NOBUMICHI Hozumi 穂積信道

Researcher Number	60051744
Other IDs
Affiliation (based on the past Project Information) *help	2000 – 2007: 東京理科大学, 生命科学研究所, 教授 2001 – 2002: 東京理科大学, 生命科学研究所・生命工学技術部門, 教授 1999: 東京理科大学, 生命科学研究所・生命科学技術部門, 教授 1998: 東京理科大学, 生命科学研究所・生命工学技術部門, 教授 1997: 東京理科大学, 生命科学研究所・生命工学技術研究部門, 教授
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Periodontal dentistry / Laboratory animal science / 内科学一般 Except Principal Investigator Human pathology / Human pathology / Urology / Orthopaedic surgery
Keywords	Principal Investigator NOD-SCIDマウス / Runx2 / Notch1 / 転写因子 / 間葉系幹細胞 / DAPT / 骨形成 / 軟骨形成 / ATDC5 / SST-REX method … More / Notch / transcription factors / IL-7 rpepntnra / bone regeneration / chondrogenesis / ORtponalein / LBMC / コラーゲン遺伝子 / RUNX2 / IL-7Ra / 骨再生 / オステオカルシン / Ossification / Chondrogenesis / Limb bud micromass culture / 骨芽細胞 / 軟骨基質 / Conditional deletion mutantマウス / 遺伝子発現 / 内軟骨性骨化 / 細胞凝集 / マウス肢芽 / Limb Bud Micromass Culture / Limb bud micro-mass culture / CD4+ T cells / human immune response / periodontitis / Actinohacilllis actinnmycetemcomitans / NOD-SCID mouse / IgG / Limiting Dilution Assay / Actinobacillus actionomycetemcomitans / SCODマウス / NOD / CD4^+T細胞 / ヒトリンパ球 / Actinobacillus actinomycetemcomitans / プラーク(細菌塊) / 腎皮膜下移植 / ヒト肝細胞 / HCV / 免疫組織化学染色 / ヒト肝組織 / RT-PCR / ヒトC型肝炎ウイルス / ヒトイト動物モデル / NOD-SCID マウス / ヒト化動物モデル / C型肝炎ウイルス / インスリン / トランスジェニックマウス / 自己免疫寛容 / 自己免疫 / ヒト免疫細胞 / エイズ / SCIDマウス … More Except Principal Investigator NOD / leukemia / angiogenesis / 血管内皮細胞 / レトロウイルスベクター / SCIDマウス / ヒト腫瘍血管新生 / VEGF / bcl-2 / 血管新生 / ATDC5 / Notch / 腫瘍血管 / Cell・Tissue / Angiogenesis / Pathology / Cacer / 免疫学 / 癌 / 細胞・組織 / 白血病 / 病理学 / がん / tek tyrosine kinase / angiopoietin / SCID mice / human cancer / 骨髄ストローマ細胞 / アンギオポエチン / 腫瘍血管新生 / Angiopoietin受容体Tek / インテグリン / レトロウイルス / NFkappaB / bone metastases / prostate cancer / ヒト腫瘍血管新 / 遺伝子治療 / NFκB / 骨転移 / 前立腺癌 / Adenovirus vector / MC3T3-EI / Human mesenchymal stem cells / HuBone-NOD-SCID mice / 運動療法 / 力学負荷 / POEM / 軟骨細胞 / 内軟骨性骨化 / 骨芽細胞 / Signal Sequence Trap / アデノウイルスベクター / MC3T3-E1 / ヒト間葉系幹細胞 / HuBone-NOD-SCIDマウス / cell transplantation / bone marrow stroma / heart muscle / hetatitis / tumor angiogenesis / Osteoporisis / Regeneration / 骨粗しょう症 / 細胞移植 / 骨髄間質 / 心筋 / 肝炎 / 骨粗鬆症 / 再生 Less

