Matsushita Takashi 松下貴史

… Alternative Names

MATSUSHITA Takashi 松下貴史

松下貴史マツシタタカシ

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Researcher Number	60432126
Other IDs
External Links
Affiliation (Current)	2025: 金沢大学, 医学系, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 金沢大学, 医学系, 教授 2016 – 2019: 金沢大学, 附属病院, 講師 2017: 金沢大学, 医学部附属病院, 助手 2013 – 2015: 金沢大学, 大学病院, 講師 2012: 金沢大学, 医学系, 医学系 … More 2010 – 2012: Kanazawa University, 医学系, 助教 2007: 金沢大, 医学部附属病院, 助手 2006: 金沢大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related Except Principal Investigator Dermatology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 49010:Pathological biochemistry-related / Tumor therapeutics
Keywords	Principal Investigator 全身性強皮症 / 制御性B細胞 / B細胞 / IL-10 / サイトカイン / 強皮症 / IL-6 / Effector B細胞 / Regulatory B細胞 / BAFF … More / GM-CSF / Ｂ細胞 / レパトア解析 / Effectro B細胞 / エフェクターB細胞 / 治療 / 自己免疫疾患 / 制御性B細胞 IL-10 / GVHD / 自己抗体 / 線維化 … More Except Principal Investigator 制御性B細胞 / 全身性強皮症 / B細胞 / IL-10 / 癌転移 / 幹細胞 / 免疫寛容 / laeverin / 胚シグナル / 炎症 / オキシトシン / サイトカイン / エフェクターB細胞 / IL-6 / Regulatoly B細胞 / 腫瘍免疫 / 免疫療法 / 悪性黒色腫 / 線維化 / Syk Less

Development of selective GM-CSF-producing effector B cell inhibition therapy in systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  松下貴史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kanazawa University
全身性強皮症におけるＢ細胞の包括的解析Principal Investigator
- Principal Investigator
  
  松下貴史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kanazawa University
Elucidation of anti-inflammatory functions by oxytocin
- Principal Investigator
  
  Yamamoto Yasuhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Kanazawa University
新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用
- Principal Investigator
  
  藤原浩
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Kanazawa University
Development of a Novel Treatment for Scleroderma by Regulation of Cytokine-Producing B CellsPrincipal Investigator
- Principal Investigator
  
  Matsushita Takashi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kanazawa University
The role of Effector B cell in Systemic Sclerosis
- Principal Investigator
  
  Takehara Kazuhiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
A role of regulatory B cell in tumor immunity
- Principal Investigator
  
  Kobayashi Tadahiro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kanazawa University
The role of cytokine producing B cell in scleroderma mouse modelPrincipal Investigator
- Principal Investigator
  
  Matsushita Takashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The role of Syk in the pathogenesis of systemic sclerosis
- Principal Investigator
  
  Takehara Kazuhiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The role of regulatory B cell in the pathogenesis of systemic sclerosisPrincipal Investigator
- Principal Investigator
  
  Matsushita Takashi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models
- Principal Investigator
  
  TAKEHARA KAZUHIKO
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Analysis of PI3K signaling role in regulatory B cellsPrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
Research of regulatory B cell role in sclerodermatous GVHD mousePrincipal Investigator
- Principal Investigator
  
  MATSUSHITA Takashi
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University
BAFFアンタゴニストによる強皮症モデルマウスの治療Principal Investigator
- Principal Investigator
  
  松下貴史
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Kanazawa University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Regulatory and effector B cells: Friends or foes?2019
- Author(s)
  Matsushita Takashi
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 93 Issue: 1 Pages: 2-7
- DOI
  10.1016/j.jdermsci.2018.11.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10147
[Journal Article] BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance2018
- Author(s)
  Matsushita Takashi、Kobayashi Tadahiro、Mizumaki Kie、Kano Miyu、Sawada Tomoyo、Tennichi Momoko、Okamura Ai、Hamaguchi Yasuhito、Iwakura Yoichiro、Hasegawa Minoru、Fujimoto Manabu、Takehara Kazuhiko
- Journal Title
  
