FUJITA Motoki 藤田基

Researcher Number	50380001
Other IDs
Affiliation *help	2012 – 2018 : 山口大学, 医学(系)研究科(研究院), 助教 2015 – 2018 : 山口大学, 大学院医学系研究科, 助教 2010 : Yamaguchi University, 医学(系)研究科(研究院), 助教 2008 – 2009 : Yamaguchi University, 大学院・医学系研究科, 助教 2007 : Yamaguchi University, 医学部・附属病院, 医員
Review Section/Research Field	Principal Investigator Emergency medicine / Basic Section 55060:Emergency medicine-related Except Principal Investigator Emergency medicine / Neurosurgery
Keywords	Principal Investigator HMGB1 / オリゴデンドロサイト / スーパーオキシドラジカル / 生体内持続ラジカル測定法 / 軸索損傷 / 頭部外傷 / 経時的測定法 / 活性酸素種 / 高気圧酸素治療 / 一酸化炭素中毒 … More Except Principal Investigator バイオマーカー / 酸化ストレス / 心停止後症候群 / 質量分析計 / 重症頭部外傷 / 脳低温療法 / 水素水 / フリーラジカル / HMGB1 / 虚血再灌流障害 / 医師主導型臨床研究 / 積極的平温療法 / 蛋白質カタログ / 予後予測 / 熱中症 / マロン酸アルデヒド / 蘇生 / 神経集中治療 / 網羅的プロテオーム解析 / sICAM1 / 頭蓋内圧 / 低体温療法 / ナノフロー高速液体クロマトグラフ / 心停止 / 頭部外傷 / 心室細動 / 二次性脳損傷 / 脳保護 Less

一酸化炭素中毒の病態解明と水素ガス吸入による新規治療法の確立Principal InvestigatorOngoing
- Principal Investigator
  
  藤田基
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Yamaguchi University
水素吸入療法を軸とした新たな頭部外傷の治療法の確立Principal InvestigatorOngoing
- Principal Investigator
  
  藤田基
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Yamaguchi University
重症熱中症に対する水素を用いた新たな治療戦略Ongoing
- Principal Investigator
  
  小田泰崇
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Yamaguchi University
The evaluation of cerebral protective effect of hypothermia therapy for traumatic brain injury patients with evacuated mass lesions
- Principal Investigator
  
  SUEHIRO Eiichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Yamaguchi University
Predictive value of serum NGAL for the neurological outcome of post cardiac arrest victims
- Principal Investigator
  
  KASAOKA SHUNJI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Kumamoto University
Establishment of Therapy for Traumatic Brain Injury Focused on Superoxide and HMGB1.Principal Investigator
- Principal Investigator
  
  FUJITA Motoki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Yamaguchi University
Combinational therapy using hypothermia and FK506 to target oxidative stress, endothelial injury, inflammation, and ischemic brain injury after cardiac arrest in rat
- Principal Investigator
  
  ODA Yasutaka
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Emergency medicine
- Research Institution
  Yamaguchi University
ラット熱中症モデルにおける活性酸素傷害の解明と治療法の確立Principal Investigator
- Principal Investigator
  
  藤田基
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Yamaguchi University
網羅的プロテオーム解析とプロテオームデータベース構築による救命救急傷病の病態解明
- Principal Investigator
  
  前川剛志
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Yamaguchi University
EstabIishment of in vivo monitoring of superoxide and investigation of oxidative stressPrincipal Investigator
- Principal Investigator
  
  FUJITA Motoki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Emergency medicine
- Research Institution
  Yamaguchi University

All 2015 2014 2013 2010 2009 2008 2007 Other

All Journal Article Presentation

[Journal Article] Diverse effects of hypothermia therapy in patients with severe traumatic brain injury based on the CT classification of the Traumatic Coma Data Bank2015
- Author(s)
  Suehiro E, Koizumi H, Fujisawa H, Fujita M, Kaneko T, Oda Y, Yamashita S, Tsuruta R, Maekawa T, Suzuki M
- Journal Title
  
  J Neurotrauma
  
  Volume : 32 Pages : 353-358
- DOI
  10.1089/neu.2014.3584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25462219
[Journal Article] Moderate hypothermia suppressed excessive generation of superoxide anion radical and inflammatory reactions in blood and liver in heatstroke : laboratory study in rats2010
- Author(s)
  Todani M, Fujita M, Tsuruta R, et al.
- Journal Title
  
