Shiohama Aiko 塩濱愛子

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SHIOHAMA Aiko 塩濱愛子

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Researcher Number	40383731
Other IDs	https://orcid.org/0000-0003-4008-108X
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 特任助教
Affiliation (based on the past Project Information) *help	2018 – 2019: 慶應義塾大学, 医学部(信濃町), 特任助教 2017: 慶應義塾大学, 医学部, 助教 2017: 慶應義塾大学, 医学部, 特任助教 2016: 慶應義塾大学, 医学部(信濃町), 特任助教 2014 – 2015: 慶應義塾大学, 医学部, 助教 … More 2014: 慶應義塾大学, 医学部, 特任助教 2011 – 2012: 慶應義塾大学, 医学部, 特任助教 2010: Keio University, 医学部, 助教 2007 – 2008: Keio University, 医学部, 助教 2005 – 2006: 慶應義塾大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Embryonic/Neonatal medicine Except Principal Investigator Dermatology / Biological Sciences / 基礎ゲノム科学
Keywords	Principal Investigator ゲノムシーケンシング / ゲノム解析 / 遺伝性角化症 / 皮膚遺伝学 / フィラグリン / モデルマウス / アトピー性皮膚炎 / 菌叢解析 / 表皮 / SG1 … More / 遺伝子多型 / DiGeore症候群 / モデル生物 / DiGeorge症候群 / miRNA / 発生 / 先天性疾患 / 遺伝子診断 / 染色体異常 … More Except Principal Investigator アトピー性皮膚炎 / 比較ゲノム解析 / 細菌叢 / Tmem79 / フィラグリン / 皮膚バリア / ノックダウン解析 / モルフォリノアンチセンス / モチーフ / ドメイン / カオナシ / モルフォリノ / ノックダウン / メダカ / 家族性てんかん / 多発性嚢胞腎 / コーエン症侯群 / ディジョージ症候群 / 遺伝子疾患 / ヒトゲノム / 医療 / 発生・分化 / タンパク質 / 遺伝子 / ゲノム / 新規遺伝子 / 疾患 / ゲノム解析 Less

To Establish a treatment method for the Nagashima-type palmoplantar keratosis based on the fine analysis of genome variation and skin microbiotaPrincipal Investigator
- Principal Investigator
  
  SHIOHAMA Aiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Elucidation for mechanism of dermatitis with model mice which develop dermatitis spontaneously with S.aureus proliferation.
- Principal Investigator
  
  SASAKI TAKASHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
The elucidation of the Nagashima-type palmoplantar keratosis caused by SERPINB7 protease inhibitor deficiencyPrincipal Investigator
- Principal Investigator
  
  SHIOHAMA Aiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Clarification of the pathogenesis of atopic disease by using filaggrin deficient mice in dry environment
- Principal Investigator
  
  Kawasaki Hiroshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Analysis of ma1,candidate responsible gene for atopic dermatitis, andelucidation of molecular mechanism for the dermatitis caused by ma1 deficiencyPrincipal Investigator
- Principal Investigator
  
  SHIOHAMA Aiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Identification of responsible gene for atopic dermatitis in mice modelPrincipal Investigator
- Principal Investigator
  
  SHIOHAMA Aiko
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dermatology
- Research Institution
  Keio University
An Integrated Strategy for Unveiling the Function of KAONASHI Unknown (Functional) Genes
- Principal Investigator
  
  SHIMIZU Nobuyoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  基礎ゲノム科学
- Research Institution
  Keio University
Analysis of the developmental process under miRNA and pathogenesis of DiGeorge syndromePrincipal Investigator
- Principal Investigator
  
  SHIOHAMA Aiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Keio University
ヒトゲノム解析から発見した注目すべき8個の新規遺伝子の機能解析と医療への応用
- Principal Investigator
  
  清水信義
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
ヒトゲノム解読から発見した注目すべき8個の新規遺伝子の機能解析と医療への応用
- Principal Investigator
  
  SHIMIZU Nobuyoshi
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
マイクロサテライト配列を利用した微小欠失領域の迅速同定法の確立Principal Investigator
- Principal Investigator
  
