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Mizutari Kunio  水足 邦雄

… Alternative Names

MIZUTARI Kunio  水足 邦雄

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Researcher Number 40338140
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0340-8293
Affiliation (Current) 2025: 東京女子医科大学, 医学部, 准教授
2025: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 耳鼻咽喉科, 講師
Affiliation (based on the past Project Information) *help 2022 – 2024: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 耳鼻咽喉科, 講師
2016 – 2021: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 耳鼻咽喉科科, 講師
2016: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 病院 耳鼻咽喉科科, 講師
2015 – 2016: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, 医師
2015: 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 講師 … More
2014 – 2015: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, その他
2014: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚・平衡覚研究部, 医師
2013: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚・平衡覚研究部, 研究員
2013: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚障害研究室, 研究員
2012: 独立行政法人国立病院機構(東京医療センター臨床研究センター), その他部局等, その他
2009: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚障害研究室, 研究員
2009: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 研究員
2008: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 聴覚障害研究室, 研究員
2007: 独立行政法人国立病院機構(東京医療センター臨床研究センター), 東京医療センター(臨床研究センター)・聴覚・平衡覚研究部, 研究員
2006: 独立行政法人国立病院機構(東京医療センター(臨床研究センター), 聴覚・平衡覚研究部, 研究員 Less
Review Section/Research Field
Principal Investigator
Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related
Except Principal Investigator
Basic Section 56050:Otorhinolaryngology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Otorhinolaryngology
Keywords
Principal Investigator
シナプス / 有毛細胞 / 3-nitropropionic acid / ミトコンドリア / 感音難聴 / 耳鳴 / 内耳 / 蝸牛内電位 / 難聴 / 大脳辺縁系 … More / 爆傷 / 扁桃体 / 聴覚障害 / 遺伝子治療 / ウイルスベクター / 細胞死 / 外有毛細胞 / 内有毛細胞 / エネルギー不全 / 内耳エネルギー不全 / 遅発性細胞脱落 / らせん神経節 / 再生 / 蝸牛外側壁 / 線維細胞 / 内耳障害 / 急性感音難聴 / 前庭有毛細胞 / 細胞移植 / 骨髄間葉系幹細胞 / 平衡障害 / 老人性難聴 … More
Except Principal Investigator
橋渡し研究 / 感音難聴 / 内耳 / ROCK阻害薬 / 聴覚医学 / 耳科学 / 内耳再生 / 霊長類研究 / 再生 / cochlear synaptopathy / hidden hearing loss / シナプス再生 / 爆傷 / 聴神経 / LISW / 有毛細胞 / シナプス / 霊長類モデル / 再生医療 / hiPS細胞 / EarFlow / 蝸牛シナプス障害 / 内視鏡下耳科手術 / ドラッグデリバリーシステム / 蝸牛シナプス / ヒューマノイドモデル / 多層臨床データオミクス / エイジング、アンチエイジング / 加齢性難聴 / 難聴 / IoTセンシング / 内耳性難聴 / バイオインフォマティクス / 聴覚障害 / iPS細胞創薬 / エクソソーム / 内耳有毛細胞保護薬剤 / 内耳障害 / シスプラチン難聴 / 器管培養コルチ器 / シスプラチン / 免疫染色 / confocal microscope / 器管培養 / コルチ器 / 衝撃波 / cochlear synaptopaty / 難聴医学 / 聴覚 / 神経 / 聴覚再生 / Hidden Hearing Loss / Cochlear Synaptopathy / 蝸牛 / 疾患特異的iPS / iPS創薬スクリーニング / トランスレーショナルリサーチ / 橋渡し研究加速 / マーモセット / iPS細胞スクリーニング / ヒトiPS細胞 / 薬剤スクリーニング / 創薬研究 / iPS細胞 Less
  • Research Projects

    (17 results)
  • Research Products

    (75 results)
  • Co-Researchers

    (36 People)
  •  難聴に随伴する聴覚認知異常の多階層的解析による新規治療法 の開発

    • Principal Investigator
      小野 宗範
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Kanazawa Medical University
  •  蝸牛シナプス障害をターゲットとした新規耳鳴治療の開発Principal Investigator

    • Principal Investigator
      水足 邦雄
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      National Defense Medical College
  •  多層臨床データの情報数理解析と幹細胞医学・発生工学の融合による加齢性難聴研究

    • Principal Investigator
      藤岡 正人
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kitasato University
  •  EarFlowを用いた蝸牛シナプス障害に対する新規治療の確立

