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YAMAGUCHI Kouji  山口 幸二

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… Alternative Names

山口 幸二  ヤマグチ コウジ

YAMAGUCHI Koji  山口 幸二

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Researcher Number 50191226
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2015: 産業医科大学, 医学部, 特任教授
2013: 産業医科大学, 医学部, 教授
2009 – 2010: 産業医科大学, 医学部, 教授
2009 – 2010: 産業医科大学, 第1外科, 教授
2008 – 2010: Kyushu University, 大学院・医学研究院, 共同研究員 … More
2006: Kyushu University, Faculty of Medical Sciences, Associate Professor, 大学院医学研究院, 助教授
2002 – 2005: Graduate School of Medical Sciences, Ass. Prof., 大学院・医学研究院, 助教授
2002: 九州大学, 医学部附属病院, 助教授
2000 – 2001: 九州大学, 医学部・付属病院, 講師
2000 – 2001: 九州大学, 医学部・附属病院, 講師
1997 – 1999: 九州大学, 医学部, 講師
1995 – 1997: 九州大学, 医学部, 助手
1991: 九州大学, 医学部, 助手
1987: Kyushu University Faculty of Medicine,Assistant, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Digestive surgery / Digestive surgery
Except Principal Investigator
Digestive surgery / Digestive surgery / General surgery
Keywords
Principal Investigator
Sonic Hedgehog / NFkB / Hedgehog / 膵癌 / invasion / obstructive pancreat it is / inflammation / pancreatic cancer / IL1-β / 浸潤 … More / 閉塞性膵炎 / 炎症 / 形態形成 / gallbladder carcinoma / inflammation and carcinoma / oxidative stress / pancreaticobiliary maljunction / DNA傷害 / 細胞回転 / エイコサイド / 炎症性サイトカイン / 膵胆管合流異常症 / 胆嚢癌 / 炎症と発癌 / 酸化的ストレス / 膵・胆管合流異常 / hepatic energy / warm ischemia of the liver / phosphoenolpyruvate / 肝虚血・再環流障害 / 解糖系 / エネルギーチャージ / ラット / 肝虚血再環流 / ホスホエノールピルビン酸 / 肝虚血再還流 / 肝虚血再還流障害 / PEP / 薬剤耐性 / 特異的 / γ-secretase / M集積 / G2 / Notch / g-secretase / 細胞増殖 / Nicastrin / Presenilin-2 / Presenilin-1 / ガンマセクレターゼ複合体 / 細胞周期 / 分子標的治療 / アポトーシス / Taxane / GS 阻害剤 / gamma secretase (GS)複合体 / 大腸癌 … More
Except Principal Investigator
肝切除 / bilirubin / ビリルビン / 胆汁酸合成 / アポトーシス / 細胞増殖 / カルシウムシグナリング / Cyclopamine / EMT / Hedgehog / 浸潤 / 尿 / 抗酸化剤 / 酸化ストレス / bile acid synthesis / 7αヒドロキシコレステロール / hepatectomy / 肝予備能 / 肝再生 / 閉塞性黄疸 / oxidative stress / sepsis / 活性酸素 / 敗血症 / 大腸癌 / イノシトール3リン酸受容体 / 胃癌 / IP3レセプター / Epidemiology / Intrahepatic calculi / Hapatolithiasis / 胆管狭窄 / 結石所在部位 / 発生年齢 / 全胆石症に対する頻度 / 肝内結石症 / colon cancer / breast cancer / pancreatic cancer / invasion / cancer / 細胞変形能 / 微小管 / シクロパミン / 乳癌 / 膵癌 / 癌 / 8-hydroxy deoxyguanosine / acrolein / lipid peroxides / biopyrrin / jaundice / hyperbaric oxygen / superoxide / 高圧酸素療法 / 黄疸 / 8水酸化デオキシグアノシン / アクロレイン / 過酸化脂質 / バイオピリン / 黄疽 / 高圧酸素 / gene transfection / biliary cancer / microgravity / 3-D culture / bile duct / artificial biliary duct / 胆管癌 / 胆管上皮 / 人工胆管 / 胆管 / 遺伝子導入 / 胆道癌 / 低重力培養 / 三次元培養 / 人工胆菅 / 胆菅 / Transcriptional factor / Cell cycle / Cyclin dependent kinase / Cyclin / Liver regeneration / Biliary drainage / Liver cirrhosis / Obstructive jaundice / 転写因子AP-1 / EBP / 転写因子C / MAPキナーゼ / 増殖因子 / サイクリンE / 萎縮 / 門脈結紮術 / 腸管内胆汁 / 転写因子 / 細胞周期 / サイクリン依存性キナーゼ / サイクリン / 肝切除後肝再生 / 胆汁瘻 / 肝硬変 / complication / surgery / severity / urine / antioxidant / 合併症 / 外科手術 / 重症度 / rat / regulation mechanism / bile acid metabolism / intestinal facor / 7α-hydroxycholesterol / ラット / 調節機構 / 胆汁酸代謝 / 腸管因子 / cholestyramine / liver regeneration / hepatic functional reserve / 7α -hydroxycholesterol / 負荷試験 / コレスチラミン / reperfusion injury / ischemia / gadolinium / biliary drainage / obstructive jaundice / 他臓器合併肝切除 / Kupffer細胞 / 他臓器合併切除 / 虚血再灌流障害 / ガドリニウム / 肝切除術 / 減黄術 / heme oxygenase / intestine / ヘムオキシゲナーゼ / 小腸 / Oxi-cholesterolalveol / Bile acid synthesis / 7alpha-Hydroxycholesterol / Carcinogenesis / Cholesterol / コレステロ-ル酸化物 / 7αーhydroxycholesterol / コレステロ-ル / 酸化コレステロール / 胆汁酸生合成 / 7α-水酸化コレステロール / 発癌 / コレステロール / InsP3R / 予後 / イノシトール3リン酸 / IP3 レセプター / 抗癌剤 Less
  • Research Projects