  Science Advances
  
  Volume: 4 Issue: 7 Pages: 9944-9944
- DOI
  10.1126/sciadv.aas9944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05045, KAKENHI-PROJECT-18H02671, KAKENHI-PROJECT-16K10147
[Journal Article] Blockade of p38 Mitogen-Activated Protein Kinase Inhibits Murine Sclerodermatous Chronic Graft-versus-Host Disease.2017
- Author(s)
  Matsushita T, Date M, Kano M, Mizumaki K, Tennichi M, Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K.
- Journal Title
  
  Am J Pathol
  
  Volume: 187 Issue: 4 Pages: 841-850
- DOI
  10.1016/j.ajpath.2016.12.016
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H04885, KAKENHI-PROJECT-26461680
[Journal Article] Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association with autoantibody production and disease activity.2016
- Author(s)
  Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
- Journal Title
  
  Rheumatology (Oxford).
  
  Volume: 55 Issue: 2 Pages: 263-267
- DOI
  10.1093/rheumatology/kev331
- NAID
  120005764209
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461680, KAKENHI-PROJECT-25461686, KAKENHI-PROJECT-15H04885
[Journal Article] Clinical and immunological predictors of scleroderma renal crisis in Japanese systemic sclerosis patients with anti-RNA polymerase III antibodies.2015
- Author(s)
  Hamaguchi Y, Kodera M, Matsushita T, Usuda T, Kuwana M, Takehara K, and Fujimoto M
- Journal Title
  
  Arthritis Rheumatol
  
  Volume: 67 Issue: 4 Pages: 1045-1052
- DOI
  10.1002/art.38994
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26461471, KAKENHI-PROJECT-26461680, KAKENHI-PROJECT-25461686
[Journal Article] The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients.2014
- Author(s)
  Hatta Y, Hasegawa M, Matsushita T, Hamaguchi Y, Fujimoto M, Takehara K.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 24 Issue: 2 Pages: 377-9
- DOI
  10.3109/14397595.2013.854073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] A crucial role of L-selectin in C protein-induced experimental polymyositis of mice.2014
- Author(s)
  Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J, Weinhart M, Haag R, Tedder TF, Takehara K, Kohsaka H, Fujimoto M.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: mar 18 Issue: 7 Pages: 1864-71
- DOI
  10.1002/art.38630
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-25461686
[Journal Article] B cells promote tumor immunity against B16F10 melanoma.2014
- Author(s)
  Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K, Matsushita T.
- Journal Title
  
  Am J Pathol.
  
  Volume: 184 Issue: 11 Pages: 3120-3129
- DOI
  10.1016/j.ajpath.2014.07.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461686, KAKENHI-PROJECT-26670521
[Journal Article] Regulatory B cells in mouse models of systemic lupus erythematosus (SLE).2014
- Author(s)
  Matsushita T.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1190 Pages: 195-205
- DOI
  10.1007/978-1-4939-1161-5_14
- ISBN
  9781493911608, 9781493911615
- Data Source
  KAKENHI-PROJECT-25461686
[Journal Article] 6.A crucial role of L-selectin in C protein-induced experimental polymyositis in mice.2014
- Author(s)
  Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J, Weinhart M, Haag R, Tedder TF, Takehara K, Kohsaka H, Fujimoto M.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 66 Pages: 1864-71
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461680
[Journal Article] 7.The clinical characteristics of juvenile-onset systemic sclerosis in Japanese patients.2014
- Author(s)
  Hatta Y, Hasegawa M, Matsushita T, Hamaguchi Y, Fujimoto M, Takehara K.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: 24 Pages: 377-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461680
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Tedder TF, Fujimoto M.
- Journal Title
  
  Blood
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, T akehara K, T edder TF, Fujimoto M
- Journal Title
  
