami, and I. Kudo
- Journal Title
  
  J. Immunol. 178
  
  Pages: 7042-7053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] ADAMTS13 assays and ADAMTS13-dificient mice.2007
- Author(s)
  T.Miyata, K. Kokame, F. Banno, Y. Shin, M. Akiyama
- Journal Title
  
  Curr Opin Hematol 14-3
  
  Pages: 277-283
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Subcellular stress response after traumatic brain injury2007
- Author(s)
  J.S. Truettner, B. Hu, O.F. Alonso, H.M. Bramlett, K. Kokame, and W.D. Dietrich
- Journal Title
  
  J. Neurotrauma 24
  
  Pages: 599-612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] ADAMTS13 assays and ADAMTS13-deficient mice2007
- Author(s)
  T. Miyata, K. Kokame, F. Banno, Y. Shin, and M. Akiyama
- Journal Title
  
  Curr. Opin. Hematol. 14
  
  Pages: 277-283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] ADAMTS13の測定2007
- Author(s)
  小亀浩市
- Journal Title
  
  日本血栓止血学会誌 18
  
  Pages: 234-240
- NAID
  10026114743
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Site-specific effect of estradiol on gene expression in the adipose tissue of ob/ob mice2007
- Author(s)
  S. Shinozaki, T. Chiba, K. Kokame, T. Miyata, M. Ai, A. Kawakami, E. Kaneko, M. Yoshida, and K. Shimokado
- Journal Title
  
  Horm. Metab. Res. 39
  
  Pages: 192-196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Novel compound heterozygote mutations (H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure.2006
- Author(s)
  Shibagaki Y, Matsumoto M, Kokame K, Ohba S, Miyata T, Fujimura Y, Fujita T
- Journal Title
  
  Nephrol Dial Transplant 21
  
  Pages: 1289-1292
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] ADAMTS13の測定2006
- Author(s)
  小亀浩市
- Journal Title
  
  International Review of Thrombosis 1 (4)
  
  Pages: 266-270
- NAID
  10026114743
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] Complete dificiency in ADAMTS13 is prothrombotic,but it alone is not sufficient to cause thrombotic thrombocytopenic purpura.2006
- Author(s)
  Banno F, Kokame K, Okuda T, Honda S, Miyata S, Kato H, Tomiyama Y, Miyata T
- Journal Title
  
  Blood 107
  
  Pages: 3161-3166
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura2006
- Author(s)
  F.Banno, K.Kokame, T.Okuda, S.Honda, S.Miyata, H.Kato, Y.Tomiyama, T.Miyata.
- Journal Title
  
  Blood 107(in press)
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thiombotic thrombocytopenic purpura.2006
- Author(s)
  F. Banno, K. Kokame, T. Okuda, S. Honda, S. Miyata, H. Kato, Y. Tomiyama, T. Miyata
- Journal Title
  
  Blood 107-8
  
  Pages: 3161-3166
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] Measurement of ADAMTS132006
- Author(s)
  Koichi Kokame
- Journal Title
  
  International Review of Thrombosis 1(4)
  
  Pages: 266-270
- NAID
  10026114743
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] Novel compound heterozygote mutations(H234Q/R1206X) of the ADAMTS13 gene in an adult patient with Upshaw-Schulman syndrome showing predominant episodes of repeated acute renal failure.2006
- Author(s)
  Y. Shibagaki, M. Matsumoto, K. Kokame, S. Ohba, T. Miyata, Y. Fujimura, T. Fujita
- Journal Title
  
  Nephrol Dial Transplant 21-5
  
  Pages: 1289-1292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay2005
- Author(s)
  Koichi Kokame
- Journal Title
  
  Br.J.Haematol. 129(1)
  
  Pages: 93-100
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] ミニレビュー/細胞ストレス応答遺伝子NDRG1の機能解析2005
- Author(s)
  奥田智彦, 小亀浩市, 宮田敏行
- Journal Title
  
  生化学 (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570107
[Journal Article] FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay2005
- Author(s)
  Koichi Kokame
- Journal Title
  
  Br. J. Haematol. 129(1)
  
  Pages: 93-100
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] Measurement of ADAMTS 13 activity and inhibitors.2005
- Author(s)
  T.Miyata, K.Kokame, F.Banno
- Journal Title
  
  Curr Opin Hematol 12(5)
  
  Pages: 384-389
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay2005
- Author(s)
  K. Kokame, Y. Nobe, Y. Kokubo, A. Okayama, T. Miyata
- Journal Title
  
  Br J Haematol 129-1
  
  Pages: 93-100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] 血栓性血小板減少性紫斑病/溶血性尿毒症症候群2005
- Author(s)
  小亀浩市
- Journal Title
  
  分子細胞治療 4(3)
  
  Pages: 209-215
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] FRETS-VWF73, a first fluorogenic substsrate for ADAMTS13 assay.2005
- Author(s)
  K.Kokame, Y.Nobe, Y.Kokubo, A.Okayama, T.Miyata
- Journal Title
  
  Br.J.Haematol 129(1)
  
  Pages: 93-100
- Data Source
  KAKENHI-PROJECT-17390285
[Journal Article] TTP迅速診断を目的とした新規ADAMTS13測定法の開発と応用2005
- Author(s)
  小亀浩市
- Journal Title
  
  臨床病理 53(7)
  
  Pages: 639-645
- NAID
  10018039920
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] Identification of strain-specific variants of mouse Adamts13 gene encodingvon Willebrand factor-cleaving protease.2004
- Author(s)
  Banno F, Kaminaka K, Soejima K, Kokame K, Miyata T
- Journal Title
  
  J Biol Chem 279・29
  
  Pages: 30896-30903
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570107
[Journal Article] Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves.2004
- Author(s)
  Okuda T, Higashi Y, Kokame K, Tanaka C, Kondoh H, Miyata T
- Journal Title
  
  Mol Cell Biol 24・9
  
  Pages: 3949-3956
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570107
[Journal Article] FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay.
- Author(s)
  Koichi Kokame
- Journal Title
  
  Br.J.Haematol. (in press)
- Data Source
  KAKENHI-PROJECT-15032267
[Journal Article] FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay.
- Author(s)
  Koichi Kokame
- Journal Title
  
  Br.J.Haematol. (in press)
- Data Source
  KAKENHI-PROJECT-15770093
[Journal Article] ADAMTS13の測定
- Author(s)
  小亀浩市
- Journal Title
  
  日本血栓止血学会誌 (印刷中)
- NAID
  10026114743
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570126
[Journal Article] Hypoxia-inducible factor-3α functions as an accelerator of 3T3-L1 adipose differentiation
- Author(s)
  M. Hatanaka, S. Shimba, M. Sakaue, Y. Kondo, H. Kagechika, K. Kokame, T. Miyata, and S. Hara
- Journal Title
  