    (18 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (40 People)
  •  Expression of Inositol 1,4,5-trisphosphate receptors (InsP3Rs) in gastric cancer patients

    • Principal Investigator
      SHIBAO Kazunori
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Identification and clinical application of colon cancer-specific gamma-secretase-targeting moleculesPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Kouji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  The role of InsP3 receptor expression in gastric cancer patients

    • Principal Investigator
      SHIBAO Kazunori
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  The role of InsP3 receptor expression in colorectal cancer patients and its relation to metastasis and neo-adjuvant chemotherapy

    • Principal Investigator
      HIRATA Keiji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Occupational and Environmental Health, Japan
  •  Development of pancreatic cancer therapy and prevention using morphogen as a target signaling pathwayPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Kouji
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Development of new cancer therapy by regulating cytoskeleton and cancer-cell transformation

    • Principal Investigator
      NAKAMURA Masafumi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Effect of hyperbaric oxygen on hyperbiliri.ibinemia from the viewpoint of antioxidant activity of bilirubin

    • Principal Investigator
      SHIMIZU Shuji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Arificial biliary duct model for surgical therapeutic material and research material for biliary cancer

    • Principal Investigator
      MORISAKI Takashi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Kyushu University
  •  Molecular analysis of bile duct cancer associated with PBMPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Koji
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Investigation on the intestinal factor(s) of regulational mechanism of bile acid synthesis

    • Principal Investigator
      KUROKI Shoji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Increased urinary excretion of bilirubin oxidative metabolites in septic patients: a new marker for ocidative stress in vivo

    • Principal Investigator
      SHIMIZU Shuji
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Establishment of hepatic reserve function and molecular biological analysis of liver function after hepatectomy

    • Principal Investigator
      CHIJIIWA Kazuo
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Miyazaki Medical College
      Kyushu University
  •  Clinical significance of serum 7α-hydroxycholesterol level and hepatic functional reserve in patients who undergo partial hepatectomy

    • Principal Investigator
      KUROKI Syoji
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  The induction of heme oxygenese-1 in intestinal mucosa of septic rat

    • Principal Investigator
      SHIMIZU Shuji
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Kyushu University
  •  The total evaluation of the functions of microsome, mitochondria, and reticuloendothelial systems in the liver

    • Principal Investigator
      CHIJIIWA Kazuo
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Phshoenol/pyruvate prevents the decline in hepatic ATP and energy charge afte ischemia and reperfusion injyury in ratsPrincipal Investigator

    • Principal Investigator
      YAMAGUCHI Koji
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kyushu University
  •  Metabolism of intravenously administered 7alpha -hydroxycholesterol-3beta-stearate in the hamster.