  Blood
  
  Volume: 121 Issue: 16 Pages: 3274-83
- DOI
  10.1182/blood-2012-11-465658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260, KAKENHI-PROJECT-24659523
[Journal Article] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013
- Author(s)
  Fujimoto M
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 72 Issue: 1 Pages: 151-153
- DOI
  10.1136/annrheumdis-2012-201736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591245, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260, KAKENHI-PROJECT-25461672
[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013
- Author(s)
  Fujimoto M, Matsushita T, Hamaguchi Y, Kaji K, Asano Y, Ogawa F, Yamaoka T, Fujikawa K, Tsukada T, Sato K, Echigo T, Hasegawa M, Takehara K.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: 72 Pages: 151-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M
- Journal Title
  
  Arthritis Rheum
  
  Volume: in press Issue: 6 Pages: 1624-35
- DOI
  10.1002/art.37933
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24659523, KAKENHI-PROJECT-25461686
[Journal Article] Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease.2013
- Author(s)
  Le Huu D, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Tedder TF, Fujimoto M.
- Journal Title
  
  Blood
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791260
[Journal Article] High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies2013
- Author(s)
  Hamaguchi Y, Matsushita T, Hasegawa M, Ueda-Hayakawa I, Sato S, Takehara K, Fujimoto M
- Journal Title
  
  Mod Rheumatol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Autoantibodies to small ubiquitin-like modifier activating enzymes in Japanese patients with dermatomyositis: comparison with a UK Caucasian cohort.2013
- Author(s)
  Fujimoto M, Matsushita T, Hamaguchi Y, Kaji K, Asano Y, Ogawa F, Yamaoka T, Fujikawa K, Tsukada T, Sato K, Echigo T, Hasegawa M, Takehara K.
- Journal Title
  
  Ann Rheum Dis.
  
  Volume: 72 Pages: 151-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791260
[Journal Article] Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.2013
- Author(s)
  Hasegawa M, Higashi K, Matsushita T, Hamaguchi Y, Saito K, Fujimoto M, Takehara K.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 70 Issue: 1 Pages: 34-41
- DOI
  10.1016/j.jdermsci.2013.01.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] BLNK expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells2013
- Author(s)
  Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Huu DL, Ishiura N, Naka K, Hirao A, Takehara K, Fujimoto M
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 131 Issue: 6 Pages: 1674-1682
- DOI
  10.1016/j.jaci.2013.01.044
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260
[Journal Article] B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.2013
- Author(s)
  Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Le Huu D, Ishiura N, Naka K, Hirao A, Takehara K, Fujimoto M.
- Journal Title
  
  J Allergy Clin Immunol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791260
[Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis.2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, Takehara K.
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 64 Pages: 3726-35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, T akehara K
- Journal Title
  
  Arthritis Rheum
  
  Volume: 64 Issue: 11 Pages: 3726-35
- DOI
  10.1002/art.34643
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390281, KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24220011
[Journal Article] Potential roles of interleukin 17A in the development of skin fibrosis.2012
- Author(s)
  Okamoto Y, Hasegawa M, Matsushita T, Hamaguchi Y, Huu DL, Iwakura Y, Fujimoto M, Takehara K.
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 64 Pages: 3726-3735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791260
[Journal Article] Host-derived MCP-1 and MIP-1αregulate protective anti-tumor immunity to localized and metastatic B16 melanoma2012
- Author(s)
  Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M
- Journal Title
  
  Am J Pathol
  
  Volume: 180(1) Issue: 1 Pages: 365-74
- DOI
  10.1016/j.ajpath.2011.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins2012
- Author(s)
  Fujimoto M, Hamaguchi Y, Kaji K, Matsushita T, Ichimura Y, Kodera M, Ishiguro N, Ueda-Hayakawa I, Asano Y, Ogawa F, Fujikawa K, Miyagi T, Mabuchi E, Hirose K, Akimoto N, Hatta N, Tsutsui K, Higashi A, Igarashi A, Seishima M, Hasegawa M, Takehara K
- Journal Title
  