  Biol. Pharm. Bull. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570147
[Journal Article] Upregulation of eNOS, SIRT1, and autophagy-related genes by repeated treatment with resveratrol in human umbilical vein endothelial cells.
- Author(s)
  Yoshie Takizawa, Yukiko Kosuge, Hiroyo Awaji, Emi Tamura, Ayako Takai, Takaaki Yanai, Reiko Yamamoto, Koichi Kokame, Toshiyuki Miyata, Rieko Nakata, and Hiroyasu Inoue.
- Journal Title
  
  Brit. J. Nutr.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570151
[Patent] フォンビルブランド因子切断酵素の特異的基質および活性測定法2002
- Inventor(s)
  宮田敏行, 小亀浩市
- Industrial Property Rights Holder
  国立循環器病センター総長
- Industrial Property Number
  2004-544704
- Filing Date
  2002
- Data Source
  KAKENHI-PROJECT-15770093
[Presentation] ロングリードのターゲットシーケンシングと全ゲノムシーケンシングを併用したADAMTS13遺伝子解析2023
- Author(s)
  樋口(江浦)由佳、叶盛、松本雅則、小亀浩市
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] Comparison of VWF:RCo/VWF:Ag ratios with the VWF large multimer indices in patients with aortic stenosis2023
- Author(s)
  Hisanori Horiuchi, Noriyuki Okubo, Shingo Sugawara, Tohru Fujiwara, Yuka Eura, Koichi Kokame, Masaki Hayakawa, Masanori Matsumoto, Yasunori Kawate, Shin-ichi Fujimaki
- Organizer
  The 31st Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] Long range PCRを用いたロングリードシーケンシングのフェージング攻略法2023
- Author(s)
  樋口(江浦)由佳、叶盛、松本雅則、小亀浩市
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] 大動脈弁狭窄症症例における凝固第VIII因子活性とフォンヴィレブランド因子活性（VWF:RCo）、抗原量（VWF:Ag）の関係についての検討2023
- Author(s)
  堀内久徳、大久保礼由、菅原新吾、藤原亨、樋口(江浦)由佳、小亀浩市、早川正樹、松本雅則、川手康徳、藤巻慎一
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] プロテインＳとTAM受容体を介した血管内皮細胞における血液脳関門保護機能2023
- Author(s)
  秋山正志、Teena Bhakuni、小亀浩市
- Organizer
  第69回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] VWF遺伝子解析の困難性を克服するロングリードシーケンシング法の構築2023
- Author(s)
  叶盛、樋口(江浦)由佳、松本雅則、小亀浩市
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] 大動脈弁狭窄症に随伴する後天性フォンヴィレブランド症候群の診断におけるVWF:RCo/VWF:Agの有用性についての検討2023
- Author(s)
  堀内久徳、大久保礼由、菅原新吾、藤原亨、樋口(江浦)由佳、小亀浩市、早川正樹、松本雅則、川手康徳、藤巻慎一
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] Weibel-Palade小体の形成過程で内腔はV-ATPaseにより酸性化される2023
- Author(s)
  山崎泰男、小亀浩市
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] プロテインＳ遺伝子のイントロン１に同定した転写調節領域の機能解析2023
- Author(s)
  丸山慶子、小亀浩市
- Organizer
  第45回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-23K27372
[Presentation] 遺伝カウンセリング外来来談者における遺伝性血栓性素因の遺伝子解析および患者背景に関する検討2021
- Author(s)
  根木玲子、伊田和史、丸山慶子、辻明宏、宮田敏行、小亀浩市
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] ADAMTS13およびVWFのエンドサイトーシスに関わるSiglecsの機能解析2021
- Author(s)
  秋山正志、小亀浩市
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] Protein S attenuates high glucose-indued damage in blood-brain barrier endothelial cells.2021
- Author(s)
  Teena Bhakuni, Masashi Akiyama, Koichi Kokame
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] アンチトロンビン抵抗性を示すプロトロンビン変異を伴う３症例の検討2021
- Author(s)
  辻明宏、関根章博、浅野遼太郎、上田仁、青木竜男、保山美由紀、根木玲子、小亀浩市、宮田敏行、大郷剛
- Organizer
  第43回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] Biochemical and genetic analyses of complement-related factors in Japanese patients with hypertensive disorders of pregnancy2020
- Author(s)
  Neki R, Miyata T, Ohtani K, Hidaka Y, Ida K, Yokouchi-Konishi T, Nakanishi A, Yoshimatsu J, Kokame K, Wakamiya N, Inoue N
- Organizer
  The XXVIII Congress of the International Society on Thrombosis and Haemostasis (ISTH 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] プロテインS(PS)比活性検査およびPS-K196E変異検出ELISAのPS-K196E変異予測精度に関する検討2020
- Author(s)
  三好剛一、丸山慶子、根木玲子、吉松　淳、浅原彩子、奥久人、小亀浩市、宮田敏行
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] 新規ADANTS13クリアランス受容体SIGLEC5およびSIGLEC14の機能解析2020
- Author(s)
  秋山正志、樋口（江浦）由佳、小亀浩市
- Organizer
  第42回日本血栓止血学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] 特発性血栓症患者のゲノム情報を用いた層別化による病態解明研究2020
- Author(s)
  辻明宏、和田英夫、森下英理子、野上恵嗣、荻原義人、松下正、小嶋哲人、大郷剛、根木玲子、小亀浩市、安田聡、関根章博、宮田敏行
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] 肝星細胞におけるADAMTS13の遺伝子発現調節2020
- Author(s)
  三島優一、秋山正志、小亀浩市
- Organizer
  第42回日本血栓止血学会学術総会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] Genetic study for idiopathic venous thromboembolism in Japanese using short-read and long read sequencers, a pilot study of Japanese Group of Idiopathic Thromboembolism2020
- Author(s)
  Tsuji A, Sekine A, Wada H, Morishita E. Ogihara Y, Nogami K, Kojima T, Matsushita T, Yamada N, Ogo T, Neki R, Kokame K, Yasuda S, MiyataT
- Organizer
  The XXVIII Congress of the International Society on Thrombosis and Haemostasis (ISTH 2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] 当院の遺伝カウンセリング外来来談者における遺伝性血栓性素因の遺伝子解析の検討2020
- Author(s)
  伊田和史、丸山慶子、辻明宏、宮田敏行、小亀浩市、根木玲子
- Organizer
  第44回日本遺伝カウンセリング学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] Kindkin-3欠損血小板の血栓形成が明らかにする血栓形成メカニズム2020
- Author(s)
  加藤恒、伊藤康彦、柏木浩和、西浦伸子、芥田敬吾、小亀浩市、宮田敏行、保仙直毅、金倉譲、冨山佳昭
- Organizer
  第42回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] Effects of Low-dose Combined Oral Contraceptives and Protein S K196E Mutation on Anticoagulation Factors: A Prospective Observational Study2019
- Author(s)
  T. Miyoshi, H. Oku, S. Asahara, A. Okamoto, K. Kokame, M. Nakai, K. Nishimura, F. Otsuka, A. Higashiyama, J. Yoshimatsu, T. Miyata
- Organizer
  The 27th Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08875
[Presentation] 公開データベースから抽出したプロテインＳ変異の機能解析2019
- Author(s)
  丸山慶子、小亀浩市
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] プロトンポンプV-ATPaseはvon Willebrand因子の細胞内貯蔵オルガネラであるWeibel-Palade小体に局在する2019
- Author(s)
  山崎泰男、樋口(江浦)由佳、小亀浩市
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] Safety and efficacy of argatroban therapy using ethnic-specific doses in Japanese patients suspected of having heparin-induced thrombocytopenia: nationwide post-marketing surveillance studies2019
- Author(s)
  Miyata Shigeki、Nakamura Y、Kuramochi K、Sawada O、Kokame Koichi、Maeda Takuma
- Organizer
  The 27th Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] シェディング酵素ADAMファミリープロテアーゼの成熟化とプロドメインによる活性制御の構造基盤2019
- Author(s)
  武田壮一、秋山正志、荒木聡彦、小亀浩市、James Pearson
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] シェディング酵素ADAMファミリープロテアーゼの成熟化とプロドメインによる活性制御の構造基盤2019
- Author(s)