  塩濱愛子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Keio University

All 2019 2018 2017 2016 2011 2007

All Journal Article Presentation

[Journal Article] A nonepidermolytic keratinocytic epidermal naevus associated with a postzygotic mutation in the gene encoding epidermal growth factor receptor2019
- Author(s)
  Umegaki‐Arao N.、Ono N.、Tanaka R.、Sasaki T.、Fujita H.、Shiohama A.、Aoki S.、Amagai M.、Kubo A.
- Journal Title
  
  British Journal of Dermatology
  
  Volume: - Issue: 5 Pages: 1303-1305
- DOI
  10.1111/bjd.18729
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10252, KAKENHI-PROJECT-18K08310
[Journal Article] Clonal Expansion of Second-Hit Cells with Somatic Recombinations or C>T Transitions Form Porokeratosis in MVD or MVK Mutant Heterozygotes2019
- Author(s)
  Kubo Akiharu、Sasaki Takashi、Suzuki Hisato、Shiohama Aiko、Aoki Satomi、Sato Showbu、Fujita Harumi、Ono Noriko、Umegaki-Arao Noriko、Kawai Tomoko、Nakabayashi Kazuhiko、Hata Kenichiro、Yamada Daisuke、Matsubara Yoichi、Kosaki Kenjiro、Amagai Masayuki
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 139 Issue: 12 Pages: 2458-2466.e9
- DOI
  10.1016/j.jid.2019.05.020
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08310, KAKENHI-PROJECT-17K10252
[Journal Article] Three cases of Nagashima-type palmoplantar keratosis associated with atopic dermatitis: A diagnostic pitfall2017
- Author(s)
  Yamauchi Aiko、Kubo Akiharu、Ono Noriko、Shiohama Aiko、Tsuruta Daisuke、Fukai Kazuyoshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 45 Issue: 5
- DOI
  10.1111/1346-8138.14152
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10252
[Journal Article] Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma.2017
- Author(s)
  Adachi A, Komine M, Maekawa T, Murata S, Shiohama A, Kubo A, Ohtsuki M.
- Journal Title
  
  Acta Derm Venereol.
  
  Volume: - Issue: 6 Pages: 756-758
- DOI
  10.2340/00015555-2640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461701
[Journal Article] Novel nonsense mutation in SERPINB7 and the treatment of foot odor in a patient with Nagashima-type palmoplantar keratosis.2017
- Author(s)
  Katsuno M, Shiohama A, Aoki S, Kitamura H, Sasaki T, Amagai M, Kubo A.
- Journal Title
  
  J Dermatol.
  
  Volume: - Issue: 7
- DOI
  10.1111/1346-8138.13880
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461701
[Journal Article] Novel frame-shift mutation in SERPINB7 in a Japanese patient with Nagashima-type palmoplantar keratosis.2016
- Author(s)
  Nakajima K, Ishiguro M, Shiohama A, Kubo A, Sano S.
- Journal Title
  
  J Dermatol.
  
  Volume: - Issue: 7 Pages: 841-843
- DOI
  10.1111/1346-8138.13556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461701, KAKENHI-PROJECT-15K09769
[Journal Article] Identification and Characterization of a Recessive Missense Mutation p.P277L in SERPINB7 in Nagashima-Type Palmoplantar Keratosis2016
- Author(s)
  A.Shiohama, T.Sasaki, S.Sato, J.Sakabe, T.Ito, H.Isoda, Y.Zenke, T.Nakano, T.Maeda, A.Ishiko, K.Kabashima, Y.Tokura, Y.Mitsuhashi, M.Amagai, A.Kubo
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 136 Issue: 1 Pages: 325-328
- DOI
  10.1038/jid.2015.347
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461701
[Journal Article] Radiation hybrid maps of Medaka chromosomes LG 12, 17, and 222007
- Author(s)
  Su, F., Osada, Y., Ekker, M., Chevrette, M., Shimizu, A., Asakawa, S., Shiohama, A., Sasaki, T., Shimizu. N., Yamanaka, T., Sasado, T., Mitani, H., Geisler, R., Kondoh, H., Furutani-Seiki, M.
- Journal Title
  
  DNA Res 14(3)
  
  Pages: 135-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201038
[Journal Article] Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins.2007
- Author(s)
  Shiohama A.
- Journal Title
  