  Arthritis Rheum
  
  Volume: 64(2) Issue: 2 Pages: 513-22
- DOI
  10.1002/art.33403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-24590185
[Journal Article] Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies : possible association with malignancy2012
- Author(s)
  Ichimura Y, Matsushita T, Hamaguchi Y, Kaji K, Hasegawa M, Tanino Y, Inokoshi Y, Kawai K, Kanekura T, Habuchi M, Igarashi A, Sogame R, Hashimoto T, Koga T, Nishino A, Ishiguro N, Sugimoto N, Aoki R, Ando N, Abe T, Kanda T, Kuwana M, Takehara K, Fujimoto M
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71(5) Issue: 5 Pages: 710-3
- DOI
  10.1136/annrheumdis-2011-200697
- NAID
  120004442395
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640, KAKENHI-PROJECT-23791260
[Journal Article] Use of serum clara cell 16-kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis2011
- Author(s)
  Hasegawa M, Fujimoto M, Hamaguchi Y, Matsushita T, Inoue K, Sato S, Takehara K
- Journal Title
  
  J Rheumatol
  
  Volume: 38(5) Issue: 5 Pages: 877-84
- DOI
  10.3899/jrheum.100591
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Association between nail-fold capillary findings and disease activity in dermatomyositis2011
- Author(s)
  Mugii N, Hasegawa M, Matsushita T, Hamaguchi Y, Horie S, Yahata T, Inoue K, Someya F, Fujimoto M, Takehara K
- Journal Title
  
  Rheumatology (Oxford)
  
  Volume: 50(6) Issue: 6 Pages: 1091-8
- DOI
  10.1093/rheumatology/keq430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice2011
- Author(s)
  Horikawa M, Minard-Colin V, Matsushita T, Tedder TF
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Issue: 11 Pages: 4268-4280
- DOI
  10.1172/jci59266
- Data Source
  KAKENHI-PROJECT-23791260
[Journal Article] Use of Serum Clara Cell 16-kDa (CC16) Levels as a Potential Indicator of Active Pulmonary Fibrosis in Systemic Sclerosis.2011
- Author(s)
  Hasegawa M, Fujimoto M, Hamaguchi Y, Matsushita T, Inoue K, Sato S, Takehara K.
- Journal Title
  
  J Rheumatol. 38(5)
  
  Pages: 877-884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890073
[Journal Article] Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study.2011
- Author(s)
  Hamaguchi Y, Kuwana M, Hoshino K, Hasegawa M, Kaji K, Matsushita T, Komura K, Nakamura M, Kodera M, Suga N, Higashi A, Ogusu K, Muro Y, et al. （全37名中17番目）
- Journal Title
  
  Arch. Dermatol.
  
  Volume: 147 Issue: 4 Pages: 391-398
- DOI
  10.1001/archdermatol.2011.52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591618, KAKENHI-PROJECT-23591640
[Journal Article] Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells.2011
- Author(s)
  Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, Szabolcs PM, Bernstein SH, Magro CM, Williams AD, Hall RP, St Clair EW, Tedder TF.
- Journal Title
  
  Blood. 117(2)
  
  Pages: 530-541
- NAID
  120005756479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890073
[Journal Article] Identifying regulatory B cells (B10 cells) that produce IL-10 in mice.2011
- Author(s)
  Matsushita T, Tedder TF.
- Journal Title
  
  Methods Mol Biol. 677
  
  Pages: 99-111
- Data Source
  KAKENHI-PROJECT-22890073
[Journal Article] Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production2011
- Author(s)
  Maeda S, Fujimoto M, Matsushita T, Hamaguchi Y, Takehara K, Hasegawa M
- Journal Title
  
  Am J Pathol
  
  Volume: 179(5) Issue: 5 Pages: 2360-9
- DOI
  10.1016/j.ajpath.2011.07.048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591640
[Journal Article] Serum chemokine and cytokine levelsas indicators of disease activity in patients with systemic sclerosis.2011
- Author(s)
  Hasegawa M, Fujimoto M, Matsushita T, Hamaguchi Y, Takehara K, Sato S.
- Journal Title
  
