KAWARAZAKI Wakako 河原崎和歌子

Researcher Number	50424594
Affiliation *help	2018 : 東京大学, 先端科学技術研究センター, 特任助教 2018 : 東京大学, 先端科学技術研究センター, 研究員 2013 – 2017 : 東京大学, 先端科学技術研究センター, 特任研究員 2015 : 東京大学, 先端科学技術研究センター臨床エピジェネティクス講座, 特任研究員 2015 : 東京大学, 先端科学技術研究センター, 研究員
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53020:Cardiology-related Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator 肥満 / 食塩感受性高血圧 / 食塩感受性 / アルドステロン / ミネラロコルチコイド受容体 / Na輸送体 / Rac1 / エピジェネティクス / klotho / 腎尿細管 … More Except Principal Investigator アルドステロン / DNAメチル化 / アンジオテンシン / ミネラルコルチコイド / 食塩感受性高血圧 / 高血圧 / コルチゾール / エピジェネティクス / 腎障害 / 糖尿病性腎症 / 近位尿細管 / 内科 / ミネラルコルチコイド受容体 Less

加齢に伴う食塩感受性高血圧発症機序の解明と新規治療戦略Principal InvestigatorOngoing
- Principal Investigator
  
  河原崎和歌子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunctionOngoing
- Principal Investigator
  
  藤田敏郎
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
肥満におけるアディポカイン分泌異常による高血圧・腎障害発症機序の解明Principal InvestigatorOngoing
- Principal Investigator
  
  河原崎和歌子
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索
- Principal Investigator
  
  藤田敏郎
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Exploration of epigenetic abnormality of diabetic kidney disease for novel therapy
- Principal Investigator
  
  Marumo Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Exploring the Epigenetic Abnormalities of Mineralocorticoid Receptor Activation in Salt-sensitive Hypertension and NephropathyPrincipal Investigator
- Principal Investigator
  
  KAWARAZAKI Wakako
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury.2016
- Author(s)
  Nobuhiro Ayuzawa, Miki Nagase, Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Takeshi Marumo, Atsu Aiba, Takayuki Sakurai, Takayuki Shindo, Toshiro Fujita
- Journal Title
  
  Hypertension.
  
  Volume : 67 Pages : 99-106
- DOI
  10.1161/HYPERTENSIONAHA.115.06054
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860546, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-25461230, KAKENHI-PROJECT-26670153, KAKENHI-PROJECT-26670426, KAKENHI-PROJECT-26670427, KAKENHI-PROJECT-26293085
[Journal Article] The Role of Aldosterone in Obesity-Related Hypertension.2016
- Author(s)
  Wakako Kawarazaki and Toshiro Fujita.
- Journal Title
  
  American Journal of Hypertension
  
  Volume : 29 Pages : 415-423
- DOI
  10.1093/ajh/hpw003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19443
[Journal Article] Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney2015
- Author(s)
  Marumo T, Yagi S, Kawarazaki W, Nishimoto M, Ayuzawa N, Watanabe A, Ueda K, Hirahashi J, Hishikawa K, Sakurai H, Shiota K, Fujita T.
- Journal Title
  
  J Am Soc Nephrol
  
  Volume : 印刷中 Pages : 2333-2397
- DOI
  10.1681/ASN.2014070665
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860669, KAKENHI-PROJECT-15H03001, KAKENHI-PROJECT-25461230, KAKENHI-PROJECT-26670426
[Journal Article] Rac1-mediated activation of mineralocorticoid receptor in pressure overload-induced cardiac injury2015
- Author(s)
  Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Sakurai T, Shindo T, Fujita T
- Journal Title
  
  Hypertension
  
  Volume : in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02538
[Journal Article] 食塩と高血圧研究の最前線2015
- Author(s)
  河原崎和歌子、藤田敏郎
- Journal Title
  
  実験医学増刊　先制医療
  
  Volume : 33 Pages : 72-78
- Data Source
  KAKENHI-PROJECT-25860669
[Journal Article] 腎疾患とエピジェネティクス2013
- Author(s)
  河原崎和歌子、藤田敏郎
- Journal Title
  
  Nephrology Frontier
  
  Volume : 12 Pages : 408-413
- Data Source
  KAKENHI-PROJECT-25860669
[Journal Article] 生活習慣病とエピジェネティクス2013
- Author(s)
  河原崎和歌子、藤田敏郎
- Journal Title
  
  Nephrology Frontier
  
  Volume : 12 Pages : 308-313
- Data Source
  KAKENHI-PROJECT-25860669
[Journal Article] 2013. Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive hypertension2013
- Author(s)
  Kawarazaki, W., and Fujita, T
- Journal Title
  
  Clin Exp Pharmacol Physiol.
  