    • Principal Investigator
      欠畑 誠治
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yamagata University
  •  感音難聴の新規病態に基づいた治療法の探索 -衝撃波による内耳障害モデルでの検討-

    • Principal Investigator
      小泉 優
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yamagata University
  •  耳鳴に対する分子遺伝学的解析を基盤とした新規薬物治療の開発Principal Investigator

    • Principal Investigator
      水足 邦雄
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      National Defense Medical College
  •  シスプラチン難聴予防薬剤の臨床応用に向けた内耳障害予防と抗腫瘍効果の比較検討

    • Principal Investigator
      荒井 康裕
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Yokohama City University
  •  Integrated understanding of inner ear disorders and next-generation drug discovery by combination of IoT sensing and iPSC-based medicine

    • Principal Investigator
      Fujioka Masato
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Kitasato University
  •  Establishment of new regenerative therapy for cochlear synaptopathy

    • Principal Investigator
      Kakehata Seiji
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Yamagata University
  •  Development of new treatments for tinnitus and analysis of its effects on the limbic systemPrincipal Investigator

    • Principal Investigator
      Mizutari Kunio
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      National Defense Medical College
  •  Development of novel therapeutics for the cochlear hearing impairments by using hiPSCs and common marmoset models

    • Principal Investigator
      FUJIOKA Masato
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Keio University
  •  Pre-clinical proof of concept trials for auditory hair cell regeneration by using hiPSC technology and marmoset model

    • Principal Investigator
      Fujioka Masato
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Keio University
  •  Mechanisms of delayed degeneration of hair cells and spiral ganglion cellPrincipal Investigator

    • Principal Investigator
      Mizutari Kunio
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      National Defense Medical College
      独立行政法人国立病院機構(東京医療センター臨床研究センター)
  •  Drug screening and development using hES/iPSC-derived otic progenitor

    • Principal Investigator
      Ogawa Kaoru
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Keio University
  •  Mechanism of cochlear lateral wall fibrocytes regenerationPrincipal Investigator

    • Principal Investigator
      MIZUTARI Kunio
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      独立行政法人国立病院機構(東京医療センター臨床研究センター)
  •  Mesenchymal stem cell transplantation for the vestibular organ of acute inner ear energy failurPrincipal Investigator

    • Principal Investigator
      MIZUTARI Kunio
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      独立行政法人国立病院機構(東京医療センター臨床研究センター)
  •  加齢性内耳障害モデルラットの作成、病態および予防法の研究Principal Investigator

    • Principal Investigator
      水足 邦雄
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      独立行政法人国立病院機構(東京医療センター臨床研究センター)

All 2024 2023 2022 2021 2020 2019 2018 2016 2015 2014 2013 2012 2010 2009 2008 Other

All Journal Article Presentation Book

  • [Book] 「12. 中等度難聴児にふさわしい補聴器」小児の中等度難聴ハンドブック(編集:加我君孝、内山勉、新正由紀子)2009

    • Author(s)
      水足邦雄
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-20791238
  • [Book] 「12.中等度難聴児にふさわしい補聴器」小児の中等度難聴ハンドブック2009

    • Author(s)
      水足邦雄(共同執筆)
    • Total Pages
      7
    • Publisher
      金原出版
    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Research Application of Laser-induced Shock Wave for Studying Blast-induced Cochlear Injury2024

    • Author(s)
      Kurioka Takaomi、Mizutari Kunio、Niwa Katsuki、Kimura Eiko、Kawauchi Satoko、Kobayashi Yasushi、Sato Shunichi
    • Journal Title

      Journal of Visualized Experiments

      Volume: - Issue: 205

    • DOI

      10.3791/66396

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K15901, KAKENHI-PROJECT-21K09573
  • [Journal Article] Blast-Induced Central Auditory Neurodegeneration Affects Tinnitus Development Regardless of Peripheral Cochlear Damage2024

    • Author(s)
      Kurioka Takaomi、Mizutari Kunio、Satoh Yasushi、Kobayashi Yasushi、Shiotani Akihiro
    • Journal Title

      Journal of Neurotrauma

      Volume: 41 Issue: 3-4 Pages: 499-513

    • DOI

      10.1089/neu.2023.0259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23K15901, KAKENHI-PROJECT-21K09573
  • [Journal Article] Effects of Unilateral Vagotomy on LPS-Induced Aspiration Pneumonia in Mice2023