Studies on molecular mechanisms involved in chondrogenesis by transcription factorsPrincipal Investigator
- Principal Investigator
  
  HOZINUI Nobumichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo University of Science
Establishment of in vivo model for angiogenesis in hematological malignancy and development of anti-angiogenic therapy.
- Principal Investigator
  
  YAMADA Taketo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  KEIO UNIVERSITY
Studies on molecular mechanisms involved in differentiation of chondrocyte/osteoblast by NotchPrincipal Investigator
- Principal Investigator
  
  HOZUMI Nobumichi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Tokyo University of Science
ヒト臓器を移植された新しいヒト疾患動物モデルの確立Principal Investigator
- Principal Investigator
  
  穂積信道
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Laboratory animal science
- Research Institution
  Tokyo University of Science
Development of bone regeneration therapy for osteoporosis using humanized mice
- Principal Investigator
  
  TOYAMA Yoshiaki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Keio University
Establishment of a novel mouse model for studying prostate cancer metastasis to human bone and new therapeutic strategies.
- Principal Investigator
  
  MURAI Masaru
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Urology
- Research Institution
  KEIO UNIVERSITY
Model for human tumor sngiogenesis using NOD/SCID mice
- Principal Investigator
  
  YAMADA Taketo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  Keio University
Development of novel humanized-mice and application to regenerative medicine
- Principal Investigator
  
  HATA Jun-ichi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Human pathology
- Research Institution
  National Research Institute for Child Health and Development
  Keio University
Analysis of human immune response in periodontitis using a noble mouse modelPrincipal Investigator
- Principal Investigator
  
  NOBUMICHI Hozumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontal dentistry
- Research Institution
  Tokyo University of Science
HCV感染のための新しい動物モデルの開発Principal Investigator
- Principal Investigator
  
  穂積信道
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  内科学一般
- Research Institution
  Tokyo University of Science
HIV感染の新しい動物モデルの確立Principal Investigator
- Principal Investigator
  
  穂積信道
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science
T細胞受容体によるMHCクラスII/抗原ペプチドの認識機構Principal Investigator
- Principal Investigator
  
  穂積信道
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo University of Science

All 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book

[Book] いのちのキーワード免疫2006
- Author(s)
  穂積信道
- Total Pages
  163
- Publisher
  オーム社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390490
[Book] Recent development in Immunology(分担執筆)2004
- Author(s)
  Hozumi, N., Kohyama, M.
- Total Pages
  371
- Publisher
  Research Signpost
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390557
[Journal Article] Two of four alternatively Spliced isoforms of RUNX2 control OSTEOCALCIN gene expression in Human osteoblast cells2008
- Author(s)
  Makita, N., Suzuki, M., Asami, S., Takahata, R., Kohzaki, D., Kobayashi, S., Hakamazuka, T., Hozumi, N
- Journal Title
  
  Gene 413
  
  Pages: 8-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390490
[Journal Article] Site specific DNA methylatlion by a complex of PU.1 and Dnmt3a/b2006
- Author(s)
  Suzuki, M., Yamada, F., Kihara-Negishi, F., Sakurai, T., Hara, E., Tenen, D.G., Hozumi, N., Oikawa, T.
- Journal Title
  
  Oncogene 25
  
  Pages: 2477-2488
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390557
[Journal Article] Involvement of Notch signaling in initiation of prechondrogenic condensation and formation of nodules in limb bud micromass cultures2006
- Author(s)
  Fujimaki, R., Toyama, Y., Hozumi, N., Tezuka, K.
- Journal Title
  
  J.Bone Miner.Metab. 24
  
  Pages: 191-198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390557
[Journal Article] Use of the SST-REX method for the Identificationof genes expressed at the condensation stage of chondrogenic Cell line ATDC2006
- Author(s)
  Noguchi, A., Watanabe, N., Fujimaki, R., Kitamura, T., Hayashizaki, Y., Miyaki, S., Tezuka, K., Hozumin N
- Journal Title
  
