Mizuguchi Hiroyuki 水口裕之

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MIZUGUCHI Hiroyuki 水口裕之

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Researcher Number	50311387
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Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 教授 2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所肝細胞分化誘導プロジェクト, 招へいプロジェクトリーダー
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪大学, 大学院薬学研究科, 教授 2015 – 2021: 大阪大学, 薬学研究科, 教授 2017: 大阪大学, 大学院薬学研究科, 教授 2012 – 2015: 大阪大学, 薬学研究科(研究院), 教授 2012: 大阪大学, 大学院・薬学研究科, 教授 … More 2009 – 2012: Osaka University, 薬学研究科, 教授 2007: National Institute of Biomedical Innovation, 基盤的研究部・遺伝子導入制御プロジェクト, プロジェクトリーダー 2007: National Institute of Biomedical Innovation, 基盤的研究部・遺伝子導入制御プロジェクト, プロジェクトリーダー 2005 – 2007: 独立行政法人医薬基盤研究所, 基盤研究部・遺伝子導入制御プロジェクト, プロジェクトリーダー 2004: 国立医薬品食品衛生研究所, 基盤研究第3プロジェクトチーム, 副プロジェクト長 2004: 国立医薬品食品衛生研究所, 基盤研究第三プロジェクトチーム, 副プロジェクト長 2002 – 2003: 国立医薬品食品衛生研究所, 遺伝子細胞医薬部, 主任研究官 2001 – 2003: 国立医薬品食品衛生研究所, 研究員 1999 – 2001: 国立医薬品食品衛生研究所, 生物薬品部, 研究員 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Medical pharmacy / Biological Sciences / Medium-sized Section 90:Biomedical engineering and related fields / Medium-sized Section 47:Pharmaceutical sciences and related fields / Biomedical engineering/Biomaterial science and engineering / 医薬分子機能学 Except Principal Investigator Biomedical engineering/Biological material science / Basic Section 55060:Emergency medicine-related / Basic Section 90120:Biomaterials-related … More / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Applied pharmacology / General surgery / 応用薬理学・医療系薬学 / Biological pharmacy / Thoracic surgery / Medical pharmacy Less
Keywords	Principal Investigator 遺伝子治療 / 癌 / アデノウイルスベクター / バイオテクノロジー / 免疫学 / 遺伝子 / ウイルス / ターゲティング / ファイバー / iPS細胞 … More / mirtron / サイトカイン / 受容体 / CD46 / ターゲッティング / 腸管 / 肝臓 / オルガノイド / ゲノム編集 / 創薬 / 分化 / ヒト小腸吸収上皮細胞 / ヒト小腸オルガノイド / nonhuman primates / gene therapy / adenovirus vector / 霊長類 / セロトニン / 交感神経 / ストレス / セロトニン神経 / microRNA / 癌治療 / 抗体 / 遺伝子発現 / ファージライブラリ / ポリエチレングリコール / ファージ表面提示法 / 一本鎖抗体 / miRNA / 分子生物学 / 妊娠機能 / 骨量 / アドレナリン / ドーパミン / ノックアウトマウス / マイクロRNA / 間葉系幹細胞 / アデノウィルスベクター / DDS / 細胞治療 / 間葉系肝細胞 / CAR / アデノウイルス / 造血幹細胞 / ターゲッテイング / EBウイルス … More Except Principal Investigator 組織工学 / 遺伝子治療 / 再生医療 / 腫瘍溶解性ウイルス / アデノウイルス / アデノウイルスベクター / 腸管免疫 / 難治性下痢症 / 便移植 / 腸内細菌叢 / メタゲノム / 糞便微生物移植 / IgA / dysbiosis / 腸 / 全身性炎症反応 / Dysbiosis / 腸管 / ICU / 救急 / 腸内細菌 / ケモカイン / エクソソーム / 腫瘍内浸潤 / がん / ウイルス / 自然免疫 / 細胞障害性T細胞 / レオウイルス / 抗腫瘍免疫 / 細胞外小胞 / がん微小環境 / 臓器不全 / 幹細胞 / 胆管上皮細胞 / 細胞外マトリックス / 肝臓移植 / 胆管再生 / 臓器再生 / 脱細胞化 / プロセシング / microRNA / 癌 / 腫瘍溶解性アデノウイルス / Dicer / 非コードRNA / 細胞移植 / 血液凝固因子 / 細胞遺伝子治療 / 血友病 / 薬物代謝 / iPS細胞 / 肝細胞 / 細胞療法 / 人工臓器学 / quantification / transcriptional efficiency / adeno-virus / endocytosis / intracellular trafficking / 体内動態制御 / 細胞内動態制御 / ウイルスベクター / 非ウイルスベクター / ライソゾーム / エンドソーム / 共焦点レーザー顕微鏡 / 定量的評価 / 転写効率 / エンドサイトーシス / 細胞内動態 / plasmid vector / gene requlation / adeno-associated virus vector / adenovirus vector / gene therapy / プラスミドベクター / 発現調節能 / アデノ随伴ウイルス / cross clamping法 / 定常流ポンプ / 左心補助循環 / SERCA2a / 遺伝子デリバリー法 / カチオン性合成ベクター / 重症不全心 / 遺伝子導入 / 心筋再生療法 / 心臓大血管外科学 / 免疫隔離 / 細胞表面修飾 / 細胞治療 / 細胞・組織工学 / 種差 / 内分泌撹乱作用 / 発生毒性 / 胎盤 Less

Development of recombinant adenovirus medicinesPrincipal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Osaka University
A novel analysis of gut barrier function and immunity via gut microbiota and the establishment of fecal microbiota transplantation in critically illnessess
- Principal Investigator
  
  清水健太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Osaka University
ゲノム編集とiPS細胞やオルガノイド培養技術を用いたヒトモデル表現型解析系の開発Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Elucidation of oncolytic virus-mediated intratumorl infiltration of immune cells and development of further promotion methods
- Principal Investigator
  
  櫻井文教
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Osaka University
Development of novel recombinant adenovirusesPrincipal Investigator
- Principal Investigator
  
  Mizuguchi Hiroyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Osaka University
Bile Duct Regeneration for Transplantable Functional Liver Graft
- Principal Investigator
  
  Yagi Hiroshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Keio University
Development of human biopsy-derived intestinal organoids monolayers and application for pharmaceutical researchPrincipal Investigator
- Principal Investigator
  
  Mizuguchi Hiroyuki
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Development of novel adenovirus vectors through the analysis of the virus with mammalian cellsPrincipal Investigator
- Principal Investigator
  
  Hiroyuki Mizuguchi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
The development of novel adenovirus vectors and application for treatment, prevention, and diagnosis of diseasesPrincipal Investigator
- Principal Investigator
  
  Mizuguchi Hiroyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Osaka University
Creation of iPS-derived Hepatocyte-based Therapeutic Modality Using Liver Micro-organoids
- Principal Investigator
  
  OHASHI KAZUO
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Osaka University
Development of a novel oncolytic virus by regulating the processing of virus-derived non-coding RNA
- Principal Investigator
  
  SAKURAI FUMINORI
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Osaka University
Regulation of mammalian neuronal system by a novel microRNA "mirtron".Principal Investigator
- Principal Investigator
  
  MIZUGUCHI Hiroyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
Cell-based Therapies Toward Hemophilia Using Autologous Cells from Hemophilic Individuals
- Principal Investigator
  
  OHASHI KAZUO
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Osaka University
  Nara Medical University
  Tokyo Women's Medical University
The development of the novel targeted adenovirus vectorsPrincipal Investigator
- Principal Investigator
  
  MIZUGUCHI Hiroyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University
Development of liver-target therapy based on cellular modification technology
- Principal Investigator
  
  OHASHI Ohashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University
Development of hybrid therapy of myocardial regenerative medicine and ventricular assist circulation to improve prognosis of heart transplant candidate
- Principal Investigator
  
  TAKEWA Yoshiaki
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  National Cardiovascular Center Research Institute
新規small RNA分子mirtronの生理的機能の解明Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Osaka University
遺伝子改変間葉系幹細胞を用いたがんに対する新しい細胞治療戦略Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Biomedical Innovation
アデノウイルス受容体CARと相同性を有する可溶性新規タンパク質sCARの機能解析Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  独立行政法人医薬基盤研究所
Research of gene transfer into nonhuman promates using novel types of adenovirus vectorsPrincipal Investigator
- Principal Investigator
  
  MIZUGUCHI Hiroyuki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Biomedical Innovation
改変型アデノウイルスベクターを用いたin vivo胎盤毒性評価系の構築
- Principal Investigator
  
  中西剛
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Medical pharmacy
- Research Institution
  Osaka University
癌への特異的標的化を可能とするアデノウイルスベクターシステムの開発Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Health Sciences
35型アデノウイルスベクターシステムの開発Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Medical pharmacy
- Research Institution
  National Institute of Health Sciences
Optimization of pharmacokinetics and intracellular pharmacokinetics of viral and non-viral gene delivery system
- Principal Investigator
  
  HARASHIMA Hideyoshi
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  HOKKAIDO UNIVERSITY
ターゲッティング能を有したアデノウイルスベクターシステムの開発Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Health Sciences
Development of stable and regulated gene expression system for gene therapy
- Principal Investigator
  
  HAYAKAWA Takao
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
安全で高効率長期遺伝子発現を可能とするアデノーEBハイブリッドベクターの開発Principal Investigator
- Principal Investigator
  
  水口裕之
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  National Institute of Health Sciences

[Book] バイオロジクスの開発と品質・安全性確保　下巻 (担当:分担執筆, 範囲:第2章第1節　アデノウイルスベクター)2018
- Author(s)
  水口裕之・早川堯夫
- Total Pages
  504
- Publisher
  エル・アイ・シー出版
- ISBN
  9784900487574
- Data Source
  KAKENHI-PROJECT-17H00863
[Book] ドラッグデリバリーシステム-バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発- (担当:分担執筆, 範囲:第22 章　粘膜免疫誘導型ワクチンとしてのアデノウイルスベクター)2018
- Author(s)
  立花雅史、邊見昌久、水口裕之
- Total Pages
  260
- Publisher
  CMC出版
- ISBN
  9784781313337
- Data Source
  KAKENHI-PROJECT-17H00863
[Journal Article] Establishment of human intestinal organoids derived from commercially available cryopreserved intestinal epithelium and evaluation for pharmacokinetic study.2024
- Author(s)
  Okada K., Yokota J., Yamashita T., Inui T., Kishimoto W., Nakase H., Mizuguchi H.
- Journal Title
  
  Drug. Metab. Pharmacokinet.
  
  Volume: 54 Pages: 100532-100532
- DOI
  10.1016/j.dmpk.2023.100532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18247
[Journal Article] Functional intestinal monolayers from organoids derived from human iPS cells for drug discovery research.2024
- Author(s)
  Inui T., Uraya Y., Yokota J., Yamashita T., Kawai K., Okada K., Ueyama-Toba Y., Mizuguchi H.
- Journal Title
  
  Stem Cell Res. Ther.
  
  Volume: 15 Issue: 1 Pages: 57-57
- DOI
  10.1186/s13287-024-03685-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18247
[Journal Article] Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids established from a single individual.2023
- Author(s)
  Inui T., Yamashita T., Tomita J., Yokota J., Kishimoto W., Nakase H., Mizuguchi H.
- Journal Title
  
  Drug. Metab. Pharmacokinet.
  
  Volume: 48 Pages: 100482-100482
- DOI
  10.1016/j.dmpk.2022.100482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18247
[Journal Article] Treatment of human pancreatic cancers following local and systemic administration of oncolytic adenovirus serotype 35.2023
- Author(s)
  Ono R., Takayama K., Onishi R., Tokuoka S., Sakurai F., Mizuguchi H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 43 Issue: 2 Pages: 537-546
- DOI
  10.21873/anticanres.16190
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00664, KAKENHI-PROJECT-22KJ2163
[Journal Article] Biliary epithelial cell differentiation of bipotent human liver-derived organoids by 2D and 3D culture.2023
- Author(s)
  Tong Y., Ueyama-Toba Y., Mizuguchi H.
- Journal Title
  
  Biochem. Biophys. Rep.
  
  Volume: 33 Pages: 101432-101432
- DOI
  10.1016/j.bbrep.2023.101432
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18247
[Journal Article] 腫瘍溶解性ウイルスによる抗腫瘍免疫の活性化とがん免疫療法との併用2023
- Author(s)
  櫻井文教、水口裕之
- Journal Title
  
  ドラックデリバリーシステム
  
  Volume: 38 Pages: 24-30
- Data Source
  KAKENHI-PROJECT-20H00664
[Journal Article] Pre-treatment of oncolytic reovirus improves tumor accumulation and intratumoral distribution of PEG-liposomes2023
- Author(s)
  Eguchi Maho、Hirata Seiya、Ishigami Ikuho、Shuwari Naomi、Ono Ryosuke、Tachibana Masashi、Tanuma Masato、Kasai Atsushi、Hashimoto Hitoshi、Ogawara Ken-ichi、Mizuguchi Hiroyuki、Sakurai Fuminori
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 354 Pages: 35-44
- DOI
  10.1016/j.jconrel.2022.12.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19483, KAKENHI-PROJECT-20H00492, KAKENHI-PROJECT-21H03817
[Journal Article] 新規アデノウイルス製剤　～非増殖型ベクターと腫瘍溶解性ウイルス～2023
- Author(s)
  水口裕之
- Journal Title
  
  医学のあゆみ
  
  Volume: -
- Data Source
  KAKENHI-PROJECT-20H00664
[Journal Article] Establishment of UGT1A1-knockout human iPS-derived hepatic organoids for UGT1A1-specific kinetics and toxicity evaluation.2023
- Author(s)
  Shintani T., Imamura C., Ueyama-Toba Y., Inui J., Watanabe A., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Methods. Clin. Dev.
  