    • Author(s)
      Tatsushima Daisuke、Kurioka Takaomi、Mizutari Kunio、Suzuki Jun、Ikeda Ryoukichi、Hisaoka Takuma、Koshiba Yasutoshi、Takahashi Hiyori、Hashimoto Hikaru、Katori Yukio、Shiotani Akihiro
    • Journal Title

      Dysphagia

      Volume: - Issue: 5 Pages: 1353-1362

    • DOI

      10.1007/s00455-023-10564-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K18263, KAKENHI-PROJECT-23K15901, KAKENHI-PROJECT-21K09573, KAKENHI-PROJECT-22K09697
  • [Journal Article] A New Animal Model for Hearing Loss and Tinnitus Utilized by Laser Technology2023

    • Author(s)
      Mizutari Kunio
    • Journal Title

      The Journal of Japan Society for Laser Surgery and Medicine

      Volume: 43 Issue: 4 Pages: 231-236

    • DOI

      10.2530/jslsm.jslsm-43_0016

    • ISSN
      0288-6200, 1881-1639
    • Year and Date
      2023-01-15
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-21K09573
  • [Journal Article] Correlation of Blast-Induced Tympanic Membrane Perforation with Peripheral Cochlear Synaptopathy2022

    • Author(s)
      Kurioka Takaomi、Mizutari Kunio、Satoh Yasushi、Shiotani Akihiro
    • Journal Title

      Journal of Neurotrauma

      Volume: 39 Issue: 13-14 Pages: 999-1009

    • DOI

      10.1089/neu.2021.0487

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09573, KAKENHI-PROJECT-20K18263
  • [Journal Article] Factors affecting the incidence of chorda tympani nerve transection in middle ear surgery2022

    • Author(s)
      Takihata Saki、Kurioka Takaomi、Mizutari Kunio、Shiotani Akihiro
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 7 Issue: 6 Pages: 2088-2094

    • DOI

      10.1002/lio2.976

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09573, KAKENHI-PROJECT-20K18263
  • [Journal Article] Patency of Anterior Epitympanic Space and Surgical Outcomes After Endoscopic Ear Surgery for the Attic Cholesteatoma.2021

    • Author(s)
      Mizutari, K., Takihata, S., Kimura, E., Inuzuka, E. & Shiotani, A.
    • Journal Title

      Otol Neurotol

      Volume: 42 Issue: 2 Pages: 266-273

    • DOI

      10.1097/mao.0000000000002872

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K09573
  • [Journal Article] Y-27632, a ROCK inhibitor, improved laser-induced shock wave (LISW)-induced cochlear synaptopathy in mice.2021

    • Author(s)
      Koizumi, Y., Mizutari, K., Kawauchi, S., Sato, S., Shiotani, A. & Kakehata
    • Journal Title

      Mol Brain

      Volume: 14 Issue: 1 Pages: 105-105

    • DOI

      10.1186/s13041-021-00819-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09335, KAKENHI-PROJECT-20H03833, KAKENHI-PROJECT-21K09555, KAKENHI-PROJECT-21K09573, KAKENHI-PROJECT-20KK0204
  • [Journal Article] Tinnitus rat model generated by laser-induced shock wave; a platform for analyzing the central nervous system after tinnitus generation.2021

    • Author(s)
      Niwa K, Mizutari K, Matsui T, Kawauchi S, Sato S, Shiotani A, Kobayashi Y.
    • Journal Title

      Auris Nasus Larynx

      Volume: 48 Issue: 1 Pages: 82-89

    • DOI

      10.1016/j.anl.2020.07.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Journal Article] Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss2021

    • Author(s)
      Kimura, E., Mizutari, K., Kurioka, T., Kawauchi, S., Satoh, Y., Sato, S. & Shiotani, A.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 14704-14704

    • DOI

      10.1038/s41598-021-94080-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09335, KAKENHI-PROJECT-21K09573, KAKENHI-PROJECT-20K18263
  • [Journal Article] Regenerative Effect of a ROCK Inhibitor, Y-27632, on Excitotoxic Trauma in an Organotypic Culture of the Cochlea2020

    • Author(s)
      Koizumi Y, Ito T, Mizutari K, Kakehata S.
    • Journal Title

      Front. Cell. Neurosci.

