Kuno Atsushi 久野敦

… Alternative Names

KUNO Atsushi 久野敦

久野敦クノアツシ

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Researcher Number	50302287
Other IDs
Affiliation (Current)	2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長
Affiliation (based on the past Project Information) *help	2020 – 2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長 2017 – 2019: 国立研究開発法人産業技術総合研究所, 生命工学領域, 上級主任研究員 2015 – 2016: 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 2014: 独立行政法人産業技術総合研究所, 糖鎖創薬技術研究センター, 上級主任研究員 2013: 独立行政法人産業技術総合研究所, 糖鎖医工学研究センター, 上級主任研究員 … More 2012: 独立行政法人産業技術総合研究所, 糖鎖医工学研究センター, 主任研究員 2010: 独立行政法人産業技術総合研究所, 糖鎖医工学研究センター, 主任研究員 2009: 独立行政法人産業技術総合研究所, 糖銷医工学研究センター, 主任研究員 2007 – 2008: National Agriculture and Food Research Organization, National Institute of Advanced Industrial Science and Technology, Research Center for Medical Glycoscience, Researcher 2006: 独立行政法人産業技術総合研究所, 糖鎖工学研究センター, 研究員 2004: 産業技術総合研究所, 研究員 2003: 産業技術総合研究所, 糖鎖工学研究センター, 研究員 2001 – 2002: 山形大学, 理学部, 助手 Less
Review Section/Research Field	Except Principal Investigator Applied molecular and cellular biology / Basic Section 48040:Medical biochemistry-related / Basic Section 49030:Experimental pathology-related / Basic Section 54010:Hematology and medical oncology-related / Laboratory medicine / Digestive surgery / Functional biochemistry / Applied materials science/Crystal engineering
Keywords	Except Principal Investigator 糖鎖 / NMR / バイオマーカー / 糖認識ドメイン / レクチン / 蛋白質 / 肝線維化 / Aeropyrum pernix K1 / 肝がん / トリプルネガティブ乳がん … More / 癌幹細胞 / 癌微小環境 / 腫瘍マーカー / 巨核球 / 血小板 / 骨髄増殖性腫瘍 / 小胞体ストレス応答因子 / マイクロアレイ / 臨床 / 探索的研究 / 動脈瘤 / 腹部大動脈瘤 / 糖鎖蛋白 / 動脈硬化 / 大動脈瘤 / aortic aneurysm / atherosclerosis / 分離培養 / 肝実質細胞 / Galactin 3 / T細胞 / 糖蛋白 / 肝星細胞 / マクロファージ / galectin 3 / WFA-M2BP / carbohydrate recognition domain / lectin / sugar / protein / Tryptophan tRNA / Proline tRNA / Threonine tRNA / Evolution / Aminoacyl-tRNA synthetase / Archaea / Archaea identity / T7RNAポリメラーゼ / プロリル-tRNA合成酵素 / in vitro転写反応 / チロシンtRNA / チロシル-tRNA合成酵素 / 分子進化 / トリプトファンRNA / トリプトファニル-tRNA合成酵素 / Aeropyrum pernix / トリプトファンtRNA / プロリンtRNA / トレオニンtRNA / 進化 / アミノアシル-tRNA合成酵素 / 古細菌 / tRNAアイデンティティー / レーザー作用 / 発光タンパク質溶液 Less

癌細胞の代謝リプログラミング依存的な糖鎖修飾と癌微小環境応答の解明
- Principal Investigator
  
  川西邦夫
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  University of Tsukuba
骨髄増殖性腫瘍における小胞体ストレス応答分子の細胞腫瘍性に及ぼす影響の解明
- Principal Investigator
  
  森下総司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Juntendo University
肝線維化糖鎖バイオマーカーの糖鎖異性化機構と分子機能の相関解明
- Principal Investigator
  
  溝上雅史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  National Center for Global Health and Medicine
Exploratory investigation for new indicators based on comprehensive glycan-based analysis of arteriosclerotic aortic aneurysms
- Principal Investigator
  
  Sugiura Tomonori
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagoya City University
The biological analysis of sugar chain signal between hepatic stelate cells and macrophages in the progression of liver fibrosis.
- Principal Investigator
  
  Shirabe Ken
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Gunma University
  Kyushu University
Structural biological studies on the sialic acid-binding mechanism of R-type lectin mutant
- Principal Investigator
  
