Fujihira Haruhiko 藤平陽彦

Researcher Number	50721057
Other IDs
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 開拓研究所, 研究員 2025: 順天堂大学, 大学院医学研究科, 非常勤助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 順天堂大学, 大学院医学研究科, 非常勤助教 2021 – 2023: 国立研究開発法人理化学研究所, 開拓研究本部, 研究員 2018 – 2019: 順天堂大学, 医学(系)研究科(研究院), 特任助教 2017: 順天堂大学, 医学(系)研究科(研究院), 特任研究員 2017: 順天堂大学, 医学部, 特任研究員 2016: 順天堂大学, 医学部, 博士研究員
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Functional biochemistry Except Principal Investigator Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator 糖鎖脱離酵素 / Ngly1 / トリプルネガティブ乳がん / 薬剤耐性 / TNBC / NGLY1 / NEF2L1 (Nrf1) / 造血発生 / 細胞質における糖鎖分解 / マウス造血発生 … More / Nfe2l1 / オートファジー / ユビキチン・プロテアソーム / Autophagy / ERAD / PNGase / autophagy / ubiquitin-proteasome / ENGase … More Except Principal Investigator 糖鎖分子 / 薬剤耐性 / 肺癌 Less

The importance of NGLY1 on the chemoresistance of triple negative breast cancerPrincipal Investigator
- Principal Investigator
  
  Fujihira Haruhiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Institute of Physical and Chemical Research
肺癌における糖鎖分子を標的としたEGFR-TKI耐性克服の試み
- Principal Investigator
  
  高橋史行
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Juntendo University
Revealing a role of cytoplasmic de-glycosylation in the erythropoiesisPrincipal Investigator
- Principal Investigator
  
  Fujihira Haruhiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Juntendo University
Revealing the physiological function of de-N-glycosylating enzymes in micePrincipal Investigator
- Principal Investigator
  
  Fujihira Haruhiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Juntendo University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases2024
- Author(s)
  Horimoto Yoshiya、Hlaing May Thinzar、Saeki Harumi、Denda-Nagai Kaori、Ishii-Schrade Katrin、Fujihira Haruhiko、Abe Masaaki、Noji Miki、Shichino Shigeyuki、Saito Mitsue、Irimura Tatsuro
- Journal Title
  
  Clinical & Experimental Metastasis
  
  Volume: 41 Issue: 3 Pages: 267-270
- DOI
  10.1007/s10585-023-10253-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07163, KAKENHI-PROJECT-23K06241, KAKENHI-PROJECT-21K06092, KAKENHI-PLANNED-22H05064
[Journal Article] ELISA-based highly sensitive assay system for the detection of endogenous NGLY1 activity2024
- Author(s)
  Fujihira Haruhiko、Sato Keiko、Nishiuchi Yuji、Murase Takefumi、Matsuda Yuka、Yoshida Yukiko、Kamei Takayuki、Suzuki Tadashi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 710 Pages: 149826-149826
- DOI
  10.1016/j.bbrc.2024.149826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06092, KAKENHI-PROJECT-23K23571
[Journal Article] NGLY1: A fascinating, multifunctional molecule2024
- Author(s)
  Suzuki Tadashi、Fujihira Haruhiko
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1868 Issue: 2 Pages: 130379-130379
- DOI
  10.1016/j.bbagen.2023.130379
- Data Source
  KAKENHI-PROJECT-21K06092
[Journal Article] Occurrence of free N-glycans with a single GlcNAc at the reducing termini in animal sera2021
- Author(s)
  Huang Chengcheng、Seino Junichi、Fujihira Haruhiko、Sato Keiko、Fujinawa Reiko、Sumer-Bayraktar Zeynep、Ishii Nozomi、Matsuo Ichiro、Nakaya Shuichi、Suzuki Tadashi
- Journal Title
  
