Takahashi Hayato 高橋勇人

… Alternative Names

TAKAHASHI Hayato 高橋勇人

TAKAHASHI HAYATO 高橋勇人

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Researcher Number	40398615
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 慶應義塾大学, 医学部(信濃町), 准教授 2019 – 2022: 慶應義塾大学, 医学部(信濃町), 講師 2016: 慶應義塾大学, 医学部(信濃町), 講師 2015 – 2016: 慶應義塾大学, 医学部, 講師 2015 – 2016: 慶應義塾大学, 医学部, 専任講師 … More 2013 – 2014: 慶應義塾大学, 医学部, 助教 2007 – 2008: Keio University, School of Medicine, Instructor 2006: 慶應義塾大学, 医学部, 助手 2005: 慶應義塾大学, 医学部, 嘱託(非常勤) Less
Review Section/Research Field	Principal Investigator Dermatology / Medium-sized Section 53:Organ-based internal medicine and related fields Except Principal Investigator Basic Section 53050:Dermatology-related / Dermatology / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 天疱瘡 / T細胞 / 免疫学 / デスモグレイン3 / コレステロール25水酸化酵素 / 炎症収束機構 / 免疫制御機構 / 腫瘍免疫 / コレステロール代謝 / がん免疫療法 … More / 免疫寛容機構 / 自己免疫疾患 / 免疫制御 / 免疫寛容 / 皮膚免疫 / コレステロール25-水酸化酵素 / デスモグレイン / T cell / Desmoglein / Interface dermatitis / T細胞クローン / マウス … More Except Principal Investigator 天疱瘡 / 自己反応性B細胞 / 自己免疫 / 自己抗体 / 自己免疫疾患 / 単一細胞解析 / B細胞 / コレステロール生合成 / 原因遺伝子 / セカンドヒット変異 / 苔癬型免疫反応 / コレステロール / メバロン酸経路 / 前癌状態 / クローン性増殖 / 汗孔角化症 / 細胞競合 / Macrophage-colony stimulating factor / Adenovirus vector / Bone marrow chimera / Mouse model for arthritis / Monocytes / Rheumatoid arthritis / M-Csf / アデノウイルスベクタ / M-CSF / アデノウイルスベクター / 骨髄キメラ / 関節炎モデルマウス / 単球 / 関節リウマチ / デスモグレイン / マウスモデル / 免疫寛容 / 濾胞ヘルパーT細胞 Less

コレステロール代謝を利用した皮膚の新規炎症収束機構の解明Principal Investigator
- Principal Investigator
  
  高橋勇人
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Keio University
Elucidation of mechanism of autoantibody production in pemphigus in conjunction with information from single cell analysis
- Principal Investigator
  
  山上淳
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Tokyo Women's Medical University
Pathophysiology of porokeratosis and cell competition in human
- Principal Investigator
  
  Kubo Akiharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kobe University
  Keio University
Analysis on a new immunoregulatory mechanism to control pathogenic T cell repertoiresPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Hayato
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Keio University
Elucidating pathophysiology of pemphigus by single cell analysis of auto-reactive B cells
- Principal Investigator
  
  Yamagami Jun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Tokyo Women's Medical University
  Keio University
Clarification of peripheral tolerance mechanism involved in the onset of autoimmune skin diseases
- Principal Investigator
  
  Amagai Masayuki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Molecular mechanism of skin inflammation induced by desmoglein 3-specific T cellsPrincipal Investigator
- Principal Investigator
  
  Takahashi Hayato
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Analysis of the activation mechanism of autoreactive B cells in pemphigus
- Principal Investigator
  
  Yamagami Jun
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
ldentification of pathogenicity determining factors of desmoglein3-reactive T cells and evaluation of its blockade therapy.Principal Investigator
- Principal Investigator
  
  TAKAHASHI Hayato
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Examination of a role for circulating monocytes in pathogenesis of rheumatoid arthritis
- Principal Investigator
  
  SETA Noriyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Keio University
天疱瘡モデルマウスを用いた病因的デスモグレイン3反応性T細胞の解析Principal Investigator
- Principal Investigator
  
  高橋勇人
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2017 2016 2015 2014 2009 2008 2007