  Volume: 30 Pages: 429-442
- DOI
  10.1016/j.omtm.2023.08.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18247
[Journal Article] Establishment of MDR1-knockout human enteroids for pharmaceutical application.2023
- Author(s)
  Inui T., Nomoto R., Yokota J., Yamashita T., Okada K., Kishimoto W., Nakase H., Mizuguchi H.
- Journal Title
  
  Drug. Metab. Pharmacokinet.
  
  Volume: 48 Pages: 100476-100476
- DOI
  10.1016/j.dmpk.2022.100476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18247
[Journal Article] Effects of pre-existing anti-adenovirus antibodies on transgene expression levels and therapeutic efficacies of arming oncolytic adenovirus.2022
- Author(s)
  Ono R., Nishimae F., Wakida T., Sakurai F., Mizuguchi H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 12 Issue: 1 Pages: 21560-21560
- DOI
  10.1038/s41598-022-26030-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00664, KAKENHI-PROJECT-21H03817, KAKENHI-PROJECT-22KJ2163
[Journal Article] A dopamine antagonist, domperidone, enhances the replication of an oncolytic adenovirus in human tumor cells.2022
- Author(s)
  Nishimae F., Sakurai F., Ono R., Onishi R., Takayama K., Mizuguchi H.
- Journal Title
  
  J. Gen. Virol.
  
  Volume: 103 Issue: 6 Pages: 001752-001752
- DOI
  10.1099/jgv.0.001752
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00664, KAKENHI-PROJECT-21H03817
[Journal Article] Adenovirus vector-based vaccine for infectious diseases.2022
- Author(s)
  Sakurai F., Tachibana M., Mizuguchi H.
- Journal Title
  
  Drug Metab. Pharmacokinet.
  
  Volume: 42 Pages: 100432-100432
- DOI
  10.1016/j.dmpk.2021.100432
- NAID
  210000173033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00664, KAKENHI-PROJECT-21H03817
[Journal Article] Adenovirus Vector With ADP Gene Induces Cytopathic Effects in HEK293 Cells Without Significant Elevation of Virus Titers.2022
- Author(s)
  Shiota A, Nishimae F, Sakurai F, Mizuguchi H.
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 4 Pages: 1719-1727
- DOI
  10.21873/anticanres.15648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H03817
[Journal Article] Tumor‐targeted fluorescence labeling systems for cancer diagnosis and treatment2022
- Author(s)
  Tazawa H、Shigeyasu K、Noma K、Kagawa S、Sakurai F、Mizuguchi H、Kobayashi H、Imamura T、Fujiwara T
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 6 Pages: 1919-1929
- DOI
  10.1111/cas.15369
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07219, KAKENHI-PROJECT-21H03056, KAKENHI-PROJECT-23K24407, KAKENHI-PROJECT-21H03817
[Journal Article] アデノウイルスベクターワクチンの現状と展望2022
- Author(s)
  水口裕之
- Journal Title
  
  ドラックデリバリーシステム
  
  Volume: 37 Pages: 421-428
- Data Source
  KAKENHI-PROJECT-20H00664
[Journal Article] Liver-specific overexpression of lipoprotein lipase improves glucose metabolism in high-fat diet-fed mice2022
- Author(s)
  Shimizu Kahori、Nishimuta Syogo、Fukumura Yuri、Michinaga Shotaro、Egusa Yuka、Hase Tomomi、Terada Tomoyuki、Sakurai Fuminori、Mizuguchi Hiroyuki、Tomita Koji、Nishinaka Toru
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 9 Pages: e0274297-e0274297
- DOI
  10.1371/journal.pone.0274297
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06680, KAKENHI-PROJECT-21H03817
[Journal Article] アデノウイルスベクターワクチン設計のサイエンス　～COVID-19に対するワクチン開発を中心に～2022
- Author(s)
  水口裕之
- Journal Title
  
  別冊・医学のあゆみ
  
  Volume: ー Pages: 83-88
- Data Source
  KAKENHI-PROJECT-20H00664
[Journal Article] Fiber-Knob Region of Adenovirus Type 5 Vector Promotes Migration of A549 Cells2021
- Author(s)
  Kano Junpei、Koizumi Naoya、Terada Airi、Matsuoka Ayana、Hirai Takamasa、Nomura Tetsuya、Mizuguchi Hiroyuki、Utoguchi Naoki
- Journal Title
  
  BPB Reports
  
  Volume: 4 Issue: 1 Pages: 17-21
- DOI
  10.1248/bpbreports.4.1_17
- NAID
  130007980821
- ISSN
  2434-432X
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07685, KAKENHI-PROJECT-20H00664
[Journal Article] Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 352021
- Author(s)
  Ono Ryosuke、Takayama Kosuke、Sakurai Fuminori、Mizuguchi Hiroyuki
- Journal Title
  
  Molecular Therapy - Oncolytics
  
  Volume: 20 Pages: 399-409
- DOI
  10.1016/j.omto.2021.01.015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04101, KAKENHI-PROJECT-20H00664
[Journal Article] Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research.2021
- Author(s)
  Yamashita T., Inui T., Yokota J., Kawakami K., Morinaga G., Takatani M., Hirayama D., Nomoto R., Ito K., Cui Y., Ruez S., Harada K., Kishimoto W., Nakase H., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Methods. Clin. Dev.
  
  Volume: 22 Pages: 263-278
- DOI
  10.1016/j.omtm.2021.05.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20381, KAKENHI-PROJECT-19J21382, KAKENHI-PROJECT-21K18247
[Journal Article] Optimization of an E1A Gene Expression Cassette in an Oncolytic Adenovirus for Efficient Tumor Cell Killing Activity2021
- Author(s)
  SAKURAI FUMINORI、NISHIMAE FUMITAKA、TAKAYAMA KOSUKE、MIZUGUCHI HIROYUKI
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 2 Pages: 773-782
- DOI
  10.21873/anticanres.14829
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04101, KAKENHI-PROJECT-20H00664
[Journal Article] The infectivity of progeny adenovirus in the presence of neutralizing antibody2021
- Author(s)
  Hirai Takamasa、Sato Anna、Koizumi Naoya、Kurioka Yoh、Suzuki Yui、Kano Junpei、Yamakawa Makie、Nomura Tetsuya、Fujii Makiko、Sakurai Fuminori、Mizuguchi Hiroyuki、Watanabe Yoshiteru、Utoguchi Naoki
- Journal Title
  
  Journal of General Virology
  
  Volume: 102 Issue: 4 Pages: 1-10
- DOI
  10.1099/jgv.0.001590
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07685, KAKENHI-PROJECT-20H00664
[Journal Article] A TGFβ Signaling Inhibitor, SB431542, Inhibits Reovirus-mediated Lysis of Human Hepatocellular Carcinoma Cells in a TGFβ-independent Manner2021
- Author(s)
  ISHIGAMI IKUHO、SHUWARI NAOMI、KAMINADE TADATAKA、MIZUGUCHI HIROYUKI、SAKURAI FUMINORI
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 5 Pages: 2431-2440
- DOI
  10.21873/anticanres.15018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03817
[Journal Article] アデノウイルスベクターワクチン設計のサイエンス　～COVID-19に対するワクチン開発を中心に～2021
- Author(s)
  水口裕之
- Journal Title
  
  医学のあゆみ
  
  Volume: 279 Pages: 999-1004
- Data Source
  KAKENHI-PROJECT-20H00664
[Journal Article] Oncolytic reovirus-mediated killing of mouse cancer-associated fibroblasts2021
- Author(s)
  Kurisu Nozomi、Kaminade Tadataka、Eguchi Maho、Ishigami Ikuho、Mizuguchi Hiroyuki、Sakurai Fuminori
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 610 Pages: 121269-121269
- DOI
  10.1016/j.ijpharm.2021.121269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03817
[Journal Article] Vinblastine treatment enhances the intestinal functions and decreases the undifferentiated cell contamination of human iPS cell-derived intestinal epithelial-like cells.2021
- Author(s)
  Ichikawa M., Negoro R., Kawai K., Yamashita T., Takayama K., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Methods. Clin. Dev.
  
  Volume: 20 Pages: 463-472
- DOI
  10.1016/j.omtm.2021.01.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20381
[Journal Article] Transduction Properties of an Adenovirus Vector Containing Sequences Complementary to a Liver-Specific microRNA, miR-122a, in the 3′-Untranslated Region of the E4 Gene in Human Hepatocytes from Chimeric Mice with Humanized Liver2021
- Author(s)
  Sakurai Fuminori, Tsukamoto Tomohito, Ono Ryosuke, Nishimae Fumitaka, Shiota Aoi, Iizuka Shunsuke, Shimizu Kahori, Sakai Eiko, Ishida Yuji, Tateno Chise, Chayama Kazuaki, Mizuguchi Hiroyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 10 Pages: 1506-1513
- DOI
  10.1248/bpb.b21-00394
- NAID
  130008095771
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06680, KAKENHI-PROJECT-20H00664, KAKENHI-PROJECT-21H03817
[Journal Article] Comparison of culture media for human intestinal organoids from the viewpoint of pharmacokinetic studies.2021
- Author(s)
  Yokota J., Yamashita T., Inui T., Nomoto R., Kishimoto W., Nakase H., Mizuguchi H.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 566 Pages: 115-122
- DOI
  10.1016/j.bbrc.2021.06.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20381, KAKENHI-PROJECT-19J21382
[Journal Article] In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics.2021
- Author(s)
  Takayama K., Ito K., Matsui A., Yamashita T., Kawakami K., Hirayama D., Kishimoto W., Nakase H., Mizuguchi H.
- Journal Title
  
  Drug. Metab. Dispos.
  
  Volume: 49 Issue: 3 Pages: 221-232
- DOI
  10.1124/dmd.120.000283
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20381, KAKENHI-PROJECT-18H02799
[Journal Article] A selective cytotoxic adenovirus vector for concentration of pluripotent stem cells in human pluripotent stem cell-derived neural progenitor cells.2021
- Author(s)
  Hirai T., Kono K., Sawada R., Kuroda T., Yasuda S., Matsuyama S., Matsuyama A., Koizumi N., Utoguchi N., Mizuguchi H., Sato Y.
- Journal Title
  
  Sci. Rep.
  
  Volume: 11 Issue: 1 Pages: 11407-11407
- DOI
  10.1038/s41598-021-90928-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00664
[Journal Article] Establishment of MDR1-knockout human induced pluripotent stem cell line.2020
- Author(s)
  2)Negoro R., Kawai K., Ichikawa M., Deguchi S., Takayama K., Mizuguchi H.
- Journal Title
  
  Drug. Metab. Pharmacokinet.
  
  Volume: in press Issue: 3 Pages: 288-296
- DOI
  10.1016/j.dmpk.2020.01.009
- NAID
  50014558599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20381
[Journal Article] Photoactivatable oncolytic adenovirus for optogenetic cancer therapy.2020
- Author(s)
  Hagihara Y., Sakamoto A., Tokuda T., Yamashita T., Ikemoto S., Kimura A., Haruta M., Sasagawa K., Ohta J., Takayama K., Mizuguchi H.
- Journal Title
  
  Cell Death Dis.
  
  Volume: 11 Issue: 7 Pages: 570-570
- DOI
  10.1038/s41419-020-02782-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00664
[Journal Article] Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody.2020
- Author(s)
  Kanaya N., Kuroda S., Kakiuchi Y., Kumon K., Tsumura T., Hashimoto M., Morihiro T., Kubota T., Aoyama K., Kikuchi S., Nishizaki M., Kagawa S., Tazawa H., Mizuguchi H., Urata Y., Fujiwara T.
- Journal Title
  
  Mol. Ther.
  
  Volume: 28 Issue: 3 Pages: 794-804
- DOI
  10.1016/j.ymthe.2020.01.003
- NAID
  120006952300
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-20H00664
[Journal Article] Development of a novel oncolytic adenovirus expressing a short-hairpin RNA against Cullin 4A.2020
- Author(s)
  Wakabayashi K., Sakurai F., Ono R., Fujiwara T., Mizuguchi H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 40 Issue: 1 Pages: 161-168
- DOI
  10.21873/anticanres.13937
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00863
[Journal Article] Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer.2020
- Author(s)
  Koujima T., Tazawa H., Ieda T., Araki H., Fushimi T., Shoji R., Kuroda S., Kikuchi S., Yoshida R., Umeda Y., Teraishi F., Urata Y., Mizuguchi H., Fujiwara T.
- Journal Title
  
  Mol. Ther. Oncolysis.
  
  Volume: 17 Pages: 107-117
- DOI
  10.1016/j.omto.2020.03.016
- NAID
  120006869596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-19K09217, KAKENHI-PROJECT-19H03731, KAKENHI-PROJECT-20H00664
[Journal Article] Adenovirus Vector?Induced IL-6 Promotes Leaky Adenoviral Gene Expression, Leading to Acute Hepatotoxicity2020
- Author(s)
  Shimizu Kahori、Sakurai Fuminori、Iizuka Shunsuke、Ono Ryosuke、Tsukamoto Tomohito、Nishimae Fumitaka、Nakamura Shin-ichiro、Nishinaka Toru、Terada Tomoyuki、Fujio Yasushi、Mizuguchi Hiroyuki
- Journal Title
  
  The Journal of Immunology
  
  Volume: 206 Issue: 2 Pages: 410-421
- DOI
  10.4049/jimmunol.2000830
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21575, KAKENHI-PROJECT-17H04101, KAKENHI-PROJECT-18H02603, KAKENHI-PROJECT-18K14964, KAKENHI-PROJECT-20H00664
[Journal Article] Establishment of SLC15A1/PEPT1-knockout human induced pluripotent stem cell line for intestinal drug absorption studies2019
- Author(s)
  Kawai K., Negoro R., Ichikawa M., Yamashita T., Deguchi S., Harada K., Hirata K., Takayama K., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Methods. Clin. Dev.
  
