Nishimoto Mitsuhiro 西本光宏

Researcher Number	90646572
Other IDs
Affiliation (Current)	2026: 国際医療福祉大学, 国際医療福祉大学三田病院, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 国際医療福祉大学, 国際医療福祉大学三田病院, 教授 2019 – 2023: 国際医療福祉大学, 国際医療福祉大学三田病院, 准教授 2019: 東京大学, 先端科学技術研究センター, 特任講師 2018: 東京大学, 先端科学技術研究センター, 特任助教 2014 – 2017: 東京大学, 先端科学技術研究センター, 特任研究員 2015: 東京大学, 先端科学技術研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine / Cardiovascular medicine Except Principal Investigator Kidney internal medicine / Basic Section 53040:Nephrology-related
Keywords	Principal Investigator 高血圧 / 食塩感受性高血圧 / 糖質コルチコイド / 血圧 / バイオマーカー / DNAメチル化 / エピジェネティクス / 慢性腎臓病 / 妊娠時ストレス / DOHaD … More / グルココルチコイド / エピジェネティックス / 胎児期 / 鉱質コルチコイド受容体 / 糖質コルチコイド受容体 / 血圧日内変動 / ナトリウム輸送体 / 日内変動 / 血管内皮細胞 / カルシウムシグナル / 血管内皮機能 / 動脈硬化 / カルシウム / 血管内皮 … More Except Principal Investigator エピジェネティクス / 高血圧 / ミネラルコルチコイド / 生活習慣病 / エピジェネティック / DNAメチル化 / 近位尿細管 / 慢性腎臓病 / DNAメチル化異常 / 糖尿病性腎症 / 高血圧学 / コルチゾール / 内科 / DOHaD / ミネラルコルチコイド受容体 / 加齢 / 糖尿病性腎臓病 / 食塩感受性高血圧 / アルドステロン / 腎臓病 / 環境因子 / 糖質コルチコイド / 鉱質コルチコイド / ミネラロコルチコイド受容体 / 腎障害 Less

Development of the urine test for the diagnosis of the activity of chronic kidney disease by the epigenetic methodPrincipal Investigator
- Principal Investigator
  
  西本光宏
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  International University of Health and Welfare
Exploration of epigenetic mechanisms underlying development of life style-related disease
- Principal Investigator
  
  Marumo Takeshi
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  International University of Health and Welfare
Exploratory research about the mechanism of prenatal programmed hypertensionPrincipal Investigator
- Principal Investigator
  
  Nishimoto Mitsuhiro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  International University of Health and Welfare
  The University of Tokyo
The role of glucocorticoid in renal tubules modulating diurnal change in blood pressurePrincipal Investigator
- Principal Investigator
  
  Nishimoto Mitsuhiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索
- Principal Investigator
  
  FUJITA Toshiro
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunction
- Principal Investigator
  
  FUJITA Toshiro
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo
The role of STIM1 in vascular endothelial cells in the progression of atherosclerosisPrincipal Investigator
- Principal Investigator
  
  Nishimoto Mitsuhiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes2024
- Author(s)
  Marumo T, Yoshida N, Inoue N, Yamanouchi M, Ubara Y, Urakami S, Fujii T, Takazawa Y, Ohashi K, Kawarazaki W, Nishimoto M, Ayuzawa N, Hirohama D, Nagae G, Fujimoto M, Arai E, Kanai Y, Hoshino J, Fujita T
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 327 Issue: 3 Pages: F397-F411
- DOI
  10.1152/ajprenal.00124.2024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24H00065, KAKENHI-PROJECT-23K21431, KAKENHI-PROJECT-20K08627, KAKENHI-PROJECT-22K06947, KAKENHI-PROJECT-23K07680, KAKENHI-PROJECT-23K07703, KAKENHI-PROJECT-23K07721
[Journal Article] Activation of Rac1-mineralocorticoid receptor pathway contributes to renal injury in salt-loaded db/db mice.2021
- Author(s)
  Hirohama D, Nishimoto M, Ayuzawa N, Kawarazaki W, Fujii W, Oba S, Shibata S, Marumo T, Fujita T.
- Journal Title
  