All Journal Article Presentation Book Patent

[Book] Immunology of the Skin2016
- Author(s)
  Yamagami J, Takahashi H, Amagai M.
- Total Pages
  504
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26253065
[Journal Article] Diverse Role of OX40 on T Cells as a Therapeutic Target for Skin Diseases.2023
- Author(s)
  Iriki H, Takahashi H, Amagai M
- Journal Title
  
  J Invest Dermatol
  
  Volume: 143 Issue: 4 Pages: 545-553
- DOI
  10.1016/j.jid.2022.11.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01051
[Journal Article] Desmoglein-Specific B-Cell-Targeted Single-Cell Analysis Revealing Unique Gene Regulation in Patients with Pemphigus2023
- Author(s)
  Egami Shohei、Watanabe Takashi、Fukushima-Nomura Ayano、Nomura Hisashi、Takahashi Hayato、Yamagami Jun、Ohara Osamu、Amagai Masayuki
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 143 Issue: 10 Pages: 1919-1928
- DOI
  10.1016/j.jid.2023.03.1661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08416
[Journal Article] Clinical Severity scores as a guide for prediction of initial treatment responses in pemphigus and pemphigoid patients.2023
- Author(s)
  Tanaka R, Kurihara Y, Egami S, Saito Y, Ouchi T, Funakoshi T, Takahashi H, Umegaki-Arao N, Kubo A, Tanikawa A, Amagai M, Yamagami J.
- Journal Title
  
  J Dermatol.
  
  Volume: 50 Issue: 2 Pages: 203-211
- DOI
  10.1111/1346-8138.16532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08416
[Journal Article] Rituximab therapy for intractable pemphigus: A multicenter, open-label, single-arm, prospective study of 20 Japanese patients.2023
- Author(s)
  Yamagami J, Kurihara Y, Funakoshi T, Saito Y, Tanaka R, Takahashi H, Ujiie H, Iwata H, Hirai Y, Iwatsuki K, Ishii N, Sakurai J, Abe T, Takemura R, Mashino N, Abe M, Amagai M.
- Journal Title
  
  J Dermatol.
  
  Volume: 50 Issue: 2 Pages: 175-182
- DOI
  10.1111/1346-8138.16597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08416, KAKENHI-PROJECT-22K08419, KAKENHI-PROJECT-21K18227
[Journal Article] T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen2022
- Author(s)
  Takahashi Hayato、Iriki Hisato、Asahina Yasuhiko
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 50 Issue: 2 Pages: 112-123
- DOI
  10.1111/1346-8138.16663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01051
[Journal Article] IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3?Specific B Cell Receptor Knock-in Mouse2022
- Author(s)
  Nomura Hisashi、Wada Naoko、Takahashi Hayato、Kase Yuko、Yamagami Jun、Egami Shohei、Iriki Hisato、Mukai Miho、Kamata Aki、Ito Hiromi、Fujii Hideki、Ishikura Tomoyuki、Koseki Haruhiko、Watanabe Takashi、Yamada Taketo、Ohara Osamu、Koyasu Shigeo、Amagai Masayuki
- Journal Title
  
  The Journal of Immunology
  
  Volume: 208 Issue: 3 Pages: 582-593
- DOI
  10.4049/jimmunol.2100781
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-19H03519
[Journal Article] Peripheral tolerance by Treg via constraining OX40 signal in autoreactive T cells against desmoglein 3, a target antigen in pemphigus2021
- Author(s)
  Iriki H, et al.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 118 Issue: 49
- DOI
  10.1073/pnas.2026763118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22526, KAKENHI-PROJECT-18H04025, KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-21H04801
[Journal Article] Simultaneous detection of mouse Foxp3 and cytosolic fluorescent protein by a modified intracellular staining protocol2021
- Author(s)
  Isami Koichi、Amagai Masayuki、Takahashi Hayato
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 101 Issue: 2 Pages: 147-149
- DOI
  10.1016/j.jdermsci.2020.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H01051
[Journal Article] Cholesterol 25-hydroxylase is a metabolic switch to constrain T cell?mediated inflammation in the skin2021
- Author(s)
  Takahashi H.、Nomura H.、Iriki H.、Kubo A.、Isami K.、Mikami Y.、Mukai M.、Sasaki T.、Yamagami J.、Kudoh J.、Ito H.、Kamata A.、Kurebayashi Y.、Yoshida H.、Yoshimura A.、Sun H. W.、Suematsu M.、O’Shea J. J.、Kanno Y.、Amagai M.
- Journal Title
  
