OHYAMA Kaname 大山要

Researcher Number	50437860
Other IDs
External Links
Affiliation (Current)	2025: 長崎大学, 病院(医学系), 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 長崎大学, 病院(医学系), 教授 2014 – 2023: 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 2022: 長崎大学, 医歯薬学総合研究科(薬学系), 教授 2021: 長崎大学, 医歯薬学総合研究科, 教授 2014: 長崎大学, 医歯薬学総合研究科(医学系), 准教授 … More 2013: 長崎大学, 大学院医歯薬学総合研究科, 准教授 2012 – 2013: 長崎大学, 医歯(薬)学総合研究科, 准教授 2012: 長崎大学, 大学院・医歯薬学総合研究科, 准教授 2011: 長崎大学, 医歯(薬)学総合研究科, 助教 2010 – 2011: 長崎大学, 大学院・医歯薬学総合研究科, 助教 Less
Review Section/Research Field	Principal Investigator Medium-sized Section 58:Society medicine, nursing, and related fields / Collagenous pathology/Allergology / Medical pharmacy Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 47060:Clinical pharmacy-related / Basic Section 56030:Urology-related / 膠原病・アレルギー・感染症内科学 / Basic Section 56020:Orthopedics-related / Basic Section 57080:Social dentistry-related / Basic Section 55050:Anesthesiology-related … More / Basic Section 49060:Virology-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Tumor therapeutics / Medical pharmacy / Urology / Laboratory medicine Less
Keywords	Principal Investigator 免疫複合体 / バイオマーカー / 人工知能 / 関節リウマチ / 臨床化学 / 精神疾患 / 視える化 / ゲーム障害 / MRI / 早期スクリーニング … More / 脳画像 / ゲーム症 / 先制医療 / 健診コホート / リウマチ学 / 抗体医薬品 / 血清 / 質量分析 / 抗体医薬 / アルブミン / プロテオーム解析 / 電気クロマトグラフィー / 蛍光プローブ / HSA … More Except Principal Investigator 関節リウマチ / コホート研究 / 人工知能 / バイオマーカー / 免疫複合体 / TGF-b / 全身性強皮症 / 関節エコー / 関節超音波 / 免疫チェックポイント阻害剤 / 効果予測 / イムノコンプレキソーム解析法 / 膀胱癌 / MRI / イムノコンプレキソーム / 骨系統疾患 / ヒストンメチル化 / Mhyre症候群 / 液相分離 / IDR / ヒストンメチル化酵素 / Smad3 / TGFシグナル / Myhre syndrome / エピトープ / 腫瘍関連抗原 / リスクマーカー / 歯周病 / Rabタンパク質 / 炎症応答 / ドラッグデリバリーシステム / 核酸医薬 / 自己抗体 / 筋紡錘 / 筋傷害モデル / 悪性腸腰筋症候群 / MCP-1 / M1・M2 / ケモカイン / M1・M2単球 / 単球 / 宿主因子 / ウイルスマトリックスタンパク質 / 高病原性ウイルス / 咀嚼機能検査 / プロテオーム解析 / メタボローム解析 / オーラルフレイル / 唾液 / 口腔機能低下症 / オーラル・フレイル / がん免疫療法 / 抗原エピトープ / 発症予測 / Large tumor suppressor 2 / SSEA-4 / large tumor suppressor 2 / 去勢抵抗性前立腺癌 / 前立腺癌 / 治療反応スコア / 関節画像 / 精密医療 / ACPA / イムノフェノタイピング / 破骨細胞 / コラーゲン誘発関節炎 / 骨破壊 / 滑膜炎 / 関節画像評価 / 遠隔診療 / Internet of Things（IoT) / 遠隔医療 / 人工知能（AI） / 抗リウマチ薬 / 免疫学的プロファイリング / 免疫学的プロファイル / 泌尿器 / 高齢 / 膀胱 / 慢性炎症 / 間質性膀胱炎 / 関節傷害 / 関節裂隙 / 高解像度CT / HR-pQCT / 骨関節破壊 / 高解像度CT（HRpQCT） / 関節破壊 / 二ボルマブ / 免疫療法 / 症例集積開始 / 効果予測因子の検出 / 免疫複合体解析 / 症例集積 / 倫理委員会承認 / プロトコール作成 / イムノコンプレキソーム法 / 効果予測因子 / ニボルマブ / 抗PD-1抗体 / 肺がん / 肝線維化抑制効果 / T-LEX 法 / トキシコゲノミクス / スクリーニング / 創薬 / 肝臓線維化抑制効果 / ヒト肝細胞キメラマウス / ドラッグリポジショニング / 有害事象予測 / BCG膀胱内注入療法 / 尿 / 動物モデル / 尿路再発 / 膀胱内注入療法 / 尿中ペプチド / Thrombospondins / 4N1K-peptide / 尿路癌 / セルロプラスミン / 重症化予測 / 治療 / MRI骨炎 / 骨炎 / X線進行予測 / 診断 / MRI骨髄浮腫 / サイトカイン・増殖因子 / FLS / PF-4 / LC-MS/MS / seronegative RA / サイトカイン/増殖因子 / パワードプラ / 疾患活動性 / サイトカイン／増殖因子 / VEGF / TGF-β1 / TSP-1 / 滑膜細胞 / RA / リウマチ学 / ビタミンK / マイクロプレートリーダー / 化学発光反応 / キノン付加体 / HPLC / 酸化還元サイクル / 活性酸素 / キノン / 高速液体クロマトグラフィー / ハイスループット分析 / 化学発光 / 生体キノン / 臨床化学 Less

プロテオミクス x 機能的MRI x AIで導く「ゲーム依存の視える化」と社会実装研究Principal Investigator
- Principal Investigator
  
  大山要
- Project Period (FY)
  2025 – 2029
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
全身性強皮症における新規病態関連因子の同定：免疫複合体に着目した検討
- Principal Investigator
  
  岩本直樹
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagasaki University
コホートを用いた歯周病と全身炎症を繋ぐ分子基盤の解明と病態制御への応用
- Principal Investigator
  
  門脇知子
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57080:Social dentistry-related
- Research Institution
  Nagasaki University
Challenge to "visualize mental illness" to realize a symbiotic society with illnessPrincipal Investigator
- Principal Investigator
  
  大山要
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
Basic development of highly directed cancer immunotherapy targeting bladder cancer-specific antigens and epitopes
- Principal Investigator
  
  中嶋幹郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagasaki University
骨系統疾患治療のゲームチェンジャー:ヒストン修飾を標的にした治療法の開発
- Principal Investigator
  
  木下晃
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  Nagasaki University
組織標的化リガンドによる核酸医薬のオンデマンド送達の実現
- Principal Investigator
  
  山本剛史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagasaki University
関節炎が起こる前段階で関節リウマチの発症を人工知能で予測する多角的研究
- Principal Investigator
  
  玉井慎美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagasaki University
Can we prevent the social penetration of gaming disorder? Basic research for integrated scientific evaluation and early countermeasures against gaming disorderPrincipal Investigator
- Principal Investigator
  
