TAKEHARA KAZUHIKO 竹原和彦

… Alternative Names

TAKEHARA Kazuhiko 竹原和彦

竹原和彦タケハラカズヒコ

Less

Researcher Number	50142253
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011 – 2019: 金沢大学, 医学系, 教授 2005 – 2007: Kanazawa University, School of Medicine, Professor, 医学系研究科, 教授 2002 – 2004: Kanazawa University Graduate School of Medical Science, Professor., 大学院・医学系研究科, 教授 2003: Kanazawa University, School of Medicine, Professor, 大学院医学系研究科, 教授 2001: 金沢大学, 医学系研究科, 教授 … More 2000: Kanazawa University School of Medicine, Professor, 医学部・皮膚科, 教授 1997 – 2000: 金沢大学, 医学部, 教授 1995: 金沢大学, 医学部, 教授 Less
Review Section/Research Field	Principal Investigator Dermatology / Dermatology Except Principal Investigator Dermatology / Dermatology
Keywords	Principal Investigator TGF-β / CTGF / 線維化 / fibrosis / B細胞 / 全身性強皮症 / コラーゲン / collagen / IL-10 / 制御性B細胞 … More / 強皮症 / 繊維化 / systemic sclerosis / c-myc / ICAM-1 / LFA-1 / フィブロネクチン / 自己抗体 / アポトーシス / 膠原病 / Syk / CTGE / トランス二ェニックマウス / TGFβ / 動物モデル / transgenic mouse / b-FGF / 中和抗体 / 線維芽細胞 / モノクロナール抗体 / 皮膚生理学 / monoclonal antibody / IL-6 / エフェクターB細胞 / サイトカイン … More Except Principal Investigator CD19 / CD22 / ICAM-1 / B細胞 / 自己免疫 / L-selectin / p16 / tight skin mouse 1 / autoimmunity / CD21 / CD23 / CCR4 / CXCR3 / 免疫複合体 / 細胞接着分子 / 血管炎 / アルサス反応 / Immune complex / Cell adhesion molecule / vasculitis / Arthus reaction / シグナル伝達分子 / Vav / 悪性黒色腫 / P16 / 転移 / LOH / 癌抑制遺伝子 / 6番染色体 / マイクロサテライト / 転移抑制遺伝子 / 第9染色体 / melanoma / tumor suppressor gene / metastasis / loss of heterozygosity / chromosome / microsatellites / 紫外線 / 形質転換成長因子・β / サイクリン / 細胞増殖 / 表皮 / 形質転換成長因子-β / 形質転換増殖因子β / Ultraviolet rays / Transforming growth factor-beta / Cyclin / Cell proliferation / Epidermis / 全身性強皮症 / 動物モデル / tight skin mouse I / systemic sclerosis / B lymphocytes / animal model / 水疱性類天疱瘡 / 天疱瘡 / 自己免疫性水疱症 / 水疱症類天疱瘡 / 尋常性天疱瘡 / 落葉状天疱瘡 / Bリンパ球 / bullous pemphigoid / pemphigus / B cell / 尋常性乾癬 / リンパ球 / インターフェロン-γ / インターロイキン-4 / 乾癬 / T細胞 / インターロイキン4 / Psoriasis vulgaris / Lymphocytes / Interferon-γ / Interleukin-4 / L-Selectin / E-セレクチン / P-セレクチン / L-セレクチン / ノックアウトマウス / 肥満細胞 / 好中球 / P-selectin / E-selectin Less

The role of Effector B cell in Systemic SclerosisPrincipal Investigator
- Principal Investigator
  
  Takehara Kazuhiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The role of Syk in the pathogenesis of systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  Takehara Kazuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis modelsPrincipal Investigator
- Principal Investigator
  
  TAKEHARA KAZUHIKO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The inhibition by anti-CTGF antibody produced by the DNA immunization method in the cytokine induced skin fibrosis model micePrincipal Investigator
- Principal Investigator
  
  TAKEHARA Kazuhiko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The investigation of the mechanisms of upregulated collagen production of cytokine-induced skin fibrosis model.Principal Investigator
- Principal Investigator
  