  Hypertension
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05788
[Journal Article] PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation2020
- Author(s)
  Hirohama Daigoro、Kawarazaki Wakako、Nishimoto Mitsuhiro、Ayuzawa Nobuhiro、Marumo Takeshi、Shibata Shigeru、Fujita Toshiro
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 21 Issue: 12 Pages: 4433-4433
- DOI
  10.3390/ijms21124433
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08672, KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-19H03678
[Journal Article] 医学と医療の最前線胎児期から成人にいたる食塩感受性高血圧2020
- Author(s)
  西本光宏、藤田敏郎
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 109 Pages: 2191-2198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08672
[Journal Article] 特集いま知っておきたい!　内科最新トピックス巻頭トピックス選択的ミネラルコルチコイド受容体拮抗薬の使い方2020
- Author(s)
  西本光宏、下澤達雄
- Journal Title
  
  内科
  
  Volume: 126 Pages: 363-366
- Data Source
  KAKENHI-PROJECT-19K08672
[Journal Article] Methylation pattern of urinary DNA as a marker of kidney function decline in diabetes.2020
- Author(s)
  Marumo T, Hoshino J, Kawarazaki W, Nishimoto M, Ayuzawa N, Hirohama D, Yamanouchi M, Ubara Y, Okaneya T, Fujii T, Yuki K, Atsumi Y, Sato A, Arai E, Kanai Y, Shimosawa T, Fujita T.
- Journal Title
  
  BMJ Open Diabetes Res Care
  
  Volume: 8 Issue: 1 Pages: e001501-e001501
- DOI
  10.1136/bmjdrc-2020-001501
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07444, KAKENHI-PROJECT-19K08672, KAKENHI-PROJECT-20K08627, KAKENHI-PROJECT-20K21596, KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-15H05788
[Journal Article] Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency2020
- Author(s)
  Kawarazaki Wakako、Mizuno Risuke、Nishimoto Mitsuhiro、Ayuzawa Nobuhiro、Hirohama Daigoro、Ueda Kohei、Kawakami-Mori Fumiko、Oba Shigeyoshi、Marumo Takeshi、Fujita Toshiro
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Pages: 4152-4166
- DOI
  10.1172/jci134431
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08672, KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-18K08028, KAKENHI-PROJECT-19K22984
[Journal Article] Two Mineralocorticoid Receptor-Mediated Mechanisms of Pendrin Activation in Distal Nephrons.2020
- Author(s)
  Ayuzawa N, Nishimoto M, Ueda K, Hirohama D, Kawarazaki W, Shimosawa T, Marumo T, Fujita T.
- Journal Title
  
  J Am Soc Nephrol.
  
  Volume: 31 Issue: 4 Pages: 748-764
- DOI
  10.1681/asn.2019080804
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17732, KAKENHI-PROJECT-18K19533, KAKENHI-PROJECT-18K15969, KAKENHI-PROJECT-19K08672, KAKENHI-PROJECT-20K08585, KAKENHI-PROJECT-20K21596, KAKENHI-PROJECT-15H05788
[Journal Article] Mineralocorticoid receptor blockade suppresses dietary salt-induced ACEI/ARB-resistant albuminuria in non-diabetic hypertension: a sub-analysis of evaluate study2019
- Author(s)
  Nishimoto Mitsuhiro、Ohtsu Hiroshi、Marumo Takeshi、Kawarazaki Wakako、Ayuzawa Nobuhiro、Ueda Kohei、Hirohama Daigoro、Kawakami-Mori Fumiko、Shibata Shigeru、Nagase Miki、Isshiki Masashi、Oba Shigeyoshi、Shimosawa Tatsuo、Fujita Toshiro
- Journal Title
  
