Mitsuhashi Akira 三橋暁

… Alternative Names

MITSUHASHI Akira 三橋暁

三橋暁ミツハシアキラ

三橋曉ミツハシアキラ

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Researcher Number	40302541
Other IDs
External Links
Affiliation (Current)	2025: 獨協医科大学, 医学部, 教授 2025: 千葉大学, 大学院医学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2020 – 2021: 千葉大学, 大学院医学研究院, 特任教授 2019: 千葉大学, 大学院医学研究院, 准教授 2016 – 2017: 千葉大学, 大学院医学研究院, 准教授 2012 – 2015: 千葉大学, 医学(系)研究科(研究院), 准教授 2012: 千葉大学, 医学研究科(研究院), 准教授 … More 2009 – 2011: Chiba University, 大学院・医学研究院, 准教授 2007 – 2008: Chiba University, Department of Reproductive Medicine, Lecture 2007: 千葉大学, 大学院・医学系研究科, 講師 2006: 千葉大学, 大学院医学研究院, 講師 2004: 千葉大学, 大学院・医学研究院, 助手 2003: 千葉大学, 医学部附属病院, 助手 2000 – 2001: 千葉大学, 医学部・附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator メトホルミン / 子宮体癌 / インスリン抵抗性 / 肥満 / 子宮内膜癌 / 子宮頸部癌 / 酸化的リン酸化阻害剤 / 糖代謝 / sgRNAスクリーニング / 癌代謝 … More / メチル化 / 婦人科腫瘍学 / ホモ欠失 / 3p21.3 / 子宮頸癌 / LOH / 3p21.3ホモ欠失 / HPV negative / cervical cancer / EGFR / HPV … More Except Principal Investigator ovulation induction / endometriosis / uterine leiomyoma / inhibitor / aromatase / 脂肪 / 妊孕性 / 排卵障害 / 催奇形性 / 排卵誘発 / 子宮内膜症 / 子宮筋腫 / 活性阻害剤 / アロマターゼ / GAMMA-CATENIN / BETA-CATENIN / GRNE EXPRESSION / CULTURED CELL / GENE AMPLIFICATION / CHROMOSOME 3 / OVARIAN CANCER / γ-catenin / β-catenin / 遺伝子発現 / 培養細胞 / 遺伝子増幅 / 第三染色体 / 卵巣癌 / 動物実験モデル / NOGマウス / 腎被膜下移植 / エストロゲン / 子宮内膜癌 Less

Elucidation of abnormal metabolic profile of endometrial cancerPrincipal Investigator
- Principal Investigator
  
  Mitsuhashi Akira
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Chiba University
Clinical study of endometrial cancer prevention by metformin: targeting obesity and insulin resistancePrincipal Investigator
- Principal Investigator
  
  Mitsuhashi Akira
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Chiba University
Chemoprevention of endometrial cancer by metfomrinPrincipal Investigator
- Principal Investigator
  
  MITSUHASHI Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Chiba University
Construction of xenograft models of human endometrial cancer in NOD/SCID IL-2R gamma null mice
- Principal Investigator
  
  KATO Kazuyoshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  公益財団法人がん研究会
   Chiba University
To investigate of anti-neoplastic effect of metformin in endometrial cancerPrincipal Investigator
- Principal Investigator
  
  MITSUHASHI Akira
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Chiba University
Study of PAX2 promoter methylation status in the carcinogenesis of estrogen dependent endometrial cancerPrincipal Investigator
- Principal Investigator
  
  MITSUHASHI Akira
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Chiba University
Basic and Clinical study on endocrine therapy of gynecologic diseases targeting aromatase
- Principal Investigator
  
  SHOZU Makio
- Project Period (FY)
  2004 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Chiba University
  Kanazawa University
子宮頸部癌における3p21.3領域のホモ欠失の検索Principal Investigator
- Principal Investigator
  