  武田壮一、秋山正志、荒木聡彦、小亀浩市、James Pearson
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] ADAMTS13クリアランス受容体としてのSIGLEC5の同定と機能解析2019
- Author(s)
  秋山正志、樋口(江浦)由佳、小亀浩市
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] ADAMTS13クリアランス受容体としてのSIGLEC5の同定と機能解析2019
- Author(s)
  秋山正志、樋口（江浦）由佳、小亀浩市
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08829
[Presentation] Effects of low-dose combined oral contraceptives and protein S K196E mutation on anticoagulation factors: a prospective observational study2019
- Author(s)
  Miyoshi Takekazu、Oku Hisato、Asahara Saiko、Okamoto Akira、Kokame Koichi、Nakai M、Nishimura K、Otsuka F、Higashijima J、Yoshimatsu Jun、Miyata Toshiyuki
- Organizer
  The 27th Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 家系構成員の遺伝子解析が発端者の診断に有用であった遺伝性血栓性素因患者における遺伝子解析の検討2019
- Author(s)
  根木玲子、伊田和史、光黒真菜、岡本章、柏木浩和、丸山慶子、小亀浩市
- Organizer
  第41回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 妊娠を契機に深部静脈血栓症を発症した先天性アンチトロンビン欠乏症症例の遺伝学的検査の検討2018
- Author(s)
  根木玲子、伊田和史、光黒真菜、岡本章、丸山慶子、小亀浩市、宮田敏行
- Organizer
  日本人類遺伝学会第63回大会
- Data Source
  KAKENHI-PROJECT-16K09834
[Presentation] Derlin-3は造血・免疫系組織で発現し、マウスではDerlin-3欠損により血清IgG濃度が減少する2018
- Author(s)
  吉田亜佑美・樋口（江浦）由佳・小亀浩市
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] Quantitative analysis of VWF large multimer may predict bleeding risk in patients with aortic stenosis2018
- Author(s)
  Tsuyoshi Doman, Masanori Matsumoto, Koichi Kokame, Hisanori Horiuchi on beharf of the AVeC study group
- Organizer
  The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] von Willebrand因子の分泌におけるエンドソームの関与2018
- Author(s)
  山崎泰男・樋口(江浦)由佳・小亀浩市
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 閉経後に深部静脈血栓症を発症した先天性プロテインS欠乏症の検討2018
- Author(s)
  根木玲子、伊田和史、光黒真菜、岡本章、小亀浩市、宮田敏行
- Organizer
  第33回日本女性医学学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09834
[Presentation] Is the ratios of VWF:RCo to VWF:Ag useful for the diagnosis of AVWS associated with LVAD?2018
- Author(s)
  Tsuyoshi Doman, Shingo Sugawara, Koichi Kokame, Masanori Matsumoto, Shin-ichi Fujimaki, Yoshikatsu Saiki, Hisanori Horiuchi on beharf of the AVeC study group
- Organizer
  The International Society for Mechanical Circulatory Support (ISMCS) 2018
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 濃厚な家族歴を有する静脈血栓症症例における先天性プロテインS欠乏症の遺伝子解析の検討2018
- Author(s)
  根木玲子・伊田和史・光黒真菜・岡本章・柳生剛・小亀浩市・宮田敏行
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 妊娠を契機に深部静脈血栓症を発症した先天性アンチトロンビン欠乏症症例の遺伝学的検査の検討2018
- Author(s)
  根木玲子・伊田和史・光黒真菜・岡本章・小亀浩市・宮田敏行
- Organizer
  第33回日本女性医学学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 血小板機能異常症におけるフィブリノゲン受容体インテグリンαIIbβ3活性化キネティクスの評価2018
- Author(s)
  加藤恒・柏木浩和・森川陽一郎・芥田敬吾・西浦伸子・本田繁則・小亀浩市・宮田敏行・金倉譲，冨山佳昭
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] Correlation of the ratios of von Willebrand factor (VWF) ristocetin cofactor activity to VWF antigen amount with the VWF large multimer levels evaluated with its multimer analysis2018
- Author(s)
  Shingo Sugawara, Tsuyoshi Doman, Koichi Kokame, Masanori Matsumoto, Shin-ichi Fujimaki, Hisanori Horiuchi on beharf of the AVeC study group
- Organizer
  The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] インテグリンαIIbβ3活性化変異αIIb (R990W)ノックインマウスにおける血小板産生障害2018
- Author(s)
  芥田敬吾・清水一亘・柏木浩和・國島伸治・坂野史明・小亀浩市・西浦伸子・森川陽一郎・加藤恒・本田繁則・金倉譲・宮田敏行・冨山佳昭
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] Impact of different oral contraceptives on anticoagulation factors in Japanese women2018
- Author(s)
  Miyoshi T, Okamoto A, Mitsuguro M, Neki R, Uchida Y, Kokame K, Miyata T
- Organizer
  第40回日本血栓止血学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09834
[Presentation] 濃厚な家族歴を有する静脈血栓症症例における先天性プロテインS欠乏症の遺伝子解析の検討2018
- Author(s)
  根木玲子、伊田和史、光黒真菜、岡本章、柳生剛、小亀浩市、宮田敏行
- Organizer
  第40回日本血栓止血学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09834
[Presentation] Platelet aggregation balanced by von Willebrand factor (VWF) and ADAMTS132017
- Author(s)
  Koichi Kokame
- Organizer
  ACCDiS Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 活性化プロテインC（APC）の急性期投与がマウス脳梗塞の進展を抑制する2017
- Author(s)
  大和恵子、中城有香子、井本(山本)ひとみ、小亀浩市、宮田敏行、片岡大治、髙橋淳、柳本広二
- Organizer
  日本脳神経外科学会第76回学術総会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 先天性TTPの遺伝子解析を通して分かること2017
- Author(s)
  小亀浩市
- Organizer
  第39回日本血栓止血学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] A proposal of VWF large multimer index for standardization of the quantitative description of VWF multimers among laboratories2017
- Author(s)
  Hisanori Horiuchi, Masanori Matsumoto, Koichi Kokame
- Organizer
  The 63rd Annual Scientific and Standardization Committee Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 静脈血栓症の再発を認めたプロテインS欠乏症患者におけるPROS1遺伝子解析2017
- Author(s)
  伊田和史、根木玲子、光黒真菜、岡本章、辻明宏、小亀浩市、宮田敏行
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] Genetic, biochemical, and physiological approach to understanding the function of Herp and Derlin family proteins in ER-associated degradation machinery2017
- Author(s)
  Koichi Kokame, Yuka Eura
- Organizer
  XL Annual Meeting of Chilean BMB Society
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] Mouse geneticsと血栓止血学2017
- Author(s)
  宮田敏行、坂野史明、田嶌優子、柳本広二、小亀浩市
- Organizer
  第39回日本血栓止血学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16K09834
[Presentation] 活性化プロテインC（APC）の臨床的用量が実験的脳梗塞の進展を抑制する2017
- Author(s)
  大和恵子、中城有香子、井本(山本)ひとみ、小亀浩市、宮田敏行、片岡大治、髙橋淳、柳本広二
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] A clinically relevant dose of activated protein C (APC) suppresses the development of experimental cerebral infarction2017
- Author(s)
  K. Yamato, Y. Nakajo, H. Yamamoto-Imoto, K. Kokame, T. Miyata, H. Kataoka, J.C. Takahashi, H. Yanamoto
- Organizer
  Neuroscience 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 稀な部位で静脈血栓症を発症した発端者を契機に遺伝子解析を行った先天性アンチトロンビン欠乏症タイプI家系の検討2017
- Author(s)
  根木玲子、伊田和史、光黒真菜、岡本章、小亀浩市、宮田敏行
- Organizer
  日本人類遺伝学会第62回大会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] Complete failure of integrin αIIbβ3 activation in kinetic assay associates with severe bleeding problems in a patient with kindlin-3 deficiency2017
- Author(s)
  H Kato, Y Ito, H Kashiwagi, Y Morikawa, K Akuta, N Nishiura, S Honda, K Kokame, T Miyata, Y Kanakura, Y Tomiyama
