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Fujita Motoki  藤田 基

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FUJITA Motoki  藤田 基

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Researcher Number 50380001
Other IDs
Affiliation (Current) 2025: 山口大学, 大学院医学系研究科, 准教授
Affiliation (based on the past Project Information) *help 2025: 山口大学, 大学院医学系研究科, 准教授
2019 – 2023: 山口大学, 大学院医学系研究科, 准教授
2018: 山口大学, 医学部附属病院, 助教
2017: 山口大学, 大学院医学系研究科, 助教
2012 – 2016: 山口大学, 医学(系)研究科(研究院), 助教 … More
2015: 山口大学, 大学院医学系研究科, 助教
2010: Yamaguchi University, 医学(系)研究科(研究院), 助教
2008 – 2009: Yamaguchi University, 大学院・医学系研究科, 助教
2007: Yamaguchi University, 医学部・附属病院, 医員 Less
Review Section/Research Field
Principal Investigator
Emergency medicine / Basic Section 55060:Emergency medicine-related
Except Principal Investigator
Emergency medicine / Basic Section 55060:Emergency medicine-related / Neurosurgery
Keywords
Principal Investigator
HMGB1 / 水素 / オリゴデンドロサイト / 一酸化炭素中毒 / 水素ガス / 軸索損傷 / 頭部外傷 / スーパーオキシドラジカル / 生体内持続ラジカル測定法 / 髄鞘 … More / 脱髄 / クレマスチン / 水素ガス吸入 / 高気圧酸素治療 / 急性一酸化炭素中毒 / activated caspase-3 / MDA / 酸化ストレス / アポトーシス / 間歇型 / 水素吸入 / 脳挫傷 / 壊死 / ニューロン / ICAM-1 / マロン酸アルデヒド / 肝障害 / 熱中症 / ラットエンドトキシン血症モデル / ラット前脳虚血再潅流モデル / 脳虚血再潅流 / モニタリング / スーパーオキシド / エンドトキシン血症 / 前脳虚血再潅流 / 経時的測定法 / スーパーオキシドアニオンラジカル / 活性酸素種 … More
Except Principal Investigator
熱中症 / バイオマーカー / 酸化ストレス / 心停止後症候群 / グリコカリックス / 水素療法 / 水素吸入 / N-アセチルシステイン / 臓器障害 / Nアセチルシステイン / 水素吸入療法 / 予後予測 / 炎症 / 水素水 / 全身炎症反応 / 分子状水素 / 頭蓋内圧 / 積極的平温療法 / 二次性脳損傷 / 重症頭部外傷 / 神経集中治療 / フリーラジカル / 脳低温療法 / 頭部外傷 / 低体温療法 / 脳保護 / 蘇生 / 心停止 / 虚血再灌流障害 / HMGB1 / sICAM1 / マロン酸アルデヒド / 心室細動 / ナノフロー高速液体クロマトグラフ / 医師主導型臨床研究 / 蛋白質カタログ / 質量分析計 / 網羅的プロテオーム解析 Less
  • Research Projects

    (13 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (15 People)
  •  熱中症ラットの血管内皮グリコカリックス障害の解析と水素療法による新規治療法の開発

    • Principal Investigator
      綾田 亮
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Yamaguchi University
  •  ラットを用いた薬物と水素吸入による髄鞘保護を主眼としたCO中毒の新規治療法の確立Principal Investigator

    • Principal Investigator
      藤田 基
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Yamaguchi University
  •  The Development of Novel Treatments Using N-Acetylcysteine and Hydrogen Inhalation in a Rat Heatstroke Model

    • Principal Investigator
      Nakahara Takashi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Yamaguchi University
  •  Elucidation of the pathophysiology of carbon monoxide poisoning and establishment of a novel treatment by hydrogen inhalationPrincipal Investigator

    • Principal Investigator
      Fujita Motoki
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Yamaguchi University
  •  Establishment of novel therapy with hydrogen gas inhalation for traumatic brain injuryPrincipal Investigator

    • Principal Investigator
      FUJITA Motoki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Yamaguchi University
  •  Beneficial effects of Molecular hydrogen in rat model of heat stroke

    • Principal Investigator
      ODA Yasutaka
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Yamaguchi University
  •  The evaluation of cerebral protective effect of hypothermia therapy for traumatic brain injury patients with evacuated mass lesions

    • Principal Investigator
      SUEHIRO Eiichi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Yamaguchi University
  •  Predictive value of serum NGAL for the neurological outcome of post cardiac arrest victims

