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Tohmonda Takahide  東門田 誠一

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TAKAHIDE Tohmonda  東門田 誠一

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Researcher Number 40415237
Other IDs
Affiliation (Current) 2025: 尚絅学院大学, 総合人間科学系, 准教授
Affiliation (based on the past Project Information) *help 2018: 尚絅学院大学, 総合人間科学系, 准教授
2016 – 2017: 尚絅学院大学, 総合人間科学部, 准教授
2014 – 2015: 慶應義塾大学, 医学部, 助教
2012 – 2015: 慶應義塾大学, 医学部, 特任助教
2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Orthopaedic surgery
Except Principal Investigator
Orthopaedic surgery
Keywords
Principal Investigator
小胞体ストレス / XBP1 / 筋骨格系 / 骨軟骨代謝 / 骨代謝 / 骨芽細胞 / 破骨細胞
Except Principal Investigator
造血制御 / TACE/ADAM10 / 小胞体ストレス応答 … More / ADAM17 / ADAM10 / 骨代謝 / 小胞体ストレス / ADAM遺伝子 / 筋代謝 / 骨軟骨代謝 Less
  • Research Projects

    (3 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (12 People)
  •  The role of UPR in preservation of skeletal musclePrincipal Investigator

    • Principal Investigator
      Tohmonda Takahide
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Shokei Gakuin College
  •  Functional analysis of ADAMs in the musculoskeletal and hematopoietic system

    • Principal Investigator
      Horiuchi Keisuke
    • Project Period (FY)
      2012 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Keio University
  •  ER stress-mediated regulation of osteoclast differentiationPrincipal Investigator

    • Principal Investigator
      TAKAHIDE Tohmonda
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Keio University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.2018

    • Author(s)
      Odaka YS, Tohmonda T, Toyoda A, Aruga J.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 14954-14954

    • DOI

      10.1038/s41598-018-33235-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16K10836
  • [Journal Article] Identification and characterization of novel conserved domains in metazoan Zic proteins.2018

    • Author(s)
      Tohmonda, T., Kamiya, A., Ishiguro, A., Iwaki, T., Fujimi, T.J., Hatayama, M., Aruga, J.
    • Journal Title

      Mol Biol Evol

      Volume: 35 Issue: 9 Pages: 2205-2229

    • DOI

      10.1093/molbev/msy122

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16K10836
  • [Journal Article] Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass2016

    • Author(s)
      Hirozane T, Tohmonda T, Yoda M, Shimoda M, Kanai Y, Matsumoto M, Morioka H, Nakamura M, Horiuchi K.
    • Journal Title

      Scientific Reports

      Volume: - Issue: 1 Pages: 34426-34426

    • DOI

      10.1038/srep34426

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16J02900, KAKENHI-PROJECT-16K10836
  • [Journal Article] The unfolded protein response in skeletal development and homeostasis2016

    • Author(s)
      Horiuchi K, Tohmonda T, Morioka H
    • Journal Title

      Cell and Molecular Life Science

      Volume: na Issue: 15 Pages: 2851-69

    • DOI

      10.1007/s00018-016-2178-1

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-16K10836
  • [Journal Article] Corrigendum: Novel method for immunofluorescence staining of mammalian eggs using non-contact alternating- current electric- field mixing of microdroplets.2016

    • Author(s)
      Shirasawa H, Kumagai J, Sato E, Kabashima K, Kumazawa Y, Sato W, Miura H, Nakamura R, Nanjo H, Minamiya Y, Akagami Y, Terada Y.
    • Journal Title

      Scientic Reports

      Volume: 7 Issue: 1 Pages: 6-6

    • DOI

      10.1038/srep41552

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462473, KAKENHI-PROJECT-16K10836
  • [Journal Article] IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis2015

    • Author(s)
      Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K.
    • Journal Title

      J Clin Investigation

      Volume: 125(8) Issue: 8 Pages: 3269-79

    • DOI

      10.1172/jci76765

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-24390358
  • [Journal Article] Generation and characterization of a novel shoulder contracture mouse model2015

    • Author(s)
      Oki S, Shirasawa H, Yoda M, Matsumura N, Tohmonda T, Yuasa K, Nakamura M, Matsumoto M, Horiuchi K
    • Journal Title

      Journal of Orthopeadic Research

      Volume: 33 Issue: 11 Pages: 1732-8

    • DOI

      10.1002/jor.22943

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390358
  • [Journal Article] A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool2015

    • Author(s)
      Mizuno S, Yoda M, Shimoda M, Tohmonda T, Okada Y, Toyama Y, Takeda S, Nakamura M, Matsumoto M, Horiuchi K.
    • Journal Title

      Journal of Biological chemistry

      Volume: 290 Issue: 47 Pages: 28456-64

    • DOI

      10.1074/jbc.m115.653477

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-25282202
  • [Journal Article] ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.2014

    • Author(s)
      Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, Horiuchi K
    • Journal Title