  大山要
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
Identification of the trafficking pathway of the highly pathogenic viral proteins
- Principal Investigator
  
  Urata Shuzo
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Nagasaki University
Identification of novel biomarkers and therapeutic targets for systemic scleroderma approached by analysis of monocyte function.
- Principal Investigator
  
  Iwamoto Naoki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagasaki University
悪性腸腰筋症候群の病態に筋紡錘が与える影響の解明と疼痛コントロール方法の検討
- Principal Investigator
  
  石井浩二
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Nagasaki University
Development of cancer immunotherapy pinpointing tumor cells of lung adenocarcinoma
- Principal Investigator
  
  Nakashima Mikiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagasaki University
Construction of preemptive medicine for rheumatoid arthritis based on proteomics and artificial intelligence of a medical examination cohortPrincipal Investigator
- Principal Investigator
  
  大山要
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
Development of examination methods for oral hypofunction: A cohort study
- Principal Investigator
  
  SAWASE Takashi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Nagasaki University
Construction of next-generation treatment algorithm for rheumatoid arthritis aiming at "true remission" applying AI
- Principal Investigator
  
  Kawashiri Shin-ya
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagasaki University
Pathology evaluation research of rheumatoid arthritis leading to the realization of precision medicine
- Principal Investigator
  
  Kawakami Atsushi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagasaki University
A study of specific pathological features of castration-resistant prostate cancer using immune complexome analysis
- Principal Investigator
  
  Sakai Hideki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Nagasaki University
Elucidation of the mechanism of joint destruction in rheumatoid arthritis: approach using high-resolution CT
- Principal Investigator
  
  Tamai Mami
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Nagasaki University
Elucidation of the pathophysiology of interstitial cystitis by immunological profiling and development of novel diagnostic tools and treatment methods
- Principal Investigator
  
  MATSUO Tomohiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Nagasaki University
Development of drug discovery method to increase the success rate of drug repositioning drug discovery
- Principal Investigator
  
  NAKASHIMA Mikiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University
Precise identification of epitope of immune complex antigen and development of inhibitory agent on their formation specific for rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  OHYAMA Kaname
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Nagasaki University
A novel predicitve model of urinary tract recurrence in urothelial cancer by comprehensive analyses of urine immunocomplex
- Principal Investigator
  
  MIYATA Yasuyoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Urology
- Research Institution
  Nagasaki University
Discovery of effect predictor of anti-PD-1 antibody in lung cancer
- Principal Investigator
  
  IKEDA Takaya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Nagasaki University
Immune complexome analysis of tissue-deposited immune complexes for application to tissue in autoimmune diseasesPrincipal Investigator
- Principal Investigator
  
  OHYAMA Kaname
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  Nagasaki University
The examination of utility of MRI bone edema in early rheumatoid arthritis
- Principal Investigator
  
  TAMAI Mami
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Nagasaki University
Development of rapid and simple method for determination of monoclonal antibody drug and its application to clinical samplesPrincipal Investigator
- Principal Investigator
  
  OHYAMA KANAME
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University
Investigation of autoantigens in patients with rheumatoid arthritis through protemic analysis: exploration from diagnosis, pathogenesis to therapy
- Principal Investigator
  
  KAWAKAMI Atsushi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Nagasaki University
Development of selective chemiluminescence assay for biologicalquinones and its application to clinical investigation
- Principal Investigator
  
  KURODA Notaka
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Nagasaki University
Development of screening method for albumin biomarker for personalized medicinePrincipal Investigator
- Principal Investigator
  
  OHYAMA Kaname
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Nagasaki University

[Book] Immunoproteomics: Methods and Protocols, Second Edition (Methods in Molecular Biology)2019
- Author(s)
  N. Aibara, K. Ohyama
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-16H05344
[Book] Immune complexome analysis. Advances in Clinical Chemistry volume 60, Ed. by G. Makowski, Elsevier, Chapter 42013
- Author(s)
  K. Ohyama, N. Kuroda
- Data Source
  KAKENHI-PROJECT-24790158
[Book] Advances in Clinical Chemistry volume 602013
- Author(s)
  Kaname Ohyama, Naotaka Kuroda
- Total Pages
  13
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-24790158
[Book] Quantification of vitamin K in foods. In Fortified Foods with Vitamins : Analytical Concepts to Assure Better and Safer Products2011
- Author(s)
  S.Ahmed, N.Kishikawa, K.Ohyama, N.Kuroda
- Total Pages
  20
- Publisher
  Wiley & Sons, New York
- Data Source
  KAKENHI-PROJECT-22390116
[Book] Quantification of vitamin K in foods. In Fortified Foods with Vitamins: Analytical Concepts to Assure Better and Safer Products2011
- Author(s)
  Ahmed S, Kishikawa N, Ohyama K, Kuroda N
- Publisher
  Rychlik Meds; Wiley & Sons, New York
- Data Source
  KAKENHI-PROJECT-22390116
[Book] キノンの選択的化学発光検出法とその臨床化学的応用2010
- Author(s)
  黒田直敬,岸川直哉,大山要
- Publisher
  臨床化学
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Immune complexome analysis of a rich variety of serum immune complexes identifies disease-characteristic immune complex antigens in systemic sclerosis2023
- Author(s)
  Kutsuna Yuki Jimbayashi、Iwamoto Naoki、Ichinose Kunihiro、Aibara Nozomi、Nakashima Katsumi、Nakamura Hideki、Koike Yuta、Murota Hiroyuki、Ueki Yukitaka、Miyamoto Hirotaka、Hashizume Junya、Kodama Yukinobu、Nakashima Mikiro、Kawakami Atsushi、Ohyama Kaname
- Journal Title
  
  Journal of Autoimmunity
  
  Volume: 134 Pages: 102954-102954
- DOI
  10.1016/j.jaut.2022.102954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08439, KAKENHI-PROJECT-20K08654
[Journal Article] Determination Method for Pyrroloquinoline Quinone in Food Products by HPLC-UV Detection Using a Redox-Based Colorimetric Reaction2022
- Author(s)
  Fukuda Mizuho、Kishikawa Naoya、Samemoto Taketo、Ohta Kaoru、Ohyama Kaname、El-Maghrabey Mahmoud Hamed、Ikemoto Kazuto、Kuroda Naotaka
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 70 Issue: 1 Pages: 32-36
- DOI
  10.1248/cpb.c21-00638
- NAID
  130008138712
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2022-01-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04853, KAKENHI-PROJECT-20K20617
[Journal Article] Immune complexome analysis of serum samples from non-small-cell lung cancer patients identifies predictive biomarkers for nivolumab therapy2022
- Author(s)
  Aizawa Rika、Nakamura Yoichi、Ikeda Takaya、Aibara Nozomi、Kutsuna Yuki J.、Kurosaki Tomoaki、Aki Keisei、Junya Hashizume、Nakagawa Hiroo、Sato Kayoko、Kodama Yukinobu、Nakashima Mihoko N.、Nakashima Mikiro、Mukae Hiroshi、Ohyama Kaname
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 532 Pages: 84-88
- DOI
  10.1016/j.cca.2022.05.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07177
[Journal Article] Evaluation of four commercial severe acute respiratory coronavirus 2 antibody tests2021
- Author(s)
  Ashizawa Nobuyuki、Takazono Takahiro、Ohyama Kaname、et al
- Journal Title
  
