AKUTSU Hidenori 阿久津英憲

Researcher Number	50347225
Other IDs
Affiliation (Current)	2024: 国立研究開発法人国立成育医療研究センター, 再生医療センター, センター長 2024: 国立研究開発法人国立成育医療研究センター, 生殖医療研究部, 部長
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人国立成育医療研究センター, 再生医療センター, センター長 2015 – 2024: 国立研究開発法人国立成育医療研究センター, 生殖医療研究部, 部長 2016: 国立成育医療研究センター研究所, 生殖医療研究部, 部長 2015 – 2016: 国立研究開発法人国立成育医療研究センター, その他部局等, その他 2015: 国立成育医療研究センター, 生殖・細胞医療研究部, 部長 … More 2014: 独立行政法人国立成育医療研究センター, 生殖医療研究部, その他 2014: 独立行政法人国立成育医療研究センター, 細胞医療研究部, 部長 2014: 独立行政法人国立成育医療研究センター, 室長 2012 – 2014: 独立行政法人国立成育医療研究センター, その他部局等, その他 2009 – 2013: National Research Institute for Child Health and Development, 生殖・細胞医療研究部, 室長 2012: 国立成育医療研究センター, 生殖・細胞医療研究部, 室長 2011: 国立成育医療センター研究所, 生殖・細胞医療研究部, 室長 2010: 独立行政法人国立成育医療研究センター, 研究所・生殖・細胞医療研究部, 室長 2009: 国立成育医療センター(研究所), 生殖細胞医療研究部・生殖技術研究室, 室長 2008 – 2009: 国立成育医療センター(研究所), 生殖・細胞医療研究部, 室長 2007 – 2009: 国立成育医療センター研究所, 生殖医療研究部, 室長 2008: 国立成育医療センター(研究所), 生殖・細胞医療研究室, 室長 2008: 国立成育医療センター(研究所), 生殖技術研究室, 室長 2008: 国立成育医療センター, 研究所, 室長 2007: 国立成育医療センター(研究所), 生殖医療研究部, 共同研究員 2007: 国立成育医療センター(研究所), 生殖医療研究部, 室長 2006: 国立成育医療センター(研究所), 生殖医療研究部, 研究員 Less
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Medium-sized Section 90:Biomedical engineering and related fields Except Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Human pathology / Basic Section 64010:Environmental load and risk assessment-related / Basic Section 55020:Digestive surgery-related / Basic Section 55010:General surgery and pediatric surgery-related … More / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Transformative Research Areas, Section (I) / Embryonic/Neonatal medicine / Applied pharmacology / Urology Less
Keywords	Principal Investigator 受精卵 / X染色体 / 不育症 / 生殖医学 / X染色体不活化 / Oct4 / クロマチン / 女性医学 / 全能性 / 卵子 … More / マイクロアレイ / 発生 / 老化 / 卵子加齢 / 幹細胞 / female細胞 / ヒト受精胚 / 生命発動 / 器官発生 / 味蕾 / 小腸 / オルガノイド / 腸管栄養 / iPS細胞 / 腸管オルガノイド / ヒストン修飾 / DNAメチル化 / 胎盤発生 / 着床 / 初期胚 / Xist / ヒストン / Ｘ染色体 / 不妊症 / 卵子クロマチン / 卵子成熟過程 / 卵 / β-Catenin / 成熟 / 核タンパク質 / マイクロインジェクション / 初期化 / 受精 / リプログラミング / 若返り / 網羅的遺伝子発現解析 / 胚細胞腫瘍 / 卵細胞 / ES細胞 … More Except Principal Investigator iPS細胞 / 生殖医学 / インプリンティング / ZGA / 着床前期胚 / 受精 / 再生医療 / 初期化 / ES細胞 / 子宮内膜 / オクタン酸 / 体外受精 / マウス / 発現プロファイリング / テロメア / 新規遺伝子 / 幹細胞 / 細胞移植 / 遺伝子発現プロファイリング / CD9 / エンハンサー / スーパーエンハンサー / エンハンサー・プロモーター相互作用 / 胎盤 / クロマチン高次構造 / メタボローム / ATP産生 / mtDNA / 代謝 / ミトコンドリア / 核置換 / 胚性ゲノム活性化 / ゲノム安定性 / 多能性幹細胞 / 臓器イメージング / ライトシート顕微鏡 / 組織透明化 / MPS / オルガノイド / SLC10A2 / CMV感染症 / ミニ腸 / 腸管オルガノイド / ヒトサイトメガロウイルス (CMV) / 幹細胞生物学 / エピジェネティクス / 初期発生 / 尊厳の毀損 / 安楽死 / 生命操作による尊厳の毀損 / 反延命主義 / 尊厳死 / 先端医療技術 / ゲノム編集 / 炎症性腸疾患 / 先天性貧血 / 体重 / 胎仔 / 体外培養 / CYP11B1 / CYP21A2 / SF1 / 副腎皮質過形成症 / 11β水酸化酵素欠損症 / 21水酸化酵素欠損症 / アデノウィルス随伴ウィルスベクター / 遺伝子治療 / 先天性副腎皮質過形成症 / ケモカイン / 腫瘍内マクロファージ / TAM誘導 / 癌幹細胞 / 腫瘍微小環境の変化 / パクリタキセル耐性 / 線維芽細胞 / 炎症細胞 / 癌微小環境 / 化学療法 / 卵巣癌 / 神経幹細胞 / リプログラミング / 生殖医療 / 培養液 / 胚盤胞 / 卵胞 / miRNA / エクソソーム / 細胞外分泌顆粒 / 胚 / ヒト / 胚発生 / 非遺伝母由来HLA抗原 / microchimerism / 先天性代謝異常症 / 造血幹細胞移植 / 免疫寛容 / 胎児治療 / MEP50 / ゲノム不安定性 / 染色体ギャップ / SCAN / 遺伝子発現パターン / 創薬 / 分化誘導 / 筋萎縮性側索硬化症 / メタロチオネイン / 神経変性疾患 / 短命 / 早期老化 / 産仔数 / DMR / トランスクリプトｰム / 転写因子 / 再生医学 / 発生 / β-カテニン / 細胞接着 / β-カドヘリン / E-カドヘリン / βカテニン / 接着 / トランスジェニック・マウス / RNAi / 胚性幹細胞 / 卵 / 中心体 / 精子機能 / 精子中心体 / 不妊症 / アンドロロジー / テトラスバニン / テトラスパニン / チューブリン / エキソソーム / 膜融合 / 循環器・高血圧 / 移植・再生医療 / バイオインフォマティックス / 液性因子 / 高血圧 / 移植 / 循環器 Less

Organ/Organoid imaging of genomic stress and inflammation induced by environmental factors
- Principal Investigator
  
  大塚健介
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 64010:Environmental load and risk assessment-related
- Research Institution
  Central Research Institute of Electric Power Industry
Human Dignity and Advanced Medical Studies
- Principal Investigator
  
  田坂さつき
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (I)
- Research Institution
  Rissho University
ヒト幹細胞とゲノム・エピゲノム編集による初期発生原理の統合的理解
- Principal Investigator
  
  福田篤
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Tokai University
ミニ腸による日和見CMV腸炎制御へ向けた感染予測・制御機序の研究
- Principal Investigator
  
  内田孟
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  National Center for Child Health and Development
Development of a drug assay system using a miniature gut organoid model of congenital diarreal disorders
- Principal Investigator
  
  三森浩太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  National Center for Child Health and Development
Elucidation of 3D genome architecture of human placental and endometrial cells
- Principal Investigator
  
  中林一彦
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  National Center for Child Health and Development
乳児に発症する炎症性腸疾患と造血不全の原因となる新たな単一遺伝子疾患の確立
- Principal Investigator
  
  竹内一朗
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
生命発動と器官発生・制御に関わるヒト受精胚分子機序の解明Principal Investigator
- Principal Investigator
  
  阿久津英憲
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  National Center for Child Health and Development
全能性獲得へのロードマップ：幹細胞のミトコンドリア・ゲノム安定性機構の解明
- Principal Investigator
  
  山田満稔
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
Development of gene therapy for congenital adrenal hyperplasia using AAV vectors and iPS cells
- Principal Investigator
  
  Naiki Yasuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
Development of a Human Taste-Small Intestine-Brain Correlation Model applying for Nutritional PhysiologyPrincipal Investigator
- Principal Investigator
  
  Akutsu Hidenori
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  National Center for Child Health and Development
Genetic alteration from in-vitro culture environment in mammalian offspring born through in vitro fertilization
- Principal Investigator
  
  NAOKI KJI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tokyo Medical University
Microenvironment of advanced ovarian cancer after chemotherapy
- Principal Investigator
  
  SOEDA SHU
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Fukushima Medical University
Elucidation of oocyte molecular mechanism on imprinted X chromosome inactivation enabling a sequential developmentPrincipal Investigator
- Principal Investigator
  
  Akutsu Hidenori
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Center for Child Health and Development
Roles of exosomes in reproductive system
- Principal Investigator
  
  HAMATANI TOSHIO
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University
Elucidation of imprinting type X chromosome inactivation mechanism of oocytes grasped from chromatin dynamicsPrincipal Investigator
- Principal Investigator
  
  Akutsu Hidenori
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Center for Child Health and Development
Effect of Octanoic acid and lipid metabolism in preembryo and pluripotent stem cells culture
- Principal Investigator
  
  KUJI NAOAKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Tokyo Medical University
Study for the molecular mechanism in an oocyte agingPrincipal Investigator
- Principal Investigator
  
  Akutsu Hidenori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Center for Child Health and Development
Exploit of an alternative stem cell transplantation in utero based on feto-maternal tolerance using allogeneic donor cells immunologically matched to the mother.
- Principal Investigator
  
  Ihara Norimasa
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  National Center for Child Health and Development
molecular mechanisms of genomic rejuvenation during preimplantation development
- Principal Investigator
  
  HAMATANI TOSHIO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University
Study for defining totipotency mechanism of oocytesPrincipal Investigator
- Principal Investigator
  
  Akutsu Hidenori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Center for Child Health and Development
Generation of high-quality embryonic stem cells by new reprogramming technique and a basic research for regenerative medicine
- Principal Investigator
  
  MIURA TAKUMI
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Institute of Health Sciences
  National Research Institute for Child Health and Development
Drug development using iPS cells derived from the dental pulp of the patients with neurodegenerative diseases, and metallothionein
- Principal Investigator
  
  HOZUMI Isao
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Gifu Pharmaceutical University
Gene cascades for starting development and generating totipotency
- Principal Investigator
  
  HAMATANI Toshio
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University
Research for exploring totipotency of mouse zygotesPrincipal Investigator
- Principal Investigator
  
  AKUTSU Hidenori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Research Institute for Child Health and Development
Basic study to explore molecular mechanism of the oocyte effecting on developmental potentialPrincipal Investigator
- Principal Investigator
  