  三橋暁
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Chiba University
HPV陰性子宮頸部癌の発癌機構の解明Principal Investigator
- Principal Investigator
  
  三橋暁 (三橋曉)
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Chiba University
MOLECULAR MECHANISM INVOLVED IN ONCOGENESIS AND PROGRESSION OF OVARIAN CANCER
- Principal Investigator
  
  TANAKA Naotake
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  CHIBA UNIVERSITY

[Journal Article] Lymphadenectomy issues in endometrial cancer.2021
- Author(s)
  Konno Y, Asano H, Shikama A, Aoki D, Tanikawa M, Oki A, Horie K, Mitsuhashi A, Kikuchi A, Tokunaga H, Terao Y, Satoh T, Ushijima K, Ishikawa M, Yaegashi N, Watari H.
- Journal Title
  
  J Gynecol Oncol
  
  Volume: 32 Issue: 2
- DOI
  10.3802/jgo.2021.32.e25
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09796
[Journal Article] High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast‐enhanced CT using D‐dimer as an index2021
- Author(s)
  Habu Yuji、Mitsuhashi Akira、Hanawa Shinsuke、Usui Hirokazu、Horikoshi Takuro、Uno Takashi、Shozu Makio
- Journal Title
  
  Journal of Surgical Oncology
  
  Volume: 124 Issue: 1 Pages: 106-114
- DOI
  10.1002/jso.26471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09796
[Journal Article] Time-lapse monitoring of fertilized human oocytes focused on the incidence of 0PN embryos in conventional in vitro fertilization cycles. Kobayashi T, Ishikawa H, Ishii K, Sato A, Nakamura N, Saito Y, Hasegawa H, Fujita M, Mitsuhashi A, Shozu M.2021
- Author(s)
  Kobayashi T, Ishikawa H, Ishii K, Sato A, Nakamura N, Saito Y, Hasegawa H, Fujita M, Mitsuhashi A, Shozu M.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 18862-18862
- DOI
  10.1038/s41598-021-98312-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09748, KAKENHI-PROJECT-19K09796, KAKENHI-PROJECT-19K18663
[Journal Article] Medroxyprogesterone acetate plus metformin for fertility-sparing treatment of atypical endometrial hyperplasia and endometrial carcinoma: trial protocol for a prospective, randomised, open, blinded-endpoint design, dose-response trial (FELICIA trial)2020
- Author(s)
  Mitsuhashi Akira、Kawasaki Yohei、Hori Makoto、Fujiwara Tadami、Hanaoka Hideki、Shozu Makio
- Journal Title
  
  BMJ Open
  
  Volume: 10 Issue: 2 Pages: e035416-e035416
- DOI
  10.1136/bmjopen-2019-035416
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09796
[Journal Article] New therapeutic approaches for the fertility-sparing treatment of endometrial cancer2020
- Author(s)
  Mitsuhashi Akira、Shozu Makio
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 46 Issue: 2 Pages: 215-222
- DOI
  10.1111/jog.14155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09796
[Journal Article] Development of localized cul-de-sac endometrioid carcinoma associated with deep infiltrating endometriosis during remission of early endometrial cancer2020
- Author(s)
  Seki Kumiko、Ishikawa Hiroshi、Hashimoto Rei、Mitsuhashi Akira、Ikeda Jun-ichiro、Shozu Makio
- Journal Title
  
  Gynecologic Oncology Reports
  
  Volume: 31 Pages: 100526-100526
- DOI
  10.1016/j.gore.2019.100526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09796
[Journal Article] Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy.2020
- Author(s)
  Takekuma M, Takahashi F, Mabuchi S, Kudaka W, Horie K, Ikeda M, Shikama A, Mitsuhashi A, Nagao S, Suzuki S, Mizuno M, Nishio S, Tokunaga H, Ota Y, Kasamatsu T, Kitagawa R, Toita T, Kobayashi H, Ishikawa M, Yaegashi N.
- Journal Title
  