      Volume: 14 Pages: 572434-572434

    • DOI

      10.3389/fncel.2020.572434

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09335, KAKENHI-PROJECT-20KK0204, KAKENHI-PROJECT-17K19713, KAKENHI-PROJECT-17K16887, KAKENHI-PROJECT-20H03833
  • [Journal Article] The influence of a noisy environment on hearing impairment and tinnitus: The hearing outcomes of 50-year-old male Japan ground self-defense force personnel.2020

    • Author(s)
      Takihata S, Mizutari K, Morita I, Matsuo H, Nakayama A, Shimizu S, Ueno M, Ito T, Shinomiya N, Shiotani A.
    • Journal Title

      Auris Nasus Larynx

      Volume: 47 Issue: 6 Pages: 931-937

    • DOI

      10.1016/j.anl.2020.05.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09335, KAKENHI-PROJECT-18H02685
  • [Journal Article] Update on treatment options for blast-induced hearing loss.2019

    • Author(s)
      Mizutari K
    • Journal Title

      Curr Opin Otolaryngol Head Neck Surg.

      Volume: 27(5) Issue: 5 Pages: 376-380

    • DOI

      10.1097/moo.0000000000000563

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Journal Article] A Case of Gastric Meningeal Carcinomatosis Involving Bilateral Hearing Loss: The Difference between Clinical Images and Autopsy Findings.2019

    • Author(s)
      Kimura A, Takahashi Y, Mizutari K, Tsujimoto H, Nakanishi K, Shiotani A.
    • Journal Title

      J Int Adv Otol.

      Volume: 15(2) Issue: 2 Pages: 333-336

    • DOI

      10.5152/iao.2019.6080

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Journal Article] Blast-induced hearing loss.2019

    • Author(s)
      Mizutari K.
    • Journal Title

      J Zhejiang Univ Sci B.

      Volume: 20(2) Issue: 2 Pages: 111-115

    • DOI

      10.1631/jzus.b1700051

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Journal Article] NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea2016

    • Author(s)
      Honkura, Y. Matsuo, H. Murakami, S. Sakiyama, M. Mizutari, K. Shiotani, A. Yamamoto, M. Morita, I. Shinomiya, N. Kawase, T. Katori, Y. Motohashi, H.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 19329-19329

    • DOI

      10.1038/srep19329

    • NAID

      130005260938

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462572, KAKENHI-PROJECT-15K15227, KAKENHI-PROJECT-15K18999, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-25293145, KAKENHI-WRAPUP-16H01688, KAKENHI-PROJECT-15H04315
  • [Journal Article] Recovery of endocochlear potential after severe damage to lateral wall fibrocytes following acute cochlear energy failure2016

    • Author(s)
      Kitao, K. Mizutari, K. Nakagawa, S. Matsunaga, T. Fukuda, S. Fujii, M.
    • Journal Title

      Neuroreport

      Volume: 27 Issue: 15 Pages: 1159-66

    • DOI

      10.1097/wnr.0000000000000673

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26462572
  • [Journal Article] Hyaluronic acid pretreatment for Sendai virus-mediated cochlear gene transfer.2016

    • Author(s)
      Kurioka T, Mizutari K, Niwa K, Fukumori T, Inoue M, Hasegawa M, Shiotani A.
    • Journal Title

      Gene Ther

      Volume: 23 Issue: 2 Pages: 187-95

    • DOI

      10.1038/gt.2015.94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462572
  • [Journal Article] High prevalence of CDH23 mutation in patients with congenital high-frequency recessive or sporadic hereditary hearing loss2015

    • Author(s)
      Mizutari K, Mutai H., Namba K., Miyanaga Y., Nakano A., Arimoto Y., Masuda S., Morimoto N., Sakamoto H., Kaga K., Matsunaga T.
    • Journal Title

      Orphanet Journal of Rare Diseases

      Volume: 10 Issue: 1 Pages: 60-60

    • DOI

      10.1186/s13023-015-0276-z

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24592573, KAKENHI-PROJECT-15K10773, KAKENHI-PROJECT-26462572
  • [Journal Article] Spontaneous recovery of cochlear fibrocytes after severe degeneration caused by acute energy failure.2014

    • Author(s)
      Mizutari K
    • Journal Title

      Front Pharmacol.