  AKUTSU Hidenori
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Research Institute for Child Health and Development
ヒト胚性幹(ES)細胞を生かすことができるヒトフィーダー単離システムの創成
- Principal Investigator
  
  美留町潤一
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Human pathology
- Research Institution
  National Research Institute for Child Health and Development
Functional analysis of fusogenic factors related to infertility and its clinical application
- Principal Investigator
  
  MIYADO Kenji
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Research Institute for Child Health and Development
Study on a new assay for the function of mammalian spenn centrosome
- Principal Investigator
  
  ITO Chizuru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Chiba University
Genes expressed specifically in oocytes may have an important role in the quality (developmental competence) of oocytes
- Principal Investigator
  
  HAMATANI Toshio
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University
精子・卵の細胞接着の分子メカニズムと生殖医療への応用
- Principal Investigator
  
  宮戸健二
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  National Research Institute for Child Health and Development
Identification of human cardiomyogenic factor
- Principal Investigator
  
  UMEZAWA Akihiro
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  National Research Institute for Child Health and Development

[Journal Article] A single allele of the hsa-miR-302/367 cluster maintains human pluripotent stem cells2022
- Author(s)
  Sugawara Tohru、Kawamoto Yuki、Kawasaki Tomoyuki、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  Regenerative Therapy
  
  Volume: 21 Pages: 37-45
- DOI
  10.1016/j.reth.2022.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08906, KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-23K20315
[Journal Article] Familial Pseudohypoparathyroidism Type IB Associated with an SVA Retrotransposon Insertion in the GNAS Locus2022
- Author(s)
  Sayaka Kawashima, Akiko Yuno, Shinichiro Sano, Masayo Kagami
- Journal Title
  
  J Bone Miner Res .
  
  Volume: 10 Issue: 10 Pages: 1850-1859
- DOI
  10.1002/jbmr.4652
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08178, KAKENHI-PROJECT-21K07334, KAKENHI-PROJECT-22K07858, KAKENHI-PROJECT-20H00539, KAKENHI-PROJECT-20H03641, KAKENHI-PUBLICLY-21H00342, KAKENHI-PROJECT-23K24490
[Journal Article] Development of Human Gut Organoids With Resident Tissue Macrophages as a Model of Intestinal Immune Responses2022
- Author(s)
  Tsuruta Satoru、Kawasaki Tomoyuki、Machida Masakazu、Iwatsuki Ken、Inaba Akihiko、Shibata Shinsuke、Shindo Tomoko、Nakabayashi Kazuhiko、Hakamada Kenichi、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 14 Issue: 3 Pages: 726-729
- DOI
  10.1016/j.jcmgh.2022.06.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08906, KAKENHI-PROJECT-22K16477, KAKENHI-PROJECT-21K07764, KAKENHI-PROJECT-23K24490
[Journal Article] Xenogeneic-Free Human Intestinal Organoids for Assessing Intestinal Nutrient Absorption2022
- Author(s)
  Inoue Makoto、Tanaka Yuichi、Matsushita Sakiko、Shimozaki Yuri、Ayame Hirohito、Akutsu Hidenori
- Journal Title
  
  Nutrients
  
  Volume: 14 Issue: 3 Pages: 438-438
- DOI
  10.3390/nu14030438
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-20H00550
[Journal Article] Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions2022
- Author(s)
  Morita Kazuki、Nakamura Akihiro、Machida Masakazu、Kawasaki Tomoyuki、Nakanishi Rina、Ichida Justin、Iwata Takanori、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  Regenerative Therapy
  
  Volume: 21 Pages: 389-397
- DOI
  10.1016/j.reth.2022.09.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08906, KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-22KJ1198, KAKENHI-PROJECT-20K21670, KAKENHI-PROJECT-23K24531
[Journal Article] Reduced Replication Efficacy of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant in “Mini-gut” Organoids2022
- Author(s)
  Miyakawa Kei、Machida Masakazu、Kawasaki Tomoyuki、Nishi Mayuko、Akutsu Hidenori、Ryo Akihide
- Journal Title
  
  Gastroenterology
  
  Volume: 163 Issue: 2 Pages: 514-516
- DOI
  10.1053/j.gastro.2022.04.043
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08906
[Journal Article] De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs2022
- Author(s)
  Motosugi Nami、Sugiyama Akiko、Okada Chisa、Otomo Asako、Umezawa Akihiro、Akutsu Hidenori、Hadano Shinji、Fukuda Atsushi
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 12 Pages: 100352-100352
- DOI
  10.1016/j.crmeth.2022.100352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09555, KAKENHI-PROJECT-22K19409, KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-19H03551, KAKENHI-PROJECT-20H03829
[Journal Article] De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells2021
- Author(s)
  Fukuda Atsushi、Hazelbaker Dane Z.、Motosugi Nami、Hao Jin、Limone Francesco、Beccard Amanda、Mazzucato Patrizia、Messana Angelica、Okada Chisa、San Juan Irune Guerra、Qian Menglu、Umezawa Akihiro、Akutsu Hidenori、Barrett Lindy E.、Eggan Kevin
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 9 Pages: 2138-2148
- DOI
  10.1016/j.stemcr.2021.07.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-20H03829
[Journal Article] Identification of an epigenetic signature in human induced pluripotent stem cells using a linear machine learning model.2021
- Author(s)
  Nishino K, Takasawa K, Okamura K, Arai Y, Sekiya A, Akutsu H, Umezawa A.
- Journal Title
  
  Hum Cell
  
  Volume: 34 Issue: 1 Pages: 99-110
- DOI
  10.1007/s13577-020-00446-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-21K06143
[Journal Article] Human Pluripotent Stem Cell-Derived Organoids as a Model of Intestinal Xenobiotic Metabolism2021
- Author(s)
  Sasaki Kengo、Inoue Makoto、Machida Masakazu、Kawasaki Tomoyuki、Tsuruta Satoru、Uchida Hajime、Sakamoto Seisuke、Kasahara Mureo、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  StemJournal
  
  Volume: 3 Issue: 1 Pages: 1-10
- DOI
  10.3233/stj-200001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-19K18106, KAKENHI-PROJECT-19K18167, KAKENHI-PROJECT-18K15696
[Journal Article] Deletion of lncRNA XACT does not change expression dosage of X-linked genes, but affects differentiation potential in hPSCs2021
- Author(s)
  Motosugi Nami、Okada Chisa、Sugiyama Akiko、Kawasaki Tomoyuki、Kimura Minoru、Shiina Takashi、Umezawa Akihiro、Akutsu Hidenori、Fukuda Atsushi
- Journal Title
  
  Cell Reports
  
  Volume: 35 Issue: 10 Pages: 109222-109222
- DOI
  10.1016/j.celrep.2021.109222
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00550
[Journal Article] The hsa-miR-302 cluster controls ectodermal differentiation of human pluripotent stem cell via repression of DAZAP22020
- Author(s)
  Sugawara T, Miura T, Kawasaki T, Umezawa A, Akutsu H.
- Journal Title
  
  Regen Ther
  
  Volume: 15 Pages: 1-9
- DOI
  10.1016/j.reth.2020.03.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17K01443, KAKENHI-PROJECT-18K08666
[Journal Article] Mitochondrial Genetic Drift after Nuclear Transfer in Oocytes.2020
- Author(s)
  Yamada M, Akashi K, Ooka R, Miyado K, Akutsu H.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16:21(16) Issue: 16 Pages: 5880-5880
- DOI
  10.3390/ijms21165880
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09787, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-20H00550, KAKENHI-PROJECT-23K20330
[Journal Article] Transcriptomic features of trophoblast lineage cells derived from human induced pluripotent stem cells treated with BMP 42020
- Author(s)
  Tsuchida Nanae、Kojima Junya、Fukuda Atsushi、Oda Mayumi、Kawasaki Tomoyuki、Ito Hiroe、Kuji Naoaki、Isaka Keiichi、Nishi Hirotaka、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  Placenta
  
  Volume: 89 Pages: 20-32
- DOI
  10.1016/j.placenta.2019.10.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08085, KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-18K16816, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-17K16880
[Journal Article] Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality2020
- Author(s)
  Mitsutoshi Yamada, Suguru Sato, Reina Ooka, Kazuhiro Akashi, Akihiro Nakamura, Kenji Miyado, Hidenori Akutsu, Mamoru Tanaka
- Journal Title
  
  Reproductive Medicine and Biology
  
  Volume: 20 Pages: 53-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K20330
[Journal Article] Mitochondrial replacement by genome transfer in human oocytes: Efficacy, concerns, and legality.2020
- Author(s)
  Yamada M, Sato S, Ooka R, Akashi K, Nakamura A, Miyado K, Akutsu H, Tanaka M.
- Journal Title
  
  Reprod Med Biol.
  
  Volume: 3:20(1) Issue: 1 Pages: 53-61
- DOI
  10.1002/rmb2.12356
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09787, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-20H00550
[Journal Article] Odf2 haploinsufficiency causes a new type of decapitated and decaudated spermatozoa, Odf2-DDS, in mice.2019
- Author(s)
  Ito C, Akutsu H, Yao R, Yoshida K, Yamatoya K, Mutoh T, Makino T, Aoyama K, Ishikawa H, Kunimoto K, Tsukita S, Noda T, Kikkawa M, Toshimori K.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 14249-14249
- DOI
  10.1038/s41598-019-50516-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09665, KAKENHI-PROJECT-19K22570, KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17K16850, KAKENHI-PLANNED-17H06333, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-18H03999, KAKENHI-PROJECT-18H02684, KAKENHI-PROJECT-19H05468
[Journal Article] Imprinted X‐chromosome inactivation impacts primitive endoderm differentiation in mouse blastocysts2019
- Author(s)
  Fukuda Atsushi、Motosugi Nami、Ando Mikiko、Kimura Minoru、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  FEBS Letters
  
  Volume: 594 Issue: 5 Pages: 913-923
- DOI
  10.1002/1873-3468.13676
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17H01588
[Journal Article] Enhancement of Cellular Adhesion and Proliferation in Human Mesenchymal Stromal Cells by the Direct Addition of Recombinant Collagen I Peptide to the Culture Medium2019
- Author(s)
  Muraya Koji、Kawasaki Tomoyuki、Yamamoto Takeshi、Akutsu Hidenori
- Journal Title
  
  BioResearch Open Access
  
  Volume: 8 Issue: 1 Pages: 210-218
- DOI
  10.1089/biores.2019.0012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-17K16880
[Journal Article] Zscan5b Deficiency Impairs DNA Damage Response and Causes Chromosomal Aberrations during Mitosis.2019
- Author(s)
  Ogawa S, Yamada M, Nakamura A, Sugawara T, Nakamura A, Miyajima S, Harada Y, Ooka R, Okawa R, Miyauchi J, Tsumura H, Yoshimura Y, Miyado K, Akutsu H, Tanaka M, Umezawa A, Hamatani T.
- Journal Title
  