  BMC Cancer
  
  Volume: 20 Issue: 1 Pages: 1169-1169
- DOI
  10.1186/s12885-020-07672-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08179, KAKENHI-PROJECT-19K09796
[Journal Article] Long-term outcomes of progestin plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer patients2019
- Author(s)
  Mitsuhashi Akira、Habu Yuji、Kobayashi Tatsuya、Kawarai Yoshimasa、Ishikawa Hiroshi、Usui Hirokazu、Shozu Makio
- Journal Title
  
  Journal of Gynecologic Oncology
  
  Volume: 30 Issue: 6 Pages: 1-11
- DOI
  10.3802/jgo.2019.30.e90
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09281, KAKENHI-PROJECT-19K09796
[Journal Article] Antitumor effects of metformin via indirect inhibition of protein phosphatase 2A in patients with endometrial cancer.2018
- Author(s)
  Hanawa S, Mitsuhashi A, Shozu M.
- Journal Title
  
  PLoS One
  
  Volume: 13 Issue: 2 Pages: e0192759-e0192759
- DOI
  10.1371/journal.pone.0192759
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10702
[Journal Article] Metformin alters DNA methylation genome-wide via the H19/SAHH axis.2017
- Author(s)
  Zhong T, Men Y, Lu L, Geng T, Zhou J, Mitsuhashi A, Shozu M, Maihle NJ, Carmichael GG, Taylor HS, Huang Y.
- Journal Title
  
  Oncogene
  
  Volume: 36 Issue: 17 Pages: 2345-2354
- DOI
  10.1038/onc.2016.391
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10702
[Journal Article] Prospective evaluation of abnormal glucose metabolism and insulin resistance in patients with atypical endometrial hyperplasia and endometrial cancer.2017
- Author(s)
  Mitsuhashi A, Uehara T, Hanawa S, Shozu M.
- Journal Title
  
  Support Care Cancer.
  
  Volume: 25 Issue: 5 Pages: 1495-1501
- DOI
  10.1007/s00520-016-3554-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10702
[Journal Article] Phase II study of medroxyprogesterone acetate plus metformin as a fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer2016
- Author(s)
  Mitsuhashi A
- Journal Title
  
  Ann Oncol
  
  Volume: 27 Issue: 2 Pages: 262-266
- DOI
  10.1093/annonc/mdv539
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10702
[Journal Article] Metformin potentiates the anticancer effects of cisplatin under normoxic conditions in vitro2015
- Author(s)
  TAKASHI UEHARA, AKIRA MITSUHASHI, NOBUHIDE TSURUOKA, MAKIO SHOZU1
- Journal Title
  
  ONCOLOGY REPORTS
  
  Volume: 33 Issue: 2 Pages: 744-750
- DOI
  10.3892/or.2014.3611
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592504, KAKENHI-PROJECT-25670694
[Journal Article] 糖尿病治療薬メトホルミンが子宮体がんに奏効する可能性2015
- Author(s)
  三橋暁
- Journal Title
  
  産科と婦人科
  
  Volume: 82
- Data Source
  KAKENHI-PROJECT-24592504
[Journal Article] 特集/婦人科悪性腫瘍治療に対するドラッグリポジショニングの幕開け -既存薬に秘められた新たな可能性- 4.糖尿病治療薬メトホルミンが子宮体がんに奏効する可能性2015
- Author(s)
  三橋　暁
- Journal Title
  
  産科と婦人科
  
  Volume: 82 Pages: 1099-1105
- Data Source
  KAKENHI-PROJECT-15K10702
[Journal Article] Effects of metformin on endometrial cancer cell growth in vivo: a preoperative prospective trial2014
- Author(s)
  Akira Mitsuhashi, Takako Kiyokawa, Yasunori Sato, Makio Shozu
- Journal Title
  