    • Principal Investigator
      KASAOKA SHUNJI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Kumamoto University
  •  Establishment of Therapy for Traumatic Brain Injury Focused on Superoxide and HMGB1.Principal Investigator

    • Principal Investigator
      FUJITA Motoki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Yamaguchi University
  •  Combinational therapy using hypothermia and FK506 to target oxidative stress, endothelial injury, inflammation, and ischemic brain injury after cardiac arrest in rat

    • Principal Investigator
      ODA Yasutaka
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Emergency medicine
    • Research Institution
      Yamaguchi University
  •  ラット熱中症モデルにおける活性酸素傷害の解明と治療法の確立Principal Investigator

    • Principal Investigator
      藤田 基
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Yamaguchi University
  •  網羅的プロテオーム解析とプロテオームデータベース構築による救命救急傷病の病態解明

    • Principal Investigator
      前川 剛志
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Emergency medicine
    • Research Institution
      Yamaguchi University
  •  EstabIishment of in vivo monitoring of superoxide and investigation of oxidative stressPrincipal Investigator

    • Principal Investigator
      FUJITA Motoki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Yamaguchi University

All 2017 2015 2014 2013 2010 2009 2008 2007 Other

All Journal Article Presentation

  • [Journal Article] Diverse effects of hypothermia therapy in patients with severe traumatic brain injury based on the CT classification of the Traumatic Coma Data Bank2015

    • Author(s)
      Suehiro E, Koizumi H, Fujisawa H, Fujita M, Kaneko T, Oda Y, Yamashita S, Tsuruta R, Maekawa T, Suzuki M
    • Journal Title

      J Neurotrauma

      Volume: 32 Issue: 5 Pages: 353-358

    • DOI

      10.1089/neu.2014.3584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25462219
  • [Journal Article] Moderate hypothermia suppressed excessive generation of superoxide anion radical and inflammatory reactions in blood and liver in heatstroke : laboratory study in rats2010

    • Author(s)
      Todani M, Fujita M, Tsuruta R, et al.
    • Journal Title

      Free Radical Research 44

      Pages: 462-472

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791766
  • [Presentation] ラット熱中症モデルを用いた分子状水素の効果の検討2017

    • Author(s)
      小田 泰崇、藤田 基、鶴田 良介、前川 剛志、西嶋 陽、中島 健太郎、井上 吾一、小池 国彦
    • Organizer
      第7回日本分子状水素医学生物学会
    • Data Source
      KAKENHI-PROJECT-15K10983
  • [Presentation] ラット頭部外傷モデルにおけるHMGB1の発現~受傷早期のcytoplasmic HMGB1の局在とその意義について2014

    • Author(s)
      藤田基
    • Organizer
      山口県神経損傷クリティカルケア研究会
    • Place of Presentation
      ANAクラウンプラザ宇部(山口県)
    • Data Source
      KAKENHI-PROJECT-24592737
  • [Presentation] ラット頭部外傷モデルにおける受傷早期のHMGB1の局在とその意義について2013

    • Author(s)
      藤田基、小田泰崇、戸谷昌樹、中原貴志、金子唯、金田浩太郎、河村宜克、鶴田良介
    • Organizer
      第41回日本救急医学会総会学術集会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Data Source
      KAKENHI-PROJECT-24592737
  • [Presentation] Superoxide generation in blood is associated with HMGB1 expression and release in heatstroke rats.2010

    • Author(s)
      Todani M, Fujita M, Nakahara T, et al.
    • Organizer
      39th Critical Care Congress
    • Place of Presentation
      Miami, Florida, USA
    • Year and Date
      2010-01-10
    • Data Source
      KAKENHI-PROJECT-21791766
  • [Presentation] Moderate hypothermia suppresses brain and liver injury via attenuating excessive generation of superoxide anion radical in heatstroke rats.2009

    • Author(s)
      Todani M, Fujita M, Tsuruta R, et al.
    • Organizer
      3rd International Hypothermia Symposium
    • Place of Presentation
      Lund, Sweden
    • Year and Date
      2009-09-03
    • Data Source
      KAKENHI-PROJECT-21791766
  • [Presentation] 生体内スーパーオキシドラジカルモニタリング : 新技術による各種病態把握と治療手段としての可能性2009

    • Author(s)
      前川剛志、藤田基
    • Organizer
      第36回日本集中治療医学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-02-27
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] ラット前脳虚血再潅流モデルにおける血流中スーパーオキシドラジカル測定法の確立とスーパーオキシド-HMGB1の相関について2008