  Volume: 17 Pages: 49-57
- DOI
  10.1016/j.omtm.2019.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20381
[Journal Article] Adenovirus Fiber can Distribute Itself to the Cell Surface without Membrane Damage.2019
- Author(s)
  Sato A., Hirai T., Koizumi N., Hatakeyama S., Watanabe A., Nomura T., Sakurai F., Mizuguchi H., Utoguchi N.
- Journal Title
  
  BPB Reports
  
  Volume: 2 Pages: 113-118
- NAID
  130007940517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00863
[Journal Article] A MicroRNA Derived from Adenovirus Virus-Associated RNAII Promotes Virus Infection via Posttranscriptional Gene Silencing.2019
- Author(s)
  Wakabayashi K., Machitani M., Tachibana M., Sakurai F., Mizuguchi H.
- Journal Title
  
  J. Virol.
  
  Volume: 93 Issue: 2
- DOI
  10.1128/jvi.01265-18
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-17H04101
[Journal Article] Efficient generation of adenovirus vectors carrying the Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR associated proteins (Cas)12a system by suppressing Cas12a expression in packaging cells.2019
- Author(s)
  Tsukamoto T., Sakai E., Nishimae F., Sakurai F., Mizuguchi H.
- Journal Title
  
  J. Biotech.
  
  Volume: 304 Pages: 1-9
- DOI
  10.1016/j.jbiotec.2019.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H00863
[Journal Article] Clinical features of squamous cell lung cancer with anaplastic lymphoma kinase (ALK)-rearrangement: a retrospective analysis and review.2018
- Author(s)
  Watanabe J, Togo S, Sumiyoshi I, Namba Y, Suina K, Mizuno T, Kadoya K, Motomura H, Iwai M, Nagaoka T, Sasaki S, Hayashi T, Uekusa T, Abe K, Urata Y, Sakurai F, Mizuguchi H, Kato S, Takahashi K.
- Journal Title
  
  Oncotarget
  
  Volume: 9(35) Issue: 35 Pages: 24000-24013
- DOI
  10.18632/oncotarget.25257
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08798, KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-18J14396
[Journal Article] Generation of the Adenovirus Vector-Mediated CRISPR/Cpf1 System and the Application for Primary Human Hepatocytes Prepared from Humanized Mice with Chimeric Liver2018
- Author(s)
  Tsukamoto T., Sakai E., Iizuka S., Taracena-Gandar M., Sakurai F., Mizuguchi H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 7 Pages: 1089-1095
- DOI
  10.1248/bpb.b18-00222
- NAID
  130007387204
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-07-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-16J04751
[Journal Article] A Flow Cytometry-Based Method to Determine the Titer of Adenoviruses Expressing an Extraneous Gene2018
- Author(s)
  Asada A., Hayakawa H., Yanase N., Abe K., Sakurai F., Mizuguchi H., Urata Y.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 41 Issue: 10 Pages: 1615-1619
- DOI
  10.1248/bpb.b18-00316
- NAID
  130007492909
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2018-10-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863
[Journal Article] Antibodies against adenovirus fiber and penton base proteins inhibit adenovirus vector-mediated transduction in the liver following systemic administration.2018
- Author(s)
  Tomita K., Sakurai F., Iizuka S., Hemmi M., Wakabayashi K., Tachibana M., Katayama K., Kamada H., Mizuguchi H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 12315-12315
- DOI
  10.1038/s41598-018-30947-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-16J04751, KAKENHI-PROJECT-17H04101
[Journal Article] Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies2018
- Author(s)
  Negoro Ryosuke、Takayama Kazuo、Kawai Kanae、Harada Kazuo、Sakurai Fuminori、Hirata Kazumasa、Mizuguchi Hiroyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 11 Issue: 6 Pages: 1539-1550
- DOI
  10.1016/j.stemcr.2018.10.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05033, KAKENHI-PROJECT-20K20381
[Journal Article] Suppression of oncolytic adenovirus-mediated hepatotoxicity by liver-specific inhibition of NF-κB.2017
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Tachibana M.,　Kato N., Fujiwara T., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Oncolysis.
  
  Volume: 7 Pages: 76-85
- DOI
  10.1016/j.omto.2017.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-16H05196, KAKENHI-PROJECT-16J05920
[Journal Article] Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression2017
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Nakatani K., Takayama K., Tachibana M., Mizuguchi H.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 3 Pages: 272-277
- DOI
  10.1248/bpb.b16-00700
- NAID
  130005398474
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-17H00863
[Journal Article] Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing sustained transgene expression via a reduction in the leaky expression of viral genes.2017
- Author(s)
  Iizuka S., Sakurai F., Tachibana M., Ohashi K., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Methods. Clin. Dev.
  
  Volume: 6 Pages: 183-193
- DOI
  10.1016/j.omtm.2017.07.001
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-16J04751
[Journal Article] Detection of circulating tumor cells in cervical cancer using a conditionally2017
- Author(s)
  Takakura M, Matsumoto T, Nakamura M, Mizumoto Y, Myojyo S, Yamazaki R, Iwadare
- Journal Title
  
  Cancer Sci.ence
  
  Volume: 109(1) Issue: 1 Pages: 231-240
- DOI
  10.1111/cas.13449
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11223, KAKENHI-PROJECT-17K11270, KAKENHI-PROJECT-15K10708, KAKENHI-PROJECT-18K09229, KAKENHI-PROJECT-17H00863
[Journal Article] MicroRNA miR-27 Inhibits Adenovirus Infection by Suppressing the Expression of SNAP25 and TXN2.2017
- Author(s)
  Machitani M, Sakurai F, Wakabayashi K, Nakatani K, Tachibana M, Mizuguchi H
- Journal Title
  
  Journalof Virology
  
  Volume: 印刷中 Issue: 12
- DOI
  10.1128/jvi.00159-17
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-17H00863
[Journal Article] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA.2017
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Takayama K., Tachibana M., Mizuguchi H.
- Journal Title
  
  Mol. Ther. Nucleic Acids,
  
  Volume: 6 Pages: 173-182
- DOI
  10.1016/j.omtn.2016.12.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-26293118, KAKENHI-PROJECT-17H04101
[Journal Article] Th17 Promotes Induction of antigen-specific gut-mucosal CTLs following adenovirus vector vaccination.2017
- Author(s)
  Hemmi M., Tachibana M.,, Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K.J., Akira S., Mizuguchi H.
- Journal Title
  
  Front Immunol.
  
  Volume: 8 Pages: 1456-1456
- DOI
  10.3389/fimmu.2017.01456
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H00863, KAKENHI-PROJECT-15J05681, KAKENHI-PROJECT-16K18873
[Journal Article] Enhanced oncolytic activities of the telomerase-specific replication-competent adenovirus expressing short-hairpin RNA against Dicer2017
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Tachibana M., Fujiwara T., Mizuguchi H.
- Journal Title
  
  Mol. Cancer Ther
  
  Volume: 16 Issue: 1 Pages: 251-259
- DOI
  10.1158/1535-7163.mct-16-0383
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118
[Journal Article] Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure.2016
- Author(s)
  Nagamoto Y., Takayama K., Ohashi K., Okamoto R., Sakurai F., Tachibana M., Kawabata K., Mizuguchi H.
- Journal Title
  
  Jpurnal of Hepatology
  
  Volume: 64 Issue: 5 Pages: 1068-1075
- DOI
  10.1016/j.jhep.2016.01.004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J02987, KAKENHI-PROJECT-26670587, KAKENHI-PROJECT-24300174, KAKENHI-PROJECT-16K01355
[Journal Article] TANK-binding kinase 1-dependent or -independent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector.2016
- Author(s)
  Tsuzuki S, Tachibana M, Hemmi M, Yamaguchi T, Shoji M, Sakurai F, Kobiyama K, Kawabata K, Ishii KJ, Akira S, Mizuguchi H.
- Journal Title
  
  Int Immunol.
  
  Volume: 28 Issue: 3 Pages: 105-115
- DOI
  10.1093/intimm/dxv058
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-15J05681
[Journal Article] Dicer functions as an antiviral system against human adenoviruses via cleavage of adenovirus-encoded noncoding RNA.2016
- Author(s)
  Machitani M, Sakurai F, Wakabayashi K, Tomita K, Tachibana M, Mizuguchi H
- Journal Title
  
  Scientific Reports
  
  Volume: - Issue: 1 Pages: 27598-27598
- DOI
  10.1038/srep27598
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05920, KAKENHI-PROJECT-26293118
[Journal Article] Evaluation of transduction properties of an adenovirus vector in neonatal mice.2015
- Author(s)
  Iizuka S, Sakurai F, Shimizu K, Ohashi K, Nakamura S-I, Tachibana M, Mizuguchi H.
- Journal Title
  
  BioMed Research International
  
  Volume: 685374 Pages: 1-10
- DOI
  10.1155/2015/685374
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26670587
[Journal Article] Efficient Gene Transduction to Dispersed Islet Cells in Culture Using Fiber-modified Adenoviral Vectors2015
- Author(s)
  Hanayama H, Ohashi K, Utoh R, Shimizu H, Ise K, Sakurai F, Mizuguchi H, Tsuchiya H, Okano T, Gotoh M.
- Journal Title
  
  Cell Medicine
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670587
[Journal Article] Efficient gene transduction of dispersed islet cells in culture using fiber-modified adenoviral vectors.2015
- Author(s)
  Hanayama H, Ohashi K, Utoh R, Shimizu H, Ise K, Sakurai F, MIzuguchi H, Tsuchiya H, Okano T, Gotoh M.
- Journal Title
  
  Cell Medicine
  
  Volume: 8 Issue: 1-2 Pages: 31-38
- DOI
  10.3727/215517915x689083
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26670587
[Journal Article] Quantitative Analysis of Virus-associated RNAI Expression following Transduction with a Replication-incompetent Adenovirus Vector In Vitro and In Vivo.2015
- Author(s)
  Wakabayashi K., Machitani M., Shimizu K., Tachibana M., Sakurai F., Mizuguchi H.
- Journal Title
  
  J. Mol. Genet. Med.
  
  Volume: 9 Issue: 02 Pages: 169-169
- DOI
  10.4172/1747-0862.1000169
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048, KAKENHI-PROJECT-15H06363, KAKENHI-PROJECT-26293118
[Journal Article] The early activation of CD8+ T cells is dependent on type I IFN signaling following intramuscular vaccination of adenovirus vector.2014
- Author(s)
  Hemmi M, Tachibana M, Tsuzuki S, Shoji M, Sakurai F, Kawabata K, Kobiyama K, Ishii KJ, Akira S, Mizuguchi H.
- Journal Title
  
  BioMed Res. International
  
  Volume: - Pages: 158128-158128
- DOI
  10.1155/2014/158128
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26242048
[Journal Article] Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome2014
- Author(s)
  Sakurai F, Shimizu K, Tomita K, Nagamoto Y, Nakamura S, Katayama K, Tachibana M, Kawabata K, Mizuguchi H.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: 1 Pages: 14035-14035
- DOI
  10.1038/mtm.2014.35
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300155, KAKENHI-PROJECT-26242048
[Journal Article] A targeted adenovirus vector displaying a human fibronectin type III domain-based monobody in a fiber protein.2013
- Author(s)
  Matsui H, Sakurai F, Katayama K, Abe Y, Machitani M, Kurachi S, Tachibana M, Mizuguchi H.
- Journal Title
  
  Biomaterials
  
  Volume: 34 Pages: 4191-201
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa2012
- Author(s)
  Shoji M, Tachibana M, Katayama K, Tomita K, Tsuzuki S, Sakurai F, Kawabata K, Ishii KJ, Akira S, Mizuguchi H.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 425 Pages: 89-93
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] Intramuscular DNA immunization with in vivo electroporation induces antigen- specific cellular and humoral immune responses in both systemic and gut-mucosal compartments.2012
- Author(s)
  Shoji M, Katayama K, Tachibana M, Tomita K, Sakurai F, Kawabata K, Mizuguchi H
- Journal Title
  
  Vaccine.
  
  Volume: 30 Pages: 7278-85
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] Further reduction in adenovirus vector-mediated liver transduction without largely affecting transgene expression in target organ by exploiting microRNA-mediated regulation and the Cre-loxP recombination system2012
- Author(s)
  Bennett D, Sakurai F, Shimizu K, Matsui H, Tomita K, Suzuki T, Katayama K, Kawabata K, Mizuguchi H.
- Journal Title
  
  Mol. Pharmaceutics
  
  Volume: 9 Pages: 3452-3463
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] A hexon-specific PEGylated adenovirus vector utilizing blood coagulation factor X2012
- Author(s)
  Matsui H, Sakurai F, Katayama K, Yamaguchi T, Okamoto S, Takahira K, Tachibana M, Nakagawa S, Mizuguchi H.
- Journal Title
  
  Biomaterials.
  