  Cancer
  
  Volume: 120 Issue: 19 Pages: 2986-2995
- DOI
  10.1002/cncr.28853
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592504, KAKENHI-PROJECT-25670694
[Journal Article] 子宮体がんでの妊孕性温存療法の新たな展開2013
- Author(s)
  三橋　暁
- Journal Title
  
  産婦人科の実際
  
  Volume: 62 Pages: 1207-1213
- Data Source
  KAKENHI-PROJECT-24592504
[Journal Article] 子宮体がんの妊孕性温存療法2013
- Author(s)
  三橋　暁
- Journal Title
  
  臨床婦人科産科
  
  Volume: 67 Pages: 498-504
- Data Source
  KAKENHI-PROJECT-24592504
[Journal Article] Daily Low-Dose Cisplatin-Based Concurrent Chemoradiotherapy in Patients With Uterine Cervical Cancer With Emphasis on Elderly Patients: A Phase 2 Trial2012
- Author(s)
  Mitsuhashi A, Uno T, Usui H, Nishikimi K, Yamamoto N, Watanabe M, Tate S, Hirashiki K, Kato K, Yamazawa K, Shozu M
- Journal Title
  
  Int J Gynecol Cancer
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591847
[Journal Article] The application of a newly developed linear stapler preloaded with the tissue reinforcement to distal pancreatectomy in the management of ovarian cancer2011
- Author(s)
  Kazuyoshi Kato, Shinichi Tate, Takashi Uehara, Hirokazu Usui, Akira Mitsuhashi, Makio Shozu
- Journal Title
  
  European Journal of Gynaecological Oncology
  
  Volume: 32 Pages: 579-581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591847
[Journal Article] The application of a newly developed linear stapler preloaded with the tissue reinforcement to distal pancreatectomy in the management of ovarian cancer2011
- Author(s)
  Kazuyoshi Kato, Shinichi Tate, Takashi Uehara, Hirokazu Usui, Akira Mitsuhashi, Makio Shozu
- Journal Title
  
  Eur J Gynaecol Oncol
  
  Volume: 32 Pages: 579-581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591847
[Journal Article] Postoperative concurrent daily low-dose cisplatin-based chemoradiation improves the prognosis of patients with pathologic T2b or N1 cervical cancer2010
- Author(s)
  Mitsuhashi A, Uno T, Usui H, Tate S, Hirashiki K, Kato K, Kiyohara H, Kato S, Ito H, Shozu M
- Journal Title
  
  Anticancer Res
  
  Volume: 30 Pages: 2341-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591847
[Journal Article] Primary synovial sarcoma in fallopian tube : case report and literature review.2007
- Author(s)
  Mitsuhashi A, Nagai Y, Suzuka K, Yamazawa K, Nojima T, Nikaido T, Ishikura H, Matsui H, Shozu M.
- Journal Title
  
  Int J Gynecol Pathol. 26・1
  
  Pages: 34-7
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Journal Article] Primary synovial sarcoma in fallopian tube: case report and literature review.2007
- Author(s)
  Mitsuhashi A, Nagai Y, Suzuka K, Yamazawa K, Nojima T, Nikaido T, Ishikura H, Matsui H, Shozu M.
- Journal Title
  
  Int J Gynecol Pathol. 26(1)
  
  Pages: 34-7
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Journal Article] 排卵誘発剤としてのアロマターゼ阻害剤2007
- Author(s)
  生水真紀夫, 碓井宏和, 三橋暁, 松井英雄
- Journal Title
  
  産科と婦人科 74・8
  
  Pages: 929-937
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Journal Article] An aromatase inhibitor as an ovulation induction drug.2007
- Author(s)
  Shozu M, Usui H, Mitsuhashi A, Matsui H.
- Journal Title
  
  Obstet gynecol. 74(8)
  
  Pages: 929-937
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Journal Article] 排卵誘発剤としてのアロマターゼ阻害剤2007
- Author(s)
  生水真紀夫, 碓井宏和, 三橋暁, 松井英雄
- Journal Title
  