      Volume: 5 Pages: 198-198

    • DOI

      10.3389/fphar.2014.00198

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462572
  • [Journal Article] Tinnitus preceded depressive symptoms in community-dwelling older Japanese: a prospective cohort study.2013

    • Author(s)
      Michikawa T, Nishiwaki Y, Saito H, Mizutari K, Takebayashi T.
    • Journal Title

      Prev Med

      Volume: 56(5) Issue: 5 Pages: 333-336

    • DOI

      10.1016/j.ypmed.2013.01.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390156, KAKENHI-PROJECT-24791818
  • [Journal Article] Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma2013

    • Author(s)
      Mizutari K, Fujioka M, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS
    • Journal Title

      Neuron

      Volume: 77(1) Pages: 58-69

    • NAID

      130005165986

    • Data Source
      KAKENHI-PROJECT-24791818
  • [Journal Article] Tinnitus preceded depressive symptoms in community-dwelling older Japanese : A prospective cohort study2013

    • Author(s)
      Michikawa T, Nishiwaki Y, Saito H, Mizutari K, Takebayashi T
    • Journal Title

      Prev Med

      Volume: 56(5) Pages: 333-6

    • Data Source
      KAKENHI-PROJECT-24791818
  • [Journal Article] Age-Related Hearing Loss and the Factors Determining Continued Usage of Hearing Aids among Elderly Community-Dwelling Residents2013

    • Author(s)
      Mizutari K, Michikawa T, Saito H, Okamoto Y, Enomoto C, Takebayashi T, Ogawa K, Nishiwaki Y
    • Journal Title

      PLoS One

      Volume: 8(9)

    • Data Source
      KAKENHI-PROJECT-24791818
  • [Journal Article] Age-related hearing loss and the factors determining continued usage of hearing aids among elderly community-dwelling residents.2013

    • Author(s)
      Mizutari K, Michikawa T, Saito H, Okamoto Y, Enomoto C, Takebayashi T, Ogawa K, Nishiwaki Y.
    • Journal Title

      PLoS One

      Volume: 8(9) Issue: 9 Pages: e73622-e73622

    • DOI

      10.1371/journal.pone.0073622

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390156, KAKENHI-PROJECT-24791818
  • [Journal Article] Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma2013

    • Author(s)
      Fujioka M, Mizutari K, Hosoya M, Bramhall N, Okano HJ, Okano H, Edge AS
    • Journal Title

      Neuron

      Volume: 77(1) Issue: 1 Pages: 58-69

    • DOI

      10.1016/j.neuron.2012.10.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592560, KAKENHI-PROJECT-24791818
  • [Journal Article] A novel animal model of hearing loss caused by acute endoplasmic reticulum stress in the cochlea2012

    • Author(s)
      Fujinami Y, Mutai H, Mizutari K, Nakagawa S, Matsunaga T
    • Journal Title

      J Pharmacol Sci

      Volume: 118(3) Pages: 363-363

    • NAID

      10030455675

    • Data Source
      KAKENHI-PROJECT-24791818
  • [Journal Article] A novel animal model of hearing loss caused by acute endoplasmic reticulum stress in the cochlea.2012

    • Author(s)
      Fujinami Y, Mutai H, Mizutari K, Nakagawa S, Matsunaga T.
    • Journal Title

      J Pharmacol Sci.

      Volume: 118 Pages: 363-72

    • NAID

      10030455675

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Journal Article] Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid.2010

    • Author(s)
      Fujinami Y, Mutai H, Kamiya K, Mizutari K, Fujii M, Matsunaga T
    • Journal Title

      Neurochem Int. 56(3)

      Pages: 487-494

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Hearing handicap predicts the development of depressive symptoms after 3 years in older community-dwelling Japanese.2010

    • Author(s)
      Saito H, Nishiwaki Y, Michikawa T, Kikuchi Y, Mizutari K, Takebayashi T, Ogawa K
    • Journal Title

      J Am Geriatr Soc. 58(1)

      Pages: 93-97

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid.2010

    • Author(s)
      Fujinami Y, Mutai H, Kamiya K, Mizutari K, Fujii M, Matsunaga T.
    • Journal Title

      Neurochem Int. 56

      Pages: 487-494

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Hearing handicap predicts the development of depressive symptoms after 3 years in older community-dwelling Japanese.2010

    • Author(s)
      Saito H, Nishiwaki Y, Michikawa T, Mizutari K, Takebayashi T, Ogawa K.
    • Journal Title

      J Am Geriatr Soc. 58

      Pages: 93-97

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese: a population-based cohort study.2009

    • Author(s)
      Michikawa T, Nishiwaki Y, Kikuchi Y, Nakano M, Iwasawa S, Asakura K, Milojevic A, Mizutari K, Saito H, Ishida S, Okamura T, Takebayashi T
    • Journal Title