  Hypertension Research
  
  Volume: 42 Issue: 4 Pages: 514-521
- DOI
  10.1038/s41440-018-0201-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06841, KAKENHI-PROJECT-18K12134, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-17K16075, KAKENHI-PROJECT-17K09736, KAKENHI-PROJECT-18K19533
[Journal Article] Aberrant DNA methylation of pregnane X receptor underlies metabolic gene alterations in the diabetic kidney2018
- Author(s)
  Uchida K, Tanaka Y, Ichikawa H, Watanabe M, Mitani S, Morita K, Fujii H, Ishikawa M, Yoshino G, Okinaga H, Nagae G, Aburatani H, Ikeda Y, Susa T, Tamamori-Adachi M, Fukusato T, Uozaki H, Okazaki T, Iizuka M
- Journal Title
  
  American Journal of Physiology-Renal Physiology
  
  Volume: 314 Issue: 4 Pages: F551-F560
- DOI
  10.1152/ajprenal.00390.2017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08987, KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-16K15494, KAKENHI-PROJECT-15K19443, KAKENHI-PROJECT-17K16074
[Journal Article] Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells2018
- Author(s)
  Oba Shigeyoshi、Ayuzawa Nobuhiro、Nishimoto Mitsuhiro、Kawarazaki Wakako、Ueda Kohei、Hirohama Daigoro、Kawakami-Mori Fumiko、Shimosawa Tatsuo、Marumo Takeshi、Fujita Toshiro
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 16338-16338
- DOI
  10.1038/s41598-018-34612-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19533, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-17K16074
[Journal Article] Stromal Interaction Molecule 1 modulates blood pressure via NO production in vascular endothelial cells2018
- Author(s)
  Nishimoto M, Mizuno R, Fujita T, Isshiki M
- Journal Title
  
  Hypertens Res in press
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05788
[Journal Article] Aldosterone is essential for angiotensin II-induced upregulation of pendrin.2018
- Author(s)
  Hirohama D, Ayuzawa N, Ueda K, Nishimoto M, Kawarazaki W, Watanabe A, Shimosawa T, Marumo T, Shibata S, Fujita T
- Journal Title
  
  J Am Soc Nephrol
  
  Volume: 29 Issue: 1 Pages: 57-68
- DOI
  10.1681/asn.2017030243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-17K16074, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-15H04837, KAKENHI-PROJECT-16K15494, KAKENHI-PROJECT-15K19443, KAKENHI-PROJECT-26860546
[Journal Article] Stromal interaction molecule 1 modulates blood pressure via NO production in vascular endothelial cells2018
- Author(s)
  Nishimoto Mitsuhiro、Mizuno Risuke、Fujita Toshiro、Isshiki Masashi
- Journal Title
  
  Hypertension Research
  
  Volume: 41 Issue: 7 Pages: 506-514
- DOI
  10.1038/s41440-018-0045-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05788
[Journal Article] Aberrant DNA methylation of hypothalamic angiotensin receptor in prenatal programmed hypertension2018
- Author(s)
  Kawakami-Mori Fumiko、Nishimoto Mitsuhiro、Reheman Latapati、Kawarazaki Wakako、Ayuzawa Nobuhiro、Ueda Kohei、Hirohama Daigoro、Kohno Daisuke、Oba Shigeyoshi、Shimosawa Tatsuo、Marumo Takeshi、Fujita Toshiro
- Journal Title
  
  JCI Insight
  
  Volume: 3 Issue: 21 Pages: 95625-95625
- DOI
  10.1172/jci.insight.95625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K19533, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-16K15466, KAKENHI-PROJECT-17K16074
[Journal Article] Renal Dysfunction Induced by Kidney-Specific Gene Deletion of Hsd11b2 as a Primary Cause of Salt-Dependent Hypertension2017
- Author(s)
  Ueda K, Nishimoto M, Hirohama D, Ayuzawa N, Kawarazaki W, Watanabe A, Shimosawa T, Loffing J, Zhang MZ, Marumo T, Fujita T
- Journal Title
  