  産科と婦人科 74
  
  Pages: 929-937
- Data Source
  KAKENHI-PROJECT-16209049
[Journal Article] Primary synovial sarcoma in fallopian tube:case report and literature revlew.2007Jan;26(1):34-7.Review.2007
- Author(s)
  Mitsuhashi A, Nagai Y, Suzuka K, Yamazawa K, Nojima T, Nikaido T, lshikura H, Matsui H, Shozu M.
- Journal Title
  
  Int J Gynecol Pathol 26
  
  Pages: 34-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16209049
[Journal Article] 子宮内膜症のスクリーニング2006
- Author(s)
  生水真紀夫, 山澤功二, 三橋暁, 確井宏和, 木原真紀
- Journal Title
  
  産婦人科の実際 55(11)
  
  Pages: 1894-1897
- Data Source
  KAKENHI-PROJECT-16209049
[Presentation] Metformin may attenuate the effect of hyperprolactinemia induced by medroxyprogesterone acetate during fertility-sparing treatment for patients with atypical endometrial hyperplasia and endometrial cancer2019
- Author(s)
  Mitsuhashi A, Gu W, Habu Y, Kobayashi T, Shozu M.
- Organizer
  ESGO 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09796
[Presentation] Antitumor effects of metformin via indirect inhibition of protein phosphatase PP2A in patients with endometrial cancer2016
- Author(s)
  Shinsuke Hanawa, Akira Mitsuhashi, Makio Shozu
- Organizer
  16th Biennial Meeting of the International Gynecologic Cancer Society (IGCS)
- Place of Presentation
  Lisbon,Portugal
- Year and Date
  2016-10-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10702
[Presentation] 子宮体癌に対するメトホルミン療法の応用2016
- Author(s)
  三橋　暁
- Organizer
  第16回関東ホルモンと癌研究会
- Place of Presentation
  東京大学医科学研究所附属病院（東京都港区)
- Year and Date
  2016-01-30
- Data Source
  KAKENHI-PROJECT-15K10702
[Presentation] メトホルミン投与はインスリン抵抗性を有する患者で子宮体癌組織のPP2A発現を抑制する2016
- Author(s)
  塙伸輔、三橋暁、生水真紀夫
- Organizer
  日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K10702
[Presentation] 子宮体癌組織のPP2Aの発現はメトホルミン投与で抑制される2016
- Author(s)
  塙伸輔、三橋暁、生水真紀夫
- Organizer
  日本婦人科腫瘍学会学術講演会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-07-08
- Data Source
  KAKENHI-PROJECT-15K10702
[Presentation] 子宮体癌に対するメドロキシプロゲステロン＋メトホルミン併用妊孕性温存療法の臨床第2相試験2016
- Author(s)
  三橋暁、塙伸輔、碓井宏和、生水真紀夫
- Organizer
  日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-15K10702
[Presentation] メトホルミンは間接的に子宮内膜癌患者の増殖を抑制する2013
- Author(s)
  三橋　暁
- Organizer
  第14回ホルモンと癌研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] メトホルミンは単独および抗がん薬との併用で子宮体癌細胞の増殖を抑制する2013
- Author(s)
  植原　貴史、三橋　暁
- Organizer
  第65回日本産科婦人科学会　学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] メトホルミンは間接的に子宮内膜癌患者の増殖を抑制する2013
- Author(s)
  三橋　暁
- Organizer
  第65回日本産科婦人科学会　学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] メトホルミンは間接的に子宮内膜癌患者の増殖を抑制する2013
- Author(s)
  三橋　暁
- Organizer
  第54回　日本婦人科腫瘍学会学術講演会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] Metformin prevents recurrence of endometrial cancer or atypical endometrial hyperplasia after progestin therapy and improves insulin resistance for fertility-sparing treatment in young women.2012
- Author(s)
  A Mitsuhashi et al.
- Organizer
  15th ICHSHC
- Place of Presentation
  Kanazawa, Japan
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] 低濃度メトフォルミンは、抗がん薬との併用で子宮体癌細胞に対し、相乗相加効果は示さない2012
- Author(s)
  植原貴史, 三橋暁, 他
- Organizer
  第12回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2012-01-19
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌・子宮内膜異型増殖症に対するメドロキシプロゲステロン＋メトホルミン併用妊孕性温存療法の前方視的試験.2012
- Author(s)
  三橋　暁
- Organizer
  第52回日本婦人科腫瘍学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] Therapeutic doses of metformin suppresses cell proliferation of endometrial cancer in vivo.2012
- Author(s)
  A Mitsuhashi et al.
- Organizer
  14th IGCS
- Place of Presentation
  Vancouver ,Canada
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験2011