  Clin Rheumatol. in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890073
[Journal Article] haracterization of a Rare IL-10-Competent B Cell Subset in Man That Parallels Mouse Regulatory B10 Cells2011
- Author(s)
  Iwata Y*, Matsushita T*, Horikawa, DiLillo, Yanaba, Venturi, Szabolcs, Bernstein, Magro, Williams, Hall, St.Clair, and Tedder TF
- Journal Title
  
  Blood
  
  Volume: 117 Issue: 2 Pages: 530-41
- DOI
  10.1182/blood-2010-07-294249
- Data Source
  KAKENHI-PROJECT-23791260
[Journal Article] Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.2010
- Author(s)
  Matsushita T, Horikawa M, Iwata Y, Tedder TF.
- Journal Title
  
  J Immunol. 185(4)
  
  Pages: 2240-2252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22890073
[Presentation] BAFF inhibition attenuates fibrosis in bleomycin-induced scleroderma model via modulating the regulatory and effector B-cell balance2018
- Author(s)
  Matsushita T, Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K
- Organizer
  American College of Rheumatology (ACR) 2018 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10147
[Presentation] Tumor-infiltrating CD5+ regulatory B1 cells suppress melanoma tumor immunity via inhibiting cytokine production of tumor-infiltrating CD8+ T cells2018
- Author(s)
  Tadahiro Kobayashi, Takashi Matsushita, Yasuhito Hamaguchi, Manabu Fujimoto, and Kazuhiko Takehara
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18449
[Presentation] CD5+ regulatory B1 cells inhibit melanoma tumor immunity2017
- Author(s)
  Tadahiro Kobayashi, Takashi Matsushita, Yasuhito Hamaguchi, Manabu Fujimoto, and Kazuhiko Takehara
- Organizer
  The 42st Annual Meeting of The Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18449
[Presentation] 強皮症：最近の話題　全身性強皮症における制御性B細胞の役割2016
- Author(s)
  松下貴史
- Organizer
  第115回日本皮膚科学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] Dual aspects of B cells in tumor immunity; B cells are capable of positive and negative regulation for tumor immunity against B16F10 melanoma2016
- Author(s)
  Tadahiro Kobayashi, Takashi Matsushita, Yasuhito Hamaguchi, Minoru Hasegawa, Manabu Fujimoto, and Kazuhiko Takehara
- Organizer
  The 41st Annual Meeting of The Japanese Society for Investigative Dermatology
- Place of Presentation
  仙台国際センター（仙台）
- Year and Date
  2016-12-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18449
[Presentation] 抗トポイソメラーゼⅠ抗体陽性の小児限局性強皮症の１例2015
- Author(s)
  竹原和彦，清水恭子，松下貴史，濱口儒人
- Organizer
  日本皮膚科学会新潟地方会
- Place of Presentation
  新潟
- Year and Date
  2015-04-05
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] Decreased Levels of Regulatory B cells in Patients with Systemic Sclerosis: Association witn autoantibody production2015
- Author(s)
  Matsushita T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K
- Organizer
  45th Annual ESDR Meeting
- Place of Presentation
  オランダ
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] FTY720 ameliorates murine Scl-cGVHD by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into the skin.2013
- Author(s)
  Matsushita T, Le Huu D, Takehara K, Fujimoto M
- Organizer
  The American Association of Immunologists
- Place of Presentation
  Honolulu, USA
- Data Source
  KAKENHI-PROJECT-25461686
[Presentation] PI3K-Akt pathway modulates IL-10 producing regulatory B cell2012
- Author(s)
  Matsushita T, Le Huu D, Fujimoto M, Takehara K
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  Okinawa, LOISIR HOTEL & SPA TOWER NAHA
- Year and Date
  2012-12-07
- Data Source
  KAKENHI-PROJECT-23791260
[Presentation] PI3K-Akt pathway modulates IL-10 producing regulatory B cell.2012
- Author(s)
  Matsushita T
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  沖縄、ロワジールホテル＆スパタワー那覇
- Data Source
  KAKENHI-PROJECT-23791260
[Presentation] A double-edge sword in B cell depletion therapy for autoimmune disease2010
- Author(s)
  Takashi Matsushita、Manabu Fujimoto、Thomas F.Tedder, Kazuhiko Takehara
- Organizer
  第35回日本研究皮膚科学会
- Place of Presentation
  和歌山県民文化会館(和歌山市)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22890073
[Presentation] Blockade of Syk Ameliorates the Development of Sclerodermatous Chronic Graft-Versus-Host Disease.
- Author(s)
  Matsushita T, Le Huu D, Kimura H, Date M, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K
- Organizer
  ESDR 2014
- Place of Presentation
  Copenhagen
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26461680
[Presentation] Blockade of Syk Ameliorates the Development of Sclerodermatous Chronic Graft-Versus-Host Disease.
- Author(s)
  Matsushita T, Le Huu D, Kimura H, Date M, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K
- Organizer
  ESDR 2014
- Place of Presentation
  Copenhagen
- Year and Date
  2014-09-11 – 2014-09-23
- Data Source
  KAKENHI-PROJECT-25461686