  Hypertension
  
  Volume: 70 Issue: 1 Pages: 111-118
- DOI
  10.1161/hypertensionaha.116.08966
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16074, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-15K19443
[Journal Article] Rac1-Mediated Activation of Mineralocorticoid Receptor in Pressure Overload-Induced Cardiac Injury2016
- Author(s)
  Nobuhiro Ayuzawa, Miki Nagase, Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Takeshi Marumo, Atsu Aiba, Takayuki Sakurai, Takayuki Shindo, Toshiro Fujita
- Journal Title
  
  Hypertension
  
  Volume: 67 Issue: 1 Pages: 99-106
- DOI
  10.1161/hypertensionaha.115.06054
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860546, KAKENHI-PROJECT-15H05788, KAKENHI-PROJECT-25461230, KAKENHI-PROJECT-26670153, KAKENHI-PROJECT-26670426, KAKENHI-PROJECT-26670427, KAKENHI-PROJECT-26293085
[Journal Article] Rac1-mediated activation of mineralocorticoid receptor in pressure overload-induced cardiac injury2015
- Author(s)
  Ayuzawa N, Nagase M, Ueda K, Nishimoto M, Kawarazaki W, Marumo T, Sakurai T, Shindo T, Fujita T
- Journal Title
  
  Hypertension
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02538
[Presentation] 糖尿病性腎症で生じる近位尿細管脱分化に伴うDNAメチル化異常2024
- Author(s)
  丸茂丈史、吉田修土、井上典子、山内真之、乳原善文、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、星野純一、藤田敏郎
- Organizer
  第67回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-23K07721
[Presentation] 糖尿病性腎症で生じる近位尿細管脱分化に伴うDNAメチル化異常2024
- Author(s)
  丸茂丈史、吉田修土、井上典子、山内真之、乳原善文、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、星野純一、藤田敏郎
- Organizer
  第67回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08627
[Presentation] 糖尿病性腎症にみられる糖新生経路のエピジェネティックな抑制2023
- Author(s)
  丸茂丈史、吉田修土、山内真之、井上典子、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、乳原善文、星野純一、藤田敏郎
- Organizer
  第66回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08627
[Presentation] 糖尿病性腎症にみられる糖新生経路のエピジェネティックな抑制2023
- Author(s)
  丸茂丈史、吉田修土、山内真之、井上典子、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、乳原善文、星野純一、藤田敏郎
- Organizer
  第66回日本腎臓学会学術総会 2023/06/11 横浜
- Data Source
  KAKENHI-PROJECT-23K07721
[Presentation] 糖尿病にみられるeGFRと関連する腎臓DNAメチル化異常2022
- Author(s)
  丸茂丈史、星野純一、山内真之、井上典子、乳原善文、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、藤田敏郎
- Organizer
  第65回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08627
[Presentation] 高血圧治療におけるMR抑制の意義2020
- Author(s)
  西本光宏
- Organizer
  第15回Vascular Biology Innovationに関する研究助成　第15回研究発表会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 高血圧発症機序の解明ー血管内皮機能調節と食塩感受性規定因子の研究ー2020
- Author(s)
  西本　光宏
- Organizer
  第15回Vascular Biology Innovationに関する研究助成研究発表会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08672
[Presentation] ポドサイトRac1-ミネラルコルチコイド受容体(MR)系活性化は糖尿病性腎臓病進展に寄与する2020
- Author(s)
  広浜大五郎, 西本光宏, 鮎澤信宏, 河原崎和歌子, 大庭成喜, 丸茂丈史, 藤田敏郎
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08627
[Presentation] 妊娠時低栄養による食塩感受性高血圧のエピジェネティック機序2020
- Author(s)
  西本光宏
- Organizer
  第63回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 水電解質領域および尿細管機能の基礎研究:最近の進歩と臨床へのつながり妊娠時低栄養による食塩感受性高血圧のエピジェネティック機序2020
- Author(s)
  [西本光宏]
- Organizer
  第63回日本腎臓学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-19K08672
[Presentation] 妊娠時低栄養による食塩感受性高血圧発症機序2020
