Im Dohyun ＩｍＤｏｈｙｕｎ

… Alternative Names

林到ヒョンイムドヒョン

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Researcher Number	50721883
Other IDs	https://orcid.org/0000-0002-6939-7718
Affiliation (Current)	2026: 京都産業大学, 生命科学部, 准教授 2026: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2026: 京都大学, 医学研究科, 特定准教授 2024 – 2025: 京都大学, 生命科学研究科, 助教 2023 – 2024: 京都大学, 医学研究科, 特定助教 2015 – 2017: 京都大学, 医学研究科, 特定研究員
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 48030:Pharmacology-related / Neurochemistry/Neuropharmacology Except Principal Investigator Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Basic Section 48040:Medical biochemistry-related
Keywords	Principal Investigator GPCR / SBDD / 創薬 / 薬理学 / 構造生物学 / Cryo-EM / 統合失調症 / 抗精神薬 / D2R / ドパミン受容体 … More / 結晶構造解析 / 神経伝達物質・受容体 / 膜蛋白質 / 膜タンパク質 / X線結晶構造解析 / Gタンパク質共役受容体 … More Except Principal Investigator クライオ電子顕微鏡 / Gタンパク質共役受容体 / 抗体 / 創薬 / 膜タンパク質 / 構造生物学 / リガンド開発 / 計算科学 / クライオ電子顕微鏡単粒子解析 / プロテアーゼ活性化受容体 / バイスシグナリング / 単粒子解析 / バイアスシグナリング / グレリン受容体 Less

ドパミン受容体におけるバイアスシグナルの構造基盤解明Principal Investigator
- Principal Investigator
  
  Im Dohyun
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Kyoto University
プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Kyoto University
膜蛋白質のクライオ電子顕微鏡システマティック解析を可能にするアプローチ
- Principal Investigator
  
  岩田想
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
A new mechanism of drug selectivity for dopamine receptorPrincipal Investigator
- Principal Investigator
  
  林到ヒョン
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Kyoto University
グレリン受容体のシグナル伝達選択機構の構造基盤
- Principal Investigator
  
  浅田秀基
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Kyoto University
Structural Study of Human Dopamine D2 ReceptorPrincipal Investigator
- Principal Investigator
  
  Im Dohyun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Kyoto University

All 2025 2024 2023 2018 2017

All Journal Article Presentation Book

[Book] 医学のあゆみ-統合失調症の未来 ─研究と治療2023
- Author(s)
  林到炫、岩田想
- Total Pages
  7
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-23K06357
[Journal Article] Time-resolved small-angle X-ray scattering system development for the biological macromolecules at SACLA: A pilot study2025
- Author(s)
  Shimizu Nobutaka、Luo Fangjia、Tanaka Tomoyuki、Tono Kensuke、Yatabe Keiko、Iwata So、Nango Eriko
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 22 Issue: 2 Pages: n/a
- DOI
  10.2142/biophysico.bppb-v22.0007
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K21945
[Journal Article] The structure and function of the ghrelin receptor coding for drug actions2025
- Author(s)
  Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho
- Journal Title
  
  Nature Structural and Molecular Biology
  
  Volume: 32 Issue: 3 Pages: 531-542
- DOI
  10.1038/s41594-024-01481-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24K01965, KAKENHI-PROJECT-24K01984, KAKENHI-PROJECT-22K06117, KAKENHI-PROJECT-23K06357, KAKENHI-PROJECT-23K18292, KAKENHI-PROJECT-24K21945, KAKENHI-PROJECT-22KK0099
[Journal Article] Discovering key activation hotspots in the M2 muscarinic receptor2025
- Author(s)
  Sugiura Yuya、Ikuta Tatsuya、Sumii Yuji、Tsujimoto Hirokazu、Suzuki Kohei、Suno Ryoji、Ariff Putri Nur Arina Binti Mohd、Iwata So、Shibata Norio、Inoue Asuka、Kobayashi Takuya、Kandori Hideki、Katayama Kota
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 147 Issue: 14 Pages: 11754-11765
- DOI
  10.1021/jacs.4c14385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04969, KAKENHI-PROJECT-23K21097, KAKENHI-PROJECT-24K02231, KAKENHI-PROJECT-24K21945
[Journal Article] Dual 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis2024
- Author(s)
  Oguma Takuya、Jino Kohei、Nakahara Kenji、Asada Hidetsugu、Fuchino Kouki、Nagatani Kotaro、Kouki Kensuke、Okamoto Ryuji、Takai Nozomi、Koda Ken、Fujita Sayaka、Sekiguchi Yusuke、Yasuo Kazuya、Mayumi Kei、Abe Ayane、Imono Masaaki、Horiguchi Naotaka、Iwata So、Kusakabe Ken-ichi
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 67 Issue: 16 Pages: 14478-14492
- DOI
  10.1021/acs.jmedchem.4c01244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24K21945, KAKENHI-PROJECT-22KK0099
[Journal Article] Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution2024
- Author(s)
  Miyata Yugo、Takahashi Katsuya、Lee Yongchan、Sultan Cheryl S.、Kuribayashi Risa、Takahashi Masatomo、Hata Kosuke、Bamba Takeshi、Izumi Yoshihiro、Liu Kehong、Uemura Tomoko、Nomura Norimichi、Iwata So、Nagata Shigekazu、Nishizawa Tomohiro、Segawa Katsumori
- Journal Title
  
