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Morihara Hirofumi  森原 啓文

ORCIDConnect your ORCID iD *help
Researcher Number 40802674
Other IDs
Affiliation (Current) 2025: 大阪医科薬科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2021 – 2024: 大阪医科薬科大学, 医学部, 助教
2019 – 2020: 大阪医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 47040:Pharmacology-related / Basic Section 49010:Pathological biochemistry-related
Except Principal Investigator
Basic Section 55030:Cardiovascular surgery-related / Basic Section 47060:Clinical pharmacy-related
Keywords
Principal Investigator
iPS細胞 / 液胞型プロトンATPase / 分子標的治療薬 / 薬剤起因性心臓障害 / mTOR / ハイスループットスクリーニング / ライソゾーム / ファブリー病 / ライソゾーム病
Except Principal Investigator
大動脈解離 … More / 血管細胞モデル / 遺伝性結合組織疾患 / 人工多能性幹細胞 / Marfan症候群 / 薬剤起因性心臓障害 / がん / 心臓機能障害 / 分子標的治療薬 / iPS細胞 Less
  • Research Projects

    (4 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (5 People)
  •  第3世代 EGFR チロシンキナーゼ阻害薬による心毒性と V-ATPase の関係性についてPrincipal Investigator

    • Principal Investigator
      森原 啓文
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 47040:Pharmacology-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  がん分子標的治療薬起因性心臓機能障害モデル樹立とメカニズム解析

    • Principal Investigator
      藤阪 保仁
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47060:Clinical pharmacy-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  The cell-based vascular model with the inducible pluripotent stem cells of Marfan syndrome.

    • Principal Investigator
      大門 雅広
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55030:Cardiovascular surgery-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
  •  Elucidation of the pathological role of vacuolar ATPase in lysosomal storage diseasesPrincipal Investigator

    • Principal Investigator
      Morihara Hirofumi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Osaka Medical and Pharmaceutical University

All 2022 2020 2019

All Journal Article Presentation

  • [Journal Article] Intravenously Injected Pluripotent Stem Cell-derived Cells Form Fetomaternal Vasculature and Prevent Miscarriage in Mouse2020

    • Author(s)
      Daimon Atsushi, Morihara Hirofumi, Tomoda Kiichiro, Morita Natsuko, Koishi Yoshinori, Kanki Kazuyoshi, Ohmichi Masahide, Asahi Michio
    • Journal Title

      Cell Transplantation

      Volume: 29 Pages: 096368972097045-096368972097045

    • DOI

      10.1177/0963689720970456

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K16546
  • [Journal Article] Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is dependent on its time of administration in mice2020

    • Author(s)
      Tsuruoka Kenjiro、Wakabayashi Shigeo、Morihara Hirofumi、Matsunaga Ninso、Fujisaka Yasuhito、Goto Isao、Imagawa Akihisa、Asahi Michio
    • Journal Title

      International Journal of Cardiology

      Volume: S0167-5273 Pages: 34641-34648

    • DOI

      10.1016/j.ijcard.2020.04.033

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08551, KAKENHI-PROJECT-19K16546, KAKENHI-PROJECT-19H01076
  • [Journal Article] Overexpression of Na+/H+ exchanger 1 specifically induces cell death in human iPS cells via sustained activation of the Rho kinase ROCK2019

    • Author(s)
      Shigeo Wakabayashi, Hirofumi Morihara, Shunichi Yokoe, Takatoshi Nakagawa, Kazumasa Moriwaki, Kiichiro Tomoda, Michio Asahi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 51 Pages: 19577-19588

    • DOI

      10.1074/jbc.ra119.010329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K16546
  • [Presentation] Effect of TMEM182, a novel membrane protein, on muscle differentiation2022

    • Author(s)
      森原 啓文, 古谷 壮一朗, 若林 繁夫, 朝日 通雄
    • Organizer
      第95回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K16546
  • [Presentation] Lysosomal Regulation of mTOR-AKT Signaling via the Vacuolar-type H+- ATPase2020

    • Author(s)
      森原 啓文, 友田 紀一郎, 朝日 通雄
    • Organizer
      第93回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-19K16546
  • [Presentation] ライソソームの正常機能を保証する V-ATPase の分子生物学的解析2019

    • Author(s)
      岡部 康教, 森原 啓文, 友田 紀一郎, 朝日 通雄
    • Organizer
      第136回 日本薬理学会近畿部会
    • Data Source
      KAKENHI-PROJECT-19K16546
  • [Presentation] Overexpression of the Na+/H+ exchanger NHE1 induces selective cell death of human iPS cells via sustained activation of rho kinase ROCK2019

    • Author(s)
      若林 繁夫, 友田 紀一郎, 横江 俊一, 森原 啓文, 朝日 通雄
    • Organizer
      第92回 日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-19K16546
  • 1.  藤阪 保仁 (50411369)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  朝日 通雄 (10397614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  大門 雅広 (20388268)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  神吉 佐智子 (40411350)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  若林 繁夫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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