  Science Immunology
  
  Volume: 6 Issue: 64
- DOI
  10.1126/sciimmunol.abb6444
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07627, KAKENHI-PROJECT-21H05044, KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-20H03666
[Journal Article] Analysis of clinical characteristics, prognosis and antibody pathogenicity of pemphigus patients positive for anti‐desmoglein IgG autoantibodies in remission: a retrospective cohort study2021
- Author(s)
  Zhao W.L.、Ishii K.、Egami S.、Xu Z.、Funakoshi T.、Takahashi H.、Tanikawa A.、Ishiko A.、Amagai M.、Yamagami J.
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: 36 Issue: 2 Pages: 271-278
- DOI
  10.1111/jdv.17770
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051, KAKENHI-PROJECT-19H03683
[Journal Article] Pemphigus2017
- Author(s)
  Kasperkiewicz M, Ellebrecht CT, Takahashi H, Yamagami J, Zillikens D, Payne AS, Amagai M
- Journal Title
  
  Nature Reviews Disease Primers
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253065
[Journal Article] Pemphigus2017
- Author(s)
  Michael Kasperkiewicz, Christoph T. Ellebrecht, Hayato Takahashi, Jun Yamagami, Detlef Zillikens, Aimee S. Payne and Masayuki Amagai
- Journal Title
  
  Nature Reviews Disease Primers
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293258
[Journal Article] 天疱瘡におけるデスモグレイン3特異的T細胞の臓器を越えた病原的役割2016
- Author(s)
  高橋勇人, 天谷雅行
- Journal Title
  
  医学のあゆみ
  
  Volume: 259 Pages: 159-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253065
[Journal Article] デスモグレイン3特異的T細胞によって誘導される多彩な皮膚病理2015
- Author(s)
  高橋勇人、天谷雅行
- Journal Title
  
  実験医学
  
  Volume: 33 Pages: 1948-1953
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253065
[Journal Article] 皮膚疾患におけるT細胞の重要な役割2014
- Author(s)
  高橋勇人, 天谷雅行
- Journal Title
  
  実験医学
  
  Volume: 32 Pages: 2854-2860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26253065
[Journal Article] A Single Helper T cell Clone Is Sufficient to Commit Polyclonal Naive B cells to Produce Pathogenic IgG in Experimental Pemphigus Vulgaris2009
- Author(s)
  Takahashi H, Kuwana M, Amagai M
- Journal Title
  
  J Immunol 182(3)
  
  Pages: 1740-1745
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790801
[Journal Article] Novel System Evaluating In Vivo Pathogenicity of Desmoglein 3-Reactive T-Cell Clones Using Murine Pemphigus Vulgaris2008
- Author(s)
  Takahashi H, Amagai M, Nishikawa T, Fujii Y, Kawakami Y, Kuwana M
- Journal Title
  
  J Immunol 181(2)
  
  Pages: 1526-1535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790801
[Journal Article] Genetic characterization of human Dsg3-specific B cells isolated by flow cytometry from the peripheral blood of patients with pemphigus vulgaris2008
- Author(s)
  Yamagami J, Takahashi H, Ota T, Amagai M.
- Journal Title
  
  J Dermatol Sci 52
  
  Pages: 98-107
- NAID
  10024457486
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790801
[Journal Article] Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine nemohieus vulgaris2008
- Author(s)
  Takahashi H, Amagai M, Nishikawa T, Fuiii Y, Kawakami Y, Kuwana M
- Journal Title
  
  J Immunol 181
  
  Pages: 1526-1535
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790801
[Journal Article] T Helper Type 2-Biased Natural Killer Cell Phenotype in Patients with Pemphigus Vulgaris.2007
- Author(s)
  Takahashi H, Amagai M, Tanikawa A, Suzuki S, Ikeda Y, Nishikawa T, Kawakami Y, Kuwana M
- Journal Title
  
