Kawarazaki Wakako 河原崎和歌子

… Alternative Names

Researcher Number	50424594
Other IDs
Affiliation (Current)	2021: 東京大学, 先端科学技術研究センター, 特任准教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 東京大学, 先端科学技術研究センター, 特任助教 2013 – 2017: 東京大学, 先端科学技術研究センター, 特任研究員 2015: 東京大学, 先端科学技術研究センター, 研究員 2015: 東京大学, 先端科学技術研究センター臨床エピジェネティクス講座, 特任研究員
Review Section/Research Field	Principal Investigator Kidney internal medicine / Basic Section 53020:Cardiology-related Except Principal Investigator Kidney internal medicine
Keywords	Principal Investigator 食塩感受性 / ナトリウム輸送体 / 食塩感受性高血圧 / 肥満 / 高血圧 / Klotho / 高血圧症 / 腎臓 / エピジェネティクス / ミネラロコルチコイド受容体 … More Except Principal Investigator エピジェネティクス / ミネラルコルチコイド / 糖尿病性腎症 / DNAメチル化 / アンジオテンシン / 近位尿細管 / ミネラルコルチコイド受容体 / 鉱質コルチコイド / 糖質コルチコイド / DOHaD / 食塩感受性高血圧 / 内科 / アルドステロン / コルチゾール / 高血圧 / 腎障害 Less

加齢に伴う食塩感受性高血圧発症機序の解明と新規治療戦略Principal InvestigatorOngoing
- Principal Investigator
  
  河原崎和歌子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Tokyo
Exploring the mechanism of obesity related abnormal adipokine - induced hypertension and renal impairmentPrincipal Investigator
- Principal Investigator
  
  Kawarazaki Wakako
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunctionOngoing
- Principal Investigator
  
  藤田敏郎
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索
- Principal Investigator
  
  藤田敏郎
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Exploration of epigenetic abnormality of diabetic kidney disease for novel therapy
- Principal Investigator
  
  Marumo Takeshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Exploring the Epigenetic Abnormalities of Mineralocorticoid Receptor Activation in Salt-sensitive Hypertension and NephropathyPrincipal Investigator
- Principal Investigator
  
  KAWARAZAKI Wakako
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation

[Journal Article] Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency2020
- Author(s)
  Kawarazaki W, Mizuno R, Nishimoto M, Ayuzawa N, Hirohama D, Ueda K, Kawakami-Mori F, Oba S, Marumo T and Fujita.
- Journal Title
  
  J Clin invest
  
  Volume: -
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08028
[Journal Article] Mineralocorticoid Receptor Blockade Suppresses Dietary Salt-Induced ACEI/ARB-resistant Albuminuria in Non-Diabetic Hypertension: A Sub-Analysis of Evaluate Study2019
- Author(s)
  Nishimoto Mitsuhiro、Ohtsu Hiroshi、Marumo Takeshi、Kawarazaki Wakako、Ayuzawa Nobuhiro、Ueda Kohei、Hirohama Daigoro、Kawakami-Mori Fumiko、Shibata Shigeru、Nagase Miki、Isshiki Masashi、Oba Shigeyoshi、Shimosawa Tatsuo、Fujita Toshiro
- Journal Title
  
  Hypertens Res.
  
  Volume: 42 Pages: 514-521
- DOI
  10.1038/s41440-018-0201-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06841, KAKENHI-PROJECT-18K12134, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-17K16075, KAKENHI-PROJECT-17K09736, KAKENHI-PROJECT-18K19533
[Journal Article] Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.2018
- Author(s)
  Uchida K, Tanaka Y, Ichikawa H, Watanabe M, Mitani S, Morita K, Fujii H, Ishikawa M, Yoshino G, Okinaga H, Nagae G, Aburatani H, Ikeda Y, Susa T, Tamamori-Adachi M, Fukusato T, Uozaki H, Okazaki T, Iizuka M
- Journal Title
  
  Am J Physiol Renal Physiol
  
  Volume: 314
- DOI
  10.1152/ajprenal.00390.2017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-16K15494, KAKENHI-PROJECT-15K19443, KAKENHI-PROJECT-17K16074
[Journal Article] Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells2018
- Author(s)
  Oba Shigeyoshi、Ayuzawa Nobuhiro、Nishimoto Mitsuhiro、Kawarazaki Wakako、Ueda Kohei、Hirohama Daigoro、Kawakami-Mori Fumiko、Shimosawa Tatsuo、Marumo Takeshi、Fujita Toshiro
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 16338-16338
- DOI
  10.1038/s41598-018-34612-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19533, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-17K16074
[Journal Article] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2018
- Author(s)
  Hirohama D, Ayuzawa N, Ueda K, Nishimoto M, Kawarazaki W, Watanabe A, Shimosawa T, Marumo T, Shibata S, Fujita T
- Journal Title
  