- Author(s)
  西本　光宏
- Organizer
  日本栄養・食糧学会関東支部
- Invited
- Data Source
  KAKENHI-PROJECT-19K08672
[Presentation] 糖尿病性腎症に生じたメタボリックメモリー関連遺伝子のDNAメチル化異常2020
- Author(s)
  丸茂丈史、星野純一、山内真之、乳原善文、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、藤田敏郎
- Organizer
  第63回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08627
[Presentation] 妊娠時ストレスによる食塩感受性高血圧発症機序の解明2019
- Author(s)
  西本光宏、森典子、広浜大五郎、鮎澤信宏、河原崎和歌子、丸茂丈史、藤田敏郎
- Organizer
  Vascular Biology Innovationに関する研究助成　第１４回研究発表会
- Data Source
  KAKENHI-PROJECT-19K08672
[Presentation] 妊娠時ストレスによる食塩感受性高血圧発症機序の解明2019
- Author(s)
  西本光宏
- Organizer
  第14回Vascular Biology Innovationに関する研究助成　第14回研究発表会（VBIC）
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 高血圧と食塩2019
- Author(s)
  西本光宏
- Organizer
  東京大学先端研カフェセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-19K08672
[Presentation] Two distinct regulations of pendrin by mineralocorticoid receptor in distal nephron2019
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Wakako Kawarazaki, Takeshi Marumo, Toshiro Fujita
- Organizer
  The 44th International Aldosterone Conference,
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Importance of dietary salt intake for the efficacy of mineralocorticoid receptor blockade against ACEI/ARB-resistant albuminuria; a sub-analysis of EVALUATE study2019
- Author(s)
  Mitsuhiro Nishimoto
- Organizer
  International Symposium of Aldosterone and Related Substances in Hypertension 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Stromal interaction molecule 1 modulates blood pressure via NO production in vascular endothelial cells2019
- Author(s)
  西本光宏
- Organizer
  第42回日本高血圧学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 食塩感受性高血圧の内分泌学的および腎生理学的検討2018
- Author(s)
  西本光宏
- Organizer
  第6回高血圧フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症におけるKlotho-Wnt-Rho pathwayの関与2018
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、森典子、大庭成喜、丸茂丈史、藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第54回高血圧関連疾患学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 食塩感受性高血圧の内分泌学的および腎生理学的検討2018
- Author(s)
  西本光宏
- Organizer
  第6回高血圧フォーラム in 金沢
- Invited
- Data Source
  KAKENHI-PROJECT-17K16075
[Presentation] Mineralocorticoid receptor in renal intercalated cells mediates RAAS-driven pendrin regulation to maintain fluid homeostasis2018
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Wakako Kawarazaki, Tastuo Shimosawa, Takeshi Marumo, Toshiro Fujita.
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2018
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  International Aldosterone Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎臓特異的DNAメチル化を尿中マーカーとした糖尿病性腎症の尿細管障害診断法2018
- Author(s)
  丸茂丈史、下澤達雄、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、佐藤敦久、渥美義仁、星野純一、乳原善文、藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・電解質代謝調節作用に関する役割2018
- Author(s)
  広浜大五郎, 鮎澤信宏, 西本光宏, 河原崎和歌子, 下澤達雄, 丸茂丈史, 柴田茂, 藤田敏郎
- Organizer
  第41回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Pendrinの血圧・水電解質代謝調節作用に関する検討2018
- Author(s)
  広浜大五郎、鮎澤信宏、上田浩平、西本光宏、河原崎和歌子、下澤達雄、丸茂丈史、柴田茂、藤田敏郎
- Organizer
  第22回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Mineralocorticoid receptor in renal intercalated cells mediates pendrin regulation by renin-angiotensin-aldosterone system to maintain fluid homeostasis2018