  TAKEHARA Kazuhiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  KANAZAWA UNIVERSITY
Relative contribution of various adhesion molecules to tissue injury induced by immune complex deposition
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Study of the mechanism of skin fibrosis by utilizing transgenic mice : A mouse scieroderma modelPrincipal Investigator
- Principal Investigator
  
  TAKEHARA Kazuhiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  KANAZAWA UNIVERSITY
Involvement of chemokine receptor expression and cytokine production by T lymphocytes in the pathogenesis of psoriasis.
- Principal Investigator
  
  INAOKI Makoto
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa university
In vivo role of adhesion molecules in inflammation induced by immur complex deposition
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
膠原病におけるアポトーシス誘導・表皮細胞及び血管内被細胞に対する自己抗体Principal Investigator
- Principal Investigator
  
  竹原和彦
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
CD19,CD22による自己抗体産生機序に関与するシグナル伝達分子の同定
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kanazawa University
Expression levels of CD19 and CD22 in autoimmune bullous disease and their effect on antibody production.
- Principal Investigator
  
  INAOKI Makoto
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Development of the new animal model for systemic sclerosis using the immunologic function of CD19 and CD22
- Principal Investigator
  
  SATO Shinichi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Role of connective tissue growth factor (CTGF) in association with systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  TAKEHARA Kazuhiko
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  KANAZAWA UNIVERSITY
Molecular genetic investigation of Japanese cutaneous melanoma
- Principal Investigator
  
  TAKATA Minoru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  KANAZAWA UNIVERSITY
The roles of transforming growth factor-beta on chronic cutaneous injuries due to ultraviolet exposures
- Principal Investigator
  
  KAWARA Shigeru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
トランスフォーミング成長因子βによる皮膚線維化の機構についてPrincipal Investigator
- Principal Investigator
  
  竹原和彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University

All 2017 2016 2015 2014 2013 2012 2011 2008 2007 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] Systemi Sclerosis.2016
- Author(s)
  Takehara K, Fujimoto M, Kuwana M
- Total Pages
  247
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-26461680
[Book] 皮膚科臨床アセット、アトピー性皮膚炎の疫学2011
- Author(s)
  竹原和彦
- Total Pages
  4
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591640
[Book] 皮膚疾患の最新治療2011
- Author(s)
  竹原和彦
- Total Pages
  1
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591640
[Book] アトピー性皮膚炎診療が楽しくなる！Q＆Aで考える実践治療2011
- Author(s)
  竹原和彦
- Total Pages
  212
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591640
[Book] 皮膚科臨床アセット、アトピー性皮膚炎の診断基準，鑑別診断2011
- Author(s)
  伊川友香，竹原和彦
- Total Pages
  5
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23591640
[Book] 皮膚科膠原病診療のすべて2011
- Author(s)
  竹原和彦
- Total Pages
  3
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591640
[Book] アトピー性皮膚炎診療が楽しくなる!Q&Aで考える実践治療2011
- Author(s)
  竹原和彦
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Blockade of p38 Mitogen-Activated Protein Kinase Inhibits Murine Sclerodermatous Chronic Graft-versus-Host Disease2017
- Author(s)
  Matsushita T, Date M, Kano M, Mizumaki K, Tennichi M, Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 187 Pages: 841-850
- DOI
  10.1016/j.ajpath.2016.12.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04885, KAKENHI-PROJECT-26461680
[Journal Article] Decreased levels of regulatory B cells in patients with systemic sclerosis: association with autoantibody production and disease activity.2016
- Author(s)
  Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
- Journal Title
  