  Journal of Infection and Chemotherapy
  
  Volume: 27 Issue: 7 Pages: 1033-1038
- DOI
  10.1016/j.jiac.2021.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04853, KAKENHI-PROJECT-21K08506, KAKENHI-PROJECT-20K20617
[Journal Article] <i>Itpr1</i> regulates the formation of anterior eye segment tissues derived from neural crest cells2021
- Author(s)
  Kinoshita Akira、Ohyama Kaname、Tanimura Susumu、Matsuda Katsuya、Kishino Tatsuya、Negishi Yutaka、Asahina Naoko、Shiraishi Hideaki、Hosoki Kana、Tomiwa Kiyotaka、Ishihara Naoko、Mishima Hiroyuki、Mori Ryoichi、Nakashima Masahiro、Saitoh Shinji、Yoshiura Koh-ichiro
- Journal Title
  
  Development
  
  Volume: 148 Issue: 16 Pages: 188755-188755
- DOI
  10.1242/dev.188755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K21583, KAKENHI-PROJECT-21H04853, KAKENHI-PROJECT-20H03591, KAKENHI-PROJECT-20H03646, KAKENHI-PROJECT-19K09993, KAKENHI-PROJECT-20K08886, KAKENHI-PROJECT-21K06069, KAKENHI-PROJECT-21K07800, KAKENHI-PROJECT-20K20617
[Journal Article] Detection of Novel Urine Markers Using Immune Complexome Analysis in Bladder Cancer Patients: A Preliminary Study2021
- Author(s)
  AIBARA NOZOMI、MIYATA YASUYOSHI、ARAKI KYOHEI、SAGARA YUJI、MITSUNARI KENSUKE、MATSUO TOMOHIRO、OHBA KOJIRO、MOCHIZUKI YASUSHI、SAKAI HIDEKI、OHYAMA KANAME
- Journal Title
  
  In Vivo
  
  Volume: 35 Issue: 4 Pages: 2073-2080
- DOI
  10.21873/invivo.12476
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04853, KAKENHI-PROJECT-20K09528, KAKENHI-PROJECT-20K20617
[Journal Article] Ceruloplasmin Levels in Cancer Tissues and Urine Are Significant Biomarkers of Pathological Features and Outcome in Bladder Cancer2021
- Author(s)
  MUKAE YUTA、ITO HIDENORI、MIYATA YASUYOSHI、ARAKI KYOHEI、MATSUDA TSUYOSHI、AIBARA NOZOMI、NAKAMURA YUICHIRO、MATSUO TOMOHIRO、SAKAI HIDEKI、OHYAMA KANAME
- Journal Title
  
  Anticancer Research
  
  Volume: 41 Issue: 8 Pages: 3815-3823
- DOI
  10.21873/anticanres.15174
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04853, KAKENHI-PROJECT-20K20617
[Journal Article] Optimization of pH Elution Conditions in Immune Complexome Analysis for Comprehensive Identification of Immune Complex Antigens2020
- Author(s)
  AIBARA Nozomi、AIZAWA Rika、NAKASHIMA Mikiro、OHYAMA Kaname
- Journal Title
  
  Analytical Sciences
  
  Volume: 36 Pages: 1423-1426
- NAID
  130007937700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07177
[Journal Article] Selective, sensitive and comprehensive detection of immune complex antigens by immune complexome analysis with papain-digestion and elution2019
- Author(s)
  Aibara N, Kamohara C, Chauhan AK, Kishikawa N, Miyata Y, Nakashima M, Kuroda N, Ohyama K
- Journal Title
  
  Journal of Immunological Methods
  
  Volume: 461 Pages: 85-90
- DOI
  10.1016/j.jim.2018.06.021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05344
[Journal Article] Immune complexome analysis of antigens in circulating immune complexes from patients with acute cellular rejection after living donor liver transplantation.2018
- Author(s)
  Aibara N, Ohyama K, Hidaka M, Kishikawa N, Miyata Y, Takatsuki M, Eguchi S, Kuroda N.
- Journal Title
  
  Transplant Immunology
  
  Volume: 3274 Pages: 30143-0
- DOI
  10.1016/j.trim.2018.02.011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15690, KAKENHI-PROJECT-16H05344, KAKENHI-PROJECT-15K15373
[Journal Article] Proteomic approach to profiling immune complex antigens in cerebrospinal fluid samples from patients with central nervous system autoimmune diseases.2018
- Author(s)
  Aibara N, Ichinose K, Baba M, Nakajima H, Satoh K, Atarashi R, Kishikawa N, Nishida N, Kawakami A, Kuroda N, Ohyama K
- Journal Title
  
  Clin Chim Acta
  
  Volume: 484 Pages: 26-31
- DOI
  10.1016/j.cca.2018.05.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09759, KAKENHI-PROJECT-17K09977, KAKENHI-PROJECT-16H05344
[Journal Article] Novel anti-suprabasin antibodies may contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus.2018
- Author(s)
  Ichinose K, Ohyama K, Furukawa K, Higuchi O, Mukaino A, Satoh K, Nakane S, Shimizu T, Umeda M, Fukui S, Nishino A, Nakajima H, Koga T, Kawashiri SY, Iwamoto N, Tamai M, Nakamura H, Origuchi T, Yoshida M, Kuroda N, Kawakami A.
- Journal Title
  
  Clin Immunol.
  
  Volume: 印刷中 Pages: 123-130
- DOI
  10.1016/j.clim.2017.11.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09977, KAKENHI-PROJECT-16H05344, KAKENHI-PROJECT-15K15373, KAKENHI-PROJECT-16K19605
[Journal Article] Immune complexome analysis reveals specific and frequent presence of immune complex antigens in lung cancer patients: A pilot study.2017
- Author(s)
  K. Ohyama, H. Yoshimi, N. Aibara, Y. Nakamura, Y. Miyata, H. Sakai, F. Fujita, Y. Imaizumi, A.K. Chauhan, N. Kishikawa, N. Kuroda
- Journal Title
  
  International Journal of Cancer
  
  Volume: 140 Issue: 2 Pages: 370-380
- DOI
  10.1002/ijc.30455
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05344, KAKENHI-PROJECT-15K07890, KAKENHI-PROJECT-17H04112
[Journal Article] 後発医薬品の信頼性向上の取組として開発された T-LEX 法2017
- Author(s)
  中嶋幹郎、大山　要
- Journal Title
  
  ファルマシア
  
  Volume: 53 Pages: 787-789
- Data Source
  KAKENHI-PROJECT-17K08448
[Journal Article] Proteomic profile of circulating immune complexes in chronic Chagas disease.2016
- Author(s)
  Ohyama K, Huy NT, Yoshimi H, Kishikawa N, Nishizawa JE, Roca Y, Revollo Guzman RJ, Velarde FU, Kuroda N, Hirayama K
- Journal Title
  