- Author(s)
  Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Daigoro Hirohama, Kohei Ueda, Wakako Kawarazaki, Tastuo Shimosawa, Takeshi Marumo, Toshiro Fujita
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 加齢に伴う食塩感受性高血圧発症機序の検討2018
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、丸茂丈史、藤田敏郎
- Organizer
  第61回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 食塩感受性高血圧の内分泌学的および腎生理学的検討2017
- Author(s)
  西本光宏、上田浩平、河原崎和歌子、水野理介、森典子、渡邉篤史、広浜大五郎、鮎澤信宏、大庭茂喜、丸茂丈史、藤田敏郎
- Organizer
  第90回日本内分泌学会学術総会　シンポジウム6
- Invited
- Data Source
  KAKENHI-PROJECT-17K16075
[Presentation] 腎間在細胞ミネラロコルチコイド受容体欠損マウスを用いたPendrin制御機構の解析2017
- Author(s)
  鮎澤信宏、上田浩平、広浜大五郎、西本光宏、河原崎和歌子、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 食塩感受性高血圧の内分泌学的および腎生理学的検討2017
- Author(s)
  西本光宏、上田浩平、河原崎和歌子、水野理介、森典子、渡邉篤史、広浜大五郎、鮎澤信宏、大庭成喜、丸茂丈史、藤田敏郎
- Organizer
  第90回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 高血圧とエピジェネティクス～妊娠時低栄養による食塩感受性高血圧発症の中枢神経機序の解明～2017
- Author(s)
  森典子、西本光宏、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎臓特異的な11beta HSD2活性低下による高血圧発症機序の解析2017
- Author(s)
  上田浩平、西本光宏、広浜大五郎、鮎澤信宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 腎pendrinの発現機構と血圧調節における役割の解明2017
- Author(s)
  広浜大五郎、鮎澤信宏、上田浩平、西本光宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、柴田茂、藤田敏郎
- Organizer
  第21回心血管内分泌代謝学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] PendrinとNCC発現調節におけるアンジオテンシンIIとアルドステロンの異なる役割2017
- Author(s)
  広浜大五郎、柴田茂、上田浩平、鮎澤信宏、西本光宏、河原崎和歌子、渡邉篤史、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病腎メサンギウム細胞のDNAメチル化異常によるTGFｂ発現増加をRA系阻害薬は抑制する2017
- Author(s)
  大庭成喜、広浜大五郎、鮎澤信宏、西本光宏、河原崎和歌子、上田浩平、下澤達雄、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 特異的DNAメチル化signatureを用いた糖尿病性腎症の尿細管障害診断2017
- Author(s)
  丸茂丈史、下澤達雄、河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、星野純一、乳原善文、藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 抗加齢因子Klothoの発現低下は腎mTORC1の活性化を介して食塩感受性高血圧を惹起する2017
- Author(s)
  河原崎和歌子、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第60回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Aldosterone is essential for angiotensin II-induced upregulation of pendrin2017
- Author(s)
  Daigoro Hirohama, Nobuhiro Ayuzawa, Kohei Ueda, Mitsuhiro Nishimoto,Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Takeshi Marumo, Shigeru Shibata, Toshiro Fujita
- Organizer
  American Society of Nephrology Kidney Week 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 糖尿病性腎症でエピゲノム異常をきたす核内受容体PXRは腎糖新生を調整する2017
- Author(s)
  渡邉篤史丸茂丈史河原崎和歌子西本光宏鮎澤信宏広浜大五郎上田浩平熊谷裕生藤田敏郎
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 食塩感受性高血圧の内分泌学的および腎生理学的検討2017
- Author(s)
  西本光宏
- Organizer
  第90回日本内分泌学会学術総会　シンポジウム6　食塩感受性の分子機序
- Place of Presentation
  京都府京都市
- Year and Date
  2017-04-20
- Invited
- Data Source
  KAKENHI-PROJECT-26860547
[Presentation] 加齢と食塩感受性高血圧～抗加齢因子Klothoの発現低下はRhoA活性化による血管収縮を惹起する～2017
- Author(s)
  河原崎和歌子、水野理介、西本光宏、鮎澤信宏、広浜大五郎、上田浩平、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第40回日本高血圧学会総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Systemic effect of renal 11beta-HSD2 deficiency on blood pressure regulation2017
- Author(s)