  Volume: 33 Pages: 3743-55
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] Correlation between adenovirus-neutralizing antibody titer and adenovirus vector- mediated transduction efficiency following intratumoral injection2012
- Author(s)
  Tomita K., Sakurai F., Tachibana M., Mizuguchi H
- Journal Title
  
  Anticancer Res
  
  Volume: 32 Pages: 1145-1152
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] Efficient antitumor effects of carrier cells loaded with a fiber-substituted conditionally replicating adenovirus on CAR-negative tumor cells.2012
- Author(s)
  Iguchi K., Sakurai F., Tomita K., Katayama K., Yamaguchi T., Tagawa M., Kawabata M., Shirakawa T., Mizuguchi H.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: 19 Pages: 118-125
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] ウイルスベクターと遺伝子治療2011
- Author(s)
  水口裕之、櫻井文教
- Journal Title
  
  化学療法の領域
  
  Volume: 27 Pages: 867-873
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] Enhanced transduction efficiency of fiber-substituted adenovirus vectors by the incorporation of RGD peptides in two distinct regions of the adenovirus serotype 35 fiber knob.2011
- Author(s)
  Matsui H, Sakurai F, Katayama K, Kurachi S, Tashiro K, Sugio K, Kawabata K, Mizuguchi H
- Journal Title
  
  Virus Research
  
  Volume: 155 Pages: 48-54
- Data Source
  KAKENHI-PROJECT-22390030
[Journal Article] Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates.2008
- Author(s)
  Fuminori Sakurai, Shin-ichiro Nakamura, Kimiyo Akitomo, Hiroaki Shibata, Keiji Terao, Kenji Kawabata, Takao Hayakawa, Hiroyuki Mizuguchi
- Journal Title
  
  Molecular Therapy 16(4)
  
  Pages: 726-733
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] Transduction properties of adenovirus serotype 35 vectors after intravenous administration into nonhuman primates2008
- Author(s)
  Fuminori Sakurai, Shin-ichiro Nakamura, Kimiyo Akitomo, Hiroaki Shibata, Keiji Terao, Kenji Kawabata, Takao Hayakawa, Hiroyuki Mizuguchi.
- Journal Title
  
  Molecular Therapy 16(4)
  
  Pages: 726-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] 改良型アデノウイルヌベクターを用いた遺伝子デリバリー2007
- Author(s)
  川端健二・櫻井文教・水口裕之
- Journal Title
  
  Drug Delivery System 22(6)
  
  Pages: 668-669
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] アデノウイルスベクター開発の最前線2007
- Author(s)
  水口裕之
- Journal Title
  
  バイオテクノロジージャーナル 7(2)
  
  Pages: 168-173
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] Adenovirus vectors composed of subgroup B adenoviruses.2007
- Author(s)
  Fuminori Sakurai, Kenji Kawabata, Hiroyuki Mizuguchi.
- Journal Title
  
  Current Gene Therapy 7(4)
  
  Pages: 229-238
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] Fiber-modified adenovirus vectors containing the TAT peptide derived from human immunodeficiency virus in the fiber knob have efficient gene transfer activity.2007
- Author(s)
  Kurachi S., Tashiro K., Sakurai F., Sakurai H., Kawabata K., Yayama K., Okamoto H., Nakagawa S., Hayakawa T., Mizuguchi H.
- Journal Title
  
  Gene Ther. (in press)
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] 改良型アデノウイルスベクターを用いた遺伝子デリバリー2007
- Author(s)
  川端健二, 櫻井文教, 水口裕之
- Journal Title
  
  Drug Delivery System (in press)
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] アデノウイルスベクター開発の最前線2007
- Author(s)
  水口裕之
- Journal Title
  
  バイオテクノロジージャーナル 7(2)
  
  Pages: 168-173
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] Adenovirus vectors composed of subgroup B adenoviruses2007
- Author(s)
  Fuminori Sakurai, Kenji Kawabata, Hiroyuki Mizuguchi
- Journal Title
  
  Current Gene Therapy 7(4)
  
  Pages: 229-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] アデノウイルスペクター開発の最前線2007
- Author(s)
  水口裕之
- Journal Title
  
  バイオテクノロジージャーナル 7-2
  
  Pages: 168-173
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] カプシドタンパク質改変アデノウイルスべクター2007
- Author(s)
  水口裕之、櫻井文教、川端健二
- Journal Title
  
  遺伝子医学MOOK別冊絵で見てわかるナノDDS
  
  Pages: 235-242
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] Fiber-modified adenovirus vectors containing the TAT peptide derived from human immunodeficiency virus in the fiber knob have efficient gene:transfer activity2007
- Author(s)
  Kurachi S., Tashiro K., Sakurai F., Sakurai H., Kawabata K., Yayama K., Okamoto H., Nakagawa S., Hayakawa T., Mizuguchi H.
- Journal Title
  
  Gene Ther. 14
  
  Pages: 1160-1165
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] アデノウイルスベクター開発の最前線2007
- Author(s)
  水口裕之
- Journal Title
  
  バイオテクノロジージャーナル 7(2)
  
  Pages: 168-173
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] Characterization of adenovirus serotype 35 vectors using genetically modified animals and non-human primates2006
- Author(s)
  Fuminori Sakurai, Kenji Kawabata, Hiroyuki Mizuguchi
- Journal Title
  
  Yakugaku Zasshi 126(11)
  
  Pages: 1013-9
- NAID
  110004857367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] characterization of adenovirus serotype 35 vectors using genetically modified animals and non-human primates2006
- Author(s)
  Sakurai F, Kawabata K, Mizuguchi H
- Journal Title
  
  Yakugaku Zasshi 126-11
  
  Pages: 1013-9
- NAID
  110004857367
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] 新しいアデノウイルスペクターの開発2006
- Author(s)
  桜井文教, 水口裕之
- Journal Title
  
  バイオサイエンスとインダストリー 64-5
  
  Pages: 255-260
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] 新しいアデノウイルスベクターの開発2006
- Author(s)
  櫻井文教・水口裕之
- Journal Title
  
  バイオサイエンスとインダストリー 64(5)
  
  Pages: 255-260
- NAID
  10017483842
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] The short consensus repeats 1 and 2, not the cytoplasmic domain of human CD46 are crucial for infection of subgroup B adenovirus serotype 352006
- Author(s)
  Sakurai F, Murakami S, Kawabata K, Okada N, Yamamoto A, Seya T, Hayakawa T, Mizuguchi H
- Journal Title
  
  Journal of Controlled Release 113-2
  
  Pages: 271-278
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] Adenovirus vector-mediated gene transfer into stem cells.2006
- Author(s)
  Kawabata K., Sakurai F., Koizumi N., Hayakawa T., Mizuguchi H.
- Journal Title
  
  Mol. Pharmaceutics 3
  
  Pages: 95-103
- Data Source
  KAKENHI-PROJECT-18015054
[Journal Article] The short consensus repeats 1 and 2, not the cytoplasmic domain, of human CD46 are crucial for infection of subgroup B adenovirus serotype 35.2006
- Author(s)
  Fuminori Sakuiai, Sayaka Murakami, Kawabata K, Okada N, Yamamoto A, Seya T, Hayakawa, T, Mizuguchi H.
- Journal Title
  
  J. Control. Rel. 113(3)
  
  Pages: 271-278
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] Approaches to improve the kinetics of adenovirus delivered gene and gene product.2005
- Author(s)
  Xu Z.L., Mizuguchi H., Koizumi N., Sakurai F., Hosono T., Kawabata K., Watanabe Y., Yamaguchi T., Hayakawa T.
- Journal Title
  
  Adv.Drug.Deli.Rev. 57
  
  Pages: 781-802
- Data Source
  KAKENHI-PROJECT-17659023
[Journal Article] Approaches to improve the kinetics of adenovirus delivered gene and gene product.2005
- Author(s)
  Xu Z.L., Mizuguchi H., Koizumi N., Sakurai F., Hosono T., Kawabata K., Watanabe Y., Yamaguchi T., Hayakawa T.
- Journal Title
  
  Adv.Drug.Deli.Rev. 57
  
  Pages: 781-802
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] Adenovirus vector-mediated gene transfer into stem cells.2005
- Author(s)
  Kawabata K., Sakurai F., Koizumi N., Hayakawa T., Mizuguchi H.
- Journal Title
  
  Mol.Pharmaceutics 3
  
  Pages: 95-103
- Data Source
  KAKENHI-PROJECT-17659023
[Journal Article] Adenovirus vector-mediated gene transfer into stem cells.2005
- Author(s)
  Kawabata K., Sakurai F., Koizumi N., Hayakawa T., Mizuguchi H.
- Journal Title
  
  Mol.Pharmaceutics 3
  
  Pages: 95-103
- Data Source
  KAKENHI-PROJECT-17390047
[Journal Article] Targeted adenovirus vectors2004
- Author(s)
  Mizuguchi, H. et al.
- Journal Title
  
  Hum. Gene Ther. 15
  
  Pages: 1022-1033
- Data Source
  KAKENHI-PROJECT-13218142
[Journal Article] 改良型アデノウイルスベクターを用いた造血幹細胞、間葉系幹細胞、ES細胞への高効率遺伝子導入
- Author(s)
  水口裕之ら
- Journal Title
  
  炎症・再生(日本炎症・再生医学会学会誌) (印刷中)
- NAID
  10026499185
- Data Source
  KAKENHI-PROJECT-15689003
[Journal Article] カプシドタンパク質を改変した改良型アデノウイルスベクターによる高効率遺伝子導入
- Author(s)
  Mizuguchi, H. et al.
- Journal Title
  
  BIO INDUSTRY (印刷中)
- Data Source
  KAKENHI-PROJECT-15689003
[Journal Article] ウイルスベクターと遺伝子治療
- Author(s)
  水口裕之、櫻井文教
- Journal Title
  