  Journal of the American Society of Nephrology
  
  Volume: 29 Pages: 57-68
- DOI
  10.1681/asn.2017030243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-17K16074, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-15H04837, KAKENHI-PROJECT-16K15494, KAKENHI-PROJECT-15K19443, KAKENHI-PROJECT-26860546
[Journal Article] Aberrant DNA methylation of hypothalamic angiotensin receptor in prenatal programmed hypertension2018
- Author(s)
  Kawakami-Mori Fumiko、Nishimoto Mitsuhiro、Reheman Latapati、Kawarazaki Wakako、Ayuzawa Nobuhiro、Ueda Kohei、Hirohama Daigoro、Kohno Daisuke、Oba Shigeyoshi、Shimosawa Tatsuo、Marumo Takeshi、Fujita Toshiro
- Journal Title
  
  JCI Insight
  
  Volume: 3 Pages: 95625-95625
- DOI
  10.1172/jci.insight.95625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19533, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-17K16074
[Journal Article] アルドステロンブロッカーのエビデンスと今後の期待される展開2017
- Author(s)
  河原崎和歌子
- Journal Title
  
  血圧
  
  Volume: 24 Pages: 489-497
- Data Source
  KAKENHI-PROJECT-15K19443
[Journal Article] Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent HypertensionNovelty and Significance2017
- Author(s)
  Ueda K, Nishimoto M, Hirohama D, Ayuzawa N, Kawarazaki W, Watanabe A, Shimosawa T, Loffing J, Zhang MZ, Marumo T, Fujita T
- Journal Title
  
  Hypertension
  
  Volume: 70 Pages: 111-118
- DOI
  10.1161/hypertensionaha.116.08966
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16074, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-15K19443
[Journal Article] The Role of Aldosterone in Obesity-Related Hypertension.2016
- Author(s)
  Wakako Kawarazaki and Toshiro Fujita.
- Journal Title
  
  American Journal of Hypertension
  
  Volume: 29 Pages: 415-423
- DOI
  10.1093/ajh/hpw003
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K19443
[Journal Article] Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury. Hypertension2016
- Author(s)
  Nobuhiro Ayuzawa, Miki Nagase, Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Takeshi Marumo, Atsu Aiba, Takayuki Sakurai, Takayuki Shindo, Toshiro Fujita
- Journal Title
  
  Hypertension.
  
  Volume: 67 Pages: 99-106
- DOI
  10.1161/hypertensionaha.115.06054
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860546, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-25461230, KAKENHI-PROJECT-26670153, KAKENHI-PROJECT-26670426, KAKENHI-PROJECT-26670427, KAKENHI-PROJECT-26293085
[Journal Article] 食塩と高血圧研究の最前線2015
- Author(s)
  河原崎和歌子、藤田敏郎
- Journal Title
  
  実験医学増刊　先制医療
  
  Volume: 33 Pages: 72-78
- Data Source
  KAKENHI-PROJECT-25860669
[Journal Article] Rac1-mediated activation of mineralocorticoid receptor in pressure overload-induced cardiac injury2015
- Author(s)
  Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Sakurai T, Shindo T, Fujita T
- Journal Title
  
  Hypertension
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02538
[Journal Article] Diabetes Induces Aberrant DNA Methylation in the Proximal Tubules of the Kidney2015
- Author(s)
  Marumo T, Yagi S, Kawarazaki W, Nishimoto M, Ayuzawa N, Watanabe A, Ueda K, Hirahashi J, Hishikawa K, Sakurai H, Shiota K, Fujita T.
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 印刷中 Pages: 2333-2397
- DOI
  10.1681/asn.2014070665
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25860669, KAKENHI-PROJECT-15H03001, KAKENHI-PROJECT-25461230, KAKENHI-PROJECT-26670426
[Journal Article] 生活習慣病とエピジェネティクス2013
- Author(s)
  河原崎和歌子、藤田敏郎
- Journal Title
  
  Nephrology Frontier
  
  Volume: 12 Pages: 308-313
- Data Source
  KAKENHI-PROJECT-25860669
[Journal Article] 腎疾患とエピジェネティクス2013
- Author(s)
  河原崎和歌子、藤田敏郎
- Journal Title
  
  Nephrology Frontier
  
  Volume: 12 Pages: 408-413
- Data Source
  KAKENHI-PROJECT-25860669
[Journal Article] Rac1とRAAS2013
- Author(s)
  河原崎和歌子、長瀬美樹
- Journal Title
  
  Angiotensin　Research
  
  Volume: 10 Pages: 226-233
- Data Source
  KAKENHI-PROJECT-25860669
[Journal Article] Aberrant Rac1-mineralocorticoid receptor pathways in salt-sensitive hypertension.2013
- Author(s)
  Kawarazaki, W., and Fujita, T
- Journal Title
  
  Clin Exp Pharmacol Physiol.
  
