Tohmonda Takahide 東門田誠一

… Alternative Names

TAKAHIDE Tohmonda 東門田誠一

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Researcher Number	40415237
Other IDs
Affiliation (Current)	2025: 尚絅学院大学, 総合人間科学系, 准教授
Affiliation (based on the past Project Information) *help	2018: 尚絅学院大学, 総合人間科学系, 准教授 2016 – 2017: 尚絅学院大学, 総合人間科学部, 准教授 2014 – 2015: 慶應義塾大学, 医学部, 助教 2012 – 2015: 慶應義塾大学, 医学部, 特任助教 2012: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Orthopaedic surgery Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 小胞体ストレス / XBP1 / 筋骨格系 / 骨軟骨代謝 / 骨代謝 / 骨芽細胞 / 破骨細胞 Except Principal Investigator 造血制御 / TACE/ADAM10 / 小胞体ストレス応答 … More / ADAM17 / ADAM10 / 骨代謝 / 小胞体ストレス / ADAM遺伝子 / 筋代謝 / 骨軟骨代謝 Less

The role of UPR in preservation of skeletal musclePrincipal Investigator
- Principal Investigator
  
  Tohmonda Takahide
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shokei Gakuin College
Functional analysis of ADAMs in the musculoskeletal and hematopoietic system
- Principal Investigator
  
  Horiuchi Keisuke
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
ER stress-mediated regulation of osteoclast differentiationPrincipal Investigator
- Principal Investigator
  
  TAKAHIDE Tohmonda
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University

All 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.2018
- Author(s)
  Odaka YS, Tohmonda T, Toyoda A, Aruga J.
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 14954-14954
- DOI
  10.1038/s41598-018-33235-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16K10836
[Journal Article] Identification and characterization of novel conserved domains in metazoan Zic proteins.2018
- Author(s)
  Tohmonda, T., Kamiya, A., Ishiguro, A., Iwaki, T., Fujimi, T.J., Hatayama, M., Aruga, J.
- Journal Title
  
  Mol Biol Evol
  
  Volume: 35 Issue: 9 Pages: 2205-2229
- DOI
  10.1093/molbev/msy122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H04666, KAKENHI-PROJECT-16K10836
[Journal Article] Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass2016
- Author(s)
  Hirozane T, Tohmonda T, Yoda M, Shimoda M, Kanai Y, Matsumoto M, Morioka H, Nakamura M, Horiuchi K.
- Journal Title
  
  Scientific Reports
  
  Volume: － Issue: 1 Pages: 34426-34426
- DOI
  10.1038/srep34426
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J02900, KAKENHI-PROJECT-16K10836
[Journal Article] The unfolded protein response in skeletal development and homeostasis2016
- Author(s)
  Horiuchi K, Tohmonda T, Morioka H
- Journal Title
  
  Cell and Molecular Life Science
  
  Volume: na Issue: 15 Pages: 2851-69
- DOI
  10.1007/s00018-016-2178-1
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-16K10836
[Journal Article] Corrigendum: Novel method for immunofluorescence staining of mammalian eggs using non-contact alternating- current electric- field mixing of microdroplets.2016
- Author(s)
  Shirasawa H, Kumagai J, Sato E, Kabashima K, Kumazawa Y, Sato W, Miura H, Nakamura R, Nanjo H, Minamiya Y, Akagami Y, Terada Y.
- Journal Title
  
  Scientic Reports
  
  Volume: 7 Issue: 1 Pages: 6-6
- DOI
  10.1038/srep41552
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462473, KAKENHI-PROJECT-16K10836
[Journal Article] IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis2015
- Author(s)
  Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K.
- Journal Title
  
  J Clin Investigation
  
  Volume: 125(8) Issue: 8 Pages: 3269-79
- DOI
  10.1172/jci76765
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25221002, KAKENHI-PROJECT-24390358
[Journal Article] Generation and characterization of a novel shoulder contracture mouse model2015
- Author(s)
  Oki S, Shirasawa H, Yoda M, Matsumura N, Tohmonda T, Yuasa K, Nakamura M, Matsumoto M, Horiuchi K
- Journal Title
  
  Journal of Orthopeadic Research
  
  Volume: 33 Issue: 11 Pages: 1732-8
- DOI
  10.1002/jor.22943
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358
[Journal Article] A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool2015
- Author(s)
  Mizuno S, Yoda M, Shimoda M, Tohmonda T, Okada Y, Toyama Y, Takeda S, Nakamura M, Matsumoto M, Horiuchi K.
- Journal Title
  
  Journal of Biological chemistry
  
  Volume: 290 Issue: 47 Pages: 28456-64
- DOI
  10.1074/jbc.m115.653477
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-25282202
[Journal Article] ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.2014
- Author(s)
  Uchikawa S, Yoda M, Tohmonda T, Kanaji A, Matsumoto M, Toyama Y, Horiuchi K
- Journal Title
  
  Cytokine
  
  Volume: 71 Issue: 2 Pages: 238-245
- DOI
  10.1016/j.cyto.2014.10.032
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-24791566
[Journal Article] The IRE1alpha-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis2013
- Author(s)
  Tohmonda, T., et al.
- Journal Title
  
