FUKUZAWA KAORI 福澤薫 (秋葉薫)

… Alternative Names

秋葉薫

Fukuzawa Kaori 福澤薫

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Researcher Number	50718244
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2022 – 2025: 大阪大学, 大学院薬学研究科, 教授 2016 – 2017: 星薬科大学, 薬学部, 准教授 2015: 日本大学, 松戸歯学部, 助教
Review Section/Research Field	Principal Investigator Physical chemistry Except Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Basic Section 49060:Virology-related / Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Keywords	Principal Investigator 温度因子 / 生体高分子 / 熱揺らぎ / 構造解析 / 創薬 / 熱ゆらぎ / 構造最適化 / 電子密度 / 構造生命科学 / リガンド結合 … More / タンパク質 / 量子化学計算 / 超分解能解析 / 構造精密化 / 電子密度解析 / 計算構造生物学 / 創薬分子設計 / フラグメント分子軌道法 … More Except Principal Investigator フラグメント分子軌道法 / 阻害剤 / 糖鎖創薬 / ヘパラナーゼ / アトピー性皮膚炎 / 基底膜細胞外マトリックス / FMO / MD / ヘルペスウイルス / クライオ電顕 / 中分子薬物 / 安定性 / 吸収性 / ナノ粒子 / 非晶質 / 皮膚疾患 / コンドロイチン硫酸 / 酵素阻害物質 / ターゲッティング / 融合タンパク質 / 抗体複合体 / へパリン / ヒアルロン酸 / 酵素阻害剤 Less

クライオ電子顕微鏡を用いたヘルペスウイルスDNA複製の構造基盤解明
- Principal Investigator
  
  仙石徹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Yokohama City University
アトピー性皮膚炎皮疹部の基底膜構造正常化と掻痒感緩和に向けた糖連結機能分子の創出
- Principal Investigator
  
  東伸昭
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hoshi University
Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug development
- Principal Investigator
  
  東顕二郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Chiba University
Design of heparanase inhibitors focusing on molecular bending and competitive interaction: aiming to suppress skin inflammatory diseases
- Principal Investigator
  
  東伸昭
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hoshi University
Development of super-resolution structure analysis techniques for bio-macromolecules based on a quantum chemical calculationPrincipal Investigator
- Principal Investigator
  
  Fukuzawa Kaori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Physical chemistry
- Research Institution
  Hoshi University
  Nihon University

All 2023 2022 2018 2017 2016 2015

All Journal Article Presentation Book

[Book] in silico創薬におけるスクリーニング技術の高速化・高精度化技術　第２章第１１節「スーパーコンピュータを用いたFMO研究の実際」2018
- Author(s)
  福澤　薫
- Total Pages
  3
- Publisher
  技術情報協会
- Data Source
  KAKENHI-PROJECT-15K05397
[Journal Article] Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells.2022
- Author(s)
  Shi J, Kanoya R, Tani Y, Ishikawa S, Maeda R, Suzuki S, Kawanami F, Miyagawa N, Takahashi K, Oku T, Yamamoto A, Fukuzawa K, Nakajima M, Irimura T, Higashi N.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 23 Issue: 9 Pages: 5055-5055
- DOI
  10.3390/ijms23095055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06587, KAKENHI-PROJECT-19K07091
[Journal Article] Application of singular value decomposition to the inter-fragment interaction energy analysis for ligand screening2018
- Author(s)
  Maruyama Keiya、Sheng Yinglei、Watanabe Hirofumi、Fukuzawa Kaori、Tanaka Shigenori
- Journal Title
  