    • Author(s)
      藤田基
    • Organizer
      第36回日本救急医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-15
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] ラット前脳虚血再潅流モデルにおける血流中スーパーオキシドラジカル測定法の確立とスパーオキシド-HMGB 1の相関について2008

    • Author(s)
      藤田基
    • Organizer
      第36回日本救急医学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2008-10-15
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] Cholinergic Agonist, Physostigmine inhibits Superoxide Radical Generation in the Jugular Vein in the Forebrain Ischemia-Reperfhsion Rat2008

    • Author(s)
      鶴田良介、藤田基
    • Organizer
      The XIV Biennial Meeting of the Society for Free Radical Research Intemational (14th SFRR)
    • Place of Presentation
      北京
    • Year and Date
      2008-10-18
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] Moderate Hypothermia Suppresses Superoxide Radical Generation in the Jugular Vein in the Forebrain Ischemia-Reperfusion Rat2008

    • Author(s)
      Motoki Fujita
    • Organizer
      The XIV Biennial Meeting of the Society for Free Radical Research International (14th SFRR)
    • Place of Presentation
      Beijing, China
    • Year and Date
      2008-10-20
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] Xanthine Oxidase is the Major Source of Superoxide Radical in the Forebrain Ischemia-Reperfusion Rat2008

    • Author(s)
      笠岡俊志、藤田基
    • Organizer
      The XIV Biennial Meeting of the Society for Free Radical Research Intemational (14th SFRR)
    • Place of Presentation
      北京
    • Year and Date
      2008-10-18
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] Moderate Hypothermia Suppresses Superoxide Radical Generation in the Jugular Vein in the Forebrain Ischemia-Reperfusion Rat2008

    • Author(s)
      藤田基
    • Organizer
      The XIV Biennial Meeting of the Society for Free Radical Research Intemational (14th SFRR)
    • Place of Presentation
      北京
    • Year and Date
      2008-10-20
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] 脳虚血再潅流時のスーパーオキシドモニタリング2008

    • Author(s)
      藤田基
    • Organizer
      第14回脳代謝モニタリング研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-05
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] 臨床応用を意図したスーパーオキシド電極による生体内持続ラジカル測定2007

    • Author(s)
      藤田基
    • Organizer
      第5回"フリーラジカルと脳疾患"西日本研究会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-10
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] In vivo detection of superoxide-anion radicals by a newly developed electrochemical sensor in brain ischemia-reperfusion rats.2007

    • Author(s)
      Motoki Fujita
    • Organizer
      The 23th International Symposium on Cerebral Blood Flow, Metabolism & Function
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2007-05-22
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] In vivo detection of superoxide anion radicals by a new lydeveloped electrochemical sensor in brain ischemia-reperfhsion rats2007

    • Author(s)
      藤田基
    • Organizer
      Brain'07 & Brain PET'07
    • Place of Presentation
      大阪
    • Year and Date
      2007-05-22
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] 臨床応用を意図したスーパーオキシド電極による生体内持続ラジカル測定2007

    • Author(s)
      藤田 基
    • Organizer
      第五回"フリーラジカルと脳疾患"西日本研究会学術集会
    • Place of Presentation
      梅田スカイビル(大阪市)
    • Year and Date
      2007-11-10
    • Data Source
      KAKENHI-PROJECT-19791328
  • [Presentation] High Mobility Group Box-1 (HMGB1) Expression in Oligodendrocytes of Rats Subjected to Lateral Fluid Percussion Injury (LFPI).

    • Author(s)
      Fujita M, Oda Y, Miyauchi T, Tsuruta R, Povlishock JT
    • Organizer
      The 32nd Annual National Neurotrauma Symposium
    • Place of Presentation
      San Francisco (USA)
    • Year and Date
      2014-06-29 – 2014-07-02
    • Data Source
      KAKENHI-PROJECT-24592737
  • 1.  ODA Yasutaka (40397998)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 4 results
  • 2.  TSURUTA Ryosuke (30263768)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 3.  KASAOKA SHUNJI (90243667)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  Nakahara Takashi (10560956)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  宮内 崇 (40380000)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  SUEHIRO Eiichi (10363110)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  KOIZUMI Hiroyasu (40423389)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  SUZUKI Michiyasu (80196873)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  前川 剛志 (60034972)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  松崎 益徳 (60116754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  泉 友則 (00261694)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  金子 唯 (50362372)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  八木 雄史 (20812910)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  綾田 亮 (91013126)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  戸谷 昌樹 (00585721)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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