  Volume : 40 Pages : 929-936
- DOI
  10.1111/1440-1681.12177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229012, KAKENHI-PROJECT-24659410, KAKENHI-PROJECT-25860669
[Journal Article] Rac1とRAAS2013
- Author(s)
  河原崎和歌子、長瀬美樹
- Journal Title
  
  Angiotensin　Research
  
  Volume : 10 Pages : 226-233
- Data Source
  KAKENHI-PROJECT-25860669
[Presentation] 抗加齢因子Klotho発現低下に伴う食塩感受性高血圧発症機序の解明2017
- Author(s)
  河原崎和歌子
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2017-06-17
- Data Source
  KAKENHI-PROJECT-15K19443
[Presentation] The mechanism of blood pressure elevation in distal nephron-specific Hsd11b2 knockout mice2016
- Author(s)
  Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Nobuhiro Ayuzawa, Daigoro Hirohama, Atsushi Watanabe, Takeshi Marumo, Toshiro Fujita
- Organizer
  The 41st International Aldosterone Conference Aldosterone and Mineralocorticoids
- Place of Presentation
  Boston, USA
- Year and Date
  2016-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Eplerenoneは塩分過剰摂取によるRA系阻害抵抗性腎障害を抑制する−EVALUATE試験サブ解析−2015
- Author(s)
  西本光宏、大津洋、丸茂丈史、河原崎和歌子、鮎澤信宏、上田浩平、広浜大五郎、渡邉篤史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 遠位ネフロン特異的Rac1欠損マウスを用いたRac1-ミネラロコルチコイド受容体（MR）経路の解析2015
- Author(s)
  鮎澤信宏、上田浩平、広浜大五郎、西本光宏、河原崎和歌子、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Epigenetic abnormalities underlie increased expression of nuclear receptor PXR in diabetic kidney disease2015
- Author(s)
  Atsushi Watanabe, Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Hiroo Kumagai, Toshiro Fujita
- Organizer
  Kidney Week 2015 ASN Annual Meeting
- Place of Presentation
  San Diego Convention Center, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 糖尿病性腎症にみられるエピジェネティック異常は血糖治療に抵抗性を示す2015
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、渡邉篤史、上田浩平、菱川慶一、櫻井裕之、藤田敏郎
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ　東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 近位尿細管の核内受容体Pxrは糖尿病腎症でエピゲノム変化を介して発現が更新する2015
- Author(s)
  渡邉篤史　丸茂丈史　河原崎和歌子　西本光宏　鮎澤信宏　広浜大五郎　上田浩平　熊谷裕生　藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] Epigenetic abnormalities underlie increased expression of nuclear receptor PXR in diabetic kidney disease2015
- Author(s)
  Atsushi Watanabe, Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Hiroo Kumagai, Toshiro Fujita
- Organizer
  Kidney Week 2015 ASN Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病による腎臓近位尿細管DNAメチル化異常2014
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、渡邉篤史、早川晃司、廣澤瑞子、塩田邦郎、藤田敏郎
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Year and Date
  2014-05-26
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 糖尿病性腎症にみられる治療抵抗性エピジェネティック異常2014
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、渡邉篤史、菱川慶一、櫻井裕之、藤田敏郎
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 糖尿病性腎症にみられる治療抵抗性DNAメチル化異常2014
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、上田浩平、渡邉篤史、藤田敏郎
- Organizer
  第6回腎疾患と高血圧研究会
- Place of Presentation
  東京
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PROJECT-25461230

1. Marumo Takeshi (70265817)

# of Collaborated Projects : 3results

# of Collaborated Products : 13results
2. 藤田敏郎 (10114125)

# of Collaborated Projects : 2results

# of Collaborated Products : 8results
3. 広浜大五郎 (20749353)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
4. 鮎澤信宏 (50459517)

# of Collaborated Projects : 2results

# of Collaborated Products : 2results
5. 柴田茂 (60508068)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
6. 下澤達雄 (90231365)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
7. 西本光宏 (90646572)

# of Collaborated Projects : 2results

# of Collaborated Products : 6results
8. 大庭成喜 (80361492)

# of Collaborated Projects : 2results

# of Collaborated Products : 0results
9. 上田浩平 (80735697)

# of Collaborated Projects : 1results

# of Collaborated Products : 5results
10. 森典子 (80431857)

# of Collaborated Projects : 1results

# of Collaborated Products : 0results
11. 菱川慶一

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
12. 新藤隆行

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
13. 桜井敬之

# of Collaborated Projects : 0results

# of Collaborated Products : 1results
14. 長瀬美樹

# of Collaborated Projects : 0results

# of Collaborated Products : 1results

KAWARAZAKI Wakako 河原崎 和歌子

Research Projects

Research Products

Co-Researchers

加齢に伴う食塩感受性高血圧発症機序の解明と新規治療戦略Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunctionOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

肥満におけるアディポカイン分泌異常による高血圧・腎障害発症機序の解明Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of epigenetic abnormality of diabetic kidney disease for novel therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring the Epigenetic Abnormalities of Mineralocorticoid Receptor Activation in Salt-sensitive Hypertension and NephropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Aldosterone in Obesity-Related Hypertension.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rac1-mediated activation of mineralocorticoid receptor in pressure overload-induced cardiac injury2015

Author(s)

Journal Title

Data Source

[Journal Article] 食塩と高血圧研究の最前線2015

Author(s)

Journal Title

Data Source

[Journal Article] 腎疾患とエピジェネティクス2013

Author(s)

Journal Title

Data Source

[Journal Article] 生活習慣病とエピジェネティクス2013

Author(s)

Journal Title

Data Source

[Journal Article] 2013. Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive hypertension2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rac1とRAAS2013

Author(s)

Journal Title

Data Source

KAWARAZAKI Wakako 河原崎和歌子

[Presentation] Eplerenoneは塩分過剰摂取によるRA系阻害抵抗性腎障害を抑制する−EVALUATE試験サブ解析−2015