  Free Radical Research 44
  
  Pages : 462-472
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21791766
[Presentation] ラット頭部外傷モデルにおけるHMGB1の発現～受傷早期のcytoplasmic HMGB1の局在とその意義について2014
- Author(s)
  藤田基
- Organizer
  山口県神経損傷クリティカルケア研究会
- Place of Presentation
  ANAクラウンプラザ宇部（山口県）
- Data Source
  KAKENHI-PROJECT-24592737
[Presentation] ラット頭部外傷モデルにおける受傷早期のHMGB1の局在とその意義について2013
- Author(s)
  藤田基、小田泰崇、戸谷昌樹、中原貴志、金子唯、金田浩太郎、河村宜克、鶴田良介
- Organizer
  第41回日本救急医学会総会学術集会
- Place of Presentation
  東京国際フォーラム（東京都）
- Data Source
  KAKENHI-PROJECT-24592737
[Presentation] Superoxide generation in blood is associated with HMGB1 expression and release in heatstroke rats.2010
- Author(s)
  Todani M, Fujita M, Nakahara T, et al.
- Organizer
  39th Critical Care Congress
- Place of Presentation
  Miami, Florida, USA
- Year and Date
  2010-01-10
- Data Source
  KAKENHI-PROJECT-21791766
[Presentation] 生体内スーパーオキシドラジカルモニタリング : 新技術による各種病態把握と治療手段としての可能性2009
- Author(s)
  前川剛志、藤田基
- Organizer
  第36回日本集中治療医学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-02-27
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] Moderate hypothermia suppresses brain and liver injury via attenuating excessive generation of superoxide anion radical in heatstroke rats.2009
- Author(s)
  Todani M, Fujita M, Tsuruta R, et al.
- Organizer
  3rd International Hypothermia Symposium
- Place of Presentation
  Lund, Sweden
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-21791766
[Presentation] ラット前脳虚血再潅流モデルにおける血流中スーパーオキシドラジカル測定法の確立とスーパーオキシド-HMGB1の相関について2008
- Author(s)
  藤田基
- Organizer
  第36回日本救急医学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-15
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] 脳虚血再潅流時のスーパーオキシドモニタリング2008
- Author(s)
  藤田基
- Organizer
  第14回脳代謝モニタリング研究会
- Place of Presentation
  東京
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] Xanthine Oxidase is the Major Source of Superoxide Radical in the Forebrain Ischemia-Reperfusion Rat2008
- Author(s)
  笠岡俊志、藤田基
- Organizer
  The XIV Biennial Meeting of the Society for Free Radical Research Intemational (14th SFRR)
- Place of Presentation
  北京
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] Cholinergic Agonist, Physostigmine inhibits Superoxide Radical Generation in the Jugular Vein in the Forebrain Ischemia-Reperfhsion Rat2008
- Author(s)
  鶴田良介、藤田基
- Organizer
  The XIV Biennial Meeting of the Society for Free Radical Research Intemational (14th SFRR)
- Place of Presentation
  北京
- Year and Date
  2008-10-18
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] Moderate Hypothermia Suppresses Superoxide Radical Generation in the Jugular Vein in the Forebrain Ischemia-Reperfusion Rat2008
- Author(s)
  藤田基
- Organizer
  The XIV Biennial Meeting of the Society for Free Radical Research Intemational (14th SFRR)
- Place of Presentation
  北京
- Year and Date
  2008-10-20
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] ラット前脳虚血再潅流モデルにおける血流中スーパーオキシドラジカル測定法の確立とスパーオキシド-HMGB 1の相関について2008
- Author(s)
  藤田基
- Organizer
  第36回日本救急医学会総会
- Place of Presentation
  札幌
- Year and Date
  2008-10-15
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] 脳虚血再潅流時のスーパーオキシドモニタリング2008
- Author(s)
  藤田基
- Organizer
  第14回脳代謝モニタリング研究会
- Place of Presentation
  東京
- Year and Date
  2008-07-05
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] Moderate Hypothermia Suppresses Superoxide Radical Generation in the Jugular Vein in the Forebrain Ischemia-Reperfusion Rat2008
- Author(s)
  Motoki Fujita
- Organizer
  The XIV Biennial Meeting of the Society for Free Radical Research International (14th SFRR)
- Place of Presentation
  Beijing, China
- Year and Date
  2008-10-20
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] 臨床応用を意図したスーパーオキシド電極による生体内持続ラジカル測定2007
- Author(s)
  藤田基
- Organizer
  第5回"フリーラジカルと脳疾患"西日本研究会学術集会
- Place of Presentation
  大阪
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] In vivo detection of superoxide anion radicals by a new lydeveloped electrochemical sensor in brain ischemia-reperfhsion rats2007
- Author(s)
  藤田基
- Organizer
  Brain'07 & Brain PET'07
- Place of Presentation
  大阪
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] 臨床応用を意図したスーパーオキシド電極による生体内持続ラジカル測定2007
- Author(s)
  藤田基
- Organizer
  第五回"フリーラジカルと脳疾患"西日本研究会学術集会
- Place of Presentation
  梅田スカイビル(大阪市)
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] In vivo detection of superoxide-anion radicals by a newly developed electrochemical sensor in brain ischemia-reperfusion rats.2007
- Author(s)
  Motoki Fujita
- Organizer
  The 23th International Symposium on Cerebral Blood Flow, Metabolism & Function
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2007-05-22
- Data Source
  KAKENHI-PROJECT-19791328
[Presentation] High Mobility Group Box-1 (HMGB1) Expression in Oligodendrocytes of Rats Subjected to Lateral Fluid Percussion Injury (LFPI).
- Author(s)
  Fujita M, Oda Y, Miyauchi T, Tsuruta R, Povlishock JT
- Organizer
  The 32nd Annual National Neurotrauma Symposium
- Place of Presentation
  San Francisco (USA)
- Year and Date
  2014-06-29 – 2014-07-02
- Data Source
  KAKENHI-PROJECT-24592737