- Author(s)
  三橋暁, 他
- Organizer
  第50回婦人科腫瘍学会
- Place of Presentation
  札幌
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] SURGICAL ANATOMY OF THE VAGINAL AND INFERIOR VESICAL ARTERIES IN NERVE-SPARING RADICAL HYSTERECTOMY2011
- Author(s)
  Kazuyoshi Kato, K.Nishikimi, H.Usui, S.Tate, N.Yamamoto, K.Yamazawa, Akira Mitsuhashi, Makio Shozu
- Organizer
  17th International Meeting Of The European Society Of Gynaecological Oncology
- Place of Presentation
  Milan Convention Center(イタリアミラノ)
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-22591847
[Presentation] The effect of metformin on cell proliferation in patients with endometrial cancer2011
- Author(s)
  Akira Mitsuhashi, et al
- Organizer
  2011 ASCO Annual Meeting
- Place of Presentation
  アメリカ・シカゴ
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 骨盤自律神経温存広汎子宮全摘術における下膀胱動脈の臨床解剖学的検討2011
- Author(s)
  加藤一喜、錦見恭子、三橋暁、生水真紀夫, 他
- Organizer
  第50回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2011-07-24
- Data Source
  KAKENHI-PROJECT-22591847
[Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験2011
- Author(s)
  三橋暁, 他
- Organizer
  第12回ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] The effect of metformin on cell proliferation in patients with endometrial cancer2011
- Author(s)
  三橋暁
- Organizer
  2011 ASCO Annual Meeting
- Place of Presentation
  シカゴ(招待講演)
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験2011
- Author(s)
  三橋暁
- Organizer
  第12回ホルモンと癌研究会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-07-15
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] Metformin prevents recurrence following discontinuation of progestin therapy for fertility-sparing treatment in young women with endometrial cancer or atypical endometrial hyperplasia2011
- Author(s)
  三橋暁
- Organizer
  The 17^<th> International Meeting of the European Society of Gynecological Oncology (ESGO)
- Place of Presentation
  ミラノ(招待講演)
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] Metformin prevents recurrence following discontinuation of progestin therapy for fertility-sparing treatment in young women with endometrial cancer or atypical endometrial hyperplasia2011
- Author(s)
  Akira Mitsuhashi, et al
- Organizer
  The 17^<th> International Meeting of the European Society of Gynecological Oncology
- Place of Presentation
  (ESGO)(イタリア・ミラノ)
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験2011
- Author(s)
  三橋暁, 他
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2011-08-29
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌に対する内分泌療法2011
- Author(s)
  三橋暁, 他
- Organizer
  第11回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2011-01-29
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験2011
- Author(s)
  三橋暁
- Organizer
  第50回婦人科腫瘍学会
- Place of Presentation
  札幌(招待講演)
- Year and Date
  2011-07-22
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌に対するメドロキシプロゲステロン+メトホルミン併用妊孕性温存療法の前方視的試験2011
- Author(s)
  三橋暁
- Organizer
  第63回日本産科婦人科学会
- Place of Presentation
  大阪(招待講演)
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮内膜癌に対するメトホルミンの抗腫瘍効果とその機序の検討2010
- Author(s)
  三橋暁
- Organizer
  婦人科腫瘍学会
- Place of Presentation
  筑波
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮内膜癌に対するメトホルミンの抗腫瘍効果とその機序の検討2010
- Author(s)
  三橋暁, 他
- Organizer
  第48回婦人科腫瘍学会
- Place of Presentation
  札幌
- Year and Date
  2010-07-22
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] Metformin directly inhibits cell proliferation in endometrial cancer2010
- Author(s)
  Akira Mitsuhashi
- Organizer
  14^<th> international congress of Hormonal Steroid and Hormones&Cancer
- Place of Presentation
  エジンバラ
- Year and Date
  2010-09-23