      BMC Geriatr. 22

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Serum Levels of Retinol and Other Antioxidants for Hearing Impairment Among Japanese Older Adults.2009

    • Author(s)
      Michikawa T, Nishiwaki Y, Kikuchi Y, Hosoda K, Mizutari K, Saito H, Asakura K, Milojevic A, Iwasawa S, Nakano M, Takebayashi T
    • Journal Title

      J Gerontol A Biol Sci Med Sci. 64(8)

      Pages: 910-915

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese : a population-based cohort study.2009

    • Author(s)
      Michikawa T, Nishiwaki Y, Kikuchi Y., Mizutari K, Saito H, Takebayashi T.
    • Journal Title

      BMC Geriatr. 22

      Pages: 50-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Caspase Inhibitor Facilitates Recovery of Hearing by Protecting the Cochlear Lateral Wall from Acute Cochlear Mitochondrial Dysfunction2008

    • Author(s)
      Mizutari K
    • Journal Title

      Journal of Neuroscience Research 86

      Pages: 215-222

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18791251
  • [Journal Article] Oropharyngeal tuberculosis2008

    • Author(s)
      Mizutari K, Tsunoda K, Matsunaga T, Masuda K, Fujii R, Fujii M
    • Journal Title

      Internal Medicine Journal 38(6)

      Pages: 449-450

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] 耳科手術における周術期レボフロキサシン経口投与の有用性と適応の検討2008

    • Author(s)
      水足邦雄、斉藤秀行、神崎晶、鈴木隆史、大石直樹、岡本康秀、栗田昭宏、井上泰宏、小川郁
    • Journal Title

      Otology Japan 2008 18(2)

      Pages: 120-125

    • NAID

      10025821422

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] 補聴器-補聴器の最近の進歩-図説感 覚器疾患シリーズ2008

    • Author(s)
      水足邦雄
    • Journal Title

      医療 62(5)

      Pages: 302-305

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] Oropharyngeal tuberculosis2008

    • Author(s)
      Mizutari K
    • Journal Title

      Intern Med J 38

      Pages: 449-450

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20791238
  • [Journal Article] 補聴器の最新知見「インテリジェンス補聴器」特集2008

    • Author(s)
      水足邦雄
    • Journal Title

      補聴器と人工内耳-最近の進歩と将来展望- JOHNS 2008 24(9)

      Pages: 1307-1311

    • Data Source
      KAKENHI-PROJECT-20791238
  • [Presentation] Evaluation of the Effects of Rock Inhibitors on Auditory Damage Model Caused by Blast Exposure in CBA/J.2024

    • Author(s)
      Yutaka Koizumi, Aaron Remenschneider, Jeffrey Cheng, Christopher J. Smal, Kunio Mizutari, Seiji Kakehata
    • Organizer
      Association for Research in Otolaryngology 47th Annual MidWinter Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09555
  • [Presentation] Evaluation of the Effects of ROCK Inhibitors on Auditory Damage Model Caused by Blast Exposure in CBA/J.2024

    • Author(s)
      Yutaka Koizumi, Aaron K Remenschneider, Jeffrey Tao Cheng, Christopher J Smalt, Kunio Mizutari, Seiji Kakehata
    • Organizer
      Association for Research in Otolaryngology 47th Annual MidWinter Meeting
    • Data Source
      KAKENHI-PROJECT-20KK0204
  • [Presentation] Evaluation of auditory damage after blast exposure in mice.2023

    • Author(s)
      Yutaka Koizumi, Aaron K Remenschneider, Jeffrey Tao Cheng, Christopher J Smalt, Kunio Mizutari, Seiji Kakehata
    • Organizer
      Association for Research in Otolaryngology 46th Annual MidWinter Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09555
  • [Presentation] 他覚的聴覚検査の基本と臨床2023

    • Author(s)
      水足邦雄
    • Organizer
      第68回日本聴覚医学会総会・学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K09573
  • [Presentation] Gap detection ability declines in an early stages of age-related hearing impairment2023

    • Author(s)
      Takaomi Kurioka, Kunio Mizutari
    • Organizer
      The 47th annual midwinter meeting of Association for Research in Otolaryngology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09573
  • [Presentation] Pathophysiological assessment of blast-induced perilymphatic fistula2023