- Organizer
  The 26th Congress of the International Society on Thrombosis and Haemostasis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] 全ゲノム解析によりCFHR領域の新規融合遺伝子を認めたC3腎症例2017
- Author(s)
  菅原有佳、加藤秀樹、藤澤まどか、吉田瑶子、内田裕美子、小亀浩市、宮田敏行、秋岡祐子、三浦健一郎、服部元史、南学正臣
- Organizer
  第54回日本補体学会学術集会
- Data Source
  KAKENHI-PROJECT-17K07358
[Presentation] No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome2016
- Author(s)
  Toshiyuki Miyata, Yumiko Uchida, Yoko Yoshida, Hideki Kato, Masanori Matsumoto, Koichi Kokame, Yoshihiro Fujimura, Masaomi Nangaku
- Organizer
  XXVIth International Complement Workshop
- Place of Presentation
  金沢市
- Year and Date
  2016-09-04
- Data Source
  KAKENHI-PROJECT-16K09834
[Presentation] 先天性TTP／USSの遺伝子解析の現状2016
- Author(s)
  小亀浩市
- Organizer
  第10回日本血栓止血学会SSCシンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-02-20
- Invited
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Influence of a rotational speed modulation of an implantable continuous-flowleft ventricular assist device (EVAHEART) on von Willebrand factor dynamics2015
- Author(s)
  Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Minoru Ono, and Eisuke Tatsumi
- Organizer
  The 23rd Annual Meeting of the International Society for Rotary Blood Pumps (ISRBP)
- Place of Presentation
  Dubrovnik
- Year and Date
  2015-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Development of ELISA system for detection of protein S K196E mutation, a genetic risk factor for venous thromboembolism2015
- Author(s)
  Keiko Maruyama, Masashi Akiyama, Koichi Kokame, Akiko Sekiya, Eriko Morishita, and Toshiyuki Miyata
- Organizer
  XXV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Toronto
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 植え込み型補助人工心臓が血中von Willebrand factorに与える影響に関する研究2015
- Author(s)
  水野敏秀, 内藤敬嗣, 樋口（江浦）由佳, 小亀浩市, 宮田敏行, 築谷朋典, 武輪能明, 巽英介
- Organizer
  第53回人工臓器学会大会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 先天性TTP（USS）の分子診断2015
- Author(s)
  小亀浩市
- Organizer
  第9回日本血栓止血学会SSCシンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-02-28
- Invited
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] ADAMTS13 assays, the need for multicenter studies2015
- Author(s)
  Koichi Kokame, and Johanna A. Kremer Hovinga
- Organizer
  The 61th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  Toronto
- Year and Date
  2015-06-20
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 日本人の非典型溶血性尿毒症症候群患者の遺伝子解析補体系因子とDGKEの遺伝子変異2015
- Author(s)
  宮田敏行, 加藤秀樹, 内田裕美子, 吉田瑶子, 小亀浩市, 福岡利仁, 要伸也, 大田敏之, 浦山耕太郎, 藤永周一郎, 櫻谷浩志, 喜瀬智郎, 渡邉栄三, 織田成人, 永田裕子, 玉井宏史, 小松真太郎, 前沢浩司, 川村尚久, 永野幸治, 河野智康, 松本雅則, 藤村吉博, 南学正臣
- Organizer
  第52回日本補体学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2015-08-21
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 補助人工心臓装着による高分子量VWFマルチマーの減少は循環開始直後に始まる2015
- Author(s)
  樋口（江浦）由佳, 小亀浩市, 水野敏秀, 巽英介, 宮田敏行
- Organizer
  第37回日本血栓止血学会学術集会
- Place of Presentation
  甲府
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Hereditary TTP - a young patient population with high prevalence of arterial thromboembolic events: first results from the hereditary TTP registry2015
- Author(s)
  Magnus Mansouri, Masanori Matsumoto, Zuzana Cermakova, Kenneth D. Friedman, James N. George, Ingrid Hrachovinova, Paul N. Knobl, Koichi Kokame, Anne Sophie von Krogh, Reinhard Schneppenheim, Sara K. Vesley, Yoshihiro Fujimura, Bernhard Lammle, and Johanna A. Kremer Hovinga
- Organizer
  XXV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Toronto
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Characteristics and outcomes of patients with Upshaw-Schulman syndrome receiving maintenance hemodialysis due to chronic renal failure2015
- Author(s)
  Masanori Matsumoto, Ayami Isonishi, Koichi Kokame, Masaki Hayakawa, Hideo Yagi, Toshiyuki Miyata, and Yoshihiro Fujimura
- Organizer
  XXV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Toronto
- Year and Date
  2015-06-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 定常流型左室補助人工心臓に用いる自己心拍同期回転数制御システムがvon Willebrand factorに及ぼす影響2015
- Author(s)
  内藤敬嗣, 西村隆, 岸本諭, 水野敏秀, 武輪能明, 樋口（江浦）由佳, 小亀浩市, 宮田敏行, 小野稔, 巽英介
- Organizer
  第53回人工臓器学会大会
- Place of Presentation
  東京
- Year and Date
  2015-11-19
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 野生型プロテインＳおよびK196E変異体の発現精製と機能解析2015
- Author(s)
  丸山慶子, 小亀浩市, 秋山正志, 宮田敏行
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 妊娠を契機に診断された新規の遺伝子変異を伴うUpshaw-Schulman症候群（USS）の一例2013
- Author(s)
  小堺貴司，森山雅人，布施一郎，柴崎康彦，増子正義，瀧澤淳，鳥羽健，吉田邦彦，小亀浩市，宮田敏行，松本雅則，藤村吉博，曽根博仁
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Quantitative PCR-based analysis of ADAMTS13 genetic defects2013
- Author(s)
  Koichi Kokame
- Organizer
  The 59th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  Amsterdam, The Netherlands
- Invited
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013
- Author(s)
  小亀浩市，秋山正志，宮田敏行
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] A long-term phenotype analysis of 51 patients with Upshaw–Schulman syndrome in Japan, with special references to pregnancy and renal failure that requires hemodialysis2013
- Author(s)
  Yoshihiro Fujimura, Yumi Yoshii, Masanori Matsumoto, Ayami Isonishi, Hideo Yagi, Koichi Kokame, Toshiyuki Miyata
- Organizer
  55th American Society of Hematology Annual Meeting and Exposition
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] Quantitative PCR assay demonstrated exon deletions of ADAMTS13 in two unrelated patients with Upshaw-Schulman syndrome2013
- Author(s)
  Yuka Eura, Koichi Kokame, Toshiro Takafuta, Ryojiro Tanaka, Hikaru Kobayashi, Fumihiro Ishida, Shuichi Hisanaga, Masanori Matsumoto, Yoshihiro Fujimura, and Toshiyuki Miyata
- Organizer
  XXIV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用2013
- Author(s)
  土井政明，松井英人，竹田征治，斎藤能彦，武田麻衣子，松成泰典，西尾健治，嶋緑倫，坂野史明，秋山正志，小亀浩市，宮田敏行，杉本充彦
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 日本における先天性ADAMTS13欠損症の遺伝子解析2013
- Author(s)
  樋口（江浦）由佳，小亀浩市，松本雅則，藤村吉博，宮田敏行
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013
- Author(s)
  小亀浩市、秋山正志、宮田敏行
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] マウス急性心筋梗塞モデルにおけるADAMTS13の心筋保護作用2013