  Nature Structural & Molecular Biology
  
  Volume: 32 Issue: 1 Pages: 185-198
- DOI
  10.1038/s41594-024-01411-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02682, KAKENHI-PLANNED-22H05185, KAKENHI-PROJECT-23K18239, KAKENHI-PROJECT-23KF0027, KAKENHI-PROJECT-23K27132, KAKENHI-PROJECT-23K27415, KAKENHI-PROJECT-23K05762, KAKENHI-PROJECT-24K21945
[Journal Article] Structural basis for hepatitis B virus restriction by a viral receptor homologue2024
- Author(s)
  Shionoya Kaho、Park Jae-Hyun、Ekimoto Toru、Takeuchi Junko S.、Mifune Junki、Morita Takeshi、Ishimoto Naito、Umezawa Haruka、Yamamoto Kenichiro、Kobayashi Chisa、Kusunoki Atsuto、Nomura Norimichi、Iwata So、Muramatsu Masamichi、Tame Jeremy R. H.、Ikeguchi Mitsunori、Park Sam-Yong、Watashi Koichi
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 9241-9241
- DOI
  10.1038/s41467-024-53533-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18239, KAKENHI-PROJECT-22KJ2816, KAKENHI-PROJECT-23K27415, KAKENHI-PROJECT-24K21945
[Journal Article] Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor2024
- Author(s)
  Araya Tsuyoshi、Matsuba Yuya、Suzuki Harufumi、Doura Tomohiro、Nuemket Nipawan、Nango Eriko、Yamamoto Masaki、Im Dohyun、Asada Hidetsugu、Kiyonaka Shigeki、Iwata So
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 695 Pages: 149393-149393
- DOI
  10.1016/j.bbrc.2023.149393
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0099, KAKENHI-PLANNED-19H05777, KAKENHI-PLANNED-19H05781, KAKENHI-PROJECT-19H00923, KAKENHI-PLANNED-19H05778, KAKENHI-PLANNED-24H02262, KAKENHI-PROJECT-24H00547, KAKENHI-PROJECT-23K06357
[Journal Article] Neurotransmitter recognition by human vesicular monoamine transporter 22024
- Author(s)
  Im Dohyun、Jormakka Mika、Juge Narinobu、Kishikawa Jun-ichi、Kato Takayuki、Sugita Yukihiko、Noda Takeshi、Uemura Tomoko、Shiimura Yuki、Miyaji Takaaki、Asada Hidetsugu、Iwata So
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 7661-7661
- DOI
  10.1038/s41467-024-51960-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24791, KAKENHI-PROJECT-23K06357, KAKENHI-PROJECT-24K09796, KAKENHI-PROJECT-24K21945, KAKENHI-PROJECT-22KK0099
[Journal Article] Structural insights into the agonists binding and receptor selectivity of human histamine H4 receptor2023
- Author(s)
  Im Dohyun、Kishikawa Jun-ichi、Shiimura Yuki、Hisano Hiromi、Ito Akane、Fujita-Fujiharu Yoko、Sugita Yukihiko、Noda Takeshi、Kato Takayuki、Asada Hidetsugu、Iwata So
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 6538-6538
- DOI
  10.1038/s41467-023-42260-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06357, KAKENHI-PROJECT-22K19431, KAKENHI-PLANNED-19H05777, KAKENHI-PROJECT-19H00923
[Journal Article] Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA2018
- Author(s)
  Suno Ryoji、Kimura Kanako Terakado、Nakane Takanori、Fujiwara Takaaki、Yamanaka Yasuaki、Im Dohyun、Rosenbaum Daniel M.、Iwata So、Shimamura Tatsuro、Kobayashi Takuya
- Journal Title
  