  化学療法の領域
  
  Volume: (印刷中)
- Data Source
  KAKENHI-PROJECT-22390030
[Patent] ヘキソン改変型アデノウイルスベクター2022
- Inventor(s)
  水口裕之、櫻井文教、鎌田春彦
- Industrial Property Rights Holder
  水口裕之、櫻井文教、鎌田春彦
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-102883
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20H00664
[Patent] 腫瘍溶解性ヒト35型アデノウイルス2020
- Inventor(s)
  水口裕之、櫻井文教
- Industrial Property Rights Holder
  水口裕之、櫻井文教
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-17H00863
[Patent] 腸上皮様細胞及びその作製方法2020
- Inventor(s)
  水口裕之、高山和雄、山下智起、仲瀬裕志、川上賢太郎、平山大輔
- Industrial Property Rights Holder
  水口裕之、高山和雄、山下智起、仲瀬裕志、川上賢太郎、平山大輔
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-016592
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K20381
[Patent] 小腸上皮様細胞の製造方法2020
- Inventor(s)
  水口裕之、高山和雄、根来亮介、ほか
- Industrial Property Rights Holder
  国立大学法人大阪大学、医薬基盤・健康・栄養研究所、ほか
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20K20381
[Patent] 腫瘍溶解性ヒト35型アデノウイルス2019
- Inventor(s)
  水口裕之、櫻井文教
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-17H00863
[Patent] 新規アデノウイルス及びその増殖促進方法2014
- Inventor(s)
  水口裕之、櫻井文教、町谷充洋
- Industrial Property Rights Holder
  国立大学法人　大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2014-08-22
- Overseas
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] ヒト肝臓オルガノイドの創薬研究への応用2024
- Author(s)
  植山（鳥羽）由希子、仝嫣然、水口裕之、
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] オルガノイド培養技術により開発された高機能なヒトiPS細胞由来小腸上皮細胞の機能解析2024
- Author(s)
  乾達也、横田純平、河合夏苗、山下智起、浦谷悠生、植山由希子、水口裕之、
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ミトコンドリア因子MAIP1の発現低下による脂質蓄積機序の解明2024
- Author(s)
  菊池太賀、酒井英子、今泉務、Marcos Taracena-Gandara、櫻井文教、水口裕之
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 薬物代謝酵素欠損のヒト肝臓オルガノイドを用いた毒性評価系の構築2024
- Author(s)
  植山（鳥羽）由希子、今村千春、渡邊陽、水口裕之
- Organizer
  MPS実用化推進協議会第1回学術シンポジウム
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] オルガノイド培養技術を応用した高機能なヒトiPS細胞由来腸管上皮細胞の作製2024
- Author(s)
  浦谷悠生、乾達也、横田純平、山下智起、河合夏苗、植山（鳥羽）由希子、水口裕之
- Organizer
  MPS実用化推進協議会第1回学術シンポジウム
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒトiPS細胞由来肝細胞から樹立した肝オルガノイドにおける二次元培養後の機能解析2024
- Author(s)
  乾純平、永井和奏、植山（鳥羽）由希子、水口裕之
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 肝臓オルガノイド培養技術を用いた成熟肝細胞作成法の確立（創薬応用可能な新たな肝細胞モデル創出に向けた検討）2023
- Author(s)
  植山（鳥羽）由希子、仝嫣然、水口裕之
- Organizer
  第73回日本薬学会関西支部大会（受賞者講演）
- Invited
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Culturing human liver organoids using 3D nanofibers derived from chemically synthesized polymers and its application to drug-induced liver toxicity test2023
- Author(s)
  Yanran Tong, Yukiko Ueyama-Toba, Jumpei Yokota, Junko Enomoto, Haruka Yamazaki, Masaki Kanai, Hayato Matsui, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会、静岡
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Development of a pharmacokinetic evaluation system using human intestinal organoid monolayers focusing on anatomical region difference.2023
- Author(s)
  Kentaro Okada, Jumpei Yokota, Tomoki Yamashita, Tatsuya inui, Ai Ushiro, Miyu Arata, Wataru kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] The effect of cryopreservation on the functions in human iPS cell-derived hepatic organoids.2023
- Author(s)
  Wakana Nagai, Jumpei Inui, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Development of highly functional intestinal organoids of human iPS cell-derived enterocyte-like cells and their application to drug discovery research2023
- Author(s)
  Tatsuya Inui, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Yusei Uraya, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 様々な細胞株におけるCRISPR-Cas13システム適用可能性の検討2023
- Author(s)
  小阪田悠生、朝山晃、塚本智仁、酒井英子、櫻井文教、水口裕之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] ヒト肝細胞および腸管上皮細胞モデルの開発と創薬応用　～MPSへの応用に向けた課題と克服～2023
- Author(s)
  水口裕之
- Organizer
  Dialogue社Webinar
- Invited
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Analysis of function in originally developed human liver organoids-derived hepatocytes2023
- Author(s)
  Yukiko Ueyama-Toba, Yanran Tong, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒト肝臓オルガノイド由来肝細胞の機能解析と長期培養系の構築2023
- Author(s)
  植山（鳥羽）由希子、仝嫣然、村井一裕、疋田隼人、江口英利、竹原徹郎、水口裕之
- Organizer
  第30回肝細胞研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒト肝臓オルガノイド由来成熟肝細胞の分化誘導法の開発2023
- Author(s)
  植山（鳥羽）由希子、仝嫣然、水口裕之
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒトiPS細胞由来肝細胞オルガノイドに凍結保存が与える影響2023
- Author(s)
  永井和奏、乾純平、植山（鳥羽）由希子、水口裕之、
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒト腸管オルガノイド単層膜の創薬研究への応用2023
- Author(s)
  水口裕之
- Organizer
  第27回腸内細菌学会学術集会（ランチョンセミナー）
- Invited
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 両親媒性ポリマー由来三次元ナノファイバー（HYDROX）を用いた高機能なヒト腸管オルガノイドの培養2023
- Author(s)
  横田純平、植山（鳥羽）由希子、仝嫣然、岡田健太郎、浦谷悠生、岸本航、仲瀬裕志、山崎春香、叶井正樹、松井勇人、水口裕之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 創薬イノベーション・レギュレーションプラットフォーム技術ーヒトiPS細胞およびヒト生検腸管オルガノイドを用いた新規ヒト型in vitro試験系2023
- Author(s)
  水口裕之
- Organizer
  日本薬学会第143年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 両親媒性ポリマー由来三次元ナノファイバー（HYDROX）を用いたヒト肝臓オルガノイド培養とその機能解析2023
- Author(s)
  仝嫣然、植山（鳥羽）由希子、横田純平、榎本詢子、山崎春香、叶井正樹、松井勇人、水口裕之
- Organizer
  第30回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒトiPS細胞由来肝細胞を用いた肝オルガノイドの二次元培養後の機能評価2023
- Author(s)
  乾純平、永井和奏、植山（鳥羽）由希子、水口裕之
- Organizer
  第30回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Development of organoid-derived hepatocytes and enterocytes from human primary cells, biopsy, and iPS cells for pharmaceutical research2023
- Author(s)
  Hiroyuki Mizuguchi, Tatsuya Inui, Jumpei inui, Jumpei Yokota, Hiroshi Nakase, Wataru Kishimoto, Yukiko Ueyama-Toba
- Organizer
  MPS workd summit
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Highly functional human intestinal organoids in culture using 3D nanofiber (HYDROX) based on amphiphilic copolymers2023
- Author(s)
  Jumpei Yokota, Yukiko Ueyama-Toba, Yanran Tong, Kentaro Okada, Yusei Uraya, Wataru Kishimoto, Hiroshi Nakase, Junko Enomoto, Haruka Yamazaki, Masaki Kanai, Hayato Matsui, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒトiPS細胞由来肝細胞を用いた肝オルガノイドの樹立と二次元培養による創薬応用2023
- Author(s)
  乾純平、植山（鳥羽）由希子、水口裕之
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ミトコンドリア因子MAIP1の成体肝臓特異的欠損は脂質蓄積を誘導する2023
- Author(s)
  荒居千遥、酒井英子、Marcos Taracena-Gandara、増田有香、櫻井文教、水口裕之
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] オルガノイド培養技術を利用した高機能なヒトiPS細胞由来小腸上皮細胞の開発2023
- Author(s)
  乾達也、横田純平、河合夏苗、山下智起、植山由希子、水口裕之
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒト35型腫瘍溶解性アデノウイルスによるウイルス感染非依存的な抗腫瘍効果誘導機構の解析2023
- Author(s)
  徳岡空良、小野良輔、立花雅史、櫻井文教、水口裕之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] AAV8を用いた肝特異的Maip1発現はMaip1ノックアウトマウスの絶食誘発性脂肪肝の亢進を抑制する2023
- Author(s)
  荒居千遥、酒井英子、Marcos Taracena-Gandara、増田有香、櫻井文教、水口裕之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] マトリゲルに代わる三次元培養基材（HYDROXTM）を用いた高機能ヒト肝臓オルガノイドの作製2023
- Author(s)
  仝嫣然、植山（鳥羽）由希子、横田純平、山崎春香、叶井正樹、松井勇人、水口裕之
- Organizer
  第22回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ミトコンドリア因子MAIP1の成体肝臓特異的欠損は肝臓脂質蓄積および肝障害を誘導する2023
- Author(s)
  荒居千遥、酒井英子、Marcos Taracena-Gandara、増田有香、菊池太賀、櫻井文教、水口裕之
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 両親媒性ポリマー由来三次元ナノファイバー（HYDROX）のヒト肝臓オルガノイド培養への適用評価2023
- Author(s)
  仝嫣然、植山（鳥羽）由希子、横田純平、山崎春香、叶井正樹、松井勇人、水口裕之
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 創薬応用を目的としたMDR1-knockoutヒト腸管オルガノイドの樹立2022
- Author(s)
  乾達也、横田純平、野元隆我、山下智起、岡田健太郎、岸本航、仲瀬裕志、水口裕之
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] 高精度な薬物動態評価が可能なMDR1-KOヒト腸管オルガノイドの樹立2022
- Author(s)
  乾達也、横田純平、野元隆我、山下智起, 岡田健太郎, 岸本航, 仲瀬裕志, 水口裕之
- Organizer
  細胞アッセイ研究会シンポジウム：細胞アッセイ技術の現状と将来
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Evaluation of anti-tumor effects of oncolytic adenovirus serotype-35 via activation of natural killer cells2022
- Author(s)
  小野良輔、櫻井文教、水口裕之
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] NAFLD/NASH関連マイクロRNA miR-27bの標的遺伝子 Maip1 ノックアウトマウスの解析2022
- Author(s)
  増田有香、酒井英子、Marcos Taracena、櫻井文教、水口裕之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Tolloid-like 1欠損ヒトiPS細胞株を用いた胆管上皮細胞への分化過程におけるTLL1の機能解析2022
- Author(s)
  越野智葵、植山(鳥羽)由希子、山口朋子、川端健二、田中靖人、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 高効率に産生可能な35型Adベクターワクチンの開発2022
- Author(s)
  大西里佳、池本星南、塩田葵、塚本智仁、朝山晃、櫻井文教、水口裕之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] In Vitro Models for Drug Metabolism and Response in Poor Metabolizers Using Human iPS Cells and Genome Editing Technology2022
- Author(s)
  Hiroyuki Mizuguchi
- Organizer
  Gordon Research Conference Drug Metabolism
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Reovirus-mediated anti-fibrotic effects: functional restoration of hepatic stellate cells following reovirus treatment2022
- Author(s)
  Ikuho Ishigami, Shunsuke Inoue, Yuki Kibe, Shin-ichiro Nakamura, Hiroyuki Mizuguchi, Fuminori Sakurai
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] CRISPR-Cas9および-Cas12aによる遺伝子ノックイン効率の比較検討2022
- Author(s)
  朝山晃、塚本智仁、酒井英子、櫻井文教、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Maip1ノックアウトマウスにおける絶食誘発性脂肪肝の亢進は肝臓特異的Maip1発現により抑制される2022
- Author(s)
  荒居千遥、酒井英子、Marcos Taracena-Gandara、増田有香、櫻井文教、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 中和抗体回避能を有したヘキソン・ファイバー改変アデノウイルスベクターシステムの開発2022
- Author(s)
  塩田葵、北嶋祐里、池本星南、大西里佳、鎌田春彦、櫻井文教、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Adenovirus Death Protein (ADP)遺伝子を保持したアデノウイルスベクターの開発2022
- Author(s)
  塩田葵、西前文敬、櫻井文教、水口裕之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Comparison of human intestinal organoid culture media for pharmacokinetic applications2022
- Author(s)
  Jumpei Yokota, Tomoki Yamashita, Tatsuya Inui, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 35型腫瘍溶解性アデノウイルスによる抗腫瘍効果誘導メカニズムの解明2022
- Author(s)
  小野良輔、高山耕輔、櫻井文教、水口裕之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] ヒト生検由来腸管オルガノイド（enteroid）培養法の比較検討2022
- Author(s)
  横田純平、山下智起、乾達也、岸本航、仲瀬裕志、水口裕之
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Establishment of hepatocyte organoids from human iPS cell-derived hepatocytes and development of their two-dimensional culture method2022
- Author(s)
  Jumpei inui, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒトiPS細胞由来肝細胞を用いた肝オルガノイドの作製と創薬応用に向けた検討2022
- Author(s)
  乾純平、植山（鳥羽）由希子、水口裕之
- Organizer
  第29回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 腫瘍溶解性35型アデノウイルスによるNK細胞の活性化を利用した新規がん治療法の開発2022
- Author(s)
  小野良輔、櫻井文教、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] The Differentiation Potency of Human Liver Organoids Toward Biliary Epithelial Cells2022
- Author(s)
  Yanran Tong, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
- Organizer
  日本組織培養学会第94回大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 次世代アデノウイルス製剤の開発基盤研究　～遺伝子治療、ウイルス療法からワクチンまで～2022
- Author(s)
  水口裕之
- Organizer
  ACTjapanフォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] アデノウイルスベクターワクチンの鼻腔内投与によるワクチン効果誘導における基礎的検討2022
- Author(s)
  脇田拓朗、塩田葵、大西里佳、平井敏郎、吉岡靖雄、櫻井文教、櫻井文教、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Reovirus-infected cell-derived small extracellular vesicles efficiently suppress the subcutaneous tumor growth following intravenous administration in mice2022
- Author(s)
  Fuminori Sakurai, Naomi Shuwari, Chieko Inoue, Masashi Tachibana, Kentaro Jingushi, Kazutake Tsujikawa, Hiroyuki Mizuguchi
- Organizer
  14th International Virotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] レオウイルス感染腫瘍細胞由来細胞外小胞による抗腫瘍効果に関する検討2022
- Author(s)
  種昻なお実、井上智重子、神宮司健太郎、辻川和丈、水口裕之、櫻井文教
- Organizer
  第28回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] Development of a replication-incompetent adenovirus vector and oncolytic adenovirus containing microRNA-mediated post-transcriptional de-targeting system2022
- Author(s)
  Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第37回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 高精度な薬物動態評価が可能なMDR1-KOヒト腸管オルガノイドの樹立2022
- Author(s)
  乾達也、横田純平、野元隆我、山下智起, 岡田健太郎, 岸本航, 仲瀬裕志, 水口裕之
- Organizer
  細胞アッセイ研究会シンポジウム：細胞アッセイ技術の現状と将来
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Tolloid-like 1（TLL1）欠損ヒトiPS細胞株を用いた胆管上皮細胞分化誘導過程におけるTLL1の機能解析2022
- Author(s)
  越野智葵、鳥羽由希子、田中靖人、水口裕之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Involvement of IPS-1-dependent signaling in reovirus-induced tumor infiltration of CD8+ cells2022
- Author(s)
  Maho Eguchi, Masashi Tachibana, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi, Fuminori Sakurai
- Organizer
  14th International Virotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] 肝臓オルガノイドからの高機能な肝細胞の作製法開発とその応用2022
- Author(s)
  植山（鳥羽）由希子、仝嫣然、今村千春、村井一裕、下田彬允、疋田隼人、渡士幸一、江口英利、竹原徹郎、水口裕之
- Organizer
  第29回肝細胞研究会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Oncolytic adenovirus serotype-35 suppresses tumor growth via activation of natural killer cells2022
- Author(s)
  Ryosuke Ono, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  14th International Oncolytic Virotherapy Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] レオウイルスの前投与によるPEG修飾リポソームの腫瘍集積の向上に関する検討2022
- Author(s)
  櫻井文教、江口真帆、平田聖也、石神育歩、田沼将人、笠井淳司、橋本均、細川美香、大河原賢一、水口裕之
- Organizer
  第38回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] 高効率なin vivoゲノム編集を目指した核局在向上型CRISPR-Cas12aシステム搭載アデノウイルスベクターの開発2022
- Author(s)
  塚本智仁、水田陽菜、酒井英子、櫻井文教、水口裕之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] ヒト肝臓オルガノイド由来胆管上皮細胞様細胞の作製と機能解析2022
- Author(s)
  仝嫣然、植山（鳥羽）由希子、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Development of intestinal organoids with functions of human iPS cell-derived enterocyte　like cells and their application to drug discovery research2022
- Author(s)
  Tatsuya Inui, Jumpei Yokota, Kanae Kawai, Tomoki Yamashita, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 創薬応用を目的としたMDR1-knockoutヒト腸管オルガノイドの樹立2022
- Author(s)
  乾達也、横田純平、野元隆我、山下智起、岡田健太郎、岸本航、仲瀬裕志、水口裕之
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] Comparison of culture media for human enteroids from the viewpoint of pharmacokinetic studies2022
- Author(s)
  Jumpei Yokota, Tomoki Yamashita, Tatsuya Inui, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
- Organizer
  日本組織培養学会第94回大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] CRISPR-Cas9および-Cas12aによるノックイン法の比較を可能とするレポーター細胞の開発2022
- Author(s)
  朝山晃、塚本智仁、酒井英子、櫻井文教、水口裕之
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Establishment of hepatocyte organoids using human iPS cell-derived hepatocytes and their investigation for drug discovery research2022
- Author(s)
  Jumpei Inui, Yukiko Ueyama-Toba, Hiroyuki Mizuguchi
- Organizer
  日本組織培養学会第94回大会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 高いベクター産生量を示す改良型35型アデノウイルスベクターワクチンの開発2022
- Author(s)
  大西里佳、池本星南、塩田葵、塚本智仁、朝山晃、櫻井文教、水口裕之
- Organizer
  第72回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 再生医療技術を利用したヒト肝細胞および腸管上皮細胞モデルの開発と創薬応用2022
- Author(s)
  水口裕之
- Organizer
  第37回年会日本薬物動態学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] ヒト生検由来腸管オルガノイド（enteroid）培養法の比較検討2022
- Author(s)
  横田純平、山下智起、乾達也、岸本航、仲瀬裕志、水口裕之
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] 35型アデノウイルスを基本骨格とした新規腫瘍溶解性アデノウイルスの開発2021
- Author(s)
  櫻井文教、小野良輔、高山耕輔、水口裕之
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 35型アデノウイルスを基盤とした新規腫瘍溶解性アデノウイルスの開発2021
- Author(s)
  櫻井文教、小野良輔、西前文敬、水口裕之.
- Organizer
  第27回日本遺伝子細胞治療学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] Efficient anti-tumor effects of a novel oncolytic adenovirus fully composed of species B2 adenovirus serotype 352021
- Author(s)
  小野良輔、高山耕輔、櫻井文教、水口裕之
- Organizer
  第27回日本遺伝子細胞治療学会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Vinblastine作用によるヒトiPS細胞由来腸管上皮細胞の機能向上と未分化細胞排除2021
- Author(s)
  市河萌、河合夏苗、根来亮介、高山和雄、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Novel oncolytic adenovirus fully composed of adenovirus serotype 35 for treatment of pancreatic cancer.2021
- Author(s)
  小野良輔、櫻井文教、水口裕之
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Adenovirus Death Protein (ADP)を保持したアデノウイルスベクターの開発2021
- Author(s)
  塩田葵、西前文敬、櫻井文教、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 再生医療応用を目指したヒトiPS細胞由来腸管上皮細胞の作製2021
- Author(s)
  市河萌、根来亮介、河合夏苗、高山和雄、水口裕之
- Organizer
  第67回生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] miRNAによる遺伝子発現制御機構を利用した次世代アデノウイルスベクターの開発と肝障2021
- Author(s)
  櫻井文教、水口裕之
- Organizer
  第48回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 核局在性向上型Cas12a搭載アデノウイルスベクターによるゲノム編集効率の評価2021
- Author(s)
  水田陽菜、塚本智仁、酒井英子、櫻井文教、水口裕之
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 同一個人由来のヒト生検由来腸管オルガノイドとヒトiPS細胞由来腸管オルガノイドの比較検討2021
- Author(s)
  乾達也、山下智起、野元隆我、横田純平、川上賢太郎、岸本航、仲瀬裕志、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Establishment of MDR1-knockout human intestinal organoids for pharmaceutical application2021
- Author(s)