  Kohei Ueda, Mitsuhiro Nishimoto, Daigoro Hirohama, Nobuhiro Ayuzawa, Wakako Kawarazaki, Atsushi Watanabe, Tatsuo Shimosawa, Johannes Loffing, Ming-Zhi Zhang, Takeshi Marumo, Toshiro Fujita
- Organizer
  AHA Council on Hypertension American Society of Hypertension Joint Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] The mechanism of blood pressure elevation in distal nephron-specific Hsd11b2 knockout mice2016
- Author(s)
  Kohei Ueda, Mitsuhiro Nishimoto, Wakako Kawarazaki, Nobuhiro Ayuzawa, Daigoro Hirohama, Atsushi Watanabe, Takeshi Marumo, Toshiro Fujita
- Organizer
  The 41st International Aldosterone Conference Aldosterone and Mineralocorticoids
- Place of Presentation
  Boston, USA
- Year and Date
  2016-03-30
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] PendrinとNCC発現調節におけるアンジオテンシンIIとアルドステロンの異なる役割2016
- Author(s)
  広浜大五郎, 柴田茂, 上田浩平, 鮎澤信宏, 西本光宏, 河原崎和歌子, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 血管内皮機能調節におけるカルシウムセンサーSTIM1の役割の解析2016
- Author(s)
  西本光宏、水野理介、丸茂丈史、河原崎和歌子、鮎澤信宏、広浜大五郎、上田浩平、一色政志、藤田敏郎
- Organizer
  第11回Vascular Biology Innovationに関する研究助成　研究発表会
- Place of Presentation
  東京
- Year and Date
  2016-08-20
- Data Source
  KAKENHI-PROJECT-26860547
[Presentation] 抗加齢因子Klotho発現低下に伴う食塩感受性高血圧発症機序の解明2016
- Author(s)
  河原崎和歌子, 丸茂丈史, 西本光宏, 鮎澤信宏, 広浜大五郎, 上田浩平, 渡邉篤史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] 間在細胞EGFP標識マウスを用いた間在細胞分取・解析法の確立2016
- Author(s)
  鮎澤信宏, 上田浩平, 広浜大五郎, 西本光宏, 河原崎和歌子, 渡邉篤史, 丸茂丈史, 藤田敏郎
- Organizer
  第59回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] カルシウムセンサーSTIM1は内皮機能調節を介して血圧を制御する2016
- Author(s)
  西本光宏、水野理介、丸茂丈史、河原崎和歌子、鮎澤信宏、広浜大五郎、上田浩平、一色政志、藤田敏郎
- Organizer
  第20回日本心血管内分泌代謝学会学術総会 YIA候補講演
- Place of Presentation
  東京
- Year and Date
  2016-12-16
- Data Source
  KAKENHI-PROJECT-26860547
[Presentation] 遠位ネフロン特異的Rac1欠損マウスを用いたRac1-ミネラロコルチコイド受容体（MR）経路の解析2015
- Author(s)
  鮎澤信宏、上田浩平、広浜大五郎、西本光宏、河原崎和歌子、渡邉篤史、丸茂丈史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Eplerenoneは塩分過剰摂取によるRA系阻害抵抗性腎障害を抑制する−EVALUATE試験サブ解析−2015
- Author(s)
  西本光宏、大津洋、丸茂丈史、河原崎和歌子、鮎澤信宏、上田浩平、広浜大五郎、渡邉篤史、藤田敏郎
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-06-05
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] Epigenetic abnormalities underlie increased expression of nuclear receptor PXR in diabetic kidney disease2015
- Author(s)
  Atsushi Watanabe, Takeshi Marumo, Wakako Kawarazaki, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Daigoro Hirohama, Kohei Ueda, Hiroo Kumagai, Toshiro Fujita
- Organizer
  Kidney Week 2015 ASN Annual Meeting
- Place of Presentation
  San Diego, USA
- Year and Date
  2015-11-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05788
[Presentation] STIM1は血管内皮細胞においてNO産生を介して血圧調節に関与する2015
- Author(s)
  西本光宏、水野理介、丸茂丈史、河原崎和歌子、鮎澤信宏、広浜大五郎、上田浩平、一色政志、藤田敏郎
- Organizer
  第10回高血圧と冠動脈疾患研究会
- Place of Presentation
  大手町サンケイプラザ
- Year and Date
  2015-12-19
- Data Source
  KAKENHI-PROJECT-26860547
[Presentation] STIM1 regulates blood pressure via NO production in vascular endothelial cells2014
- Author(s)
  Mitsuhiro Nishimoto, Risuke Mizuno, Masashi Isshiki, Toshiro Fujita
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  みやこメッセ（京都市左京区）
- Year and Date
  2014-04-14
- Data Source
  KAKENHI-PROJECT-26860547