  Glycobiology
  
  Volume: 32 Issue: 4 Pages: 314-332
- DOI
  10.1093/glycob/cwab124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06290, KAKENHI-PROJECT-21K06092
[Journal Article] Physiological importance of NGLY1, as revealed by rodent model analyses2021
- Author(s)
  Fujihira Haruhiko、Asahina Makoto、Suzuki Tadashi
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 171 Issue: 2 Pages: 161-167
- DOI
  10.1093/jb/mvab101
- Data Source
  KAKENHI-PROJECT-21K06092
[Journal Article] Bisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epithelioid mesothelioma cells2021
- Author(s)
  Fujihira Haruhiko、Takakura Daisuke、Matsuda Atsushi、Abe Masaaki、Miyazaki Michiyo、Nakagawa Tomomi、Kajino Kazunori、Denda-Nagai Kaori、Noji Miki、Hino Okio、Irimura Tatsuro
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 170 Issue: 3 Pages: 317-326
- DOI
  10.1093/jb/mvab044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07163, KAKENHI-PROJECT-21K06092
[Journal Article] Glycans unique to the relapse-prone subset within triple-negative breast cancer as revealed by lectin array-based analysis of surgical specimens2021
- Author(s)
  Sakata-Matsuzawa Madoka、Denda-Nagai Kaori、Fujihira Haruhiko、Noji Miki、Ishii-Schrade Katrin Beate、Matsuda Atsushi、Kuno Atsushi、Okazaki Misato、Nakai Katsuya、Horimoto Yoshiya、Saito Mitsue、Irimura Tatsuro
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 5 Pages: e0250747-e0250747
- DOI
  10.1371/journal.pone.0250747
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07163, KAKENHI-PROJECT-21K06092
[Journal Article] Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress2020
- Author(s)
  Fujihira Haruhiko、Masahara-Negishi Yuki、Akimoto Yoshihiro、Hirayama Hiroto、Lee Hyeon-Cheol、Story Benjamin A.、Mueller William F.、Jakob Petra、Clauder-M?nster Sandra、Steinmetz Lars M.、Radhakrishnan Senthil K.、Kawakami Hayato、Kamada Yoshihiro、Miyoshi Eiji、Yokomizo Takehiko、Suzuki Tadashi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  
  Volume: 1866 Issue: 3 Pages: 165588-165588
- DOI
  10.1016/j.bbadis.2019.165588
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06840, KAKENHI-ORGANIZER-15H05897, KAKENHI-PLANNED-15H05904, KAKENHI-PROJECT-18K14655, KAKENHI-PROJECT-19KK0199, KAKENHI-PROJECT-19H03562, KAKENHI-PROJECT-18H02627, KAKENHI-PROJECT-18H03990
[Journal Article] Physiological Function of the Cytosolic Peptide:<i>N</i>-glycanase (Ngly1)2019
- Author(s)
  Haruhiko Fujihira
- Journal Title
  
  Trends in Glycoscience and Glycotechnology
  
  Volume: 31 Issue: 179 Pages: E33-E39
- DOI
  10.4052/tigg.1756.1E
- NAID
  130007618604
- ISSN
  0915-7352, 1883-2113
- Year and Date
  2019-03-25
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14655
[Journal Article] N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1.2018
- Author(s)
  Kun Yang, Ryan Huang, Haruhiko Fujihira, Tadashi Suzuki, Nan Yan
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 215(10) Issue: 10 Pages: 2600-2616
- DOI
  10.1084/jem.20180783
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14655, KAKENHI-PROJECT-18H03990
[Journal Article] A Critical Domain of Ebolavirus Envelope Glycoprotein Determines Glycoform and Infectivity2018
- Author(s)
  Fujihira H, Usami K, Matsuno K, Takeuchi H, Denda-Nagai K, Furukawa JI, Shinohara Y, Takada A, Kawaoka Y, Irimura T
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 5495-5495
- DOI
  10.1038/s41598-018-23357-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670023, KAKENHI-PROJECT-16K18520, KAKENHI-PROJECT-18K14655, KAKENHI-PROJECT-16H02627, KAKENHI-PROJECT-16K05804
[Journal Article] Lethality of mice bearing a knockout of the Ngly1-gene is rescued by the additional deletion of the Engase gene.2017
- Author(s)
  Fujihira H., Masahara-Negishi Y., Tamura M., Harada Y., Chengcheng H., Wakana S., Taniguchi N., Kondoh G., Yamashita T., Funakoshi Y. and Suzuki T.
- Journal Title
  
  PLOS Genetics
  
  Volume: 13 Issue: 4 Pages: 1-23
- DOI
  10.1371/journal.pgen.1006696
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06815, KAKENHI-PROJECT-16K18520, KAKENHI-PROJECT-15H04700
[Journal Article] するべきこと，してはいけないこと．2017
- Author(s)
  藤平陽彦、鈴木匡
- Journal Title
  
