Morihara Hirofumi 森原啓文

Researcher Number	40802674
Other IDs
Affiliation (Current)	2025: 大阪医科薬科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 大阪医科薬科大学, 医学部, 助教 2019 – 2020: 大阪医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 49010:Pathological biochemistry-related Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Basic Section 55030:Cardiovascular surgery-related
Keywords	Principal Investigator iPS細胞 / 液胞型プロトンATPase / 分子標的治療薬 / 薬剤起因性心臓障害 / mTOR / ハイスループットスクリーニング / ライソゾーム / ファブリー病 / ライソゾーム病 Except Principal Investigator 分子標的治療薬 … More / iPS細胞 / オシメルチニブ / がん治療関連心機能障害 / 大動脈解離 / 血管細胞モデル / 遺伝性結合組織疾患 / 人工多能性幹細胞 / Marfan症候群 / 薬剤起因性心臓障害 / がん / 心臓機能障害 Less

Mechanism of osimertinib-induced cardiac dysfunction
- Principal Investigator
  
  藤阪保仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
第3世代 EGFR チロシンキナーゼ阻害薬による心毒性と V-ATPase の関係性についてPrincipal Investigator
- Principal Investigator
  
  森原啓文
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Osaka Medical and Pharmaceutical University
がん分子標的治療薬起因性心臓機能障害モデル樹立とメカニズム解析
- Principal Investigator
  
  藤阪保仁
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Osaka Medical and Pharmaceutical University
The cell-based vascular model with the inducible pluripotent stem cells of Marfan syndrome.
- Principal Investigator
  
  大門雅広
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55030:Cardiovascular surgery-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Elucidation of the pathological role of vacuolar ATPase in lysosomal storage diseasesPrincipal Investigator
- Principal Investigator
  
  Morihara Hirofumi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Osaka Medical and Pharmaceutical University

All 2022 2020 2019

All Journal Article Presentation

[Journal Article] Intravenously Injected Pluripotent Stem Cell-derived Cells Form Fetomaternal Vasculature and Prevent Miscarriage in Mouse2020
- Author(s)
  Daimon Atsushi, Morihara Hirofumi, Tomoda Kiichiro, Morita Natsuko, Koishi Yoshinori, Kanki Kazuyoshi, Ohmichi Masahide, Asahi Michio
- Journal Title
  
  Cell Transplantation
  
  Volume: 29 Pages: 096368972097045-096368972097045
- DOI
  10.1177/0963689720970456
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16546
[Journal Article] Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is dependent on its time of administration in mice2020
- Author(s)
  Tsuruoka Kenjiro、Wakabayashi Shigeo、Morihara Hirofumi、Matsunaga Ninso、Fujisaka Yasuhito、Goto Isao、Imagawa Akihisa、Asahi Michio
- Journal Title
  
  International Journal of Cardiology
  
  Volume: S0167-5273 Pages: 34641-34648
- DOI
  10.1016/j.ijcard.2020.04.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08551, KAKENHI-PROJECT-19K16546, KAKENHI-PROJECT-19H01076
[Journal Article] Overexpression of Na+/H+ exchanger 1 specifically induces cell death in human iPS cells via sustained activation of the Rho kinase ROCK2019
- Author(s)
  Shigeo Wakabayashi, Hirofumi Morihara, Shunichi Yokoe, Takatoshi Nakagawa, Kazumasa Moriwaki, Kiichiro Tomoda, Michio Asahi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 51 Pages: 19577-19588
- DOI
  10.1074/jbc.ra119.010329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16546
[Presentation] Effect of TMEM182, a novel membrane protein, on muscle differentiation2022
- Author(s)
  森原啓文, 古谷壮一朗, 若林繁夫, 朝日通雄
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16546
[Presentation] Lysosomal Regulation of mTOR-AKT Signaling via the Vacuolar-type H+- ATPase2020
- Author(s)
  森原啓文, 友田紀一郎, 朝日通雄
- Organizer
  第93回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-19K16546
[Presentation] ライソソームの正常機能を保証する V-ATPase の分子生物学的解析2019
- Author(s)
  岡部康教, 森原啓文, 友田紀一郎, 朝日通雄
- Organizer
  第136回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-19K16546
[Presentation] Overexpression of the Na+/H+ exchanger NHE1 induces selective cell death of human iPS cells via sustained activation of rho kinase ROCK2019
- Author(s)
  若林繁夫, 友田紀一郎, 横江俊一, 森原啓文, 朝日通雄
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K16546

1. 藤阪保仁 (50411369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 朝日通雄 (10397614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大門雅広 (20388268)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 神吉佐智子 (40411350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 若林繁夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Morihara Hirofumi 森原 啓文

Research Projects

Research Products

Co-Researchers

Mechanism of osimertinib-induced cardiac dysfunction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

第3世代 EGFR チロシンキナーゼ阻害薬による心毒性と V-ATPase の関係性についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

がん分子標的治療薬起因性心臓機能障害モデル樹立とメカニズム解析

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The cell-based vascular model with the inducible pluripotent stem cells of Marfan syndrome.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathological role of vacuolar ATPase in lysosomal storage diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Intravenously Injected Pluripotent Stem Cell-derived Cells Form Fetomaternal Vasculature and Prevent Miscarriage in Mouse2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exacerbation of autoimmune myocarditis by an immune checkpoint inhibitor is dependent on its time of administration in mice2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Overexpression of Na+/H+ exchanger 1 specifically induces cell death in human iPS cells via sustained activation of the Rho kinase ROCK2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Effect of TMEM182, a novel membrane protein, on muscle differentiation2022

Author(s)

Organizer

Data Source

[Presentation] Lysosomal Regulation of mTOR-AKT Signaling via the Vacuolar-type H+- ATPase2020

Author(s)

Organizer

Data Source

[Presentation] ライソソームの正常機能を保証する V-ATPase の分子生物学的解析2019

Author(s)

Organizer

Data Source

[Presentation] Overexpression of the Na+/H+ exchanger NHE1 induces selective cell death of human iPS cells via sustained activation of rho kinase ROCK2019

Author(s)

Organizer

Data Source

Morihara Hirofumi 森原啓文