1. TAKEHARA KAZUHIKO (50142253)

# of Collaborated Projects: 3 results

# of Collaborated Products: 20 results
2. Yamamoto Yasuhiko (20313637)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HASEGAWA Minoru (50283130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
4. Kobayashi Tadahiro (20746383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 棟居聖一 (10399040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木村久美 (60409472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 藤原浩 (30252456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 篁俊成 (00324111)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 和田泰三 (30313646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 堀江昭史 (30535836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大黒多希子 (30767249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 谷内江昭宏 (40210281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 堀家慎一 (40448311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 服部明 (50300893)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 河崎洋志 (50303904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 藤原智子 (60310744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 荒木慶彦 (70250933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小野政徳 (70348712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 渡会浩志 (70415339)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 鏡京介 (80748616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 飯塚崇 (90748617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 伊藤潤哉 (30454143)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 稲木紀幸 (40436837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 松本勲 (80361989)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 八木真太郎 (60447969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 前田大地 (30585500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 松本多圭夫 (30748629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 水本泰成 (00420331)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 西尾健資 (70303790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 藤本学

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
31. 室慶直

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 桑名正隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Matsushita Takashi 松下 貴史

MATSUSHITA Takashi 松下 貴史

松下 貴史 マツシタ タカシ

Research Projects

Research Products

Co-Researchers

Development of selective GM-CSF-producing effector B cell inhibition therapy in systemic sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

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全身性強皮症におけるＢ細胞の包括的解析Principal Investigator

Principal Investigator

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Elucidation of anti-inflammatory functions by oxytocin

Principal Investigator

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新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用

Principal Investigator

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Research Institution

Development of a Novel Treatment for Scleroderma by Regulation of Cytokine-Producing B CellsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

The role of Effector B cell in Systemic Sclerosis

Principal Investigator

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A role of regulatory B cell in tumor immunity

Principal Investigator

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The role of cytokine producing B cell in scleroderma mouse modelPrincipal Investigator

Principal Investigator

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The role of Syk in the pathogenesis of systemic sclerosis

Principal Investigator

Project Period (FY)

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The role of regulatory B cell in the pathogenesis of systemic sclerosisPrincipal Investigator

Principal Investigator

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Research Institution

The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models

Principal Investigator

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Analysis of PI3K signaling role in regulatory B cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Research of regulatory B cell role in sclerodermatous GVHD mousePrincipal Investigator

Principal Investigator

Matsushita Takashi 松下貴史

MATSUSHITA Takashi 松下貴史

松下貴史マツシタタカシ