  Rheumatology
  
  Volume: 55 Pages: 263-267
- DOI
  10.1093/rheumatology/kev331
- NAID
  120005764209
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461680, KAKENHI-PROJECT-25461686, KAKENHI-PROJECT-15H04885
[Journal Article] Clinical and immunological predictors of scleroderma renal crisis for Japanese systemic sclerosis patients with anti-RNA polymerase III autoantibodies..2015
- Author(s)
  Hamaguchi Y, Kodera M, Matsushita T, Usuda T, Kuwana M, Takehara K, and Fujimoto M
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 67 Pages: 1045-1052
- DOI
  10.1002/art.38994
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461471, KAKENHI-PROJECT-26461680, KAKENHI-PROJECT-25461686
[Journal Article] The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients2014
- Author(s)
  Hatta Y, Hasegawa M, Matsushita T, Hamaguchi Y, Fujimoto M, Takehara K.
- Journal Title
  
  Mod Rheumatol
  
  Volume: 24 Pages: 377-9
- DOI
  10.3109/14397595.2013.854073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] A crucial role of L-selectin in C protein-induced experimental polymyositis of mice2014
- Author(s)
  Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J, Weinhart M, Haag R, Tedder TF, Takehara K, Kohsaka H, Fujimoto M.
- Journal Title
  
  Arthritis Rheumatol
  
  Volume: mar 18 Pages: 1864-71
- DOI
  10.1002/art.38630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-25461686
[Journal Article] Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis : a multicentre, prospective, observational study2014
- Author(s)
  Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K.
- Journal Title
  
  PLoS One
  
  Volume: 9
- DOI
  10.1371/journal.pone.0088150
- NAID
  120006986537
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Autoantibodies to RuvBL1 and RuvBL2: a novel systemic sclerosis-related antibody associated with diffuse cutaneous and skeletal muscle involvement2014
- Author(s)
  Kaji K, Fertig N, Medsger TA Jr, Satoh T, Hoshino K, Hamaguchi Y, Hasegawa M, Lucas M, Schnure A, Ogawa F, Sato S, Takehara K, Fujimoto M, Kuwana M.
- Journal Title
  
  Arthritis Care Res (Hoboken)
  
  Volume: 66 Pages: 575-584
- DOI
  10.1002/acr.22163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-26461471
[Journal Article] 6.A crucial role of L-selectin in C protein-induced experimental polymyositis in mice.2014
- Author(s)
  Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J, Weinhart M, Haag R, Tedder TF, Takehara K, Kohsaka H, Fujimoto M.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 66 Pages: 1864-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461680
[Journal Article] 7.The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients.2014
- Author(s)
  Hatta Y, Hasegawa M, Matsushita T, Hamaguchi Y, Fujimoto M, Takehara K.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 24 Pages: 377-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461680
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Tedder TF, Fujimoto M.
- Journal Title
  
  Blood
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, T akehara K, T edder TF, Fujimoto M
- Journal Title
  
  Blood.
  
  Volume: 121 Pages: 3274-83
- DOI
  10.1182/blood-2012-11-465658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260, KAKENHI-PROJECT-24659523
[Journal Article] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis : comparison with a UK Caucasian cohort2013
- Author(s)
  Fujimoto M
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 72 Pages: 151-153
- DOI
  10.1136/annrheumdis-2012-201736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591245, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260, KAKENHI-PROJECT-25461672
[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013
- Author(s)
  Fujimoto M, Matsushita T, Hamaguchi Y, Kaji K, Asano Y, Ogawa F, Yamaoka T, Fujikawa K, Tsukada T, Sato K, Echigo T, Hasegawa M, Takehara K.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: 72 Pages: 151-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M
- Journal Title
  
  Arthritis Rheum.
  
  Volume: in press Pages: 1624-35
- DOI
  10.1002/art.37933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24659523, KAKENHI-PROJECT-25461686
[Journal Article] High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies2013
- Author(s)
  Hamaguchi Y, Matsushita T, Hasegawa M, Ueda-Hayakawa I, Sato S, Takehara K, Fujimoto M
- Journal Title
  