  Parasite Immunology
  
  Volume: 38 Issue: 10 Pages: 609-617
- DOI
  10.1111/pim.12341
- NAID
  120006987634
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670283, KAKENHI-PROJECT-15K15373
[Journal Article] Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-beta1 toward Fibroblast-like Synovial Cells2015
- Author(s)
  Suzuki T, Iwamoto N, Yamasaki S, Nishino A, Nakashima Y, Horai Y, Kawashiri S, Y Ichinose K, Arima K, Tamai M, Nakamura H, Origuchi T, Miyamoto C, Osaki M, Ohyama K, Kuroda N, Kawakami A.
- Journal Title
  
  Journal of Rheumatology
  
  Volume: 42 Issue: 6 Pages: 943-947
- DOI
  10.3899/jrheum.141292
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09531, KAKENHI-PROJECT-26461463, KAKENHI-PROJECT-15K15373
[Journal Article] Optimization of separation and digestion conditions in immune complexome analysis2013
- Author(s)
  M. Baba, K. Ohyama, N. Kishikawa, N. Kuroda
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 443 Pages: 181-186
- NAID
  120006986089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790158
[Journal Article] Proteomic approaches to profile the humoral immune response and identify disease-associated antigens2012
- Author(s)
  Ohyama K, Kuroda N
- Journal Title
  
  Biol Pharm Bull
  
  Volume: 35 Pages: 1409-12
- NAID
  130001872092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Serum immune complex containing thrombospondin-1: a novel biomarker for early rheumatoid arthritis2012
- Author(s)
  Ohyama K, Kawakami A, Tamai M, Baba M, Kishikawa N, Kuroda N
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71 Pages: 1916-7
- NAID
  120006985489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Serum immune complex containing thrombospondin-1 : a novel biomarker for early rheumatoid arthritis2012
- Author(s)
  K. Ohyama, A. Kawakami, M. Tamai, M. Baba, N. Kishikawa, N. Kuroda
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 71 Pages: 1916-1917
- NAID
  120006985489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790158
[Journal Article] Determination of glyoxylic acid in urine by liquid chromatography with fluorescence detection, using a novel derivatization procedure based on the Petasis reaction.2012
- Author(s)
  Chihara K, Kishikawa N, Ohyama K, Nakashima K, Kuroda N
- Journal Title
  
  Anal Bioanal Chem
  
  Volume: 403 Pages: 2765-70
- NAID
  120006985639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Determination of glyoxylic acid in urine by liquid chromatography with fluorescence detection, using a novel derivatization procedure based on the Petasis reaction2012
- Author(s)
  Chihara K, Kishikawa N, Ohyama K, Nakashima K, Kuroda N
- Journal Title
  
  Anal Bioanal Chem
  
  Volume: 403 Issue: 9 Pages: 2765-2770
- DOI
  10.1007/s00216-012-6036-1
- NAID
  120006985639
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Microplate analytical method for quinones by pulse photo-irradiation and chemiluminescence detection2012
- Author(s)
  Elgawish MS, Shimomai C, Kishikawa N, Ohyama K, Nakashima K, Kuroda N
- Journal Title
  
  Analyst
  
  Volume: 137 Pages: 4802-8
- NAID
  120006985759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers2012
- Author(s)
  Ohyama K, Shiokawa A, Ito K, Masuyama R, Ichibangase T, Kishikawa N, Imai K, Kuroda N
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420 Issue: 1 Pages: 210-215
- DOI
  10.1016/j.bbrc.2012.03.009
- NAID
  120006985424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Serum immune complex containing thrombospondin-1: a novel biomarker for early rheumatoid arthritis2012
- Author(s)
  Ohyama K, Kawakami A, Tamai M, Baba M, Kishikawa N, Kuroda N
- Journal Title
  
  Ann Rheum Dis
  
  Volume: 71(11) Pages: 1916-7
- NAID
  120006985489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591439
[Journal Article] Toxicoproteomic analysis of a mouse model of nonsteroidal anti-inflammatory drug-induced gastric ulcers.2012
- Author(s)
  Ohyama K, Shiokawa A, Ito K, Masuyama R, Ichibangase T, Kishikawa N, Imai K, Kuroda N
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 420 Pages: 210-5
- NAID
  120006985424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Serum immune complex containing thrombospondin-1: a novel biomarker for early rheumatoid arthritis.2012
- Author(s)
  Ohyama K, Kawakami A, Tamai M, Baba M, Kishikawa N, Kuroda N
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 71 Issue: 11 Pages: 1916-1917
- DOI
  10.1136/annrheumdis-2012-201305
- NAID
  120006985489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591439
[Journal Article] Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients2011
- Author(s)
  S.Ahmed, K.Ohyama, N.Kuroda, et al.
- Journal Title
  
  Talanta
  
  Volume: (accepted)
- NAID
  120006985258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Monolithic poly(butyl methacrylate-ethylene dimethacrylate-methacrylic acid) column for capillary electrochromatography.2011
- Author(s)
  Ohyama K, Horiguchi D, Kishikawa N, Kuroda N
- Journal Title
  
  J Sep Sci
  
  Volume: 34 (16-17) Pages: 2279-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Immune complexome analysis of serum and its application in screening for immune complex antigens in rheumatoid arthritis2011
- Author(s)
  K. Ohyama, Y. Ueki, A. Kawakami, N. Kishikawa, M. Tamai, M. Osaki, S. Kamihira, K. Nakashima, N. Kuroda*
- Journal Title
  
  Clinical Chemistry
  
  Volume: 57 Pages: 905-909
- Data Source
  KAKENHI-PROJECT-22790160
[Journal Article] Immune complexome analysis of serum and its application in screening for immune complex antigens in rheumatoid arthritis2011
- Author(s)
  Ohyama K, Ueki Y, Kawakami A, Kishikawa N, Tamai M, Osaki M, Kamihira S, Nakashima K, Kuroda N
- Journal Title
  
  Clin Chem
  
  Volume: 57(6) Pages: 905-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591439
[Journal Article] 4-Carbomethoxybenzaldehyde as a highly sensitive pre-column fluorescence derivatization reagent for 9,10-phenanthrenequinone2011
- Author(s)
  Kishikawa N, Nakao M, Elgawish MS, Ohyama K, Nakashima K, Kuroda N
- Journal Title
  
  Talanta
  
  Volume: 85 (1) Pages: 809-12
- NAID
  120006985064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Selective determination of ubiquinone in human plasma by HPLC with chemiluminescence reaction based on the redox cycle of quinone2011
- Author(s)
  N.Kishikawa, K.Ohyama, N.Kuroda, et al.
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 400 Pages: 381-385
- NAID
  120006984800
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Monolithic poly(butyl methacrylate-ethylene dimethacrylate-methacrylicacid) column for capillary electrochromatography2011
- Author(s)
  Kaname Ohyama, Daisuke Horiguchi, 他
- Journal Title
  