  Jumpei Yokota, Ryuga Nomoto, Tatsuya Inui, Tomoki Yamashita, Kentaro Okada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] レオウイルス感染がん細胞由来細胞外小胞のがん細胞に対する殺細胞効果の検討2021
- Author(s)
  櫻井文教、井上智重子、種昻なお実、神宮司健太郎、辻川和丈、水口裕之
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] 新規制限増殖型アデノウイルスを用いた高効率な末梢循環腫瘍細胞の検出に関する検討2021
- Author(s)
  池本星南、櫻井文教、高山耕輔、岡部隆宏、十合晋作、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Development of a novel oncolytic adenovirus based on adenovirus serotype 352021
- Author(s)
  Fuminori Sakurai, Ryosuke Ono, Hiroyuki Mizuguchi
- Organizer
  第27回日本遺伝子細胞治療学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Elucidation of the mechanism of adenovirus vector-induced hepatotoxicity during the early phase after systemic administration -involvement of inflammatory cytokine-induced leaky adenoviral gene expression2021
- Author(s)
  Fuminori Sakurai, Kahori Shimizu, Shunsuke Iizuka, Ryosuke Ono, Tomohito Tsukamoto, Fumitaka Nishimae, Shin-ichiro Nakamura, Toru Nishinaka, Tomoyuki Terada, Yasushi Fujio, and Hiroyuki Mizuguchi
- Organizer
  第27回日本遺伝子細胞治療学会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] miR-27bがヒトiPS細胞初期分化過程のBMPシグナルに対して拮抗的に働く2021
- Author(s)
  林在恩、酒井英子、櫻井文教、水口裕之
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K18247
[Presentation] CYP3A4発現Caco-2細胞株の樹立と機能評価2021
- Author(s)
  村田美治佳、市河萌、赤嶺寛樹、高山和雄、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Replication competent adenovirus (RCA) の出現を抑制可能なアデノウイルスベクターシステムの最適化2021
- Author(s)
  塩田葵、西前文敬、櫻井文教、水口裕之
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 新興・再興感染症に対するアデノウイルスベクターワクチン～COVID-19に対するワクチン開発を中心に～2021
- Author(s)
  水口裕之
- Organizer
  第25回日本ワクチン学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 生検由来ヒト腸管オルガノイドの薬物動態試験への応用2021
- Author(s)
  山下智起、乾達也、横田純平、川上賢太郎、平山大輔、野元隆我、岸本航、仲瀬裕志、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] ヒトiPS細胞および生検由来腸管上皮細胞の開発と創薬応用2021
- Author(s)
  水口裕之
- Organizer
  第28回HAB研究機構学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] 異なる血清型のアデノウイルスを基盤とした新規腫瘍溶解性アデノウイルスの開発と機能評価2021
- Author(s)
  小野良輔、高山耕輔、櫻井文教、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 薬物動態学的応用のためのヒト腸管オルガノイド培養法の比較2021
- Author(s)
  横田純平、山下智起、乾達也、岸本航、仲瀬裕志、水口裕之
- Organizer
  第67回生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] 薬物動態学的応用のためのヒト腸管オルガノイド培養法の比較2021
- Author(s)
  横田純平、山下智起、乾達也、野元隆我、川上賢太郎、岸本航、仲瀬裕志、水口裕之
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Development of a next-generation adenovirus vector containing miRNA-mediated post-transcriptional gene silencing system and elucidation of adenovirus vector-induced hepatotoxicity．2021
- Author(s)
  櫻井文教、水口裕之
- Organizer
  第48回日本毒性学会学術年会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H03817
[Presentation] アデノウイルスベクターの基本的性質、作製法、応用例について2021
- Author(s)
  水口裕之
- Organizer
  千里ライフサイエンス財団技術講習会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] Establishment of MDR1-knockout human intestinal organoids for pharmaceutical application2021
- Author(s)
  Jumpei Yokota, Ryuga Nomoto, Tatsuya Inui, Tomoki Yamashita, Kentaro Okada, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] 末梢循環腫瘍細胞の高感度な検出に向けた制限増殖型アデノウイルスの改良2020
- Author(s)
  池本星南、櫻井文教、高山耕輔、岡部隆宏、十合晋作、水口裕之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 35型アデノウイルスを基盤とした新規腫瘍溶解性ウイルスの開発と機能評価2020
- Author(s)
  小野良輔、高山耕輔、櫻井文教、水口裕之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] ヒト十二指腸オルガノイドの薬物動態評価系への応用2020
- Author(s)
  乾達也、山下智起、野元隆我、川上賢太郎、高山和雄、岸本航、仲瀬裕志、水口裕之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] ヒトiPS細胞由来腸管上皮細胞の機能向上をもたらす化合物の探索2020
- Author(s)
  市河萌、河合夏苗、根来亮介、高山和雄、水口裕之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B2 adenovirus serotype 352020
- Author(s)
  小野良輔、櫻井文教、水口裕之
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20H00664
[Presentation] 薬物トランスポーター欠損ヒトiPS細胞の作製と薬物動態試験への応用2020
- Author(s)
  河合夏苗、根来亮介、市河萌、原田和生、平田收正、高山和雄、水口裕之
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] 再生医療技術を利用したヒト肝細胞および腸管上皮細胞の作製と創薬応用2020
- Author(s)
  水口裕之
- Organizer
  薬物動態談話会第43年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] 高タイターCpf1発現アデノウイルスベクターの作製2019
- Author(s)
  塚本智仁、酒井英子、櫻井文教、水口裕之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] CRISPR-Cas12a搭載アデノウイルスベクターによるゲノム編集2019
- Author(s)
  塚本智仁、酒井英子、西前文敬、石田雄二、立野（向谷）知世、茶山一彰、櫻井文教、水口裕之
- Organizer
  第15回広島肝臓プロジェクト研究センター
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 35型アデノウイルスを基盤とした新規腫瘍溶解性アデノウイルスの開発2019
- Author(s)
  池本星南、高山耕輔、櫻井文教、水口裕之
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] ヒトiPS細胞から「小腸型」腸管上皮細胞への分化誘導法の開発と創薬応用2019
- Author(s)
  高山和雄、根来亮介、水口裕之
- Organizer
  シンポジウム「細胞アッセイ技術の現状と将来」
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] 35型アデノウイルスを基盤とした新規腫瘍溶解性アデノウイルスの開発2019
- Author(s)
  小野良輔、高山耕輔、池本星南、櫻井文教、水口裕之
- Organizer
  第69回日本薬学会関西支部総会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] プロモーター改変による高力価CRISPR-LbCas12a搭載アデノウイルスベクターの作製2019
- Author(s)
  塚本智仁、酒井英子、西前文敬、櫻井文教、水口裕之
- Organizer
  第66回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] Establishment of intestinal and hepatic drug transporter-knockout human induced pluripotent stem cell lines for pharmacokinetic studies2019
- Author(s)
  Kawai K., Negoro R., Harada K., Hirata K., Takayama K., Mizuguchi H.
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] ゲノム編集技術を利用したアデノウイルスベクターの新規改変法の開発2019
- Author(s)
  西前文敬、若林圭作、塚本智仁、櫻井文教、水口裕之
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] Adenovirus vector-induced hepatotoxicity during the early phase after systemic administration is attributed to IL-6-induced leaky expression of adenovirus genes2019
- Author(s)
  Sakurai F., Shimizu K., Iizuka S., Ono R., Tsukamoto T., Nakamura SI., Nishinaka T., Terada T., Mizuguchi H.
- Organizer
  第67回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] Cas12aの発現はアデノウイルスベクターの産生を阻害する2019
- Author(s)
  塚本智仁、酒井英子、西前文敬、櫻井文教、水口裕之
- Organizer
  日本ゲノム編集学会第4回大会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] ヒト35型アデノウイルスを基盤とした新規腫瘍溶解性ウイルスの機能評価2019
- Author(s)
  小野良輔、高山耕輔、櫻井文教、水口裕之、ヒト35型アデノウイルスを基盤とした新規腫瘍溶解性ウイルスの機能評価
- Organizer
  第4回日本遺伝子細胞治療学会 若手研究会セミナー
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] ヒトiPS細胞由来腸管単層膜の作製と薬物透過試験・薬物代謝試験への応用2019
- Author(s)
  高山和雄、根来亮介、森貴則、山浦由之、水口裕之
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] アデノウイルスベクターを用いたFc融合型血液凝固第IX因子の過剰発現による胎児期血友病治療に関する検討2019
- Author(s)
  櫻井文教、飯塚俊輔、大橋一夫、水口裕之
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 腫瘍溶解性アデノウイルスにおけるE1遺伝子発現カセットの最適化に関する検討2019
- Author(s)
  西前文敬、高山耕輔、櫻井文教、水口裕之
- Organizer
  第4回日本遺伝子細胞治療学会 若手研究会セミナー
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] ウイルス遺伝子の発現抑制により高い安全性と長期的な遺伝子発現を可能にした改良型アデノウイルスベクターの開発2019
- Author(s)
  櫻井文教、清水かほり、飯塚俊輔、塚本智仁、西前文敬、酒井英子、高山和雄、石田雄二、立野（向谷）知世、茶山一彰、水口裕之
- Organizer
  第15回広島肝臓プロジェクト研究センター
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] ヒト十二指腸オルガノイドの樹立と薬物動態評価系への応用2019
- Author(s)
  乾達也、山下智起、野元隆我、川上賢太郎、高山和雄、岸本航、仲瀬裕志、水口裕之
- Organizer
  第69 回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] Cas12aタンパク発現制御によるCRISPR-Cas12aシステム搭載アデノウイルスベクター作製技術の開発2019
- Author(s)
  塚本智仁、酒井英子、西前文敬、櫻井文教、水口裕之
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] Maturation of the enterocyte-like cells differentiated from human iPS cells using Vinblastine2019
- Author(s)
  Ichikawa M., Kawai K., Negoro R., Takayama K., Mizuguchi H.
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] CRISPR/Cpf1搭載アデノウイルスベクターの作製とヒト肝細胞キメラマウス由来肝細胞への適用2018
- Author(s)
  塚本智仁、酒井英子、櫻井文教、水口裕之
- Organizer
  第65回日本生化学会近畿支部例会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] CRISPR/Cpf1搭載アデノウイルスベクターの作製2018
- Author(s)
  塚本智仁、酒井英子、櫻井文教、水口裕之
- Organizer
  日本ゲノム編集学会第3回大会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] Suppression of oncolytic adenovirus-mediated hepatotoxicity by liver-specific inhibition of NF-kB2018
- Author(s)
  Machitani M., Sakurai F., Wakabayashi K., Tachibana M., Kato N., Fujiwara T., Mizuguchi H.
- Organizer
  第24回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] アデノウイルスと遺伝子治療、ウイルス療法2018
- Author(s)
  水口裕之
- Organizer
  第17回日本再生医療学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 高性能な腫瘍溶解性アデノウイルスの開発に向けたE1遺伝子発現カセットの最適化に関する検討2018
- Author(s)
  高山耕輔、若林圭作、櫻井文教、水口裕之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] GENERATION OF INTESTINAL EPITHELIAL CELL MONOLAYERS FROM HUMAN INDUCED PLURIPOTENT STEM CELLS BY CDX2 TRANSDUCTION2018
- Author(s)
  Takayama K, Negoro R, Mori T, Ito S, Yamaura Y, Mizuguchi H.
- Organizer
  日本薬物動態学会第33回年会
- Data Source
  KAKENHI-PROJECT-20K20381
[Presentation] アデノウイルスが発現するVA-RNAIIは、microRNAの前駆体としてAdの増殖に寄与する2018
- Author(s)
  若林圭作、町谷充洋、櫻井文教、水口裕之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] CRISPR/Cpf1搭載アデノウイルスベクターによるゲノム編集効率の評価2018
- Author(s)
  塚本智仁、酒井英子、高山和雄、櫻井文教、水口裕之
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 肝臓特異的なマイクロRNAを利用して肝障害性を低減させた新規アデノウイルスベクターによる血友病遺伝子治療に関する検討2017
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
- Organizer
  第33回日本DDS学会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] Truncated form of virus-associated RNA II, mivaRNA II, promotes adenovirus replication in a post-transcriptional gene silencing manner2017
- Author(s)
  K. Wakabayashi, M. Machitani, M. Tachibana, F. Sakurai, H. Mizuguchi
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 新規Adベクターによる血友病新生児に対する遺伝子治療効果の検討2017
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之、
- Organizer
  第17回シンポジウム遺伝子デリバリー研究会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 宿主miR-27によるSNAP25及びTXN2の発現抑制はアデノウイルス感染を阻害する2017
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Th17 promotes the induction of antigen-specific gut-mucosal CTLs following intramuscular vaccination of an adenovirus vector,2017
- Author(s)
  Hemmi M., Tachibana M., Fujimoto N., Shoji M., Sakurai F., Kobiyama K., Ishii K. J., Akira S., Mizuguchi H.
- Organizer
  第46回日本免疫学会学術集会,
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] アデノウイルスベクターワクチンによる粘膜免疫誘導メカニズム解明2017
- Author(s)
  藤本夏希、立花雅史、辺見昌久、庄司正樹、櫻井文教、審良静男、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス由来マイクロRNAによるウイルス増殖の促進2017
- Author(s)
  若林圭作、町谷充洋、立花雅史、櫻井文教、水口裕之
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing sustained transgene expression via a reduction in the leaky expression of Ad genes2017
- Author(s)
  Shunsuke Iizuka, Fuminori Sakurai, Masashi Tachibana, Kazuo Ohashi, Hiroyuki Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] アデノウイルスがコードするマイクロRNAのウイルス増殖促進機構の解明2017
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Promotion of adenovirus infection by a microRNA derived from adenovirus Virus-Associated RNA II2017
- Author(s)
  K. Wakabayashi, M. Machitani, M. Tachibana, F. Sakurai, H. Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17H00863
[Presentation] 肝臓特異的なマイクロRNAを利用して肝障害性を低減させた新規アデノウイルスベクターによる血友病遺伝子治療に関する検討2017
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Promotion of adenovirus infection by a microRNA derived from adenovirus Virus-Associated RNA II.2017
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Adenovirus vector-induced hepatotoxicity during the early phase of adenoviral treatment is attributed to inflammatory cytokine-induced leaky expression of adenovirus genes2017
- Author(s)
  Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi
- Organizer
  20th annual meeting of American society of Gene and Cell Therapy
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Adenovirus vector-induced hepatotoxicity during the early phase after systemic administration is attributed to inflammatory cytokine-induced leaky expression of adenovirus genes2017
- Author(s)
  Kahori Shimizu, Fuminori Sakurai, Shunsuke Iizuka, Masashi Tachibana, Toru Nishinaka, Tomoyuki Terada, Hiroyuki Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] miR-27 inhibits adenovirus infection via the suppression of SNAP25 and TXN2 expressions2017
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第23回日本遺伝子細胞治療学会学術集会
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] アデノウイルスがコードするマイクロ RNA のウイルス増殖促進機構の解明2017
- Author(s)
  若林圭作、町谷充洋、立花雅史、櫻井文教、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] 高効率かつ長期的な遺伝子発現が可能な新規Adベクターによる血友病B遺伝子治療効果の検討2017
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター、東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing2016
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana、Fuminori Sakurai、Hiroyuki Mizuguchi
- Organizer
  The 24th Annual Congress of European Society of Gene and Cell Therapy
- Place of Presentation
  フィレンツェ、イタリア
- Year and Date
  2016-10-18
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing2016
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  European Society of Gene and Cell Therapy (ESGCT) 2016 Annual Congress
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス外殻蛋白質に対する抗体がアデノウイルスベクターによる遺伝子導入に与える影響の解析2016
- Author(s)
  冨田恭子、櫻井文教、町谷充洋、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Type I IFN signaling regulates the antigen-specific mucosal immunity following systemic administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  European Society of Gene and Cell Therapy (ESGCT) 2016 Annual Congress
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA2016
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  The 22nd annual meeting of JSGCT
- Place of Presentation
  東京
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Type I IFN signaling plays an important role in recruiting inflammatory monocytes following adenovirus vector vaccination2016
- Author(s)
  Natsuki Fujimoto, Masashi Tachibana, Masahisa Hemmi, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス外殻蛋白質に対する抗体がアデノウイルスベクターによる遺伝子導入に与える影響の解析2016
- Author(s)
  冨田恭子、櫻井文教、町谷充洋、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I interferons impede short-hairpin RNA-mediated RNA interference via inhibition of dicer-mediated processing to small interfering RNA2016
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第22回日本遺伝子細胞治療学会総会
- Place of Presentation
  虎ノ門ヒルズフォーラム(東京)
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] I型IFNによるCRISPR/Cas9システムを用いたゲノム編集効率の低下2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、中谷光佑、高山和雄、立花雅史、水口裕之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  東京
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] ウイルス遺伝子の発現を低減させた改良型アデノウイルスベクターの新生仔マウスにおける遺伝子導入特性の解明と血友病遺伝子治療に関する検討2016
- Author(s)
  飯塚俊輔、櫻井文教、立花雅史、大橋一夫、水口裕之
- Organizer
  第32回日本DDS学会学術集会
- Place of Presentation
  静岡コンベンションアーツセンター (静岡県静岡市)
- Year and Date
  2016-06-30
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Effects of antibodies against adenoviral capsid proteins on adenovirus vector-mediated in vivo transduction2016
- Author(s)
  Kyoko Tomita, Fuminori Sakurai, Mitsuhiro Machitani, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  European Society of Gene and Cell Therapy (ESGCT) 2016 Annual Congress
- Place of Presentation
  フィレンツェ（イタリア）
- Year and Date
  2016-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] CRISPR/Cas9システム搭載アデノウイルスベクターの開発と機能評価2016
- Author(s)
  中谷光佑、町谷充洋、高山和雄、立花雅史、櫻井文教、水口裕之
- Organizer
  第66 回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪薬科大学（大阪府高槻市）
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルスが発現するマイクロRNAの機能解析2016
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  東京
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] I型IFNによるCRISPR/Cas9システムを用いたゲノム編集効率の低下2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、中谷光佑、高山和雄、立花雅史、水口裕之
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] miR-27によるCyclin G1の発現抑制がアデノウイルス感染に与える影響2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Neonatal gene therapy for hemophilia B by a novel adenovirus vector showing reduction in the leaky expression of viral genes.2016
- Author(s)
  Shunsuke Iizuka, Fuminori Sakurai, Masashi Tachibana, Kazuo Ohashi, Hiroyuki Mizuguchi
- Organizer
  第22回日本遺伝子細胞治療学会
- Place of Presentation
  虎ノ門ヒルズ (東京都)
- Year and Date
  2016-07-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] miR-27によるCyclin G1の発現抑制がアデノウイルス感染に与える影響2016
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induces inflammatory DCs following intramuscular administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター、ラグナガーデンホテル（沖縄県宜野湾市）
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induces inflammatory DCs following intramuscular administration of an adenovirus vector vaccine2016
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Fujimoto Natsuki, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第24回マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  ソラシティカンファレンスセンター（東京都千代田区）
- Year and Date
  2016-06-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] 全身系投与型アデノウイルスベクターワクチンによる粘膜免疫誘導に重要なⅠ型IFNシグナルの解析2016
- Author(s)