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌に対するメトホルミンの効果:作用機序の検討と臨床応用2010
- Author(s)
  三橋暁, 他
- Organizer
  第11回ホルモンと癌研究会
- Place of Presentation
  名古屋
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] 子宮体癌に対するメトホルミンの効果:臨床応用と作用機序の検討2010
- Author(s)
  三橋暁
- Organizer
  第10回関東ホルモンと癌研究会
- Place of Presentation
  東京
- Year and Date
  2010-01-23
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] Metformin directly inhibits cell proliferation in endometrial cancer2010
- Author(s)
  Akira Mitsuhashi, et al
- Organizer
  14^<th> international congress of Hormonal Steroid and Hormones & Cancer
- Place of Presentation
  イギリス・エジンバラ
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-21592123
[Presentation] The measurements of serum human chorionic gonado tropin (HCG) in patients with gestational trophoblastic neoplasia (GTN) using eith two different commercial Hgg kits.2007
- Author(s)
  Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakada, Shinnichi Tate, Akira Mitsuhashi, Makio Shozu
- Organizer
  The 14^<th> World Congress on Gestational Trophoblastic Diseases.
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Presentation] Protease profile of conditioned medium from choriocarcinoma cell lines.2007
- Author(s)
  H. Usui, H. Matsui, A Mitsuhashi, M Kihara, B batzoring, E. Nakada, M. shozu
- Organizer
  The 14^<th> World Congress on Gestaional Trophoblastic Diseases
- Place of Presentation
  Fukouka
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Presentation] Protease profile of conditioned medium from choriocarcinoma cell lines.2007
- Author(s)
  H. Usui, H. Matsui, A. Mitsuhashi, M. Kihara, B. Batzorig, E. Nakada, M. Shozu
- Organizer
  The 14^<th>World Congress on Gestational Trophoblastic Diseases
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Presentation] The measurements of serum human chorionic gonadotropin (hCG) in patients with gestational trophoblastic neoplasia (GTN) using eith two different commercial hCG kits.2007
- Author(s)
  Hideo Matsui, Maki Kihara, Hirokazu Usui, Emiri Nakada, Shinnichi Tate, Akira Mitsuhashi, Makio Shozu.
- Organizer
  The 14^<th>World Congress on Gestational Trophoblastic Diseases
- Place of Presentation
  Fukuoka
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16209049
[Presentation] A phase II study of medroxyprogesterone acetate plus metformin as fertility-sparing treatment for atypical endometrial hyperplasia and endometrial cancer.
- Author(s)
  Mitsuhashi, A. Usui, H. Satoh, Y. Kiyokawa, T. Shozu, M.
- Organizer
  ASCO2014
- Place of Presentation
  CHIKAGO（USA）
- Year and Date
  2014-05-30 – 2014-06-03
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] Prospective evaluation of glucose tolerance and insulin resistance among patients with endometrial cancer and atypical endometrial hyperplasia
- Author(s)
  Mitsuhashi, A. Hanawa, S. Yamamoto, N. Uehara, T. Nishikimi, K. Tate, S. Usui, H. Shozu, M.
- Organizer
  ESMO2014
- Place of Presentation
  バルセロナ（スペイン）
- Year and Date
  2014-09-26 – 2014-09-30
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] メトホルミンはインスリン抵抗性改善による間接効果で子宮内膜癌の増殖を抑制する
- Author(s)
  三橋　暁
- Organizer
  第88回日本内分泌学会
- Place of Presentation
  ホテルニューオータニ東京（東京都千代田区）
- Year and Date
  2015-04-23 – 2015-04-25
- Data Source
  KAKENHI-PROJECT-24592504
[Presentation] Prospective evaluation of abnormal glucose metabolism and insulin resistance among patients with endometrial cancer and atypical endometrial hyperplasia
- Author(s)
  Akira Mitsuhashi, Shinsuke Hanawa, Noriko Yamamoto, Takashi Uehara, Kyoko Nishikimi, Shinichi Tate, Hirokazu Usui, Makio Shozu
- Organizer
  第66回日本産科婦人科学会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592504
[]