  Computational and Theoretical Chemistry
  
  Volume: 1132 Pages: 23-34
- DOI
  10.1016/j.comptc.2018.04.001
- NAID
  120006482609
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05397, KAKENHI-PROJECT-18K03825, KAKENHI-PLANNED-17H06353
[Journal Article] Fragment Molecular Orbital Calculations with Implicit Solvent Based on the Poisson?Boltzmann Equation: Implementation and DNA Study2018
- Author(s)
  Okiyama Yoshio、Nakano Tatsuya、Watanabe Chiduru、Fukuzawa Kaori、Mochizuki Yuji、Tanaka Shigenori
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 122 Issue: 16 Pages: 4457-4471
- DOI
  10.1021/acs.jpcb.8b01172
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05397, KAKENHI-PROJECT-18K03825, KAKENHI-PLANNED-17H06353
[Journal Article] Hydration of Ligands of Influenza Virus Neuraminidase Studied by the Fragment Molecular Orbital Method2017
- Author(s)
  K. Tokuda, C. Watanabe, Y. Okiyama, Y. Mochizuki, K. Fukuzawa and Y. Komeiji
- Journal Title
  
  J. Mol. Graph. Model
  
  Volume: 69 Pages: 144-153
- DOI
  10.1016/j.jmgm.2016.08.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05397
[Journal Article] Solubility improvement of epalrestat by layered structure formation via cocrystallization2017
- Author(s)
  O. D. Putra, D. Umeda, Y. P. Nugraha, T. Furuishi, K. Fukuzawa, H. Nagase, H. Uekusa
- Journal Title
  
  CrystEngComm
  
  Volume: 19 Issue: 19 Pages: 2614-2622
- DOI
  10.1039/c7ce00284j
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460048, KAKENHI-PROJECT-15K05397
[Journal Article] Theoretical Analysis of Activity Cliffs among Benzofuranone Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach2017
- Author(s)
  C. Watanabe, H. Watanabe, K. Fukuzawa, L. Parker, Y. Okiyama, H. Yuki, S. Yokoyama, H. Nakano, S. Tanaka, T. Honma
- Journal Title
  
  J. Chem. Inf. Model.
  
  Volume: 57 Issue: 12 Pages: 2996-3010
- DOI
  10.1021/acs.jcim.7b00110
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-17H06353, KAKENHI-PROJECT-15K05397
[Journal Article] 量子論に基づくタンパク質―化学物質相互作用解析～FMO創薬の実現に向けた取り組み2017
- Author(s)
  福澤薫
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 149 Pages: 240-246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05397
[Journal Article] Explicit solvation of a single-stranded DNA, a binding protein, and their complex: a suitable protocol for fragment molecular orbital calculation2017
- Author(s)
  古明地勇人、沖山佳生、望月祐志、福澤薫
- Journal Title
  
  Chem-Bio Informatics Journal
  
  Volume: 17 Issue: 0 Pages: 72-84
- DOI
  10.1273/cbij.17.72
- NAID
  130005874045
- ISSN
  1347-0442, 1347-6297
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05397
[Journal Article] Fragment molecular orbital (FMO) calculations on DNA by a scaled third-order Møller-Plesset perturbation (MP2.5) scheme2017
- Author(s)
  H. Yamada, Y. Mochizuki, K. Fukuzawa, Y. Okiyama and Y. Komeiji
- Journal Title
  
  Comp. Theor. Chem
  
  Volume: 1101 Pages: 46-54
- DOI
  10.1016/j.comptc.2016.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K05397
[Journal Article] FMO創薬を加速する大規模データ解析2017
- Author(s)
  田中成典、福澤薫、本間光貴
- Journal Title
  
  CICSJ Bulletin
  
  Volume: 35 Issue: 3 Pages: 205
- DOI
  10.11546/cicsj.35.205
- NAID
  130006792848
- ISSN
  0913-3747, 1347-2283
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K05397
[Journal Article] Fragment Molecular Orbital (FMO) Calculations of Peptoids2016
- Author(s)
  川田修太郎、坂口正貴、米倉伊吹、奥脇弘次、望月祐志、福澤薫
- Journal Title
  