  J Invest Dermatol 127・2
  
  Pages: 324-330
- Data Source
  KAKENHI-PROJECT-17790781
[Patent] ２５－ヒドロキシコレステロールを有効成分として含有してなる、活性化されたＴ細胞及び／又はＢ細胞に選択的な細胞死誘導剤又は細胞死促進剤2016
- Inventor(s)
  高橋勇人、天谷雅行
- Industrial Property Rights Holder
  高橋勇人、天谷雅行
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-111556
- Filing Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-26293258
[Presentation] IFNg signaling plays both pro-inflammatory and immunoregulatory roles depending on the cell types in mouse dermatitis model2021
- Author(s)
  Mukai M, Takahashi H, Amagai M
- Organizer
  The 50th Annual Meeting of the Japanese Society for Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051
[Presentation] IFN-gamma signaling is pro-inflammatory in T cells but immunoregulatory in non-T and B cell population in interface dermatitis model2021
- Author(s)
  Miho Mukai, Hayato Takahashi, Masayuki Amagai
- Organizer
  The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051
[Presentation] Autoantigen-specific B cells targeted single-cell RNA-seq reveals the functional heterogeneity in pemphigus patients2021
- Author(s)
  Shohei Egami, Takashi Watanabe, Ayano Nomura-Fukushima, Hisashi Nomura, Hayato Takahashi, Jun Yamagami, John R Stanley, Osamu Ohara, Masayuki Amagai
- Organizer
  The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051
[Presentation] Immunoregulatory roles of IFN-gamma signaling in non-T and B cell population is important for suppression of interface dermatitis in mouse2021
- Author(s)
  Miho Mukai, Hayato Takahashi, Masayuki Amagai
- Organizer
  2021 Society for Investigative Dermatology Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051
[Presentation] 天疱瘡モデルマウスの抗デスモグレイン3抗体産生においてIL-27p28は重要な役割を果たす2020
- Author(s)
  鎌田亜紀, 高橋勇人, 吉田裕樹, 伊藤宏美, 山上淳, 天谷雅行
- Organizer
  第41回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-19H01051
[Presentation] IL-27 plays an important role in anti-desmoglein 3 antibody production in pemphigus vulgaris mouse model.2020
- Author(s)
  Aki Kamata, Hayato Takahashi, Hiroki Yoshida, Jun Yamagami, Masayuki Amagai
- Organizer
  The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051
[Presentation] Single-cell RNA-seq reveals the transcriptional landscape and heterogeneity of auto reactive B cells in pemphigus patients2019
- Author(s)
  Shohei Egami, Takashi Watanabe, Hisashi Nomura, Hayato Takahashi, Jun Yamagami, Osamu Ohara, Masayuki Amagai
- Organizer
  44th JSID annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03683
[Presentation] T cell-mediated, OX40-dependent peripheral tolerance to autoantigen, desmoglein 32019
- Author(s)
  Hisato Iriki, Hayato Takahashi, Naoko Wada, Shohei Hori, Masayuki Amagai:
- Organizer
  77th Annual Meeting, Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H01051
[Presentation] Novel immune regulation by CD4+ T cells via cholesterol 25-hydroxylase pathway.2017
- Author(s)
  Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Akiko Kubo, Yohei Mikami, Yuka Kanno, John O’Shea, Masayuki Amagai
- Organizer
  第24回分子皮膚科学フォーラム
- Place of Presentation
  ベルサール東京日本橋（東京都中央区）
- Year and Date
  2017-04-14
- Data Source
  KAKENHI-PROJECT-26293258
[Presentation] FcgRllb is critical to establish clonal ignorance and suppress pemphigus phenotype in pathogenic anti-desmoglein 3 antibody knock-in mice2016
- Author(s)
  Nomura H, Kase Y, Yamagami J, Wada N, Koyasu S, Takahashi H, Amagai M
- Organizer
  41st Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  仙台国際センター（宮城県仙台市青葉区）
- Year and Date
  2016-12-09
- Data Source
  KAKENHI-PROJECT-26253065
[Presentation] 25-hydroxycholesterol secreted from CD4+ T cells mediates novel immune regulation by interleukin-272016
- Author(s)
  Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Yohei Mikami, Yuka Kanno, John O’Shea, Masayuki Amagai
- Organizer
  The 45th annual meeting of the Japanese Society for Immunology
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26293258
[Presentation] Novel immune regulation by CD4+ T cells via cholesterol 25-hydroxylase pathway.2016
- Author(s)
  Takahashi H, Nomura H, Iriki H, Mikami Y, Kanno Y, Kubo A, O'shea J, Amagai M
- Organizer
  46th Annual Meeting of the European Society for Dermatological Research
- Place of Presentation
  Munich, Germany
- Year and Date
  2016-09-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253065
[Presentation] Novel immune regulation by CD4+ T cells via cholesterol 25-hydroxylase pathway.2016
- Author(s)
  Hayato Takahashi, Hisashi Nomura, Hisato Iriki, Akiko Kubo, Yohei Mikami, Yuka Kanno, John O’Shea, Masayuki Amagai
- Organizer
  European Society for Dermatological Research Annual Meeting 2016
- Place of Presentation
  ミュンヘン（ドイツ）
- Year and Date
  2016-09-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293258
[Presentation] stablishment of thymus transplant model to analyze peripheral T cell tolerance against pemphigus autoantigen, desmoglein 32015