  辺見昌久、立花雅史、藤本夏希、庄司正樹、櫻井文教、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] CRISPR/Cas9システム搭載Adベクターの開発と機能評価2016
- Author(s)
  中谷光佑、町谷充洋、高山和雄、立花雅史、櫻井文教、水口裕之
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling regulates the antigen-specific mucosal immunity following systemic vaccination of an adenovirus vector2015
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Kenji Kawabata, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Inhibitory effects of adenovirus neutralizing antibodies against different adenoviral capsid proteins on transduction with an adenovirus vector2015
- Author(s)
  Kyoko Tomita, Fuminori Sakurai, Mitsuhiro Machitani, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Expression profile of virus-associated RNAI following transduction with a replication-incompetent adenovirus vector in vitro and in vivo.2015
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Kahori Shimizu, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡県福岡市)
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルスベクターワクチンによる獲得免疫誘導機構の解明2015
- Author(s)
  藤本夏希、立花雅史、辺見昌久、庄司正樹、櫻井文教、小檜山康司、川端健二、石井健、審良静男、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学（大阪府富田林市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス感染に対する防御機構としてのDicerの役割2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第38回日本分子生物学会年会第88回日本生化学大会合同大会
- Place of Presentation
  神戸ポートアイランド (兵庫県神戸市)
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス感染に対する防御機構としてのDicerの役割2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第38回　日本分子生物学会年会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] 筋肉内投与されたアデノウイルスベクターワクチンによる腸管粘膜免疫誘導に重要なⅠ型IFNシグナルの解析2015
- Author(s)
  辺見昌久、立花雅史、続木沙也加、庄司正樹、櫻井文教、川端健二、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Type I IFN signaling induced by systemically administrated adenovirus vector promotes the antigen-specific mucosal immunity2015
- Author(s)
  Masahisa Hemmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Kenji Kawabata, Kouji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2015-07-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] NF-κB mediates leaky expression of adenovirus genes in a replication-incompetent adenovirus vector2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場 (大阪府大阪市)
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Inhibition of in vivo transduction with adenovirus vectors via antibodies against adenovirus capsid proteins2015
- Author(s)
  Kyoko Tomita, Fuminori Sakurai, Mitsuhiro Machitani, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Adenovirus vectors2015
- Author(s)
  Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場 (大阪府大阪市)
- Year and Date
  2015-07-24
- Invited
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Quantitative analysis of virus-associated RNAI expression following transduction with a replication-incompetent adenovirus vector in vitro and in vivo.2015
- Author(s)
  Keisaku Wakabayashi, Mitsuhiro Machitani, Kahori Shimizu, Masashi Tachibana, Fuminori Sakurai, Hiroyuki Mizuguchi
- Organizer
  第21回日本遺伝子治療学会総会
- Place of Presentation
  大阪国際会議場 (大阪府大阪市)
- Year and Date
  2015-07-25
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス由来小分子RNAの機能特性に立脚した遺伝子治療用組み換えウイルスの開発2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会
- Place of Presentation
  大阪大谷大学 (大阪府富田林市)
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] TBK1 and type I IFN signaling play different roles in the induction of antigen-specific adaptive immunity following adenovirus vector vaccination2015
- Author(s)
  Natsuki Fujimoto, Masashi Tachibana, Masahisa Hemmi, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Kenji Kawabata, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Reduction in the leaky expression of Ad genes from a replication-incompetent adenovirus vector by inhibition of NF-κB2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第74回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場 (愛知県名古屋市)
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Inhibition of NF-κB leads to suppression of Ad vector-mediated hepatotoxicities via reduction in the leaky expression of Ad genes2015
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  福岡国際会議場 (福岡県福岡市)
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルス由来小分子RNAの機能特性に立脚した新規腫瘍溶解性ウイルスの開発2015
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第65回日本薬学会近畿支部総会・大会
- Place of Presentation
  大阪府富田林市
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] アデノウイルスベクターの新生児マウスにおける遺伝子発現特性の解析2014
- Author(s)
  飯塚俊輔、櫻井文教、清水かほり、立花雅史、水口裕之
- Organizer
  第64回日本薬学会近畿支部総会
- Place of Presentation
  京都薬科大学（京都府京都市）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerのノックダウンによるアデノウイルスベクター用新規パッケージング細胞の開発2014
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  第64回日本薬学会近畿支部総会
- Place of Presentation
  京都薬科大学（京都府京都市）
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerのノックダウンによるアデノウイルスベクター用新規パッケージング細胞の開発2014
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Apoptosis-resistant and Highly Functional Islet Cell Sheets for Transplantation2014
- Author(s)
  Hanayama H, Ohashi K, Utoh R, Ise K, Shimizu T, Yamato M, Mizuguchi H, Sakurai F, Okano T, Gotoh M.
- Organizer
  2014 World Transplant Congress
- Place of Presentation
  サンフランシスコ
- Data Source
  KAKENHI-PROJECT-24300174
[Presentation] レオウイルスによる低酸素誘導因子HIF-1α発現量低下における核酸認識受容体の2014
- Author(s)
  宝谷拓磨、立花雅史、水口裕之、櫻井文教
- Organizer
  第64回日本薬学会近畿支部総会・大会
- Place of Presentation
  京都薬科大学
- Year and Date
  2014-10-11
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] 組織特異的ターゲティングを目指した Monobody 提示型 Ad ベクターの開発2013
- Author(s)
  松井勇人、櫻井文教、形山和史、阿部康弘、町谷充洋、倉知慎之輔、立花雅史、水口裕之
- Organizer
  日本薬学会第133 年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] アデノウイルスベクター局所投与による遺伝子発現への抗アデノウイルス抗体の影響2012
- Author(s)
  冨田恭子、櫻井文教、庄司正樹、立花雅史、水口裕之
- Organizer
  日本薬学会第132回年会
- Place of Presentation
  北海道
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] Development of a Novel targeted Adenovirus Vector Displaying Monobody Binding to Anti-Vascular Endothelial Growth Factor Receptor 2 in a Fiber Protein.2012
- Author(s)
  Matsui H, Sakurai F, Tachibana M, Kurachi S, Katayama K, Mizuguchi H
- Organizer
  American Society of Gene & Cell Therapy 15th Annual Meeting
- Place of Presentation
  アメリカ (フィラデルフィア)
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] IN VITRO TRANSDUCTION PROPERTIES OF A NOVEL TARGETED ADENOVIRUS VECTOR DISPLAYING MONOBODY BINDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 IN A FIBER PROTEIN.2012
- Author(s)
  Matsui H, Sakurai F, Tachibana M, Kurachi S, Katayama K, Mizuguchi H
- Organizer
  第18回日本遺伝子治療学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] 血液凝固因子(FX) を利用した新規 PEG 化アデノウイルスベクターの開発2012
- Author(s)
  松井勇人、櫻井文教、形山和史、山口朋子、岡本小百合、高比良幸大、立花雅史、水口裕之
- Organizer
  第28回日本DDS学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] EFFECT OF ADENOVIRUS-NEUTRALIZING ANTIBODY ON ADENOVIRUS VECTOR-MEDIATED TRANSGENE EXPRESSION FOLLOWING INTRATUMORAL INJECTION2012
- Author(s)
  Tomita K, Sakurai F, Tachibana M, Mizuguchi H
- Organizer
  第18回日本遺伝子治療学会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] In Vitro Transduction Properties of Fiber-substituted Adenovirus Vectors Containing Foreign Peptides in the Adenovirus Serotype 35 Fiber Knob.2011
- Author(s)
  Matsui H, Sakurai F, Katayama K, Kurachi S, Tashiro K, Sugio K, Kawabata K, Mizuguchi H
- Organizer
  The 6thSeoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
- Place of Presentation
  韓国(ソウル)
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] ENHANCED TRANSDUCTION EFFICIENCIES OF FIBER-SUBSTITUTED ADENOVIRUS VECTORS BY INCORPORATION OF RGD PEPTIDE IN TWO DISTINCT REGIONS OF ADENOVIRUS SEROTYPE 35 FIBER KNOB2010
- Author(s)
  Matsui H, Sakurai F, Katayama K, Kurachi S, Tashiro K, Sugio K, Kawabata K, Mizuguchi H
- Organizer
  第16回日本遺伝子治療学会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] Drosha 非依存マイクロRNA"mirtron"は哺乳類細胞でも機能する。2010
- Author(s)
  成井信博、酒井英子、三浦祐介、形山和史、櫻井文教、川端健二、水口裕之
- Organizer
  第33回日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-21659020
[Presentation] ラクダ抗体重鎖可変ドメインによる細胞特異的ターゲティングを目指した新規 Ad ベクターの開発2010
- Author(s)
  松井勇人、形山和史、櫻井文教、倉知慎之輔、田代克久、川端健二、萩原義久、水口裕之
- Organizer
  第26回日本 DDS 学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] 特異的標的化を可能とするアデノウイルスベクターの開発2010
- Author(s)
  水口裕之
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
- Place of Presentation
  神戸(招待講演)
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] 次世代アデノウイルスベクターの開発と生命科学研究への応用2010
- Author(s)
  水口裕之
- Organizer
  第26回日本DDS学会
- Place of Presentation
  大阪(招待講演)
- Data Source
  KAKENHI-PROJECT-22390030
[Presentation] Adenovirus serotype 35 vector-mediated gene transfer into cynomolgus monkeys2007
- Author(s)
  水口裕之, 他
- Organizer
  アメリカ遺伝子治療学会第11回年会
- Place of Presentation
  米国、シアトル
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Presentation] Intravenous delivery of adenovirus serotype 35 vectors in nonhuman primates.2007
- Author(s)
  Fuminori Sakurai, Kimiyo Akitomo, Shin-ichno Nakamura, Hiroaki Shibata Keiji Terao, Kenji Kawabata, Hiroyuki Mizuguchi
- Organizer
  Japan Society of Gene Therapy, the 13th annual meeting 2007
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Presentation] Transduction properties of adenovirus serotype 35 vectors in cynomolgus monkeys.2007
- Author(s)
  Fuminori Sakurai, Kimiyo Akatomo, Kenji Kawabata, Shin-ichiro Nakamura, Hiroaki Shibata, Kenji Terao, Takao Hayakawa, Hiroyuki Mizuguchi
- Organizer
  The 127th annual meeting of the Pharmeceutical Society of Japan
- Place of Presentation
  Toyama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Presentation] Adenovirus serotype 35 vector-mediated gene transfer into cynomolgus monkeys.2007
- Author(s)
  Hiroyuki Mizuguchi, Fuminori Sakurai, Kimiyo Akitomo, Shin-ichiro Nakamura, Hiroaki Shibata, Keiji Terao, Kenji Kawabata
- Organizer
  11th annual meeting American Society of Gene Therapy
- Place of Presentation
  Seattle, USA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Presentation] Transduction properties of adenovirus serotype 35 vectors in cynomolgus monkeys.2007
- Author(s)
  Fuminori Sakurai, Kimiyo Akitomo, Kenji Kawabata, Shin-ichiro Nakamura, Hiroaki Shibata, Keiji Terao, Takao Hayakawa, Hiroyuki Mizuguchi
- Organizer
  The 23th annual meeting of Drng Delivery System
- Place of Presentation
  Kumamoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Presentation] Identification of domains in human CD46 involved in Ad35 vector-mediated transduction.2006
- Author(s)
  Sayaka Murakami, Fuminori Sakurai, Kenji Kawabata, Naoki Okada, Tsukasa Seya, Akira Yamamoto, Takao Hayakawa, Hiroyuki Mizuguchi
- Organizer
  The 126th annual meeting of the Pharmeceutical Society of Japan
- Place of Presentation
  Sendai
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Presentation] Evaluation of adenovirus serotype 35 vector-mediated gene transfer in cynomolgus monkeys.2006
- Author(s)
  Fuminori Sakurai, Kimiyo Akatomo, Kenji Kawabata, Shin-ichiro Nakamura, Hiroaki Shibata, Kenji Terao, Takao Hayakawa, Hiroyuki Mizuguchi
- Organizer
  The 22th annual meeting of the Japan Society of Drug Delivery System
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390047
[Presentation] Dicerはアデノウイルス由来小分子RNA（VA-RNA）の切断を介してアデノウイルスの感染を抑制する
- Author(s)
  櫻井文教、町谷充洋、若林圭作、立花雅史、水口裕之
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] 膵島組織工学を目指した単離膵島細胞へのファイバー改変アデノウイルスベクターによる遺伝子導入
- Author(s)
  花山寛之、大橋一夫、鵜頭理恵、伊勢一哉、櫻井文教、水口裕之、岡野光夫、後藤満一
- Organizer
  第４１回日本臓器保存生物医学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2014-11-28 – 2014-11-29
- Data Source
  KAKENHI-PROJECT-24300174
[Presentation] Post-transcriptional Gene Silencing機構を利用した高機能型遺伝子組換えアデノウイルスの開発
- Author(s)
  櫻井文教、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学・兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerはアデノウイルス由来小分子RNA（VA-RNA）の切断を介してアデノウイルスの感染を抑制する
- Author(s)
  櫻井文教、町谷充洋、若林圭作、立花雅史、水口裕之
- Organizer
  第62回ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Type-I IFN signaling induced by systemically administrated adenovirus vector promotes the antigen-specific mucosal immunity
- Author(s)
  Masahisa Henmi, Masashi Tachibana, Sayaka Tsuzuki, Masaki Shoji, Fuminori Sakurai, Koji Kobiyama, Ken J. Ishii, Shizuo Akira, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting 2014
- Place of Presentation
  ワシントンDC（USA）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] レオウイルスによる低酸素誘導因子HIF-1α発現量低下に関する分子機構の解明
- Author(s)
  宝谷拓磨、立花雅史、水口裕之、櫻井文教
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Activity levels of cathepsin B and L are crucial factors determining reovirus-mediated tumor cell lysis
- Author(s)
  Fuminori Sakurai, Yuki Katayama, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] 新生仔マウスにおけるアデノウイルスベクターによる遺伝子導入特性の解析
- Author(s)
  飯塚俊輔、櫻井文教、清水かほり、立花雅史、大橋一夫、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学・兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerノックダウン細胞を用いたアデノウイルスベクター作製効率の改善に関する検討
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学・兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] アデノウイルスベクターワクチンにより誘導されるⅠ型IFNシグナルを介した腸管粘膜免疫誘導のメカニズム解明
- Author(s)
  辺見昌久、立花雅史、続木沙也加、庄司正樹、櫻井文教、川端健二、小檜山康司、石井健、審良静男、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] 膵島組織工学を目指した単離膵島細胞へのファイバー改変アデノウイルスベクターによる遺伝子導入
- Author(s)
  花山寛之、大橋一夫、鵜頭理恵、伊勢一哉、櫻井文教、水口裕之、岡野光夫、後藤満一
- Organizer
  第４１回日本臓器保存生物医学会総会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2014-11-28 – 2014-11-29
- Data Source
  KAKENHI-PROJECT-26670587
[Presentation] Post-transcriptional Gene Silencing機構を利用した高機能型遺伝子組換えアデノウイルスの開発
- Author(s)
  櫻井文教、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] microRNA依存的にウイルス遺伝子の発現を抑制可能な新規アデノウイルスベクターの開発
- Author(s)
  櫻井文教、清水かほり、冨田恭子、長基康人、立花雅史、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] NF-κBがアデノウイルスの増殖に及ぼす影響に関する検討
- Author(s)
  町谷充洋、櫻井文教、清水かほり、立花雅史、水口裕之
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Cathepsin activity levels in tumor cells are a crucial determinant for reovirus oncolysis
- Author(s)
  Fuminori Sakurai, Yuichi Terasawa, Masahi Tachibana, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting
- Place of Presentation
  ワシントンDC
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] MICRORNA PROCESSING FACTORS REGULATE ADENOVIRUS REPLICATION
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第20回日本遺伝子治療学会総会
- Place of Presentation
  慈恵医科大学
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Evaluation of involvement of microRNA processing factors in adenovirus replication
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting
- Place of Presentation
  ワシントンDC
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] miR-27はCyclin G1の発現抑制を介してアデノウイルスの増殖を阻害する
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Development of a novel oncolytic adenovirus expressing a short-hairpin RNA against a microRNA processing factor
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] RNA干渉に関わる因子であるDicerはアデノウイルスに対する防御機構として機能する
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] マイクロRNAプロセシング因子の制御による腫瘍溶解性アデノウイルスの機能向上
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶応大学薬学部
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] Evaluation of involvement of microRNA processing factors in adenovirus replication
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  American Society of Gene & Cell Therapy, 17th Annual Meeting 2014
- Place of Presentation
  ワシントンDC（USA）
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] RNA干渉に関わる因子であるDicerはアデノウイルスに対する防御機構として機能する
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学・兵庫医療大学（兵庫県神戸市）
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Development of a novel oncolytic adenovirus expressing a short-hairpin RNA against a microRNA processing factor
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Masashi Tachibana, Toshiyoshi Fujiwara, Hiroyuki Mizuguchi
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] Dicerノックダウン細胞を用いたアデノウイルスベクター作製効率の改善に関する検討
- Author(s)
  若林圭作、町谷充洋、櫻井文教、立花雅史、水口裕之
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293118
[Presentation] マイクロRNAプロセシング因子の制御による腫瘍溶解性アデノウイルスの機能向上
- Author(s)
  町谷充洋、櫻井文教、若林圭作、立花雅史、藤原俊義、水口裕之
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  慶應義塾大学薬学部　芝共立キャンパス（東京都港区）
- Year and Date
  2014-07-30 – 2014-07-31
- Data Source
  KAKENHI-PROJECT-26242048
[Presentation] MICRORNA PROCESSING FACTORS REGULATE ADENOVIRUS REPLICATION
- Author(s)
  Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi
- Organizer
  第20回日本遺伝子治療学会総会
- Place of Presentation
  慈恵医科大学（東京都港区）
- Year and Date
  2014-08-06 – 2014-08-08
- Data Source
  KAKENHI-PROJECT-26242048