    • Principal Investigator
      KUROKI Syoji
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      KYUSHU UNIVERSITY
  •  Clinicopathological study on hepatolithiasis in China and follow up study

    • Principal Investigator
      NAKAYAMA Fumio
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for Overseas Scientific Research
    • Research Institution
      Kyushu University

All 2010 Other

All Journal Article

  • [Journal Article] Gamma-secretase complexes regulate the response of human pancreatic ductal adenocarcinoma cells to taxanes.2010

    • Author(s)
      Tasaka T, Akiyoshi T, Yamaguchi K, Tanaka M, Onishi H, Katano M
    • Journal Title

      Anticancer Res 30

      Pages: 4999-5010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390361
  • [Journal Article] The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma2010

    • Author(s)
      Shibao K., Hirata K, Yamaguchi K., et al.
    • Journal Title

      Cell Calcium

      Volume: 48 Pages: 315-323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591598
  • [Journal Article] The type III inositol 1, 4, 5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma2010

    • Author(s)
      Shibao K., Hirata K, Yamaguchi K., et al.
    • Journal Title

      Cell Calcium

      Volume: 48 Pages: 315-323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591583
  • [Journal Article] Gamma-secretase complexes regulate the responses of human pancreatic ductal adenocarcinoma cells to taxanes2010

    • Author(s)
      Tasaka T, Yamaguchi K, et al.
    • Journal Title

      Anticancer Research

      Volume: 30 Pages: 4999-5010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390361
  • [Journal Article] The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma2010

    • Author(s)
      Shibao K, Fiedler MJ, Nagata J, Minagawa N, Hirata K, Nakayama Y, Iwakiri Y, Nathanson MH, Yamaguchi K
    • Journal Title

      Cell Calcium 48(6)

      Pages: 315-323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591598
  • [Journal Article] The type III inositol 1,4,5-trisphosphate receptor is associated with aggressiveness of colorectal carcinoma.2010

    • Author(s)
      Shibao K, Fiedler MJ, Nagata J, Minagawa N, Hirata K, Nakayama Y, Iwakiri Y, Nathanson MH, Yamaguchi K
    • Journal Title

      Cell Calcium. 48(6)

      Pages: 315-323

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591583
  • [Journal Article] Nuclear Factor kB Contributes to Hedgehog Signaling Pathway Activation through Sonic Hedgehog Induction in Pancreatic Cancer

    • Author(s)
      Nakashima H, Nakamura M, Yamaguchi H, et al.
    • Journal Title

      Cancer Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16591326
  • 1.  CHIJIIWA Kazuo (90179945)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 2.  KUROKI Syoji (30215090)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  SHIMIZU Shuji (70274454)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  KATANO Mitsuo (10145203)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 5.  NAKAMURA Masafumi (30372741)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 6.  NAKANO Kenji (00315061)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  SHIBAO Kazunori (10330987)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 4 results
  • 8.  YAMAGUCHI Tokio (30134745)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  MORISAKI Takashi (90291517)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  HIRATA Keiji (70269059)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 11.  ICHIMIYA Hitoshi (10183170)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  NOSHIRO Hirokazu (90301340)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  永田 直幹 (80200377)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 14.  UEDA Junji
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  高松 祐治
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  ONISHI Hideya (30553276)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 17.  SATOH Norihiro (20423527)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KOJIMA Masayuki (90380394)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  KUBO Makoto (60403961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  HIGURE Aiichiro (20289581)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  MATAYOSHI Nobutaka (00721630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  HAMASAKI Naotaka (00091265)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  MAKINO Ichiro (30347059)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  KAI Masahiro (40264379)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  KONDO Kazuhiro (10244196)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  UCHIYAMA Akihiko (20294936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  MATSUDA Takehisa (60142189)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  TANAKA Masao (30163570)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  NOMURA Masatoshi (30315080)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  NAKAYAMA Fumio (70038652)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  MIYAZAKI Koji (30159173)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  OKAMOTO Shuichiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  NAITO Tokio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  IGIMI Hirotsune
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  KAWAMOTO Masahiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  亀岡 宣久
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  高松 裕治
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  園田 幸生
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  小林 毅一郎
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  大塚 隆生
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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