- Author(s)
  Iriki H, Takahashi H, Wada N, Amagai M
- Organizer
  The 44th Annual Meeting of the Japanese Society for Immunology
- Place of Presentation
  Sapporo Convention Center (Sapporo City, Hokkaido, Japan)
- Year and Date
  2015-11-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253065
[Presentation] Intravenous immunoglobulin regulates anti-desmoglein 3 autoantibody production in B220- antibody-producing cells in mice with pemphigus vulgaris2015
- Author(s)
  Kase Y, Yamagami J, Wada N, Takahashi H, Koyasu S, Amagai M
- Organizer
  45th Annual Meeting of the European Society for Dermatological Research
- Place of Presentation
  Rotterdam (The Netherlands)
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253065
[Presentation] デスモグレイン3反応性T細胞クローンは多クローンlgG型抗Dsg3抗体産生を謬導する2008
- Author(s)
  高橋勇人、桑名正隆、天谷雅行
- Organizer
  第822回日本庫膚科学会東京地方会
- Place of Presentation
  東京
- Year and Date
  2008-12-20
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] デスモグレイン3反応性T細胞クローンは多クローンIgG型抗Dsg3抗体産生を誘導する2008
- Author(s)
  高橋勇人、桑名正隆、天谷雅行
- Organizer
  第822回日本皮膚科学会東京地方会
- Place of Presentation
  東京
- Year and Date
  2008-12-20
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] Dsg3-reactive T cells ; a key player in the autoantibody production in pemphigus2008
- Author(s)
  Hayato Takahashi、Masataka Kuwana、Masayuki Amagai
- Organizer
  International Meeting on Autoimmune Bullous Disease
- Place of Presentation
  Otsu, Japan
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] 天疱瘡モデルマウスにおいて、デスモグレイン3反応性T細胞クローンは多クローンIgG型抗デスモグレイン3抗体産生を誘導する2008
- Author(s)
  高橋勇人、桑名正隆、天谷雅行
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] Single desmoglein 3-reactive CD4+ T cell clones activate polyclonal naive B cells and promote the production of pathogenic IgG in experimental pemphigus vulgaris2008
- Author(s)
  Hayato Takahashi、Masataka Kuwana、Masayuki Amagai
- Organizer
  International Investigative Dermatology2008
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2008-05-17
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] Single desmoglein 3-reactive CD4^+ T cell clones activate polyclonal naive B cells and promote the production of pathogenic IgG in experimental nemnhigus vulearis2008
- Author(s)
  Havato Takahashi, Masataka Kuwana, Masayuki Amagai
- Organizer
  International Investigative Dermatology 2008
- Place of Presentation
  京都
- Year and Date
  2008-05-14
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] 天疱瘡モデルマウスにおいて、デスモグレイン3反応性T細胞クローンは多クローンlgG型抗デスモグレイン3抗体産生を誘導する2008
- Author(s)
  高橋勇人、桑名正隆、天谷雅行
- Organizer
  第38回日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] Dsg3-reactive T cells ; a key player in the autoantibody production in pe mphigus2008
- Author(s)
  Havato Takahashi, Masataka Kuwana, Masayuki Amagai
- Organizer
  International Meeting on Autoimmune Bullous Disease
- Place of Presentation
  大津
- Year and Date
  2008-05-18
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] Interleukin-4 as a critical mediator derived from desmoglein 3-reactive T cells in the mouse pemphigus vulgaris model2007
- Author(s)
  Hayato Takahashi、Masayuki Amagai、Takeji Nishikawa、Yutaka Kawakami、Masataka Kuwana
- Organizer
  The 37th annual meeting of the Japanese Society for Immunology
- Place of Presentation
  Tokyo
- Year and Date
  2007-11-20
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] A novel system for evaluation of in vivo pathogenicity of desmoglein3-reactive T cell clones: a critical role of interleukin-4 in the mousepemphigus vulgaris model2007
- Author(s)
  Hayato Takahashi, et. a1.
- Organizer
  The Society for Investigative Dermatology68th Annual Meeting
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] A novel system for evaluation of in vivo pathogenicity of desmoglein 3-reactive T cell clones : a critical role of interleukin-4 in the mouse pemphigus vulgaris model2007
- Author(s)
  Hayato Takahashi、Masayuki Amagai、Takeji Nishikawa、Yutaka Kawakami、Masataka Kuwana
- Organizer
  The Society for Investigative Dermatology 68th Annual Meeting
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2007-05-12
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] Interleukin-4 as a critical mediator derived from desmoglein 3-reactive T cells in the mouse pemphigus vulgaris model2007
- Author(s)
  Hayato Takahashi, et. a1.
- Organizer
  The 37th annual meeting of the Japanese Societyfor Immunology
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] 天疱瘡モデルマウスを用いた自己反応性T細胞株のin vivo病原性評価法の確立2007
- Author(s)
  高橋勇人、天谷雅行、西川武二、桑名正隆
- Organizer
  第816回東京支部研究地方会
- Place of Presentation
  東京
- Year and Date
  2007-02-15
- Data Source
  KAKENHI-PROJECT-19790801
[Presentation] 天疱瘡モデルマウスを用いた自己反応性T細胞株の仙丙9病原性評価法の確立2007
- Author(s)
  高橋勇人, 他3名
- Organizer
  第816回東京支部研究地方会
- Place of Presentation
  東京
- Year and Date
  2007-12-15
- Data Source
  KAKENHI-PROJECT-19790801