  HEMMI Hikaru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Agriculture and Food Research Organization
Structural biological studies on the sugar-binding mechanism of R-type lectin having a specific sugar-binding activity
- Principal Investigator
  
  HEMMI Hikaru
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Agricultural Research Organization
Structural biological studies on the sugar-binding mechanism of two sugar-binding domains having different physiological functions
- Principal Investigator
  
  HIKARU Hemmi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Agricultural Research Organization
発光タンパク質溶液におけるレーザー作用発現に関する基礎研究
- Principal Investigator
  
  大西彰正
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied materials science/Crystal engineering
- Research Institution
  Yamagata University
Study on tRNA recognition mechanism by aminoacyl-tRNA synthetase from archaea
- Principal Investigator
  
  HASEGAWA Tsunemi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Yamagata University

All 2017 2016 2014 2013 2012 2010 2009 2008 2007 2006

All Journal Article Presentation

[Journal Article] Hepatic stellate cells secrete WFA+ -M2BP; its role in biological interactions with Kupffer cells.2017
- Author(s)
  Bekki Y,, Yoshizumi T, Shimoda S, Itoh S, Harimoto N, Ikegami T, Kuno A, Narimatsu H, Shirabe K, Maehara Y.
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 32 Issue: 7 Pages: 1387-1393
- DOI
  10.1111/jgh.13708
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04932, KAKENHI-PROJECT-15K10167
[Journal Article] NMR structure and dynamics of the C-terminal domain of R-type lectin from the earthworm Lumbricus terrestris2013
- Author(s)
  逸見　光、久野　敦、平林　淳
- Journal Title
  
  FEBS Journal
  
  Volume: 280 Issue: 1 Pages: 70-82
- DOI
  10.1111/febs.12050
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24580500
[Journal Article] NMR studies on the interaction of sugars with C-terminal domain of an R-type lectin from the earthworm Lumbricus terrestris2009
- Author(s)
  Hikaru Hemmi, Atsushi Kuno, Shigeyasu Ito, Ryuichiro Suzuki, Tsunemi Hasegawa, Jun Hirabayashi
- Journal Title
  
  FEBS Journal Vol.276
  
  Pages: 2095-2105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580373
[Journal Article] NMR studies on the interaction of sugars with the C-terminal domain of an R-type lectin from the earthworm Lumbricus terrestris2009
- Author(s)
  逸見光、久野敦, 他4名
- Journal Title
  