  Journal of Separation Science
  
  Volume: 34 Issue: 16-17 Pages: 2279-2283
- DOI
  10.1002/jssc.201100198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790160
[Journal Article] 4-Carbomethoxybenzaldehyde as a highly sensitive pre-column fluorescence derivatization reagent for 9,10-phenanthrenequinone2011
- Author(s)
  N.Kishikawa, M.Nakao, M.S.Elgawish, K.Ohyama, K.Nakashima, N.Kuroda
- Journal Title
  
  Talamta
  
  Volume: 85 Issue: 1 Pages: 809-812
- DOI
  10.1016/j.talanta.2011.03.085
- NAID
  120006985064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Immune complexome analysis of serum and its application in screening for immune complex antigens in rheumatoid arthritis.2011
- Author(s)
  Ohyama K, Ueki Y, Kawakami A, Kishikawa N, Tamai M, Osaki M, Kamihira S, Nakashima K, Kuroda N.
- Journal Title
  
  Clin Chem
  
  Volume: 57 (6) Issue: 6 Pages: 905-909
- DOI
  10.1373/clinchem.2010.157776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591439, KAKENHI-PROJECT-23659301, KAKENHI-PROJECT-24790158
[Journal Article] Labeling of alprenolol with fluorescent aryl iodide as a reagent based on Mizoroki-Heck coupling reaction2011
- Author(s)
  Kishikawa N, Ohkuma M, Wada M, Ohyama K, Ikeda R, Nakashima K, Kuroda N
- Journal Title
  
  J Chromatogr A
  
  Volume: 1218 (20) Pages: 3002-6
- NAID
  120006985106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Effects of temperature and mobile phase condition on chiral recognition of poly(L-phenylalanine) chiral stationary phase2011
- Author(s)
  Ohyama K, Oyamada K, Kishikawa N, Wada M, Ohba Y, Nakashima K, Kuroda N
- Journal Title
  
  Chromatographia
  
  Volume: 74 (5-6) Pages: 467-70
- NAID
  120006985046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Immune complexome analysis of serum and its application in screening for immune complex antigens in rheumatoid arthritis.2011
- Author(s)
  Ohyama K, Ueki Y, Kawakami A, Kishikawa N, Tamai M, Osaki M, Kamihira S, Nakashima K, Kuroda N
- Journal Title
  
  Clin Chem
  
  Volume: 57 (6) Pages: 905-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Selective determination of ubiquinone in human plasma by HPLC with chemiluminescence reaction based on the redox cycle of quinine2011
- Author(s)
  Kishikawa N, Ohkubo N, Ohyama K, Nakashima K, Kuroda N
- Journal Title
  
  Anal Bioanal Chem
  
  Volume: 400 (2) Pages: 381-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Monolithic poly(butyl methacrylate-ethylene dimethacrylate-methacrylic acid) column for capillary electrochromatography2011
- Author(s)
  K. Ohyama, D. Horiguchi, N. Kishikawa, N. Kuroda
- Journal Title
  
  Journal of Separation Science
  
  Volume: 34 Pages: 2279-2283
- Data Source
  KAKENHI-PROJECT-22790160
[Journal Article] Selective chemiluminescence method for monitoring of vitamin K homologues in rheumatoid arthritis patients2011
- Author(s)
  Ahmed S, Kishikawa N, Ohyama K, Imazato T, Ueki Y, Kuroda N
- Journal Title
  
  Talanta
  
  Volume: 85 (1) Pages: 230-6
- NAID
  120006985258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Automated analysis of the serum antioxidative activities against five different reactive oxygen species by sequential injection system with a chemiluminescence detector2010
- Author(s)
  N.Kishikawa, K.Ohyama, N.Kuroda, et al.
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 411(1-16) Pages: 1111-1115
- NAID
  120006984533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Automated analysis of the serum antioxidative activities against five different reactive oxygen species by sequential injection system with a chemiluminescence detector2010
- Author(s)
  Kishikawa N, Ohyama K, Yao J, Miyamoto A, Imazato T, Ueki Y, Nakashima K, Maehata E, Kuroda N
- Journal Title
  
  Clin Chim Acta
  
  Volume: 41 Pages: 1111-5
- NAID
  120006984533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence labeled chlorpheniramine with Suzuki coupling reaction2010
- Author(s)
  L.A.Adutwum, K.Ohyama, N.Kuroda, et al.
- Journal Title
  
  Analytical and Bioanalytical Chemistry
  
  Volume: 398 Pages: 823-8239
- NAID
  120006984913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Determination of 9,10-phenanthrenequinone in airborne particulates by high-performance liquid chromatography with post-column fluorescence derivatization using 2-aminothiophenol2010
- Author(s)
  Kishikawa N, Nakashima H, Ohyama K, Nakashima K, Kuroda N
- Journal Title
  
  Talanta
  
  Volume: 81 Pages: 1852-5
- NAID
  120006984471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Automated analysis of the serum antioxidative activities against five different reactive oxygen species by sequential injection system with a chemiluminescence detector2010
- Author(s)
  N. Kishikawa, K. Ohyama, J. Yao, A. Miyamoto, T. Imazato, Y. Ueki, K. Nakashima, E. Maehata, N. Kuroda*
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 411 Pages: 1111-1115
- NAID
  120006984533
- Data Source
  KAKENHI-PROJECT-22790160
[Journal Article] Determination of 9,10-phenanthrenequinone in airborne particulates by high-performance liquid chromatography with post-column fluorescence derivatization using 2-aminothiophenol2010
- Author(s)
  N.Kishikawa, K.Ohyama, N.Kuroda, et al.
- Journal Title
  
  Talanta
  
  Volume: 81 Pages: 1852-1855
- NAID
  120006984471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Evaluation of chemiluminescence reagents for selective detection of reactive oxygen species2010
- Author(s)
  S.Yamaguchi, K.Ohyama, N.Kuroda, et al.
- Journal Title
  
  Analytica Chimica Acta
  
  Volume: 665 Pages: 74-78
- NAID
  120006984532
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Yamaguchi S, Kishikawa N, Ohyama K, Ohba Y, Kohno M, Masuda T, Takadate A, Nakashima K, Kuroda N2010
- Author(s)
  Yamaguchi S, Kishikawa N, Ohyama K, Ohba Y, Kohno M, Masuda T, Takadate A, Nakashima K, Kuroda N
- Journal Title
  
  Anal Chim Acta
  
  Volume: 665 Pages: 74-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Study on the timing of degassing for reproducible preparation of polymer-based monolithic columns2010
- Author(s)
  Ohyama K, Sueyoshi T, Kishikawa N, Nakashima K, Kuroda N
- Journal Title
  
  Chromatographia
  
  Volume: 71 Pages: 971-3
- NAID
  120006984569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] A toxicoproteomic study on cardioprotective effects of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity2010
- Author(s)
  K. Ohyama, M. Tomonari, T. Ichibangase, H. To, N. Kishikawa, K. Nakashima, K. Imai, N. Kuroda
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 80 Pages: 540-547
- NAID
  120006984488
- Data Source
  KAKENHI-PROJECT-22790160
[Journal Article] Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence labeled chlorpheniramine with Suzuki coupling reaction.2010
- Author(s)
  Lawrence LA, Kishikawa N, Ohyama K, Harada S, Nakashima K, Kuroda N
- Journal Title
  