  Mod Rheumatol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.2013
- Author(s)
  Hasegawa M, Higashi K, Matsushita T, Hamaguchi Y, Saito K, Fujimoto M, Takehara K.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 70 Pages: 34-41
- DOI
  10.1016/j.jdermsci.2013.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] BLNK expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.2013
- Author(s)
  Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Huu DL, Ishiura N, Naka K, Hirao A, Takehara K, Fujimoto M
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: 131 Pages: 1674-1682
- DOI
  10.1016/j.jaci.2013.01.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260
[Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis.2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, Takehara K.
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 64 Pages: 3726-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Potential roles of interleukin-17A in the development of skin fibrosis in mice2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, T akehara K
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 64 Pages: 3726-35
- DOI
  10.1002/art.34643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24220011
[Journal Article] Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.2012
- Author(s)
  Hasebe N, Kawasaki A, Ito I, Kawamoto M, Hasegawa M, Fujimoto M, Furukawa H, Tohma S, Sumida T, Takehara K, Sato S, Kawaguchi Y, Tsuchiya N.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: 71 Pages: 1259-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Host-derived MCP-1 and MIP-1αregulate protective anti-tumor immunity to localized and metastatic B16 melanoma2012
- Author(s)
  Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
- Journal Title
  
  Am J Pathol
  
  Volume: 180(1) Pages: 365-74
- DOI
  10.1016/j.ajpath.2011.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis : a multicentre prospective observational study2012
- Author(s)
  Hasegawa M, Asano Y, Endo H, Fujimoto M, Goto D, Ihn H, Inoue K, Ishikawa O, Kawaguchi Y, Kuwana M, Muro Y, Ogawa F, Sasaki T, Takahashi H, Tanaka S, Takehara K, Sato S.
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 51 Pages: 129-133
- DOI
  10.1093/rheumatology/ker333
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591618, KAKENHI-PROJECT-23591640
[Journal Article] Myositis-specific anti-155/140 autoantibodies target transcriptional intermediary factor 1 family proteins2012
- Author(s)
  Fujimoto M, Hamaguchi Y, Kaji K, Matsushita T, Ichimura Y, Kodera M, Ishiguro N, Ueda-Hayakawa I, Asano Y, Ogawa F, Fujikawa K, Miyagi T, Mabuchi E, Hirose K, Akimoto N, Hatta N, Tsutsui K, Higashi A, Igarashi A, Seishima M, Hasegawa M, Takehara K
- Journal Title
  
  Arthritis Rheum
  
  Volume: 64(2) Pages: 513-22
- DOI
  10.1002/art.33403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24590185
[Journal Article] Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy2012
- Author(s)
  Ichimura Y, Matsushita T, Hamaguchi Y, Kaji K, Hasegawa M, Tanino Y, Inokoshi Y, Kawai K, Kanekura T, Habuchi M, Igarashi A, Sogame R, Hashimoto T, Koga T, Nishino A, Ishiguro N, Sugimoto N, Aoki R, Ando N, Abe T, Kanda T, Kuwana M, Takehara K, Fujimoto M
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71(5) Pages: 710-3
- DOI
  10.1136/annrheumdis-2011-200697
- NAID
  120004442395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260
[Journal Article] Use of serum clara cell 16-kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis2011
- Author(s)
  Hasegawa M, Fujimoto M, Hamaguchi Y, Matsushita T, Inoue K, Sato S, Takehara K
- Journal Title
  
  J Rheumatol
  
  Volume: 38(5) Pages: 877-84
- DOI
  10.3899/jrheum.100591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Association between nail-fold capillary findings and disease activity in dermatomyositis2011
- Author(s)
  Mugii N, Hasegawa M, Matsushita T, Hamaguchi Y, Horie S, Yahata T, Inoue K, Someya F, Fujimoto M, Takehara K
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 50(6) Pages: 1091-8
- DOI
  10.1093/rheumatology/keq430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis : a multicenter cross-sectional study2011
- Author(s)
  Hamaguchi Y, Kuwana M, Hoshino K, Hasegawa M, Kaji K, Matsushita T, Komura K, Nakamura M, Kodera M, Suga N, Higashi A, Ogusu K, Muro Y, et al. （全37名中17番目）
- Journal Title
  