  FEBS Journal 276
  
  Pages: 2095-2105
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] 肝星細胞の新しいバイオマーカーWFA-M2BPの肝臓外科における意義と展望2016
- Author(s)
  調　　憲、別城悠樹、戸島剛男、吉屋匠平、伊藤心二、池上　徹、吉住朋晴、間野洋平、考藤達哉、溝上雅史、久野　敦、成松　久、前原喜彦
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H04932
[Presentation] 新たな肝星細胞のバイオマーカーである血清糖タンパクWFA(+)-M2BPの肝線維化進展における役割2016
- Author(s)
  別城悠樹、調　　憲、坂田一仁、下川雅弘、吉田佳弘、今井大祐、王　歓林、木村光一、伊藤心二、播本憲史、池上　徹、内山秀昭、吉住朋晴、間野洋平、久野　敦、成松　久、溝上雅史、前原喜彦
- Organizer
  第116回日本外科学会定期学術集会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2016-04-14
- Data Source
  KAKENHI-PROJECT-15H04932
[Presentation] 遊離状態および糖結合状態におけるミミズ由来R型レクチン改変体のシアル酸糖結合メカニズムに関するNMR解析2014
- Author(s)
  逸見　光、久野　敦、海野幸子、平林　淳
- Organizer
  第53回NMR討論会
- Place of Presentation
  大阪大学コンベンションセンター（大阪府吹田市）
- Year and Date
  2014-11-06
- Data Source
  KAKENHI-PROJECT-24580500
[Presentation] NMR analysis of a sialic acid-binding mutant from an R-type lectin in the sugar-free state or in the sugar-bound states2014
- Author(s)
  逸見　光、久野　敦、平林　淳
- Organizer
  26th International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Hyatt Regency Dallas（アメリカ合衆国テキサス州）
- Year and Date
  2014-08-25
- Data Source
  KAKENHI-PROJECT-24580500
[Presentation] 分子進化工学的手法によるミミズ由来R型レクチン改変体のシアル酸糖結合メカニズムに関するNMR解析2013
- Author(s)
  逸見　光、久野　敦、海野幸子、平林　淳
- Organizer
  第52回NMR討論会
- Place of Presentation
  石川県立音楽堂（石川県）
- Data Source
  KAKENHI-PROJECT-24580500
[Presentation] NMR studies on a novel sialic acid-binding lectin mutant from the C-terminal domain of an R-type lectin from earthworm2013
- Author(s)
  逸見　光、久野　敦、平林　淳
- Organizer
  5th Asia-Pacific NMR Symposium
- Place of Presentation
  Brisbane Convention and Exhibition Centre（オーストラリア）
- Data Source
  KAKENHI-PROJECT-24580500
[Presentation] ミミズ由来R型レクチンC末端ドメインの異なったラクトース結合状態でのNMR解析2012
- Author(s)
  逸見　光、久野　敦、海野幸子、平林　淳
- Organizer
  第51回NMR討論会
- Place of Presentation
  ウインクあいち（愛知県）
- Data Source
  KAKENHI-PROJECT-24580500
[Presentation] NMR studies on the complex of the C-terminal domain of R-type lectin from earthworm with lactose2012
- Author(s)
  逸見　光、久野　敦、平林　淳
- Organizer
  25th International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Lyon Convention Centre（フランス）
- Data Source
  KAKENHI-PROJECT-24580500
[Presentation] NMR structure and dynamics of C-terminal domain of R-type lectin from earthworm in the lactose-binding state2010
- Author(s)
  逸見光、久野敦、海野幸子、平林淳
- Organizer
  24th International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Cairns Convention Centre(オーストラリア)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] NMR structure and dynamics of C-terminal domain of R-type lectin from earthworm in the lactose-binding state2010
- Author(s)
  逸見光、久野敦, 他2名
- Organizer
  24^<th> International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Cairns Convention Centre(オーストラリア)
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] ミミズ由来R型レクチンC末端ドメインのラクトースとの結合状態でのNMR構造2010
- Author(s)
  逸見光、久野敦、海野幸子、平林淳
- Organizer
  第49回NMR討論会
- Place of Presentation
  タワーホール船堀(東京)
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] NMR studies for the binding of lactose with C-terminal domain of an R-type lectin from the earthworm2009
- Author(s)
  逸見光、久野敦、海野幸子、平林淳
- Organizer
  The 3rd Asia-Pacific NMR Symposium
- Place of Presentation
  Ramada Plaza Jeju Hotel(韓国)
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] NMR studies for the binding of lactose with the C-terminal domain of an R-type lectin from the earthworm2009
- Author(s)
  逸見光、久野敦, 他2名
- Organizer
  The 3^<rd> Asia-Pacific NMR Symposium
- Place of Presentation
  Ramada Plaza Jeju Hotel(韓国)
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] ミミズ由来R型レクチンC末端ドメインと糖との結合様式に関するNMR解析2009
- Author(s)
  逸見光、久野敦、海野幸子、平林淳
- Organizer
  第48回NMR討論会
- Place of Presentation
  九州大学馬出病院キャンパス医学部百年講堂(福岡)
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] NMRによるミミズ由来R型レクチンC末端ドメインの特異的な糖結合活性に関する研究2008
- Author(s)
  逸見光, 久野敦, 他2名
- Organizer
  第47回NMR討論会
- Place of Presentation
  筑波大学大学会館講堂
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] NMR structure of C-terminal domain of R-type lectin from earthworm in the sugar-free state and its interaction with sugars2008
- Author(s)
  逸見光, 久野敦, 他4名
- Organizer
  23^<rd> International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Sheraton San Diego Hotel & Marina (アメリカ合衆国)
- Year and Date
  2008-08-25
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] NMR structure of C-terminal domain of R-type lectin from earthworm in the sugar-free state and its interaction with sugars2008
- Author(s)
  逸見光、久野敦、伊藤茂泰、鈴木龍一郎、長谷川典巳、平林淳
- Organizer
  23rd International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Sheraton San Diego Hotel & Marina(アメリカ合衆国)
- Year and Date
  2008-08-25
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] NMRによるミミズ由来R 型レクチンC末端ドメインの特異的な糖結合活性に関する研究2008
- Author(s)
  逸見光、久野敦、海野幸子、平林淳
- Organizer
  第47回NMR討論会
- Place of Presentation
  筑波大学大学会館講堂
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-20580373
[Presentation] Interaction of C-terminal domain of a R-type lectin from earthworm with some sugars2007
- Author(s)
  Hikaru Hemmi, Atsushi Kuno, Shigeyasu Ito, Ryuichiro Suzuki, Tsunemi Hasegawa, Jun Hirabayashi
- Organizer
  The 46th Annual Meeting of the NMR Society of Japan
- Place of Presentation
  Sapporo Convention Center
- Year and Date
  2007-09-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580342
[Presentation] NMR invertigation of the interaction of the C-terminal domain of a novel galactose・binding protein from earthworm with some sugars2007
- Author(s)
  Hikaru Hemmi, Atsushi Kuno, Shigeyasu Ito, Ryuichiro Suzuki, Tsunemi Hasegawa, Jun Hiirabayashi
- Organizer
  The 16th Triennial Conference for the International Society of Magnetic Resonance
- Place of Presentation
  Howard Beach Resort Kenting Taiwan
- Year and Date
  2007-10-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580342
[Presentation] NMR investigation of the interaction of the C-terminal domain of a novel galactose-binding protein from earthworm with some sugars2007
- Author(s)
  逸見光、久野敦, 他4名
- Organizer
  The 16^<th> Triennial Conference for the International Society of Magnetic Resonance
- Place of Presentation
  Howard Beach Resort Kenting(台湾ケンチン)
- Year and Date
  2007-10-15
- Data Source
  KAKENHI-PROJECT-18580342
[Presentation] ミミズ由来R型レクチンのC末端糖結合ドメインの糖との相互作用に関する研究2007
- Author(s)
  逸見光、久野敦, 他4名
- Organizer
  第46回NMR討論会
- Place of Presentation
  札幌コンベンションセンター(北海道札幌市)
- Year and Date
  2007-09-11
- Data Source
  KAKENHI-PROJECT-18580342
[Presentation] NMR studies on the C-terminal domain of a novel glaactose・binding protein from earthworm2006
- Author(s)
  Hikaru Hemmi, Atsushi Kuno, Shigeyasu Ito, Tsunemi Hasegawa, Jun Hirabayashi
- Organizer
  22nd International Conference on Magnetic Resonance in Biological Systems
- Place of Presentation
  Gottingen Germany
- Year and Date
  2006-08-24
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580342
[Presentation] Investigations on the interaction between sugars and the C-terminal domain of a novel galactose-binding protein from earthworm2006
- Author(s)
  Hikaru Hemmi, Atsushi Kuno, Shigeyasu Ito, Ryuichiro Suzuki, Tsunemi Hasegawa, Jun Hirabayashi
- Organizer
  The 45th Annual Meeting of the NMR Society of Japan
- Place of Presentation
  Kyoto University Centennial Hall
- Year and Date
  2006-11-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580342