  Anal Bioanal Chem
  
  Volume: 398 Pages: 823-9
- NAID
  120006984913
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Adamantyl-functionalized polymer monolith for capillary electrochromatography2010
- Author(s)
  Ohyama K, Fukahori Y, Nakashima K, Sueyoshi T, Kishikawa N, Kuroda N
- Journal Title
  
  J Chromatogr A
  
  Volume: 1217 Pages: 1501-5
- NAID
  120006984656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] キノンの選択的化学発光検出法とその臨床化学的応用2010
- Author(s)
  黒田直敬、岸川直哉、大山要
- Journal Title
  
  臨床化学
  
  Volume: 39 Pages: 15-21
- NAID
  10026446044
- Data Source
  KAKENHI-PROJECT-22390116
[Journal Article] Automated analysis of the serum antioxidative activities against five different reactive oxygen species by sequential injection system with a chemiluminescence detector.2010
- Author(s)
  Naoya Kishikawa, Kaname Ohyama, et al
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 411 Pages: 1111-1115
- NAID
  120006984533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790160
[Journal Article] A toxicoproteomic study on cardioprotective effects of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity.2010
- Author(s)
  Kaname Ohyama, et al
- Journal Title
  
  Biochemical Pharmacology
  
  Volume: 80 Pages: 540-547
- NAID
  120006984488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790160
[Journal Article] A toxicoproteomic study on cardioprotective effect of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity.2010
- Author(s)
  Ohyama K, Tomonari M, Ichibangase T, To H, Kishikawa N, Nakashima K, Imai K, Kuroda N
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 80 Pages: 540-7
- NAID
  120006984488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390116
[Patent] 中枢神経ループス(NPSLE)診断用バイオマーカー2013
- Inventor(s)
  一瀬邦弘、大山要、川上純、黒田直敬他
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-03-18
- Data Source
  KAKENHI-PROJECT-22390116
[Patent] 中枢神経ループス(NPSLE)診断用バイオマーカー2013
- Inventor(s)
  一瀬邦弘,大山要,川上純,黒田直敬,中嶋秀樹,岸川直哉,馬場雅子
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-055543
- Filing Date
  2013-03-18
- Data Source
  KAKENHI-PROJECT-24790158
[Patent] 中枢神経ループス（NPSLE）診断用バイオマーカー2013
- Inventor(s)
  一瀬邦弘、大山要、川上純、黒田直敬、中嶋秀樹、岸川直哉、馬場雅子
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-055543
- Filing Date
  2013-03-18
- Data Source
  KAKENHI-PROJECT-24790158
[Patent] 免疫複合体の網羅的解析方法および新規関節リウマチバイオマーカー2011
- Inventor(s)
  黒田直敬,大山要,岸川直哉
- Industrial Property Rights Holder
  長崎大学
- Industrial Property Number
  2010-231935
- Filing Date
  2011-10-14
- Overseas
- Data Source
  KAKENHI-PROJECT-22390116
[Patent] 免疫複合体の網羅的解析方法および新規関節リウマチバイオマーカー2011
- Inventor(s)
  黒田直敬, 大山要, 岸川直哉
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Number
  2011-215402
- Filing Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22790160
[Patent] 免疫複合体の網羅的解析方法および新規関節リウマチバイオマーカー2011
- Inventor(s)
  黒田直敬,大山要,岸川直哉
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Number
  2011-215402
- Filing Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-22790160
[Patent] 免疫複合体の網羅的解析方法および新規関節リウマチバイオマーカー2010
- Inventor(s)
  黒田直敬, 大山要, 岸川直哉
- Industrial Property Rights Holder
  国立大学法人長崎大学
- Industrial Property Number
  2010-231935
- Filing Date
  2010-10-14
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] Selective, sensitive and comprehensive detection of immune complex antigens for discovering disease-specific antigens2020
- Author(s)
  N. Aibara, M. Nakashima, N. Kuroda, K. Ohyama
- Organizer
  68th ASMS 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07177
[Presentation] 臨床系教員が薬学の強みを意識して考える医師・薬剤師との共同研究2019
- Author(s)
  大山　要
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H05344
[Presentation] イムノコンプレキソーム解析法における免疫複合体抗原選択的な溶出法の検討2018
- Author(s)
  相原希美，蒲原千裕，Anil Chauhan，岸川直哉，中嶋幹郎，黒田直敬，大山　要
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K15373
[Presentation] 強みを生かせばできる！基礎-臨床双方向の研究展開2018
- Author(s)
  大山　要
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-15K15373
[Presentation] 強みを生かせばできる！基礎-臨床双方向の研究展開2018
- Author(s)
  大山　要
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05344
[Presentation] イムノコンプレキソーム解析法における免疫複合体抗原選択的な溶出法の検討2018
- Author(s)
  相原希美，蒲原千裕，Anil Chauhan，岸川直哉，中嶋幹郎，黒田直敬，大山　要
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16H05344
[Presentation] 生体肝移植後、急性拒絶症例における免疫複合体（イムノコンプレックス）の特徴2017
- Author(s)
  日高匡章，大山　要，相原希美，曽山明彦，足立智彦，大野慎一郎，原　貴信，岡田怜美，濱田隆志，金高賢悟，高槻光寿，江口　晋
- Organizer
  第53回日本移植学会
- Data Source
  KAKENHI-PROJECT-15K15373
[Presentation] 抗体医薬品の薬効実態の評価につながる実効薬物濃度測定法の開発2017
- Author(s)
  田中結唯，大山　要，山田靖子，中嶋弥穂子，中嶋幹郎
- Organizer
  第34回日本薬学会九州支部大会
- Data Source
  KAKENHI-PROJECT-15K15373
[Presentation] 肝臓移植患者の血清中免疫複合体の網羅的解析2016
- Author(s)
  相原希美、大山　要、日高匡章、岸川直哉、黒田直敬
- Organizer
  第41回日本医用マススペクトル学会年会
- Place of Presentation
  愛知県産業労働センター（愛知県・名古屋市）
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-16H05344
[Presentation] イムノコンプレキソーム解析における免疫複合体の捕集方法についての検討-Protein G、Protein A固定化磁気ビーズの比較-2013
- Author(s)
  大山要,吉見春香、馬場雅子、岸川直哉、黒田直敬
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] 関節リウマチ滑膜組織におけるThrombospondin-1(TSP-1)の重要性と調節機能の検討．2013
- Author(s)
  鈴木貴久, 山崎聡士, 中島好一, 寳來吉朗, 岡田覚丈, 川尻真也, 岩本直樹，一瀬邦弘, 玉井慎美, 有馬和彦，中村英樹，折口智樹, 尾崎誠，大山要, 黒田直敬, 植木幸孝，江口勝美, 川上純．
- Organizer
  第34回日本炎症・再生医学会
- Place of Presentation