  J. Bone Miner. Metab 24
  
  Pages: 153-157
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390490
[Journal Article] Site specific DNA methylation By a complex of PU.1 and Dnint3a/b2006
- Author(s)
  Suzuki, M., Yamada, F., Klhara-Negishi, F., Sakurai, T., Hara, E., Tene, D. G., Hozumi, N., Oikawa, T
- Journal Title
  
  Oncogen 25
  
  Pages: 2477-2488
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390490
[Journal Article] use of the SST-REX method for the identification of genes expressed at the condensation, stage of chondrogenic cell line ATDC52006
- Author(s)
  Noguchi, A., Watanabe, N., Fujimaki, R., Kitamura, T., Hayashizaki, Y., Miyaki, S., Tezuka, K., Hozumi, N.
- Journal Title
  
  J.Bone Miner.Metab. 24
  
  Pages: 153-157
- NAID
  10018194449
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390557
[Journal Article] Involvement of Notch signaling in initiation of prechondrogenic condensation and Formation of nodules in limb bud micromass cultures2006
- Author(s)
  Fujimaki, R., Toyama, Y., HOzumi, N., Tezuka, K
- Journal Title
  
  J. Bone Miner. Meta 24
  
  Pages: 191-198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390490
[Journal Article] Expression of Cre recombinase in the mouse developing chondrocytes driven by the mouse a2(XI) collagen promoter.2005
- Author(s)
  Fujimak, R., Hayashi, K., Watanabe, N., Yamada, T., Toyama, Y., Tezuka, K., Hozumi, N.
- Journal Title
  
  J.Bone Miner.Metab. 23
  
  Pages: 270-273
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390557
[Journal Article] Catechin, a green tea component, rapidly induces apoptosis of myeloid leukem cells via modulation of reactive oxygen species (ROS) production in vitro an inhibits tumor growth in vivo.2005
- Author(s)
  Nakazato T, Ito K, Miyakawa Y, Kinjo K, Yamada T, Hozumi N, Ikeda Y, Kizaki M
- Journal Title
  
  Hematologica 90(3)
  
  Pages: 317-325
- Data Source
  KAKENHI-PROJECT-17590318
[Journal Article] Expression of Cre recombinase in the mouse developing chondrocytes driven by th mouse a2(XI) collagen promoter.2005
- Author(s)
  Fujimaki R, Hayashi K, Watanabe N, Yamada T, Toyama Y, Tezuka K, Hozumi
- Journal Title
  
  J Bone and Mineral Metabolism 23(3)
  
  Pages: 270-273
- Data Source
  KAKENHI-PROJECT-17590318
[Journal Article] 1'-acetoxychavicol acetate is a novel muclear factor-kB inhibitor with significant activity against multiple myeloma in vitro and in vivo.2005
- Author(s)
  Ito K, Nakazato T, Xian MJ, Yamada T, Hozumi N, Murakami A, Ohigashi H, Ikeda Y, Kizaki M
- Journal Title
  
  Cancer Research 65(10)
  
  Pages: 4417-4424
- Data Source
  KAKENHI-PROJECT-17590318
[Journal Article] Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen.2004
- Author(s)
  Kohyama, M., Sugahara, D., Sugiyama, S., Yagita, H., Okumura, K., Hozumi, N.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 101
  
  Pages: 4192-4197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390557
[Journal Article] Suppression of differentiation and proliferation of early chondrogenic cells by Notch.2003
- Author(s)
  Watanabe, N., Tezuka, Y., Matsuno, K., Miyatani, S., Morimura, N., Yasuda, M., Fujimaki, R., Kuroda, K., Hiraki, Y., Hozumi, N., Tezuka, K.
- Journal Title
  
  J.Bone Miner.Metab. 21
  
  Pages: 344-352
- NAID
  10014445248
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390557
[Journal Article] Regulatory T cells in mice expressing exogenous self-antigens
- Author(s)
  Hozumi, N., et. al.
- Journal Title
  
