SHIMIZU Masato 清水正人

Researcher Number	50126231
Other IDs
External Links
Affiliation (based on the past Project Information) *help	1999 – 2000: Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Associate Professor, 生体材料工学研究所, 助教授 1990 – 1998: 東京医科歯科大学, 医用器材研究所, 助教授 1994: 東京医科歯科大学, 医用器材研, 助教授 1993: Tokyo Med. Dental Univ. Inst. Med. Dental Eng. Associate Professor, 医用研, 助教授
Review Section/Research Field	Principal Investigator Chemical pharmacy Except Principal Investigator 医薬分子機能学 / Chemical pharmacy
Keywords	Principal Investigator Vitamin D-receptor complex / Vitamin D receptor / Active vitamin D / ^<19>FNMR / ^<19>F-NMR / ビタミンD-受容体複合体 / ビタミンD受容体 / 活性型ビタミンD / フッ素化ビタミンDアナログ / Conformational analysis … More / ィイD119ィエD1FNMR / Fluorescent-labeled vitamin D analog / fluorovitamin D analog / ビタミンD-受容体コンプレックス / コンフォメーション / コンフォメーション解析 / ビタミンDー受容体複合体 / 蛍光性ビタミンDアナログ / Biological expression mechanism / Active conformation / Fluorovitamin D analog / 受容体結合活性 / 活性立体配座解析 / 4-フッ素化ビタミンD_3 / 19-フッ素化ビタミンD_3 / 活性型ビタミンD_3 / 作用発現機構 / 活性立体配座 / chemiluminescence / microcystin / retinoic asid / vitamin D metabolites / cycloaddition reaction / conjugated dienes / fluorometric assay / fluorescent dienophile / 付加反応 / 蛍光ラベル化 / 化学発光 / 環化付加反応 / 共役ジエン基 / 蛍光アッセイ法 / マイクロシスチン / レチノイン酸 / ビタミンD代謝物 / 蛍光性ジエノフィル … More Except Principal Investigator ビタミンD / アナログ / 生理活性 / ビタミンD結合蛋白 / 受容体 / 構造活性相関 / 配座解析 / 合成 / 1,25-ジヒドロキシビタミンD_3 / コンフォメーション解析 / Analogs / Vitamin D / receptor / vitamin D / 有機銅試薬 / 活性型ビタミンD / 化学合成 / Three-dimensional structure / Structure-function relationship / Differential action / Non-steroid vitamin D / Homology modeling / Nuclear receptor / 遺伝子転写 / 三次元構造 / 作用分離 / ノンステロイドビタミンD / ホモロジーモデリング / 核内受容体 / Recombinant DNA / Ligand-receptor complex / Vitamin D receptor / ^<19>F NMR / Fluorovitamin D / Conformational analysis / Analog synthesis / Active vitamin D / 配座制御 / 遺伝子組み替え / リガンド-受容体錯体 / ビタミンD受容体 / フッ素NMR / フッ素化ビタミンD / アナログ合成 / gene expression / receptor binding affinity / conformationally restricted analog / conformational restriction / conformation analysis / 1,25-dihydroxyvitamin D_3 / ビタミンDレセプター / 分子力場計算 / 分子設計 / ビタミンDアナログ / 立体選択的 / 面選択的共役付加反応 / 遺伝子発現 / 受容体結合活性 / 配座制御アナログ / 立体配座制御 / レセプター / 1,25-ジヒドロキシビタミンD3 / Photoisomerization / Vitamin D binding protein / Fluorination / Conformation analysis / Synthesis / Receptor / コンフォメーション / 光異性化反応 / フッソ化 / vitamin D binding protein / conjugate addition / structure activity relationship / conformational analysis / synthesis / analog / 側鎖修飾体 / 合成アナローグ / 共役付加反応 / アナローグ / Vitamin A / Retinoic acid / Triazolinediones / Chemical synthesis / Fluorometry / Fluorescent dienophile / Fluorescence-labeling / Vitamin D metabolites / ビタミンA / ビタミンA酸 / トリアゾリンジオン / 蛍光分析 / 蛍光性ジエノフィル / 蛍光標識 / ビタミンD代謝物 Less

Research Projects
(9 results)
Co-Researchers
(5 People)

De novo design and synthesis of aromatic vitamain D analogs having rigid three-dimensional structure and differential activity
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Three-dimensional structure of vitamin D ligand-receptor complex and its intracellular interactionPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Active Vitamin D Analogs with Restricted Conformation Mobility : Synthesis, Receptor Binding and Regulation of Gene Expression
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Confromational analysis of fluorovitamin D analogs interacting with vitamin D receptor using ^<19>F-NMR spectroscopyPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Conformational Analysis of Vitamin D Resposible for Binding to VDR and DBP
- Principal Investigator
  
  YAMAMOTO Keiko
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Studies on the conformation of active form of vitamin D responsible for binding to the receptor and for expression of the activities
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  Tokyo Medical and Dental University
Design and Synthesis of New Sensitive Dienophiles, and Application to the Quantitative Analysis of Biologically Active Conjugated DienesPrincipal Investigator
- Principal Investigator
  
  SHIMIZU Masato
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Studies on the synthesis, conformational analysis, and biological activity of active vitamin D analogs in the purpose of developing therapeutic agent with selective activity
- Principal Investigator
  
  YMADA Sachiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University
Syntheses and Application of the Functional Compounds Designed to Study the Metabolism and the Mechanism of the Action of Vitamin D
- Principal Investigator
  
  YAMADA Sachiko
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Tokyo Medical and Dental University

1. YAMADA Sachiko (10014078)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. YAMAMOTO Keiko (90147017)

# of Collaborated Projects: 8 results

# of Collaborated Products: 0 results
3. DELUCA Hecto

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. DELUCA H.F.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. REISCHL Wolfgang

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SHIMIZU Masato 清水 正人

Research Projects

Co-Researchers

De novo design and synthesis of aromatic vitamain D analogs having rigid three-dimensional structure and differential activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Three-dimensional structure of vitamin D ligand-receptor complex and its intracellular interactionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Active Vitamin D Analogs with Restricted Conformation Mobility : Synthesis, Receptor Binding and Regulation of Gene Expression

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Confromational analysis of fluorovitamin D analogs interacting with vitamin D receptor using ^<19>F-NMR spectroscopyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Conformational Analysis of Vitamin D Resposible for Binding to VDR and DBP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the conformation of active form of vitamin D responsible for binding to the receptor and for expression of the activities

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and Synthesis of New Sensitive Dienophiles, and Application to the Quantitative Analysis of Biologically Active Conjugated DienesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the synthesis, conformational analysis, and biological activity of active vitamin D analogs in the purpose of developing therapeutic agent with selective activity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Syntheses and Application of the Functional Compounds Designed to Study the Metabolism and the Mechanism of the Action of Vitamin D

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

SHIMIZU Masato 清水正人