  Stem Cell Reports
  
  Volume: 12 Issue: 6 Pages: 1366-1379
- DOI
  10.1016/j.stemcr.2019.05.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08666, KAKENHI-PROJECT-19K22602, KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-19H01067, KAKENHI-PROJECT-16H05475, KAKENHI-PROJECT-17H04236, KAKENHI-PROJECT-17H05100
[Journal Article] Aneuploid rescue precedes X-chromosome inactivation and increases the incidence of its skewness by reducing the size of the embryonic progenitor cell pool.2019
- Author(s)
  Yoshida T, Miyado M, Mikami M, Suzuki E, Kinjo K, Matsubara K, Ogata T, Akutsu H, Kagami M and Fukami M.
- Journal Title
  
  Human Reproduction
  
  Volume: 34 Issue: 9 Pages: 1762-1769
- DOI
  10.1093/humrep/dez117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09682, KAKENHI-PROJECT-19K22988, KAKENHI-PLANNED-17H06428, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-17H04204
[Journal Article] Exploring trophoblast-specific Tead4 enhancers through chromatin conformation capture assays followed by functional screening2019
- Author(s)
  Tomikawa Junko、Takada Shuji、Okamura Kohji、Terao Miho、Ogata-Kawata Hiroko、Akutsu Hidenori、Tanaka Satoshi、Hata Kenichiro、Nakabayashi Kazuhiko
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 48 Issue: 1 Pages: 278-289
- DOI
  10.1093/nar/gkz1034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08689, KAKENHI-PROJECT-19K22988, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-17K07248, KAKENHI-PROJECT-18H03556
[Journal Article] Autonomous trisomic rescue of Down syndrome cells2019
- Author(s)
  Inoue Momoko、Kajiwara Kazuhiro、Yamaguchi Ayumi、Kiyono Tohru、Samura Osamu、Akutsu Hidenori、Sago Haruhiko、Okamoto Aikou、Umezawa Akihiro
- Journal Title
  
  Laboratory Investigation
  
  Volume: Feb 13 Issue: 6 Pages: 1-12
- DOI
  10.1038/s41374-019-0230-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-15K19665
[Journal Article] Manipulation of Xist Imprinting in Mouse Preimplantation Embryos2018
- Author(s)
  Fukuda Atsushi、Umezawa Akihiro、Akutsu Hidenori
- Journal Title
  
  Methods in Molecular Biology
  
  Volume: 1861 Pages: 47-53
- DOI
  10.1007/978-1-4939-8766-5_4
- ISBN
  9781493987658, 9781493987665
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-16K15716
[Journal Article] Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors2018
- Author(s)
  Nishino Koichiro、Arai Yoshikazu、Takasawa Ken、Toyoda Masashi、Yamazaki-Inoue Mayu、Sugawara Tohru、Akutsu Hidenori、Nishimura Ken、Ohtaka Manami、Nakanishi Mahito、Umezawa Akihiro
- Journal Title
  
  Regenerative Therapy
  
  Volume: 9 Pages: 71-78
- DOI
  10.1016/j.reth.2018.08.002
- NAID
  120007128469
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-15H04715, KAKENHI-PROJECT-16K15716
[Journal Article] A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells2017
- Author(s)
  2.Uchida H, Machida M, Miura T, Kawasaki T, Okazaki T, Sasaki K, Sakamoto S, Ohuchi N, Kasahara M, Umezawa A, Akutsu H.
- Journal Title
  
  Journal of Clinical Investigation Insight
  
  Volume: 2 Issue: 1
- DOI
  10.1172/jci.insight.86492
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462582, KAKENHI-PROJECT-16K19907, KAKENHI-PROJECT-16K21668
[Journal Article] DNA hypermethylation enhanced telomerase reverse transcriptase expression in human-induced pluripotent stem cells.2017
- Author(s)
  Takasawa K, Arai Y, Yamazaki-Inoue M, Toyoda M, Akutsu H, Umezawa A, Nishino K.
- Journal Title
  
  Human Cell
  
  Volume: 31 Issue: 1 Pages: 78-86
- DOI
  10.1007/s13577-017-0190-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-15J11596, KAKENHI-PROJECT-16K15055, KAKENHI-PROJECT-16K16193
[Journal Article] Method for evaluation of human induced pluripotent stem cell quality using image analysis based on the biological morphology of cells.2017
- Author(s)
  Wakui T, Matsumoto T, Matsubara K, Kawasaki T, Yamaguchi H, Akutsu H.
- Journal Title
  
  J Med Imaging (Bellingham)
  
  Volume: 4 Issue: 04 Pages: 044003-044003
- DOI
  10.1117/1.jmi.4.4.044003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15716
[Journal Article] The serine 106 residue within the N-terminal transactivation domain is crucial for Oct4 function in mice2017
- Author(s)
  Mitani A, Fukuda A, Miyashita T, Umezawa A, Akutsu H
- Journal Title
  
  zygote
  
  Volume: 25 Issue: 2 Pages: 197-204
- DOI
  10.1017/s0967199417000053
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15716, KAKENHI-PROJECT-17K10061, KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-15K09729
[Journal Article] Spatiotemporal dynamics of OCT4 protein localization during preimplantation development in mice2016
- Author(s)
  Fukuda A, Mitani A, Miyashita T, Kobayashi H, Umezawa A, Akutsu H
- Journal Title
  
  Reproduction
  
  Volume: 152 Issue: 5 Pages: 417-30
- DOI
  10.1530/rep-16-0277
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05579, KAKENHI-PROJECT-26293364, KAKENHI-PROJECT-26861350, KAKENHI-PROJECT-16K15716
[Journal Article] Maintenance of Xist imprinting depends on chromatin condensation state and Rnf12 dosage in mice.2016
- Author(s)
  Fukuda, A., Mitani, A., Miyashita, T., Sado, T., Umezawa, A., and *Akutsu, H.
- Journal Title
  
  PloS Genet.
  
  Volume: 12(10) Issue: 10 Pages: e1006375-e1006375
- DOI
  10.1371/journal.pgen.1006375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01320, KAKENHI-PROJECT-26293364, KAKENHI-PROJECT-26861350, KAKENHI-PROJECT-16K15716
[Journal Article] Towards further optimization of preimplantation embryo culture media: From the viewpoint of somatic cell nuclear transfer (SCNT) and omics studies2016
- Author(s)
  Mitsutoshi Yamada, Toshio Hamatani, Hidenori Akutsu, Mamoru Tanaka
- Journal Title
  
  Journal of Mammalian Ova Research
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293345
[Journal Article] Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes2015
- Author(s)
  Atsushi Fukuda, Motohiko Tanino, Ryo Matoba, Akihiro Umezawa, Hidenori Akutsu
- Journal Title
  
  Scientific reports
  
  Volume: 5 Issue: 1 Pages: 14101-14101
- DOI
  10.1038/srep14101
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861350, KAKENHI-PROJECT-25670710, KAKENHI-PROJECT-26293364
[Journal Article] Notch inhibition allows oncogene-independent generation of iPS cells2015
- Author(s)
  Ichida JK, T C W J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K
- Journal Title
  
  Nature Chemical Biology
  
  Volume: 1 Issue: 8 Pages: 632-639
- DOI
  10.1038/nchembio.1552
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670710, KAKENHI-PROJECT-25670741, KAKENHI-PROJECT-26293364
[Journal Article] Xenogeneic-free defined conditions for derivation and expansion of human embryonic stem cells with mesenchymal stem cells.2015
- Author(s)
  2.Akutsu H, Machida M, Kanzaki S, Sugawara T, Ohkura T, Nakamura N, Yamazaki-Inoue M, Miura T, Vemuri MC, Rao MS, Miyado K, Umezawa A.
- Journal Title
  
  Regenerative Therapy
  
  Volume: 1 Pages: 18-29
- DOI
  10.1016/j.reth.2014.12.004
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462582, KAKENHI-PROJECT-26293364
[Journal Article] Chromatin condensation of Xist genomic loci during oogenesis in mice2015
- Author(s)
  Fukuda, A., Mitani, A., Miyashita, T., Umezawa, A., Akutsu, H
- Journal Title
  
  Development
  
  Volume: 142 Pages: 4049-4055
- DOI
  10.1242/dev.127308
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09729, KAKENHI-PROJECT-26461530, KAKENHI-PROJECT-26861350, KAKENHI-PROJECT-25670710, KAKENHI-PROJECT-26293364
[Journal Article] Generation of primitive neural stem cells from human fibroblasts using a defined set of factors.2015
- Author(s)
  3.Miura T, Sugawara T, Fukuda A, Machida M, Tamoto R, Kawasaki T, Umezawa A, Akutsu H.
- Journal Title
  
  Biology Open
  
  Volume: 4 Issue: 11 Pages: 1595-1607
- DOI
  10.1242/bio.013151
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25462582, KAKENHI-PROJECT-25670710, KAKENHI-PROJECT-26293364
[Journal Article] Ethical acceptability of research on human-animal chimeric embryos: summary of opinions by the Japanese Expert Panel on Bioethics2015
- Author(s)
  Mizuno H, Akutsu H, Kato K
- Journal Title
  
  Life Sci Soc Policy.
  
  Volume: 11 Issue: 1 Pages: 15-15
- DOI
  10.1186/s40504-015-0033-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670710, KAKENHI-PROJECT-26293364
[Journal Article] The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice.2014
- Author(s)
  Fukuda A, Tomikawa J, Miura T, Hata K, Nakabayashi K, Eggan K, Akutsu H, Umezawa A.
- Journal Title
  
  Nat Commun.
  
  Volume: 5 Issue: 1 Pages: 5464-5464
- DOI
  10.1038/ncomms6464
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460409, KAKENHI-PROJECT-25670710, KAKENHI-PROJECT-25860259, KAKENHI-PROJECT-26293364, KAKENHI-PROJECT-26861350
[Journal Article] 【生殖再生医学】ヒトクローンES細胞の樹立2014
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 福永朝子, 吉村泰典
- Journal Title
  
  HORMONE FRONTIER IN GYNECOLOGY
  
  Volume: 21(2) Pages: 117-120
- Data Source
  KAKENHI-PROJECT-25293345
[Journal Article] ヒトES/iPS細胞と生殖補助医療2014
- Author(s)
  阿久津英憲
- Journal Title
  
  産科と婦人科
  
  Volume: 3 Pages: 295-302
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Derivation of human decidua-like cells from amnion and menstrual blood2014
- Author(s)
  Sugawara K, Hamatani T, Yamada M, Ogawa S, Kamijo S, Kuji N, Akutsu H, Miyado K, Yoshimura Y, Umezawa A
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 4599-4599
- DOI
  10.1038/srep04599
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-23592413, KAKENHI-PROJECT-23659788, KAKENHI-PROJECT-25293345, KAKENHI-PROJECT-25861518, KAKENHI-PROJECT-26293363, KAKENHI-PROJECT-26670733
[Journal Article] ES細胞-その基礎と臨床応用に向けた展望-2013
- Author(s)
  阿久津英憲
- Journal Title
  
  整形・災害外科（再生医療の現況と最前線）
  
  Volume: 56 Pages: 501-506
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Stability of genomic imprinting in human induced pluripotent stem cells.2013
- Author(s)
  Hiura H, Toyoda M, Okae H, Sakurai M, Miyauchi N, Sato A, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Nishino K, Umezawa A, Arima T.
- Journal Title
  
  BMC Genet.
  