  生化学
  
  Volume: 89 Issue: 5 Pages: 599-599
- DOI
  10.14952/SEIKAGAKU.2017.890599
- ISSN
  0037-1017
- Year and Date
  2017-10-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18520
[Presentation] 簡便で高感度なNGLY1活性測定システム2023
- Author(s)
  藤平陽彦、佐藤敬子、西内祐二、村瀬健文、松田由佳、亀井孝幸、鈴木匡
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06092
[Presentation] トリプルネガティブ乳がんの薬剤耐性とNGLY1の関連性2022
- Author(s)
  藤平陽彦、堀本義哉、鈴木匡
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06092
[Presentation] トリプルネガティブ乳がんにおけるNGLY1の役割2021
- Author(s)
  藤平陽彦、堀本義哉、鈴木匡
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06092
[Presentation] トリプルネガティブ乳がんにおけるNGLY1の役割2021
- Author(s)
  藤平陽彦、堀本義哉、鈴木匡
- Organizer
  第40回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-21K06092
[Presentation] 細胞質での糖鎖分解の生物における重要性2019
- Author(s)
  藤平陽彦、根岸-正原由紀、船越陽子、鈴木匡
- Organizer
  第5回糖鎖免疫研究会
- Data Source
  KAKENHI-PROJECT-18K14655
[Presentation] マウス成体肝臓におけるNgly1の重要性2019
- Author(s)
  藤平陽彦
- Organizer
  第38回日本糖質学会年会
- Data Source
  KAKENHI-PROJECT-18K14655
[Presentation] The defects caused by the loss of Ngly1 can be partially rescued by the additional deletion of Engase2018
- Author(s)
  Haruhiko Fujihira, Yuki Masahara-Negishi, Masaru Tamura, Shigeharu Wakana, Daisuke Takakura, Nana Kawasaki, Yoko Funakoshi, Tadashi Suzuki
- Organizer
  International Symposium on ER Stress, glycosylation, homeostasis and diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18520
[Presentation] 肝臓におけるNgly1の生理機能2018
- Author(s)
  藤平陽彦、根岸-正原由紀、秋元義弘、川上速人、船越陽子、鈴木匡
- Organizer
  第91回日本生化学大会
- Data Source
  KAKENHI-PROJECT-18K14655
[Presentation] Engase欠損により回避可能/不可能なNgly1-KOマウスの表現型2017
- Author(s)
  藤平陽彦
- Organizer
  第3回 ENGase研究会
- Data Source
  KAKENHI-PROJECT-16K18520
[Presentation] Engase欠損により回避可能/不可能なNgly1欠損による異常2017
- Author(s)
  藤平陽彦、根岸-正原由紀、田村勝、高倉大輔、黄澄澄、若菜茂晴、川崎ナナ、船越陽子、鈴木匡
- Organizer
  2017年度生命科学系学会合同年次大会(ConBio2017)
- Data Source
  KAKENHI-PROJECT-16K18520
[Presentation] Summary of phenotypic analyses of Ngly1-KO mice and Ngly1/Engase-KO mice2017
- Author(s)
  Haruhiko Fujihira, Yuki Masahara-Negishi, Masaru Tamura, Shigeharu Wakana, Daisuke Takakura, Nana Kawasaki, Yoko Funakoshi, Tadashi Suzuki
- Organizer
  International Syposium “Systems Glycobiology and Beyond”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18520
[Presentation] Physiological function of deglycosylating enzymes acting on N-glycans in mice2016
- Author(s)
  Haruhiko Fujihira, Yuki Masahara-Negishi, Masaru Tamura, Shigeharu Wakana, Daisuke Takakura, Nana Kawasaki, Yoko Funakoshi, Tadashi Suzuki
- Organizer
  Frontiers 2016 symposium
- Place of Presentation
  EPFL (Ecole Polytechnique Federale de Lausanne) (Switzerland)
- Year and Date
  2016-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18520

1. 堀本義哉 (40424246)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 高橋史行 (70327823)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 田島健 (50384102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 高橋和久 (80245711)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 秋元義弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 傅田香里

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 田村勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 松尾一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 入村達郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujihira Haruhiko 藤平 陽彦

Research Projects

Research Products

Co-Researchers

The importance of NGLY1 on the chemoresistance of triple negative breast cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

肺癌における糖鎖分子を標的としたEGFR-TKI耐性克服の試み

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Revealing a role of cytoplasmic de-glycosylation in the erythropoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Revealing the physiological function of de-N-glycosylating enzymes in micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Glycosylation profiles of breast cancer cells may represent clonal variations of multiple organ metastases2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ELISA-based highly sensitive assay system for the detection of endogenous NGLY1 activity2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NGLY1: A fascinating, multifunctional molecule2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Occurrence of free N-glycans with a single GlcNAc at the reducing termini in animal sera2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physiological importance of NGLY1, as revealed by rodent model analyses2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bisecting-GlcNAc on Asn388 is characteristic to ERC/mesothelin expressed on epithelioid mesothelioma cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glycans unique to the relapse-prone subset within triple-negative breast cancer as revealed by lectin array-based analysis of surgical specimens2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stress2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Physiological Function of the Cytosolic Peptide:<i>N</i>-glycanase (Ngly1)2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1.2018

Author(s)

Journal Title

Fujihira Haruhiko 藤平陽彦