1. SHOZU Makio (30226302)

# of Collaborated Projects: 6 results

# of Collaborated Products: 30 results
2. USUI Hirokazu (90375634)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. KATO Kazuyoshi (80399451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. ISHIKAWA Hiroshi (70553973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. NISHIKIMI Kyoko (00536302)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. YAMAMOTO Noriko (30586722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. TANAKA Naotake (80236611)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SEKIYA Souei (00092065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. INOUE Masaki (10127186)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KIHARA Maki (20375760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. MURAKAMI Koichi (20242555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 海野洋一 (90375759)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 小野俊介 (40345591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 植原貴史 (70568659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. 羽生裕二 (40816162)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 安西尚彦 (70276054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KOBAYASHI Tatsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. TOITA Takahumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mitsuhashi Akira 三橋 暁

MITSUHASHI Akira 三橋 暁

三橋 暁 ミツハシ アキラ

三橋 曉 ミツハシ アキラ

Research Projects

Research Products

Co-Researchers

Elucidation of abnormal metabolic profile of endometrial cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical study of endometrial cancer prevention by metformin: targeting obesity and insulin resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Chemoprevention of endometrial cancer by metfomrinPrincipal Investigator

Principal Investigator

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Research Institution

Construction of xenograft models of human endometrial cancer in NOD/SCID IL-2R gamma null mice

Principal Investigator

Project Period (FY)

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To investigate of anti-neoplastic effect of metformin in endometrial cancerPrincipal Investigator

Principal Investigator

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Research Institution

Study of PAX2 promoter methylation status in the carcinogenesis of estrogen dependent endometrial cancerPrincipal Investigator

Principal Investigator

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Research Institution

Basic and Clinical study on endocrine therapy of gynecologic diseases targeting aromatase

Principal Investigator

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Research Institution

子宮頸部癌における3p21.3領域のホモ欠失の検索Principal Investigator

Principal Investigator

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Research Institution

HPV陰性子宮頸部癌の発癌機構の解明Principal Investigator

Principal Investigator

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Research Institution

MOLECULAR MECHANISM INVOLVED IN ONCOGENESIS AND PROGRESSION OF OVARIAN CANCER

Principal Investigator

Project Period (FY)

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Research Institution

[Journal Article] Lymphadenectomy issues in endometrial cancer.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High prevalence of pulmonary embolism prior to cancer therapies in patients with ovarian and endometrial cancers detected by contrast‐enhanced CT using D‐dimer as an index2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Time-lapse monitoring of fertilized human oocytes focused on the incidence of 0PN embryos in conventional in vitro fertilization cycles. Kobayashi T, Ishikawa H, Ishii K, Sato A, Nakamura N, Saito Y, Hasegawa H, Fujita M, Mitsuhashi A, Shozu M.2021

Author(s)

Journal Title

Mitsuhashi Akira 三橋暁

MITSUHASHI Akira 三橋暁

三橋暁ミツハシアキラ

三橋曉ミツハシアキラ