- Author(s)
  土井政明, 松井英人, 竹田征治, 斎藤能彦, 武田麻衣子, 松成泰典, 西尾健治, 嶋緑倫, 坂野史明, 秋山正志, 小亀浩市, 宮田敏行, 杉本充彦
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] Quantitative PCR-based analysis of ADAMTS13 genetic defects2013
- Author(s)
  Koichi Kokame
- Organizer
  The 59th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  Amsterdam, The Netherlands
- Invited
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] A long-term phenotype analysis of 51 patients with Upshaw–Schulman syndrome in Japan, with special references to pregnancy and renal failure that requires hemodialysis2013
- Author(s)
  Yoshihiro Fujimura, Yumi Yoshii, Masanori Matsumoto, Ayami Isonishi, Masaki Hayakawa, Yoko Yoshida, Hideo Yagi, Koichi Kokame, and Toshiyuki Miyata
- Organizer
  The 55th ASH Annual Meeting and Exposition
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Exacerbated venous thromboembolism in mice with the protein S Tokushima mutation2013
- Author(s)
  Fumiaki Banno, Toshiyuki Kita, Hiroji Yanamoto, Yuko Tashima, Koichi Kokame, and Toshiyuki Miyata
- Organizer
  XXIV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam, The Netherlands
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013
- Author(s)
  小亀浩市, 秋山正志, 宮田敏行
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] プロテインS徳島（PS-K196E）変異ノックインマウスの樹立と解析2013
- Author(s)
  坂野史明，喜多俊行，柳本広二，田嶌優子，小亀浩市，宮田敏行
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] 血栓性血小板減少性紫斑病患者のADAMTS13遺伝子に伏在していた変異の発見：ゲノムDNAを用いた定量PCR法の開発2013
- Author(s)
  樋口（江浦）由佳，小亀浩市，松本雅則，藤村吉博，宮田敏行
- Organizer
  第18回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  豊中
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] ADAMTS13の正常な分泌にはシクロフィリンBによるプロリン残基異性化が必要である2013
- Author(s)
  小亀浩市
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] 日本における先天性ADAMTS13欠損症の遺伝子解析2013
- Author(s)
  樋口（江浦）由佳, 小亀浩市, 松本雅則, 藤村吉博, 宮田敏行
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] Protective role of ADAMTS13 for myocardium in mouse model of experimental myocardial infarction2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
- Organizer
  54th American Society of Hematology, Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA.
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] 日本人の遺伝的血栓性リスクを有するモデルマウスの作製と解析2012
- Author(s)
  坂野史明・喜多俊行・柳本広二・小亀浩市・宮田敏行
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Protective Role of ADAMTS13 for Myocardium in Mouse Model of Experimental Myocardial Infarction.2012
- Author(s)
  Masaaki Doi, Hideto Matsui, Yukiji Takeda, Yoshihiko Saito, Maiko Takeda, Yasunori Matsunari, Kenji Nishio, Midori Shima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, and Mitsuhiko Sugimoto.
- Organizer
  2012 ASH Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Gene mutation analysis for Upshaw-Schulman syndrome.2012
- Author(s)
  Koichi Kokame.
- Organizer
  The 58th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  Liverpool, UK
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] 脳と心臓に特異的に発現する細胞内タンパク質NDRG4はNa^+/K^+-ATPase α3サブユニットに結合する2012
- Author(s)
  井本(山本)ひとみ・宮田敏行・小亀浩市
- Organizer
  第85回日本生化学会大会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] ADAMTS13 improving the cell engraftment efficacy in mouse model of bone marrow transplantation2012
- Author(s)
  Hideto Matsui, Masaaki Doi, Yasunori Matsunari, Maiko Takeda, Kenji Nishio, Midori Shima, Kenji Soejima, Fumiaki Banno, Masashi Akiyama, Koichi Kokame, Toshiyuki Miyata, Mitsuhiko Sugimoto.
- Organizer
  54th American Society of Hematology, Annual Meeting and Exposition
- Place of Presentation
  Atlanta, USA
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] Gene mutation analysis for Upshaw-Schulman syndrome2012
- Author(s)
  Koichi Kokame
- Organizer
  The 58th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  Liverpool, UK
- Invited
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Natural history of Upshaw-Schulman syndrome based on ADAMTS13 gene analysis in Japan.2011
- Author(s)
  Yoshihiro Fujimura, Masanori Matsumoto, Ayami Isonishi, Koichi Kokame, Kenji Soejima, Mitsuru Murata, and Toshiyuki Miyata.
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Findings from ADAMTS13 activity assay2011
- Author(s)
  Koichi Kokame
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  京都市
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4欠損マウスは,大脳皮質BDNF量の低下とともに,記憶学習能力の低下と局所脳虚血による梗塞巣の増大を示す2011
- Author(s)
  井本(山本)ひとみ・小亀浩市・奥田智彦・中城有香子・柳本広二・宮田敏行
- Organizer
  第9回血液・血管オルビス
- Place of Presentation
  東京
- Year and Date
  2011-08-20
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Estimation of the number of individuals with a congenital ADAMTS13 deficiency in Japan.2011
- Author(s)
  Koichi Kokame, Yoshihiro Kokubo, and Toshiyuki Miyata
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia with the decreased level of BDNF in the cortex.2011
- Author(s)
  Hitomi Yamamoto, Koichi Kokame, Tomohiko Okuda, Yukako Nakajo, Hiroji Yanamoto, and Toshiyuki Miyata
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Year and Date
  2011-07-28
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Estimation of the number of individuals with a congenital ADAMTS13 deficiency in Japan2011
- Author(s)
  Koichi Kokame, 他2名
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  京都市
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Generation of knock-in mice carrying a K196E point mutation in protein S.2011
- Author(s)
  Fumiaki Banno, Toshiyuki Kita, Hiroji Yanamoto, Koichi Kokame, Koji Iihara, and Toshiyuki Miyata
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Year and Date
  2011-07-27
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] NDRG4は大脳皮質中のBDNF量を正常に保ち,記憶学習能力の維持作用と虚血性脳卒中に対する脳保護作用を示す2011
- Author(s)
  井本(山本)ひとみ・小亀浩市・奥田智彦・中城有香子・柳本広二・宮田敏行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] ハイドロダイナミクス法によるin vivo遺伝子導入を用いたERAD基質の解析2011
- Author(s)
  樋口(江浦)由佳・宮田敏行・小亀浩市
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] ADAMTS13研究の最先端2011
- Author(s)
  宮田敏行・小亀浩市・秋山正志・武田壮一・坂野史明
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] シンポジウム6血栓止血学・血管生物学の最近の進歩、ADAMTS13研究の最先端2011
- Author(s)
  宮田敏行、小亀浩市、秋山正志、武田壮一、坂野史明