  Volume: 40 Pages: 929-936
- DOI
  10.1111/1440-1681.12177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229012, KAKENHI-PROJECT-24659410, KAKENHI-PROJECT-25860669
[Presentation] 「老化に伴う食塩感受性高血圧発症機序の解明」2019
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 森典子, 大庭成喜, 丸茂丈史, 藤田敏郎.
- Organizer
  第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08028
[Presentation] Two distinct regulations of pendrin by mineralocorticoid receptor in distal nephron2019
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Wakako Kawarazaki, Takeshi Marumo, Toshiro Fujita
- Organizer
  The 44th International Aldosterone Conference,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 「加齢に伴う食塩感受性高血圧発症機序の解明」2019
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 大庭成喜, 丸茂丈史, 藤田敏郎.
- Organizer
  第42回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-18K08028
[Presentation] 「加齢に伴う食塩感受性高血圧発症機序の解明」2019
- Author(s)
  河原崎和歌子, 水野理介, 西本光宏, 鮎澤信宏, 広浜大五郎, 大庭成喜, 丸茂丈史, 藤田敏郎
- Organizer
  第29回日本循環薬理学会・第55回高血圧関連疾患モデル学会合同学会
- Data Source
  KAKENHI-PROJECT-18K08028
[Presentation] Vascular Rho Kinase and RAS in Ageing-Associated Salt-Sensitive Hypertension2018
- Author(s)
  Wakako Kawarazaki
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症におけるKlotho-Wnt-Rho pathwayの関与2018
- Author(s)
  河原崎和歌子
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-18K08028
[Presentation] 加齢に伴う食塩感受性高血圧発症におけるKlotho-Wnt-Rho pathwayの関与2018
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、森典子、大庭成喜、丸茂丈史、藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] "Vascular Rho Kinase and RAS in Ageing-Associated Salt-Sensitive Hypertension"2018
- Author(s)
  Wakako Kawarazaki
- Organizer
  Gordon Research Conference 2018 Angiotensin
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19443
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第54回高血圧関連疾患学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Mineralocorticoid receptor in renal intercalated cells mediates RAAS-driven pendrin regulation to maintain fluid homeostasis2018
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Wakako Kawarazaki, Tastuo Shimosawa, Takeshi Marumo, Toshiro Fujita.
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2018
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎臓特異的DNAメチル化を尿中マーカーとした糖尿病性腎症の尿細管障害診断法2018
- Author(s)
  丸茂丈史、下澤達雄、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、佐藤敦久、渥美義仁、星野純一、乳原善文、藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・水電解質代謝調節作用に関する検討2018
- Author(s)
  広浜大五郎、鮎澤信宏、上田浩平、西本光宏、河原崎和歌子、下澤達雄、丸茂丈史、柴田茂、藤田敏郎
- Organizer
  第22回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Mineralocorticoid receptor in renal intercalated cells mediates pendrin regulation by renin-angiotensin-aldosterone system to maintain fluid homeostasis2018
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Wakako Kawarazaki, Tastuo Shimosawa, Takeshi Marumo, Toshiro Fujita
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症機序の検討2018
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、丸茂丈史、藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症機序の検討2018
- Author(s)
  河原崎和歌子
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08028
[Presentation] 腎間在細胞ミネラロコルチコイド受容体欠損マウスを用いたPendrin制御機構の解析2017
- Author(s)
  鮎澤信宏、上田浩平、広浜大五郎、西本光宏、河原崎和歌子、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 食塩感受性高血圧の内分泌学的および腎生理学的検討2017
- Author(s)
  西本光宏、上田浩平、河原崎和歌子、水野理介、森典子、渡邉篤史、広浜大五郎、鮎澤信宏、大庭成喜、丸茂丈史、藤田敏郎
- Organizer
  第90回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢と食塩感受性高血圧～抗加齢因子Klothoの発現低下はRhoA活性化による血管収縮を惹起する～2017
- Author(s)
  河原崎和歌子
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15K19443
[Presentation] 腎臓特異的な11beta HSD2活性低下による高血圧発症機序の解析2017
- Author(s)
  上田浩平、西本光宏、広浜大五郎、鮎澤信宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎pendrinの発現機構と血圧調節における役割の解明2017
- Author(s)
  広浜大五郎、鮎澤信宏、上田浩平、西本光宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、柴田茂、藤田敏郎
- Organizer
  第21回心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] PendrinとNCC発現調節におけるアンジオテンシンIIとアルドステロンの異なる役割2017
- Author(s)
  広浜大五郎、柴田茂、上田浩平、鮎澤信宏、西本光宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病腎メサンギウム細胞のDNAメチル化異常によるTGFｂ発現増加をRA系阻害薬は抑制する2017
- Author(s)
  大庭成喜、広浜大五郎、鮎澤信宏、西本光宏、河原崎和歌子、上田浩平、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 特異的DNAメチル化signatureを用いた糖尿病性腎症の尿細管障害診断2017
- Author(s)
  丸茂丈史、下澤達雄、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、星野純一、乳原善文、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 抗加齢因子Klothoの発現低下は腎mTORC1の活性化を介して食塩感受性高血圧を惹起する2017
- Author(s)
  河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2017