  Arch Dermatol
  
  Volume: 147 Pages: 391-398
- DOI
  10.1001/archdermatol.2011.52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591618, KAKENHI-PROJECT-23591640
[Journal Article] Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production2011
- Author(s)
  Maeda S, Fujimoto M, Matsushita T, Hamaguchi Y, Takehara K, Hasegawa M
- Journal Title
  
  Am J Pathol
  
  Volume: 179(5) Pages: 2360-9
- DOI
  10.1016/j.ajpath.2011.07.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Neutralizing monoclonal antibody to human connective tissue growth facfor ameliorates transforming growth factor-β-induced mouse fibrosis2008
- Author(s)
  Ikawa Y, POH-SING NG, Endo K, Kondo M, Chujo S, Ishida W, Shirasaki F, Fujimoto M, Takehara K
- Journal Title
  
  J Cellular Physiol掲載(発行)確定 14(in press)
  
  Pages: 680-687
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591240
[Journal Article] Connective Tissue Growth Factor Causes Persistent Proa2(I) Collagen Gene Expression Induced by Transforming Growth Factor-β in a Mouse Fibrosis Model2005
- Author(s)
  Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, Inaoki M, Takigawa M, Takehara K
- Journal Title
  
  Journal Cellular Physiology 203・2
  
  Pages: 447-456
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591093
[Journal Article] Connective Tissue Growth Factor Causes Persistent Proa2(I) Collagen Gene Expression I nduced by Transforming Growth Factor-βin a Mouse Fibrosis Model2005
- Author(s)
  Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, Inaoki M, Takigawa M, Takehara K
- Journal Title
  
  Journal Cellular Physiology 203(2)
  
  Pages: 447-456
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591093
[Journal Article] P-selectin glycoprotein-1 is required for the development of cutaneous vasculitis induced by immune complex deposition.2004
- Author(s)
  Yanaba K, Komura K, Hamaguchi Y, Horikawa M, Matsushita Y, Takehara K, Sato S
- Journal Title
  
  J Leukoc Biol 76
  
  Pages: 374-382
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591171
[Journal Article] P-selectin glycoprotein-I is required for the development of cutaneous vasculitis induced by immune complex deposition2004
- Author(s)
  Yanaba K, Komura K, Hamaguchi Y, Horikawa M, Matsushita Y, Takehara K, Sato S
- Journal Title
  
  Journal of Leukocyte Biology 76(2)
  
  Pages: 374-382
- Data Source
  KAKENHI-PROJECT-15591171
[Journal Article] P-selectin glycoprotein-I is required for the development of cutaneous vasculitis induced by immune complex deposition2004
- Author(s)
  Yanaba K, Komura K, Hamaguchi Y, Horikawa M, Matsushita Y, Takehara K, Sato S
- Journal Title
  
  Journal of Leukocyte Biology 76
  
  Pages: 374-382
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591171
[Journal Article] Connective tissue growth factor causes persistent proalpha 2(I) Collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model.2004
- Author(s)
  Chujo S, Shirasaki F, Kawara S, Inagaki Y, Kinbara T, Inaoki M, Takigawa M, Takehara K
- Journal Title
  
  Journal Cellular Physiology (in press)
- Data Source
  KAKENHI-PROJECT-16591093
[Journal Article] Relative Contributions of Selectins and Intercellular Adhesion Molecule-1 to Tissue Injury Induced by Immune Complex Deposition.2003
- Author(s)
  Yanaba K, Kaburagi Y, Takehara K, Steeber DA, Tedder TF, Sato S
- Journal Title
  
  Am J Pathol 162
  
  Pages: 1463-1473
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15591171
[Journal Article] Relative Contributions of Selectins and Intercellular Adhesion Molecule-1 to Tissue Injury Induced by Immune Complex Deposition2003
- Author(s)
  Yanaba K, Kaburagi Y, Takehara K, Steeber DA, Tedder TF, Sato S
- Journal Title
  
  American Journal of Pathology 162
  
  Pages: 1462-1473
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15591171
[Journal Article] Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor B-induced mouse fibrosis
- Author(s)
  Ikawa, Y., POH-SING, NG, Endo, K., Kondo, M., Chujo, S., WATARU, Shirasaki, F., Fujimoto, M., Takehara, K
- Journal Title
  