1. SAKURAI FUMINORI (70370939)

# of Collaborated Projects: 8 results

# of Collaborated Products: 121 results
2. KAWABATA Kenji (50356234)

# of Collaborated Projects: 5 results

# of Collaborated Products: 25 results
3. OHASHI Ohashi (40364062)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
4. TACHIBANA MASASHI (80513449)

# of Collaborated Projects: 3 results

# of Collaborated Products: 82 results
5. NAKAYAMA Masamichi (00338980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. IWATA Hiroo (30160120)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TATSUMI Kohei (70555432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TAKEWA Yoshiaki (20332405)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TAENAKA Yoshiyuki (00142183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TATSUMI Eisuke (00216996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. HONMA Akihiko (20287428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. SUMIKURA Hirohito (20433998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. OHNUMA Kentarou (50527992)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. HANADA Shigeru (90514547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. KAKUTA Yukihide (30443485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. FUJII Yutaka (20589303)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKAKI Miyako (00033358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HAYAKAWA Takao (50124392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. HARASHIMA Hideyoshi (00183567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. KAMIYA Hiroyuki (10204629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. MATSUDA Akira (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. TERAO Keiji (30109920)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAMURA Shin-ichiro (50307980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
24. YAMADA Masumi (30546784)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. SUGIMOTO Mitsuhiko (80192128)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. Yagi Hiroshi (20327547)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 中西剛 (50303988)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 田中慶一 (90068247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 中川晋作 (70207728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. 須藤亮 (20407141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 仲瀬裕志 (60362498)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
32. 清水健太郎 (60379203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 上田安希子 (40942587)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 大西伸也 (60892932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 小倉裕司 (70301265)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. SUZUKI Yousuke

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. NOMURA Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. TAZAWA Hiroshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 寺尾恵治

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
40. 清水かほり

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 山崎玲奈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 藤尾慈

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizuguchi Hiroyuki 水口 裕之

MIZUGUCHI Hiroyuki 水口 裕之

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Development of recombinant adenovirus medicinesPrincipal Investigator

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ゲノム編集とiPS細胞やオルガノイド培養技術を用いたヒトモデル表現型解析系の開発Principal Investigator

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Development of novel recombinant adenovirusesPrincipal Investigator

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Development of human biopsy-derived intestinal organoids monolayers and application for pharmaceutical researchPrincipal Investigator

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Development of novel adenovirus vectors through the analysis of the virus with mammalian cellsPrincipal Investigator

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The development of novel adenovirus vectors and application for treatment, prevention, and diagnosis of diseasesPrincipal Investigator

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Regulation of mammalian neuronal system by a novel microRNA "mirtron".Principal Investigator

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The development of the novel targeted adenovirus vectorsPrincipal Investigator

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Mizuguchi Hiroyuki 水口裕之

MIZUGUCHI Hiroyuki 水口裕之