  Exp. Cell Res. 313
  
  Pages: 4196-4207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18018037
[Presentation] Postnatal somatic recombinations and C>T transition mutations are two major triggers of disseminated superficial actinic porokeratosis in MVD or MVK mutant heterozygotes.2019
- Author(s)
  Kubo A, Sasaki T, Suzuki H, Shiohama A, Aoki S, Kawai T, Nakabayashi K, Hata K, Kosaki K, Amagai M.
- Organizer
  49th Annual ESDR Meeting, Bordeaux, FRANCE
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10252
[Presentation] Three genetic variants in TLR1, TIRAP and PSAPL1 are enriched in a specific subgroup of adult atopic dermatitis showing persistent skin manifestation on the face and neck area.2018
- Author(s)
  Fumiyo Yasuda-Sekiguchi, Aiko Shiohama, Hiroshi Kawasaki, Tamotsu Ebihara, Akiharu Kubo, Masayuki Amagai, Takashi Sasaki
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10252
[Presentation] Tmem79 deficient mice sequentially develop dermatitis associated with S.aureus non-dominant and dominant dysbioses.2018
- Author(s)
  Takashi Sasaki, Aiko Shiohama, Keigo Matsuda, Takuji Yamada, Hiroshi Kawasaki, Akiharu Kubo, Masayuki Amagai
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10252
[Presentation] アトピー性皮膚炎患者に対する次亜塩素酸ナトリウム含有浴（Bleach bath）療法が皮膚細菌叢及び臨床症状へ与える影響の検討2017
- Author(s)
  小幡　祥子、川崎　洋、本多　皓、安田文世、塩濱愛子、佐々木貴史、川上英良、天谷雅行、海老原全
- Organizer
  第38回日本炎症再生医学会
- Data Source
  KAKENHI-PROJECT-17K10252
[Presentation] 皮膚炎自然発症モデルマウスflaky tailの皮膚炎原因遺伝子の解明2011
- Author(s)
  塩濱愛子，佐々木貴史，川崎洋，清水厚志，岡野栄之，天谷雅行，工藤純
- Organizer
  日本分子生物学会第34回年会
- Place of Presentation
  パシフィコ横浜（神奈川県）
- Data Source
  KAKENHI-PROJECT-23791290
[Presentation] miRNA生成に関与するDGCR8タンパクの新たな機能2007
- Author(s)
  塩濱愛子
- Organizer
  第30回日本分子生物学会年会・第80回日本生化学会大会合同大会(BMB2007)
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18018037

1. SASAKI Takashi (70306843)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. SHIMIZU Nobuyoshi (50162706)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. SHIMZU Atsushi (30327655)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 久保亮治 (70335256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
5. MATSUI Takeshi (10452442)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 天谷雅行 (90212563)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. ASAKAWA Shuichi (30231872)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. YO Go (10464992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOJIMA Sabinukazuko (10445439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Kawasaki Hiroshi (70445344)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUBO Akiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 梅垣知子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiohama Aiko 塩濱 愛子

SHIOHAMA Aiko 塩濱 愛子

Research Projects

Research Products

Co-Researchers

To Establish a treatment method for the Nagashima-type palmoplantar keratosis based on the fine analysis of genome variation and skin microbiotaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation for mechanism of dermatitis with model mice which develop dermatitis spontaneously with S.aureus proliferation.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The elucidation of the Nagashima-type palmoplantar keratosis caused by SERPINB7 protease inhibitor deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of the pathogenesis of atopic disease by using filaggrin deficient mice in dry environment

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of ma1,candidate responsible gene for atopic dermatitis, andelucidation of molecular mechanism for the dermatitis caused by ma1 deficiencyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of responsible gene for atopic dermatitis in mice modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An Integrated Strategy for Unveiling the Function of KAONASHI Unknown (Functional) Genes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of the developmental process under miRNA and pathogenesis of DiGeorge syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒトゲノム解析から発見した注目すべき8個の新規遺伝子の機能解析と医療への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ヒトゲノム解読から発見した注目すべき8個の新規遺伝子の機能解析と医療への応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

マイクロサテライト配列を利用した微小欠失領域の迅速同定法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A nonepidermolytic keratinocytic epidermal naevus associated with a postzygotic mutation in the gene encoding epidermal growth factor receptor2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal Expansion of Second-Hit Cells with Somatic Recombinations or C>T Transitions Form Porokeratosis in MVD or MVK Mutant Heterozygotes2019

Author(s)

Journal Title

DOI

Shiohama Aiko 塩濱愛子

SHIOHAMA Aiko 塩濱愛子