  Recent Development in Immunology (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390490
[Presentation] マウス肢芽のmicromass cultureにおける軟骨細胞分化とNotchとの関与2007
- Author(s)
  小林翔、鈴木光浩、槙田直之、穂積信道
- Organizer
  第30回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-18390490
[Presentation] Regulatory mechanisms of B cell Proliferation by CD722007
- Author(s)
  Hozumi, N., Baba, T., Fusaki, N
- Organizer
  The 13th International Congress of Immunology
- Place of Presentation
  Rio de HJaneiro
- Year and Date
  2007-08-23
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390490
[Presentation] Regulatory mechanisms of B cell proliferation by CD722007
- Author(s)
  Hozumi, N., et. al.
- Organizer
  The 13th International Congress of Imlnunology
- Place of Presentation
  Rio de Janeiro,Brazil
- Year and Date
  2007-08-23
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390490
[Presentation] Enhanced calcification and osteoblastic differentiation of human bone marrow stromal cells by Notch.2002
- Author(s)
  Hozumi N, Yasuda M, Morimura N, Watanabe N, Fujimaki R, Hata J, Yamada T, Tezuka K.
- Organizer
  The 5th Tissue Engineering Society International
- Place of Presentation
  神戸
- Year and Date
  2002-12-10
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12357002
[Presentation] Enhanced calcification and osteoblastic differentiation of human bone marrow stromal cells by Notch2002
- Author(s)
  Hozumi N, Yasuda M, Morimura N, Watanabe N, Fujimaki R, Hata J, Yamada T, Tezuka K.
- Organizer
  The 5th Tissue Engineering Society International
- Place of Presentation
  Kobe, Japan
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12357002

1. YAMADA Taketo (60230463)

# of Collaborated Projects: 6 results

# of Collaborated Products: 5 results
2. KENICHI Tezuka (50236973)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 今田美恵 (50291703)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. HATA Jun-ichi (90051614)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SUZUKI Mitsuhiro (00321662)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 香山雅子 (80318229)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 渡辺守 (10175127)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. UMWZAWA Akhiro (70213486)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YOSHIYUKI Hakeda (90164772)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TOYAMA Yoshiaki (40129549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MURAI Masaru (90101956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. OYA Mototsugu (00213885)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. NAKASHIMA Jun (10167546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MORIMURA Naoko (00349044)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. SHIBUI Akiko (50313846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉村泰典 (10129736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 中野直子 (90222166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 房木ノエミ (40278635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 堀内圭輔 (30327564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岩本潤 (40245527)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 杜ぶん林 (90348798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. FUJIMOTO Jun-ichiroh

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. KIYOKAWA Nobutaka

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SAKURADA Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. OHTA Hideo

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. ITO Fumio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 清河信隆

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NOBUMICHI Hozumi 穂積 信道

Research Projects

Research Products

Co-Researchers

Studies on molecular mechanisms involved in chondrogenesis by transcription factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of in vivo model for angiogenesis in hematological malignancy and development of anti-angiogenic therapy.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on molecular mechanisms involved in differentiation of chondrocyte/osteoblast by NotchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒト臓器を移植された新しいヒト疾患動物モデルの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of bone regeneration therapy for osteoporosis using humanized mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a novel mouse model for studying prostate cancer metastasis to human bone and new therapeutic strategies.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Model for human tumor sngiogenesis using NOD/SCID mice

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of novel humanized-mice and application to regenerative medicine

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of human immune response in periodontitis using a noble mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HCV感染のための新しい動物モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HIV感染の新しい動物モデルの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

T細胞受容体によるMHCクラスII/抗原ペプチドの認識機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

[Book] いのちのキーワード免疫2006

Author(s)

Total Pages

Publisher

Description

Data Source

NOBUMICHI Hozumi 穂積信道