  Volume: 14(1) Pages: 32-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Age-associated telomere shortening in mouse oocytes2013
- Author(s)
  Yamada-Fukunaga T, Yamada M, Hamatani T, Chikazawa N, Ogawa S, Akutsu H, Miura T, Miyado K, Tarín JJ, Kuji N, Umezawa A, Yoshimura Y
- Journal Title
  
  Reprod Biol Endocrinol
  
  Volume: 11 Pages: 108-108
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN.2013
- Author(s)
  Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T, Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J.
- Journal Title
  
  Stem Cells Transl Med
  
  Volume: 2(4) Pages: 265-73
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells2013
- Author(s)
  Okumura N, Akutsu H, Sugawara T, Miura T, Takezawa Y, Hosoda A, Yoshida K, Ichida JK, Yamada M, Hamatani T, Kuji N, Miyado K, Yoshimura Y, Umezawa A
- Journal Title
  
  PLoS One
  
  Volume: 8(5) Issue: 5 Pages: 63265-63265
- DOI
  10.1371/journal.pone.0063265
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-21390456, KAKENHI-PROJECT-23592413, KAKENHI-PROJECT-23659788, KAKENHI-PROJECT-25293345, KAKENHI-PROJECT-25462582
[Journal Article] β-Catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells.2013
- Author(s)
  Okumura N, Akutsu H, Sugawara T, Miura T, Takezawa Y, Hosoda A, Yoshida K, Ichida JK, Yamada M, Hamatani T, Kuji N, Miyado K, Yoshimura Y, Umezawa A.
- Journal Title
  
  Plos One
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] β-Catenin Functions Pleiotropically in Differentiation and Tumorigenesis in Mouse Embryo-Derived Stem Cells2013
- Author(s)
  Okumura N, Akutsu H, Sugawara T, Miura T, Takezawa Y, Hosoda A, Yoshida K, Ichida JK, Yamada M, Hamatani T, Kuji N, Miyado K, Yoshimura Y, Umezawa A
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Age-associated telomere shortening in mouse oocytes2013
- Author(s)
  Yamada-Fukunaga T, Yamada M, Hamatani T, Chikazawa N, Ogawa S, Akutsu H, Miura T, Miyado K, Tarin JJ, Kuji N, Umezawa A, Yoshimura Y
- Journal Title
  
  Reprod Biol Endocrinol
  
  Volume: 11 Issue: 1 Pages: 108-108
- DOI
  10.1186/1477-7827-11-108
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-21390456, KAKENHI-PROJECT-23592413, KAKENHI-PROJECT-23659788, KAKENHI-PROJECT-25293345, KAKENHI-PROJECT-25462582
[Journal Article] A medium-chain fatty acid as an alternative energy source in mouse preimplantation development2012
- Author(s)
  Yamada M, Takanashi K, Hamatani T, Hirayama A, Akutsu H, Fukunaga T, Ogawa S, Sugawara K, Shinoda K, Soga T, Umezawa A, Kuji N, Yoshimura Y, Tomita M
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Pages: 980-980
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] クローン技術を応用するヒトES細胞の可能性2012
- Author(s)
  阿久津英憲,梅澤明弘
- Journal Title
  
  母子保健情報
  
  Volume: 66 Pages: 80-84
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] 生殖細胞の分化誘導2012
- Author(s)
  阿久津英憲, 福田篤
- Journal Title
  
  Medical Science Digest
  
  Volume: 38(6) Pages: 253-256
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] A medium-chain fatty acid as an alternative energy source in mouse preimplantation development.2012
- Author(s)
  Yamada M, Takanashi K, Hamatani T, Hirayama A, Akutsu H, Fukunaga T, Ogawa S, Sugawara K, Soga T, Umezawa T, Kuji N, Yoshimura Y, Tomita M.
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Pages: 930-930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer.2012
- Author(s)
  Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, Yuo A, Kubota K, Saito M, Saeki K.
- Journal Title
  
  Cell Metab
  
  Volume: 16(3) Pages: 394-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] A medium-chain fatty acid as an alternative energy source in mouse preimplantation development.2012
- Author(s)
  Yamada M, Takanashi K, Hamatani T, Hirayama A, Akutsu H, Fukunaga T, Ogawa S, Sugawara K, Shinoda K, Soga T, Umezawa A, Kuji N, Yoshimura Y, Tomita M
- Journal Title
  
  Sci Rep
  
  Volume: 2 Pages: 930-930
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells2012
- Author(s)
  Sugawara T, Nishino K, Umezawa A, Akutsu H
- Journal Title
  
  Stem Cell Res Ther
  
  Volume: 3 Pages: 8-8
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells.2012
- Author(s)
  Sugawara T, Nishino K, Umezawa A, Akutsu H
- Journal Title
  
  Stem Cell Res Ther
  
  Volume: 3 Pages: 8-8
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] クローン胚からのES細胞作製2012
- Author(s)
  阿久津英憲
- Journal Title
  
  実験医学
  
  Volume: 30 Pages: 1621-1625
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] クローン胚からのES細胞作製2012
- Author(s)
  阿久津英憲, 福田篤, Dieter Egli
- Journal Title
  
  実験医学
  
  Volume: 30(10) Pages: 253-256
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] Investigating cellular identity and manipulating cell fate using induced pluripotent stem cells.2012
- Author(s)
  Sugawara T, Nishino K, Umezawa A, Akutsu H.
- Journal Title
  
  Stem Cell Res Ther.
  
  Volume: 3(2) Pages: 8-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion.2011
- Author(s)
  Takezawa Y, Yoshida K, Miyado K, Sato M, Nakamura A, Kawano N, Sakakibara K, Kondo T, Harada Y, Ohnami N, Kanai S, Miyado M, Saito H, Takahashi Y, Akutsu H, Umezawa A.
- Journal Title
  
  Sci Rep
  
  Volume: 1 Pages: 68-68
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Early senescence is not an inevitable fate of human-induced pluripotent stem-derived cells.2011
- Author(s)
  Gokoh M, Nishio M, Nakamura N, Matsuyama S, Nakahara M, Suzuki S, Mitsumoto M, Akutsu H, Umezawa A, Yasuda K, Yuo A, Saeki K.
- Journal Title
  
  Cell Reprogram.
  
  Volume: 13(4) Pages: 361-70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] DNA methylation dynamics in human induced pluripotent stem cells over time.2011
- Author(s)
  Nishino K, Toyoda M, Yamazaki-Inoue M, Fukawatase Y, Chikazawa E, Sakaguchi H, Akutsu H, Umezawa A.
- Journal Title
  
  PLoS Genet.
  
  Volume: 7(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Lectin microarray analysis of pluripotent and multipotent stem cells.2011
- Author(s)
  Toyoda M, Yamazaki-Inoue M, Itakura Y, Kuno A, Ogawa T, Yamada M, Akutsu H, Takahashi Y, Kanzaki S, Narimatsu H, Hirabayashi J, Umezawa A.
- Journal Title
  
  Genes Cells.
  
  Volume: 16(1) Pages: 1-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] DNA methylation dynamics in human induced pluripotent stem cells over time2011
- Author(s)
  Nishino K, et al
- Journal Title
  
  PLoS Genetics
  
  Volume: 7 Issue: 5 Pages: e1002085-e1002085
- DOI
  10.1371/journal.pgen.1002085
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790372, KAKENHI-PROJECT-22390312
[Journal Article] Aging of the Female Reproductive System2011
- Author(s)
  Egli D, Akutsu H
- Journal Title
  
  J Mamm Ova Res
  
  Volume: 28 Pages: 118-125
- NAID
  10029898437
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Early senescence is not an inevitable fate of human induced pluripotent stem-derived cells2011
- Author(s)
  Gokoh M, Nakamura N, Matsuyama S, Nishio M, Akutsu H, Umezawa A, Yasuda K, Yuo A, Saeki K
- Journal Title
  
  Cellular Reprogram
  
  Volume: 13 Issue: 4 Pages: 361-370
- DOI
  10.1089/cell.2011.0004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591255, KAKENHI-PROJECT-22390312, KAKENHI-PROJECT-22591053
[Journal Article] β-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion2011
- Author(s)
  Takezawa Y, Yoshida K, Miyado K, Sato M, Nakamura A, Kawano N, Sakakibara K, Kondo T, Harada Y, Ohnami N, Kanai S, Miyado M, Saito H, Takahashi Y, Akutsu H, Umezawa A
- Journal Title
  
  Sci Rep
  
  Volume: 1 Issue: 1 Pages: 68-68
- DOI
  10.1038/srep00068
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21112006, KAKENHI-PROJECT-22390312, KAKENHI-PROJECT-23659788
[Journal Article] Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in development of mouse preimplantation embryos at cleavage stage.2011
- Author(s)
  Sato B, Katagiri YU, Miyado K, Okino N, Ito M, Akutsu H, Okita H, Umezawa A, Fujimoto J, Toshimori K, Kiyokawa N.
- Journal Title
  
  BMC Dev Biol.
  
  Volume: 11 Pages: 22-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] ヒトES 細胞, iPS細胞」生命の誕生に向けて(第二版)編集2011
- Author(s)
  阿久津英憲, 佐藤星子
- Journal Title
  
  日本哺乳類動物卵子学会
  
  Pages: 268-272
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] A distinct role for Pin1 in the induction and maintenance of pluripotency.2011
- Author(s)
  Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A.
- Journal Title
  
  J Biol Chem.
  
  Volume: 286(13) Pages: 11593-603
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] ARTによる出生時の問題児のエピジェネティックス異常との関連2011
- Author(s)
  阿久津英憲, 佐藤俊, 秦健一郎
- Journal Title
  
  臨床婦人科産科
  
  Volume: 65 Pages: 770-776
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Beta-catenin is a molecular switch that regulates transition of cell-cell adhesion to fusion2011
- Author(s)
  Takezawa Y, Yoshida K, Miyado K, Sato M, Nakamura A, Kawano N, Sakakibara K, Kondo T, Harada Y, Ohnami N, Kanai S, Miyado M, Saito H, Takahashi Y, Akutsu H, Umezawa A
- Journal Title
  
  Scientific Reports
  
  Volume: 1 Pages: 68-68
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Aging of the Female Reproductive System.2011
- Author(s)
  Egli D, Akutsu H
- Journal Title
  
  J Mamm Ova Res
  
  Volume: 28 Pages: 118-125
- NAID
  10029898437
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] Efficient generation of hepatoblasts from human ES cells and iPS cells by transient overexpression of homeobox gene HEX.2011
- Author(s)
  Inamura M, Kawabata K, Takayama K, Tashiro K, Sakurai F, Katayama K, Toyoda M, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Umezawa A, Hayakawa T,Furue MK, Mizuguchi H.
- Journal Title
  
  Mol Ther.
  