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-20390278
[Presentation] Findings from ADAMTS13 activity assay.2011
- Author(s)
  Koichi Kokame
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Kyoto
- Year and Date
  2011-07-25
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] P475S型ADAMTS13タンパク質の部分立体構造決定2011
- Author(s)
  秋山正志・中山大輔・武田壮一・小亀浩市・高木淳一・宮田敏行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] SATB1 induces early lymphocyte differentiation from primitive hematopoietic progenitors.2011
- Author(s)
  Yusuke Satoh, Takafumi Yokota, Hirokazu Tanaka, Koichi Kokame, Toshiyuki Miyata, Itaru Matsumura, Kenji Oritani, and Yuzuru Kanakura.
- Organizer
  第73回日本血液学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-15
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Roles of ERAD molecule Herp in the Parkinson' s disease (PD) models.2010
- Author(s)
  Hirofumi Sudo, Mika Takarada-Iemata, Koji Hashida, Koichi Kokame, Yasuko Kitao, Osamu Hori.
- Organizer
  第33回日本神経科学大会・第53回日本神経科学会大会・第20回日本神経回路学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Derlin-1 and Derlin-2 but not Derlin-3 deficient mice were embryonic lethal.2010
- Author(s)
  Yuka Eura, Yuji Arai, Toshiyuki Miyata, and Koichi Kokame.
- Organizer
  50th ASCB Annual Meeting, Philadelphia
- Place of Presentation
  USA
- Year and Date
  2010-12-14
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.(受賞講演)2010
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第33回日本血栓止血学会学術集会
- Place of Presentation
  鹿児島市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Fluorogenic and chromogenic assays of ADAMTS13 activity2010
- Author(s)
  Koichi Kokame
- Organizer
  The 56th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  エジプト・カイロ
- Year and Date
  2010-05-24
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Structure and function of TTP-related metalloprotease ADAMTS132010
- Author(s)
  Koichi Kokame
- Organizer
  The 6th Congress of Asia Pacific Society on Thrombosis and Haemostasis (APSTH 2010)
- Place of Presentation
  インドネシア・バリ
- Year and Date
  2010-10-25
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] 小胞体関連分解(ERAD)で機能する膜タンパク質Herpの欠損は耐糖能と虚血耐性の低下につながる2010
- Author(s)
  樋口(江浦)由佳・宮田敏行・小亀浩市
- Organizer
  第8回血液・血管オルビス
- Place of Presentation
  東京
- Year and Date
  2010-08-21
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] ADAMTS13の基準値と遺伝子多型2010
- Author(s)
  小亀浩市
- Organizer
  第7回日本血栓止血学会sscシンポジウーム
- Place of Presentation
  東京
- Year and Date
  2010-01-12
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] 脳虚血後の環境刺激による神経機能回復においてproBDNFの関与は小さい2010
- Author(s)
  平田健司・久下裕司・横田千晶・生野雄二・小亀浩市・原田晃名・半渾宏子・河嶋秀和・佐治英郎・峰松一夫・玉木長良
- Organizer
  第22回日本脳循環代謝学会総会
- Place of Presentation
  豊中
- Year and Date
  2010-11-26
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] 小胞体関連分解(ERAD)因子の発現量は臓器依存的に調節されておりDerlin-3欠損の影響を受ける2010
- Author(s)
  樋口(江浦)由佳・宮田敏行・小亀浩市
- Organizer
  第83回日本生化学会大会,第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2010-12-10
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Structure and function of TTP-related metalloprotease ADAMTS13.2010
- Author(s)
  Koichi Kokame
- Organizer
  The 6th Congress of Asia Pacific Society on Thrombosis and Haemostasis (APSTH 2010),
- Place of Presentation
  Bali, Indonesia
- Year and Date
  2010-10-15
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] Fluorogenic and chromogenic assays of ADAMTS13 activity.2010
- Author(s)
  Koichi Kokame
- Organizer
  The 56th Annual Scientific and Standardization Committee Meeting
- Place of Presentation
  Cairo, Egypt
- Year and Date
  2010-05-24
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第32回日本血栓止血学会学術総会
- Place of Presentation
  北九州市
- Year and Date
  2009-06-04
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] VWF切断酵素ADAMTS13と血栓性疾患2009
- Author(s)
  小亀浩市
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-20059039
[Presentation] ADAMTS13 assays.2009
- Author(s)
  Koichi Kokame
- Organizer
  The 55th Annual SSC Meeting
- Place of Presentation
  米国・ボストン
- Year and Date
  2009-07-12
- Data Source
  KAKENHI-PROJECT-20059039
[Presentation] X線解析によるADAMTS13の部分立体構造の決定とエキソサイトの同定(口演)2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第32回日本血栓止血学会学術集会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13と血栓症2009
- Author(s)
  小亀浩市
- Organizer
  第34回日本脳卒中学会総会
- Place of Presentation
  松江
- Year and Date
  2009-03-21
- Data Source
  KAKENHI-PROJECT-20059039
[Presentation] Crystal structure of the exosites-containing fragment of ADAMTS13.(口演、Abstract Symposia)2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  XXII Congress of the International Society on Thrombosis and Haemositasis
- Place of Presentation
  アメリカ・ボストン市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Crystal structre of the exosite-containing fragment of ADAMTS13.2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi T, Miyata T
- Organizer
  XXII Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  アメリカ・ボストン
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13によるVWFの認識機構2009
- Author(s)
  小亀浩市
- Organizer
  日本血栓止血学会SSCシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-20059039
[Presentation] ADAMTS13とVWF2009
- Author(s)
  小亀浩市
- Organizer
  第14回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  豊中
- Year and Date
  2009-08-21
- Data Source
  KAKENHI-PROJECT-20059039
[Presentation] ADAMTS13と血栓症2009
- Author(s)
  小亀浩市
- Organizer
  第34回日本脳卒中学会総会
- Place of Presentation
  松江
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定(ポスター)2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] ADAMTS13非触媒ドメインの結晶構造解析とvon Willebrand因子に対する複数の非連続エキソサイトの同定2009
- Author(s)
  秋山正志、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸市
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] Identification of multiple discontinuous exosites of ADAMTS13.(ポスター)2009
- Author(s)
  Akiyama M, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  The MMP Gordon Research Conference 2009
- Place of Presentation
  スイス・Les Diableret市
- Data Source
  KAKENHI-PROJECT-20570120
[Presentation] 一般住民を対象としたADAMTS13遺伝子の変異検索2008
- Author(s)
  小亀浩市