  J. Comput. Chem. Jpn.
  
  Volume: 15 Issue: 3 Pages: 51-52
- DOI
  10.2477/jccj.2016-0032
- NAID
  130005605870
- ISSN
  1347-1767, 1347-3824
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] 硫酸化ヒアルロン酸によるヘパラナーゼ阻害作用の構造的基盤2023
- Author(s)
  東伸昭、史佳、彼ノ矢陸、谷祐里菜、石川壮大、高橋勝彦、奥輝明、山本亜美、福澤薫、中島元夫、入村達郎
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K06587
[Presentation] フラグメント分子軌道法によるエストロゲン受容体βとリガンドとの相互作用解析2018
- Author(s)
  関祐哉、加藤司、郡司美穂子、古石誉之、福澤薫、米持悦生
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] フラグメント分子軌道法を用いたインシリコ創薬基盤技術の開発2017
- Author(s)
  福澤薫
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] ベンズブロマロンとイソニコチンアミドの分子複合体化の検討2017
- Author(s)
  浜口慧太朗、古石誉之、郡司美穂子、遠藤朋宏、福澤薫、長瀬弘昌、米持悦生
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] HPCIを活用したFMO創薬プラットフォームの構築2017
- Author(s)
  福澤薫
- Organizer
  第４回「京」を中核とするHPCIシステム利用研究課題成果報告会
- Invited
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] Development of In Silico Drug Design Techniques Based on the Fragment Molecular Orbital Method2017
- Author(s)
  Kaori Fukuzawa
- Organizer
  11th Triennial Congress of the World Association of Theoretical and Computational Chemist (WATOC2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] FMO創薬コンソーシアムにおける活動2017
- Author(s)
  福澤薫
- Organizer
  CBI学会2017年大会
- Invited
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] コール酸類との包接複合体形成に基づくCyclomaltononaose（δ -CD）生成率の改善2017
- Author(s)
  郡司美穂子, 西岡夏生, 小高玄渡, 渡邉茉莉子, 遠藤朋宏, 古石誉之, 福澤薫, 米持悦生
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] フラグメント分子軌道法によるエストロゲン受容体βとリガンドとの相互作用解析2017
- Author(s)
  関祐哉、加藤司、郡司美穂子、古石誉之、福澤薫、米持悦生
- Organizer
  第61回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] Construction of FMO IFIE-database2017
- Author(s)
  ChiduruWatanabe, Daisuke Takaya, ShunpeiNagase, Kikuko Kamisaka, Yoshio Okiyama, Kaori Fukuzawa, Teruki Honma
- Organizer
  CBI学会2017年大会
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] In silico Drug Discovery Based on the Fragment Molecular Orbital method2017
- Author(s)
  Kaori Fukuzawa
- Organizer
  Joint symposium for Zhejiang University
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] ハイドロキシアパタイト結晶表面における各種アミノ酸のシミュレーションによる挙動解析2016
- Author(s)
  加藤幸一郎，橋本彩, 福澤薫, 民谷栄一
- Organizer
  第77回応用物理学会秋季学術講演会
- Place of Presentation
  新潟
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] Singular Value Decomposition in the FMO-IFIE Analysis for Ligand Screening2016
- Author(s)
  Keiya Maruyama, Yinglei Sheng, Hirofumi Watanabe, Kaori Fukuzawa, Shigenori Tanaka
- Organizer
  CBI学会2016年次大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] 機械学習を援用したUbiquitin のアミノ酸残基間の相互作用解析2016
- Author(s)
  望月祐志，藤本真悠，古明地勇人，飯島潤，齊藤天菜，土居英男，奥沢明，牧村健，中西貴哉，福澤薫，田中成典
- Organizer
  第77回応用物理学会秋季学術講演会
- Place of Presentation
  新潟
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] 創薬分子設計におけるFMO法の役割2016
- Author(s)
  福澤薫
- Organizer
  第10回分子科学討論会
- Place of Presentation
  神戸
- Year and Date
  2016-09-13
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] フラグメント分子軌道法による生体高分子およびナノバイオ系の量子化学計算2016
- Author(s)
  福澤薫
- Organizer
  日本表面科学会　関東支部セミナー
- Place of Presentation
  東京
- Year and Date
  2016-11-26
- Invited
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] FMO創薬コンソーシアムFMO創薬コンソーシアムにおけるタンパク質－リガンド相互作用の高精度解析と創薬への応用2016
- Author(s)
  福澤薫
- Organizer
  バイオグリッド研究会2016
- Place of Presentation
  大阪
- Year and Date
  2016-05-28
- Invited
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] FMO創薬の実現に向けた取り組み2016
- Author(s)
  福澤薫
- Organizer
  CBI学会2016年次大会
- Place of Presentation
  東京
- Year and Date
  2016-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] FMO創薬の実現に向けた取り組み2016
- Author(s)
  Kaori Fukuzawa
- Organizer
  CBI学会2016年大会
- Place of Presentation
  タワーホール船堀（東京都・江戸川区）
- Year and Date
  2016-10-25
- Invited
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] Application of fragment molecular orbital method for structure-based drug design2015
- Author(s)
  Kaori Fukuzawa
- Organizer
  Pacifichem 2015
- Place of Presentation
  Honolulu (U.S.A.)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K05397
[Presentation] フラグメント分子軌道法の創薬への応用～FMO創薬の実現に向けて～2015
- Author(s)
  福澤　薫
- Organizer
  第43回構造活性相関シンポジウム
- Place of Presentation
  新潟日報メディアシップ（新潟県・新潟市）
- Year and Date
  2015-09-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K05397