      Cytokine

      Volume: 71 Issue: 2 Pages: 238-245

    • DOI

      10.1016/j.cyto.2014.10.032

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-24791566
  • [Journal Article] The IRE1alpha-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis2013

    • Author(s)
      Tohmonda, T., et al.
    • Journal Title

      J Biol Chem

      Volume: 288 Issue: 3 Pages: 1691-1695

    • DOI

      10.1074/jbc.c112.424606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-24791566
  • [Presentation] IRE1a-XBP1経路を基軸とした骨代謝制御2017

    • Author(s)
      東門田 誠一
    • Organizer
      第40回日本分子生物学会、生命科学系学会合同年次大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K10836
  • [Presentation] 骨芽細胞における不良蛋白質応答は副甲状腺受容体の発現を制御する2013

    • Author(s)
      東門田誠一
    • Organizer
      第86回日本整形外科学会学術集会
    • Place of Presentation
      広島グリーンアリーナ、広島リーガロイヤルホテル、NTTクレドホール、メルパルク広島(広島県)
    • Data Source
      KAKENHI-PROJECT-24791566
  • [Presentation] 骨芽細胞における不良蛋白質応答は副甲状腺受容体の発現を制御する2013

    • Author(s)
      東門田 誠一
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島
    • Data Source
      KAKENHI-PROJECT-24390358
  • [Presentation] The IRE1alpha-XBP1 pathway induces osteoclast differentiation via promoting transcription of Nfatc12013

    • Author(s)
      東門田誠一
    • Organizer
      The 5th EMBO meeting 2013
    • Place of Presentation
      アムステルダム(オランダ)
    • Data Source
      KAKENHI-PROJECT-24791566
  • [Presentation] 小胞体ストレス応答機構IRE1α-XBP1経路は新規の破骨細胞分化制御機構である2013

    • Author(s)
      東門田誠一
    • Organizer
      第14回運動器科学研究会
    • Place of Presentation
      汐留コンファレンスセンター(東京都)
    • Data Source
      KAKENHI-PROJECT-24791566
  • [Presentation] The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis2012

    • Author(s)
      Takahide Tohmonda, Yoshiaki Toyama,Keisuke Horiuchi
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡・福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-24791566
  • [Presentation] BMP2を用いた骨芽細胞分化系において, XBP1はPTh/PTHRレセプターの発現を正に制御する2012

    • Author(s)
      東門田誠一
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-24390358
  • [Presentation] IRE1α-XBP1経路は、骨芽細胞におけるPTH/PTHrPレセプターの発現を直接制御する2012

    • Author(s)
      東門田誠一、戸山芳昭、堀内圭輔
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京・京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-24791566
  • [Presentation] 骨芽細胞分化における小胞体ストレス応答機構IRE1α-XBP1経路の機能解析2012

    • Author(s)
      堀内圭輔、東門田誠一、戸山芳昭
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      東京・京王プラザホテル
    • Invited
    • Data Source
      KAKENHI-PROJECT-24791566
  • [Presentation] 破骨細胞分化におけるIRE1α-XBP1経路の機能解析

    • Author(s)
      東門田 誠一, 依田 昌樹, 松本 守雄, 戸山 芳昭, 堀内 圭輔
    • Organizer
      第32回日本骨代謝学会学
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24 – 2014-07-26
    • Data Source
      KAKENHI-PROJECT-24390358
  • [Presentation] 不良タンパク質応答に機能するIRE1α-XBP1経路は新規の破骨細胞分化誘導因子である

    • Author(s)
      堀内 圭輔, 東門田 誠一, 依田 昌樹, 松本 守雄, 戸山 芳昭
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-09 – 2014-10-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-24390358
  • [Presentation] マウスを利用した新規肩関節拘縮モデルの作成およびその分子生物学的評価

    • Author(s)
      大木 聡, 依田 昌樹, 木場 健, 東門田 誠一, 松村 昇, 戸山 芳昭, 堀内 圭輔
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-09 – 2014-10-10
    • Data Source
      KAKENHI-PROJECT-24390358
  • [Presentation] 廃用性筋萎縮における小胞体ストレス応答の機能解析

    • Author(s)
      木場 健, 湯浅 和樹, 東門田 誠一, 戸山 芳昭, 中村 雅也, 堀内 圭輔
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-09 – 2014-10-10
    • Data Source
      KAKENHI-PROJECT-24390358
  • [Presentation] 破骨細胞分化におけるIRE1α-XBP1経路の機能解析

    • Author(s)
      東門田誠一、依田昌樹、松本守雄、戸山芳昭、堀内圭輔
    • Organizer
      第32回 日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-07-24 – 2014-07-26
    • Data Source
      KAKENHI-PROJECT-24791566
  • 1.  Horiuchi Keisuke (30327564)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 2.  YODA Masaki (30464994)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 3.  TOYAMA Yoshiaki (40129549)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 4.  HATAYAMA Minoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  SATO Naoki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  KUMAGAI Jin
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  有賀 純
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 8.  御子柴 克彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  白澤 弘光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  椛嶋 克哉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  寺田 幸弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  佐藤 亘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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