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2008-11-22
- Data Source
  KAKENHI-PROJECT-20059039
[Presentation] 一般住民を対象としたADAMTS13遺伝子の変異検索2008
- Author(s)
  小亀浩市
- Organizer
  第31回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] ADAMTS13 polymorphisms and rare mutations in the general population.2008
- Author(s)
  Koichi Kokame
- Organizer
  The 54th Annual SSC Meeting
- Place of Presentation
  オーストリア・ウィーン
- Year and Date
  2008-07-04
- Data Source
  KAKENHI-PROJECT-20059039
[Presentation] ADAMTS13 polymorphisms and rare mutations in the general population2008
- Author(s)
  Koichi Kokame
- Organizer
  The 54th Annual SSC Meeting
- Place of Presentation
  オーストリア
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] Binding of ADAMTS13 with Lys-plasminogen2008
- Author(s)
  Toshiyuki MIYATA, Yongchol SHIN, Koichi KOKAME, Masashi AKIYAMA, Kenji SOEJIMA
- Organizer
  Gordon Research Conference, Hemostasis 2008
- Place of Presentation
  Waterville Valley Resort, USA
- Data Source
  KAKENHI-PROJECT-20390278
[Presentation] Activities and polymorphisms of ADAMTS13 in the Japanese generalpopulation.2007
- Author(s)
  Koichi Kokame
- Organizer
  XXIst Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  ジュネーブ(スイス)
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] Measurements of ADAMTS13 activity, invited speaker2007
- Author(s)
  Koichi Kokame, Toshiyuki Miyata
- Organizer
  Subcommittee on vWF(and ADAMT13) at SSC meeting
- Place of Presentation
  Geneva
- Year and Date
  2007-07-06
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Presentation] 血栓性血小板減少性紫斑病とADAMTS132007
- Author(s)
  小亀浩市
- Organizer
  第8回Pharamaco-Hematologyシンポジウム
- Place of Presentation
  金沢
- Data Source
  KAKENHI-PROJECT-19570147
[Presentation] Effects of complete deficiency and C-terminal deletion of ADAMTS13 on hemostatic function in mice2007
- Author(s)
  Fumiaki Banno, Koichi Kokame, Tomohiko Okuda, Shigenori Honda, Shigeki Miyata, Hisashi Kato, Yoshiaki Tomiyama, Toshiyuki Miyata
- Organizer
  International Mammalian Genome Conference 2007
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390285
[Presentation] Analysis of mice carrying northeast Asian-specific genetic mutations in thrombosis
- Author(s)
  Fumiaki Banno, Yuko Tashima, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Koichi Kokame, Toshiyuki Miyata
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  都メッセ、京都府、京都市
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] ダイレクトシークエンシング，定量PCR，次世代シークエンシングを用いたTTP患者の遺伝子解析
- Author(s)
  樋口（江浦）由佳，小亀浩市，高蓋寿朗，田中亮二郎，小林光，石田文宏，久永修一，松本雅則，藤村吉博，宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] αIIb(R990W), a constitutive activating mutation of integrin αIIbβ3, knock-in mice show macrothrombocytopenia with impairment of platelet function
- Author(s)
  Kazunobu Kiyomizu, Hirokazu Kashiwagi, Shinji Kunishima, Fumiaki Banno, Hisashi Kato, Youichiro Morikawa, Seiji Tadokoro, Koichi Kokame, Shigenori Honda, Toshiyuki Miyata, Yuzuru Kanakura, Yoshiaki Tomiyama
- Organizer
  The 56th American Society of Hematology (ASH) Annual Meeting
- Place of Presentation
  San Francisco
- Year and Date
  2014-12-06 – 2014-12-09
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] デジタルPCRを用いたADAMTS13遺伝子変異のヘテロ接合性の解析
- Author(s)
  小亀浩市，樋口（江浦）由佳，松本雅則，藤村吉博，宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] インテグリンαIIbβ3活性化変異, αIIb(R990W)ノックインマウスの解析
- Author(s)
  清水一亘，柏木浩和，森川陽一郎，加藤恒，田所誠司，坂野史明，小亀浩市，本田繁則，金倉譲，宮田敏行，冨山佳昭
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] ダイレクトシークエンシング，定量PCR，次世代シークエンシングを用いたTTP患者の遺伝子解析
- Author(s)
  樋口(江浦)由佳、小亀浩市、高蓋寿朗、田中亮二郎、小林　光、石田文宏、久永修一、松本雅則、藤村吉博、宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター、大阪府、大阪市
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] ADAMTS13遺伝子欠損マウスの静脈血栓塞栓症状の解析
- Author(s)
  田嶌優子、坂野史明、小亀浩市、宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター、大阪府、大阪市
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] 深部静脈血栓症モデルを用いた日本人の血栓症モデルマウスの解析
- Author(s)
  坂野史明，田嶌優子，小亀浩市，宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] ADAMTS13の基準値と遺伝子多型
- Author(s)
  小亀浩市
- Organizer
  第7回日本血栓止血学会SSCシンポジウム
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22570151
[Presentation] デジタルPCRを用いたADAMTS13遺伝子変異ヘテロ接合性の解析
- Author(s)
  小亀浩市、樋口(江浦)由佳、松本雅則、藤村吉博、宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター、大阪府、大阪市
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] プロテインS K196E（PS徳島）変異検出ELISA法の開発
- Author(s)
  丸山慶子，秋山正志，小亀浩市，森下英理子，宮田敏行
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Structural basis for ADAMTS13 function.
- Author(s)
  Akiyama M, Nakayama D, Takeda S, Kokame K, Takagi J, Miyata T
- Organizer
  XXIII Congress of the International Society on Thrombosis and Haemositasis
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] HUVECにおけるレスベラトロールによるeNOS、SIRT1、オートファジー関連遺伝子の発現誘導
- Author(s)
  滝澤祥恵，小菅由希子，淡路比呂代，田村恵美，高井綾子，矢内隆章，山本玲子，小亀浩市，宮田敏行，井上裕康
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] Analysis of mice carrying northeast Asian-specific genetic mutations in thrombosis
- Author(s)
  Fumiaki Banno, Yuko Tashima, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Kochi Kokame, Toshiyuki Miyata
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  Kyoto
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] プロテインS K196E (PS徳島)変異特異的ELISA法の構築、Construction of ELISA system for specific detection of protein S K196E (PS Tokushima) mutation
- Author(s)
  Keiko Maruyama, Masashi Akiyama, Koichi Kokame, Eriko Morishita, Toshiyuki Miyata
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪国際会議場、大阪府、大阪市
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24390250
[Presentation] P475S型ADAMTS13タンパク質の部分立体構造決定」（ポスター）第84回日本生化学会大会
- Author(s)
  秋山正志、中山大輔、武田壮一、小亀浩市、高木淳一、宮田敏行
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23570155
[Presentation] VWF切断酵素ADAMTS13の基礎知識
- Author(s)
  小亀浩市
- Organizer
  第62回日本輸血・細胞治療学会総会
- Place of Presentation
  奈良
- Year and Date
  2014-05-15 – 2014-05-17
- Invited
- Data Source
  KAKENHI-PROJECT-25440060
[Presentation] TTP患者の遺伝子解析
- Author(s)
  小亀浩市
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-05-29 – 2014-05-31
- Invited
- Data Source
  KAKENHI-PROJECT-25440060