  Volume: 19(2) Pages: 400-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Lipid rafts enriched in monosialylGb5Cer carrying the stage-specific embryonic antigen-4 epitope are involved in development of mouse preimplantation embryos at cleavage stage.2011
- Author(s)
  Sato B, Katagiri YU, Miyado K, Okino N, Ito M, Akutsu H, Okita H, Umezawa A, Fujimoto J, Toshimori K, Kiyokawa N.
- Journal Title
  
  BMC Dev Biol.
  
  Pages: 11-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.2010
- Author(s)
  Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K.
- Journal Title
  
  Nature
  
  Volume: 465 Pages: 175-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.2010
- Author(s)
  Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K.
- Journal Title
  
  Nature
  
  Volume: 465 Pages: 175-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.2010
- Author(s)
  Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K.
- Journal Title
  
  Nature
  
  Volume: 465(7295) Pages: 175-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] 良質精子の条件;精子頭部扁平化およびperinuclear theca構成物質MN13と関連する卵活性化能2010
- Author(s)
  伊藤千鶴、阿久津英憲、京野廣一、宇都宮隆史、年森清隆
- Journal Title
  
  産婦人科の実際
  
  Volume: 59 Pages: 2069-2075
- NAID
  40017379751
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] Defining hypo-methylated regions of stem cell-specific promoters in human iPS cells derived from extra-embryonic amnions and lung fibroblasts.2010
- Author(s)
  Nishino K, Toyoda M, Yamazaki-Inoue M, Makino H, Fukawatase Y, Chikazawa E, Takahashi Y, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A.
- Journal Title
  
  PLoS One
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659304
[Journal Article] Defining hypo-methylated regions of stem cell-specific promoters in human iPS cells derived from extra-embryonic amnions and lung fibroblasts.2010
- Author(s)
  Nishino K, Toyoda M, Yamazaki-Inoue M, Makino H, Fukawatase Y, Chikazawa E, Takahashi Y, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A.
- Journal Title
  
  PLoS One.
  
  Volume: 5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Defining hypo-methylated regions of stem cell-specific promoters in human iPS cells derived from extra-embryonic amnions and lung fibroblasts.2010
- Author(s)
  Nishino K, Toyoda M, Yamazaki-Inoue M, Makino H, Fukawatase Y, Chikazawa E, Takahashi Y, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A.
- Journal Title
  
  PLoS One
  
  Volume: 5(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development2010
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A
- Journal Title
  
  Human Molecular Genetics 19(3)
  
  Pages: 480-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591911
[Journal Article] Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells2010
- Author(s)
  Stadtfeld M, Apostolou E, Akutsu H, Fukuda A, Follett P, Natesan S, Kono T, Shioda T, Hochedlinger K
- Journal Title
  
  Nature
  
  Volume: 465 Pages: 175-181
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development2010
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A.
- Journal Title
  
  Human Molecular Genetics 19(3)
  
  Pages: 480-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591911
[Journal Article] Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development2010
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A
- Journal Title
  
  Hum Mol Genet
  
  Volume: 19 Pages: 480-493
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development.2010
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A.
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 19 Pages: 480-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Chemical inhibition of sulfation accelerates neural differentiation of mouse embryonic stem cells and human induced pluripotent stem cells.2010
- Author(s)
  Sasaki N, Hirano T, Kobayashi K, Toyoda M, Miyakawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Nishihara S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 401(3) Pages: 480-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390312
[Journal Article] Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD92009
- Author(s)
  Akutsu H, Miura T, Machida M, Birumachi JI, Hamada A, Yamada M, Sullivan S, Miyado K, Umezawa A
- Journal Title
  
  Differentiation
  
  Volume: 78 Pages: 137-142
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog2009
- Author(s)
  Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K.
- Journal Title
  
  Cell Stem Cell. 5
  
  Pages: 491-503
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Involvement of a novel preimplantation-specific gene encoding the high mobility group box protein Hmgpi in early embryonic development2009
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A
- Journal Title
  
  Hum Mol Genet 19
  
  Pages: 480-493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Fitz-Gerald F, Zhang K, Melton D, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines2009
- Author(s)
  Chen A, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Chad C
- Journal Title
  
  Cell Stem Cell
  
  Volume: 4 Pages: 103-106
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog2009
- Author(s)
  Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K
- Journal Title
  
  Cell Stem Cell
  
  Volume: 5 Pages: 491-503
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD92009
- Author(s)
  Akutsu H, Miura T, Machida M, Birumachi JI, Hamada A, Yamada M, Sullivan S, Miyado K, Umezawa A.
- Journal Title
  
  Differentiation 78(2-3)
  
  Pages: 137-42
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD9.2009
- Author(s)
  Akutsu H, Miura T, Machida M, Birumachi JI, Hamada A, Yamada M, Sullivan S, Miyado K, Umezawa A.
- Journal Title
  
  Differentiation 78(2-3)
  
  Pages: 137-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD92009
- Author(s)
  Akutsu H, Miura T, Machida M, Birumachi J, Hamada A, Yamada M, Sullivan S, Miyado K, Umezawa A.
- Journal Title
  
  Differentiation 78
  
  Pages: 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390456
[Journal Article] Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD92009
- Author(s)
  Akutsu H, Miura T, Machida M, Birumachi JI, Hamada A, Yamada M, Sullivan S, Miyado K, Umezawa A
- Journal Title
  
  Differentiation 78
  
  Pages: 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Maintenance of pluripotency and self-renewal ability of mouse embryonic stem cells in the absence of tetraspanin CD92009
- Author(s)
  Akutsu H, Miura T, Machida M, Birumachi JI, Hamada A, Yamada M, Sullivan S, Miyado K, Umezawa A
- Journal Title
  
  Differentiation 78
  
  Pages: 137-142
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659431
[Journal Article] Possible involvement of CD81 in acrosome reaction of sperm in mice.2008
- Author(s)
  Tanigawa M, Miyamoto K, Kobayashi S, Sato M, Akutsu H, Okabe M, Mekada E, Umezawa A, Miyado K.
- Journal Title
  
  Mol Reprod Dev(Miyado K is a corresponding author) 75(1)
  
  Pages: 150-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Possible involvement of CD81 in acrosome reaction of sperm in mice2008
- Author(s)
  Tanigawa M, Miyamoto K, Koba yashi S, Sato M, Akutsu H, Okabe M, Mekada E, Umezawa A, and Miyado K.
- Journal Title
  
  Molecular Reproduction md Development 75
  
  Pages: 150-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] The fusing ability of sperm is bestowed by CD-9containing vesicles released from eggs in mice2008
- Author(s)
  Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A.
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 12921-12926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591878
[Journal Article] Functional significance of stage-specific embryonic antigens in the development of preimplantation embryos.2008
- Author(s)
  Katagiri Y, Sato B, Miyado K, Akutsu H, Okita H, Umezawa A, Fujimoto J, Kiyokawa N.
- Journal Title
  
  Trends in Glycoscience and Glycotechnology 20(113)
  
  Pages: 131-39
- NAID
  10024322754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] What can you learn from gene expression profiling of mouse oocytes?2008
- Author(s)
  Hamatani T, Yamada M, Akutsu H, Kuji N, Mochimaru Y, Takano M, Toyoda M, Miyado M, Umezawa A, Kuji N, Yoshimura Y
- Journal Title
  
  Reproduction 135(5)
  
  Pages: 581-592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591911
[Journal Article] The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice.2008
- Author(s)
  Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A.
- Journal Title
  
  Proc Natl Acad Sci USA(Miyado K is a corresponding author; Faculty of 1000 Biology推薦論文) 105(35)
  
  Pages: 12921-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] What can you learn from gene expression profiling of mouse oocytes2008
- Author(s)
  Hamatani T, Yamada M, Akutsu H, Kuji N, Mochimaru Y, Takano M, Toyoda M, Miyado M, Umezawa A, Kuji N, Yoshimura Y.
- Journal Title
  
  Reproduction 135(5)
  
  Pages: 581-592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591911
[Journal Article] Possible involvement of CD81 in acrosome reaCtion of sperm in mice2008
- Author(s)
  Tanigawa M, Miyamaoto K, Kobayashi S, Sato M, Akutsu H, Okabe M, Mekada E, Umezawa A, and Mivado K.
- Journal Title
  
  Molecular Reproduction and Development 75
  
  Pages: 150-155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659431
[Journal Article] What can we learn from gene expression profiling of mouse oocytes?2008
- Author(s)
  Hamatani T, Yamada M, Akutsu H, Kuji N, Mochimaru Y, Takano M, Toyoda M, Miyado K, Umezawa A, Yoshimura Y.
- Journal Title
  
  Reproduction 135(5)
  
  Pages: 581-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice2008
- Author(s)
  Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A.
- Journal Title
  
  Proc Natl Acad Sci USA 105(35)
  
  Pages: 12921-6
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] What can you learn from gene expression profiling of mouse oocytes?2008
- Author(s)
  Hamatani T, Yamada M, Akutsu H, Kuji N, Mochimaru Y, Takano M, Toyoda M, Miyado M, Umezawa A, Kuji N, Yoshimura Y.
- Journal Title
  
  Reproduotion 135(5)
  
  Pages: 581-592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591911
[Journal Article] The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice2008
- Author(s)
  Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 12921-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659431
[Journal Article] The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice2008
- Author(s)
  Miyado K, Yoshida K, Yamagata K, Sakakibara K, Okabe M, Wang X, Miyamoto K, Akutsu H, Kondo T, Takahashi Y, Ban T, Ito C, Toshimori K, Nakamura A, Ito M, Miyado M, Mekada E, Umezawa A
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 12921-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] What can we learn from gene expression profiling of mouse oocytes?2008
- Author(s)
  Hamatani T, Yamada M, Akutsu H, Kuji N, Mochimaru Y, Takano M, Toyoda M, Miyado K, Umezawa A, Yoshimura Y
- Journal Title
  
  Reproduction 135
  
  Pages: 581-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] What can we learn from gene expression profiling of mouse oocytes?2008
- Author(s)
  Hamatani T, Yamada M, Akutsu H, Kuji N, Mochimaru Y, Takano M, Toyoda M, Miyado K, Umezawa A, Yoshimura Y
- Journal Title
  