  Journal of Cellular Physiology (in print)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Journal Article] Neutralizing monoclonal antibody to human connective tissue growth facfor ameliorates transforming growth factor-β-induced mouse fibrosis
- Author(s)
  Ikawa Y, POH-SING NG, Endo K, Kondo M, Chujo S, Ishida W, Shirasaki F, Fujimoto M, Takehara K
- Journal Title
  
  Journal of Cellular Physiology (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] Current topics in systemic sclerosis2016
- Author(s)
  Takehara K
- Organizer
  Vietnamese Society of Dermatology & Venerelogy
- Place of Presentation
  Vietnam
- Year and Date
  2016-03-25
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] 抗トポイソメラーゼⅠ抗体陽性の小児限局性強皮症の１例2015
- Author(s)
  竹原和彦，清水恭子，松下貴史，濱口儒人
- Organizer
  日本皮膚科学会新潟地方会
- Place of Presentation
  新潟
- Year and Date
  2015-04-05
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association witn autoantibody production2015
- Author(s)
  Matsushita T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K
- Organizer
  45th Annual ESDR Meeting
- Place of Presentation
  オランダ
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] T Cyclosporine-Therapy in localozed scleroderma2014
- Author(s)
  Takehara K
- Organizer
  3rd World Congress on Systemic Sclerosis
- Place of Presentation
  Roma Italy : Ergife Palace Hotel & Conference Center
- Year and Date
  2014-02-06
- Invited
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] アトピー性皮膚炎診療が楽しくなる～小児における実践治療を中心に～2012
- Author(s)
  竹原和彦
- Organizer
  第25回近畿小児科学会(招待講演)
- Place of Presentation
  京都、キャンパスプラザ
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] アトピー性皮膚炎診療が楽しくなる～小児における実践治療を中心に～2012
- Author(s)
  竹原和彦
- Organizer
  第25回近畿小児科学会
- Place of Presentation
  キャンパスプラザ京都
- Year and Date
  2012-03-11
- Invited
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] 特別発言～膠原病を診る若手医師の育成を目指して～2012
- Author(s)
  竹原和彦
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  京都市、国立京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] 豚原病を診る若手医師の育成を目指して2012
- Author(s)
  竹原和彦
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  京都国際会館(特別発言)
- Invited
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] アトピービジネス問題再考2012
- Author(s)
  竹原和彦
- Organizer
  第111回日本皮膚科学会総会
- Place of Presentation
  京都市、国立京都国際会館
- Invited
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] びまん型全身性強皮症に対するIVIGの二重盲検比較試験2011
- Author(s)
  竹原和彦
- Organizer
  第39回日本臨床免疫学会総会
- Place of Presentation
  東京、京王プラザホテル
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] びまん型全身性強皮症に対するIVIGの三重盲検比較試験2011
- Author(s)
  竹原和彦
- Organizer
  第39回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] TGF-βで誘導されるモデルマウスの線維化が抗CTGF抗体で抑制された2007
- Author(s)
  伊川友香, 松下幸世, 近藤美幾藤本晃英, 長川稔, 竹原和彦, 刀祢裕美, 和田泰三, 谷内江昭宏
- Organizer
  第1回日本CCNファミリ-研究会
- Place of Presentation
  岡山市
- Year and Date
  2007-10-27
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] Neutralizing antibody to human connective tissue growth factor ameliorates transforming growth factor-β induced mouse fibrosis model2007
- Author(s)
  Ikawa Y, Kondo M, Chujo S, Shirasaki F, Fujimoto M, Ng Poh-Sing, Takehara K
- Organizer
  Professor E. Carwaile LeRoy Memorial International Workshop on Scleroderma
- Place of Presentation
  Tokyo
- Year and Date
  2007-05-20
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] Neutralizing antibody to human connective tissue growth factor ameliorates transforming growth factor induced mouse fibrosis model2007
- Author(s)
  Ikawa, Y., Ng, Poh-Sing, Miyazaki, M., Chujo, S., Ishida, W., Shirasaki, F., Fujimoto, M., Takehara, K
- Organizer
  Japan CCN family Society
- Place of Presentation
  Okayama
- Year and Date
  2007-10-07
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] TGF一βで誘導されるモデルマウスの線維化が抗CTGF抗体で抑制された2007
- Author(s)
  伊川友香, 松下幸世, 近藤美幾, 藤本晃英, 長谷川稔, 竹原和彦, 刀祢裕美, 和田泰三, 谷内江昭宏
- Organizer
  第1回日本CCNファミリー研究会
- Place of Presentation
  岡山市
- Year and Date
  2007-10-28
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] Neutralizing antibody to human connective tissue growth factor ameliorates transforming growth factor-β induced mouse fibrosis model2007
- Author(s)
  Ikawa Y, Kondo M, Chujo S, Shirasaki F, Fujimoto M, NgPoh-Sing, Takehara K
- Organizer
  Professor E.Carwaile LeRoy Memorial International Workshop on Scleroderma
- Place of Presentation
  Tokyo
- Year and Date
  2007-05-20
- Data Source
  KAKENHI-PROJECT-18591240
[Presentation] T Cyclosporine-Therapy in localozed scleroderma
- Author(s)
  Takehara K
- Organizer
  3rd World Congress on Systemic Sclerosis
- Place of Presentation
  Roma Italy
- Invited
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] Blockade of Syk Ameliorates the Development of Sclerodermatous Chronic Graft-Versus-Host Disease.
- Author(s)
  Matsushita T, Le Huu D, Kimura H, Date M, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K
- Organizer
  ESDR 2014
- Place of Presentation
  Copenhagen
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] アトピー性皮膚炎治療におけるガイドラインの役割（ワークショップ）
- Author(s)
  竹原和彦
- Organizer
  アトピー性皮膚炎治療研究会第19回シンポジム
- Place of Presentation
  広島　広島大学医学部広仁会館
- Invited
- Data Source
  KAKENHI-PROJECT-23591640
[Presentation] 内科医が知っておくべき皮膚疾患／ｱﾄﾋﾟｰ性皮膚炎（教育講演）
- Author(s)
  竹原和彦
- Organizer
  第27回日本臨床内科医学会
- Place of Presentation
  神戸　神戸国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-23591640