    • Author(s)
      Yoshiaki Inuzuka, Kunio Mizutari, Takaomi Kurioka, Tomohiro Matsumura, Han Matsuda, Tetsuo Ikezono, Akihiro Shiotani
    • Organizer
      The 47th annual midwinter meeting of Association for Research in Otolaryngology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K09573
  • [Presentation] Evaluation of auditory damage after blast exposure in mice.2023

    • Author(s)
      Yutaka Koizumi, Aaron K Remenschneider, Jeffrey Tao Cheng, Christopher J Smalt, Kunio Mizutari, Seiji Kakehata
    • Organizer
      Association for Research in Otolaryngology 46th Annual MidWinter Meeting
    • Data Source
      KAKENHI-PROJECT-20KK0204
  • [Presentation] Laser-induced shock waveによるcochlear synaptopathyモデルに対するROCK阻害薬の効果の検討2021

    • Author(s)
      小泉 優, 水足 邦雄, 伊藤 吏, 塩谷 彰浩, 欠畑 誠治
    • Organizer
      第31回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-20KK0204
  • [Presentation] Laser-induced shock waveによるcochlear synaptopathyモデルに対するROCK阻害薬の効果の検討2021

    • Author(s)
      小泉 優, 水足 邦雄, 伊藤 吏, 塩谷 彰浩, 欠畑 誠治
    • Organizer
      第31回日本耳科学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-21K09555
  • [Presentation] 補聴器適合に役立つ検査 実耳測定とワイドバンドティンパノメトリ-2019

    • Author(s)
      水足邦雄
    • Organizer
      第64回日本聴覚医学会総会・学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Presentation] Pathophysiological differences of hearing impairment between two types of blast induced hearing loss2019

    • Author(s)
      Kunio Mizutari, Eiko Kimura, Katsuki Niwa, Yasushi Satoh, Shun-ichi Sato, and Akihiro Shiotani
    • Organizer
      15th Meeting of the International Otopathology Society
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Presentation] Cochlear histopathology after shock wave exposure.2019

    • Author(s)
      Eiko Harada, Kunio Mizutari
    • Organizer
      42th ARO Midwinter Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Presentation] 爆傷による中耳・内耳障害の実態 臨床と基礎研究の最前線2019

    • Author(s)
      水足邦雄
    • Organizer
      第67回聴覚生理研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Presentation] The technique of opening anterior ventilation route under ossicular chain preservation2019

    • Author(s)
      Kunio Mizutari, Eiko Kimura, Saki Takihata, and Akihiro Shiotani
    • Organizer
      3rd World Congress on Endoscopic Ear Surgery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K09335
  • [Presentation] Topical administration of a gamma-secretase inhibitor LY411575 into the round window niche ameliorates permanent threshold shift in a noise-induced hearing loss model of a non-human primate, the common marmoset2018

    • Author(s)
      Masato Fujioka,Tamohiko Yashida ,ShoKurihara, Makoto Koizumi, Makoto Hosaya, Hirotaka James Okano, Hiromi Kojima, Kunio Mizutari, Kaoru Ogawa, Albert Edge
    • Organizer
      55th Inner Ear Biology Workshop
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H04065
  • [Presentation] Recovery of endocochlear potential after severe damage to lateral wall fibrocytes following acute cochlear energy failure2016

    • Author(s)
      Kunio Mizutari, Kyoko Kitao, Susumu Nakagawa, Tatsuo Matsunaga, Satoshi Fukuda, Masato Fujii
    • Organizer
      53rd Inner Ear Biology Workshop
    • Place of Presentation
      Montpellier, France
    • Year and Date
      2016-09-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462572
  • [Presentation] Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma2013

    • Author(s)
      Mizutari K, Fujioka M, Hosoya M, , Okano HJ, Okano H, Edge AS
    • Organizer
      The 29th Politzer Society Meeting
    • Place of Presentation
      Antalya, Turkey
    • Year and Date
      2013-11-14
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] HbA1c と加齢性難聴の関連に関する横断・縦断的検討 : 倉渕高齢者コーホート2013

    • Author(s)
      水足邦雄, 西脇祐司, 斉藤秀行, 小川郁
    • Organizer
      第58回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      松本
    • Year and Date
      2013-10-24
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] CDH23遺伝子変異による遺伝西南緒の臨床像2013

    • Author(s)
      水足邦雄, 仲野敦子, 有本友季子, 増田佐和子, 阪本浩一, 守本倫子, 瀧口哲也, 小河原昇, 加我君孝, 松永達雄
    • Organizer
      日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌
    • Year and Date
      2013-05-18
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] Notch 情報伝達系阻害による蝸牛有毛細胞の機能的再生2013