  Reproduction 135
  
  Pages: 581-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659431
[Journal Article] Possible involvement of CD81 in acrosome reaction of sperm in mice2008
- Author(s)
  Tanigawa M, Miyamoto K, Kobayashi S, Sato M, Akutsu H, Okabe M, Mekada E, Umezawa A, Miyado K.
- Journal Title
  
  Mol Repro Dev 75
  
  Pages: 150-5
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Preferential localization of SSEA-4 in interfaces between blastomeres of mouse preimplantaion embryos.2007
- Author(s)
  Sato B, Katagiri YU, Miyado K, Akutsu H, Miyagawa Y, Horiuchi Y, Nakajima H, Okita H, Umezawa A, Hata J, Fujimoto J, Toshimori K, Kiyokawa N.
- Journal Title
  
  Biochem Biophys Res Commun 364(4)
  
  Pages: 838-43
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Preferential localization of SSEA-A in interfaces between blastomeres of mouse preimplantation embryos2007
- Author(s)
  Sato B, Katagiri Y-U, Miyado K, Akutsu H, Miyagawa Y, Horiuchi Y, Nakajima H, Okita H, Umezawa A, Hata J, Fujimoto J, Toshimori K, Kiyokawa N.
- Journal Title
  
  BBRC 364
  
  Pages: 838-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591878
[Journal Article] Preferential localization of SSEA-4 in interfaces between blastomeres of mouse preimplantaion embryos2007
- Author(s)
  Sato B, Katagiri YU, Miyado K, Akutsu H, Miyagawa Y, Horiuchi Y, Nakajima H, Okita H, Umezawa A, Hata J, Fujimoto J, Toshimori K, Kiyokawa N.
- Journal Title
  
  Biochem Biophys Res Commun 364(4)
  
  Pages: 838-43
- Data Source
  KAKENHI-PROJECT-19390431
[Journal Article] Preferential localization of SSEA-4 in interfaces between blastomeresof mouse preimplantaion embryos2007
- Author(s)
  Sato B, Katagiri YU, Miyado K, Akutsu H, Miyagawa Y, Horiuchi Y, Nakajima H, Okita H, Umezawa A, Hata J, Fujimoto J, To Shimori K, Kiyokawa N.
- Journal Title
  