1. SATO Shinichi (20215792)

# of Collaborated Projects: 10 results

# of Collaborated Products: 5 results
2. HASEGAWA Minoru (50283130)

# of Collaborated Projects: 3 results

# of Collaborated Products: 24 results
3. MATSUSHITA Takashi (60432126)

# of Collaborated Projects: 3 results

# of Collaborated Products: 30 results
4. KAWARA Shigeru (80186155)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. INAOKI Makoto (40242549)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIRASAKI Fumiaki (10313644)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. FUJIMOTO Manabu (90272591)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
8. TAKATA Minoru (20154784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HATTA Naohito (30272959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. CHUJO Sonoko (20401911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. OGAWA Fumihide

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. OGAWA Yasushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 室慶直

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 桑名正隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKEHARA KAZUHIKO 竹原 和彦

TAKEHARA Kazuhiko 竹原 和彦

竹原 和彦 タケハラ カズヒコ

Research Projects

Research Products

Co-Researchers

The role of Effector B cell in Systemic SclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Syk in the pathogenesis of systemic sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis modelsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The inhibition by anti-CTGF antibody produced by the DNA immunization method in the cytokine induced skin fibrosis model micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The investigation of the mechanisms of upregulated collagen production of cytokine-induced skin fibrosis model.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the mechanism of skin fibrosis by utilizing transgenic mice : A mouse scieroderma modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

膠原病におけるアポトーシス誘導・表皮細胞及び血管内被細胞に対する自己抗体Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of connective tissue growth factor (CTGF) in association with systemic sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

TAKEHARA KAZUHIKO 竹原和彦

TAKEHARA Kazuhiko 竹原和彦

竹原和彦タケハラカズヒコ