1. ODA Yasutaka (40397998)

# of Collaborated Projects : 6results

# of Collaborated Products : 3results
2. TSURUTA Ryosuke (30263768)

# of Collaborated Projects : 4results

# of Collaborated Products : 3results
3. KASAOKA SHUNJI (90243667)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
4. 宮内崇 (40380000)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
5. SUEHIRO Eiichi (10363110)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
6. KOIZUMI Hiroyasu (40423389)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
7. SUZUKI Michiyasu (80196873)

# of Collaborated Projects : 1results

# of Collaborated Products : 1results
8. 前川剛志 (60034972)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
9. 松崎益徳 (60116754)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
10. 泉友則 (00261694)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 金子唯 (50362372)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results

FUJITA Motoki 藤田 基

Research Projects

Research Products

Co-Researchers

一酸化炭素中毒の病態解明と水素ガス吸入による新規治療法の確立Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

水素吸入療法を軸とした新たな頭部外傷の治療法の確立Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

重症熱中症に対する水素を用いた新たな治療戦略Ongoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The evaluation of cerebral protective effect of hypothermia therapy for traumatic brain injury patients with evacuated mass lesions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Predictive value of serum NGAL for the neurological outcome of post cardiac arrest victims

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of Therapy for Traumatic Brain Injury Focused on Superoxide and HMGB1.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Combinational therapy using hypothermia and FK506 to target oxidative stress, endothelial injury, inflammation, and ischemic brain injury after cardiac arrest in rat

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ラット熱中症モデルにおける活性酸素傷害の解明と治療法の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

網羅的プロテオーム解析とプロテオームデータベース構築による救命救急傷病の病態解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

EstabIishment of in vivo monitoring of superoxide and investigation of oxidative stressPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Diverse effects of hypothermia therapy in patients with severe traumatic brain injury based on the CT classification of the Traumatic Coma Data Bank2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Moderate hypothermia suppressed excessive generation of superoxide anion radical and inflammatory reactions in blood and liver in heatstroke : laboratory study in rats2010

Author(s)

Journal Title

Data Source

[Presentation] ラット頭部外傷モデルにおけるHMGB1の発現～受傷早期のcytoplasmic HMGB1の局在とその意義について2014

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ラット頭部外傷モデルにおける受傷早期のHMGB1の局在とその意義について2013

Author(s)

FUJITA Motoki 藤田基