  国立京都国際会館（京都市）
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] イムノコンプレキソーム解析による自己抗原プロファイリングに基づく自己免疫疾患へのアプローチ2013
- Author(s)
  馬場雅子,大山要、一瀬邦弘、玉井慎美、岸川直哉、川上純、黒田直敬
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] イムノコンプレキソーム解析による自己免疫疾患患者の抗原プロファイリング2013
- Author(s)
  大山要,馬場雅子,玉井慎美,一瀬邦弘,岸川直哉,川上純,黒田直敬
- Organizer
  第24回日本臨床化学会九州支部総会
- Place of Presentation
  沖縄
- Year and Date
  2013-12-09
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] イムノコンプレキソーム解析による自己抗原プロファイリングに基づく自己免疫疾患へのアプローチ2013
- Author(s)
  馬場雅子，大山　要、一瀬邦弘、玉井慎美、岸川直哉、川上　純、黒田直敬．
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  東北大学片平キャンパス（仙台市）
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] イムノコンプレキソーム解析による自己抗原プロファイリングに基づく自己免疫疾患へのアプローチ2013
- Author(s)
  馬場雅子,大山要、一瀬邦弘、玉井慎美、岸川直哉、川上純、黒田直敬
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] 関節リウマチ滑膜組織におけるThrombospondin-1(TSP-1)の重要性と調節機能の検討2013
- Author(s)
  鈴木貴久,山崎聡士,中島好一,寳來吉朗,岡田覚丈,川尻真也,岩本直樹,一瀬邦弘,玉井慎美,有馬和彦,中村英樹,折口智樹,尾崎誠,大山要,黒田直敬,植木幸孝,江口勝美,川上純
- Organizer
  第34回日本炎症・再生医学会
- Place of Presentation
  京都市
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] Immune complexome analysis for identifying immune complex antigens2013
- Author(s)
  Baba M, Ohyama K, Tamai M, Kishikawa N, Kawakami A, Kuroda N
- Organizer
  12^<th> HUPO World Congress
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] イムノコンプレキソーム解析における免疫複合体の捕集方法についての検討－Protein G、Protein A固定化磁気ビーズの比較－2013
- Author(s)
  大山　要、吉見春香、馬場雅子、岸川直哉、黒田直敬
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台市、東北大学
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] Immune complexome analysis for identifying immune complex antigens.2013
- Author(s)
  Baba M, Ohyama K, Tamai M, Kishikawa N, Kawakami A, Kuroda N.
- Organizer
  12th HUPO World Congress
- Place of Presentation
  Pacifico Yokohama（Yokohama）
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] イムノコンプレキソーム解析による自己免疫疾患患者の抗原プロファイリング2013
- Author(s)
  大山　要、馬場雅子、玉井慎美　他
- Organizer
  第24回日本臨床化学会九州支部総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] 生体キノンの化学発光マイクロプレートアッセイのための基礎的検討2013
- Author(s)
  黒田直敬、下舞千香子、Elgawish Mohamed Saleh、岸川直哉、大山要
- Organizer
  第24回日本臨床化学会九州支部総会
- Place of Presentation
  那覇
- Year and Date
  2013-02-09
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] イムノコンプレキソーム解析による自己抗原プロフィリングに基づく自己免疫疾患へのアプローチ2013
- Author(s)
  馬場雅子、大山　要、一瀬邦弘、玉井慎美、岸川直哉、川上　純、黒田直敬
- Organizer
  第7回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  仙台市、東北大学
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] 早期関節リウマチ患者のイムノコンプレキソーム解析2012
- Author(s)
  大山要, 馬場雅子, 川上純, 玉井慎美, 岸川直哉, 植木幸孝, 上平憲, 中島憲一郎, 黒田直敬
- Organizer
  第23回日本臨床化学会九州支部総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] シーケンシャルインジェクションに基づくパーキンソン病誘発物質MPP+の全自動化学発光分析法の開発2012
- Author(s)
  樋口翔,岸川直哉,大山要,中島憲一郎,黒田直敬
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] マイクロプレートリーダーを用いるパルス紫外線照射によるキノンの化学発光分析法2012
- Author(s)
  岸川直哉、下舞千香子、Elgawish Mohamed Saleh、大山要、中島憲一郎、黒田直敬
- Organizer
  第72回分析化学討論会
- Place of Presentation
  鹿児島
- Year and Date
  2012-05-19
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] 早期関節リウマチ患者のイムノコンプレキソーム解析2012
- Author(s)
  大山要,馬場雅子,川上純,玉井慎美,岸川直哉,植木幸孝,上平憲,中島憲一郎,黒田直敬
- Organizer
  第23回日本臨床化学会九州支部総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] イムノコンプレキソーム解析法におけるペプチド分離およびトリプシン消化の最適化2012
- Author(s)
  馬場雅子,大山要,岸川直哉,黒田直敬
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] 免疫疾患に関連する免疫複合体抗原のスクリーニングへのイムノコンプレキソーム解析法の応用2012
- Author(s)
  大山要,川上純,玉井慎美,馬場雅子,岸川直哉,黒田直敬
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Year and Date
  2012-11-24
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] 免疫疾患に関連する免疫複合体抗原のスクリーニングへのイムノコンプレキソーム解析法の応用2012
- Author(s)
  大山要,川上純,玉井慎美,馬場雅子,岸川直哉,黒田直敬
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790158
[Presentation] パーキンソン病誘発物質MPP+のSIA/紫外線照射/化学発光検出2012
- Author(s)
  樋口翔,岸川直哉,大山要,中島憲一郎,黒田直敬
- Organizer
  第29回日本薬学会九州支部大会
- Place of Presentation
  熊本
- Year and Date
  2012-12-09
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] シーケンシャルインジェクションに基づくパーキンソン病誘発物質MPP^+の全自動化学発光分析法の開発2012
- Author(s)
  樋口翔、岸川直哉、大山要、中島憲一郎、黒田直敬
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] 早期関節リウマチ患者のイムノコンプレキソーム解析2012
- Author(s)
  大山要、馬場雅子、川上純, 他
- Organizer
  第23回日本臨床化学会九州支部総会
- Place of Presentation
  福岡市
- Year and Date
  2012-02-11
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] パラコートのオンサイト分析を目的とするルミノール化学発光定量法の開発2011
- Author(s)
  樋口翔、岸川直哉、大山要、中島憲一郎、黒田直敬
- Organizer
  日本法中毒学会第30年会
- Place of Presentation
  長崎大学
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] 慢性関節リウマチ患者血清のLC-MS/ MSによるイムノコンプレキソーム解析2011
- Author(s)
  大山要, 植木幸孝, 川上純, 岸川直哉, 上平憲, 中島憲一郎, 黒田直敬
- Organizer
  第18回クロマトグラフィーシンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] 慢性関節リウマチ患者血清のLC-MS/MSによるイムノコンプレキソーム解析2011
- Author(s)
  大山要、植木幸孝、川上純, 他
- Organizer
  第18回クロマトグラフィーシンポジウム
- Place of Presentation
  福岡市
- Year and Date
  2011-06-02
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] Microplate analytical method for quinones by pulse photo-irradiation and chemiluminscence detection2011
- Author(s)
  Mohamed Saleh Elgawish、下舞千香子、岸川直哉、大山要、中島憲一郎、黒田直敬
- Organizer
  生物発光化学発光研究会第28回学術講演会
- Place of Presentation
  長崎大学