  Biochem Biophys Res Comun 364
  
  Pages: 838-843
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390431
[Patent] iPS前駆細胞及びiPS細胞2013
- Inventor(s)
  三浦　巧、阿久津英憲、梅澤明弘
- Industrial Property Rights Holder
  ヒューマンサイエンス振興財団
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-082731
- Filing Date
  2013-04-11
- Data Source
  KAKENHI-PROJECT-25462582
[Patent] 哺乳動物卵内への細胞外物質の導入促進剤及び導入方法2010
- Inventor(s)
  阿久津英憲、宮戸真美、宮戸健二
- Industrial Property Rights Holder
  Japan Science and Technology Agency
- Acquisition Date
  2010-01-29
- Data Source
  KAKENHI-PROJECT-19390431
[Patent] Promoter for introducing extracellular substance into mammalian ovum and introduction method2010
- Inventor(s)
  阿久津英憲, 宮戸真美, 宮戸健二
- Industrial Property Rights Holder
  Japan Science and Technology Agency
- Acquisition Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-19390431
[Presentation] ヒト胚研究の現状と未来2023
- Author(s)
  阿久津英憲
- Organizer
  日本再生医療学会総会　市民公開講座
- Invited
- Data Source
  KAKENHI-PROJECT-20H00550
[Presentation] ヒト多能性幹細胞におけるX染色体不活性化の破綻2022
- Author(s)
  阿久津英憲
- Organizer
  第127回日本解剖学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00550
[Presentation] 受精から捉える成育医学研究の現在地、そしてその先2022
- Author(s)
  阿久津英憲
- Organizer
  第94回日本組織培養学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00550
[Presentation] 再生医療の医療倫理2022
- Author(s)
  阿久津英憲
- Organizer
  第67回日本生殖医学会学術講演会・総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00550
[Presentation] ヒト受精卵へのゲノム編集について理解しなければいけないこと2021
- Author(s)
  阿久津英憲
- Organizer
  第62回日本卵子学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00550
[Presentation] AGE-DEPENDENT CHARACTERISTICS OF TRANSCRIPTION AND METABOLISM IN PLURIPOTENT STEM CELLS2020
- Author(s)
  Reina Ooka, Mitsutoshi Yamada*, Akihiro Nakamura, Tohru Sugawara, Kohsuke Kanekura, Kenji Miyado, Hidenori Akutsu, Mamoru Tanaka, and Akihiro Umezawa (*correspondence to)
- Organizer
  ISSCR Annual meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20330
[Presentation] 受精と幹細胞が拓く次世代産婦人科研究の展望2020
- Author(s)
  阿久津英憲
- Organizer
  第72回日本産科婦人科学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-20H00550
[Presentation] ヒトES/iPS細胞を用いた機能的臓器（ミニ腸等）の創出2019
- Author(s)
  阿久津英憲
- Organizer
  日本補綴歯科学会第128回学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22988
[Presentation] ゲノム編集技術による研究と応用の課題2019
- Author(s)
  阿久津英憲
- Organizer
  第31回日本生命倫理学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] ゲノム編集の治療応用と倫理的課題2019
- Author(s)
  阿久津英憲
- Organizer
  第81回日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] ゲノム編集技術のヒト受精卵への応用～ARTに携わる人が考えなければならないこととは～2019
- Author(s)
  阿久津英憲
- Organizer
  第25回日本臨床エンブリオロジスト学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] ゲノム編集技術による研究と応用の課題2019
- Author(s)
  阿久津英憲
- Organizer
  第 31 回日本生命倫理学会年次大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K22988
[Presentation] ゲノム編集技術を応用したヒト受精胚研究について2019
- Author(s)
  阿久津英憲
- Organizer
  第37回日本受精着床学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] ゲノム編集技術を応用したヒト受精胚研究について2019
- Author(s)
  阿久津英憲
- Organizer
  第122回日本小児科学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] Zfp371 is a novel DNA repair gene responsible for genome stability during mitosis2019
- Author(s)
  Seiji Ogawa, Mitsutoshi Yamada, Toshio Hamatani, Hidenori Akutsu, Akihiro Umezawa, Mamoru Tanaka, Daisuke Aoki
- Organizer
  The 70th Annual Congress of the Japan Society of Obstetrics and Gynecology
- Data Source
  KAKENHI-PROJECT-16H05475
[Presentation] ヒト受精卵とゲノム編集研究：臨床利用は有りか無しか2019
- Author(s)
  阿久津英憲
- Organizer
  第 64 回日本生殖医学学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] 次世代臓器オルガノイド「ミニ腸」を使った創薬支援2019
- Author(s)
  阿久津英憲
- Organizer
  第1回再生医療産業化展
- Invited
- Data Source
  KAKENHI-PROJECT-19K22988
[Presentation] ヒト ES細胞の臨床応用2018
- Author(s)
  阿久津英憲
- Organizer
  第59回日本卵子学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] Zfp371 is a novel DNA repair gene responsible for genome stability during mitosis.2018
- Author(s)
  Seiji Ogawa, Mitsutoshi Yamada, Toshio Hamatani, Hidenori Akutsu, Akihiro Umezawa, Mamoru Tanaka, Daisuke Aoki.
- Organizer
  The 70th Annual Congress of the Japan Society of Obstetrics and Gynecology, SENDAI INTERNATIONAL CENTER, May 12, 2018.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05475
[Presentation] Regulatory Actions for　Researches Using Genome Editing Technology on Human Embryos in Japan2018
- Author(s)
  Hidenori Akutsu
- Organizer
  Second International Summit on Human Genome Editing
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01588
[Presentation] 雌性胚の受精卵から個体発生に至るクロマチン制御機構2017
- Author(s)
  阿久津英憲
- Organizer
  日本生殖再生医学会　第12回学術集会
- Place of Presentation
  東京シェーンバッハサボ－
- Invited
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] 胚性遺伝子KzpiはDifferentially methylated regionsにおけるメチル化を保護して胚発生に寄与する．2017
- Author(s)
  上條慎太郎, 浜谷敏生, 山田満稔, 小川誠司, 阿久津英憲, 秦健一郎, 田中守, 青木大輔
- Organizer
  第69回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-16H05475
[Presentation] 多角的ゲノム解析からみる卵子の質評価の可能性2016
- Author(s)
  阿久津英憲
- Organizer
  第57回日本卵子学会
- Place of Presentation
  新潟コンベンションセンター
- Year and Date
  2016-05-14
- Invited
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] 多角的ゲノム解析からみる卵子の質評価の可能性2016
- Author(s)
  阿久津英憲
- Organizer
  第57回日本卵子学会
- Place of Presentation
  新潟コンベンションセンター
- Year and Date
  2016-05-14
- Invited
- Data Source
  KAKENHI-PROJECT-16K15716
[Presentation] ES細胞、iPS細胞等を用いる神経難病児者への治療法開発の展望2015
- Author(s)
  阿久津英憲
- Organizer
  第二十回日本難病看護学会学術集会
- Place of Presentation
  東京
- Year and Date
  2015-07-24
- Invited
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] The role of asymmetric histone modifications in embryo development2015
- Author(s)
  Akutsu, Hidenori
- Organizer
  IFFS/JSRM International Meeting 2015
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2015-04-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] 着床前期胚培養における脂肪酸の有用性2015
- Author(s)
  若松修平，浜谷敏生，山田満稔，阿久津英憲，佐々木拓之，竹本崇史，戸田里実，山田朝子，小川誠司，小田原靖，田中守，青木大輔
- Organizer
  第67回日本産科婦人科学会学術講演会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-04-10
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] The role of asymmetric histone modifications in embryo development2015
- Author(s)
  Akutsu, Hidenori
- Organizer
  IFFS/JSRM International Meeting 2015
- Place of Presentation
  Yokohama, Japan
- Year and Date
  2015-04-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670710
[Presentation] ヒトES細胞2014
- Author(s)
  阿久津英憲
- Organizer
  第26回日本生命倫理学会年次大会
- Place of Presentation
  浜松
- Year and Date
  2014-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] Beta catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells (poster) T-23752013
- Author(s)
  Akutsu H, Sugawara T, Takezawa Y, Kawasaki T, Okumura N, Miura T, Miyado K, Umezawa A
- Organizer
  11th ISSCR 2013 Annual Meeting
- Place of Presentation
  Boston, MA
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] Beta catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells2013
- Author(s)
  Akutsu, Hidenori
- Organizer
  11th ISSCR 2013 Annual Meeting
- Place of Presentation
  Boston, MA, US
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] 着床前期胚において特異的に発現する新規SCAN-zinc finger 遺伝子Zfp371 の解析2013
- Author(s)
  小川誠司, 浜谷敏生, 阿久津英憲, 山田満稔, 奥村典子, 菅原かな, 井上治, 福永朝子, 梅澤明弘, 久慈直昭, 青木大輔, 吉村泰典
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] β-カテニンは分化多能性に必須でありその機能不全は悪性胚細胞腫瘍発生に関与している2013
- Author(s)
  奥村典子, 阿久津英憲, 浜谷敏生, 山田満稔, 菅原かな, 小川誠司, 井上治, 上條慎太郎, 梅澤明弘, 久慈直昭, 青木大輔, 吉村泰典
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] Human ES cells: aquired pluripotency from blastocysts2012
- Author(s)
  Akutsu H
- Organizer
  Asia Pacific Initiative on Reproduction 2012
- Place of Presentation
  Osak, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] Metabolomic analysis of culture media by CE-TOF/MS suggests a medium-chain fatty acid as an alternative energy source of mouse preimplantation embryos2012
- Author(s)
  Yamada M, Takanashi K, Hamatani T, Akutsu H, Fukunaga T, Ogawa S, Sugawara K, Okumura N, Chikazawa N, Kuji N, Umezawa A, Tomita M, Yoshimura Y.
- Organizer
  28th annual meeting of the European Society of Human Reproduction and Embryology
- Place of Presentation
  Istanbul
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期初期から発現し多分化能細胞に特異的に発現する新規転写因子Kzpiの機能解析2012
- Author(s)
  浜谷敏生, 山田満稔, 阿久津英憲, 小川誠司, 菅原かな, 奥村典子, 福永朝子, 井上治, 梅澤明弘, 久慈直昭, 青木大輔, 吉村泰典．
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期胚発生に関わる新規遺伝子Zfpiの発現解析2012
- Author(s)
  小川誠司, 浜谷敏生, 阿久津英憲, 山田満稔, 奥村典子, 菅原かな, 井上治, 福永朝子, 梅澤明弘, 久慈直昭, 青木大輔, 吉村泰典
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2012-04-13
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] Human ES cells : aquired pluripotency from blastocysts2012
- Author(s)
  Akutsu H
- Organizer
  Asia Pacific Initiative on Reproduction 2012
- Place of Presentation
  Osaka, Japan
- Year and Date
  2012-08-31
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] Metabolomic analysis of culture media by CE-TOF/MS suggests a medium-chain fatty acid as an alternative energy source of mouse preimplantation embryos.2012
- Author(s)
  Yamada M, Takanashi K, Hamatani T, Akutsu H, Fukunaga T, Ogawa S, Sugawara K, Okumura N, Chikazawa N, Kuji N, Umezawa A, Tomita M, Yoshimura Y.
- Organizer
  28th nnual meeting of the European Society of Human Reproduction and Embryology.
- Place of Presentation
  トルコ、イスタンブール
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期初期から発現し多分化能細胞に特異的に発現する新規転写因子Kzpiの機能解析.2012
- Author(s)
  浜谷敏生, 山田満稔, 阿久津英憲, 小川誠司, 菅原かな, 奥村典子, 福永朝子, 井上治, 梅澤明弘, 久慈直昭, 青木大輔, 吉村泰典
- Organizer
  第64回日本産科婦人科学会学術講演会
- Place of Presentation
  大阪
- Year and Date
  2012-04-13
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期および未分化維持に関わる新規C2H2-zinc finger遺伝子の解析2011
- Author(s)
  近澤奈々, 浜谷敏生, 山田満稔, 阿久津英憲, 奥村典子, 小川誠司, 菅原かな, 井上治, 福永朝子, 久慈直昭, 吉村泰典
- Organizer
  第52回日本哺乳動物卵子学会
- Place of Presentation
  大田原
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 受精からの発生で理解する幹細胞生物学2011
- Author(s)
  阿久津英憲
- Organizer
  日本生殖再生医学会第6回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-03-13
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] マウス卵子の排卵後加齢における遺伝子発現と酸素消費量との関連.2011
- Author(s)
  福永朝子, 浜谷敏生, 山田満稔, 阿部宏之, 阿久津英憲, 井上治, 小川誠司, 菅原かな, 奥村典子, 久慈直昭, 青木大輔, 吉村泰典
- Organizer
  第63回日本産科婦人科学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2011-08-30
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] Identification of a novel gene encoding a high mobility group box protein and its specific expression and essential role during preimplantation development.2011
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Kuji N, Aoki D, Yoshimura Y.
- Organizer
  The 67th Annual Meeting of the American Society for Reproductive Medicine (ASRM)
- Place of Presentation
  Orland, USA
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] Identification of a novel gene encoding a high mobility group box protein and its specific expression and essential role during preimplantation development2011
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Kuji N, Aoki D, Yoshimura Y
- Organizer
  The 67th Annual Meeting of the American Society for Reproductive Medicine (ASRM)
- Place of Presentation
  Orland, USA
- Year and Date
  2011-10-16
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] エピゲノムの基礎知識2011
- Author(s)
  阿久津英憲
- Organizer
  エピゲノムワークショップ第52回日本哺乳動物卵子学会
- Place of Presentation
  大田原
- Year and Date
  2011-05-21
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] Xeno-Free Growth and Expansion of Human Pluripotent Stem Cells2010
- Author(s)
  Hidenori Akutsu
- Organizer
  The 8^<th> ISSCR Annual Meeting
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-22659304
[Presentation] Xeno-free Growth and Expansion of Human Pluripotent Stem Cells2010
- Author(s)
  Hidenori Akutsu
- Organizer