1. Yamagami Jun (80327618)

# of Collaborated Projects: 5 results

# of Collaborated Products: 13 results
2. AMAGAI MASAYUKI (90212563)

# of Collaborated Projects: 3 results

# of Collaborated Products: 13 results
3. 谷口智憲 (40424163)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SETA Noriyuki (40338372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KUWANA Masataka (50245479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Kubo Akiharu (70335256)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐々木貴史 (70306843)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 福本毅 (80778770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 藤田春美 (30736971)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 舩越建 (80365353)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 渡辺貴志 (50406815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 有田誠 (80292952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 福田桂太郎 (60464848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. O'Shea John

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 吉田裕樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Hayato 高橋 勇人

TAKAHASHI Hayato 高橋 勇人

TAKAHASHI HAYATO 高橋 勇人

Research Projects

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Co-Researchers

コレステロール代謝を利用した皮膚の新規炎症収束機構の解明Principal Investigator

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Elucidation of mechanism of autoantibody production in pemphigus in conjunction with information from single cell analysis

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Pathophysiology of porokeratosis and cell competition in human

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Analysis on a new immunoregulatory mechanism to control pathogenic T cell repertoiresPrincipal Investigator

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Elucidating pathophysiology of pemphigus by single cell analysis of auto-reactive B cells

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Clarification of peripheral tolerance mechanism involved in the onset of autoimmune skin diseases

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Molecular mechanism of skin inflammation induced by desmoglein 3-specific T cellsPrincipal Investigator

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Analysis of the activation mechanism of autoreactive B cells in pemphigus

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ldentification of pathogenicity determining factors of desmoglein3-reactive T cells and evaluation of its blockade therapy.Principal Investigator

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Examination of a role for circulating monocytes in pathogenesis of rheumatoid arthritis

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天疱瘡モデルマウスを用いた病因的デスモグレイン3反応性T細胞の解析Principal Investigator

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[Book] Immunology of the Skin2016

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Total Pages

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Data Source

[Journal Article] Diverse Role of OX40 on T Cells as a Therapeutic Target for Skin Diseases.2023

Author(s)

Journal Title

Takahashi Hayato 高橋勇人

TAKAHASHI Hayato 高橋勇人

TAKAHASHI HAYATO 高橋勇人