1. HEMMI Hikaru (70353993)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
2. HIRABAYASHI Jun (40156691)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. HASEGAWA Tsunemi (60095023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Shirabe Ken (70264025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. Sugiura Tomonori (60535235)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 大西彰正 (90261677)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 佐々木実 (10116593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 下田慎治 (30279319)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 成松久 (40129581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 前原喜彦 (80165662)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 吉住朋晴 (80363373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 池上徹 (80432938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 佐藤隆 (90371046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 山下洋市 (00404070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 川中博文 (10363334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 池田哲夫 (60585701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 森下総司 (10635866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 小松則夫 (50186798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 川西邦夫 (00578750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HENGPHASATPORN Kowit (90961681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 溝上雅史 (40166038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kuno Atsushi 久野 敦

KUNO Atsushi 久野 敦

久野 敦 クノ アツシ

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[Journal Article] Hepatic stellate cells secrete WFA+ -M2BP; its role in biological interactions with Kupffer cells.2017

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[Journal Article] NMR structure and dynamics of the C-terminal domain of R-type lectin from the earthworm Lumbricus terrestris2013

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[Journal Article] NMR studies on the interaction of sugars with C-terminal domain of an R-type lectin from the earthworm Lumbricus terrestris2009

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[Journal Article] NMR studies on the interaction of sugars with the C-terminal domain of an R-type lectin from the earthworm Lumbricus terrestris2009

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[Presentation] 肝星細胞の新しいバイオマーカーWFA-M2BPの肝臓外科における意義と展望2016

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Kuno Atsushi 久野敦

KUNO Atsushi 久野敦

久野敦クノアツシ