  The 23rd Annual and International Meeting of the Japanese Association for Animal Cell Technology
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] 着床前期胚に特異的な発現が予想された新規zinc finger遺伝子の発現・機能解析2010
- Author(s)
  近澤奈々, 浜谷敏生, 山田満稔, 阿久津英憲, 奥村典子, 久慈直昭, 吉村泰典
- Organizer
  第55回日本生殖医学会・学術講演会
- Place of Presentation
  徳島(郷土文化会館・ホテルクレメント)
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 臨床グレード幹細胞樹立の試み2010
- Author(s)
  阿久津英憲
- Organizer
  第28回日本ヒト細胞学会学術集会
- Place of Presentation
  つくば市
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-22659304
[Presentation] Identification of a novel gene encoding a high mobility group box protein and its specific expression and essential role during preimplantation development.2010
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A.
- Organizer
  The First SKLRB Symposia on Frontiers in Periimplantation Biology
- Place of Presentation
  the Beijing Friendship Hotel, Beijing
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期胚に特異的な発現が予想された新規zinc finger遺伝子の発現・機能解析2010
- Author(s)
  近澤奈々,浜谷敏生,山田満稔,阿久津英憲,奥村典子,久慈直昭,吉村泰典
- Organizer
  第55回日本生殖医学会・学術講演会
- Place of Presentation
  徳島
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] Xeno-Free Growth and Expansion of Human Pluripotent Stem Cells2010
- Author(s)
  Hidenori Akutsu
- Organizer
  The 8^<th> ISSCR Annual Meeting
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] 着床前期特異的新規遺伝子Hmgpによる着床周辺期発生の制着床前期胚特異的新規遺伝子Hmgpiによる着床周辺期発生の制御機構2010
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 小川誠司, 奥村典子, 持丸佳之, 高野光子, 浅田弘法, 久慈直昭, 青木大輔, 梅澤明弘, 吉村泰典
- Organizer
  第51回日本哺乳動物卵子学会
- Place of Presentation
  新潟(朱鷺メッセ)
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期および未分化維持に関わる新規zinc finger遺伝子の解析2010
- Author(s)
  近澤奈々, 津村秀樹, 山田満稔, 浜谷敏生, 阿久津英憲, 久慈直昭, 梅澤明弘, 吉村泰典
- Organizer
  第28回受精着床学会・学術講演会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2010-07-28
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] Identification of a novel gene encoding a high mobility group box protein and its specific expression and essential role during preimplantation development.2010
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A.
- Organizer
  The 26th Annual meeting of the European Society of Human Reproduction and Embryology (ESHRE)
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] Xeno-free Growth and Expansion of Human Pluripotent Stem Cells2010
- Author(s)
  Hidenori Akutsu
- Organizer
  The 23^<rd> Annual and International Meeting of the Japanese Association for Animal Cell Technology
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22659304
[Presentation] 着床前期胚特異的新規遺伝子Hmgpiによる着床周辺期発生の制御機構2010
- Author(s)
  山田満稔,浜谷敏生,阿久津英憲,小川誠司,奥村典子,持丸佳之,高野光子,浅田弘法,久慈直昭,青木大輔,梅澤明弘,吉村泰典
- Organizer
  第51回日本哺乳動物卵子学会
- Place of Presentation
  新潟
- Year and Date
  2010-05-30
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] マウス卵子における加齢によるテロメア長短縮とテロメラーゼ活性の変化2010
- Author(s)
  山田満稔,浜谷敏生,阿久津英憲,井上治,福永朝子,小川誠司,菅原かな,奥村典子,近澤奈々,浅田弘法,久慈直昭,吉村泰典.
- Organizer
  第55回日本生殖医学会・学術講演会
- Place of Presentation
  徳島
- Year and Date
  2010-11-11
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期特異的新規遺伝子Hmgpによる着床周辺期発生の制御機構2010
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 奥村典子, 持丸佳之, 浅田弘法, 久慈直昭, 青木大輔, 吉村泰典
- Organizer
  第62回日本産科婦人科学会学術講演会
- Place of Presentation
  東京(東京国際フォーラム)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] マウス単一卵子のDNAマイクロアレイによる遺伝子発現解析とその応用2010
- Author(s)
  持丸佳之, 久慈直昭, 山田満稔, 奥村典子, 高野光子, 浜谷敏生, 阿久津英憲, 浅田弘法, 末岡浩, 青木大輔, 吉村泰典
- Organizer
  第62回日本産科婦人科学会学術講演会
- Place of Presentation
  東京(東京国際フォーラム)
- Year and Date
  2010-04-23
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 臨床グレード幹細胞樹立の試み2010
- Author(s)
  阿久津英憲
- Organizer
  第28回日本ヒト細胞学会学術集会
- Place of Presentation
  つくば市
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] Identification of a novel gene encoding a high mobility group box protein and its specific expression and essential role during preimplantation development.2010
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Chikazawa N, Kuji N, Yoshimura Y, Umezawa A.
- Organizer
  The 26th Annual meeting of the European Society of Human Reproduction and Embryology
- Place of Presentation
  Rome, Italy
- Data Source
  KAKENHI-PROJECT-22390312
[Presentation] 着床前期胚に特異的に発現する新規遺伝子Hmgpの発現および機能解析2009
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 持丸佳之, 高野光子, 浅田弘法, 久慈直昭, 青木大輔, 梅澤明弘, 吉村泰典
- Organizer
  第50回日本哺乳動物卵子学会
- Place of Presentation
  東京
- Year and Date
  2009-05-08
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] 卵活性化能は精子頭部の扁平化とpen-nucleartheca構成物質の存在に関連する2009
- Author(s)
  伊藤千鶴、阿久津英憲、八尾良司、京野廣一、鈴木-豊田二美枝、外山芳郎、前川眞見子、野田哲生、年森清隆
- Organizer
  第33回日本顕微鏡学会関東支部講演会
- Place of Presentation
  工学院大学新宿キャンパス(東京都)
- Year and Date
  2009-03-07
- Data Source
  KAKENHI-PROJECT-19591878
[Presentation] 難治性疾患克服に向けたヒトiPS細胞の可能性2009
- Author(s)
  阿久津英憲
- Organizer
  日本人類遺伝学会第54回大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] 単一卵子のDNAマイクロアレイによる遺伝子発現解析とその応用2009
- Author(s)
  持丸佳之, 久慈直昭, 山田満稔, 高野光子, 浜谷敏生, 阿久津英憲, 浅田弘法, 末岡浩, 青木大輔, 吉村泰典
- Organizer
  第27回日本受精着床学会
- Place of Presentation
  京都
- Year and Date
  2009-08-06
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] 着床前期特異的新規遺伝子Hmgpによる着床周辺期発生の制御機構2009
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 持丸佳之, 高野光子, 浅田弘法, 久慈直昭, 吉村泰典
- Organizer
  第54回日本生殖医学会・学術講演会
- Place of Presentation
  金沢
- Year and Date
  2009-11-23
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] Human Embryonic stem cells and WS Cells : Potential tool for Low temperature medical experiments2009
- Author(s)
  阿久津英憲
- Organizer
  第36回日本低温医学会総会・学術集会シンポジウム2
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-21390456
[Presentation] 先体後部鞘関連タンパク質MNI3は伸長核精子に存在し、卵活性化能と相関する2008
- Author(s)
  伊薩千鶴、阿久津英憲、鈴木-豊田二美枝、八尾良司、前川眞見子、外山芳郎、野田哲生、年森清隆
- Organizer
  第113回日本解剖学会総会・全国学術集会
- Place of Presentation
  大分大学医学部(大分県)
- Data Source
  KAKENHI-PROJECT-19591878
[Presentation] ベイシジンーGFPトランスジェニックマウスの確立と解析2008
- Author(s)
  前川眞見子, 伊薩千鶴, 宮戸健二, 阿久津英憲, 吉田恵一, 大和屋健二, 外山芳郎, 鈴木-豊田二美枝, 年森清隆
- Organizer
  第113回日本解剖学会総会・全国学術集会
- Place of Presentation
  大分大学医学部(大分県)
- Data Source
  KAKENHI-PROJECT-19591878
[Presentation] 先体後部鞘関連タンパクMNI3は伸長核精子に存在し、卵活性化能と相関する2008
- Author(s)
  伊藤千鶴、阿久津英憲、鈴木-豊田二枝美、八尾良司、外山芳郎、前川眞見子、野田哲生、年森清隆
- Organizer
  第6回アンドロロジーカンファレンス
- Place of Presentation
  目黒東急ビル6F
- Year and Date
  2008-09-28
- Data Source
  KAKENHI-PROJECT-19591878
[Presentation] マウス卵特異的新規Krab-zinc finger遺伝子の発現解析2008
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 持丸佳之, 高野光子, 浅田弘法, 久慈直昭, 吉村泰典
- Organizer
  第53回日本生殖医学会学術講演会
- Place of Presentation
  神戸
- Year and Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] マウス卵特異的新規Homeobox遺伝子の発現解析2007
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 浅田弘法, 久慈直昭, 吉村泰典
- Organizer
  第52回日本生殖医学会総会・学術講演会
- Place of Presentation
  秋田
- Year and Date
  2007-10-25
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] Identification of a novel gene encoding a b-box zinc finger protein with its specific expression and essential role during Preimplantation development2007
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Kuji N, Umezawa A, Yoshimura Y
- Organizer
  The 63th Annual Meeting of the American Society for Reproductive Medicine
- Place of Presentation
  Washington DC
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] マウス新規ホメオボックス遺伝子の卵細胞・着床前期胚における発現特異性2007
- Author(s)
  山田満稔、浜谷敏生、阿久津英憲、水澤友利、庄司真弓、羽田智則、浅田弘法、久慈直昭、青木大輔、吉村泰典
- Organizer
  弟59階日本産科婦人科学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] Identification of a novel gene encoding a b-box zinc finger protein with its specific expression and essential role during preimplantation development2007
- Author(s)
  Yamada M, Hamatani T, Akutsu H, Kuji N, Umezawa A, Yoshimura Y
- Organizer
  The 63th Annual Meeting of the American Society for Reproductive Medicine
- Place of Presentation
  Washington DC
- Year and Date
  2007-10-16
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] マウス新規ホメオボックス遺伝子の卵細胞・着床前期胚における発現特異性2007
- Author(s)
  山田満稔, 浜谷敏生, 阿久津英憲, 水澤友利, 庄司真弓, 羽田智則, 浅田弘法, 久慈直昭, 青木大輔, 吉村泰典
- Organizer
  第59階日本産科婦人科学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2007-04-16
- Data Source
  KAKENHI-PROJECT-19591911
[Presentation] 着床前期胚において特異的に発現する新規SCAN-zinc finger遺伝子Zfp371の解析．
- Author(s)
  小川誠司, 浜谷敏生, 阿久津英憲, 山田満稔, 奥村典子, 菅原かな, 井上治, 福永朝子, 梅澤明弘, 久慈直昭, 青木大輔, 吉村泰典．
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] β-カテニンは分化多能性に必須でありその機能不全は悪性胚細胞腫瘍発生に関与している．
- Author(s)
  奥村典子, 阿久津英憲, 浜谷敏生, 山田満稔, 菅原かな, 小川誠司, 井上治, 上條慎太郎, 梅澤明弘, 久慈直昭, 青木大輔, 吉村泰典．
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] キャピラリー電気泳動-飛行時間型質量分析法(CE-TOFMS)を用いたマウス着床前期胚培養液のメタボローム解析．
- Author(s)
  浜谷敏生, 山田満稔, 高梨和美, 平山明由, 阿久津英憲, 福永朝子, 小川誠司, 菅原かな, 篠田幸作, 曽我朋義, 久慈直昭, 梅澤明弘, 冨田勝, 吉村泰典．
- Organizer
  第54回日本卵子学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] 生殖医学における ES 細胞とiPS 細胞の意義
- Author(s)
  阿久津英憲
- Organizer
  第59回日本生殖医学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2014-12-04 – 2014-12-05
- Invited
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] 卵子老化機序解明に向けたES細胞の応用
- Author(s)
  阿久津英憲
- Organizer
  第32回日本受精着床学会総会・学術講演会
- Place of Presentation
  東京
- Year and Date
  2014-07-31 – 2014-08-01
- Invited
- Data Source
  KAKENHI-PROJECT-25670710
[Presentation] ヒト間葉系幹細胞から子宮内膜間質様細胞への分化誘導．
- Author(s)
  菅原かな，浜谷敏生，小川誠司，山田満稔，上條慎太郎，竹本崇史，戸田里実，若松修平，久慈直昭，阿久津英憲，梅澤明弘，青木大輔．
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] 着床前期特異的新規遺伝子Kzpiを欠失させた胚性幹細胞(ES細胞)の機能解析．
- Author(s)
  上條慎太郎, 浜谷敏生, 阿久津英憲, 小川誠司, 菅原かな, 片岡典子, 山田満稔, 久慈直昭, 吉村泰典．
- Organizer
  第58回日本生殖医学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] キャピラリー電気泳動-飛行時間型質量分析法(CE-TOFMS)を用いたマウス着床前期胚培養液のメタボローム解析．
- Author(s)
  若松修平, 山田満稔, 浜谷敏生, 阿久津英憲, 竹本崇史, 戸田里実, 上條慎太郎, 小川誠司, 菅原かな, 久慈直昭, 吉村泰典．
- Organizer
  第58回日本生殖医学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] 着床前期胚において特異的に発現する新規SCAN-zinc finger遺伝子Zfp371の解析．
- Author(s)
  小川誠司, 浜谷敏生, 阿久津英憲, 山田満稔, 奥村典子, 菅原かな, 井上おさむ, 山田朝子, 上條慎太郎, 久慈直昭, 吉村泰典．
- Organizer
  第58回日本生殖医学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] ヒト間葉系幹細胞から子宮内膜間質様細胞への分化誘導．
- Author(s)
  菅原かな, 浜谷敏生, 小川誠司, 山田満稔, 山田朝子, 上條慎太郎, 竹本崇史, 戸田里実, 若松修平, 久慈直昭, 阿久津英憲, 梅澤明弘, 吉村泰典．
- Organizer
  第58回日本生殖医学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] 卵子老化機序解明に向けた ES細胞の応用
- Author(s)
  阿久津英憲
- Organizer
  第32回日本受精着床学会総会・学術講演会
- Place of Presentation
  東京
- Year and Date
  2014-07-31 – 2014-08-01
- Invited
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] マウスES細胞におけるβ-cateninの多面的役割．
- Author(s)
  奥村典子, 阿久津英憲, 菅原亨, 三浦巧, 竹澤侑希, 細田明弘, 吉田恵一, Ichida Justin K., 山田満稔, 浜谷敏生, 宮戸健二, 久慈直昭, 梅澤明弘, 吉村泰典．
- Organizer
  第54回日本卵子学会大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25293345
[Presentation] Human induced plurippotent stem cells for disease modeling
- Author(s)
  Hidenori AKUTSU
- Organizer
  8th International Symposium of Rare DiseaseResearch
- Place of Presentation
  韓国ソウル
- Year and Date
  2014-09-18 – 2014-09-20
- Invited
- Data Source
  KAKENHI-PROJECT-26293364
[Presentation] 着床前期胚において特異的に発現する新規SCAN-zinc finger遺伝子 Zfp371 のノックアウトマウスおよびノックアウト胚性幹細胞における機能解析
- Author(s)
  小川誠司，浜谷敏生，阿久津英憲，山田満稔，菅原かな，井上治，戸田里実，若松修平，梅澤明弘，久慈直昭，青木大輔，吉村泰典．
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-25293345

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AKUTSU Hidenori 阿久津 英憲

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生命発動と器官発生・制御に関わるヒト受精胚分子機序の解明Principal Investigator

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Development of a Human Taste-Small Intestine-Brain Correlation Model applying for Nutritional PhysiologyPrincipal Investigator

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Elucidation of oocyte molecular mechanism on imprinted X chromosome inactivation enabling a sequential developmentPrincipal Investigator

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AKUTSU Hidenori 阿久津英憲