  J Biol Chem
  
  Volume: 288 Issue: 3 Pages: 1691-1695
- DOI
  10.1074/jbc.c112.424606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390358, KAKENHI-PROJECT-24791566
[Presentation] IRE1a-XBP1経路を基軸とした骨代謝制御2017
- Author(s)
  東門田　誠一
- Organizer
  第40回日本分子生物学会、生命科学系学会合同年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K10836
[Presentation] 骨芽細胞における不良蛋白質応答は副甲状腺受容体の発現を制御する2013
- Author(s)
  東門田誠一
- Organizer
  第86回日本整形外科学会学術集会
- Place of Presentation
  広島グリーンアリーナ、広島リーガロイヤルホテル、NTTクレドホール、メルパルク広島（広島県）
- Data Source
  KAKENHI-PROJECT-24791566
[Presentation] 骨芽細胞における不良蛋白質応答は副甲状腺受容体の発現を制御する2013
- Author(s)
  東門田誠一
- Organizer
  第86回日本整形外科学会学術総会
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] The IRE1alpha-XBP1 pathway induces osteoclast differentiation via promoting transcription of Nfatc12013
- Author(s)
  東門田誠一
- Organizer
  The 5th EMBO meeting 2013
- Place of Presentation
  アムステルダム（オランダ）
- Data Source
  KAKENHI-PROJECT-24791566
[Presentation] 小胞体ストレス応答機構IRE1α-XBP1経路は新規の破骨細胞分化制御機構である2013
- Author(s)
  東門田誠一
- Organizer
  第1４回運動器科学研究会
- Place of Presentation
  汐留コンファレンスセンター（東京都）
- Data Source
  KAKENHI-PROJECT-24791566
[Presentation] The IRE1α-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis2012
- Author(s)
  Takahide Tohmonda, Yoshiaki Toyama,Keisuke Horiuchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡・福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24791566
[Presentation] BMP2を用いた骨芽細胞分化系において, XBP1はPTh/PTHRレセプターの発現を正に制御する2012
- Author(s)
  東門田誠一
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Year and Date
  2012-12-14
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] IRE1α-XBP1経路は、骨芽細胞におけるPTH/PTHrPレセプターの発現を直接制御する2012
- Author(s)
  東門田誠一、戸山芳昭、堀内圭輔
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京・京王プラザホテル
- Data Source
  KAKENHI-PROJECT-24791566
[Presentation] 骨芽細胞分化における小胞体ストレス応答機構IRE1α-XBP1経路の機能解析2012
- Author(s)
  堀内圭輔、東門田誠一、戸山芳昭
- Organizer
  第30回日本骨代謝学会学術集会
- Place of Presentation
  東京・京王プラザホテル
- Invited
- Data Source
  KAKENHI-PROJECT-24791566
[Presentation] 破骨細胞分化におけるIRE1α-XBP1経路の機能解析
- Author(s)
  東門田誠一, 依田昌樹, 松本守雄, 戸山芳昭, 堀内圭輔
- Organizer
  第32回日本骨代謝学会学
- Place of Presentation
  大阪
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 不良タンパク質応答に機能するIRE1α-XBP1経路は新規の破骨細胞分化誘導因子である
- Author(s)
  堀内圭輔, 東門田誠一, 依田昌樹, 松本守雄, 戸山芳昭
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Invited
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] マウスを利用した新規肩関節拘縮モデルの作成およびその分子生物学的評価
- Author(s)
  大木聡, 依田昌樹, 木場健, 東門田誠一, 松村昇, 戸山芳昭, 堀内圭輔
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 廃用性筋萎縮における小胞体ストレス応答の機能解析
- Author(s)
  木場健, 湯浅和樹, 東門田誠一, 戸山芳昭, 中村雅也, 堀内圭輔
- Organizer
  第29回日本整形外科学会基礎学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-09 – 2014-10-10
- Data Source
  KAKENHI-PROJECT-24390358
[Presentation] 破骨細胞分化におけるIRE1α-XBP1経路の機能解析
- Author(s)
  東門田誠一、依田昌樹、松本守雄、戸山芳昭、堀内圭輔
- Organizer
  第３２回　日本骨代謝学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-07-24 – 2014-07-26
- Data Source
  KAKENHI-PROJECT-24791566

1. Horiuchi Keisuke (30327564)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. YODA Masaki (30464994)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. TOYAMA Yoshiaki (40129549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. HATAYAMA Minoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. SATO Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. KUMAGAI Jin

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 有賀純

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 御子柴克彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 白澤弘光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 椛嶋克哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 寺田幸弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 佐藤亘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tohmonda Takahide 東門田 誠一

TAKAHIDE Tohmonda 東門田 誠一

Research Projects

Research Products

Co-Researchers

The role of UPR in preservation of skeletal musclePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of ADAMs in the musculoskeletal and hematopoietic system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ER stress-mediated regulation of osteoclast differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification and characterization of novel conserved domains in metazoan Zic proteins.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The unfolded protein response in skeletal development and homeostasis2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Corrigendum: Novel method for immunofluorescence staining of mammalian eggs using non-contact alternating- current electric- field mixing of microdroplets.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation and characterization of a novel shoulder contracture mouse model2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Disintegrin and Metalloprotease 10 (ADAM10) Is Indispensable for Maintenance of the Muscle Satellite Cell Pool2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ADAM17 regulates IL-1 signaling by selectively releasing IL-1 receptor type 2 from the cell surface.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The IRE1alpha-XBP1 pathway positively regulates parathyroid hormone (PTH)/PTH-related peptide receptor expression and is involved in pth-induced osteoclastogenesis2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] IRE1a-XBP1経路を基軸とした骨代謝制御2017

Author(s)

Organizer

Data Source

[Presentation] 骨芽細胞における不良蛋白質応答は副甲状腺受容体の発現を制御する2013

Author(s)

Organizer

Tohmonda Takahide 東門田誠一

TAKAHIDE Tohmonda 東門田誠一