    • Author(s)
      水足邦雄, 藤岡正人, 細谷誠, 小川郁
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      インストラクションコース3, 宮崎
    • Year and Date
      2013-11-24
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] Intracochlear Tamoxifen Distribution Visualized by a Cre-Lox System2013

    • Author(s)
      KunioMizutari, Sewell WF, Edge AS
    • Organizer
      36st ARO Midwinter Meeting
    • Place of Presentation
      Baltimore, MD, USA
    • Year and Date
      2013-02-18
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] 内耳の発生・再生に関する最新知見レポーターマウスを用いた内耳ドラッグデリバリーの新規研究法2012

    • Author(s)
      水足邦雄
    • Organizer
      日本耳科学会学術講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-05
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] 地域在住高齢者における耳鳴と抑うつ傾向との関連 倉渕高齢者コーホート2012

    • Author(s)
      水足邦雄, 西脇祐司, 齊藤秀行, 小川郁
    • Organizer
      日本聴覚医学会学術講演会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-11
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] 蝸牛らせん靱帯の継続的修復と聴覚改善2008

    • Author(s)
      水足邦雄
    • Organizer
      第18回日本耳科学会総会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-16
    • Data Source
      KAKENHI-PROJECT-20791238
  • [Presentation] Regeneration of the Cochlear Fibrocytes Leads to Partial Hearing Recovery in a Model of Persistent Hearing Loss Due to Acute Cochlear Energy Failure

    • Author(s)
      Mizutari K
    • Organizer
      31st ARO Midwinter Meeting
    • Place of Presentation
      Phoenix,AZ,USA
    • Data Source
      KAKENHI-PROJECT-18791251
  • [Presentation] 地域在住高齢者における耳鳴と抑うつ傾向との関連―倉渕高齢者コーホートー

    • Author(s)
      水足邦雄 道川武紘 西脇祐司 齊藤秀行 武林亨 小川郁
    • Organizer
      第57回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] Intracochlear Tamoxifen Distribution Visualized by a Cre-Lox System

    • Author(s)
      Mizutari K, Sewell WF, and Edge AS
    • Organizer
      36st ARO Midwinter Meeting
    • Place of Presentation
      Baltimore, MD, USA
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] レポーターマウスを用いた内耳ドラッグデリバリーの新規研究法

    • Author(s)
      水足邦雄
    • Organizer
      第22回日本耳科学会総会・学術講演会
    • Place of Presentation
      名古屋市
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] CDH23遺伝子変異による遺伝性難聴の臨床像

    • Author(s)
      水足 邦雄, 仲野 敦子, 有本 友季子, 増田 佐和子, 阪本 浩一, 守本 倫子, 瀧口 哲也, 小河原 昇, 加我 君孝, 松永 達雄
    • Organizer
      第114回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] Notch情報伝達系阻害による蝸牛有毛細胞の機能的再生

    • Author(s)
      水足邦雄、藤岡正人、細谷誠、小川郁
    • Organizer
      第23回日本耳科学会総会・学術講演会
    • Place of Presentation
      宮崎
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] HbA1cと加齢性難聴の関連に関する横断・縦断的検討:倉渕高齢者コーホート

    • Author(s)
      水足邦雄、西脇祐司、斉藤秀行、小川郁
    • Organizer
      第58回日本聴覚医学会総会・学術講演会
    • Place of Presentation
      松本
    • Data Source
      KAKENHI-PROJECT-24791818
  • [Presentation] Notch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.

    • Author(s)
      Mizutari K, Fujioka M, Hosoya M, , Okano HJ, Okano H, Edge AS.
    • Organizer
      The 29th Politzer Society Meeting
    • Place of Presentation
      Antalya, Turkey
    • Data Source
      KAKENHI-PROJECT-24791818
  • 1.  Fujioka Masato (70398626)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 2.  Ogawa Kaoru (00169179)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 3.  Kakehata Seiji (90261619)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 4.  岡野 ジェイムス洋尚 (90338020)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  細谷 誠 (30645445)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  小泉 優 (80723585)
    # of Collaborated Projects: 3 results
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  • 27.  務台 英樹 (60415891)
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  • 28.  吉川 欣亮 (20280787)
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  • 32.  MICHIKAWA Takehiro
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  • 33.  武林 亨
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  • 34.  西脇 祐司
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  • 35.  栗岡 隆臣
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  • 36.  宮 冬樹
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