1. 東伸昭 (40302616)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 小宮根真弓 (00282632)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 眞鍋史乃 (60300901)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HONMA Teruki (10466039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. TANAKA Shigenori (10379480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. TSURUTA Hiroki (20346282)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 東顕二郎 (40451760)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 森部久仁一 (50266350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 植田圭祐 (40755972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 米持悦生 (40201090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 仙石徹 (60576312)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 河野秀俊 (40291918)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. WATANABE Chiduru

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

FUKUZAWA KAORI 福澤 薫 (秋葉 薫)

秋葉薫

Fukuzawa Kaori 福澤 薫

Research Projects

Research Products

Co-Researchers

クライオ電子顕微鏡を用いたヘルペスウイルスDNA複製の構造基盤解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アトピー性皮膚炎皮疹部の基底膜構造正常化と掻痒感緩和に向けた糖連結機能分子の創出

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug development

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Design of heparanase inhibitors focusing on molecular bending and competitive interaction: aiming to suppress skin inflammatory diseases

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of super-resolution structure analysis techniques for bio-macromolecules based on a quantum chemical calculationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] in silico創薬におけるスクリーニング技術の高速化・高精度化技術 第２章第１１節「スーパーコンピュータを用いたFMO研究の実際」2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of singular value decomposition to the inter-fragment interaction energy analysis for ligand screening2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Fragment Molecular Orbital Calculations with Implicit Solvent Based on the Poisson?Boltzmann Equation: Implementation and DNA Study2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hydration of Ligands of Influenza Virus Neuraminidase Studied by the Fragment Molecular Orbital Method2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Solubility improvement of epalrestat by layered structure formation via cocrystallization2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Theoretical Analysis of Activity Cliffs among Benzofuranone Class Pim1 Inhibitors Using the Fragment Molecular Orbital Method with Molecular Mechanics Poisson-Boltzmann Surface Area (FMO+MM-PBSA) Approach2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 量子論に基づくタンパク質―化学物質相互作用解析～FMO創薬の実現に向けた取り組み2017

Author(s)

Journal Title

Data Source

[Journal Article] Explicit solvation of a single-stranded DNA, a binding protein, and their complex: a suitable protocol for fragment molecular orbital calculation2017

Author(s)

Journal Title

DOI

FUKUZAWA KAORI 福澤薫 (秋葉薫)

Fukuzawa Kaori 福澤薫

[Book] in silico創薬におけるスクリーニング技術の高速化・高精度化技術　第２章第１１節「スーパーコンピュータを用いたFMO研究の実際」2018

[Journal Article] Fragment molecular orbital (FMO) calculations on DNA by a scaled third-order Møller-Plesset perturbation (MP2.5) scheme2017