  Structure
  
  Volume: 26 Issue: 1 Pages: 7-19
- DOI
  10.1016/j.str.2017.11.005
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04338, KAKENHI-PROJECT-15K08268, KAKENHI-PROJECT-15K18376
[Journal Article] Ligand complex structures of L-amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813 and its conformational change2018
- Author(s)
  D. Im, D. Matsui, T. Arakawa, K. Isobe, Y. Asano, and S. Fushinobu
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8(3) Issue: 3 Pages: 314-324
- DOI
  10.1002/2211-5463.12387
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06169, KAKENHI-PROJECT-15K18376
[Presentation] 小胞型モノアミントランスポーター2 (VMAT2) の分子基盤研究2024
- Author(s)
  林到炫
- Organizer
  生体エネルギー研究会
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] Molecular Basis of GPCR Ligand Binding Revealed by Cryo-EM Structural Analysis2024
- Author(s)
  Dohyun Im
- Organizer
  APPW2025
- Invited
- Data Source
  KAKENHI-PROJECT-23K06357
[Presentation] Understanding the Structure and Receptor Selectivity of Histamine H4 Receptor2024
- Author(s)
  Dohyun Im
- Organizer
  IUPAB2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06357
[Presentation] Molecular Basis of GPCR Ligand Binding Revealed by Cryo-EM Structural Analysis2024
- Author(s)
  林到炫
- Organizer
  APPW2025
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] 小胞型モノアミントランスポーター2 (VMAT2) の分子基盤研究2024
- Author(s)
  林到炫
- Organizer
  日本生体エネルギー研究会第50回討論会
- Data Source
  KAKENHI-PROJECT-23K06357
[Presentation] 小胞型モノアミントランスポーター2 (VMAT2) 輸送機構解明2024
- Author(s)
  林到炫
- Organizer
  第24回千葉位大学MPRCセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K06357
[Presentation] 合理的な医薬品設計を目指したGPCR構造基盤研究2024
- Author(s)
  林到炫
- Organizer
  第216回久留米大学分子生命研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] 合理的な医薬品設計を目指したGPCR構造基盤研究2024
- Author(s)
  林到炫
- Organizer
  第216回久留米大学分子生命研セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K06357
[Presentation] クライオ電子顕微鏡単粒子解析による小胞型モノアミントランスポーター2 (VMAT2) 輸送機構解明2024
- Author(s)
  林到炫
- Organizer
  第24回千葉大学MPRCセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] Understanding the Structure and Receptor Selectivity of Histamine H4 Receptor2024
- Author(s)
  林到炫
- Organizer
  IUPAB2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0099
[Presentation] Frontiers in the Structural Biology of GPCRs2023
- Author(s)
  林到炫
- Organizer
  第57回日本味と勾学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06357
[Presentation] 新規抗ヒスタミン薬の分子設計を目指したヒスタミンH4受容体の構造基盤2023
- Author(s)
  林到炫
- Organizer
  第23回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-23K06357
[Presentation] Structural insights into antipsychotics binding modes in dopamine D2-class receptors2018
- Author(s)
  Dohyun Im, Yasuaki Yamanaka, Takaaki Fujiwara, Takanori Nakane, Tomoko Uemura, Chihiro Mori, Kanako Kimura, Eriko Nango, Kunio Hirata, Keitaro Yamashita, So Iwata and Tatsuro Shimamura
- Organizer
  Keystone Symposia: GPCR Structure and Function - Taking GPCR Drug Development and Discovery to the Next Level (Santa Fe, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18376
[Presentation] A first novel GPCR structure determined at SACLA2017
- Author(s)
  Dohyun Im, Tatsuro Shimamura, So Iwata
- Organizer
  2017 International Symposium on Frontiers in structural biology for Drug Development (Pohang, Korea)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18376

1. 浅田秀基 (20399041)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 椎村祐樹 (40551297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 堤尚孝 (70963495)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 堂浦智裕 (00745226)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 足立誠 (30335244)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 安田賢司 (40792081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 岩田想 (60452330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. INOUE Keiichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SHIMAMURA Tatsuro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. YAMANAKA Yasuaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 瀬川勝盛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 野村紀通

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 寿野良二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 神取秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 藤原孝彰

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 宮地孝明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 浅野泰久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 松井大亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Im Dohyun Ｉｍ Ｄｏｈｙｕｎ

林 到ヒョン イム ドヒョン

Research Projects

Research Products

Co-Researchers

ドパミン受容体におけるバイアスシグナルの構造基盤解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

プロテアーゼ活性化受容体の構造に基づく合理的新規抗凝固薬の探索

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膜蛋白質のクライオ電子顕微鏡システマティック解析を可能にするアプローチ

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new mechanism of drug selectivity for dopamine receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

グレリン受容体のシグナル伝達選択機構の構造基盤

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural Study of Human Dopamine D2 ReceptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 医学のあゆみ-統合失調症の未来 ─研究と治療2023

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Time-resolved small-angle X-ray scattering system development for the biological macromolecules at SACLA: A pilot study2025

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] The structure and function of the ghrelin receptor coding for drug actions2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovering key activation hotspots in the M2 muscarinic receptor2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dual 5-HT<sub>2A</sub> and 5-HT<sub>2C</sub> Receptor Inverse Agonist That Affords In Vivo Antipsychotic Efficacy with Minimal hERG Inhibition for the Treatment of Dementia-Related Psychosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Membrane structure-responsive lipid scrambling by TMEM63B to control plasma membrane lipid distribution2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structural basis for hepatitis B virus restriction by a viral receptor homologue2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A2A receptor2024

Author(s)

Im Dohyun ＩｍＤｏｈｙｕｎ

林到ヒョンイムドヒョン

[Presentation] クライオ電子顕微鏡単粒子解析による小胞型モノアミントランスポーター2 (VMAT2) 輸送機構解明2024