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto,Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] ミネラロコルチコイド受容体活性化による食塩感受性高血圧と臓器障害発症機序の検討2017
- Author(s)
  河原崎和歌子
- Organizer
  第21回心血管内分泌代謝学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病性腎症でエピゲノム異常をきたす核内受容体PXRは腎糖新生を調整する2017
- Author(s)
  渡邉篤史丸茂丈史河原崎和歌子西本光宏鮎澤信宏広浜大五郎上田浩平熊谷裕生藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 抗加齢因子Klothoの発現低下は腎mTORC1の活性化を介して食塩感受性高血圧を惹起する2017
- Author(s)
  河原崎和歌子
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15K19443
[Presentation] ミネラロコルチコイド受容体活性化による食塩感受性高血圧と臓器障害発症機序の検討2017
- Author(s)
  河原崎和歌子
- Organizer
  CVMW2017心血管代謝週間
- Invited
- Data Source
  KAKENHI-PROJECT-15K19443
[Presentation] 抗加齢因子Klotho発現低下に伴う食塩感受性高血圧発症機序の解明2017
- Author(s)
  河原崎和歌子
- Organizer
  第59回日本腎臓学会学術総会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Year and Date
  2017-06-17
- Data Source
  KAKENHI-PROJECT-15K19443
[Presentation] 加齢と食塩感受性高血圧～抗加齢因子Klothoの発現低下はRhoA活性化による血管収縮を惹起する～2017
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Systemic effect of renal 11beta-HSD2 deficiency on blood pressure regulation2017
- Author(s)
  Kohei Ueda, Mitsuhiro Nishimoto, Daigoro Hirohama, Nobuhiro Ayuzawa, Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Johannes Loffing, Ming-Zhi Zhang, Takeshi Marumo, Toshiro Fujita
- Organizer
  AHA Council on Hypertension American Society of Hypertension Joint Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] The mechanism of blood pressure elevation in distal nephron-specific Hsd11b2 knockout mice2016
- Author(s)
  Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Nobuhiro Ayuzawa, Daigoro Hirohama, Atsushi Watanabe, Takeshi Marumo, Toshiro Fujita
- Organizer
  The 41st International Aldosterone Conference Aldosterone and Mineralocorticoids
- Place of Presentation
  Boston, USA
- Year and Date
  2016-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] PendrinとNCC発現調節におけるアンジオテンシンIIとアルドステロンの異なる役割2016
- Author(s)
  広浜大五郎, 柴田茂, 上田浩平, 鮎澤信宏, 西本光宏, 河原崎和歌子, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 抗加齢因子Klotho発現低下に伴う食塩感受性高血圧発症機序の解明2016
- Author(s)
  河原崎和歌子, 丸茂丈史, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 渡邉篤史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 間在細胞EGFP標識マウスを用いた間在細胞分取・解析法の確立2016
- Author(s)
  鮎澤信宏, 上田浩平, 広浜大五郎, 西本光宏, 河原崎和歌子, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Epigenetic abnormalities underlie increased expression of nuclear receptor PXR in diabetic kidney disease2015
- Author(s)
  Atsushi Watanabe, Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Hiroo Kumagai, Toshiro Fujita
- Organizer
  Kidney Week 2015 ASN Annual Meeting
- Place of Presentation
  San Diego Convention Center, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 遠位ネフロン特異的Rac1欠損マウスを用いたRac1-ミネラロコルチコイド受容体（MR）経路の解析2015
- Author(s)
  鮎澤信宏、上田浩平、広浜大五郎、西本光宏、河原崎和歌子、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Eplerenoneは塩分過剰摂取によるRA系阻害抵抗性腎障害を抑制する−EVALUATE試験サブ解析−2015
- Author(s)
  西本光宏、大津洋、丸茂丈史、河原崎和歌子、鮎澤信宏、上田浩平、広浜大五郎、渡邉篤史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Epigenetic abnormalities underlie increased expression of nuclear receptor PXR in diabetic kidney disease2015
- Author(s)
  Atsushi Watanabe, Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Hiroo Kumagai, Toshiro Fujita
- Organizer
  Kidney Week 2015 ASN Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病性腎症にみられるエピジェネティック異常は血糖治療に抵抗性を示す2015
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、渡邉篤史、上田浩平、菱川慶一、櫻井裕之、藤田敏郎
- Organizer
  第88回日本内分泌学会学術総会
- Place of Presentation
  ホテルニューオータニ　東京
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 近位尿細管の核内受容体Pxrは糖尿病腎症でエピゲノム変化を介して発現が更新する2015
- Author(s)
  渡邉篤史　丸茂丈史　河原崎和歌子　西本光宏　鮎澤信宏　広浜大五郎　上田浩平　熊谷裕生　藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 糖尿病性腎症にみられる治療抵抗性エピジェネティック異常2014
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、渡邉篤史、菱川慶一、櫻井裕之、藤田敏郎
- Organizer
  第57回日本腎臓学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-07-04
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 糖尿病による腎臓近位尿細管DNAメチル化異常2014
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、渡邉篤史、早川晃司、廣澤瑞子、塩田邦郎、藤田敏郎
- Organizer
  第8回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Year and Date
  2014-05-26
- Data Source
  KAKENHI-PROJECT-25461230
[Presentation] 糖尿病性腎症にみられる治療抵抗性DNAメチル化異常2014
- Author(s)
  丸茂丈史、八木慎太郎、河原崎和歌子、西本光宏、鮎澤信宏、上田浩平、渡邉篤史、藤田敏郎
- Organizer
  第6回腎疾患と高血圧研究会
- Place of Presentation
  東京
- Year and Date
  2014-07-12
- Data Source
  KAKENHI-PROJECT-25461230