1. MIYATA Toshiyuki (90183970)

# of Collaborated Projects: 16 results

# of Collaborated Products: 61 results
2. AKIYAMA Masashi (30298179)

# of Collaborated Projects: 9 results

# of Collaborated Products: 37 results
3. BANNO Fumiaki (00373514)

# of Collaborated Projects: 5 results

# of Collaborated Products: 14 results
4. EURA Yuka (30443477)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
5. TAKEDA Soichi (80332279)

# of Collaborated Projects: 3 results

# of Collaborated Products: 21 results
6. IMOTO Hitomi (50532230)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. HINE Chiemi (10280819)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KATO Hisao (80029959)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. MIYATA Shigeki (20239411)

# of Collaborated Projects: 2 results

# of Collaborated Products: 12 results
10. Maruyama Keiko (30712624)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. SADLER J.Evan

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. OKADA Hiromi (00426503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. MATSUMOTO Sachiko (80463272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KITA Toshiyuki (70589986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. SAKATA Toshiyuki (80531029)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. OKAMOTO Akira (10531030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. OKUDA Tomohiko (90360817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. HONDA Shigenori (00303959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
19. Yokota Chiaki (80300979)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KODAKA MITSUHARU (90280635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 吉松淳 (20221674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 天滿敬 (90378787)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 越野一博 (90393206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 安野史彦 (60373388)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 根木玲子 (90600594)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
26. 辻明宏 (70598367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
27. 関根章博 (30425631)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. 松浦功泰 (50880944)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 田中綾 (70334480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 武居昌宏 (90277385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. Ando Daisuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. FAN Xinping

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. EVAN Sadler

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. LENTS Steven

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. Ikejima Hiroko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. SHIN Yongchol

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. SATOH Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. TAKARADA Mika

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 松本雅則

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
40. 藤村吉博

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
41. 深田吉孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 藤原亨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 三好剛一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 森下英理子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 織谷健司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 金倉譲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 堀修

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
48. 吉田瑶子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 和田英夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

KOKAME KOICHI 小亀 浩市

KOKAME Koichi 小亀 浩市

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止血タンパク質の発現多様性と止血機能および止血以外の機能に関する基礎研究Principal Investigator

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Study on endoplasmic reticulum-associated degradation (ERAD) dysfunction causing lethal effects in hypoxiaPrincipal Investigator

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Quality control of secretory proteins containing proline residues in the cis formPrincipal Investigator

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Molecular and physiological functions of NDRG1 and NDRG4Principal Investigator

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小胞体関連分解を担うタンパク質複合体の全容解明とその標的タンパク質の同定Principal Investigator

KOKAME KOICHI 小亀浩市

KOKAME Koichi 小亀浩市