1. Marumo Takeshi (70265817)

# of Collaborated Projects: 4 results

# of Collaborated Products: 41 results
2. FUJITA Toshiro (10114125)

# of Collaborated Projects: 2 results

# of Collaborated Products: 36 results
3. 広浜大五郎 (20749353)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
4. 河原崎和歌子 (50424594)

# of Collaborated Projects: 2 results

# of Collaborated Products: 31 results
5. 鮎澤信宏 (50459517)

# of Collaborated Projects: 2 results

# of Collaborated Products: 32 results
6. 柴田茂 (60508068)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
7. 大庭成喜 (80361492)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
8. 下澤達雄 (90231365)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
9. 上田浩平 (80735697)

# of Collaborated Projects: 1 results

# of Collaborated Products: 25 results
10. 森典子 (80431857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. ARAI Eri

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 永江玄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
13. 長瀬美樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishimoto Mitsuhiro 西本 光宏

Research Projects

Research Products

Co-Researchers

Development of the urine test for the diagnosis of the activity of chronic kidney disease by the epigenetic methodPrincipal Investigator

Principal Investigator

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Research Institution

Exploration of epigenetic mechanisms underlying development of life style-related disease

Principal Investigator

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Review Section

Research Institution

Exploratory research about the mechanism of prenatal programmed hypertensionPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

The role of glucocorticoid in renal tubules modulating diurnal change in blood pressurePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

生活習慣病の高血圧／臓器障害における糖質・鉱質コルチコイドの役割と新規治療探索

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel strategy for life style disease through exploration of the roles of mineral- and gluco-corticoids in hypertension and organ dysfunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of STIM1 in vascular endothelial cells in the progression of atherosclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Aberrant proximal tubule DNA methylation underlies phenotypic changes related to kidney dysfunction in patients with diabetes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of Rac1-mineralocorticoid receptor pathway contributes to renal injury in salt-loaded db/db mice.2021

Author(s)

Journal Title

Data Source

[Journal Article] PGI2 Analog Attenuates Salt-Induced Renal Injury through the Inhibition of Inflammation and Rac1-MR Activation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 医学と医療の最前線 胎児期から成人にいたる食塩感受性高血圧2020

Author(s)

Journal Title

Data Source

[Journal Article] 特集 いま知っておきたい! 内科最新トピックス 巻頭トピックス 選択的ミネラルコルチコイド受容体拮抗薬の使い方2020

Author(s)

Journal Title

Data Source

[Journal Article] Methylation pattern of urinary DNA as a marker of kidney function decline in diabetes.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Salt causes aging-associated hypertension via vascular Wnt5a under Klotho deficiency2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Mineralocorticoid Receptor-Mediated Mechanisms of Pendrin Activation in Distal Nephrons.2020

Author(s)

Nishimoto Mitsuhiro 西本光宏

[Journal Article] 医学と医療の最前線胎児期から成人にいたる食塩感受性高血圧2020

[Journal Article] 特集いま知っておきたい!　内科最新トピックス巻頭トピックス選択的ミネラルコルチコイド受容体拮抗薬の使い方2020