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] Microplate analytical method for quinines by pulse photo-irradiation and chemiluminescence detection2011
- Author(s)
  Elgawish MS, Shimomai C, Kishikawa N, Ohyama K, Nakashima K, Kuroda N
- Organizer
  生物発光化学発光研究会第28回学術講演会
- Place of Presentation
  長崎
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] パーキンソン病誘発物質 MPP+のシーケンシャルインジェクション化学発光分析法の開発2011
- Author(s)
  樋口翔,岸川直哉,大山要,中島憲一郎,黒田直敬
- Organizer
  生物発光化学発光研究会第28回学術講演会
- Place of Presentation
  長崎
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] 関節リウマチ患者血清のLC-MS/MSによるイムノコンプレキソーム解析2011
- Author(s)
  川上　純，大山　要，植木幸孝，玉井慎美，中村英樹，岸川直哉，上平　憲，中島憲一郎，黒田直敬
- Organizer
  第26回日本臨床リウマチ学会
- Place of Presentation
  神奈川（横浜）
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] パーキンソン病誘発物質MPP+のシーケンシャルインジェクション化学発光分析法の開発2011
- Author(s)
  樋口翔、岸川直哉、大山要、中島憲一郎、黒田直敬
- Organizer
  生物発光化学発光研究会第28回学術講演会
- Place of Presentation
  長崎大学
- Year and Date
  2011-10-08
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] 関節リウマチ患者血清のLC-MS/MSによるイムノコンプレキソーム解析2011
- Author(s)
  川上純,大山要,植木幸孝,玉井慎美,中村英樹,岸川直哉,上平憲,中島憲一郎,黒田直敬
- Organizer
  第26回日本臨床リウマチ学会
- Place of Presentation
  神奈川(横浜)
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] パラコートのオンサイト分析を目的とするルミノール化学発光定量法の開発2011
- Author(s)
  樋口翔,岸川直哉,大山要,中島憲一郎,黒田直敬
- Organizer
  日本法中毒学会第30年会
- Place of Presentation
  長崎
- Year and Date
  2011-06-10
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] Characterization of peptide chiral selectors prepared by solid-phase synthesis in HPLC enantioseparation.2010
- Author(s)
  Kaname Ohyama, et al
- Organizer
  22^<th> International Symposium on Chirality
- Place of Presentation
  札幌
- Year and Date
  2010-07-14
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] 血清アルブミンに対する発蛍光測定試薬を用いる血清中酸化・還元アルブミン比の測定法の開発2010
- Author(s)
  岸川直哉、大山要、黒田直敬, 他
- Organizer
  第50回日本臨床化学会年次学術集会
- Place of Presentation
  山梨県立県民文化ホール
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] リウマチ患者血清中ビタミンK類の光誘起ルミノール化学発光定量2010
- Author(s)
  岸川直哉、大山要、黒田直敬, 他
- Organizer
  日本分析化学会第59年会
- Place of Presentation
  東北大学
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] メタクリル酸をイオン性モノマーとするCEC用モノリスカラムの評価2010
- Author(s)
  大山要, 堀口大輔, 岸川直哉, 中島憲一郎, 黒田直敬
- Organizer
  第21回クロマトグラフィー科学会議
- Place of Presentation
  西宮
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] リウマチ患者血清中ビタミン K 類の光誘起ルミノール化学発光定量2010
- Author(s)
  岸川直哉,Sameh Ahmed,大山要,今里孝宏,植木幸孝,中島憲一郎,黒田直敬
- Organizer
  日本分析化学会第59年会
- Place of Presentation
  仙台
- Year and Date
  2010-09-17
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] Suzuki coupling反応を利用するクロルフェニラミン及び代謝物のHPLC-過シュウ酸エステル化学発光定量法の開発2010
- Author(s)
  岸川直哉、大山要、黒田直敬, 他
- Organizer
  第17回クロマトグラフィーシンポジウム
- Place of Presentation
  広島県情報広場
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] 血清アルブミンに対する発蛍光測定試薬を用いる血清中酸化・還元アルブミン比の測定法の開発2010
- Author(s)
  岸川直哉,大山要,今里孝宏,中島憲一郎,前畑英介,黒田直敬
- Organizer
  第50回日本臨床化学会年次学術集会
- Place of Presentation
  甲府
- Year and Date
  2010-09-24
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] Suzuki coupling 反応を利用するクロルフェニラミン及び代謝物の HPLC-過シュウ酸エステル化学発光定量法の開発2010
- Author(s)
  岸川直哉,Adutwum Lawrence Asamoah,大山要,中島憲一郎,黒田直敬
- Organizer
  第17回クロマトグラフィーシンポジウム
- Place of Presentation
  広島
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] Selective determination of ubiquinone in human plasma by HPLC with a chemiluminescence reaction based on the redox cycle of quinone2010
- Author(s)
  Kuroda N, Ohkubo N, Kishikawa N, Ohyama K, Nakashima K
- Organizer
  XIV. International Symposium on Luminescence Spectrometry.
- Place of Presentation
  Prague, Czech Republic
- Year and Date
  2010-07-14
- Data Source
  KAKENHI-PROJECT-22390116
[Presentation] Characterization of peptide chiral selectors prepared by solid-phase synthesis in HPLC enantioseparation2010
- Author(s)
  K. Ohyama, K. Oyamada, N. Kishikawa, Y. Ohba, M. Wada, K. Nakashima, N. Kuroda
- Organizer
  22^〈th〉International Symposium on Chirality
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-22790160
[Presentation] 免疫疾患に関連する免疫複合体抗原のスクリーニングへのイムノコンプレキソーム解析法の応用
- Author(s)
  大山　要，川上　純，玉井慎美，馬場雅子，岸川直哉，黒田直敬
- Organizer
  第6回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-23591439
[Presentation] イムノコンプレキソーム解析による自己免疫疾患患者の抗原プロファイリング
- Author(s)
  大山　要，馬場雅子，玉井慎美，一瀬邦弘，岸川直哉，川上　純，黒田直敬
- Organizer
  第24回日本臨床化学会九州支部総会
- Place of Presentation
  沖縄
- Data Source
  KAKENHI-PROJECT-23591439

1. KAWAKAMI Atsushi (90325639)

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OHYAMA Kaname 大山 要

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プロテオミクス x 機能的MRI x AIで導く「ゲーム依存の視える化」と社会実装研究Principal Investigator

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Challenge to "visualize mental illness" to realize a symbiotic society with illnessPrincipal Investigator

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Can we prevent the social penetration of gaming disorder? Basic research for integrated scientific evaluation and early countermeasures against gaming disorderPrincipal Investigator

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Construction of preemptive medicine for rheumatoid arthritis based on proteomics and artificial intelligence of a medical examination cohortPrincipal Investigator

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OHYAMA Kaname 大山要