1. Marumo Takeshi (70265817)

# of Collaborated Projects: 3 results

# of Collaborated Products: 44 results
2. 藤田敏郎 (10114125)

# of Collaborated Projects: 2 results

# of Collaborated Products: 39 results
3. 西本光宏 (90646572)

# of Collaborated Projects: 2 results

# of Collaborated Products: 37 results
4. 鮎澤信宏 (50459517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 37 results
5. 広浜大五郎 (20749353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 35 results
6. 柴田茂 (60508068)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
7. 下澤達雄 (90231365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
8. 大庭成喜 (80361492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
9. 上田浩平 (80735697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 32 results
10. 森典子 (80431857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
11. HISHIKAWA Keiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 永江玄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 桜井敬之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 新藤隆行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 長瀬美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 大津洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawarazaki Wakako 河原崎 和歌子

KAWARAZAKI Wakako 河原崎 和歌子

Research Projects

Research Products

Co-Researchers

加齢に伴う食塩感受性高血圧発症機序の解明と新規治療戦略Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring the mechanism of obesity related abnormal adipokine - induced hypertension and renal impairmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunctionOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of epigenetic abnormality of diabetic kidney disease for novel therapy

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring the Epigenetic Abnormalities of Mineralocorticoid Receptor Activation in Salt-sensitive Hypertension and NephropathyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency2020

Author(s)

Journal Title

Data Source

[Journal Article] Mineralocorticoid Receptor Blockade Suppresses Dietary Salt-Induced ACEI/ARB-resistant Albuminuria in Non-Diabetic Hypertension: A Sub-Analysis of Evaluate Study2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Aberrant DNA methylation of hypothalamic angiotensin receptor in prenatal programmed hypertension2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アルドステロンブロッカーのエビデンスと今後の期待される展開2017

Author(s)

Journal Title

Data Source

[Journal Article] Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent HypertensionNovelty and Significance2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Role of Aldosterone in Obesity-Related Hypertension.2016

Kawarazaki Wakako 河原崎和歌子

KAWARAZAKI Wakako 河原崎和歌子